CN108524847A - A kind of externally applied drug and preparation method thereof for treating dermatitis - Google Patents

A kind of externally applied drug and preparation method thereof for treating dermatitis Download PDF

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Publication number
CN108524847A
CN108524847A CN201810746035.8A CN201810746035A CN108524847A CN 108524847 A CN108524847 A CN 108524847A CN 201810746035 A CN201810746035 A CN 201810746035A CN 108524847 A CN108524847 A CN 108524847A
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parts
mixture
weight
dermatitis
externally applied
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万家林
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Hefei Fengruilong Biological Technology Co Ltd
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Hefei Fengruilong Biological Technology Co Ltd
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
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    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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Abstract

The invention discloses a kind of externally applied drugs and preparation method thereof for treating dermatitis, with rhodiola root, realgar, the root bark of shaggy-fruited dittany, honey, Long Stephania Herb, peppermint, borneol, light-coloured vinegar, corn stigma, the tuber of stemona, oriental wormwood, the fruit of summer cypress, white wine, sulphur, asparagus juice, pericarpium zanthoxyli, Oleum Verniciae fordii, mung bean flour, pearl powder, land plaster, uva ursi, potato, bamboo salt is that raw material disinfection make up remover ointment obtained is without any side effects, treatment time is short, difficulty in relapse after healing, over the course for the treatment of, have the function of repairing epidermis and protects epidermal tissue, use the ointment of the present invention, it is not required to plus matches any medicine for oral administration, for erythema caused by treatment dermatitis, swelling, papule, blister, bleb, the symptoms such as fever have quick, cure rate is high, it has no toxic side effect, safe ready, the advantages that curative effect is lasting.

Description

A kind of externally applied drug and preparation method thereof for treating dermatitis
Technical field
The present invention relates to dermatitis field, especially a kind of externally applied drug and preparation method thereof for treating dermatitis.
Background technology
Nearly more than ten years, dermatitis patients start in situation is steeply risen, although dermatitis patients ten are not distinguished also the reason of sharp increase Chu, but substantially it is considered that 3 reasons.First is the variation of dietetic life, that is, from traditional centered on vegetables Eating habit develops into of today with the increase of the dairy products intake such as meat, butter, cheese, therefore constitution also becomes Change.Second is the variation of living environment.That is, natural timber, soil, paper, the house of straw mattress construction are various to today in the past Synthesize the variation of the construction materials such as building materials, chemical synthesis paste, chemical cushion, the various chemical substances for including in these building materials It is discharged into living environment and influences constitution and change.In addition, from the fiber system with natural materials such as pervious wool or cottons The variation of clothes is made of various chemical fibres till now at clothes causes the stimulation to skin to increase, from soap clothes to Changed with the laundry mode of synthesis of detergent agent or dry-cleaning laundry and using for agent etc. is sent out in shampoo, hair conditioner and sizing. In terms of third is work, the continuous continuous improvement accelerated with job requirement of rhythm of life causes all to bear from child to adult Excessive pressure, and make hypoimmunity.
In order to be prevented dermatitis or be treated, various therapeutic schemes are had studied, but be nearly all to inhibit suiting the medicine to the illness for symptom The countermeasure of therapy, especially well known as the heteropathy of doctor trained in Western medicine such as antihistaminic, antiallergy medicament, anti-inflammatory agent Agent, steroid dose etc., but be not ideal drug no matter from the point of view of pharmacological effect or side effect.
Invention content
In view of this, the object of the present invention is to provide a kind of externally applied drug and preparation method thereof for treating dermatitis, for treatment The symptoms such as erythema caused by dermatitis, swelling, papule, blister, bleb, fever are with quick, cure rate is high, has no toxic side effect.
To achieve the goals above, the present invention provides the following technical solutions：
A kind of externally applied drug for treating dermatitis, includes the raw material of following parts by weight：
Preferably, include the raw material of following parts by weight：
Preferably, further include vaseline, the parts by weight of the vaseline are 200~300 parts.
Preferably, the number of degrees of the white wine are 40~60 °.
The present invention also provides a kind of above-mentioned preparation methods of externally applied drug that treating dermatitis, include the following steps：
A) by rhodiola root, the root bark of shaggy-fruited dittany, Long Stephania Herb, peppermint, corn stigma, the tuber of stemona, oriental wormwood, the fruit of summer cypress, pericarpium zanthoxyli, uva ursi, soil Beans dry 3~4h at 50~60 DEG C, and 100~200 mesh screens are crushed after drying, are mixed to get the first mixture, spare；
B) realgar, borneol, sulphur, mung bean flour, pearl powder, land plaster, bamboo salt be crushed into 200~300 mesh screens, obtained Second mixture, it is spare；
C) by step a) obtain the first mixture be added in white wine and the mixed liquor of light-coloured vinegar in impregnate 20~30h, obtain Second mixture；
D) the second mixture, honey, Oleum Verniciae fordii is added in the first mixture obtained to step c), is uniformly mixing to obtain Three mixtures；
E) vaseline is added in the third mixture obtained to step d), is uniformly mixed to obtain the final product.
The present invention provides a kind of externally applied drugs and preparation method thereof for treating dermatitis, with rhodiola root, realgar, the root bark of shaggy-fruited dittany, bee Honey, Long Stephania Herb, peppermint, borneol, light-coloured vinegar, corn stigma, the tuber of stemona, oriental wormwood, the fruit of summer cypress, white wine, sulphur, asparagus juice, pericarpium zanthoxyli, paulownia seed Oil, mung bean flour, pearl powder, land plaster, uva ursi, potato, bamboo salt are raw material disinfection make up remover ointment obtained without any secondary work With treatment time is short, difficulty in relapse after healing, over the course for the treatment of, has the function of repairing epidermis and protects epidermal tissue, use The ointment of the present invention is not required to plus matches any medicine for oral administration, for erythema, swelling, papule, blister, bleb, hair caused by treatment dermatitis The symptoms such as heat have many advantages, such as that quick, cure rate is high, have no toxic side effect, safe ready, curative effect are lasting.
Specific implementation mode
A kind of externally applied drug for treating dermatitis provided by the invention, includes the raw material of following parts by weight：
Above-mentioned technical proposal, with rhodiola root, realgar, the root bark of shaggy-fruited dittany, honey, Long Stephania Herb, peppermint, borneol, light-coloured vinegar, corn stigma, The tuber of stemona, oriental wormwood, the fruit of summer cypress, white wine, sulphur, asparagus juice, pericarpium zanthoxyli, Oleum Verniciae fordii, mung bean flour, pearl powder, land plaster, uva ursi, soil Beans, bamboo salt are that raw material disinfection make up remover ointment obtained is without any side effects, and treatment time is short, difficulty in relapse after healing, is treating In the process, have the function of repairing epidermis and protect epidermal tissue, using the ointment of the present invention, be not required to plus match any medicine for oral administration, For the symptoms such as erythema, swelling, papule, blister, bleb, fever caused by treatment dermatitis with quick, cure rate is high, nontoxic The advantages that side effect, safe ready, lasting curative effect.
Rhodiola root has the function of qi and activate blood circulation, antiasthmatic-antitussive, anti-aging.In the present invention, the parts by weight of rhodiola root It is 20~40 parts；In an embodiment of the present invention, the parts by weight of rhodiola root are 25~35 parts；The parts by weight of rhodiola root are 28 ~32 parts.
Realgar has effects that the desinsection that detoxifies.In the present invention, the parts by weight of realgar are 5~10 parts；The present invention's In embodiment, the parts by weight of realgar are 6~9 parts；The parts by weight of realgar are 7~8 parts.
The root bark of shaggy-fruited dittany has the function of clearing heat and detoxicating.In the present invention, the parts by weight of the root bark of shaggy-fruited dittany are 10~20 parts；In this hair In bright embodiment, the parts by weight of the root bark of shaggy-fruited dittany are 12~18 parts；The parts by weight of the root bark of shaggy-fruited dittany are 14~16 parts.
Honey plays the role of skin care.In the present invention, the parts by weight of honey are 10~20 parts；The present invention's In embodiment, the parts by weight of honey are 12~18 parts；The parts by weight of honey are 14~16 parts.
Long Stephania Herb has the function of detoxification detumescence.In the present invention, the parts by weight of Long Stephania Herb are 7~15 parts；In this hair In bright embodiment, the parts by weight of Long Stephania Herb are 9~13 parts；The parts by weight of Long Stephania Herb are 10~12 parts.
Peppermint plays refrigerant antipruritic effect.In the present invention, the parts by weight of peppermint are 8~16 parts；The present invention's In embodiment, the parts by weight of peppermint are 10~14 parts；The parts by weight of peppermint are 11~13 parts.
Borneol has effects that detumescence, promoting blood circulation, analgesic.In the present invention, the parts by weight of borneol are 4~9 parts；In this hair In bright embodiment, the parts by weight of borneol are 5~8 parts；The parts by weight of borneol are 6~7 parts.
Light-coloured vinegar has the function of sterilization.In the present invention, the parts by weight of light-coloured vinegar are 2~5 parts；In the embodiment of the present invention In, the parts by weight of light-coloured vinegar are 2.5~4.5 parts；The parts by weight of light-coloured vinegar are 3~4 parts.
Corn stigma is used to improve antiallergy effect for the treatment of dermatitis externally applied drug.In the present invention, the parts by weight of corn stigma It is 6~10 parts；In an embodiment of the present invention, the parts by weight of corn stigma are 7~9 parts；The parts by weight of corn stigma be 7.5~ 8.5 part.
The tuber of stemona has the function of antipruritic.In the present invention, the parts by weight of the tuber of stemona are 3~7 parts；In the embodiment of the present invention In, the parts by weight of the tuber of stemona are 4~6 parts；The parts by weight of the tuber of stemona are 4.5~5.5 parts.
Oriental wormwood has the function of antipyretic, anti-inflammatory.In the present invention, the parts by weight of oriental wormwood are 6~12 parts；The present invention's In embodiment, the parts by weight of oriental wormwood are 7~11 parts；The parts by weight of oriental wormwood are 8~10 parts.
The fruit of summer cypress has the effect of clearing heat and promoting diuresis, dispelling wind and arresting itching.In the present invention, the parts by weight of the fruit of summer cypress are 15~30 Part；In an embodiment of the present invention, the parts by weight of the fruit of summer cypress are 18~27 parts；The parts by weight of the fruit of summer cypress are 20~25 parts.
White wine can be by rhodiola root, the root bark of shaggy-fruited dittany, Long Stephania Herb, peppermint, corn stigma, the tuber of stemona, oriental wormwood, the fruit of summer cypress, pericarpium zanthoxyli, black bearberry Active constituent in leaf, potato extracts.In an embodiment of the present invention, the number of degrees of white wine are 40~60 °.
In the present invention, the parts by weight of white wine are 80~100 parts；In an embodiment of the present invention, the parts by weight of white wine Number is 85~95 parts.
Sulphur plays the role of disinfection.In the present invention, the parts by weight of sulphur are 2~4 parts；The present invention's In embodiment, the parts by weight of sulphur are 2.5~3.5 parts；The parts by weight of sulphur are 2.8~3.2 parts.
Asparagus juice plays the role of eliminating mark.In the present invention, the parts by weight of asparagus juice are 7~15 parts；In this hair In bright embodiment, the parts by weight of asparagus juice are 9~13 parts；The parts by weight of asparagus juice are 10~12 parts.
Pericarpium zanthoxyli has the function of relieving pain desinsection, removing toxic substances qi-regulating.In the present invention, the parts by weight of pericarpium zanthoxyli are 3~5 parts； In the embodiment of the present invention, the parts by weight of pericarpium zanthoxyli are 3.5~4.5 parts；The parts by weight of pericarpium zanthoxyli are 3.8~4.2 parts.
Oleum Verniciae fordii is used to improve the osmosis for the treatment of dermatitis externally applied drug.In the present invention, the parts by weight of Oleum Verniciae fordii are 6 ~10 parts；In an embodiment of the present invention, the parts by weight of Oleum Verniciae fordii are 7~9 parts；The parts by weight of Oleum Verniciae fordii are 7.5~8.5 Part.
Mung bean flour plays cleaning skin, and miscellaneous bacteria is avoided to infect.In the present invention, the parts by weight of mung bean flour are 8~16 parts； In an embodiment of the present invention, the parts by weight of mung bean flour are 10~14 parts；The parts by weight of mung bean flour are 11~13 parts.
Pearl powder plays the role of moisturizing.In the present invention, the parts by weight of pearl powder are 4~8 parts；In the present invention Embodiment in, the parts by weight of pearl powder are 5~7 parts；The parts by weight of pearl powder are 5.5~6.5 parts.
Land plaster plays expelling pathogenic factors from muscles for clearing heat, and relieving restlessness quenches the thirst, clearing heat and detoxicating effect.In the present invention, the weight of land plaster Number is 3~6 parts；In an embodiment of the present invention, the parts by weight of land plaster are 4~5 parts.
Uva ursi, which can play, prevents melanin production, captures skin surface free radical, decomposes skin surface fossil pigments, The effect of mark can effectively be desalinated.In the present invention, the parts by weight of uva ursi are 5~8 parts；In an embodiment of the present invention, The parts by weight of uva ursi are 6~7 parts.
Potato plays the role of detoxicating, relieving inflammation, activating blood circulation and reducing swelling.In the present invention, the parts by weight of potato are 6~15 parts； In the embodiment of the present invention, the parts by weight of potato are 8~13 parts；The parts by weight of potato are 10~11 parts.
Bamboo salt has effects that toxin expelling.In the present invention, the parts by weight of bamboo salt are 5~8 parts；In the embodiment of the present invention In, the parts by weight of bamboo salt are 6~7 parts.
The present invention also provides a kind of above-mentioned preparation methods of externally applied drug that treating dermatitis, include the following steps：
A) by rhodiola root, the root bark of shaggy-fruited dittany, Long Stephania Herb, peppermint, corn stigma, the tuber of stemona, oriental wormwood, the fruit of summer cypress, pericarpium zanthoxyli, uva ursi, soil Beans dry 3~4h at 50~60 DEG C, and 100~200 mesh screens are crushed after drying, are mixed to get the first mixture, spare；
B) realgar, borneol, sulphur, mung bean flour, pearl powder, land plaster, bamboo salt be crushed into 200~300 mesh screens, obtained Second mixture, it is spare；
C) by step a) obtain the first mixture be added in white wine and the mixed liquor of light-coloured vinegar in impregnate 20~30h, obtain Second mixture；
D) the second mixture, honey, Oleum Verniciae fordii is added in the first mixture obtained to step c), is uniformly mixing to obtain Three mixtures；
E) vaseline is added in the third mixture obtained to step d), is uniformly mixed to obtain the final product.
Wherein, rhodiola root, realgar, the root bark of shaggy-fruited dittany, honey, Long Stephania Herb, peppermint, borneol, light-coloured vinegar, corn stigma, the tuber of stemona, oriental wormwood, The fruit of summer cypress, white wine, sulphur, asparagus juice, pericarpium zanthoxyli, Oleum Verniciae fordii, mung bean flour, pearl powder, land plaster, uva ursi, potato, bamboo salt are same Upper described, details are not described herein.
Above-mentioned technical proposal is simple, and formula is reasonable, and of low cost, significant in efficacy, nontoxic, without side-effects, technique simply may be used Row, externally applied drug obtained can directly act on the diseased region for the treatment of treatment dermatitis, and curative effect is apparent, and without any allergic reaction, Maintenance, moisturizing effect are good, skin-friendly health.
In order to further illustrate the present invention, with reference to embodiment to a kind of externally applied drug for treating dermatitis provided by the invention And preparation method thereof be described in detail, but they cannot be interpreted as limiting the scope of the present invention.
Embodiment 1
The externally applied drug for treating dermatitis, includes the raw material of following parts by weight：
35 parts of rhodiola roots, 6 portions of realgars, 12 parts of root bark of shaggy-fruited dittanys, 14 parts of honey, 9 parts of Long Stephania Herbs, 10 portions of peppermints, 6 parts of borneols, 2.5 Part light-coloured vinegar, 7.5 parts of corn stigmas, 4 parts of tubers of stemona, 7 portions of oriental wormwoods, 25 parts of fruit of summer cypress, 85 parts of white wine, 2.8 parts of sulphur, 10 portions of asparagus juices, 3.8 portions of pericarpium zanthoxylis, 6 parts of Oleum Verniciae fordiis, 16 parts of mung bean flours, 5.5 parts of pearl powders, 4 parts of land plasters, 6 parts of uva ursis, 11 portions of potatoes, 6 portions of bamboos Salt, 200 parts of vaseline.
The preparation method for treating the externally applied drug of dermatitis, includes the following steps：
A) by rhodiola root, the root bark of shaggy-fruited dittany, Long Stephania Herb, peppermint, corn stigma, the tuber of stemona, oriental wormwood, the fruit of summer cypress, pericarpium zanthoxyli, uva ursi, soil Beans dry 3h at 50 DEG C, and 150 mesh screens are crushed after drying, are mixed to get the first mixture, spare；
B) realgar, borneol, sulphur, mung bean flour, pearl powder, land plaster, bamboo salt be crushed into 2500 mesh screens, obtains second Mixture, it is spare；
C) step a) is obtained into the first mixture to be added to the mixed of the light-coloured vinegar for being 10% with purity in the white wine that the number of degrees are 60 ° It closes in liquid and impregnates 20h, obtain the second mixture；
D) the second mixture, honey, Oleum Verniciae fordii is added in the first mixture obtained to step c), is uniformly mixing to obtain Three mixtures；
E) vaseline is added in the third mixture obtained to step d), is uniformly mixed to obtain the final product.
Embodiment 2
The externally applied drug for treating dermatitis, includes the raw material of following parts by weight：
32 parts of rhodiola roots, 9 portions of realgars, 14 parts of root bark of shaggy-fruited dittanys, 16 parts of honey, 13 parts of Long Stephania Herbs, 14 portions of peppermints, 7 parts of borneols, 4.5 parts of light-coloured vinegars, 8.5 parts of corn stigmas, 6 parts of tubers of stemona, 8 portions of oriental wormwoods, 15 parts of fruit of summer cypress, 95 parts of white wine, 3.2 parts of sulphur, 12 portions of aloes Juice, 4.2 portions of pericarpium zanthoxylis, 10 parts of Oleum Verniciae fordiis, 8 parts of mung bean flours, 6.5 parts of pearl powders, 5 parts of land plasters, 7 parts of uva ursis, 10 parts of potatoes, 5 Part bamboo salt, 300 parts of vaseline.
The preparation method for treating the externally applied drug of dermatitis, includes the following steps：
A) by rhodiola root, the root bark of shaggy-fruited dittany, Long Stephania Herb, peppermint, corn stigma, the tuber of stemona, oriental wormwood, the fruit of summer cypress, pericarpium zanthoxyli, uva ursi, soil Beans dry 3h at 60 DEG C, and 20 mesh screens are crushed after drying, are mixed to get the first mixture, spare；
B) realgar, borneol, sulphur, mung bean flour, pearl powder, land plaster, bamboo salt be crushed into 300 mesh screens, obtains second Mixture, it is spare；
C) step a) is obtained into the first mixture to be added to the mixed of the light-coloured vinegar for being 10% with purity in the white wine that the number of degrees are 40 ° It closes in liquid and impregnates 30h, obtain the second mixture；
D) the second mixture, honey, Oleum Verniciae fordii is added in the first mixture obtained to step c), is uniformly mixing to obtain Three mixtures；
E) vaseline is added in the third mixture obtained to step d), is uniformly mixed to obtain the final product.
Embodiment 3
The externally applied drug for treating dermatitis, includes the raw material of following parts by weight：
20 parts of rhodiola roots, 7 portions of realgars, 16 parts of root bark of shaggy-fruited dittanys, 12 parts of honey, 7 parts of Long Stephania Herbs, 11 portions of peppermints, 5 parts of borneols, 3 parts Light-coloured vinegar, 7 parts of corn stigmas, 3 parts of tubers of stemona, 10 portions of oriental wormwoods, 18 parts of fruit of summer cypress, 80 parts of white wine, 2.5 parts of sulphur, 9 portions of asparagus juices, 3.5 parts Pericarpium zanthoxyli, 7 parts of Oleum Verniciae fordiis, 10 parts of mung bean flours, 5 parts of pearl powders, 3 parts of land plasters, 5 parts of uva ursis, 8 portions of potatoes, 7 parts of bamboo salts, 240 parts Vaseline.
The preparation method for treating the externally applied drug of dermatitis, includes the following steps：
A) by rhodiola root, the root bark of shaggy-fruited dittany, Long Stephania Herb, peppermint, corn stigma, the tuber of stemona, oriental wormwood, the fruit of summer cypress, pericarpium zanthoxyli, uva ursi, soil Beans dry 4h at 50 DEG C, and 100 mesh screens are crushed after drying, are mixed to get the first mixture, spare；
B) realgar, borneol, sulphur, mung bean flour, pearl powder, land plaster, bamboo salt be crushed into 200 mesh screens, obtains second Mixture, it is spare；
C) step a) is obtained into the first mixture to be added to the mixed of the light-coloured vinegar for being 10% with purity in the white wine that the number of degrees are 50 ° It closes in liquid and impregnates 25h, obtain the second mixture；
D) the second mixture, honey, Oleum Verniciae fordii is added in the first mixture obtained to step c), is uniformly mixing to obtain Three mixtures；
E) vaseline is added in the third mixture obtained to step d), is uniformly mixed to obtain the final product.
Embodiment 4
The externally applied drug for treating dermatitis, includes the raw material of following parts by weight：
40 parts of rhodiola roots, 8 portions of realgars, 10 parts of root bark of shaggy-fruited dittanys, 18 parts of honey, 15 parts of Long Stephania Herbs, 13 portions of peppermints, 8 parts of borneols, 4 Part light-coloured vinegar, 9 parts of corn stigmas, 7 parts of tubers of stemona, 11 portions of oriental wormwoods, 30 parts of fruit of summer cypress, 100 parts of white wine, 3.5 parts of sulphur, 13 portions of asparagus juices, 4.5 portions of pericarpium zanthoxylis, 9 parts of Oleum Verniciae fordiis, 14 parts of mung bean flours, 7 parts of pearl powders, 6 parts of land plasters, 8 parts of uva ursis, 13 portions of potatoes, 8 portions of bamboos Salt, 280 parts of vaseline.
The preparation method for treating the externally applied drug of dermatitis, includes the following steps：
A) by rhodiola root, the root bark of shaggy-fruited dittany, Long Stephania Herb, peppermint, corn stigma, the tuber of stemona, oriental wormwood, the fruit of summer cypress, pericarpium zanthoxyli, uva ursi, soil Beans dry 3.5h at 55 DEG C, and 150 mesh screens are crushed after drying, are mixed to get the first mixture, spare；
B) realgar, borneol, sulphur, mung bean flour, pearl powder, land plaster, bamboo salt be crushed into 250 mesh screens, obtains second Mixture, it is spare；
C) step a) is obtained into the first mixture to be added to the mixed of the light-coloured vinegar for being 10% with purity in the white wine that the number of degrees are 40 ° It closes in liquid and impregnates 25h, obtain the second mixture；
D) the second mixture, honey, Oleum Verniciae fordii is added in the first mixture obtained to step c), is uniformly mixing to obtain Three mixtures；
E) vaseline is added in the third mixture obtained to step d), is uniformly mixed to obtain the final product.
Embodiment 5
The externally applied drug for treating dermatitis, includes the raw material of following parts by weight：
25 parts of rhodiola roots, 5 portions of realgars, 20 parts of root bark of shaggy-fruited dittanys, 10 parts of honey, 10 parts of Long Stephania Herbs, 8 portions of peppermints, 4 parts of borneols, 2 parts Light-coloured vinegar, 6 parts of corn stigmas, 4.5 parts of tubers of stemona, 12 portions of oriental wormwoods, 25 parts of fruit of summer cypress, 90 parts of white wine, 2 parts of sulphur, 7 portions of asparagus juices, 3 parts of rivers Green pepper, 7.5 parts of Oleum Verniciae fordiis, 13 parts of mung bean flours, 4 parts of pearl powders, 4.5 parts of land plasters, 5.5 parts of uva ursis, 6 portions of potatoes, 5.5 portions of bamboos Salt, 250 parts of vaseline.
The preparation method for treating the externally applied drug of dermatitis, includes the following steps：
A) by rhodiola root, the root bark of shaggy-fruited dittany, Long Stephania Herb, peppermint, corn stigma, the tuber of stemona, oriental wormwood, the fruit of summer cypress, pericarpium zanthoxyli, uva ursi, soil Beans dry 3h at 60 DEG C, and 100 mesh screens are crushed after drying, are mixed to get the first mixture, spare；
B) realgar, borneol, sulphur, mung bean flour, pearl powder, land plaster, bamboo salt be crushed into 200 mesh screens, obtains second Mixture, it is spare；
C) step a) is obtained into the first mixture to be added to the mixed of the light-coloured vinegar for being 10% with purity in the white wine that the number of degrees are 60 ° It closes in liquid and impregnates 30h, obtain the second mixture；
D) the second mixture, honey, Oleum Verniciae fordii is added in the first mixture obtained to step c), is uniformly mixing to obtain Three mixtures；
E) vaseline is added in the third mixture obtained to step d), is uniformly mixed to obtain the final product.
Embodiment 6
The externally applied drug for treating dermatitis, includes the raw material of following parts by weight：
28 parts of rhodiola roots, 10 portions of realgars, 12 parts of root bark of shaggy-fruited dittanys, 20 parts of honey, 12 parts of Long Stephania Herbs, 16 portions of peppermints, 9 parts of borneols, 5 Part light-coloured vinegar, 10 parts of corn stigmas, 5.5 parts of tubers of stemona, 6 portions of oriental wormwoods, 20 parts of fruit of summer cypress, 90 parts of white wine, 4 parts of sulphur, 15 parts of asparagus juices, 5 Part pericarpium zanthoxyli, 8.5 parts of Oleum Verniciae fordiis, 11 parts of mung bean flours, 8 parts of pearl powders, 5.5 parts of land plasters, 7.5 parts of uva ursis, 15 parts of potatoes, 6.5 Part bamboo salt, 200 parts of vaseline.
The preparation method for treating the externally applied drug of dermatitis, includes the following steps：
A) by rhodiola root, the root bark of shaggy-fruited dittany, Long Stephania Herb, peppermint, corn stigma, the tuber of stemona, oriental wormwood, the fruit of summer cypress, pericarpium zanthoxyli, uva ursi, soil Beans dry 4h at 50 DEG C, and 200 mesh screens are crushed after drying, are mixed to get the first mixture, spare；
B) realgar, borneol, sulphur, mung bean flour, pearl powder, land plaster, bamboo salt be crushed into 250 mesh screens, obtains second Mixture, it is spare；
C) step a) is obtained into the first mixture to be added to the mixed of the light-coloured vinegar for being 10% with purity in the white wine that the number of degrees are 50 ° It closes in liquid and impregnates 25h, obtain the second mixture；
D) the second mixture, honey, Oleum Verniciae fordii is added in the first mixture obtained to step c), is uniformly mixing to obtain Three mixtures；
E) vaseline is added in the third mixture obtained to step d), is uniformly mixed to obtain the final product.
Embodiment 7
The externally applied drug for treating dermatitis, includes the raw material of following parts by weight：
30 parts of rhodiola roots, 7.5 portions of realgars, 15 parts of root bark of shaggy-fruited dittanys, 15 parts of honey, 11 parts of Long Stephania Herbs, 12 portions of peppermints, 6.5 parts of ice Piece, 3.5 parts of light-coloured vinegars, 8 parts of corn stigmas, 5 parts of tubers of stemona, 9 portions of oriental wormwoods, 22 parts of fruit of summer cypress, 90 parts of white wine, 3 parts of sulphur, 11 portions of aloes Juice, 4 portions of pericarpium zanthoxylis, 8 parts of Oleum Verniciae fordiis, 12 parts of mung bean flours, 6 parts of pearl powders, 4.5 parts of land plasters, 6.5 parts of uva ursis, 10.5 portions of potatoes, 6.5 parts of bamboo salts, 250 parts of vaseline.
The preparation method for treating the externally applied drug of dermatitis, includes the following steps：
A) by rhodiola root, the root bark of shaggy-fruited dittany, Long Stephania Herb, peppermint, corn stigma, the tuber of stemona, oriental wormwood, the fruit of summer cypress, pericarpium zanthoxyli, uva ursi, soil Beans dry 3.5h at 55 DEG C, and 150 mesh screens are crushed after drying, are mixed to get the first mixture, spare；
B) realgar, borneol, sulphur, mung bean flour, pearl powder, land plaster, bamboo salt be crushed into 250 mesh screens, obtains second Mixture, it is spare；
C) step a) is obtained into the first mixture to be added to the mixed of the light-coloured vinegar for being 10% with purity in the white wine that the number of degrees are 50 ° It closes in liquid and impregnates 25h, obtain the second mixture；
D) the second mixture, honey, Oleum Verniciae fordii is added in the first mixture obtained to step c), is uniformly mixing to obtain Three mixtures；
E) vaseline is added in the third mixture obtained to step d), is uniformly mixed to obtain the final product.
One, safety testing：
The product mix of Example 1~7.
It is that experiment is dynamic with the small white mouse of weight 18-20g half male and half females using the hybrid medicine of above-mentioned gained as trial drug Object, is divided into 5 groups by totally 150, respectively the drug of gavage various concentration, concentration be respectively 10mg/ml, 40mg/ml, 60mg/ml, 80mg/ml, 100mg/ml, administered volume are 40ml/kg, to gastric infusion in mouse one day 3 times, accumulate gastric infusion volume For 100ml/kg.Observation 7 days has no overt toxicity reaction and the reaction of pawpaw enteron aisle.Through visually observing after dissection, main organs Non Apparent Abnormality.
The small white mouse of weight 18-20g half male and half females is experimental animal, totally 80, is divided into two groups, carries out long term toxicity examination It tests, one group of administration concentration is 60mg/ml, administered volume 40ml/kg；Another group is isometric distilled water, continuously gavages 3 A month, carry out long term toxicity test.Long term toxicity test the results show that general behavior activity and the body weight increase of experimental animal just Often, to hematological indices, the organ coefficient of hepatic and renal function and main organs all has no significant effect, and main organs are damaged without apparent pathology Wound shows drug nontoxicity.
Two, the externally applied drug for the treatment dermatitis for obtaining Examples 1 to 7 carries out clinical test, as a result as follows：
1, subject selects：The skin allergy patient totally 800 in March, 2011~certain hospital accepts for medical treatment so far is selected, wherein Male patient 400, female patient 400.
2, packet design：All patients are randomly divided into eight groups, respectively experimental group 1, experimental group 2, experimental group 3, experimental group 4, experimental group 5, experimental group 6, experimental group 7 and control group, each 100, eight groups of patients are at age, the state of an illness etc. without significance difference It is different, it is comparable.Wherein experimental group 1~7 uses the externally applied drug of the treatment dermatitis of Examples 1 to 7 preparation respectively.
3, instructions of taking：The externally applied drug of the treatment dermatitis of Examples 1 to 7 is spread on dermatitis lesion by experimental group 1~7 respectively Go out, it is secondary daily, it is continuous to apply 7 days.Control group uses other drugs (such as acyclovir ointment).
4, curative effect judging standard
It cures：Patient's dermatitis symptom disappears, and body surface restores normal；
Effectively：Patient's dermatitis symptom gradually mitigates or symptom disappears；
In vain：Dermatitis symptom is without improvement；
Total effective rate=(curing number of cases+effective number of cases)/case load.
5, the results are shown in Table 1
The treatment results of table 1 experimental group 1~7 and control group
Above description enables professional and technical personnel in the field to realize or using this to being stated in the disclosed embodiments It is bright, it enables those skilled in the art to implement or use the present invention.Various modifications to these embodiments are to this field It will be apparent for professional technician, the general principles defined herein can be in the spirit for not departing from the present invention Or in the case of range, realize in other embodiments.Therefore, the present invention is not intended to be limited to these implementations shown in this article Example, and it is to fit to the widest range consistent with principles disclosed herein and novel features.

Claims (5)

1. a kind of externally applied drug for treating dermatitis, which is characterized in that include the raw material of following parts by weight：
2. the externally applied drug for the treatment of dermatitis as described in claim 1, which is characterized in that include the raw material of following parts by weight：
。
3. the externally applied drug for the treatment of dermatitis as described in claim 1, which is characterized in that further include vaseline, the vaseline Parts by weight are 200~300 parts.
4. the externally applied drug for the treatment of dermatitis as described in claim 1, which is characterized in that the number of degrees of the white wine are 40~60 °.
5. a kind of preparation method of externally applied drug that treating dermatitis such as Claims 1 to 4 any one of them, which is characterized in that packet Include following steps：
A) rhodiola root, the root bark of shaggy-fruited dittany, Long Stephania Herb, peppermint, corn stigma, the tuber of stemona, oriental wormwood, the fruit of summer cypress, pericarpium zanthoxyli, uva ursi, potato are existed 50~60 DEG C of 3~4h of drying, crushed 100~200 mesh screens, are mixed to get the first mixture after drying, spare；
B) realgar, borneol, sulphur, mung bean flour, pearl powder, land plaster, bamboo salt be crushed into 200~300 mesh screens, obtains second Mixture, it is spare；
C) by step a) obtain the first mixture be added in white wine and the mixed liquor of light-coloured vinegar in impregnate 20~30h, obtain second Mixture；
D) the second mixture, honey, Oleum Verniciae fordii is added in the first mixture obtained to step c), it is mixed is uniformly mixing to obtain third Close object；
E) vaseline is added in the third mixture obtained to step d), is uniformly mixed to obtain the final product.
CN201810746035.8A 2018-07-09 2018-07-09 A kind of externally applied drug and preparation method thereof for treating dermatitis Withdrawn CN108524847A (en)

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