CN108524760B - 一种用于治疗周围血管疾病的中药复方制剂及其制备方法 - Google Patents
一种用于治疗周围血管疾病的中药复方制剂及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种用于治疗周围血管疾病的中药复方制剂及其制备方法,属于中药制药技术领域,中药复方制剂包括以下重量份数的原料组分:丹参10~30份,川芎5~15份,远志3~9份,麦冬3~12份,血竭3~9份,葛根3~12份,佛手6~20份,三七8~16份,银杏叶3~15份,钩藤3~9份,荆芥4~10份,当归3~8份,何首乌3~7份,没药3~9份,决明子4~8份。本发明提供的中药复方制剂应用范围广,可用于血栓闭塞性脉管炎、闭塞性动脉粥样硬化、下肢深静脉血栓形成、血栓性浅静脉炎、雷诺氏病等,并且使用方便、见效快、复发性低。
Description
技术领域
本发明属于中药制药技术领域,具体涉及一种用于治疗周围血管疾病的中药复方制剂及其制备方法。
背景技术
周围血管疾病是外周血管病的通称,主要包括血栓闭塞性脉管炎、闭塞性动脉粥样硬化、下肢深静脉血栓形成、血栓性浅静脉炎、雷诺氏病、大动脉炎,以及下肢静脉曲张、深静脉瓣膜功能不全所致的淤血肿胀、淤积性皮炎、继发感染,丹毒、象皮肿等。虽然其发病原因、病理变化和临床特点有所不同,但都存在血瘀共性,表现为瘀血、缺血、瘀斑、肿胀、粥样斑块、血栓形成、血管狭窄或闭塞,甚至出现溃疡或坏疽。经过历代医家在不同时期的临床实践,发展形成独特的理论体系和特有的治疗方法,积累了丰富的临床经验。
目前,周围血管疾病的外治疗法较多,有膏药疗沙、围敷疗法、掺药疗法、热熨疗法等,而熏洗疗法是常用的外治疗法之一,应用活血化癖法治疗周围血管疾病,具有多方面治疗作用,但现有技术中用于熏洗疗法的药物尚存在治疗效果不理想、成本较高等缺陷,需要一种治疗效果更好的药物。
发明内容
本发明的目的在于克服现有技术的不足,提供一种用于治疗周围血管疾病的中药复方制剂及其制备方法。
为实现上述目的,本发明采用的技术方案如下:
一种用于治疗周围血管疾病的中药复方制剂,包括以下重量份数的原料组分:丹参10~30份,川芎5~15份,远志3~9份,麦冬3~12份,葛根3~12份,佛手6~20份,三七8~16份,银杏叶3~15份,钩藤3~9份,荆芥4~10份,当归3~8份,何首乌3~7份,没药3~9份,决明子4~8份、臭梧桐4~10份。
本发明的特点还在于,本发明提供的用于治疗周围血管疾病的中药复方制剂,包括以下重量份数的原料组分:丹参25份,川芎15份,远志5份,麦冬8份,葛根10份,佛手12份,三七15份,银杏叶15份,钩藤4份,荆芥4份,当归5份,何首乌7份,没药6份,决明子5份,臭梧桐8份。
本发明的特点还在于,中药复方制剂的药用剂型为煎剂。
本发明的另一技术方案是提供一种上述中药复方制剂的制备方法,包括如下步骤:
S1、取丹参、川芎、远志、麦冬、葛根、佛手、三七、银杏叶、钩藤、荆芥、当归、何首乌、没药、决明子、臭梧桐,净选,干燥;
S2、按重量份称取S1中所述的制备原料药;
S3、将各原料药加水煎煮3次得到煎液,合并各煎液并过滤,过滤后提取滤液,减压浓缩滤液至60~90℃下的相对密度为1.12~1.28,放冷,即得到所述治疗周围血管疾病的中药复方制剂。
本发明的特点还在于,在S3中,第一次加水量为药材量的8倍,煎煮2~4小时,第二次加水量为药材量的6倍,煎煮2~3小时,第三次加水量为药材量的4倍,煎煮1~2小时。
本发明中各主要原料药的功效活性:
丹参:味苦、性微寒,归心、肝经;具有活血散淤、消肿止血、消炎止痛、调经止痛、扩张冠状动脉、改善心肌缺血状况、降低血压、安神静心、降血糖和抗菌等功效,用于治疗胸痹心痛,脘腹胁痛,热痹热痛,心烦不眠,此外,近代医学实验证明,丹参还具有抗血小板凝聚、降低血液黏度及调节内外凝血系统的功能。
川芎:味辛,性温,归肝、心经;具有能扩张冠状动脉,增加冠状动脉血流量,改善心肌的血氧供应,并降低心肌的耗氧量,能够扩张脑血管,降低血管阻力,显著增加脑及肢体血流量,改善微循环;能降低血小板表面活性,抑制血小板凝集,预防血栓的形成。
远志:味苦、辛,性温,归心、肾、肺经;具有安神益智、祛痰、消肿之功效,用于治疗惊悸,健忘,梦遗,失眠,咳嗽多痰,痈疽疮肿等症。
麦冬:味微苦,性微寒,归胃、肺、心经;具有养阴润肺、益胃生津、清心除烦的功效,用于肺燥干咳、阴虚痨嗽、喉痹咽痛、津伤口渴、内热消渴、心烦失眠、肠燥便秘等症。
葛根:味甘,性凉,具有清热、降火、排毒、强化肝胆细胞自身免疫功能、抵抗病毒入侵、延缓衰老、调节血脂血糖之功效,用于治疗心肌缺血和脑缺血状态,防治冠心病、心绞痛、心肌梗塞、脑梗塞、偏瘫、血管性痴呆等脑血管疾病。
佛手:具有疏肝解郁,理气和中,燥湿化痰,降血糖、血压等功效,用于治疗肝郁气滞之胸胁胀痛,肝胃不和,脾胃气滞,呕恶食少等病症。
三七:味甘、微苦,性温,归肝、胃经;具有散瘀止血,消肿定痛之功效,用于治疗咯血,吐血,衄血,便血,崩漏,外伤出血,胸腹刺痛,跌扑肿痛等症。
银杏叶:味甘、苦、涩,性平,归心、肺经;具有敛肺,平喘,活血化瘀,止痛等功效,用于治疗高血压,动脉硬化,大动脉炎,闭塞性脉管炎,心绞痛,心肌梗死,脑栓塞,再生障碍性贫血等症。
钩藤:味甘、苦,性微寒,归肝、心经;具有清热平肝,熄风止痉的功效,用于治疗肝火上逆头痛目赤,肝阳上亢头晕目眩,热盛动风惊痫,小儿惊风,夜啼,子痫,中风瘫痪,肢节挛急等症。
荆芥:味辛、微苦,性微温,归肺、肝经;具有祛风,解表,透疹,止血之功效,用于治疗感冒发热、头痛、目痒、咳嗽、咽喉肿痛、麻疹、痈肿、疮疥、衄血、吐血、便血、崩漏等症。
当归:味甘、辛、苦,性温,归肝、心、脾经;具有补血、活血、调经止痛、润燥滑肠之功效,用于治疗血虚、月经不调、虚寒腹痛、肌肤麻木、肠燥便难等症。
何首乌:味苦、涩,性温,归脾、肺、肾经;具有补肝肾、益精血、强筋骨、乌发、安神、止汁等功效;用于治疗血虚、头昏目眩、体倦乏力、萎黄、肝肾精血亏虚、眩晕耳鸣、腰漆酸软、须发早白、高血脂等症。
没药:味苦,性平,归肝、脾、心、肾经;具有散血去瘀,消肿定痛等功效,用于治疗跌打损伤、金疮、筋骨、心腹诸痛、症瘕、经闭、痈疽肿痛、痔漏、目障等症。
决明子:味苦,性微寒,归肝、大肠经;具有清热明目,润肠通便等功效,用于治疗目赤涩痛,羞明多泪,头痛眩晕,目暗不明,大便秘结,高血压等症。
臭梧桐:具有降压、镇痛、镇静、抗炎的功效,主治风湿痹痛,半身不遂,高血压病,偏头痛;疟疾,痢疾,痔疮,痈疽疮疥等症。
本发明具有的优点和积极效果是:
本发明提供的用于治疗周围血管疾病的中药复方制剂具有活血化瘀、清热平肝、滋肾健脾、安神益智的功效,以丹参、川芎、三七、银杏叶、没药为君药,起到活血化瘀、消肿定痛的作用,以麦冬、葛根、钩藤、荆芥为臣药,起到清热平肝、疏肝解郁的作用,以当归、何首乌、佛手为佐药,起到滋肾健脾、去湿化痰的作用,以远志、决明子、臭梧桐为使药,起到安神益智、润肠通便的作用,诸药合用协同起效,在活血化瘀的同时,还能够调理气血,对于血栓闭塞性脉管炎、闭塞性动脉粥样硬化、下肢深静脉血栓形成、血栓性浅静脉炎、雷诺氏病等疾病的治疗效果明显,且本发明的复方制剂取材于中草药,无毒副作用,患者顺应性好,治疗费用低,见效快;同时该中药复方制剂为煎剂,患者通过熏洗进行治疗,使用方便。
具体实施方式
为了使本领域技术人员更好地理解本发明的技术方案能予以实施,下面结合具体实施例对本发明作进一步说明,但所举实施例不作为对本发明的限定。
下面各实施例中未注明具体条件的试验方法,均按照本领域的常规方法和条件进行,所用原料均为市售。
实施例1
本实施例提供的一种用于治疗周围血管疾病的中药复方制剂,具体包括以下重量份数的原料组分:丹参25份,川芎15份,远志5份,麦冬8份,葛根10份,佛手12份,三七15份,银杏叶15份,钩藤4份,荆芥4份,当归5份,何首乌7份,没药6份,决明子5份,臭梧桐8份。
本发明实施例的用于治疗周围血管疾病的中药复方制剂的制备方法,具体包括如下步骤:
S1、取丹参、川芎、远志、麦冬、葛根、佛手、三七、银杏叶、钩藤、荆芥、当归、何首乌、没药、决明子、臭梧桐,净选,干燥;
S2、按重量份称取S1中所述的制备原料药;
S3、将各原料药加水煎煮3次得到煎液,第一次加水量为药材量的8倍,煎煮4小时,第二次加水量为药材量的6倍,煎煮3小时,第三次加水量为药材量的4倍,煎煮2小时,然后合并各煎液并过滤,过滤后提取滤液,减压浓缩滤液至90℃下的相对密度为1.28,放冷,即得到所述治疗周围血管疾病的中药复方制剂。
实施例2
本实施例提供的一种用于治疗周围血管疾病的中药复方制剂,具体包括以下重量份数的原料组分:丹参20份,川芎12份,远志9份,麦冬5份,葛根12份,佛手15份,三七8份,银杏叶6份,钩藤3份,荆芥5份,当归3份,何首乌4份,没药9份,决明子4份,臭梧桐7份。
本发明实施例的用于治疗周围血管疾病的中药复方制剂的制备方法,具体包括如下步骤:
S1、取丹参、川芎、远志、麦冬、葛根、佛手、三七、银杏叶、钩藤、荆芥、当归、何首乌、没药、决明子、臭梧桐,净选,干燥;
S2、按重量份称取S1中所述的制备原料药;
S3、将各原料药加水煎煮3次得到煎液,第一次加水量为药材量的8倍,煎煮3小时,第二次加水量为药材量的6倍,煎煮2小时,第三次加水量为药材量的4倍,煎煮1小时,然后合并各煎液并过滤,过滤后提取滤液,减压浓缩滤液至75℃下的相对密度为1.21,放冷,即得到所述治疗周围血管疾病的中药复方制剂。
实施例3
本实施例提供的一种用于治疗周围血管疾病的中药复方制剂,具体包括以下重量份数的原料组分:丹参18份,川芎12份,远志7份,麦冬12份,葛根8份,佛手13份,三七12份,银杏叶9份,钩藤8份,荆芥6份,当归5份,何首乌3份,没药5份,决明子7份,臭梧桐4份。
本发明实施例的用于治疗周围血管疾病的中药复方制剂的制备方法,具体包括如下步骤:
S1、取丹参、川芎、远志、麦冬、葛根、佛手、三七、银杏叶、钩藤、荆芥、当归、何首乌、没药、决明子、臭梧桐,净选,干燥;
S2、按重量份称取S1中所述的制备原料药;
S3、将各原料药加水煎煮3次得到煎液,第一次加水量为药材量的8倍,煎煮4小时,第二次加水量为药材量的6倍,煎煮3小时,第三次加水量为药材量的4倍,煎煮2小时,然后合并各煎液并过滤,过滤后提取滤液,减压浓缩滤液至60℃下的相对密度为1.12,放冷,即得到所述治疗周围血管疾病的中药复方制剂。
实施例1~3均制备出了效果良好的用于治疗周围血管疾病的中药复方制剂,由于实施例1~3制备出的治疗周围血管疾病的中药复方制剂效果基本平行,因此仅采用实施例1制备出的中药复方制剂来对本发明的效果进行说明。
1、临床案例
(1)本发明对200例血栓闭塞性脉管炎的患者进行临床观察治疗,其中男性87例,女性113例,年龄最大70岁,最小21岁,病程4年以内不等,其中,半年以内90例,半年~1年18例,1~2年45例,2~3年25例,3~4年22例;发病诱因:有吸烟史76例,冻伤史88例,诱因不明36例。
(2)本发明对150例血栓性浅静脉炎的患者进行临床观察治疗,其中男性68例,女性82例,年龄最大65岁,最小23岁,病程6个月以内不等,其中,1~2周40例,2周~1个月58例,1~2个月27例,2~6个月25例;发病诱因:静脉曲张史25例,静脉点滴治疗史30例,阴冷潮湿环境工作史8例,诱因不明87例。
(3)本发明对100例深静脉血栓的患者进行临床观察治疗,其中男性47例,女性53例,年龄最大25岁,最小67岁,病程12年以内不等,其中,1年以内32例,1~2年38例,2~3年21例,3年以上9例;发病诱因:剖腹产史6,诱因不明94例。
(4)本发明对15例动脉硬化性闭塞症的患者进行临床观察治疗,其中男性6例,女性9例,年龄最大55岁,最小37岁,病程5年以内不等,其中,1~2年4例,2~3年6例,3年以上5例;发病诱因均不明。
(5)本发明对9例雷诺氏病的患者进行临床观察治疗,均为40岁以上女性,病程1年以上6例,3年以上3例,均有月经不调及寒冷刺激后病情加重史。
2、治疗方法
治疗期间使用本发明实施例1制备出的煎剂,使用时,取100~150ml,加开水至1000ml,熏洗患处,每日2次,每次15~25min,治疗周期为4周。
3、治疗效果评价:
治愈:治疗后症状消失,各项检查指标恢复正常。
显效:治疗后症状较治疗前明显减少,各项检查指标基本恢复正常。
有效:治疗后症状有所减少,各项指标改善。
无效:治疗后各症状无明显改善。
4、实验结果
200例血栓闭塞性脉管炎患者治愈的60例,占30%,显效的85例,占42.5%,有效的38例,占19%,无效的17例,占8.5%,总有效率达91.5%。
150例血栓性浅静脉炎患者治愈的60例,占40%,显效的45例,占30%,有效的37例,占24.7%,无效的8例,占5.3%,总有效率达94.7%。
100例深静脉血栓的患者治愈的62例,占62%,显效的18例,占18%,有效的17例,占17%,无效的3例,占3%,总有效率达97%。
15例动脉硬化性闭塞症患者治愈的7例,占46.7%,显效的3例,占20%,有效的4例,占26.7%,无效的1例,占6.7%,总有效率达93.4%。
9例雷诺氏病的患者治愈的5例,占55.6%,显效的3例,占33.3%,有效的1例,占11.1%,无效的0例,总有效率达100%。
综上,本发明所述的中药组方合理、成本低、药物取材方便、制剂简易、疗程短、疗效显著、治愈率高、无毒副作用。
需要说明的是,本发明权利要求书中涉及数值范围时,应理解为每个数值范围的两个端点以及两个端点之间任何一个数值均可选用,由于采用的步骤方法与实施例1~3相同,为了防止赘述,本发明的描述了优选的实施例,但本领域内的技术人员一旦得知了基本创造性概念,则可对这些实施例作出另外的变更和修改。所以,所附权利要求意欲解释为包括优选实施例以及落入本发明范围的所有变更和修改。
显然,本领域的技术人员可以对本发明进行各种改动和变型而不脱离本发明的精神和范围。这样,倘若本发明的这些修改和变型属于本发明权利要求及其等同技术的范围之内,则本发明也意图包含这些改动和变型在内。
Claims (5)
1.一种用于治疗周围血管疾病的中药复方制剂,其特征在于,由以下重量份数的原料组分制成:丹参10~30份,川芎5~15份,远志3~9份,麦冬3~12份,葛根3~12份,佛手6~20份,三七8~16份,银杏叶3~15份,钩藤3~9份,荆芥4~10份,当归3~8份,何首乌3~7份,没药3~9份,决明子4~8份,臭梧桐4~10份,所述周围血管疾病为血栓闭塞性脉管炎、血栓性浅静脉炎、深静脉血栓、动脉硬化性闭塞症或雷诺氏病。
2.根据权利要求1所述的一种用于治疗周围血管疾病的中药复方制剂,其特征在于,由以下重量份数的原料制成:丹参25份,川芎15份,远志5份,麦冬8份,葛根10份,佛手12份,三七15份,银杏叶15份,钩藤4份,荆芥4份,当归5份,何首乌7份,没药6份,决明子5份,臭梧桐8份。
3.根据权利要求1所述的一种用于治疗周围血管疾病的中药复方制剂,其特征在于,所述中药复方制剂的药用剂型为煎剂。
4.一种制备权利要求1所述的用于治疗周围血管疾病的中药复方制剂的制备方法,其特征在于,包括如下步骤:
S1、取丹参、川芎、远志、麦冬、葛根、佛手、三七、银杏叶、钩藤、荆芥、当归、何首乌、没药、决明子、臭梧桐,净选,干燥;
S2、按重量份称取S1中所述的制备原料药;
S3、将各原料药加水煎煮3次得到煎液,合并各煎液并过滤,过滤后提取滤液,减压浓缩滤液至60~90℃下的相对密度为1.12~1.28,放冷,即得到所述治疗周围血管疾病的中药复方制剂。
5.根据权利要求4所述的一种用于治疗周围血管疾病的中药复方制剂的制备方法,其特征在于,在S3中,第一次加水量为药材量的8倍,煎煮2~4小时,第二次加水量为药材量的6倍,煎煮2~3小时,第三次加水量为药材量的4倍,煎煮1~2小时。
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