CN108524619A - Radix Paeoniae Alba is fresh to carry spray-dried granules medicine materical crude slice - Google Patents
Radix Paeoniae Alba is fresh to carry spray-dried granules medicine materical crude slice Download PDFInfo
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- CN108524619A CN108524619A CN201810733166.2A CN201810733166A CN108524619A CN 108524619 A CN108524619 A CN 108524619A CN 201810733166 A CN201810733166 A CN 201810733166A CN 108524619 A CN108524619 A CN 108524619A
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- Prior art keywords
- radix paeoniae
- paeoniae alba
- materical crude
- crude slice
- medicine materical
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
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Abstract
The invention discloses a kind of " Radix Paeoniae Alba is fresh to carry spray-dried granules medicine materical crude slice ", are primarily characterized in that：Radix Paeoniae Alba harvest after, take advantage of it is fresh wash, be sliced, squeezing the juice, extracting, extracting solution concentrate after be spray-dried, granulation, whole grain, vacuum packaging.The water content of granule pieces is less than 10%.This prepared slice quality is stablized, and can both enter decoction decocting, can also directly enter in capsule, tablet, is conducive to carry, Clinical practice is convenient.
Description
Technical field
The invention belongs to prepared slices of Chinese crude drugs technical fields, especially belong to the manufacture field of radix paeoniae alba decoction pieces.
Background technology
Chinese medicine Radix Paeoniae Alba is cohosh Chinese herbaceous peonyPaeonia lactifloraPall. dry root has blood-nourishing tune
Through, astringing YIN to stop sweating, the effect of soft liver analgesic, suppressing liver-YANG.For blood deficiency chlorosis, irregular menstruation, spontaneous perspiration, night sweat, hypochondriac pain, abdomen
Bitterly, four limbs contraction pain, the treatment of dizziness of having a headache etc. are a herbs common on tcm clinical practice.The processing method of traditional Radix Paeoniae Alba is：
It after medicinal material is excavated, cleans, removes end to end and radicula, set and boiled again after removing crust or peeling after being boiled in boiling water, dry, be packaged,
Storage and transportation.To after medicine materical crude slice factory, then washs, softens, is sliced, dries, packs.Thus obtained radix paeoniae alba decoction pieces volume is big, hygiene mark
It is accurate poor, it is easy to make moist, is mildew, infested, is unfavorable for taking care of, storage and transportation cost height.In addition, such prepared slice quality stability
Difference, clinical efficacy be difficult to ensure, patient takes inconvenience, works slow.Therefore, develop that a kind of stable quality is reliable, storage/transportation
It is at low cost, conducive to keeping, carry and easy to use, rapid-action novel radix paeoniae alba decoction pieces, it is imperative.Existing market Radix Paeoniae Alba drinks
Piece, other than traditional medicine materical crude slice, also two kinds of forms of Ultramicro-powder medicine materical crude slice and concentrated granular medicine materical crude slice, but both with traditional medicine materical crude slice
For raw material, quality is decided by the quality of traditional medicine materical crude slice, and ultramicro decoction piece cannot solve the problems, such as that medicinal material pollutes；Concentrated granular is only
Water-soluble components can be extracted.
Invention content
The invention discloses a kind of " Radix Paeoniae Alba is fresh to carry spray-dried granules medicine materical crude slice ", are primarily characterized in that：It is harvested in Radix Paeoniae Alba
Afterwards, it cleaning in time, crust is cleaned and scraped off to impurity and the dis-medicinal part such as removal silt in taking advantage of using fresh herb tap water in 24 hours,
It is cut into the piece of 2 ~ 5mm thickness.The piece that this cuts is added in the water of 1 ~ 5 times of 50 ~ 70 DEG C of weight, impregnate and constantly stirs 5 ~ 30 points
Clock, filtering, dregs pressing take juice.The water that 5 ~ 10 times of weight is added in the gained dregs of a decoction is boiled 10 ~ 30 minutes, is filtered while hot, medicine
Slag is squeezed the juice again, collects concoction.Merge above-mentioned concoction, crosses 60 ~ 100 mesh sieve, be concentrated under reduced pressure, temperature is 50 ~ 75 DEG C, is concentrated into phase
The concentrate for being 1.02 ~ 1.10 to density.Gained concentrate leaves and takes 1% ~ 3% spare, remaining spray drying.By the spray powder of collection
With spare concentrate mixing granulation, dry to be less than 10% to water content, whole grain is vacuum-packed to get finished product.Finished product medicine materical crude slice contains
Paeoniflorin（C23H28O11) 3.0% must not be less than.Radix Paeoniae Alba granule pieces stable quality, good fluidity, clinical general usage amount is 1 ~
5g.Such medicine materical crude slice can both enter decoction decoction, take after mixing it with water, and also can directly enter in capsule and tablet, make to substantially increase clinic
Convenience and compliance are conducive to the treatment of clinical acute disease.
The present invention solve traditional radix paeoniae alba decoction pieces are bulky, carrying cost is high, be unfavorable for keeping, easily mildew it is infested, defend
The shortcomings such as the poor, unstable quality of raw condition, due to being to take advantage of fresh extraction, quality is drunk than ultramicro grinding medicine materical crude slice and concentrated granular
Piece is more preferable.
Specific embodiment
It after white Peony Root is harvested, cleans, removes impurity and the dis-medicinal parts such as silt, using fresh herb is taken advantage of in 6 hours originally
Water is cleaned, and scrapes off crust, is cut into the piece of 3mm thickness.This piece is added to 70 DEG C of pure water of 5 times of weight, is stirred 30 minutes, mistake
Filter, dregs pressing take juice.The pure water for adding 8 times of weight into the above-mentioned dregs of a decoction again is boiled 20 minutes and is extracted, filters while hot,
The dregs of a decoction are squeezed the juice again, collect concoction.Merge above-mentioned concoction, be concentrated under reduced pressure, temperature is to be set as 70 DEG C, and being concentrated into relative density is
1.05.The concentrate of gained is left and taken into 3% spare, remaining spray drying.Spray powder is collected, system is mixed with spare concentrate
Particle, it is 10% that 80 DEG C, which are dried under vacuum to water content, and whole grain is vacuum-packed to get finished product.Finished product medicine materical crude slice contains Paeoniflorin
（C23H28O11) it is 3.6%.
Claims (2)
1. a kind of Radix Paeoniae Alba is fresh to carry spray-dried granules medicine materical crude slice, it is primarily characterized in that：It after Radix Paeoniae Alba harvests, cleans, removes in time
The impurity such as silt and dis-medicinal part are cleaned and are scraped off crust in taking advantage of using fresh herb tap water in 24 hours, be cut into the piece of 2 ~ 5mm thickness,
The water of 1 ~ 5 times of 50 ~ 70 DEG C of weight is added, impregnate and constantly stirs 5 ~ 30 minutes, filtering, dregs pressing takes juice；In the gained dregs of a decoction
The water for adding 5 ~ 10 times of weight is boiled 10 ~ 30 minutes, is filtered while hot, and the dregs of a decoction are squeezed the juice again, collects concoction；Merge above-mentioned medicine
Juice is crossed 60 ~ 100 mesh sieve, is concentrated under reduced pressure, and temperature is 50 ~ 75 DEG C, and it is 1.02 ~ 1.10 to be concentrated into relative density；Gained concentrate stays
Take 1% ~ 3% spare, remaining spray drying；By the spray powder of collection and spare concentrate mixing granulation, drying is low to water content
In 10%, whole grain is vacuum-packed to get finished product；Finished product medicine materical crude slice contains Paeoniflorin（C23H28O11) content must not be less than 3.0%.
2. Radix Paeoniae Alba according to claim 1 is fresh to carry spray-dried granules medicine materical crude slice, it is primarily characterized in that：Clinic generally uses
Amount is 1 ~ 5g, this medicine materical crude slice can both enter decoction decoction, take after mixing it with water, and also can directly enter in capsule and tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810733166.2A CN108524619A (en) | 2018-07-06 | 2018-07-06 | Radix Paeoniae Alba is fresh to carry spray-dried granules medicine materical crude slice |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810733166.2A CN108524619A (en) | 2018-07-06 | 2018-07-06 | Radix Paeoniae Alba is fresh to carry spray-dried granules medicine materical crude slice |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108524619A true CN108524619A (en) | 2018-09-14 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810733166.2A Pending CN108524619A (en) | 2018-07-06 | 2018-07-06 | Radix Paeoniae Alba is fresh to carry spray-dried granules medicine materical crude slice |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150164971A1 (en) * | 2012-07-03 | 2015-06-18 | Eu Yan Sang International Ltd | Seven-star tea without excipient and method of preparing the same |
| CN106109530A (en) * | 2016-07-23 | 2016-11-16 | 徐漫 | A kind of Folium Isatidis fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN107281247A (en) * | 2017-08-25 | 2017-10-24 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of eclipta |
| CN107281236A (en) * | 2017-06-19 | 2017-10-24 | 徐漫 | A kind of Ilex Latifolia Thunb is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology |
| CN107320508A (en) * | 2017-08-25 | 2017-11-07 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of Chinese trumpet creeper |
| CN107468751A (en) * | 2017-08-25 | 2017-12-15 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of Longtube Ground Ivy Herb |
-
2018
- 2018-07-06 CN CN201810733166.2A patent/CN108524619A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150164971A1 (en) * | 2012-07-03 | 2015-06-18 | Eu Yan Sang International Ltd | Seven-star tea without excipient and method of preparing the same |
| CN106109530A (en) * | 2016-07-23 | 2016-11-16 | 徐漫 | A kind of Folium Isatidis fresh squeezing spray-dried granules decoction pieces and preparation technology thereof |
| CN107281236A (en) * | 2017-06-19 | 2017-10-24 | 徐漫 | A kind of Ilex Latifolia Thunb is fresh to squeeze spray-dried granules medicine materical crude slice and its preparation technology |
| CN107281247A (en) * | 2017-08-25 | 2017-10-24 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of eclipta |
| CN107320508A (en) * | 2017-08-25 | 2017-11-07 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of Chinese trumpet creeper |
| CN107468751A (en) * | 2017-08-25 | 2017-12-15 | 芜湖天成普阳中药科技有限公司 | A kind of fresh preparation technology for squeezing spray-dried granules medicine materical crude slice of Longtube Ground Ivy Herb |
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Application publication date: 20180914 |
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