CN108514617A

CN108514617A - A kind of spina date seed oral solution and preparation method thereof improving sleep quality

Info

Publication number: CN108514617A
Application number: CN201810471850.8A
Authority: CN
Inventors: 高鹏; 李少华; 秦令祥; 崔胜文; 唐雪燕; 高愿军
Original assignee: Henan Sunset Blue Food Technology Co Ltd
Current assignee: Henan Sunset Blue Food Technology Co Ltd
Priority date: 2018-05-17
Filing date: 2018-05-17
Publication date: 2018-09-11

Abstract

The invention discloses a kind of spina date seed oral solutions and preparation method thereof improving sleep quality, it is composed of the following raw materials in parts by weight, 100 150 parts of spina date seed, 60 80 parts of gynostemma pentaphylla, 60 80 parts of Radix Notoginseng, 50 70 parts of prepared rehmannia root, 50 70 parts of monkshood, 50 70 parts of barley young leaf powder, 50 70 parts of Kiwi berry etc. and 0.5 1 parts of stabilizer, 24 parts of flavoring agent.Characteristic and mutual conspiracy relation of the present invention according to raw material have obtained the proportioning between best raw material by the experience accumulated all the year round and a large amount of experiment and contrast test, have obtained the prescription for reaching by dispersing stagnated hepatoqi and improving sleeper effect；Proportioning is reasonable, significant effect.

Description

A kind of spina date seed oral solution and preparation method thereof improving sleep quality

Technical field

The present invention relates to the field of Chinese medicines, more particularly, to a kind of spina date seed oral solution improving sleep quality and its preparation side Method.

Background technology

Spina date seed, Chinese medicine name.Spina date seed Ziziphi Spinosae Semen are Rhamnaceae Rhamnaceae) plant wild jujube The dry mature kernal of Ziziphus jujuba Mill.var.spinosa (Bunge) Hu ex H.F.Chou, have tonifying liver, Arrest sweating, calming heart, the function of promoting the production of body fluid are used for the cards such as restlessness of asrhenia type and insomnia, body void hidrosis, horrified to much dream, injury thirst,《Compendium of Materia Medica》It will It is classified as top grade.Spina date seed is a kind of curative for effect, small Chinese medicine of adverse reaction, is clinically used for treatment multiple types insomnia And neurasthenia.Both it was《Chinese Pharmacopoeia》It is recorded, it is also possible to make raw-food material.

It is analyzed by chemical constitution study and assay, the results showed that spina date seed principle active component is the master of spina date seed Chemical composition is wanted to have saponins, flavonoids, alkaloids etc..Modern pharmacological studies have shown that saponins and flavonoids in spina date seed Close the principle active component that object is its tranquilizing soporific.Wherein Saponin A and spinosin be《Chinese Pharmacopoeia》Version in 2010 The active constituent of the spina date seed of defined, betulic acid are also concerned with its antitumor activity.Zhang Qiaoyue etc., HPLC-MS method Measure 9 kinds of ingredients in spina date seed simultaneously.

Spina date seed sees Han dynasty Zhang Zhongjing at square suanzaoren decoction head《Synopsis Golden Chamber blood-arthralgia Virtual labor diseases》In, side is by acid Jujube kernel, Rhizoma Chuanxiong, rhizoma anemarrhenae, Poria cocos, Radix Glycyrrhizae composition.In former book, we, which are mainly used to treat Virtual labor Virtual, must not be tired of the card slept, this side It embodies《The Yellow Emperor's Canon of Internal Medicine》Main idea is verified through ancient Chinese medicine doctor, there is more definite curative effect.Its main ingredient spina date seed is mild-natured, sour, enters Liver, courage, the heart, spleen, warp, work(arrogate to oneself nourishing the liver, calming heart, tranquilizing the mind.《Plain Questions six saves state of internal organs opinion》Cloud：Liver person's source of endurance, the residence of soul also its It is sour.《Plain Questions the five internal organs generate a piece》Also have：The opinion of the liver having a preference for sour flavor, therefore it is monarch drug in a prescription that spina date seed is reused in side.Shanxi Tao Hongjing《Name doctor is other Record》The vexatious Virtual sweat polydipsia that must not sleep of cloud we master, bowl spares, beneficial irritability.Bright merchant is learned《Drugization justice》Cloud：Jujube kernel, the main benefit of benevolence, skin Invigorating heart blood.Its gas stir-fries, turns to tepor, by perfume (or spice) with the saturating motive.It obtains warm to help the mind.All will hardship blood troubles damage god with intelligence, cause heart Virtual Deficiency, palpitation with fear palpitation, dimly more is forgotten, Virtual sweat polydipsia, works as and must use spirit fall.Fragrant Wen Yiwen livers, courage are taken again.If courage Virtual blood Less, dysphoria and insomnia makes liver, courage hemapodium with this, then the five internal organs pacify and doss rather.Clear Miao Xiyong《Sheng Nong's herbal classic is dredged》Cloud：Wild jujube The special tonifying liver courage of benevolence is also amusing again.Ripe, fragrance, fragrance enter spleen, therefore can returns spleen.Courage can be mended therefore the warm courage of energy.The gas phase of mothers and sons It is logical, therefore also main Virtual is tired, vexatious must not sleep.

On the basis of traditional Chinese medicine is formulated, the social life mode brought along with process of industrialization changes, Yi Jiren Mouth aging society gradually develops, requirement consciousness constantly enhancing, while insomnia and neurasthenia of the people for quality of life Etc. symptoms become increasingly complex, inducement also have more diversity, comply with the great demand present in present society crowd, spina date seed is being protected More stringent requirements are proposed in terms of the exploitation of health food, while also having more vast market prospect.

Invention content

In view of this, in view of the deficiencies of the prior art, it is an object of the present invention to provide a kind of wild jujubes improving sleep quality Benevolence oral solution and preparation method thereof eliminates the puzzlement that multiple types insomnia and neurasthenia are brought.

In order to achieve the above objectives, the present invention uses following technical scheme：

A kind of spina date seed oral solution improving sleep quality, is composed of the following raw materials in parts by weight, spina date seed 100-150 Part, 60-80 parts of gynostemma pentaphylla, 60-80 parts of Radix Notoginseng, 50-70 parts of prepared rehmannia root, 50-70 parts of monkshood, 50-70 parts of barley young leaf powder, macaque 50-70 parts of peach, 50-70 parts of pineapple, 40-50 parts of hawthorn, 40-50 parts of fushen, 40-50 parts of sorghum, 40-50 parts of Radix Codonopsis, honeysuckle 40-50 parts, 40-50 parts of rose, 40-50 parts of cortex albiziae, 30-40 parts of fallen flowers leave, 30-40 parts of the root of Dahurain angelica, 30-40 parts of wrinkled giant hyssop, 10-15 parts of 30-40 parts of lotus leaf, 10-15 parts of valerian, multicolored 10-15 parts of beans, 10-15 parts of honey and Radix Glycyrrhizae；0.5-1 parts of stabilizer, 2-4 parts of flavoring agent.

It is described the five colors beans be etc. weight red bean, soya bean, mung bean, Semen Lablab Album and black soya bean mixture.

The weight ratios such as the stabilizer guar gum and agar mix.

The flavoring agent is the mixture of the weight such as citric acid, ascorbic acid, gluconic acid and xylitol, maltitol..

The present invention also provides a kind of preparation methods for the spina date seed oral solution improving sleep quality.

Include the following steps：

One) processing of Chinese medicine material：

1) Semen Ziziphi Spinosae (parched), crushing, 3-5 times of weight deal petroleum ether refluxing extraction 2-3 times, each 1-2h recycle extracting solution And the dregs of a decoction, the dregs of a decoction are measured 65-75% (v/v) alcohol reflux with 3-5 times and are extracted 3-5 times, each 90min, merge extracting solution, be concentrated into Medicinal extract is scattered in the water of the weight such as medicinal extract, uses ether, ethyl acetate, extracting n-butyl alcohol respectively, merges by medicinal extract, freeze-drying It is spare；1-2 times of ether, ethyl acetate, n-butanol weight are in medicinal extract；

2) wrinkled giant hyssop, the root of Dahurain angelica, rose, honeysuckle, valerian and Radix Glycyrrhizae are cleaned and crush, Ultramicro-powder, with 95% ethyl alcohol 40- 50 DEG C of reduced-pressure backflows extract 30-50 minutes；Phegma and granulated slag are collected respectively, by granulated slag, with 70-80 DEG C of the ethyl alcohol of 45-50% Reduced-pressure backflow extracts 30-50 minutes；Merge extracting solution twice, pH7-7.5 is adjusted with ammonium hydroxide, is stood, is precipitated, filtering removes filter Slag, filtrate freeze-drying are spare；

3) by sorghum, multicolored beans with distilled water immersion, be put into juice extractor crush, squeeze the juice, heat filtering, then cool to 40 DEG C, protease is added, addition is the 0.30-0.40% of juice weight, reacts 3-4 hours, adds juice weight 0.50- 0.60% starch enzyme reaction 3-4 hours, after reaction, juice high temperature destroy the enzyme treatment is spare, the sorghum, multicolored beans are total The solid-liquid ratio of weight and distilled water is 0.03-0.05g/ml；

4) by gynostemma pentaphylla, Radix Notoginseng, fushen, Radix Codonopsis, cortex albiziae, fallen flowers leave, lotus leaf and the root of Dahurain angelica crush, 1.0-2.0 are added Times parts by weight water, 30-50 DEG C is impregnated 1.0-1.5 hours；Then extracting solution and filter residue are collected in ultrasonic extraction, filtering respectively；By institute It is 6-7 to obtain filter residue and adjust pH value, and ethyl alcohol Microwave Extraction is added, collects extracting solution, is lyophilized spare；

Two) Kiwi berry, pineapple and hawthorn are squeezed the juice：The cleaning of Kiwi berry, pineapple and hawthorn, peeling consequence digested tankage is broken, add water It squeezes the juice, filter, pectase, cellulase, protease will be added into juice, it is made to be hydrolyzed at 45-50 DEG C, time 3-5h, The dosage of three kinds of enzymes is respectively that the percentage of pulp weight is：0.02-0.06%, 0.003-0.006%, 0.005- 0.08%；The solid-liquid ratio of pulp and water is 0.01-0.02g/ml；

Three) barley young leaf powder, the young wheat seeding using high-quality organic barley just overwintering length to 25-40cm is tender, freeze-dried, Crushing is prepared；

Four) preparation of oral solution：By step 1), step 2) and step 3) ingredient mixing after be added stabilizer, flavoring agent And honey, it filters, sterilize canned, be prepared into oral solution.

Medicine raw material efficacy effect

Spina date seed, bitter, acid are mild-natured.Converge to heart and liver channels.1, mental-tranquilization, for having a sleepless night, palpitaition.Spina date seed takes a tonic or nourishing food to build up one's health conscience Cloudy blood, antitoxic heart-soothing and sedative effect is stronger, is mental-tranquilization key medicine.It is mainly used for vexed, egersis caused by heart-liver blood deficiency, to having the heart concurrently Throbbing with fear, uneasy, the patient of abnormal sweating is especially suitable.Often with Radix Angelicae Sinensis, Radix Paeoniae Alba, the fleece-flower root, arillus longan with use.If liver void has the dysphoria insomnia of heat, often It is equal with rhizoma anemarrhenae, Poria cocos and uses, such as suanzaoren decoction.If restlessness of asrhenia type and insomnia caused by heart kidney deficiency, hyperactivity of yang due to yin deficiency, palpitaition, forgetful, can with it is profound Ginseng, radix rehmanniae recen, the seed of Oriental arborvitae are equally used, such as Tianwang Buxin Dan.2, arrest sweating promotes the production of body fluid, and is used for body void hidrosis.Spina date seed is sour, there is convergence The work(that hidroschesis promotes the production of body fluid, is usually used in physically weak spontaneous perspiration, night sweat, and the simultaneous person of having no peace of mind is especially suitable.Such as close ginseng, Poria cocos is respectively divided into end, rice Under drink is adjusted, night sweat is controlled.

Gynostemma pentaphylla, bitter, micro-sweet are cool in nature.Return lung, spleen, kidney channel.There are strengthening spleen, tonifying kidney, preventing phlegm from forming and stopping coughing, heat-clearing toxin-expelling functions. Cure mainly physically weak weak, nephrasthenia emission, gastral cavity pain, diarrhea, coughing with a lot of sputum, jaundice, frequent micturition, carcinoma, tinea of feet and hands, underarm odor.

Radix Notoginseng, acrid flavour, sweet, micro-puckery, slight bitter are warm-natured.Return liver, the heart, stomach.There is hemostasis, promoting blood circulation and removing blood stasis, when blood-activating analgetic stops Blood does not stay the stasis of blood, is suitble to go out blood trouble caused by hemostasis.

Prepared rehmannia root, sweet in flavor, slightly warm in nature.Return liver and kidney channel.Nourishing the blood and yin, enriching essence and nourishing marrow.For blood deficiency chlorosis, dizziness palpitaition, Irregular menstruation, hectic fever night sweat are quenched one's thirst, soreness of waist tinnitus.

Monkshood, acrid flavour, sweet, extremely hot in nature.It belongs to the heart, kidney, spleen channel.With deficiency-cold in spleen and stomach is controlled, often it is equal with rhizoma zingiberis, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae With；Insufficiency of both the spleen and the kindey oedema is often equal with Poria cocos, cassia twig, Rhizoma Atractylodis Macrocephalae and uses；Impotence Gong Leng caused by the insufficiency of the kidney yang, it is infertile can with it is ripe Glutinous rehmannia, Chinese cassia tree, Fructus Corni are equally used.2. recuperating depleted yang is with yang depletion syndrome is controlled, often with rhizoma zingiberis, Radix Glycyrrhizae with use；If yang-energy is intended to take off, with Ginseng is the same as use.3. cold-dispelling pain-relieving, with the joint caused pain of wind-cold-dampness arthralgia is controlled, often with cassia twig, Rhizoma Atractylodis Macrocephalae with use；Asthenia cold abdominalgia, often with Rhizoma zingiberis, Rhizoma Atractylodis Macrocephalae, Radix Codonopsis are the same as use；Cold of insufficiency type dysmenorrhoea is often equal with cassia twig, Radix Angelicae Sinensis, fennel seeds and uses.

Barley young leaf powder, sweet-bitter flavor is warm-natured, nontoxic.Enter spleen, lung two passes through.Detumescence, dampness removing, qi-regulating.It is using high-quality organic The young wheat seeding tender leaf of barley just overwintering length to 25-40CM are raw material, are prepared by advanced freeze-drying crushing technology. Product remains the nutrition of the tender seedling of all organic barleys and abundant cellulose.Barley young leaf powder is base-forming food, containing abundant Dietary fiber, vitamin, trace element play an important role to human body cell particularly with hundreds of organized enzyme, be it is big from So vouchsafe us the basic foodstuff of human life and health, green plant life element is a kind of safety and is easy to the reason absorbed Think magical food.

Kiwi berry, it is sour, sweet, cold.Return kidney, stomach, bladder warp.Clearing heat and promoting fluid, each stomach help digestion, and dampness removing is treating stranguria.Suitable for anti- Cancer is stimulated the secretion of milk, anti-inflammatory jaundice, hemorrhoid, alactation.

Pineapple, mild-natured, sweet in flavor, acid.Return kidney, stomach.Tired with solution, invigorating the spleen is quenched one's thirst, clearing damp of subsiding a swelling, the effect of sobering up.Institute It states pineapple and is rich in bromelain,

Hawthorn, it is warm-natured, it is sweet in flavor, sour.Return liver, spleen, stomach.It is promoting blood circulation and removing blood stasis with food digesting stomach fortifying, insect-expelling function.

Fushen, it is sweet in flavor, light, it is mild-natured.The thoughts of returning home, the spleen channel.There is calming heart, calms the nerves, Li Shui.Main palpitation with fear, forgetful, forgetful insomnia are shied Epilepsy, difficult urination.

Sorghum, it is sweet in flavor, puckery, it is warm-natured.Returns spleen, stomach, lung channel.Chinese medicine sorghum has invigorating the spleen to arrest diarrhea, resolving sputum to calm the nerves.Main spleen deficiency is let out It rushes down, cholera, indigestion, productive cough due to phlegm-damp, insomnia and dreamful sleep.

Radix Codonopsis, it is sweet in flavor, it is mild-natured.Distributed in lung channel, the spleen channel.It enriches blood, promotes the production of body fluid, the effect of tonifying spleen lung qi.

Honeysuckle, it is sweet in flavor, it is cold in nature.Return lung, the heart, stomach, large intestine channel.1. clearing heat and detoxicating, with control warm disease it is hot, thirsty from the beginning of, body, Rapid pulse is often equal with Fructus Forsythiae, Radix Isatidis and uses；Sore carbuncle is from the beginning of red and swollen heat pain is often equal with dandelion, wild chrysanthemum, Chinese violet With.2. dispelling wind and heat from the body with affection of exogenous wind-heat exterior syndrome is controlled, is often equal with Fructus Forsythiae, peppermint, Lasiosphaera fenzlii and uses.3. removing heat from the blood and relieve diarrhea with controlling heat toxin blood Dysentery can match purslane, the Chinese bulbul is equally used.

Rose, sweet in flavor, slight bitter, slightly warm in nature.Enter spleen, Liver Channel.There are liver soothing and depression relief, regulating menstruation by adjusting the flow of blood effect.It cures mainly：Chest diaphragm is full It is bored, gastral cavilty, side of body rib, swollen breasts, irregular menstruation, leukorrhea with reddish discharge.Dysentery, traumatic injury, wandering arthritis, carbuncle swells.

Cortex albiziae, it is sweet in flavor, it is mild-natured.Enter the heart, Liver Channel.There are Xie Yu and blood, calming heart, subduing inflammation effect.It cures mainly：Control the mind not Peace, melancholy insomnia, lung carbuncle, carbuncle swells, scrofula, injured bone.

Fallen flowers leave, property slightly sweet flavor are put down.Enter Liver Channel.With clearing heat and detoxicating, the effect of being depressured of allaying excitement.

The root of Dahurain angelica, acrid flavour are warm-natured.It attaches to the lung and stomach meridians.Effect：Expelling wind and clearing away cold, sensible analgesic, detumescence and apocenosis, eliminating dampness stops band.

Wrinkled giant hyssop, acrid flavour, slightly warm in nature.Returns spleen, stomach, lung channel.There are dampness elimination, inducing diaphoresis, preventing or arresting vomiting effect.

Lotus leaf,：It is sour, puckery, temperature.Returns spleen, stomach.Effect：1. clearing away summerheat is with summer disease is controlled, often with flower of hyacinth dolichos, west Melon kingfisher clothing, testa mungo are equally used；Syndrome of summer-heat-dampness is often equal with wrinkled giant hyssop, eupatorium and uses.2. invigorating the spleen rising Yang is with weakness of the spleen and stomach is controlled, often with Rhizoma Atractylodis Macrocephalae, Chinese yam, Radix Astragali, ginseng are equally used.3. cooling blood and hemostasis, with various bleedings caused by blood-head are controlled, often with setose thistle, field thistle, raw cypress Leaf, radix rehmanniae recen are equally used.

Valerian, it is acrid flavour, sweet, it is warm-natured.Converge to heart and liver channels.Calm the nerves, qi-regulating, promoting blood circulation and stopping pain.There are tranquilizing effect, alcohol extracting It takes object that can enhance the sleeping time of barbital, and has apparent expansion coronary artery blood vessel, improve myocardial ischemia, reduce myocardial oxygen consumption, Antiarrhythmic effect；Valerian total alkaloid has antibacterial action；Platyphyllous valerian root volatile oil has significantly isolated intestinal smooth muscle Relaxation and spasmolysis, and have notable regulating blood lipid action.

Multicolored beans, multicolored beans：Red bean bushing is enriched blood；Mung bean tonifying liver, clearing heat and detoxicating, reduction cholesterol；Soya bean tonifying spleen tonifying Qi, Often feeding helps to slow down aging；Black soya bean kidney tonifying；White peas or beans tonifying lung, QI invigorating in reason.

Red bean is also known as rde bean, mild-natured, sweet in flavor, acid.The thoughts of returning home, small intestinl channel.With invigorating spleen for diuresis, removing toxicity for eliminating carbuncles, disappear dampness removing Heat.Rich in the multiple nutritional components such as protein and B family vitamin, red bean has removing toxic substances apocenosis, inducing diuresis for removing edema, clearing heat and removing internal wetness, is good for Spleen antidiarrheal, releases the effect of internal organ are tired at purification blood.

Soya bean, mild-natured, taste：It is sweet, returns spleen, large intestine channel.During invigorating the spleen is wide, the water that disappears, clearing heat and detoxicating, QI invigorating are moisturized.Containing high-quality egg In vain, whole essential amino acids, abundant linoleic acid, phosphatide, phytosterol and vitamin E etc. have very high edible and medicinal Value.《Compendium of Materia Medica》：" soya bean is taken, long skin is made us, beneficial color increases marrow, aerating power, and qi-restoratives can be eaten." visible soya bean The height of value：Blood vessel elasticity, antithrombotic can be increased；It can preventing hypertension, coronary heart disease, artery sclerosis etc.；Phosphorus in soya bean Fat can delay brain cell aging, enhance memory；There are anti-cancer, antitumaous effect；There is effect of promoting longevity.

Semen Lablab Album, Semen Lablab Album is sweet in flavor, tepor, enters lung, stomach, has and middle dampness elimination, tonifying spleen and stopping diarrhea, summer heat clearing toxin resolving and other effects. Suitable for treating taste abnormal heat, vomiting and diarrhea are thirsty fidgety, the diseases such as drunk vomiting.

Mung bean nature and flavor are sweet, tremble with fear, enter the heart, stomach, it is for oral administration have clearing away summerheat, inducing diuresis to remove edema, wet one's whistle quench the thirst, the work(of improving eyesight decompression Effect.Mung bean nutritive value is very high, contains several mineral materials and vitamin.Medical value is also very high.

Black soya bean, nature and flavor are sweet, flat, nontoxic, there is promoting blood circulation, Li Shui, wind-dispelling, clearing heat and detoxicating, the strong blood of nourishing, qi-restoratives black hair work( Effect.Containing abundant protein, fat, vitamin, trace element and crude fibre, bean protein content is up to black soya bean, valence Value is very high.Black soya bean, which contains high-density lipoprotein, can reduce cholesterol level in blood；Black soya bean can supplement lysine not Foot, improves the utilization rate of protein；There is Constipation and enhancing gastrointestinal function to make for cellulose, hemicellulose etc. in black soya bean With；Trypsin inhibitor in black soya bean can inhibit trypsase and chrymotrypsin easy in inactivation；Hemagglutinin in black soya bean, Has the function of red blood cell in solidificating blood；It can be with prevention of arterial hardening, hypertension, diabetes, hypoferric anemia, goitre Greatly；Anti-cancer, antitumaous effect can be played, breast cancer, prostate cancer and colon cancer can be effectively inhibited；Person in middle and old age's sclerotin can be prevented to dredge Pine；It can keep fit and healthy, enhance passive protective physical fitness.

Honey, it is mild-natured；It is sweet in flavor.Return：Spleen, lung, large intestine channel.Bowl spares is moisturized, and is relieved pain, removing toxic substances.

Radix Glycyrrhizae, Radix Glycyrrhizae is sweet in flavor, mild-natured.The thoughts of returning home, spleen, lung, stomach.It invigorates the spleen and benefits qi, moistens the lung and relieve the cough, it is clearing heat and detoxicating, alleviate The effect of analgesic, mitigation pharmacological property.

The beneficial effects of the invention are as follows：

The present invention is uncomfortable in chest with herbal mixture mental-tranquilization, strengthening spleen, tonifying kidney, the alleviation stagnation of the circulation of vital energy, mood agitation, irritability, the diseases such as insomnia Shape.Spina date seed, fushen, wrinkled giant hyssop mental-tranquilization in side, regulating flow of qi, eliminating dampness and eliminating phlegm is for monarch drug in a prescription；Rose, cortex albiziae and sorghum The effect of soothing liver-qi stagnation, invigorating the spleen to arrest diarrhea, resolving sputum are calmed the nerves, and auxiliary monarch drug in a prescription is calmed the nerves；Kiwi berry, multicolored beans, hawthorn and pineapple digestion-promoting Product, scattered stasis keep qi and blood unobstructed, there is Energy benefit taste；Gynostemma pentaphylla, Radix Notoginseng and prepared rehmannia root are nourishing liver and kidney, benefiting shrewd head；It is lotus leaf, big Mai Ruoye powder heat-clearing invigorating the spleen, dampness removing of subsiding a swelling, it is for ministerial drug that can remove eliminating impediment；Fallen flowers leave, the root of Dahurain angelica, the analgesic of honeysuckle eliminating dampness, allay excitement Decompression, dispelling wind and heat from the body, Radix Codonopsis, valerian, monkshood, tonifying Qi are promoted the production of body fluid, and dispelling cold dampness elimination fills blood, and clearing damp gas is for adjutant；Honey, Radix Glycyrrhizae It invigorates the spleen and benefits qi, moistens the lung and relieve the cough, coordinate by medicine, priming channel tropism is to make medicine.

For the present invention through a large amount of experiment and research of inventor, selected source is sufficient, eats with a long history, avirulent medicine food Dual-purpose raw material, characteristic and mutual conspiracy relation of the inventor team according to above-mentioned raw materials, by the warp accumulated all the year round It tests and largely tests and contrast test has obtained proportioning between best raw material, obtain the medicine of dispersing stagnated hepatoqi effect Side；Formula is simplified, and proportioning is reasonable, and suitable for big production, facilitates consumer to take, significant effect.

Meanwhile the present invention also provides unique preparation methods, and the need of the present invention are combined according to the characteristic of each Chinese medicine material It asks, substep classification extraction reaches effective ingredient recovery rate height, and active ingredient is lost in few advantage.Each drug ingedient collocation Rationally, be conducive to the performance of drug effect and the storage of drug.Such as soybean and sorghum are rich in protein and starch, by digesting, incite somebody to action To the advantageous amino acid of body, carbohydrate separate out, convenient for being absorbed and utilized；Other compositions, such as mountain are cooperateed with flavoring agent, honey Short, bristly hair or beard, pineapple and Kiwi berry adjust flavor；Simultaneously by sterilization and it is canned, in conjunction with stabilizer extend period of storage.

Specific implementation mode

Embodiment 1

A kind of spina date seed oral solution improving sleep quality, is composed of the following raw materials in parts by weight, and 100 parts of spina date seed twists 60 parts of stock indigo plant, 60 parts of Radix Notoginseng, 50 parts of prepared rehmannia root, 50 parts of monkshood, 50 parts of barley young leaf powder, 50 parts of Kiwi berry, 50 parts of pineapple, hawthorn 40 parts, 40 parts of fushen, 40 parts of sorghum, 40 parts of Radix Codonopsis, 40 parts of honeysuckle, 40 parts of rose, 40 parts of cortex albiziae, fallen flowers leave 30 10 parts of part, 30 parts of the root of Dahurain angelica, 30 parts of wrinkled giant hyssop, 30 parts of lotus leaf, 10 parts of valerian, multicolored 10 parts of beans, 10 parts of honey and Radix Glycyrrhizae；Stabilizer 0.5 part, 2 parts of flavoring agent.It is described the five colors beans be etc. weight red bean, soya bean, mung bean, Semen Lablab Album and black soya bean mixture；It is described steady Determine the mixing of the weight ratios such as agent guar gum and agar；The flavoring agent be citric acid, ascorbic acid, gluconic acid and xylitol, The mixture of the weight such as maltitol..

Preparation method includes the following steps：

One) processing of Chinese medicine material：

1) Semen Ziziphi Spinosae (parched), crushing, 3 times of weight deal petroleum ether refluxing extractions 2 times, each 1h recycle extracting solution and the dregs of a decoction, The dregs of a decoction are extracted 3 times, each 90min with 3 times of 65% (v/v) alcohol refluxs of amount, are merged extracting solution, are concentrated into medicinal extract, by medicinal extract point It dissipates in the water of the weight such as medicinal extract, uses ether, ethyl acetate, extracting n-butyl alcohol respectively, merge, freeze-drying is spare；The ether, 1 times of ethyl acetate, n-butanol weight are in medicinal extract；

2) wrinkled giant hyssop, the root of Dahurain angelica, rose, honeysuckle, valerian and Radix Glycyrrhizae are cleaned and crush, Ultramicro-powder, with 95% ethyl alcohol 40 DEG C reduced-pressure backflow extracts 30 minutes；Phegma and granulated slag are collected respectively, by granulated slag, with 45% 70 DEG C of reduced-pressure backflow extractions of ethyl alcohol 30 minutes；Merge extracting solution twice, pH7 is adjusted with ammonium hydroxide, is stood, is precipitated, filtering removes filter residue, and filtrate freeze-drying is spare；

3) by sorghum, multicolored beans with distilled water immersion, be put into juice extractor crush, squeeze the juice, heat filtering, then cool to 40 DEG C, protease is added, addition is the 0.30% of juice weight, reacts 3 hours, adds the amylase of juice weight 0.50% Reaction 3 hours, it is after reaction, juice high temperature destroy the enzyme treatment is spare, the sorghum, multicolored beans total weight and distilled water material Liquor ratio is 0.03g/ml；

4) by gynostemma pentaphylla, Radix Notoginseng, fushen, Radix Codonopsis, cortex albiziae, fallen flowers leave, lotus leaf and the root of Dahurain angelica crush, 1.0 times of weights are added Part water is measured, 30 DEG C are impregnated 1.0 hours；Then extracting solution and filter residue are collected in ultrasonic extraction, filtering respectively；Gained filter residue is adjusted PH value is 6, and ethyl alcohol Microwave Extraction is added, and collects extracting solution, and freeze-drying is spare；

Two) Kiwi berry, pineapple and hawthorn are squeezed the juice：The cleaning of Kiwi berry, pineapple and hawthorn, peeling consequence digested tankage is broken, add water It squeezes the juice, filter, pectase, cellulase, protease will be added into juice, it is made to be hydrolyzed at 45 DEG C, time 3h, described three The dosage of kind enzyme is respectively that the percentage of pulp weight is：0.02%, 0.003%, 0.005%；The solid-liquid ratio of pulp and water is 0.01g/ml；

Three) barley young leaf powder, the young wheat seeding using high-quality organic barley just overwintering length to 25cm is tender, freeze-dried, powder It is broken to be prepared；

Embodiment 2

A kind of spina date seed oral solution improving sleep quality, is composed of the following raw materials in parts by weight, and 150 parts of spina date seed twists 80 parts of stock indigo plant, 80 parts of Radix Notoginseng, 70 parts of prepared rehmannia root, 70 parts of monkshood, 70 parts of barley young leaf powder, 70 parts of Kiwi berry, 70 parts of pineapple, hawthorn 50 parts, 50 parts of fushen, 50 parts of sorghum, 50 parts of Radix Codonopsis, 50 parts of honeysuckle, 50 parts of rose, 50 parts of cortex albiziae, fallen flowers leave 40 15 parts of part, 40 parts of the root of Dahurain angelica, 40 parts of wrinkled giant hyssop, 40 parts of lotus leaf, 15 parts of valerian, multicolored 15 parts of beans, 15 parts of honey and Radix Glycyrrhizae；Stabilizer 1 Part, 4 parts of flavoring agent.It is described the five colors beans be etc. weight red bean, soya bean, mung bean, Semen Lablab Album and black soya bean mixture；The stabilizer The weight ratios such as guar gum and agar mix；The flavoring agent is citric acid, ascorbic acid, gluconic acid and xylitol, malt The mixture of the weight such as sugar alcohol..

Preparation method includes the following steps：

One) processing of Chinese medicine material：

1) Semen Ziziphi Spinosae (parched), crushing, 5 times of weight deal petroleum ether refluxing extractions 3 times, each 2h recycle extracting solution and the dregs of a decoction, The dregs of a decoction are extracted 5 times, each 90min with 5 times of 75% (v/v) alcohol refluxs of amount, are merged extracting solution, are concentrated into medicinal extract, by medicinal extract point It dissipates in the water of the weight such as medicinal extract, uses ether, ethyl acetate, extracting n-butyl alcohol respectively, merge, freeze-drying is spare；The ether, 2 times of ethyl acetate, n-butanol weight are in medicinal extract；

2) wrinkled giant hyssop, the root of Dahurain angelica, rose, honeysuckle, valerian and Radix Glycyrrhizae are cleaned and crush, Ultramicro-powder, with 95% ethyl alcohol 50 DEG C reduced-pressure backflow extracts 50 minutes；Phegma and granulated slag are collected respectively, by granulated slag, with 50% 80 DEG C of reduced-pressure backflow extractions of ethyl alcohol 50 minutes；Merge extracting solution twice, pH7.5 is adjusted with ammonium hydroxide, is stood, is precipitated, filtering removes filter residue, and filtrate freeze-drying is spare；

3) by sorghum, multicolored beans with distilled water immersion, be put into juice extractor crush, squeeze the juice, heat filtering, then cool to 40 DEG C, protease is added, addition is the 0.40% of juice weight, reacts 4 hours, adds the amylase of juice weight 0.60% Reaction 4 hours, it is after reaction, juice high temperature destroy the enzyme treatment is spare, the sorghum, multicolored beans total weight and distilled water material Liquor ratio is 0.05g/ml；

4) by gynostemma pentaphylla, Radix Notoginseng, fushen, Radix Codonopsis, cortex albiziae, fallen flowers leave, lotus leaf and the root of Dahurain angelica crush, 2.0 times of weights are added Part water is measured, 50 DEG C are impregnated 1.5 hours；Then extracting solution and filter residue are collected in ultrasonic extraction, filtering respectively；Gained filter residue is adjusted PH value is 7, and ethyl alcohol Microwave Extraction is added, and collects extracting solution, and freeze-drying is spare；

Two) Kiwi berry, pineapple and hawthorn are squeezed the juice：The cleaning of Kiwi berry, pineapple and hawthorn, peeling consequence digested tankage is broken, add water It squeezes the juice, filter, pectase, cellulase, protease will be added into juice, it is made to be hydrolyzed at 50 DEG C, time 5h, described three The dosage of kind enzyme is respectively that the percentage of pulp weight is：0.06%, 0.006%, 0.08%；The solid-liquid ratio of pulp and water is 0.02g/ml；

Three) barley young leaf powder, the young wheat seeding using high-quality organic barley just overwintering length to 40cm is tender, freeze-dried, powder It is broken to be prepared；

Embodiment 3

A kind of spina date seed oral solution improving sleep quality, is composed of the following raw materials in parts by weight, and 125 parts of spina date seed twists 70 parts of stock indigo plant, 70 parts of Radix Notoginseng, 60 parts of prepared rehmannia root, 60 parts of monkshood, 60 parts of barley young leaf powder, 60 parts of Kiwi berry, 60 parts of pineapple, hawthorn 45 parts, 45 parts of fushen, 45 parts of sorghum, 45 parts of Radix Codonopsis, 45 parts of honeysuckle, 45 parts of rose, 45 parts of cortex albiziae, fallen flowers leave 35 13 parts of part, 35 parts of the root of Dahurain angelica, 35 parts of wrinkled giant hyssop, 35 parts of lotus leaf, 15 parts of valerian, multicolored 13 parts of beans, 12 parts of honey and Radix Glycyrrhizae；Stabilizer 0.7 part, 3 parts of flavoring agent.It is described the five colors beans be etc. weight red bean, soya bean, mung bean, Semen Lablab Album and black soya bean mixture；It is described steady Determine the mixing of the weight ratios such as agent guar gum and agar；The flavoring agent be citric acid, ascorbic acid, gluconic acid and xylitol, The mixture of the weight such as maltitol..

Preparation method includes the following steps：

One) processing of Chinese medicine material：

1) Semen Ziziphi Spinosae (parched), crushing, 4 times of weight deal petroleum ether refluxing extractions 2 times, each 1.5h recycle extracting solution and medicine Slag, the dregs of a decoction are extracted 4 times, each 90min with 4 times of 70% (v/v) alcohol refluxs of amount, merge extracting solution, medicinal extract is concentrated into, by medicinal extract It is scattered in the water of the weight such as medicinal extract, uses ether, ethyl acetate, extracting n-butyl alcohol respectively, merge, freeze-drying is spare；The second 1.5 times of ether, ethyl acetate, n-butanol weight are in medicinal extract；

2) wrinkled giant hyssop, the root of Dahurain angelica, rose, honeysuckle, valerian and Radix Glycyrrhizae are cleaned and crush, Ultramicro-powder, with 95% ethyl alcohol 45 DEG C reduced-pressure backflow extracts 40 minutes；Phegma and granulated slag are collected respectively, by granulated slag, with 47% 75 DEG C of reduced-pressure backflow extractions of ethyl alcohol 40 minutes；Merge extracting solution twice, pH7.2 is adjusted with ammonium hydroxide, is stood, is precipitated, filtering removes filter residue, and filtrate freeze-drying is spare；

3) by sorghum, multicolored beans with distilled water immersion, be put into juice extractor crush, squeeze the juice, heat filtering, then cool to 40 DEG C, protease is added, addition is the 0.35% of juice weight, reacts 3.5 hours, adds the starch of juice weight 0.55% Enzyme reaction 3.5 hours, after reaction, juice high temperature destroy the enzyme treatment is spare, the sorghum, multicolored beans total weight and distilled water Solid-liquid ratio be 0.04g/ml；

4) by gynostemma pentaphylla, Radix Notoginseng, fushen, Radix Codonopsis, cortex albiziae, fallen flowers leave, lotus leaf and the root of Dahurain angelica crush, 1.5 times of weights are added Part water is measured, 40 DEG C are impregnated 1.2 hours；Then extracting solution and filter residue are collected in ultrasonic extraction, filtering respectively；Gained filter residue is adjusted PH value is 6.5, and ethyl alcohol Microwave Extraction is added, and collects extracting solution, and freeze-drying is spare；

Two) Kiwi berry, pineapple and hawthorn are squeezed the juice：The cleaning of Kiwi berry, pineapple and hawthorn, peeling consequence digested tankage is broken, add water It squeezes the juice, filter, pectase, cellulase, protease will be added into juice, it is made to be hydrolyzed at 48 DEG C, time 4h, described three The dosage of kind enzyme is respectively that the percentage of pulp weight is：0.04%, 0.0045%, 0.0065%；The solid-liquid ratio of pulp and water For 0.015g/ml；

Three) barley young leaf powder, the young wheat seeding using high-quality organic barley just overwintering length to 35cm is tender, freeze-dried, powder It is broken to be prepared；

Embodiment 4

A kind of spina date seed oral solution improving sleep quality, is composed of the following raw materials in parts by weight, and 110 parts of spina date seed twists 65 parts of stock indigo plant, 65 parts of Radix Notoginseng, 55 parts of prepared rehmannia root, 58 parts of monkshood, 58 parts of barley young leaf powder, 60 parts of Kiwi berry, 55 parts of pineapple, hawthorn 42 parts, 43 parts of fushen, 43 parts of sorghum, 43 parts of Radix Codonopsis, 42 parts of honeysuckle, 41 parts of rose, 44 parts of cortex albiziae, fallen flowers leave 33 11 parts of part, 32 parts of the root of Dahurain angelica, 31 parts of wrinkled giant hyssop, 33 parts of lotus leaf, 11 parts of valerian, multicolored 12 parts of beans, 11 parts of honey and Radix Glycyrrhizae；；Stabilizer 0.6 part, 2.5 parts of flavoring agent.It is described the five colors beans be etc. weight red bean, soya bean, mung bean, Semen Lablab Album and black soya bean mixture；It is described The weight ratios such as stabilizer guar gum and agar mix；The flavoring agent is citric acid, ascorbic acid, gluconic acid and xylose The mixture of the weight such as alcohol, maltitol..

Preparation method includes the following steps：

One) processing of Chinese medicine material：

1) Semen Ziziphi Spinosae (parched), crushing, 3.5 times of weight deal petroleum ether refluxing extractions 3 times, each 2h recycle extracting solution and medicine Slag, the dregs of a decoction are extracted 3 times, each 90min with 3 times of 68% (v/v) alcohol refluxs of amount, merge extracting solution, medicinal extract is concentrated into, by medicinal extract It is scattered in the water of the weight such as medicinal extract, uses ether, ethyl acetate, extracting n-butyl alcohol respectively, merge, freeze-drying is spare；The second 1.3 times of ether, ethyl acetate, n-butanol weight are in medicinal extract；

2) wrinkled giant hyssop, the root of Dahurain angelica, rose, honeysuckle, valerian and Radix Glycyrrhizae are cleaned and crush, Ultramicro-powder, with 95% ethyl alcohol 43 DEG C reduced-pressure backflow extracts 38 minutes；Phegma and granulated slag are collected respectively, by granulated slag, with 48% 73 DEG C of reduced-pressure backflow extractions of ethyl alcohol 38 minutes；Merge extracting solution twice, pH7.1 is adjusted with ammonium hydroxide, is stood, is precipitated, filtering removes filter residue, and filtrate freeze-drying is spare；

3) by sorghum, multicolored beans with distilled water immersion, be put into juice extractor crush, squeeze the juice, heat filtering, then cool to 40 DEG C, protease is added, addition is the 0.32% of juice weight, reacts 3.3 hours, adds the starch of juice weight 0.53% Enzyme reaction 3.3 hours, after reaction, juice high temperature destroy the enzyme treatment is spare, the sorghum, multicolored beans total weight and distilled water Solid-liquid ratio be 0.08g/ml；

4) by gynostemma pentaphylla, Radix Notoginseng, fushen, Radix Codonopsis, cortex albiziae, fallen flowers leave, lotus leaf and the root of Dahurain angelica crush, 1.3 times of weights are added Part water is measured, 35 DEG C are impregnated 1.2 hours；Then extracting solution and filter residue are collected in ultrasonic extraction, filtering respectively；Gained filter residue is adjusted PH value is 6.2, and ethyl alcohol Microwave Extraction is added, and collects extracting solution, and freeze-drying is spare；

Two) Kiwi berry, pineapple and hawthorn are squeezed the juice：The cleaning of Kiwi berry, pineapple and hawthorn, peeling consequence digested tankage is broken, add water It squeezes the juice, filter, pectase, cellulase, protease will be added into juice, it is made to be hydrolyzed at 46 DEG C, time 3.6h is described The dosage of three kinds of enzymes is respectively that the percentage of pulp weight is：0.03%, 0.004%, 0.006%；The solid-liquid ratio of pulp and water For 0.013g/ml；

Embodiment 5

A kind of spina date seed oral solution improving sleep quality, is composed of the following raw materials in parts by weight, and 140 parts of spina date seed twists 75 parts of stock indigo plant, 76 parts of Radix Notoginseng, 65 parts of prepared rehmannia root, 68 parts of monkshood, 66 parts of barley young leaf powder, 67 parts of Kiwi berry, 65 parts of pineapple, hawthorn 48 parts, 48 parts of fushen, 47 parts of sorghum, 48 parts of Radix Codonopsis, 49 parts of honeysuckle, 46 parts of rose, 48 parts of cortex albiziae, fallen flowers leave 38 14 parts of part, 39 parts of the root of Dahurain angelica, 37 parts of wrinkled giant hyssop, 38 parts of lotus leaf, 14 parts of valerian, multicolored 14 parts of beans, 13 parts of honey and Radix Glycyrrhizae；Stabilizer 0.7 part, 2.8 parts of flavoring agent.It is described the five colors beans be etc. weight red bean, soya bean, mung bean, Semen Lablab Album and black soya bean mixture；It is described The weight ratios such as stabilizer guar gum and agar mix；The flavoring agent is citric acid, ascorbic acid, gluconic acid and xylose The mixture of the weight such as alcohol, maltitol..

Preparation method includes the following steps：

One) processing of Chinese medicine material：

1) Semen Ziziphi Spinosae (parched), crushing, 4.5 times of weight deal petroleum ether refluxing extractions 3 times, each 2h recycle extracting solution and medicine Slag, the dregs of a decoction are extracted 4 times, each 90min with 3 times of 69% (v/v) alcohol refluxs of amount, merge extracting solution, medicinal extract is concentrated into, by medicinal extract It is scattered in the water of the weight such as medicinal extract, uses ether, ethyl acetate, extracting n-butyl alcohol respectively, merge, freeze-drying is spare；The second 1.4 times of ether, ethyl acetate, n-butanol weight are in medicinal extract；

2) wrinkled giant hyssop, the root of Dahurain angelica, rose, honeysuckle, valerian and Radix Glycyrrhizae are cleaned and crush, Ultramicro-powder, with 95% ethyl alcohol 47 DEG C reduced-pressure backflow extracts 45 minutes；Phegma and granulated slag are collected respectively, by granulated slag, with 49% 78 DEG C of reduced-pressure backflow extractions of ethyl alcohol 48 minutes；Merge extracting solution twice, pH7.4 is adjusted with ammonium hydroxide, is stood, is precipitated, filtering removes filter residue, and filtrate freeze-drying is spare；

3) by sorghum, multicolored beans with distilled water immersion, be put into juice extractor crush, squeeze the juice, heat filtering, then cool to 40 DEG C, protease is added, addition is the 0.36% of juice weight, reacts 3.6 hours, adds the starch of juice weight 0.53% Enzyme reaction 3.3 hours, after reaction, juice high temperature destroy the enzyme treatment is spare, the sorghum, multicolored beans total weight and distilled water Solid-liquid ratio be 0.039g/ml；

4) by gynostemma pentaphylla, Radix Notoginseng, fushen, Radix Codonopsis, cortex albiziae, fallen flowers leave, lotus leaf and the root of Dahurain angelica crush, 1.6 times of weights are added Part water is measured, 34 DEG C are impregnated 1.1 hours；Then extracting solution and filter residue are collected in ultrasonic extraction, filtering respectively；Gained filter residue is adjusted PH value is 6.3, and ethyl alcohol Microwave Extraction is added, and collects extracting solution, and freeze-drying is spare；

Two) Kiwi berry, pineapple and hawthorn are squeezed the juice：The cleaning of Kiwi berry, pineapple and hawthorn, peeling consequence digested tankage is broken, add water It squeezes the juice, filter, pectase, cellulase, protease will be added into juice, it is made to be hydrolyzed at 46 DEG C, time 3.8h is described The dosage of three kinds of enzymes is respectively that the percentage of pulp weight is：0.03%, 0.005%, 0.007%；The solid-liquid ratio of pulp and water For 0.018g/ml；

Three) barley young leaf powder, the young wheat seeding using high-quality organic barley just overwintering length to 29cm is tender, freeze-dried, powder It is broken to be prepared；

Embodiment 6

A kind of spina date seed oral solution improving sleep quality, is composed of the following raw materials in parts by weight, and 120 parts of spina date seed twists 78 parts of stock indigo plant, 68 parts of Radix Notoginseng, 58 parts of prepared rehmannia root, 66 parts of monkshood, 68 parts of barley young leaf powder, 65 parts of Kiwi berry, 59 parts of pineapple, hawthorn 47 parts, 44 parts of fushen, 49 parts of sorghum, 47 parts of Radix Codonopsis, 46 parts of honeysuckle, 48 parts of rose, 49 parts of cortex albiziae, fallen flowers leave 33 13 parts of part, 39 parts of the root of Dahurain angelica, 36 parts of wrinkled giant hyssop, 39 parts of lotus leaf, 13 parts of valerian, multicolored 13 parts of beans, 14 parts of honey and Radix Glycyrrhizae；Stabilizer 0.9 part, 3.5 parts of flavoring agent.It is described the five colors beans be etc. weight red bean, soya bean, mung bean, Semen Lablab Album and black soya bean mixture；It is described The weight ratios such as stabilizer guar gum and agar mix；The flavoring agent is citric acid, ascorbic acid, gluconic acid and xylose The mixture of the weight such as alcohol, maltitol..

Preparation method includes the following steps：

One) processing of Chinese medicine material：

1) Semen Ziziphi Spinosae (parched), crushing, 3 times of weight deal petroleum ether refluxing extractions 3 times, each 1.8h recycle extracting solution and medicine Slag, the dregs of a decoction are extracted 3 times, each 90min with 4.5 times of 72% (v/v) alcohol refluxs of amount, merge extracting solution, be concentrated into medicinal extract, will soak Cream is scattered in the water of the weight such as medicinal extract, uses ether, ethyl acetate, extracting n-butyl alcohol respectively, is merged, and freeze-drying is spare；It is described 1.8 times of ether, ethyl acetate, n-butanol weight are in medicinal extract；

2) wrinkled giant hyssop, the root of Dahurain angelica, rose, honeysuckle, valerian and Radix Glycyrrhizae are cleaned and crush, Ultramicro-powder, with 95% ethyl alcohol 48 DEG C reduced-pressure backflow extracts 48 minutes；Phegma and granulated slag are collected respectively, by granulated slag, with 47% 77 DEG C of reduced-pressure backflow extractions of ethyl alcohol 47 minutes；Merge extracting solution twice, pH7.3 is adjusted with ammonium hydroxide, is stood, is precipitated, filtering removes filter residue, and filtrate freeze-drying is spare；

3) by sorghum, multicolored beans with distilled water immersion, be put into juice extractor crush, squeeze the juice, heat filtering, then cool to 40 DEG C, protease is added, addition is the 0.37% of juice weight, reacts 3.7 hours, adds the starch of juice weight 0.59% Enzyme reaction 3.9 hours, after reaction, juice high temperature destroy the enzyme treatment is spare, the sorghum, multicolored beans total weight and distilled water Solid-liquid ratio be 0.044g/ml；

4) by gynostemma pentaphylla, Radix Notoginseng, fushen, Radix Codonopsis, cortex albiziae, fallen flowers leave, lotus leaf and the root of Dahurain angelica crush, 1.4 times of weights are added Part water is measured, 42 DEG C are impregnated 1.4 hours；Then extracting solution and filter residue are collected in ultrasonic extraction, filtering respectively；Gained filter residue is adjusted PH value is 6.6, and ethyl alcohol Microwave Extraction is added, and collects extracting solution, and freeze-drying is spare；

Two) Kiwi berry, pineapple and hawthorn are squeezed the juice：The cleaning of Kiwi berry, pineapple and hawthorn, peeling consequence digested tankage is broken, add water It squeezes the juice, filter, pectase, cellulase, protease will be added into juice, it is made to be hydrolyzed at 49 DEG C, time 4.8h is described The dosage of three kinds of enzymes is respectively that the percentage of pulp weight is：0.052%, 0.0055%, 0.0075%；The feed liquid of pulp and water Than for 0.019g/ml；

Three) barley young leaf powder, the young wheat seeding using high-quality organic barley just overwintering length to 33cm is tender, freeze-dried, powder It is broken to be prepared；

Comparative example 1

Comparative example 1 is substantially the same manner as Example 3, the difference is that, dispel multicolored beans.

Comparative example 2

Comparative example 2 is substantially the same manner as Example 3, the difference is that, dispel barley young leaf powder.

Comparative example 3

Comparative example 3 is substantially the same manner as Example 3, the difference is that, by spina date seed with etc. the Flos Albiziaes of parts by weight replace Generation.

Flos Albiziae is sweet in flavor, bitter, mild-natured.The thoughts of returning home, liver, the spleen channel.Chinese medicine Flos Albiziae has tranquilizing the mind to solve strongly fragrant, regulating qi-flowing for harmonizing stomach, clears liver bright Purpose effect.It cures mainly：Melancholy insomnia, deficiency of food uncomfortable in chest, wind fire mesh disease, blurring of vision.Clinical drug effect：

The influence of Oral Liquid On Mice autonomic activities of the present invention

1, experimental setup

Healthy Kunming mouse 140 is taken, 14 groups is randomly divided by weight equilibrium, every group 10, it is big to be divided into embodiment 1-3 Dosage group：100 crude drug mg/kg, gavage；Embodiment 1-3 small dose groups：50 crude drug mg/kg, gavage；Diazepam group：5mg/kg, Gavage；Blank group：Distilled water 10ml/kg, gastric infusion.The large dosage of group of comparative example 1：100 crude drug mg/kg, gavage；Comparative example 1 Small dose group：50 crude drug mg/kg, gavage；The large dosage of group of comparative example 2：100 crude drug mg/kg, gavage；2 small dose group of comparative example： 50 crude drug mg/kg, gavage；The large dosage of group of comparative example 3：100 crude drug mg/kg, gavage；3 small dose group of comparative example：50 crude drug mg/ Kg, gavage；Once a day, continuous three days.

2, experimental method and result：According to Xu Shuyun edit " pharmacological experimental methodology " (third edition), using photoelectric method into Row.

Grouping test, 60min is tested after administration：

Mouse sets and adapts to 3min in active box, and the mouse autonomic activities number then surveyed in 10min simultaneously records.Every group in three times Administration, dosing interval 10min, until by three groups of mouse administrations and being completed.Using SPss10.1 statistical softwares, Dan Yin is used LSD inspections carry out carry out statistical disposition between plain variance analysis combination group.

Compared with blank group, embodiment 1,2,3 (large and small dosage group) and diazepam group can be such that mouse autonomic activities subtract Few (P ＜ 0.05 or 0.01)；Compared with embodiment 1,2,3 (large and small dosage group), diazepam group is weaker than the sedation of mouse Embodiment (large and small dosage group).Embodiment 1,2,3 groups produce more good sedation.

Influence of each group to mouse autonomic activities

Compared with blank group, * * P ＜ 0.01, * P ＜ 0.05

Model case

Patient Mr. Ji, female, 49 years old, manager；

Main suit：Insomnia more than 1 month aggravates 1 week；Present illness history：Patient before 1 month because there is insomnia in house hold affairs, And increasingly aggravate, difficulty falling asleep, early awakening, early morning get up after cannot restore abundant energy, thinking ability is not clear enough, daytime be easy Dizzy, tired, inability, drowsiness.Above-mentioned symptom is more serious before 1 week, cannot fall asleep whole night sometimes, and tight with throat and chest Contract sense, headache, physical distress and gastrointestinal symptoms.Chinese medical discrimination：Patient is usually when anything crops up easily vexed, touches thing and easily shies, belongs to heart and gallbladder more The deficiency of vital energy；In addition irritability is retarded by silt, and with the passing of time injures qi and blood and insufficiency of vital energy and blood, the heart is caused to become homeless foster, have ants in one's pants and have a sleepless night, dreaminess.It examines to lose Dormancy disease is fully recovered after taking one course for the treatment of of oral solution of the present invention.

Patient Lee, man 55 years old, have a sleepless night more than ten years, first visit of coming in one month, slightly worry then all night egersis, even if It falls asleep also early awakening, daytime, lassitude, felt dizzy, and had palpitation.It examines as chronic insomnia, after taking three courses for the treatment of of oral solution of the present invention Recovery from illness.

Patient Zhang, man, 40 years old, advertising work, general manager had a sleepless night nearly one month, it is invalid to take hypnotic.Patient's look Tired out, complexion is dark yellow, with streaks of white hair, and appetite is bad, and constipation becomes normality, and weight declines unconsciously., do not like with people link up and Exchange or even gratuitous detest other people.Chinese medicine thinks patient's blood deficiency blood not nourishing heart, therefore insomnia and dreamful sleep；High liver fire is then Irritability blurred vision is diagnosed as insomnia, depression.It fully recovers after taking three courses for the treatment of of medicine oral solution of the present invention.

In addition, the present invention randomly chooses insomniac 100, fully recovers 94 after a course of therapy, account for 94%；It is good Turn 5, accounts for 5%；Invalid 1, account for 1%；Total effective rate 99%.Without any side effects to patient shown in treatment, three is big normal Rule chemical examination and hepatic and renal function detect no abnormal phenomenon.

Finally illustrate, the above examples are only used to illustrate the technical scheme of the present invention and are not limiting, this field is common Other modifications or equivalent replacement that technical staff makes technical scheme of the present invention, without departing from technical solution of the present invention Spirit and scope, be intended to be within the scope of the claims of the invention.

Claims

1. a kind of spina date seed oral solution improving sleep quality, which is characterized in that be composed of the following raw materials in parts by weight, spina date seed 100-150 parts, 60-80 parts of gynostemma pentaphylla, 60-80 parts of Radix Notoginseng, 50-70 parts of prepared rehmannia root, 50-70 parts of monkshood, barley young leaf powder 50-70 Part, 50-70 parts of Kiwi berry, 50-70 parts of pineapple, 40-50 parts of hawthorn, 40-50 parts of fushen, 40-50 parts of sorghum, 40-50 parts of Radix Codonopsis, 40-50 parts of honeysuckle, 40-50 parts of rose, 40-50 parts of cortex albiziae, 30-40 parts of fallen flowers leave, 30-40 parts of the root of Dahurain angelica, wrinkled giant hyssop 30- 10-15 parts of 40 parts, 30-40 parts of lotus leaf, 10-15 parts of valerian, multicolored 10-15 parts of beans, 10-15 parts of honey and Radix Glycyrrhizae；Stabilizer 0.5-1 parts, 2-4 parts of flavoring agent；The weight ratios such as the stabilizer guar gum and agar mix；The flavoring agent be citric acid, The mixture of the weight such as ascorbic acid, gluconic acid and xylitol, maltitol.

2. the spina date seed oral solution according to claim 1 for improving sleep quality, which is characterized in that by following parts by weight Raw material form, 100 parts of spina date seed, 60 parts of gynostemma pentaphylla, 60 parts of Radix Notoginseng, 50 parts of prepared rehmannia root, 50 parts of monkshood, 50 parts of barley young leaf powder, 50 parts of Kiwi berry, 50 parts of pineapple, 40 parts of hawthorn, 40 parts of fushen, 40 parts of sorghum, 40 parts of Radix Codonopsis, 40 parts of honeysuckle, rose 40 Part, 40 parts of cortex albiziae, 30 parts of fallen flowers leave, 30 parts of the root of Dahurain angelica, 30 parts of wrinkled giant hyssop, 30 parts of lotus leaf, 10 parts of valerian, multicolored 10 parts of beans, bee 10 parts of 10 parts of honey and Radix Glycyrrhizae；0.5 part of stabilizer, 2 parts of flavoring agent.

3. the spina date seed oral solution according to claim 1 for improving sleep quality, which is characterized in that by following parts by weight Raw material form, 150 parts of spina date seed, 80 parts of gynostemma pentaphylla, 80 parts of Radix Notoginseng, 70 parts of prepared rehmannia root, 70 parts of monkshood, 70 parts of barley young leaf powder, 70 parts of Kiwi berry, 70 parts of pineapple, 50 parts of hawthorn, 50 parts of fushen, 50 parts of sorghum, 50 parts of Radix Codonopsis, 50 parts of honeysuckle, rose 50 Part, 50 parts of cortex albiziae, 40 parts of fallen flowers leave, 40 parts of the root of Dahurain angelica, 40 parts of wrinkled giant hyssop, 40 parts of lotus leaf, 15 parts of valerian, multicolored 15 parts of beans, bee 15 parts of 15 parts of honey and Radix Glycyrrhizae；1 part of stabilizer, 4 parts of flavoring agent.

4. the spina date seed oral solution according to claim 1 for improving sleep quality, which is characterized in that by following parts by weight Raw material form, 125 parts of spina date seed, 70 parts of gynostemma pentaphylla, 70 parts of Radix Notoginseng, 60 parts of prepared rehmannia root, 60 parts of monkshood, 60 parts of barley young leaf powder, 60 parts of Kiwi berry, 60 parts of pineapple, 45 parts of hawthorn, 45 parts of fushen, 45 parts of sorghum, 45 parts of Radix Codonopsis, 45 parts of honeysuckle, rose 45 Part, 45 parts of cortex albiziae, 35 parts of fallen flowers leave, 35 parts of the root of Dahurain angelica, 35 parts of wrinkled giant hyssop, 35 parts of lotus leaf, 15 parts of valerian, multicolored 13 parts of beans, bee 13 parts of 12 parts of honey and Radix Glycyrrhizae；0.7 part of stabilizer, 3 parts of flavoring agent.

5. a kind of preparation method of any one of claim 1-4 spina date seed oral solutions for improving sleep quality, feature exist In including the following steps：

One）The processing of Chinese medicine material：

1）Semen Ziziphi Spinosae (parched), crushing, 3-5 times of weight deal petroleum ether refluxing extraction 2-3 times, each 1-2 h, recycling extracting solution and The dregs of a decoction, the dregs of a decoction are extracted 3-5 times, each 90min with the 3-5 times of alcohol reflux for measuring volume fraction 65-75%, merge extracting solution, dense It is reduced to medicinal extract, medicinal extract is scattered in the water of the weight such as medicinal extract, uses ether, ethyl acetate, extracting n-butyl alcohol respectively, is merged, It is lyophilized spare；1-2 times of ether, ethyl acetate, n-butanol weight are in medicinal extract；

2）Wrinkled giant hyssop, the root of Dahurain angelica, rose, honeysuckle, valerian and Radix Glycyrrhizae are cleaned and crush, Ultramicro-powder, with 95% 40-50 DEG C of ethyl alcohol Reduced-pressure backflow extracts 30-50 minutes；It collects phegma respectively and granulated slag depressurizes back granulated slag with 70-80 DEG C of the ethyl alcohol of 45-50% Stream extraction 30-50 minutes；Merge extracting solution twice, pH7-7.5 is adjusted with ammonium hydroxide, is stood, is precipitated, filtering removes filter residue, filtrate It is lyophilized spare；

3）By sorghum, multicolored beans with distilled water immersion, be put into juice extractor crush, squeeze the juice, heat filtering, then cool to 40 DEG C, It is after enzymolysis, enzymolysis, juice high temperature destroy the enzyme treatment is spare；

4）By gynostemma pentaphylla, Radix Notoginseng, fushen, Radix Codonopsis, cortex albiziae, fallen flowers leave, lotus leaf and the root of Dahurain angelica crush, 1.0-2.0 times of addition weighs Part water is measured, 30-50 DEG C is impregnated 1.0-1.5 hours；Then extracting solution and filter residue are collected in ultrasonic extraction, filtering respectively；Gained is filtered It is 6-7 that slag, which adjusts pH value, and ethyl alcohol Microwave Extraction is added, and collects extracting solution, and freeze-drying is spare；

Two）Kiwi berry, pineapple and hawthorn are squeezed the juice：The cleaning of Kiwi berry, pineapple and hawthorn, peeling consequence digested tankage is broken, water is added to squeeze the juice, Filtering, will be spare after juice by enzymolysis；

Three）Barley young leaf powder, the young wheat seeding using high-quality organic barley just overwintering length to 25-40cm is tender, freeze-dried, crush It is prepared；

Four）The preparation of oral solution：By step 1）, step 2）And step 3）Stabilizer, flavoring agent and bee is added after ingredient mixing Honey filters, sterilizes canned, is prepared into oral solution.

6. preparation method according to claim 5, which is characterized in that step 3）Enzymolysis step specifically, be added albumen Enzyme, addition are the 0.30-0.40% of juice weight, react 3-4 hours, add the amylase of juice weight 0.50-0.60% Reaction 3-4 hours.

7. preparation method according to claim 5, which is characterized in that step 3）The sorghum, multicolored beans total weight and steaming The solid-liquid ratio of distilled water is 0.03-0.05g/ml.

8. preparation method according to claim 5, which is characterized in that step 2）The enzymolysis the specific steps are to juice Enzyme pectase, cellulase, protease are added in liquid, it is made to be hydrolyzed at 45-50 DEG C, time 3-5h, the use of three kinds of enzymes Amount is respectively that the percentage of pulp weight is：0.02-0.06%、0.003-0.006%、0.005-0.08%；The feed liquid of pulp and water Than for 0.01-0.02g/ml.

9. preparation method according to claim 5, which is characterized in that step 2）The solid-liquid ratio of the pulp and water is 0.01-0.02g/ml。