CN108498438A - A kind of antiallergic composition and its preparation method and application - Google Patents
A kind of antiallergic composition and its preparation method and application Download PDFInfo
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- CN108498438A CN108498438A CN201810578038.5A CN201810578038A CN108498438A CN 108498438 A CN108498438 A CN 108498438A CN 201810578038 A CN201810578038 A CN 201810578038A CN 108498438 A CN108498438 A CN 108498438A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
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Abstract
The invention discloses a kind of antiallergic compositions and its preparation method and application.The antiallergic composition includes the raw material of following parts by weight:25 38 parts of long sunglo, 14 22 parts of dust-brand reindeer moss avenge 39 parts of tea, 25 parts of diatomite, 5 10 parts of sea cucumber intestine, 40 80 parts of deionized water.The antiallergic composition of the present invention is compounded by long sunglo, dust-brand reindeer moss, snow tea, diatomite, sea cucumber intestine and deionized water, produces unexpected synergistic effect, can preferably be applied to treatment skin allergy;Raw material is few, and preparation method is simple, is conducive to manufacture.
Description
Technical field
The present invention relates to cosmetic technical field, specifically a kind of antiallergic composition and its preparation method and application.
Background technology
In recent years, with the variation of dietary structure, atmosphere pollution, the increase of live and work pressure, autopath is drastically
Increase.Especially in developed countries such as Japan, the U.S., skin sensitivity has become the social concern for influencing human health.According to
Incomplete statistics, the crowd that the whole world feels sensibility skin is more and more, and wherein male accounts for 38%, and women accounts for 61%.Cause
This has effects that the cosmetics of antiallergic anti-irritant are increasingly subject to the attention of people, has the active substance of antiallergic anti-irritant, especially
It is that botanical components are favored by scholar and market.With modern experimental means research Chinese traditional herbs, it will help excavate
Efficiently, less toxic, low side effect antiallergy product.
Common cutaneous anaphylaxis is referred to as hypersensitivity, also known as allergy in medicine, refers to that body is resisted by certain
When primary stimuli, there is the abnormal specific immune response based on physiological dysfunction or tissue cell insult.It takes
Certainly in two factors:The stimulation of antigen and the reactivity of body.Allergic constitution is usually that will be easy to happen allergic reaction and allergy
Property disease and the people that can not find pathogenic factor, referred to as " allergic constitution ".It induces anaphylactoid antigen and is known as anaphylactogen.Draw
Playing anaphylactoid antigenic substance has hundreds of kinds, they make body sensitization by the modes such as sucking, eating, inject or contact.
Relevant explanation according to traditional Chinese and western medicine and biology to skin allergy, with reference to the principle of Chinese medicine " integrated control ", makeup
Product prevent skin sensitivity and the common approach of stimulation is:1. far from anaphylactogen, sensibiligen autostimulation is reduced;2. inhibiting histamine
Etc. inflammatory mediator releases;3. enhancing body barrier function;The above controlling way, any one blocking can all obtain certain anti-
Effect is controlled, but to reach good antiallergic effect, it should use for reference and using " whole prevention " idea of Chinese medicine, comprehensively and form net
The prevention of network shape can be only achieved excellent antiallergic effect.
Invention content
The purpose of the present invention is to provide a kind of antiallergic compositions and its preparation method and application, to solve above-mentioned background skill
The problem of being proposed in art.
To achieve the above object, the present invention provides the following technical solutions:
A kind of antiallergic composition, the antiallergic composition include the raw material of following parts by weight:It is sunglo 25-38 parts long,
14-22 parts of dust-brand reindeer moss avenges 3-9 parts of tea, 2-5 parts of diatomite, 5-10 parts of sea cucumber intestine, 40-80 parts of deionized water.
As a further solution of the present invention:The antiallergic composition includes the raw material of following parts by weight:Long sunglo
29-36 parts, 17-20 parts of dust-brand reindeer moss avenges 5-8 parts of tea, 3-4 parts of diatomite, 6-9 parts of sea cucumber intestine, 47-70 parts of deionized water.
As a further solution of the present invention:The antiallergic composition includes the raw material of following parts by weight:Long sunglo
33.2 parts, 18.7 parts of dust-brand reindeer moss avenges 6.1 parts of tea, 3.5 parts of diatomite, 8.2 parts of sea cucumber intestine, 52.6 parts of deionized water.
A kind of preparation method of antiallergic composition, includes the following steps:(1) by long sunglo, dust-brand reindeer moss and snow tea difference
Then long sunglo powder, dust-brand litmus powder and snow tea powder are uniformly mixed by drying, the 400-800 mesh that pulverizes and sieves after cleaning, addition is gone
It is uniformly mixed in ionized water, is placed at 130-145 DEG C and steams 1-2h, filtered, obtain mixed liquor one and filter residue;(2) by sea cucumber intestine with
Mixed liquor one mixes, and is placed under room temperature and stirs evenly, obtains mixed liquor two;(3) diatomite is pulverized and sieved into 700-900 mesh, with
It after mixed liquor two infiltrates, is placed at 140-158 DEG C and steams 1-2h, take out, it is dry;(4) after filter residue being dried with upper step gains
Be uniformly mixed, be placed at 100-120 DEG C and steam 5-10h, take out, it is dry to get.
As a further solution of the present invention:Step (1) is dry after cleaning long sunglo, dust-brand reindeer moss and snow tea respectively,
Pulverize and sieve 600 mesh, be then uniformly mixed long sunglo powder, dust-brand litmus powder and snow tea powder, be added in deionized water mix it is equal
It is even, it is placed at 135 DEG C and steams 1.3h, filter, obtain mixed liquor one and filter residue.
As a further solution of the present invention:Diatomite is pulverized and sieved 800 mesh by step (3), after being infiltrated with mixed liquor two,
It is placed at 148 DEG C and steams 1.6h, take out, it is dry.
As a further solution of the present invention:Step (4) is uniformly mixed after drying filter residue with upper step gains, is placed in
Steam 7h at 110 DEG C, take out, it is dry to get.
A kind of application of antiallergic composition in the cosmetics for preparing treatment skin allergy.
Compared with prior art, the beneficial effects of the invention are as follows:
The antiallergic composition of the present invention is multiple by long sunglo, dust-brand reindeer moss, snow tea, diatomite, sea cucumber intestine and deionized water
With into, produce unexpected synergistic effect, can preferably be applied to treatment skin allergy;The antiallergic composition of the present invention
Raw material is few, and preparation method is simple, is conducive to manufacture.
Specific implementation mode
The technical solution of this patent is described in more detail With reference to embodiment.
Embodiment 1
A kind of antiallergic composition, the antiallergic composition include the raw material of following parts by weight:25 parts of long sunglo, dust-brand
14 parts of reindeer moss avenges 3 parts of tea, 2 parts of diatomite, 5 parts of sea cucumber intestine, 40 parts of deionized water.
A kind of preparation method of antiallergic composition, includes the following steps:(1) by long sunglo, dust-brand reindeer moss and snow tea difference
Then long sunglo powder, dust-brand litmus powder and snow tea powder are uniformly mixed, deionization are added by drying, 400 mesh that pulverize and sieve after cleaning
It is uniformly mixed in water, is placed at 130 DEG C and steams 1h, filtered, obtain mixed liquor one and filter residue;(2) sea cucumber intestine and mixed liquor one are mixed
It closes, is placed under room temperature and stirs evenly, obtain mixed liquor two;(3) diatomite is pulverized and sieved into 700 mesh, after being infiltrated with mixed liquor two,
It is placed at 140 DEG C and steams 1h, take out, it is dry;(4) it is uniformly mixed with upper step gains after drying filter residue, is placed at 100 DEG C and steams
5h processed takes out, it is dry to get.
Embodiment 2
A kind of antiallergic composition, the antiallergic composition include the raw material of following parts by weight:38 parts of long sunglo, dust-brand
22 parts of reindeer moss avenges 9 parts of tea, 5 parts of diatomite, 10 parts of sea cucumber intestine, 80 parts of deionized water.
A kind of preparation method of antiallergic composition, includes the following steps:(1) by long sunglo, dust-brand reindeer moss and snow tea difference
Then long sunglo powder, dust-brand litmus powder and snow tea powder are uniformly mixed, deionization are added by drying, 800 mesh that pulverize and sieve after cleaning
It is uniformly mixed in water, is placed at 145 DEG C and steams 2h, filtered, obtain mixed liquor one and filter residue;(2) sea cucumber intestine and mixed liquor one are mixed
It closes, is placed under room temperature and stirs evenly, obtain mixed liquor two;(3) diatomite is pulverized and sieved into 900 mesh, after being infiltrated with mixed liquor two,
It is placed at 158 DEG C and steams 2h, take out, it is dry;(4) it is uniformly mixed with upper step gains after drying filter residue, is placed at 120 DEG C and steams
10h processed takes out, it is dry to get.
Embodiment 3
A kind of antiallergic composition, the antiallergic composition include the raw material of following parts by weight:33.2 parts of long sunglo is black
18.7 parts of fringe reindeer moss avenges 6.1 parts of tea, 3.5 parts of diatomite, 8.2 parts of sea cucumber intestine, 52.6 parts of deionized water.
A kind of preparation method of antiallergic composition, includes the following steps:(1) by long sunglo, dust-brand reindeer moss and snow tea difference
Then long sunglo powder, dust-brand litmus powder and snow tea powder are uniformly mixed, deionization are added by drying, 600 mesh that pulverize and sieve after cleaning
It is uniformly mixed in water, is placed at 135 DEG C and steams 1.3h, filtered, obtain mixed liquor one and filter residue.(2) by sea cucumber intestine and mixed liquor one
Mixing, is placed under room temperature and stirs evenly, obtain mixed liquor two;(3) diatomite is pulverized and sieved into 800 mesh, is infiltrated with mixed liquor two
Afterwards, it is placed at 148 DEG C and steams 1.6h, take out, it is dry.(4) it is uniformly mixed with upper step gains after drying filter residue, is placed in 110
Steam 7h at DEG C, take out, it is dry to get.
Embodiment 4
A kind of antiallergic composition, the antiallergic composition include the raw material of following parts by weight:29 parts of long sunglo, dust-brand
17 parts of reindeer moss avenges 5 parts of tea, 3 parts of diatomite, 6 parts of sea cucumber intestine, 47 parts of deionized water.
A kind of preparation method of antiallergic composition, includes the following steps:(1) by long sunglo, dust-brand reindeer moss and snow tea difference
Then long sunglo powder, dust-brand litmus powder and snow tea powder are uniformly mixed, deionization are added by drying, 500 mesh that pulverize and sieve after cleaning
It is uniformly mixed in water, is placed at 140 DEG C and steams 1.1h, filtered, obtain mixed liquor one and filter residue;(2) by sea cucumber intestine and mixed liquor one
Mixing, is placed under room temperature and stirs evenly, obtain mixed liquor two;(3) diatomite is pulverized and sieved into 750 mesh, is infiltrated with mixed liquor two
Afterwards, it is placed at 145 DEG C and steams 1.3h, take out, it is dry;(4) it is uniformly mixed with upper step gains after drying filter residue, is placed in 105
Steam 6h at DEG C, take out, it is dry to get.
Embodiment 5
A kind of antiallergic composition, the antiallergic composition include the raw material of following parts by weight:36 parts of long sunglo, dust-brand
20 parts of reindeer moss avenges 8 parts of tea, 4 parts of diatomite, 9 parts of sea cucumber intestine, 70 parts of deionized water.
A kind of preparation method of antiallergic composition, includes the following steps:(1) by long sunglo, dust-brand reindeer moss and snow tea difference
Then long sunglo powder, dust-brand litmus powder and snow tea powder are uniformly mixed, deionization are added by drying, 750 mesh that pulverize and sieve after cleaning
It is uniformly mixed in water, is placed at 142 DEG C and steams 1.7h, filtered, obtain mixed liquor one and filter residue;(2) by sea cucumber intestine and mixed liquor one
Mixing, is placed under room temperature and stirs evenly, obtain mixed liquor two;(3) diatomite is pulverized and sieved into 850 mesh, is infiltrated with mixed liquor two
Afterwards, it is placed at 152 DEG C and steams 1.6h, take out, it is dry;(4) it is uniformly mixed with upper step gains after drying filter residue, is placed in 115
Steam 8h at DEG C, take out, it is dry to get.
Comparative example 1
Only contain dust-brand reindeer moss in raw material, other preparation processes are consistent with embodiment 3.
Comparative example 2
Snowy tea is contained only in raw material, other preparation processes are consistent with embodiment 3.
Comparative example 3
Only contain dust-brand reindeer moss and snow tea in raw material, other preparation processes are consistent with embodiment 3.
Comparative example 4
Compared with Example 3, raw material is identical, and preparation process uses common process:By 33.2 parts of long sunglo, dust-brand reindeer moss
18.7 parts and 6.1 parts of tea of snow are dry after cleaning, pulverize and sieve 750 mesh, and 52.6 parts of mixing of deionized water, mistake after decoction is then added
Filter, obtains filtrate and filter residue;8.2 parts of 3.5 parts of diatomite and sea cucumber intestine are dried after mixing with filtrate, then mixed with filter residue
Uniformly, then dry to get.
Experimental example
Above-described embodiment 1-3 and comparative example 1-4 the antiallergic composition prepared are subjected to clinic trial observation.Observe object:
15-50 Sui women of age.Choosing face has the women 700 of different degrees of allergic skin problem.Observation method:Daily sleep
It is applied on the face after preceding plus water mixing, second day is cleaned.10 days as a treatment course are used continuously.
Criterion of therapeutical effect:It is effective:Allergic symptom subsides up to 95% or more, and rubefaction, pruritis disappear, and skin has obviously
Moist smooth feeling;Effectively:70% or more allergic symptom recession, rubefaction, pruritis are obviously improved, and skin has significantly
Moist smooth feeling;In vain:It is unchanged before and after treatment.Test result is shown in Table 1.
1 clinical trial results of table
Project | Obvious effective rate % | Efficient % | Inefficiency % | Total effective rate % |
Embodiment 1 | 78 | 20 | 2 | 98 |
Embodiment 2 | 82 | 17 | 1 | 99 |
Embodiment 3 | 80 | 20 | 0 | 100 |
Comparative example 1 | 2 | 12 | 86 | 14 |
Comparative example 2 | 7 | 9 | 82 | 18 |
Comparative example 3 | 51 | 20 | 29 | 71 |
Comparative example 4 | 61 | 22 | 17 | 83 |
Model case:
Shandong Lee, female, 25 years old, anaphylaxis skin quality was controlled using preferable curative effect is showed no after other commercially available allergenic products
When treatment face since allergy has risen many red measles, ache not only but also itch, skin many places useless fellow is festered, and patient's body and mind is impaired, and night is not
It can sleep;It attempts to use the present composition, after first day smears, pain disappears, and after being used continuously 3 days, measles obviously subside,
Useless fellow starts to heal, and after being used continuously 7 days, measles disappear substantially, and useless fellow healing incrustation falls off, and after being used continuously 9 days, skin is extensive
Multiple normal condition, and feel that feel is smooth, and no scar marking for stiffening effect, and is continuing with 3 days.It deactivates 6 months,
Period is without recurrence.
Shandong Lee, man, 32 years old, anaphylaxis skin quality was right using being showed no preferable curative effect after other commercially available allergenic products
Catkin allergy.It is annual to be perplexed deeply by catkin.It floats the wadding previous moon in catkin, is deactivated after 7 days using the composition of the present invention.It floats willow
It wads a quilt with cotton season, does not occur allergic phenomena.And deactivate 6 months at present, during which without recurrence.
Theoretical foundation:
Long sunglo:It is clearing heat and detoxicating, relieving cough and reducing sputum.
Dust-brand reindeer moss:Nature and flavor:Hardship, it is cool in nature;Channel tropism:Liver Channel;Major function:Wind-expelling pain-stopping.Cure mainly inclined, aching all over the head, dizziness.
Avenge tea:Heat-clearing is quenched one's thirst, refreshment and tranquilization, blood pressure lowering, blood fat.Consumptive disease hectic fever due to yin is controlled, pneumonia cough, epilepsy is manic, nerve
It is weak, hypertension.
Diatomite:Diatomaceous chemical composition is mainly SiO2, contain a small amount of Al2O3、Fe2O3, CaO, MgO etc. and organic
Matter.
Sea cucumber intestine:Sea cucumber intestine is sea cucumber casing, sea cucumber ovum.According to modern nutriology analytical proof, sea cucumber intestine not only with sea
Ginseng body wall contains same abundant active material, and many precious nutrient content highers, such as polysaccharide, vanadium, nucleic acid, arginine
Deng;Sea cucumber intestine ovum also contains the ingredients such as extremely abundant sexual gland pigment, stichopus japonicus lipid, stichopus japonicus saponin, selenium, zinc, iron.
The better embodiment of this patent is explained in detail above, but this patent is not limited to above-mentioned embodiment party
Formula, one skilled in the relevant art within the scope of knowledge, can also be under the premise of not departing from this patent objective
It makes a variety of changes.
Claims (8)
1. a kind of antiallergic composition, which is characterized in that the antiallergic composition includes the raw material of following parts by weight:Long sunglo
25-38 parts, 14-22 parts of dust-brand reindeer moss avenges 3-9 parts of tea, 2-5 parts of diatomite, 5-10 parts of sea cucumber intestine, 40-80 parts of deionized water.
2. antiallergic composition according to claim 1, which is characterized in that the antiallergic composition includes following parts by weight
Several raw materials:It is sunglo 29-36 parts long, 17-20 parts of dust-brand reindeer moss, avenge 5-8 parts of tea, 3-4 parts of diatomite, 6-9 parts of sea cucumber intestine, go from
Sub- water 47-70 parts.
3. antiallergic composition according to claim 1, which is characterized in that the antiallergic composition includes following parts by weight
Several raw materials:33.2 parts of long sunglo, 18.7 parts of dust-brand reindeer moss avenge 6.1 parts of tea, 3.5 parts of diatomite, 8.2 parts of sea cucumber intestine, deionization
52.6 parts of water.
4. a kind of preparation method of antiallergic composition as described in any one of claims 1-3, which is characterized in that including following step
Suddenly:(1)It is dry after long sunglo, dust-brand reindeer moss and snow tea are cleaned respectively, pulverize and sieve 400-800 mesh, then by long sunglo powder,
Dust-brand litmus powder and snow tea powder are uniformly mixed, and are added in deionized water and are uniformly mixed, are placed at 130-145 DEG C and steam 1-2h, mistake
Filter, obtains mixed liquor one and filter residue;(2)Sea cucumber intestine is mixed with mixed liquor one, is placed under room temperature and stirs evenly, obtain mixed liquor
Two;(3)Diatomite is pulverized and sieved into 700-900 mesh, after being infiltrated with mixed liquor two, is placed at 140-158 DEG C and steams 1-2h, take
Go out, it is dry;(4)It is uniformly mixed with upper step gains after filter residue is dried, is placed at 100-120 DEG C and steams 5-10h, taken out, done
It is dry to get.
5. the preparation method of antiallergic composition as claimed in claim 4, which is characterized in that step(1)By long sunglo, dust-brand stone
Then drying, 600 mesh that pulverize and sieve after stamen and snow tea are cleaned respectively mix long sunglo powder, dust-brand litmus powder and snow tea powder equal
It is even, it is added in deionized water and is uniformly mixed, be placed at 135 DEG C and steam 1.3h, filter, obtain mixed liquor one and filter residue.
6. the preparation method of antiallergic composition as claimed in claim 4, which is characterized in that step(3)Diatomite crushed
800 mesh are sieved, after being infiltrated with mixed liquor two, is placed at 148 DEG C and steams 1.6h, are taken out, it is dry.
7. the preparation method of antiallergic composition as claimed in claim 4, which is characterized in that step(4)After filter residue is dried with
Upper step gains are uniformly mixed, and are placed at 110 DEG C and are steamed 7h, are taken out, it is dry to get.
8. a kind of antiallergic composition as described in any one of claims 1-3 answering in the cosmetics for preparing treatment skin allergy
With.
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