CN108489925A - A kind of instrument with breathing detection Malignant gastrointestinal pathogenic bacteria - Google Patents
A kind of instrument with breathing detection Malignant gastrointestinal pathogenic bacteria Download PDFInfo
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- CN108489925A CN108489925A CN201810302546.0A CN201810302546A CN108489925A CN 108489925 A CN108489925 A CN 108489925A CN 201810302546 A CN201810302546 A CN 201810302546A CN 108489925 A CN108489925 A CN 108489925A
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- 238000001514 detection method Methods 0.000 title claims abstract description 49
- 230000029058 respiratory gaseous exchange Effects 0.000 title claims abstract description 16
- 244000052616 bacterial pathogen Species 0.000 title claims description 14
- 230000002496 gastric effect Effects 0.000 title claims description 14
- 230000003211 malignant effect Effects 0.000 title claims description 14
- 238000012360 testing method Methods 0.000 claims abstract description 34
- 238000012545 processing Methods 0.000 claims abstract description 16
- 230000003019 stabilising effect Effects 0.000 claims abstract description 15
- 230000005622 photoelectricity Effects 0.000 claims abstract description 8
- 239000007789 gas Substances 0.000 claims description 173
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 238000005259 measurement Methods 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 239000002808 molecular sieve Substances 0.000 claims description 6
- 238000010926 purge Methods 0.000 claims description 6
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 claims description 6
- 229910001220 stainless steel Inorganic materials 0.000 claims description 6
- 239000001307 helium Substances 0.000 claims description 5
- 229910052734 helium Inorganic materials 0.000 claims description 5
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical group [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 claims description 5
- 230000007935 neutral effect Effects 0.000 claims description 5
- 238000006243 chemical reaction Methods 0.000 claims description 3
- 238000009826 distribution Methods 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 238000001179 sorption measurement Methods 0.000 claims description 3
- 239000010935 stainless steel Substances 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 claims description 2
- 230000006698 induction Effects 0.000 claims description 2
- 238000005498 polishing Methods 0.000 claims description 2
- 244000005709 gut microbiome Species 0.000 abstract description 2
- MWUXSHHQAYIFBG-UHFFFAOYSA-N nitrogen oxide Inorganic materials O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 24
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 description 13
- 238000000034 method Methods 0.000 description 8
- 239000001301 oxygen Substances 0.000 description 7
- 229910052760 oxygen Inorganic materials 0.000 description 7
- 210000002784 stomach Anatomy 0.000 description 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 6
- OKTJSMMVPCPJKN-OUBTZVSYSA-N Carbon-13 Chemical compound [13C] OKTJSMMVPCPJKN-OUBTZVSYSA-N 0.000 description 6
- 241000590002 Helicobacter pylori Species 0.000 description 6
- 229910052799 carbon Inorganic materials 0.000 description 6
- 229940037467 helicobacter pylori Drugs 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 5
- 208000015181 infectious disease Diseases 0.000 description 5
- 238000005070 sampling Methods 0.000 description 5
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- OKTJSMMVPCPJKN-IGMARMGPSA-N Carbon-12 Chemical compound [12C] OKTJSMMVPCPJKN-IGMARMGPSA-N 0.000 description 4
- 208000007882 Gastritis Diseases 0.000 description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- TYXNQDAIWMHZAY-UHFFFAOYSA-N [C].NC(N)=O Chemical compound [C].NC(N)=O TYXNQDAIWMHZAY-UHFFFAOYSA-N 0.000 description 4
- 239000012159 carrier gas Substances 0.000 description 4
- 238000013461 design Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 206010006326 Breath odour Diseases 0.000 description 3
- 208000032139 Halitosis Diseases 0.000 description 3
- 206010019375 Helicobacter infections Diseases 0.000 description 3
- 238000001574 biopsy Methods 0.000 description 3
- 208000023652 chronic gastritis Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 description 2
- 239000000292 calcium oxide Substances 0.000 description 2
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 238000001764 infiltration Methods 0.000 description 2
- 230000008595 infiltration Effects 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000011505 plaster Substances 0.000 description 2
- 210000001187 pylorus Anatomy 0.000 description 2
- 230000000306 recurrent effect Effects 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 238000010183 spectrum analysis Methods 0.000 description 2
- OKTJSMMVPCPJKN-NJFSPNSNSA-N Carbon-14 Chemical compound [14C] OKTJSMMVPCPJKN-NJFSPNSNSA-N 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- 208000008469 Peptic Ulcer Diseases 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 108010046334 Urease Proteins 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 229940095564 anhydrous calcium sulfate Drugs 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 208000018685 gastrointestinal system disease Diseases 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000012134 rapid urease test Methods 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/3504—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing gases, e.g. multi-gas analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/22—Devices for withdrawing samples in the gaseous state
- G01N1/24—Suction devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/34—Purifying; Cleaning
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- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pathology (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The present invention relates to medical fields, especially use the instrument of breathing detection gut bacteria, it specifically includes, gas circuit end, air intake pump, pretreatment unit, processing stabilising arrangement, pressure gauge, asepwirator pump and infrared test device, drier is provided on the pretreatment unit, the gas circuit end, air intake pump, pretreatment unit, processing stabilising arrangement, pressure gauge and asepwirator pump are sequentially connected by pipeline；The infrared test device includes intermediate gas flow path, infrared light supply, infrared sensing detection piece, be equipped with electric frequency modulation cuts photoelectricity machine and mechanical copped wave, it is provided with gas access and gas vent in the intermediate gas flow path, the gas access is connected by pipeline with asepwirator pump, the infrared light supply and infrared sensing detection piece are located at the both sides of intermediate gas flow path, it is described electric frequency modulation is installed cut photoelectricity machine between intermediate gas flow path and infrared light supply, the instrument accuracy in detection is high, detect wide variety, have been widely used in medical field of fast detection tool.
Description
Technical field
The present invention relates to medical field more particularly to a kind of instruments with breathing detection gut bacteria.
Background technology
In recent years medical data shows that the gastrointestinal disease of Chinese people takes place frequently and obstinate, such as halitosis, gastritis chronic diseases
Disease, there are Helicobacter pylori infections for the Patients with Chronic Gastritis of 60% or more investigation display.Therefore, it timely diagnoses and eradicates deep and remote
Door helicobacter infection is to block stomach trouble recurrent exerbation, and curing the Patients with Chronic Gastritis of 60% or more the premise of stomach trouble, there are pyloruses
Helicobacter infection.Therefore, timely diagnosis and eliminating pylorus infection are to block stomach trouble recurrent exerbation, healing stomach trouble
Premise, the diseases such as helicobacter pylori (HP) and chronic gastritis, peptic ulcer and gastric cancer have close relationship,
Therefore increasingly paid attention to by clinician.There are many ways to detecting HP infection, common rapid urease test need to be
Carried out under gastroscope, there is certain pain, and be not suitable for merging severe cardiac, brain, pulmonary disease patient, therefore have certain
Limitation.Currently, the inspection of stomach Hp infection includes invasive and non-invasive two classes method.It is invasive to check such as biopsy under gastroscope
Biopsy bacteriology checking etc. under biopsy bacterial cultivation and gastroscope under rapid urease, gastroscope;Noninvasive test has serum antibody
It checks, Helicobacter pylori stool antigen detects, (13 C) breath test of urea carbon 13 and urea carbon 14 (14 C) are exhaled
Gas experiment etc., wherein serum antibody method and the detection of excrement Hp antigens need patient to draw blood or stay stool, cumbersome, urea carbon 14
Though breath test is convenient and efficient, subject is made to generate misgivings because using radionuclide carbon 14.At present both at home and abroad detection by
The concentration generally use mass spectrograph of the CO2 of C13 and C12 compositions, the infrared sensing detection detections such as spectrometer, mass spectrograph and infrared
The cost of sensing detection spectrometer is all very high, and about 50~1,000,000, and needed more each two moon when use mass spectrograph detection
Change one bottle of argon gas, this can cause use cost very high, and it is inaccurate that existing high accuracy analysis class equipment all has a sampling, there are air and
Other impurities, which are mixed into, lets out the problem of altering string, testing result easily caused by by external environment and temperature bias contribution, bleed pressure it is steady
Qualitative bad, the gas flow application condition sucked every time is big, causes carbon dioxide different to the absorption of infrared light, to tested
Concentration measurements have an impact, while containing large quantity of moisture in the gas of people's exhalation, and the sealing of acquisition gas circuit is entered with gas
Piece has corrosiveness, can also influence measurement result, and in addition existing equipment lacks counterpart odour and (13 C of urea carbon 13
) exhale separation and detection process, it is therefore desirable to deeper into urea breath test of studying and improving be that a kind of Noninvasive detects
Means, to be used for solving the above problems.
Invention content
A series of concept of reduced forms is introduced in Summary, this will in the detailed description section into
One step is described in detail.The Summary of the present invention is not meant to attempt to limit technical solution claimed
Key feature and essential features do not mean that the protection domain for attempting to determine technical solution claimed more.
To solve the above-mentioned problems, the invention discloses a kind of instrument with breathing detection Malignant gastrointestinal pathogenic bacteria,
It is described pre- including gas circuit end, air intake pump, pretreatment unit, processing stabilising arrangement, pressure gauge, asepwirator pump and infrared test device
Drier, the gas circuit end, air intake pump, pretreatment unit, processing stabilising arrangement, pressure gauge and air-breathing are provided in processing unit
Pump is sequentially connected by pipeline；The infrared test device include intermediate gas flow path, infrared light supply, infrared sensing detection piece,
Be equipped with electric frequency modulation cuts photoelectricity machine and mechanical copped wave, and gas access and gas vent are provided in the intermediate gas flow path,
The gas access is connected by pipeline with asepwirator pump, and the infrared light supply and infrared sensing detection piece are located at intermediate gas
The both sides in channel, it is described electric frequency modulation is installed cut photoelectricity machine between intermediate gas flow path and infrared light supply, the machinery
Copped wave is between intermediate gas flow path and infrared sensing detection piece, it is characterised in that：Gas circuit end further includes what front end connected
Gas collecting control port, the gas collecting control port includes that gas vacuum pump and exhaled gas is taken to receive box, described
Gas vacuum pump is taken to be one equipped with induction control vacuum pump and compare gas circuit conversion and control end, pressure display system and circuit system
Instrument box, described to take gas vacuum pump to pass through connecting tube to connect a three-way magnetic valve, the another two-way of the three-way magnetic valve connects
What is connect is that helium purge gas circuit and exhaled gas receive box gas circuit, and corresponding gas circuit, institute are connected to by the switching of three-way magnetic valve
The pressure display system stated receives pressure condition in gauge measurement system in box gas circuit, institute using exhaled gas is set to
It is pressure vessel that the exhaled gas stated, which receives box, and the box body top is equipped with air inlet pipe and an air outlet pipe, air inlet pipe connection
One box body three-way magnetic valve, the escape pipe connect a control valve；Box is received to carry out vacuumizing work exhaled gas
When, the another two-way connection of the box body three-way magnetic valve is to take gas vacuum pump and emptying gas circuit；It is described when carrying out gas production work
The another two-way connection of box body three-way magnetic valve be insufflation channel and emptying gas circuit, the control valve connects gas circuit end to realize
Gas production controls and carries out follow-up test.
Optionally.It is provided with heating apparatus and circulating pump in the pretreatment unit.
Optionally, the gas circuit end further includes removing oxygen unit and de-watering apparatus.
Optionally, the processing stabilising arrangement further includes neutral adjusting molecular sieve device and vaporous water drying device.
Optionally, the circuit system includes 220V power input interfaces and air-breathing switch pump, and the instrument box is matched
It is equipped with stainless steel faceplate, distribution pressure table on panel, three-way magnetic valve valve handle, power input interface, air-path interface and asepwirator pump
Switch, the pressure gauge are regulation and control pressure gauge.
Optionally, it is cylinder pressure container that the exhaled gas, which receives box, and tray interior is by polishing, cleaning and prevents
Adsorption treatment.
Optionally, the exhaled gas receives box to make box body using 316L stainless steels, and box body thickness is 2 .5mm, internal
A diameter of 68mm, height 85mm, volume 0.18L, the air inlet pipe and an air outlet pipe of box body top setting are to stretch out box body
38mm and outer diameter are the gas circuit pipe of 6mm, and length of the air inlet pipe in box body is 60mm, and length of the escape pipe in box body is
18mm。
Beneficial effects of the present invention are as follows：The present invention mainly completes the collection to tester's gas and survey by air-channel system
Function is measured, realizes the collection of gas by controlling air pump and solenoid valve conduction, acquisition control port of the invention prevents non-inspection
It surveys the entrance of gas and prevents the gas of special detected gas from wearing and let out with stagnant, design gas circuit end realizes the row to vapor and oxygen
Divided by ensure subsequently measure accurate and to the stable operation of instrument and the guarantee in service life, cross pretreatment unit gas is carried out it is permanent
Warm constant pressure ensures the scientific and stability of detection, and counterpart odour and carbon 13 and carbon 12 are realized using processing stabilising arrangement
Differentiation and separation further ensure the accurate of detection, the absorption due to carbon 13 and carbon 12 and halitosis sulfide to feux rouges
Peak is different, and the energy value exported according to infrared detector can measure 12 concentration of carbon 13 and carbon in gas, to calculate
Nitrogen oxides and sulfide percentage composition in enzyme.Resource can be effectively saved, testing efficiency, the easy easily behaviour of test event are improved
Make, test result is accurate.Master control system is 13 infrared sensing of carbon detection spectrometer, at the same realize to air-channel system air pump and
The control of solenoid valve, carbon potential element（12C and 13C）The processing of concentration data, the human-computer interaction output of test result and net
Network upload function.The present invention is designed exclusively for insufflation channel, exhalation sample gas that can be in collection site insufflation channel, convenient for profit
The content of the wherein various components of spectrometer analysis is detected with special infrared sensing, the instrument accuracy in detection is high, to judging
Helicobacter pylori and sulfide type saprophytic bacteria provides powerful foundation there are situation, for the treatment of infection in stomach.
Gas producing device reasonable design of the present invention detects wide variety, greatly reduces the infiltration of air, effectively prevent feature group
String is let out in the delay divided, to enhance the reliability of analysis result so that entire spectral-analysis process is more safe and effective, real
Now precisely test.
Description of the drawings
The following drawings of embodiment of the present invention is used to understand the present invention in this as the part of the present invention.Show in attached drawing
Embodiments of the present invention and its description, principle used to explain the present invention are gone out.In the accompanying drawings,
Fig. 1 is the structural schematic diagram of the instrument of the embodiment of the present application breathing detection Malignant gastrointestinal pathogenic bacteria；
Fig. 2 is the infrared sensing partial schematic diagram of the instrument of the embodiment of the present application breathing detection Malignant gastrointestinal pathogenic bacteria；
Fig. 3 is connection relationship diagram when gas producing device of the present invention receives box to carry out vacuumizing work exhaled gas；
Fig. 4 is that gas producing device of the present invention carries out connection relationship diagram when gas production work.
Specific implementation mode
In the following description, a large amount of concrete details are given in order to provide more thorough understanding of the invention.So
And it will be apparent to one skilled in the art that embodiment of the present invention may not need it is one or more of these thin
It saves and is carried out.In other examples, in order to avoid obscuring with embodiment of the present invention, for well known in the art
Some technical characteristics are not described.
In order to thoroughly understand embodiment of the present invention, detailed structure will be proposed in following description.Obviously, of the invention
The execution of embodiment is not limited to the specific details that those skilled in the art is familiar with.The better embodiment of the present invention
It is described in detail as follows, however other than these detailed descriptions, the present invention can also have other embodiment.
See Fig. 1 to Fig. 4 first, the instrument of the present embodiment breathing detection Malignant gastrointestinal pathogenic bacteria include gas circuit end 1,
Air intake pump 2, pretreatment unit 3, processing stabilising arrangement 4, pressure gauge 5, asepwirator pump 6 and infrared test device 7, wherein pretreatment
Heating apparatus, circulating pump and drier 31 are provided in device 3, gas circuit end 1 includes removing oxygen unit 11 and de-watering apparatus
12, processing stabilising arrangement 4 includes neutral adjusting molecular sieve device 41 and vaporous water drying device 42.Except in oxygen unit 11
Can be iron or calcium oxide, to remove the oxygen in carrier gas；De-watering apparatus 12 and vaporous water drying device 42 can be anhydrous
Calcium sulfate or anhydrous calcium chloride remove the moisture in the oxygen that moisture and exhalation in carrier gas generate respectively；Neutrality adjusts molecule
In screen device 41 can be the compound adsorbent containing aluminum hydroxide material, with absorb exhalation generate a small amount of impurity or it is non-in
Property substance.Gas circuit end 1 further includes the gas collecting control port 1111 being connected to except 11 front end of oxygen unit, with reference to the accompanying drawings 3 He
Attached drawing 4, a kind of instrument with breathing detection Malignant gastrointestinal pathogenic bacteria of the invention, body acquisition control port 1111 it include
Gas vacuum pump and exhaled gas is taken to receive box 115, described takes gas vacuum pump to be one equipped with small-sized asepwirator pump 112 and compare gas
Road conversion and control end, pressure display system and circuit system instrument box 111.The asepwirator pump 112 is fixed on instrument box 111
Bottom, and it is furnished with beam.The asepwirator pump 112 connects a three-way magnetic valve 113, three energizations by connecting tube
The connection of 113 another two-way of magnet valve is that helium purge gas circuit 119 and exhaled gas receive box gas circuit, passes through three-way magnetic valve 113
Switching is connected to corresponding gas circuit.The pressure display system receives pressure gauge in box gas circuit using exhaled gas is set to
Pressure condition in 114 measuring systems.It is pressure vessel that the exhaled gas, which receives box 115, and box body top is equipped with air inlet pipe
101 and escape pipe 211, the air inlet pipe 101 connects a box body three-way magnetic valve 116, and the escape pipe connects one
Control valve 117.When receiving box to carry out vacuumizing work exhaled gas, the 116 another two-way of box body three-way magnetic valve connection
Be take gas vacuum pump and emptying gas circuit 118.When carrying out gas production work, the 116 another two-way of box body three-way magnetic valve connection
Be that insufflation channel 120 and emptying gas circuit 118, the control valve 117 connect gas circuit end 1.
Further, the circuit system includes 220V power input interfaces and air-breathing switch pump.The instrument box
111 are configured with stainless steel faceplate, distribution pressure table on panel, three-way magnetic valve valve handle, power input interface, air-path interface and suction
Air pump switch.The pressure gauge uses regulation and control pressure gauge, the pressure condition in accurate display system.
Further, it is cylinder pressure container that the exhaled gas, which receives box 115, and tray interior, which passes through, to be polished, is clear
It washes and anti-adsorption treatment.The exhaled gas receives box 115 to make box body using 316L stainless steels, and box body thickness is 2 .5mm,
Inside diameter is 68mm, height 85mm, volume 0.18L, the air inlet pipe 101 and escape pipe 211 of box body top setting
To stretch out the gas circuit pipe that box body 38mm and outer diameter are 6mm, length of the air inlet pipe 101 in box body is 60mm, and escape pipe 211 is in box
Internal length is 18mm.
Further, in this embodiment infrared test device 7 include intermediate gas flow path 71, it is infrared light supply 72, red
Outer sensing detection piece 73, electric frequency modulation is installed cut photoelectricity machine 74 and mechanical copped wave 75, be provided in intermediate gas flow path 71
Gas access and gas vent, infrared light supply 72 and infrared sensing detection piece 73 are located at the two of intermediate gas flow path 71
Side, wherein infrared light supply 72 is located at close to the side of gas access, and infrared sensing detection piece 73 is located at close to gas vent
The electric frequency modulation on photoelectricity machine 74 is cut between intermediate gas flow path 71 and infrared light supply 72, mechanical copped wave 75 in side
Between intermediate gas flow path 71 and infrared sensing detection piece 73, light that infrared light supply 72 is sent out pass through successively electric frequency modulation,
Intermediate gas flow path 71 and mechanical copped wave 75 and reach infrared sensing detection piece 73.
De-watering apparatus 12 in the present embodiment is connected by pipeline and except oxygen unit 11, and air intake pump 2 passes through pipeline
It is connected with de-watering apparatus 12, the carrier gas inlet in pretreatment unit 3 is connected by pipeline and air intake pump 2, and neutrality adjusts molecule
Screen device 41 exports connection by the carrier gas in pipeline and pretreatment unit 3, and vaporous water drying device 42 is by pipeline in
Property adjust molecular sieve device 41 and connect, pressure gauge 5 is connected by pipeline and vaporous water drying device 42, and asepwirator pump 6 passes through
Pipeline and pressure gauge 5 connect, and the gas access in the intermediate gas flow path 71 of infrared test device 7 passes through pipeline and air-breathing
6 connection of pump, i.e., gas circuit end 1, air intake pump 2, pretreatment unit 3, processing stabilising arrangement 4 in the present embodiment, pressure gauge 5, air-breathing
Pump 6 and infrared test device 7 are sequentially connected by pipeline.
Further, the test gas enters before pretreatment unit 3, should pass through gas circuit end 1, to reach water removal and remove
The purpose of oxygen, water removal can use dead plaster or anhydrous calcium chloride, except oxygen can use iron or calcium oxide.Expiratory air
Body enters before infrared test device 7, also needs by handling stabilising arrangement, to reach water removal and the neutral mesh for adjusting molecular sieve
, the water vapour in exhaled gas can be removed through dead plaster, can remove expiratory air through granular anhydrous copper sulphate float stone
Zymolytic acid and alkali substance in body adjusts molecular sieve with neutral.
Infrared test device 7 in the application is non-dispersive infrared detecting system, can be according to nitrogen oxides and sulfide
To the concentration of the absorption measurement oxygen of specific wavelength infrared light.It is analyzed when operator starts, nitrogen oxides and sulfide is entered
Analytic process is put into pretreatment unit 3, asepwirator pump 6 presses certain flow, the gas for continuously generating exhalation
It is sequentially sent in the intermediate gas flow path 71 of processing stabilising arrangement and infrared test device 7, infrared test device 7 is finally discharged
Outside.Infrared sensing detection piece 73 continuously detects nitrogen oxides and sulfide gas concentration, then can be acquired through computer and soft
Part calculates, and obtains the absolute content of the exhaled gas nitrogen oxides and sulfide, also can be exchanged into the percentage composition of sample.
Infrared test device 7 in the present embodiment at work, what the light beam launched by infrared light supply 72 was rotated
Electric frequency modulation is modulated into interrupted light, and when infrared light is by intermediate gas flow path 71, part energy is by the nitrogen oxidation in gas
Object and sulfide molecules absorb, and the part that the intensity of light can be weakened, and not sponged is then penetrated from gas.Gas molecule is only
The infrared light of its characteristic wavelength is absorbed, the part other than characteristic wavelength is cut before reaching infrared sensing detection piece 73 by machinery
Wave 75, which blocks, to be passed through, and the strong and weak variation of infrared light is converted into voltage signal by infrared test device 7.According to lambert-ratio
That law, the degree that monochromatic light is actually taken up by gas（Absorbance）It is directly proportional to the concentration of the gas.Therefore, as long as measuring absorbance
It is assured that nitrogen oxides and sulfide content in nitrogen oxides and sulfide concentration and sample, the infrared absorption in the application
Method is a kind of measurement indirectly, it is often necessary to is corrected with standard substance and just can guarantee accuracy.So in instrument in use,
When finding that result has the tendency that overproof or change measuring condition, should all be corrected in time.
The working method and functions of the equipments effect of present device are as follows：First to exhaled gas in non-test gaseous environment
It receives box 115 to carry out vacuumizing purge, powers on, box body three-way magnetic valve 116 chooses exhaled gas and receives box 115
It is connected with gas vacuum pump is taken, the control valve 117 of box body is closed, and is extracted into after setting negative pressure, is cut by three-way magnetic valve 113
Ventilation road, helium purge gas circuit air inlet are purged using helium, and the control valve 117 of box body is opened, 2~3 times repeatedly,
Ensure that exhaled gas receives gas in box 115（Box 115 is received including exhaled gas and is taken in the connecting line between gas vacuum pump
Gas）It all removes, box body three-way magnetic valve 116 is in enclosed box body state, and control valve 117 is closed, to protect
It holds exhaled gas and receives negative pressure in box 115.When field sampling operates, needs first to connect exhaled gas and receive box 115 and blow
Gas channel 120, after purging connecting line for a period of time with sample gas, rotation box body three-way magnetic valve 116, insufflation channel
Gas in 120 can be entered exhaled gas due to pressure difference and be received in box 115, until pressure balance.In fashion described above to people
Body takes the gas sampling of the metabolism exhalation before and after mark substance, and after the completion of sampling, rotation box body three-way magnetic valve 116 makes to exhale
Going out gas receives box 115 to be in sealing state, and sampling work terminates.When needing to analyze sample gas, exhaled gas is connected
Receive 115 gentle terminal 1 of box that can analyze sample gas.Specific air-channel system mainly completes the receipts to tester's gas
Collection and measurement function realize that the collection of gas, acquisition control port of the invention are anti-by controlling air pump and solenoid valve conduction
It only the entrance of non-detection gas and prevents from the gas of special detected gas from wearing letting out with stagnant, design gas circuit end is realized to vapor and oxygen
The exclusion of gas crosses pretreatment unit to gas with ensure subsequently to measure accurate and to the stable operation of instrument and the guarantee in service life
It carries out constant temperature and pressure and ensures the scientific and stability of detection, counterpart odour and carbon 13 are realized using processing stabilising arrangement
Differentiation and separation with carbon 12 further ensure the accurate of detection, since carbon 13 and carbon 12 and halitosis sulfide are to red
The absorption peak of light is different, and the energy value exported according to infrared detector can measure 12 concentration of carbon 13 and carbon in gas, from
And nitrogen oxides and sulfide percentage composition in enzyme are calculated, detection type is wide, and test result is accurate, can effectively save money
Testing efficiency is improved in source, and test event is simple and easy to operate, and test result is accurate.Master control system is 13 infrared sensing detection light of carbon
Spectrometer, while the control to air-channel system air pump and solenoid valve is realized, carbon potential element（12C and 13C）Concentration data
Processing, the human-computer interaction output of test result and network upload function.The present invention is designed exclusively for insufflation channel, can be acquired
Exhalation sample gas in live insufflation channel, convenient for detecting containing for the wherein various components of spectrometer analysis using special infrared sensing
Amount, to judging being provided by force there are situation, for the treatment of infection for helicobacter pylori and sulfide type saprophytic bacteria in stomach
And strong foundation.Gas producing device reasonable design of the present invention, greatly reduces the infiltration of air, effectively prevents feature group
String is let out in the delay divided, to enhance the reliability of analysis result so that entire spectral-analysis process is more safe and effective.
The present invention is illustrated by the above embodiment, but it is to be understood that, the above embodiment is
Purpose for illustrating and illustrating, and be not intended to limit the invention within the scope of described embodiment.In addition this field
It is understood that the invention is not limited in the above embodiment, introduction according to the present invention can also be made technical staff
More kinds of variants and modifications, these variants and modifications are all fallen within scope of the present invention.
Claims (7)
1. a kind of instrument with breathing detection Malignant gastrointestinal pathogenic bacteria, including gas circuit end, air intake pump, pretreatment unit, place
Stabilising arrangement, pressure gauge, asepwirator pump and infrared test device are managed, drier, the gas circuit are provided on the pretreatment unit
End, air intake pump, pretreatment unit, processing stabilising arrangement, pressure gauge and asepwirator pump are sequentially connected by pipeline；The infrared test
Device include intermediate gas flow path, infrared light supply, infrared sensing detection piece, be equipped with electric frequency modulation cut photoelectricity machine and machinery is cut
Wave is provided with gas access and gas vent in the intermediate gas flow path, and the gas access passes through pipeline and asepwirator pump connects
It connects, the infrared light supply and infrared sensing detection piece be located at the both sides of intermediate gas flow path, described to be equipped with electric frequency modulation
Photoelectricity machine is cut between intermediate gas flow path and infrared light supply, the machinery copped wave is located at intermediate gas flow path and infrared sensing
Between detection piece, it is characterised in that：The gas circuit end further includes the gas collecting control port of front end connection, the gas
Acquisition control port includes that gas vacuum pump and exhaled gas is taken to receive box, and described takes gas vacuum pump for one equipped with induction control
Vacuum pump and the instrument box at comparison gas circuit conversion and control end, pressure display system and circuit system, it is described that gas vacuum pump is taken to pass through
Connecting tube connects a three-way magnetic valve, and the another two-way connection of the three-way magnetic valve is helium purge gas circuit and exhaled gas
Box gas circuit is received, corresponding gas circuit is connected to by the switching of three-way magnetic valve, the pressure display system is used to be set to and be exhaled
Going out gas receives pressure condition in gauge measurement system in box gas circuit, the exhaled gas that box is received to hold for pressure
Device, the box body top are equipped with air inlet pipe and an air outlet pipe, and the air inlet pipe connects a box body three-way magnetic valve, and described goes out
Tracheae connects a control valve；When receiving box to carry out vacuumizing work exhaled gas, the box body three-way magnetic valve another two
Road connection is to take gas vacuum pump and emptying gas circuit；When carrying out gas production work, the another two-way connection of the box body three-way magnetic valve
Be insufflation channel and emptying gas circuit, the control valve connects gas circuit end and follow-up is precisely surveyed with realizing gas production control and realizing
Examination.
2. according to the instrument with breathing detection Malignant gastrointestinal pathogenic bacteria described in claim 1, it is characterised in that：It is described
Heating apparatus and circulating pump are provided in pretreatment unit.
3. according to the instrument with breathing detection Malignant gastrointestinal pathogenic bacteria described in claim 1, it is characterised in that：It is described
Gas circuit end further includes removing oxygen unit and de-watering apparatus.
4. according to the instrument with breathing detection Malignant gastrointestinal pathogenic bacteria described in claim 1, it is characterised in that：It is described
Processing stabilising arrangement further includes neutral adjusting molecular sieve device and vaporous water drying device.
5. according to the instrument with breathing detection Malignant gastrointestinal pathogenic bacteria described in claim 1, it is characterised in that：It is described
Circuit system include 220V power input interfaces and air-breathing switch pump, the instrument box is configured with stainless steel faceplate, panel
Upper distribution pressure table, three-way magnetic valve valve handle, power input interface, air-path interface and air-breathing switch pump, the pressure gauge are
Regulate and control pressure gauge.
6. according to the instrument with breathing detection Malignant gastrointestinal pathogenic bacteria described in claim 1, it is characterised in that：It is described
Exhaled gas receive box be cylinder pressure container, tray interior by polishing, cleaning and anti-adsorption treatment.
7. the instrument with breathing detection Malignant gastrointestinal pathogenic bacteria according to any type in claim 1 to 6,
It is characterized in that：The exhaled gas receives box to make box body using 316L stainless steels, and box body thickness is 2 .5mm, and inside diameter is
68mm, height 85mm, volume 0.18L, the box body top setting air inlet pipe and an air outlet pipe be stretch out box body 38mm and
Outer diameter is the gas circuit pipe of 6mm, and length of the air inlet pipe in box body is 60mm, and length of the escape pipe in box body is 18mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810302546.0A CN108489925A (en) | 2018-04-05 | 2018-04-05 | A kind of instrument with breathing detection Malignant gastrointestinal pathogenic bacteria |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810302546.0A CN108489925A (en) | 2018-04-05 | 2018-04-05 | A kind of instrument with breathing detection Malignant gastrointestinal pathogenic bacteria |
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| CN108489925A true CN108489925A (en) | 2018-09-04 |
Family
ID=63314653
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| CN201810302546.0A Pending CN108489925A (en) | 2018-04-05 | 2018-04-05 | A kind of instrument with breathing detection Malignant gastrointestinal pathogenic bacteria |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110376022A (en) * | 2019-07-26 | 2019-10-25 | 重庆德方信息技术有限公司 | Sampling sample presentation pipeline for intelligent closestool |
| CN113647892A (en) * | 2021-08-31 | 2021-11-16 | 广州市顺元医疗器械有限公司 | Water-gas conveying device for endoscope |
| CN114200087A (en) * | 2021-12-15 | 2022-03-18 | 杭州汇健科技有限公司 | Expiration tester and using method thereof |
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