CN108478658A - A kind of Ovulatory decoction and preparation method thereof - Google Patents

A kind of Ovulatory decoction and preparation method thereof Download PDF

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CN108478658A
CN108478658A CN201810524937.7A CN201810524937A CN108478658A CN 108478658 A CN108478658 A CN 108478658A CN 201810524937 A CN201810524937 A CN 201810524937A CN 108478658 A CN108478658 A CN 108478658A
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ovulatory
decoction
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CN108478658B (en
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白红艳
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/29Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A61K36/296Epimedium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/39Convolvulaceae (Morning-glory family), e.g. bindweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/43Cuscutaceae (Dodder family), e.g. Cuscuta epithymum or greater dodder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/533Leonurus (motherwort)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

A kind of Ovulatory decoction disclosed by the invention, includes each component of following mass fraction:18 25 parts of oriental wormwood, 18 25 parts of motherwort, 12 18 parts of Rhizoma Chuanxiong, 12 18 parts of dipsacus root, 12 18 parts of HERBA EPIMEDII, 15 18 parts of Radix Rehmanniae, 12 18 parts of Semen Cuscutae, 12 18 parts of Radix Paeoniae Alba, 10 15 parts of Radix Angelicae Sinensis, 5 10 parts of Radix Glycyrrhizae.The Ovulatory decoction of the present invention is by using oriental wormwood, enhance the body specific immune function of infertility patient, use motherwort promoting blood circulation for regulating menstruation, Stasis through, the tonifying kidney and strengthening yangs such as dipsacus root, HERBA EPIMEDII, Semen Cuscutae, life essence-filling, marrow-benefitting, the good kidney and spleen invigorating of energy, ovarian follicular growth promoting blood circulation and removing blood stasis, promoting infertility, Ovulatory decoction of the invention both not side effects of Western medicine are added simultaneously, facilitate clinician to grasp simultaneously, there is good practical value.

Description

A kind of Ovulatory decoction and preparation method thereof
Technical field
The invention belongs to drug preparation technique fields, and in particular to a kind of Ovulatory decoction, the invention further relates to a kind of decorporations The preparation method of ovum soup.
Background technology
The medical definition of infertility is not take any contraceptives in, and sexual life is normally without successful pregnancy.It is main It is divided into primary infertility and secondary infertility.Primary infertility is never to become pregnant;Secondary infertility is that once pregnancy was later and infertile.According to This stringent definition, infertile is a kind of common problem, about influences at least 10%~15% couple at child-bearing age.
Infertile pathogenic factor is caused to be divided into male infertility, female acyesis and unknown cause.Female acyesis with pelvic factors, Ovulation failure is main cause, and male infertility is mainly production of sperm exception and sperm drainage obstacle.
Female pelvic cavity factor accounts for the 35% of the infertility cause of disease, includes mainly:(1) oviduct abnormality, chronic fallopian tubal The locking of umbrella end or tunica mucosa tubae uterinae caused by inflammation destroy, and are infertile caused by fallopian tubal obstruction or ponding completely;(2) pelvic cavity is viscous Company, pelvic inflammation, endometriosis, Pelvic Tuberculosis etc. cause the extensive loose or fine and close connection in part, cause Pelvic cavity and fallopian tubal Gong Eng and structural damage;(3) Endometrial Diseases;(4) endometriosis;(5) fibroid; (6) neoplasmata genitalis;(7) genital tract developmental deformity.
Female ovulation obstacle accounts for the 25-35% of the infertility cause of disease, and main cause has:(1) Chronic anovulation;(2) Stein-Leventhal syndrome;(3) premature ovarian failure and hypo-ovaria;(4) congenital gonad development is bad;(5) low rush sexual gland swashs Disposition gonad function is bad;(6) hyperprolactinemia;(7) Luteinized ovarian follicle does not rupture syndrome etc..
The cause of disease of some ovulation failures is persistently existing, and some is then dynamic change, be cannot function as uniquely, absolutely And the lasting cause of disease be bound.For the confusion of the menstrual cycle, the age be more than 35 years old, ovary antral follicle count persistently reduce, The Mr. and Mrs of long-term unknown sterility first have to the cause of disease for considering ovulation failure.For the symptom of female ovulation obstacle, existing west The ovulation stimulants species of medicine are various, have tablet also to have injection;Tablet has apparent estrogen inhibiting effect, injection general doctor It is difficult to grasp, applicability is not strong, and by western medicine weak curative effect, and side effect is big.
Invention content
The object of the present invention is to provide a kind of Ovulatory decoction, solve through western medicine caused by female ovulation obstacle The big problem of infertility weak curative effect, side effect.
It is a further object to provide a kind of preparation methods of Ovulatory decoction.
The technical solution adopted in the present invention is that a kind of Ovulatory decoction includes each component of following mass fraction:Oriental wormwood 18-25 parts, 18-25 parts of motherwort, 12-18 parts of Rhizoma Chuanxiong, 12-18 parts of dipsacus root, 12-18 parts of HERBA EPIMEDII, 15-18 parts, Tu of Radix Rehmanniae It is 12-18 parts sub-, 12-18 parts of Radix Paeoniae Alba, 10-15 parts of Radix Angelicae Sinensis, 5-10 parts of Radix Glycyrrhizae.
Second technical solution of the invention is that a kind of preparation method of Ovulatory decoction includes the following steps:
Step 1, each component is weighed according to following mass fraction:18-25 parts of oriental wormwood, 18-25 parts of motherwort, Rhizoma Chuanxiong 12-18 Part, 12-18 parts of dipsacus root, 12-18 parts of HERBA EPIMEDII, 15-18 parts of Radix Rehmanniae, 12-18 parts of Semen Cuscutae, 12-18 parts of Radix Paeoniae Alba, Radix Angelicae Sinensis 10-15 Part, 5-10 parts of Radix Glycyrrhizae;
Step 2, each component material mixing step 1 weighed, and obtained mixture is placed in marmite, add simultaneously Enter tap water immersion;
Step 3, by step 2, treated after mixture is boiled by fire, and conversion slow boiling decocts, and then filters, obtains filter residue And first-time filtrate;
Step 4, tap water is continuously added in the filter residue of step 3, boils rear slow boiling and decocts, then filtered, obtain secondary Filtrate;
Step 5, it after the secondary filtrate of the first-time filtrate of step 3 and step 4 being mixed, filters again, obtained filtrate is i.e. For Ovulatory decoction.
It is of the invention to be further characterized in that,
The volume of tap water is 300-500ml in step 2, or originally water volume there was not mixture 2-3cm.
Soaking time is 0.5-1h in step 2.
Slow boiling decocting time is 30-40min in step 3.
The originally water volume being added in step 4 is 200-300ml, or originally water volume there was not filter residue 1-2cm.
Slow boiling decocting time is 20-30min in step 4.
The beneficial effects of the invention are as follows:A kind of Ovulatory decoction of the present invention is suffered from by using oriental wormwood, enhancing infertility The body specific immune function of person using motherwort promoting blood circulation for regulating menstruation, Stasis through, while adding dipsacus root, HERBA EPIMEDII, Semen Cuscutae Equal tonifying kidney and strengthening yangs, life essence-filling, marrow-benefitting, the good kidney and spleen invigorating of energy, ovarian follicular growth promoting blood circulation and removing blood stasis, promoting infertility, the present invention Ovulatory decoction both not side effects of Western medicine, while clinician being facilitated to grasp, there is good practical value.
Specific implementation mode
Below by specific embodiment, the present invention is described in detail.
One, the prescription and content of Chinese medicine composition of the invention
A kind of Ovulatory decoction includes each component of following mass fraction:18-25 parts of oriental wormwood, 18-25 parts of motherwort, Rhizoma Chuanxiong 12-18 parts, 12-18 parts of dipsacus root, 12-18 parts of HERBA EPIMEDII, 15-18 parts of Radix Rehmanniae, 12-18 parts of Semen Cuscutae, 12-18 parts of Radix Paeoniae Alba, Radix Angelicae Sinensis 10-15 parts, 5-10 parts of Radix Glycyrrhizae.
A kind of preparation method of above-mentioned Ovulatory decoction, specifically implements according to the following steps:
Step 1, each component is weighed according to following mass fraction:18-25 parts of oriental wormwood, 18-25 parts of motherwort, Rhizoma Chuanxiong 12-18 Part, 12-18 parts of dipsacus root, 12-18 parts of HERBA EPIMEDII, 15-18 parts of Radix Rehmanniae, 12-18 parts of Semen Cuscutae, 12-18 parts of Radix Paeoniae Alba, Radix Angelicae Sinensis 10-15 Part, 5-10 parts of Radix Glycyrrhizae;
Step 2, each component material mixing step 1 weighed, and obtained mixture is placed in marmite, add simultaneously Enter tap water and impregnates 0.5-1h;
Wherein the volume of tap water is 300-500ml, or originally water volume there was not mixture 2-3cm.
Step 3, by step 2, treated after mixture is boiled by fire, and conversion slow boiling decocts 30-40min, then filters, Obtain filter residue and first-time filtrate;
Step 4, tap water is continuously added in the filter residue of step 3, boils rear slow boiling and decocts 20-30min, then filtered, Obtain secondary filtrate;
Wherein originally water volume is 200-300m, or originally water volume there was not filter residue 1-2cm.
Step 5, it after the secondary filtrate of the first-time filtrate of step 3 and step 4 being mixed, filters again, obtained filtrate is i.e. For Ovulatory decoction.
Two, each prescription function and major function
1, the present invention in each component function:
Oriental wormwood:The oriental wormwood of selection is feverfew, bitter, pungent, cold nature, returns spleen, stomach, liver, gallbladder channel;It is apt to clear dampness removing Heat containing compositions such as cumarin, flavones, organic acids, can reinforce body specific immune function.
Motherwort:The motherwort of selection is labiate, bitter in taste, pungent, be slightly cold, Return liver, the heart, Bao Jing;Promoting blood circulation for regulating menstruation, Stasis through is mainly used for through uncomfortable, dysmenorrhoea, amenorrhoea.
Rhizoma Chuanxiong:The Rhizoma Chuanxiong of selection is samphire, and nature and flavor are acrid in flavour and warm in nature, Return liver, courage, the heart channel of Hang-Shaoyin;Promoting blood circulation tonifying Qi, wind-expelling pain-stopping, It is mainly used to irregular menstruation, closed dysmenorrhea;The promoting flow of qi and blood circulation is the gas medicine in blood, relieving stagnation in lower menstruation regulating water.
Dipsacus root:The dipsacus root Dipsacaceae plant of selection, bitter in taste, pungent, tepor returns liver and kidney channel;Filling liver kidney, strengthening the bones and muscles continue Injured, only uterine bleeding.It is mainly used to tonify the liver and kidney, promotes developing womb.
HERBA EPIMEDII:Famous longspur epimedium, smell is pungent, warm, nontoxic, has tonifying kidney and strengthening yang, life essence-filling, marrow-benefitting, dispelling wind and eliminating dampness, strengthening tendons strong The effect of bone, is mainly used to impotence and seminal emission, empty cold infertility, frequent micturition incontinence, dyspnea and cough due to deficiency of the kidney, soreness and weakness of waist and knees, arthralgia pain due to rheumatism, half body not Then, four limbs are meciless.
Radix Rehmanniae:The Radix Rehmanniae of selection is goatweed, and nature and flavor are sweet, is trembled with fear, the thoughts of returning home, liver, kidney channel;Clearing heat and cooling blood, nourishing Yin and promoting production of body fluid, Replenishing essence benefit marrow.
Semen Cuscutae:The Semen Cuscutae of selection is convolvulaceous plant, and nature and flavor are sweet, warm, Return liver, kidney, the spleen channel;Enriching yin and nourishing kidney, tocolysis, Tonifying kidney and benefiting sperm, nourishing the liver benefit, are mainly used for vaginal bleeding due to deficiency of the kidney during pregnancy, fetal irritability.
Radix Paeoniae Alba:The Radix Paeoniae Alba of selection is ranunculaceae plant;Cold nature, bitter, acid, return liver warp, the spleen channel;Blood-nourishing hold back cloudy, soft liver, Smooth liver and relieve pain, nourishing blood for regulating menstruation, astringing YIN to stop sweating.
Radix Angelicae Sinensis:Working as selecting is classified as umbellate form section plant, and nature and flavor are sweet, pungent, warm, Return liver, the heart, the spleen channel;Replenishing and activating blood, menstruation regulating stop Bitterly, blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, Amenorrhea promoting menstruation are mainly used to.
Radix Glycyrrhizae:The Radix Glycyrrhizae of selection is legume, and nature and flavor are sweet, flat, the thoughts of returning home, lung, spleen, stomach;It invigorates the spleen and benefits qi, heat-clearing solution Poison concocts all medicines, is mainly used for weakness of the spleen and the stomach, lassitude hypodynamia.
Through clinical observation of celebrating the New Year or the Spring Festival, in ovulation failure patient, polycystic ovary person is on the high side, and dietary structure improves in addition, and it is pungent to throw off restraint food Peppery rich, build is partially fat, therefore with kind eliminating dampness and heat, the oriental wormwood for improving immunity of organism is monarch drug in a prescription, and master enters the motherwort promoting blood circulation of blood system Menstruation regulating, Stasis through be ministerial drug, assistant with warm dipsacus root, HERBA EPIMEDII, Semen Cuscutae tonifying kidney and strengthening yang, life essence-filling, marrow-benefitting, Radix Rehmanniae, Radix Paeoniae Alba support Yin and promoting production of body liquid, nourishing blood and liver, relieving stagnation in rhizome of chuanxiong, Radix Angelicae Sinensis inrigorating qi and promoting blood circulation, the damp and hot double clear, liver-kidney tonifyings in full side, the promoting flow of qi and blood circulation, replenishing essence The sub- progestogenic of benefit.
2, major function:
The Ovulatory decoction of the present invention cures mainly the infertility caused by female ovulation obstacle.
3, usage and dosage:
The Ovulatory decoction that preparation method of the present invention is obtained is pan-fried good spare, takes orally, and twice daily, getting up early is primary on an empty stomach, evening On sleep before half an hour take once;5-7 pays as a treatment course.
Taking phase prohibits cold water wash up, drenches with rain, and prohibits the raw and cold food of food and drink, should not drink Aqua Folium Camelliae sinensis.
Three, clinical case
Case 1
1. conditions of patients and its basic condition
38 years old A age of patient does not practise contraception more than 2 years, usually menstruation rule, health;B ultrasound shows that uterus wheel is cleaned up It is clear, form is regular, uterus and its double accessory area are shown no obvious abnormalities;X-ray inspection shows that hysterography form is shown no obvious abnormalities, Left side fallopian tubal is basic in general, right side fallopian tubal is logical and unsmooth;It is secondary sterility after diagnosing.
2. therapy
The Ovulatory decoction that preparation method of the present invention is obtained is pan-fried good spare, takes orally, and twice daily, getting up early is primary on an empty stomach, evening On sleep before half an hour take once;1 course for the treatment of of medication, totally 6 pairs.
Taking phase prohibits cold water wash up, drenches with rain, and prohibits the raw and cold food of food and drink, should not drink Aqua Folium Camelliae sinensis.
3. treatment results
Detection ovulation table after the tablet has been ingested, as shown in table 1:
1 patient A of table takes the monitoring ovulation table after 6 pairs of Ovulatory decoctions
It does not rise from the menstruation of drug administration month to next month, patient shows as the discomforts such as mammary swelling nausea, and B ultrasound shows in utero early It is pregnant.
Case 2
1. conditions of patients and its basic condition
27 years old B age of patient does not practise contraception more than 1 year, usually menstruation rule, health, once history of medical abortion, Previously there is colpomycosis;It is secondary sterility, vaginitis after diagnosing.
2. therapy
The Ovulatory decoction that preparation method of the present invention is obtained is pan-fried good spare, takes orally, and twice daily, getting up early is primary on an empty stomach, evening On sleep before half an hour take once;1 course for the treatment of of medication, totally 5 pairs.
Taking phase prohibits cold water wash up, drenches with rain, and prohibits the raw and cold food of food and drink, should not drink Aqua Folium Camelliae sinensis.
3. treatment results
Detection ovulation table after the tablet has been ingested, as shown in table 2:
2 patient B of table takes the monitoring ovulation table after 5 pairs of Ovulatory decoctions
From after drug administration 1 month, B ultrasound detects visible in utero pregnant bursa and early stage heart pipe beating/yolk bag, is diagnosed as morning It is pregnant.
Case 3
1. conditions of patients and its basic condition
25 years old C age of patient did not practised contraception more than 5 years, and menstruation usually is irregular, without dysmenorrhoea;Once there is polycystic ovary syndrome History;Tongue fur is thin, soft, side print with teeth, and arteries and veins is fine and smooth;The more folliculus samples of ultrasound diagnosis both ovaries change;Be after diagnosing primary sterility, Polycystic ovary syndrome.
2. therapy
The Ovulatory decoction that preparation method of the present invention is obtained is pan-fried good spare, takes orally, and twice daily, getting up early is primary on an empty stomach, evening On sleep before half an hour take once;2 courses for the treatment of of medication, first course for the treatment of 6 are paid;Second course for the treatment of 8 is paid, totally 14 pairs.
Taking phase prohibits cold water wash up, drenches with rain, and prohibits the raw and cold food of food and drink, should not drink Aqua Folium Camelliae sinensis.
3. treatment results
Detection ovulation table after the tablet has been ingested, as shown in table 3:
3 patient C of table takes the monitoring ovulation table after first course for the treatment of
From after taking medicine to the treatment for carrying out second course for the treatment of after menstrual onset, the ovulation situation of second course for the treatment of is as shown in table 4:
4 patient C of table takes the monitoring ovulation table after second course for the treatment of
From after two courses for the treatment of of drug administration, it is in utero pregnant that B ultrasound, which is detected, it is seen that plumule, yolk bag, pregnant heart pipe beating, really It examines as early pregnancy.
Four, embodiment
Embodiment 1
Step 1, weigh each component according to following mass fraction (every part of quality is 1g):18 parts of oriental wormwood, 18 parts of motherwort, river 12 parts of rhizome of chuanxiong, 12 parts of dipsacus root, 12 parts of HERBA EPIMEDII, 15 parts of Radix Rehmanniae, 12 parts of Semen Cuscutae, 12 parts of Radix Paeoniae Alba, 10 parts of Radix Angelicae Sinensis, 5 parts of Radix Glycyrrhizae;
Step 2, each component material mixing step 1 weighed, and obtained mixture is placed in marmite, add simultaneously Enter tap water and impregnates 0.5h;Wherein the volume of tap water is 300ml;
Step 3, by step 2, treated after mixture is boiled by fire, and conversion slow boiling decocts 30min, then filters, obtains Filter residue and first-time filtrate;
Step 4, tap water is continuously added in the filter residue of step 3, boils rear slow boiling and decocts 20min, then filtered, obtain Secondary filtrate;Wherein originally water volume is 200ml;
Step 5, it after the secondary filtrate of the first-time filtrate of step 3 and step 4 being mixed, filters again, obtained filtrate is i.e. For Ovulatory decoction.
Embodiment 2
Step 1, each component is weighed according to following mass fraction:19 parts of oriental wormwood, 20 parts of motherwort, 13 parts of Rhizoma Chuanxiong, dipsacus root 14 Part, 13 parts of HERBA EPIMEDII, 16 parts of Radix Rehmanniae, 14 parts of Semen Cuscutae, 13 parts of Radix Paeoniae Alba, 11 parts of Radix Angelicae Sinensis, 6 parts of Radix Glycyrrhizae;
Step 2, each component material mixing step 1 weighed, and obtained mixture is placed in marmite, add simultaneously Enter tap water and impregnates 35mim;Wherein the volume of tap water is not cross mixture 2cm;
Step 3, by step 2, treated after mixture is boiled by fire, and conversion slow boiling decocts 35min, then filters, obtains Filter residue and first-time filtrate;
Step 4, tap water is continuously added in the filter residue of step 3, boils rear slow boiling and decocts 24min, then filtered, obtain Secondary filtrate;Wherein originally water volume is not cross filter residue 1cm;
Step 5, it after the secondary filtrate of the first-time filtrate of step 3 and step 4 being mixed, filters again, obtained filtrate is i.e. For Ovulatory decoction.
Embodiment 3
Step 1, weigh each component according to following mass fraction (every part of quality is 1g):22 parts of oriental wormwood, 22 parts of motherwort, river 15 parts of rhizome of chuanxiong, 15 parts of dipsacus root, 15 parts of HERBA EPIMEDII, 16 parts of Radix Rehmanniae, 15 parts of Semen Cuscutae, 15 parts of Radix Paeoniae Alba, 13 parts of Radix Angelicae Sinensis, 8 parts of Radix Glycyrrhizae;
Step 2, each component material mixing step 1 weighed, and obtained mixture is placed in marmite, add simultaneously Enter tap water and impregnates 50min;Wherein the volume of tap water is 400ml;
Step 3, by step 2, treated after mixture is boiled by fire, and conversion slow boiling decocts 35min, then filters, obtains Filter residue and first-time filtrate;
Step 4, tap water is continuously added in the filter residue of step 3, boils rear slow boiling and decocts 25min, then filtered, obtain Secondary filtrate;Wherein originally water volume is 250ml;
Step 5, it after the secondary filtrate of the first-time filtrate of step 3 and step 4 being mixed, filters again, obtained filtrate is i.e. For Ovulatory decoction.
Embodiment 4
Step 1, each component is weighed according to following mass fraction:24 parts of oriental wormwood, 23 parts of motherwort, 17 parts of Rhizoma Chuanxiong, dipsacus root 16 Part, 17 parts of HERBA EPIMEDII, 17 parts of Radix Rehmanniae, 16 parts of Semen Cuscutae, 16 parts of Radix Paeoniae Alba, 14 parts of Radix Angelicae Sinensis, 8 parts of Radix Glycyrrhizae;
Step 2, each component material mixing step 1 weighed, and obtained mixture is placed in marmite, add simultaneously Enter tap water and impregnates 45min;Wherein the volume of tap water there was not mixture 3cm for 3
Step 3, by step 2, treated after mixture is boiled by fire, and conversion slow boiling decocts 38min, then filters, obtains Filter residue and first-time filtrate;
Step 4, tap water is continuously added in the filter residue of step 3, boils rear slow boiling and decocts 27min, then filtered, obtain Secondary filtrate;Wherein originally water volume is not cross filter residue 2cm;
Step 5, it after the secondary filtrate of the first-time filtrate of step 3 and step 4 being mixed, filters again, obtained filtrate is i.e. For Ovulatory decoction.
Embodiment 5
Step 1, weigh each component according to following mass fraction (every part of quality is 1g):25 parts of oriental wormwood, 25 parts of motherwort, river 18 parts of rhizome of chuanxiong, 18 parts of dipsacus root, 18 parts of HERBA EPIMEDII, 18 parts of Radix Rehmanniae, 18 parts of Semen Cuscutae, 18 parts of Radix Paeoniae Alba, 15 parts of Radix Angelicae Sinensis, 10 parts of Radix Glycyrrhizae;
Step 2, each component material mixing step 1 weighed, and obtained mixture is placed in marmite, add simultaneously Enter tap water and impregnates 1h;Wherein the volume of tap water is 500ml;
Step 3, by step 2, treated after mixture is boiled by fire, and conversion slow boiling decocts 40min, then filters, obtains Filter residue and first-time filtrate;
Step 4, tap water is continuously added in the filter residue of step 3, boils rear slow boiling and decocts 30min, then filtered, obtain Secondary filtrate;Wherein originally water volume is 300ml;
Step 5, it after the secondary filtrate of the first-time filtrate of step 3 and step 4 being mixed, filters again, obtained filtrate is i.e. For Ovulatory decoction.
Ovulatory decoction of the present invention has effects that the promoting flow of qi and blood circulation, controls women's infertility caused by female ovulation obstacle Therapeutic effect is apparent, and curative effect is stablized, and securely and reliably, therapeutic effect is good, and has no toxic side effect and adverse reaction.

Claims (7)

1. a kind of Ovulatory decoction, which is characterized in that include each component of following mass fraction:18-25 parts of oriental wormwood, motherwort 18- 25 parts, 12-18 parts of Rhizoma Chuanxiong, 12-18 parts of dipsacus root, 12-18 parts of HERBA EPIMEDII, 15-18 parts of Radix Rehmanniae, 12-18 parts of Semen Cuscutae, Radix Paeoniae Alba 12- 18 parts, 10-15 parts of Radix Angelicae Sinensis, 5-10 parts of Radix Glycyrrhizae.
2. a kind of preparation method of Ovulatory decoction, which is characterized in that include the following steps:
Step 1, each component is weighed according to following mass fraction:18-25 parts of oriental wormwood, 18-25 parts of motherwort, 12-18 parts of Rhizoma Chuanxiong, river Disconnected 12-18 parts, 12-18 parts of HERBA EPIMEDII, 15-18 parts of Radix Rehmanniae, 12-18 parts of Semen Cuscutae, 12-18 parts of Radix Paeoniae Alba, 10-15 parts of Radix Angelicae Sinensis is sweet It is 5-10 parts careless;
Step 2, each component material mixing step 1 weighed, and obtained mixture is placed in marmite, while being added certainly Water is impregnated;
Step 3, by step 2, treated after mixture is boiled by fire, and conversion slow boiling decocts, and then filters, obtains filter residue and one Secondary filtrate;
Step 4, tap water is continuously added in the filter residue of step 3, boils rear slow boiling and decocts, then filtered, obtain secondary filtrate;
Step 5, it after the secondary filtrate of the first-time filtrate of step 3 and step 4 being mixed, filters again, obtained filtrate is to promote Ovulation soup.
3. a kind of preparation method of Ovulatory decoction as claimed in claim 2, which is characterized in that tap water in the step 2 Volume is 300-500ml, or originally water volume there was not mixture 2-3cm.
4. a kind of preparation method for treating infertile Chinese medicine composition as claimed in claim 2, which is characterized in that described Soaking time is 0.5-1h in step 2.
5. a kind of preparation method for treating infertile Chinese medicine composition as claimed in claim 2, which is characterized in that described Slow boiling decocting time is 30-40min in step 3.
6. a kind of preparation method for treating infertile Chinese medicine composition as claimed in claim 2, which is characterized in that described The originally water volume being added in step 4 is 200-300ml, or originally water volume there was not filter residue 1-2cm.
7. a kind of preparation method for treating infertile Chinese medicine composition as claimed in claim 2, which is characterized in that described Slow boiling decocting time is 20-30min in step 4.
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