CN108472346A - 含有traf诱导结构域的嵌合受体及相关组合物和方法 - Google Patents

含有traf诱导结构域的嵌合受体及相关组合物和方法 Download PDF

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Publication number
CN108472346A
CN108472346A CN201680077930.4A CN201680077930A CN108472346A CN 108472346 A CN108472346 A CN 108472346A CN 201680077930 A CN201680077930 A CN 201680077930A CN 108472346 A CN108472346 A CN 108472346A
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cells
domain
cell
chimeric receptor
antigen
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Chinese (zh)
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L·J·汤普森
V·厄德高
B·萨瑟
A·布拉曼戴姆
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Juno Therapeutics Inc
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Juno Therapeutics Inc
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
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CN201680077930.4A 2015-11-05 2016-11-04 含有traf诱导结构域的嵌合受体及相关组合物和方法 Pending CN108472346A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562251590P 2015-11-05 2015-11-05
US62/251,590 2015-11-05
PCT/US2016/060736 WO2017079705A1 (en) 2015-11-05 2016-11-04 Chimeric receptors containing traf-inducing domains and related compositions and methods

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CN108472346A true CN108472346A (zh) 2018-08-31

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US (1) US20180319862A1 (https=)
EP (1) EP3370762A1 (https=)
JP (1) JP2018532432A (https=)
KR (1) KR20180082493A (https=)
CN (1) CN108472346A (https=)
AU (1) AU2016349724B2 (https=)
BR (1) BR112018008442A2 (https=)
CA (1) CA3002990A1 (https=)
MA (1) MA44314A (https=)
MX (1) MX2018005618A (https=)
WO (1) WO2017079705A1 (https=)

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CN111849910A (zh) * 2020-05-27 2020-10-30 南京北恒生物科技有限公司 工程化免疫细胞及其用途
CN112251452A (zh) * 2019-10-22 2021-01-22 上海斯丹赛生物技术有限公司 Til/tcr-t细胞治疗平台
CN113226359A (zh) * 2018-11-08 2021-08-06 耐克西缪恩有限公司 具有改进的表型特性的t细胞组合物
WO2021160120A1 (zh) * 2020-02-13 2021-08-19 北京艺妙神州医药科技有限公司 嵌合抗原受体的优化
CN113402612A (zh) * 2020-03-17 2021-09-17 西比曼生物科技（香港）有限公司 靶向cd19和cd20的联合嵌合抗原受体及其应用
WO2024140980A1 (zh) * 2022-12-30 2024-07-04 上药生物治疗（香港）有限公司 表达趋化因子受体的细胞及其用途
US12583903B2 (en) 2017-02-08 2026-03-24 AbelZeta Inc. Construction of chimeric antigen receptor targeting CD20 antigen and activity identification of engineered T cells thereof

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EP2948544A4 (en) 2013-01-28 2016-08-03 St Jude Childrens Res Hospital CHIMERIC RECEPTOR WITH NKG2D SPECIFICITY FOR CELL THERAPY AGAINST CANCER AND INFECTION DISEASES
DK3143134T3 (da) 2014-05-15 2021-01-04 Nat Univ Singapore Modificerede, naturlige dræberceller og anvendelser deraf
EP3234120B1 (en) 2014-12-15 2025-09-03 The Regents of the University of California Cytotoxic molecules responsive to intracellular ligands for selective t cell mediated killing
FI3240805T3 (fi) 2014-12-15 2025-02-17 Univ California Cd19- ja cd20-vasteellinen bispesifinen tai-veräjän kimeerinen antigeenireseptori
WO2016134371A2 (en) 2015-02-20 2016-08-25 Ohio State Innovation Foundation Bivalent antibody directed against nkg2d and tumor associated antigens
US11045543B2 (en) 2015-04-06 2021-06-29 Cytoimmune Therapeutics, Inc. EGFR-directed car therapy for glioblastoma
PL3368571T3 (pl) 2015-10-30 2023-05-02 The Regents Of The University Of California Polipeptydy odpowiadające na transformujący czynnik wzrostu beta i sposoby ich zastosowania
AU2017335634A1 (en) 2016-09-27 2019-03-14 Cero Therapeutics, Inc. Chimeric engulfment receptor molecules
EP3567049A4 (en) 2016-12-28 2020-08-26 Green Cross Lab Cell Corporation CHEMERICAL ANTIGENIC RECEPTOR AND NATURAL KILLER CELLS EXPRESSING THE SAME
BR112019019917A2 (pt) 2017-03-27 2020-04-22 Nat Univ Singapore receptores quiméricos nkg2d truncados e seus usos em imunoterapia de células exterminadoras naturais
CA3056591A1 (en) 2017-03-27 2018-10-04 National University Of Singapore Stimulatory cell lines for ex vivo expansion and activation of natural killer cells
CN107177632B (zh) * 2017-05-27 2020-02-07 上海优卡迪生物医药科技有限公司 一种基于octs技术的髓系白血病car-t治疗载体及其构建方法和应用
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