CN1084613C - 气雾剂 - Google Patents
气雾剂 Download PDFInfo
- Publication number
- CN1084613C CN1084613C CN96198984A CN96198984A CN1084613C CN 1084613 C CN1084613 C CN 1084613C CN 96198984 A CN96198984 A CN 96198984A CN 96198984 A CN96198984 A CN 96198984A CN 1084613 C CN1084613 C CN 1084613C
- Authority
- CN
- China
- Prior art keywords
- alcohol
- weight
- aerosol
- stock solution
- liquefied gas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000443 aerosol Substances 0.000 title claims abstract description 42
- 238000002360 preparation method Methods 0.000 title abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 56
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000003380 propellant Substances 0.000 claims abstract description 5
- 239000011550 stock solution Substances 0.000 claims description 24
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 17
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 12
- -1 spermol Chemical compound 0.000 claims description 9
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 8
- 229910052799 carbon Inorganic materials 0.000 claims description 8
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 7
- 239000004166 Lanolin Substances 0.000 claims description 4
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 claims description 4
- 235000019388 lanolin Nutrition 0.000 claims description 4
- 229940039717 lanolin Drugs 0.000 claims description 4
- 229940081733 cetearyl alcohol Drugs 0.000 claims description 2
- 229960000735 docosanol Drugs 0.000 claims description 2
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 claims description 2
- 229940012831 stearyl alcohol Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 12
- 238000001816 cooling Methods 0.000 abstract description 10
- 238000000034 method Methods 0.000 abstract description 6
- 208000003251 Pruritus Diseases 0.000 abstract description 5
- 208000002193 Pain Diseases 0.000 abstract description 4
- 230000036407 pain Effects 0.000 abstract description 4
- 230000001804 emulsifying effect Effects 0.000 abstract description 3
- 239000007787 solid Substances 0.000 abstract description 3
- 208000034656 Contusions Diseases 0.000 abstract description 2
- 208000006877 Insect Bites and Stings Diseases 0.000 abstract description 2
- 206010024453 Ligament sprain Diseases 0.000 abstract description 2
- 208000010040 Sprains and Strains Diseases 0.000 abstract description 2
- 230000009519 contusion Effects 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 201000004647 tinea pedis Diseases 0.000 abstract description 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 239000012141 concentrate Substances 0.000 abstract 1
- 230000003387 muscular Effects 0.000 abstract 1
- BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 abstract 1
- 235000019441 ethanol Nutrition 0.000 description 33
- 230000000052 comparative effect Effects 0.000 description 13
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 12
- 239000007789 gas Substances 0.000 description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 7
- 238000005507 spraying Methods 0.000 description 7
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 6
- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 description 5
- 229940031578 diisopropyl adipate Drugs 0.000 description 5
- 238000004090 dissolution Methods 0.000 description 5
- 229960000905 indomethacin Drugs 0.000 description 5
- 239000008213 purified water Substances 0.000 description 5
- 239000007921 spray Substances 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 4
- 150000005215 alkyl ethers Chemical class 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- MCCACAIVAXEFAL-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole;nitric acid Chemical compound O[N+]([O-])=O.ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 MCCACAIVAXEFAL-UHFFFAOYSA-N 0.000 description 3
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000004945 emulsification Methods 0.000 description 3
- 230000002045 lasting effect Effects 0.000 description 3
- 229960005040 miconazole nitrate Drugs 0.000 description 3
- 230000002085 persistent effect Effects 0.000 description 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- ZEMPKEQAKRGZGQ-AAKVHIHISA-N 2,3-bis[[(z)-12-hydroxyoctadec-9-enoyl]oxy]propyl (z)-12-hydroxyoctadec-9-enoate Chemical class CCCCCCC(O)C\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CC(O)CCCCCC)COC(=O)CCCCCCC\C=C/CC(O)CCCCCC ZEMPKEQAKRGZGQ-AAKVHIHISA-N 0.000 description 2
- LVYLCBNXHHHPSB-UHFFFAOYSA-N 2-hydroxyethyl salicylate Chemical compound OCCOC(=O)C1=CC=CC=C1O LVYLCBNXHHHPSB-UHFFFAOYSA-N 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 230000000254 damaging effect Effects 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000001282 iso-butane Substances 0.000 description 2
- 235000013847 iso-butane Nutrition 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 2
- IZUPBVBPLAPZRR-UHFFFAOYSA-N pentachlorophenol Chemical compound OC1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1Cl IZUPBVBPLAPZRR-UHFFFAOYSA-N 0.000 description 2
- 239000001294 propane Substances 0.000 description 2
- 235000013849 propane Nutrition 0.000 description 2
- IJDNQMDRQITEOD-UHFFFAOYSA-N sec-butylidene Natural products CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 2
- MQHLMHIZUIDKOO-OKZBNKHCSA-N (2R,6S)-2,6-dimethyl-4-[(2S)-2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine Chemical compound C1=CC(C(C)(C)CC)=CC=C1C[C@H](C)CN1C[C@@H](C)O[C@@H](C)C1 MQHLMHIZUIDKOO-OKZBNKHCSA-N 0.000 description 1
- YCIHPQHVWDULOY-FMZCEJRJSA-N (4s,4as,5as,6s,12ar)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;hydrochloride Chemical compound Cl.C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]4(O)C(=O)C3=C(O)C2=C1O YCIHPQHVWDULOY-FMZCEJRJSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- OCAPBUJLXMYKEJ-UHFFFAOYSA-N 1-[biphenyl-4-yl(phenyl)methyl]imidazole Chemical compound C1=NC=CN1C(C=1C=CC(=CC=1)C=1C=CC=CC=1)C1=CC=CC=C1 OCAPBUJLXMYKEJ-UHFFFAOYSA-N 0.000 description 1
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 description 1
- FRPZMMHWLSIFAZ-UHFFFAOYSA-N 10-undecenoic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 description 1
- ZJRHNNNACBPWEB-UHFFFAOYSA-N 2-[2-(dimethylamino)ethoxy]ethyl phenothiazine-10-carboxylate;hydron;chloride Chemical compound Cl.C1=CC=C2N(C(=O)OCCOCCN(C)C)C3=CC=CC=C3SC2=C1 ZJRHNNNACBPWEB-UHFFFAOYSA-N 0.000 description 1
- SPCKHVPPRJWQRZ-UHFFFAOYSA-N 2-benzhydryloxy-n,n-dimethylethanamine;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 SPCKHVPPRJWQRZ-UHFFFAOYSA-N 0.000 description 1
- XMIIGOLPHOKFCH-UHFFFAOYSA-N 3-phenylpropionic acid Chemical compound OC(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-N 0.000 description 1
- PJJGZPJJTHBVMX-UHFFFAOYSA-N 5,7-Dihydroxyisoflavone Chemical compound C=1C(O)=CC(O)=C(C2=O)C=1OC=C2C1=CC=CC=C1 PJJGZPJJTHBVMX-UHFFFAOYSA-N 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- AKUJBENLRBOFTD-RPRRAYFGSA-N Dexamethasone acetate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)COC(C)=O)(O)[C@@]1(C)C[C@@H]2O AKUJBENLRBOFTD-RPRRAYFGSA-N 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- ZRTQSJFIDWNVJW-WYMLVPIESA-N Lanoconazole Chemical compound ClC1=CC=CC=C1C(CS\1)SC/1=C(\C#N)N1C=NC=C1 ZRTQSJFIDWNVJW-WYMLVPIESA-N 0.000 description 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
- 206010049565 Muscle fatigue Diseases 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- 229930193140 Neomycin Natural products 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- CRKGMGQUHDNAPB-UHFFFAOYSA-N Sulconazole nitrate Chemical compound O[N+]([O-])=O.C1=CC(Cl)=CC=C1CSC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 CRKGMGQUHDNAPB-UHFFFAOYSA-N 0.000 description 1
- 208000002474 Tinea Diseases 0.000 description 1
- 241000130764 Tinea Species 0.000 description 1
- IJCWFDPJFXGQBN-RYNSOKOISA-N [(2R)-2-[(2R,3R,4S)-4-hydroxy-3-octadecanoyloxyoxolan-2-yl]-2-octadecanoyloxyethyl] octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCCCCCCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCCCCCCCCCCCC IJCWFDPJFXGQBN-RYNSOKOISA-N 0.000 description 1
- 239000003655 absorption accelerator Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 150000007933 aliphatic carboxylic acids Chemical class 0.000 description 1
- 229960003204 amorolfine Drugs 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 229960002206 bifonazole Drugs 0.000 description 1
- 235000013844 butane Nutrition 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 229940025250 camphora Drugs 0.000 description 1
- 239000010238 camphora Substances 0.000 description 1
- KHAVLLBUVKBTBG-UHFFFAOYSA-N caproleic acid Natural products OC(=O)CCCCCCCC=C KHAVLLBUVKBTBG-UHFFFAOYSA-N 0.000 description 1
- 229940082500 cetostearyl alcohol Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- IVHBBMHQKZBJEU-UHFFFAOYSA-N cinchocaine hydrochloride Chemical compound [Cl-].C1=CC=CC2=NC(OCCCC)=CC(C(=O)NCC[NH+](CC)CC)=C21 IVHBBMHQKZBJEU-UHFFFAOYSA-N 0.000 description 1
- 229960004022 clotrimazole Drugs 0.000 description 1
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 description 1
- DNTGGZPQPQTDQF-XBXARRHUSA-N crotamiton Chemical compound C/C=C/C(=O)N(CC)C1=CC=CC=C1C DNTGGZPQPQTDQF-XBXARRHUSA-N 0.000 description 1
- 229960003338 crotamiton Drugs 0.000 description 1
- 229940045574 dibucaine hydrochloride Drugs 0.000 description 1
- 229960001259 diclofenac Drugs 0.000 description 1
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 description 1
- 229960002002 dimethoxanate hydrochloride Drugs 0.000 description 1
- 229960000520 diphenhydramine Drugs 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- CIKWKGFPFXJVGW-UHFFFAOYSA-N ethacridine Chemical compound C1=C(N)C=CC2=C(N)C3=CC(OCC)=CC=C3N=C21 CIKWKGFPFXJVGW-UHFFFAOYSA-N 0.000 description 1
- 229960001588 ethacridine Drugs 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 229960002390 flurbiprofen Drugs 0.000 description 1
- SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 238000002309 gasification Methods 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 229960002389 glycol salicylate Drugs 0.000 description 1
- IDWJWYPAJJDASX-GKXBZDASSA-N hachimycin Chemical compound O1C(=O)CC(=O)CC(O)CC(O)CCCC(O)CC(O)CC(O2)(O)CC(O)C(C(O)=O)C2CC(OC2C(C(N)C(O)C(C)O2)O)\C=C/C=C\C=C\C=C/C=C\C=C\C=C\C(C)C1C(C)CCC(O)CC(=O)C1=CC=C(N)C=C1 IDWJWYPAJJDASX-GKXBZDASSA-N 0.000 description 1
- 229960003372 hachimycin Drugs 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 229940074928 isopropyl myristate Drugs 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
- 229960000318 kanamycin Drugs 0.000 description 1
- 229930027917 kanamycin Natural products 0.000 description 1
- 229930182823 kanamycin A Natural products 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229950010163 lanoconazole Drugs 0.000 description 1
- 229960004194 lidocaine Drugs 0.000 description 1
- 239000003915 liquefied petroleum gas Substances 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 229960003464 mefenamic acid Drugs 0.000 description 1
- 229960001047 methyl salicylate Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229960004927 neomycin Drugs 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 229960003483 oxiconazole Drugs 0.000 description 1
- QRJJEGAJXVEBNE-MOHJPFBDSA-N oxiconazole Chemical compound ClC1=CC(Cl)=CC=C1CO\N=C(C=1C(=CC(Cl)=CC=1)Cl)\CN1C=NC=C1 QRJJEGAJXVEBNE-MOHJPFBDSA-N 0.000 description 1
- 150000002960 penicillins Chemical class 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 229960002702 piroxicam Drugs 0.000 description 1
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 230000032361 posttranscriptional gene silencing Effects 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 239000001589 sorbitan tristearate Substances 0.000 description 1
- 235000011078 sorbitan tristearate Nutrition 0.000 description 1
- 229960004129 sorbitan tristearate Drugs 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 229960004718 sulconazole nitrate Drugs 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/122—Foams; Dry foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/24—Thermal properties
- A61K2800/244—Endothermic; Cooling; Cooling sensation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Dispersion Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
一种气雾剂，其组成为一种含有C1-3醇和C12以上醇的基液以及一种含有液化气的喷射剂，而且能给出凝固成冰果汁状的喷出物。在生产该制剂时，可以掺入对水不稳定的组分，无需任何复杂的乳化程序。它有持久的冷却效果。因此，它能有效地迅速缓解由挫伤、扭伤、肌肉疲劳等引起的疼痛，或由足癣、虫咬等引起的骚痒。
Description
技术领域
本发明涉及一种喷射时喷出物在喷射部凝固成冰果汁状、冷却效果高的气雾剂。
背景技术
为了使挫伤、扭伤、肌肉疲劳等引起的疼痛或足癣、虫咬等引起的发痒迅速镇定下来，使患部冷却的做法是有效的。以往对这些症状往往使用以雾状喷出的气雾剂。然而，由于以雾状喷出的气雾剂对皮肤的冷却效果没有持续性，因而喷出物不能达到使患部的疼痛、发痒持久镇定的效果。作为解决这一缺点的办法，WO 90/11068号公报说明书、特开平4-103526号公报等公开了喷射物能形成冰果汁状泡沫凝胶的气雾剂。但是，先有技术上已知的气雾剂制造时需要使原液加温、乳化来配制这样复杂的操作，制造效率低下，是成问题的。
此外，先有技术上已知的。喷射物凝固成冰果汁状的气雾剂，由于是通过使配合的水冷冻达到持久冷却效果的，因而必须有水的配合，使得在水中不稳定的药剂或亲油性高的药剂难以配合。
发明公开
为了解决上述问题，本发明者等人反复进行深入研究的结果，发现由低级醇、高级醇和液化气配合而成的气雾剂制造时不需要乳化操作，而且喷射时喷出物凝固成冰果汁状，因而有持久的冷却效果，从而完成本发明。
即，本发明是由含有1～3个碳的低级醇和12个碳以上的高级醇的原液以及含有液化气的喷射剂组成的、喷射物凝固成冰果汁状的气雾剂。
先有技术上已知的、喷出物会凝固的气雾剂，全都是借助于使配合的水冷冻而使喷出物凝固的，但本发明的气雾剂不一定必须有水的配合，其特征在于在全新的条件下使喷出物凝固。
本发明的气雾剂，是使被液化气的气化热冷却的高级醇连同低级醇一起凝固而变成冰果汁状的。
本发明中1～3个碳的低级醇，系指直链状或支链状的醇，具体地可以列举甲醇、乙醇、改性乙醇、丙醇、异丙醇等，但尤其好的可以列举乙醇。低级醇的配合量，较好的是制剂总量的0.3～65％(重量)、更好的是1.5～50％(重量)、最好的是15～35％(重量)。低级醇的配合量若不足0.3％(重量)则原液与喷射剂难以均匀混合，而若超过65％(重量)则由于喷射剂量相对减少而变得没有冷感。
本发明中12个碳以上的高级醇系指直链状或支链状的醇，是必须能与其它配合成分混合而成为均一体系者。具体地说，可以列举月桂醇、鲸蜡醇、硬脂醇、鲸蜡硬脂醇(cetostearyl alcohol)、山萮醇、羊毛脂醇、氢化羊毛脂醇等的纯品或混合物，尤其好的可以列举硬脂醇或鲸蜡醇。
高级醇的配合量，较好的是制剂总量的0.005～14％(重量)、更好的是0.015～10％(重量)、最好的是0.5～5％(重量)。高级醇的配合量若不足0.005％(重量)则喷出物难以凝固，因而持续冷感变弱。而若超过14％(重量)则高级醇难以溶解，因而制造变得繁杂。
高级醇若不能被低级醇和液化气完全溶解而成为均一体系，就不能达到本发明的效果。因此，高级醇溶解不充分时也可以配合其它溶剂、溶解助剂(聚氧乙烯烷基醚、聚氧乙烯氢化蓖麻油、己二酸二异丙酯、肉豆蔻酸异丙酯、1，3-丁二醇、丙二醇、聚乙二醇、甘油、乳酸、氢氧化钠等)等。
液化气只要是在通常气雾剂中可以作为喷射剂使用的即可，但较好的可以列举二甲醚、正丁烷、异丁烷、丙烷、液化石油气等的纯品或混合物。液化气的配合量较好的是制剂总量的30～95％(重量)、更好的是50～85％(重量)。液化气的配合量若不足30％(重量)则气雾剂的冷感降低，对疼痛、骚痒的镇定效果变弱。而液化剂的配合量若超过95％(重量)，则气雾剂的喷射性状就成为雾状，难以达到持久的冷却效果。
本发明的气雾剂若考虑把凝固成冰果汁状的条件区分为气雾剂原液和液化气，则1～3个碳的低级醇在原液中的配比必须在6％(重量)以上，12个碳以上的高级醇在原液中的配比必须在1％(重量)以上，相对于原液1重量份而言，液化气的量必须是0.5～20重量份。
本发明的气雾剂可以通过使低级醇与高级醇溶解而成为均一体系，必要时进一步配合不破坏均一体系的其它成分，由此得到的原液连同液化气一起灌装到气雾剂容器中来制造。作为气雾剂容器，可以用通常使用的金属制或塑料制的容器。从冷却效果的持久性观点来看，作为不破坏均一体系的其它成分，若配合适量的水则更好。若原液中配合了水，则配合量可以在原液总量的90％(重量)以下，但从制剂设计的容易性观点来看，在原液中的配合量较好在20～60％(重量)。
本发明的气雾剂，为了增进患部的镇痛、止痒效果，可以在不损害本发明效果的限度内配合消炎镇痛剂(消炎痛，水杨酸甲酯，水杨酸乙二醇酯，酮苯丙酸，氟联苯丙酸，吡罗昔康，双氯芬酸，布洛芬，甲灭酸，乙酸氟美松等)，止痒剂(克罗他米通、鱼石脂，mochthamol，麝香草脑酸等)，抗真菌剂(盐酸阿莫罗芬，十一烯酸，五氯苯酚，克霉唑，癣退，曲古霉素，双氯苯咪唑硝酸盐，lanoconazole，硝酸硫康唑，oxyconazole硝酸盐，联苯苄唑等)，抗组胺剂(苯海拉明，盐酸苯海拉明，盐酸氮异丙嗪等)，局部麻醉剂(利多卡因，盐酸狄布卡因等)，抗菌剂(碘化钾，葡糖酸洗必泰，利凡诺，氯化苯甲烃铵等)，抗化脓性疾患剂(青霉素类、盐酸四环素，新霉素，卡那霉素等)，清凉剂(1-薄荷脑，樟脑，薄荷油等)等药效成分。药效成分的配合量因成分而异，较好的是制剂总量的0.001～10％(重量)。
本发明的气雾剂必要时也可以在不损害本发明效果的限度内配合抗氧剂(二丁基羟基甲苯等)，经皮吸收促进剂(甘油脂肪酸酯，油脂类，脂肪族羧酸酯，烟酸酯，azone，烷二醇脂肪酸酯等)，香料、染料等气雾剂中通常使用的添加剂。
产业上利用的可能性
按照本发明制造时不需要繁杂的乳化操作，且具有与先有技术产品同样的冷却效果，使其喷出物能凝固成冰果汁状的气雾剂的提供成为可能。
发明的最佳实施形态
以下用实施例和试验例更详细地说明本发明。
实施例1
硬脂醇4.76重量份与乙醇28.53重量份混合、搅拌，配制成均匀溶解的原液。这种原液灌装到耐压容器中，装上阀门，然后灌装丙烷0.07重量份、正丁烷1.93份、异丁烷0.93重量份和二甲醚63.78重量份。装上喷雾用喷嘴，就制成了气雾剂。
实施例2
消炎痛(抗炎吲哚酸)0.31重量份、己二酸二异丙酯4.11重量份、聚氧乙烯烷基醚1.23重量份、变性乙醇16.47重量份、精制水13.39重量份和鲸蜡醇1.23重量份混合、搅拌、均匀溶解，调制成原液。把该原液灌装到耐压容器中，装上阀门，再灌装二甲醚63.26重量份。装上喷雾用喷嘴，就得到了气雾剂。
实施例3
双氯苯咪唑硝酸盐0.35重量份、己二酸二异丙酯1.76重量份、肉豆蔻酸异丙酯1.05重量份、甘油0.70重量份、变性乙醇15.80重量份、精制水8.74重量份、硬脂醇0.53重量份、鲸蜡醇0.53重量份、聚氧乙烯烷基醚0.70重量份和聚氧乙烯氢化蓖麻油0.35重量份混合、搅拌、均匀溶解，调制成原液。把该原液灌装到耐压容器中，装上阀门，再灌装二甲醚69.49重量份，装上喷雾用喷嘴，就得到了气雾剂。
比较例1
用实施例1的硬脂醇改变成乙醇的处方，按照与实施例1同样的方法，得到了气雾剂。
比较例2
用实施例2的聚氧乙烯烷基醚改变成变性乙醇、鲸蜡醇改变成精制水的处方，按照与实施例2同样的方法，得到了比较用的气雾剂。
比较例3
双氯苯咪唑硝酸盐0.36重量份、己二酸二异丙酯1.79重量份、肉豆蔻酸异丙酯1.07重量份、甘油0.71重量份、变性乙醇17.06重量份和精制水8.27重量份混合、搅拌、均匀溶解，调制成原液。把该原液灌装到耐压容器中，装上阀门，再灌装二甲醚70.74重量份。装上喷雾用喷嘴，得到了比较用的气雾剂。
比较例4(制造时需要乳化作业的气雾剂)
消炎痛(抗炎吲哚酸)0.31重量份、己二酸二异丙酯4.07重量份、聚氧乙烯脱水山梨醇单硬脂酸酯1.22重量份、聚氧乙烯脱水山梨醇三硬脂酸酯0.81重量份和脱水山梨醇单硬脂酸酯1.22重量份加温、熔融后，添加温精制水15.94重量份，充分混合。进一步边搅拌边冷却后，加入变性乙醇14.23重量份，均匀分散，调制成原液。该原液灌装到耐压容器中，装上阀门，再灌装二甲醚62.20重量份。装上喷雾用喷嘴，制成气雾剂。
试验例1
在设定于33℃的恒温水槽上，放置一块用胶带固定了热电偶传感器的薄板，对热电偶传感器分别喷涂3秒钟实施例1～3和比较例1～4的气雾剂。确认喷出物的性状，测定热电偶传感器显示值随时间的变化。结果列于表1中。
表1
| 样品 | 乳化操作 | 冰果汁状物 | 热电偶传感器的温度变化(℃) | |||||||
| 喷射前 | 15秒 | 30秒 | 45秒 | 60秒 | 90秒 | 120秒 | 180秒 | |||
| 实施例1实施例2实施例3比较例1比较例2比较例3比较例4 | 不要不要不要不要不要不要要 | 形成形成形成未形成未形成未形成形成 | 33.533.533.233.333.333.433.3 | 18.414.815.030.933.022.015.8 | 20.815.314.731.930.531.915.5 | 21.518.815.632.032.532.118.9 | 23.523.520.232.432.932.423.0 | 24.626.122.932.633.032.931.2 | 30.729.331.633.233.333.031.2 | 33.031.532.933.233.233.333.0 |
实施例1～3和比较例4的喷出物形成了冰果汁状固形物，但比较例1～3不形成冰果汁状固形物。而且，即使在热电偶传感器的温度变化方面，比较例1～3也在喷射30秒后就达到30℃以上，45秒后就回到差不多原来的温度，相对而言，发现实施例1-3和比较例4有持久的冷却效果。
Claims (6)
1.喷出物能凝固成冰果汁状的气雾剂，其中包含占总重量0.3～65％的1～3个碳的低级醇和占重量0.005～14％的至少一种选自月桂醇、鲸蜡醇、硬脂醇、鲸蜡硬脂醇、山萮醇、羊毛脂醇和氢化羊毛脂醇的高级醇的原液，以及占总重量30～95％液化气喷射剂。
2.权利要求1所述的气雾剂，其中，1～3个碳的低级醇占6％(重量)以上，高级醇占1％(重量)以上，相对于原液1重量份而言，液化气为0.5～20重量份。
3.权利要求1或2所述的气雾剂，其中低级醇是乙醇。
4.权利要求1或2所述的气雾剂，其中高级醇是硬脂醇和鲸蜡醇中至少一种。
5.权利要求1或2所述的气雾剂，其中还包含水。
6.权利要求5所述的气雾剂，其中水的配合量是原液的20～60％(重量)。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP32533595 | 1995-12-14 | ||
| JP325335/95 | 1995-12-14 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN01119505A Division CN1326730A (zh) | 1995-12-14 | 2001-05-22 | 气雾剂 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1204256A CN1204256A (zh) | 1999-01-06 |
| CN1084613C true CN1084613C (zh) | 2002-05-15 |
Family
ID=18175665
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96198984A Expired - Fee Related CN1084613C (zh) | 1995-12-14 | 1996-12-12 | 气雾剂 |
| CN01119505A Pending CN1326730A (zh) | 1995-12-14 | 2001-05-22 | 气雾剂 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN01119505A Pending CN1326730A (zh) | 1995-12-14 | 2001-05-22 | 气雾剂 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6133327A (zh) |
| EP (1) | EP0870497B1 (zh) |
| KR (1) | KR100450861B1 (zh) |
| CN (2) | CN1084613C (zh) |
| AT (1) | ATE263546T1 (zh) |
| AU (1) | AU705038B2 (zh) |
| DE (1) | DE69632148T2 (zh) |
| DK (1) | DK0870497T3 (zh) |
| ES (1) | ES2217334T3 (zh) |
| HK (1) | HK1040370A1 (zh) |
| NZ (1) | NZ330679A (zh) |
| WO (1) | WO1997021426A1 (zh) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7645442B2 (en) | 2001-05-24 | 2010-01-12 | Alexza Pharmaceuticals, Inc. | Rapid-heating drug delivery article and method of use |
| US7458374B2 (en) | 2002-05-13 | 2008-12-02 | Alexza Pharmaceuticals, Inc. | Method and apparatus for vaporizing a compound |
| US7766013B2 (en) | 2001-06-05 | 2010-08-03 | Alexza Pharmaceuticals, Inc. | Aerosol generating method and device |
| EP1392258B1 (en) * | 2001-05-24 | 2008-11-26 | Alexza Pharmaceuticals, Inc. | Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route |
| US6737042B2 (en) | 2001-05-24 | 2004-05-18 | Alexza Molecular Delivery Corporation | Delivery of drug esters through an inhalation route |
| US20070122353A1 (en) | 2001-05-24 | 2007-05-31 | Hale Ron L | Drug condensation aerosols and kits |
| IL152486A0 (en) | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
| US20080138296A1 (en) | 2002-10-25 | 2008-06-12 | Foamix Ltd. | Foam prepared from nanoemulsions and uses |
| US7700076B2 (en) | 2002-10-25 | 2010-04-20 | Foamix, Ltd. | Penetrating pharmaceutical foam |
| US7704518B2 (en) | 2003-08-04 | 2010-04-27 | Foamix, Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
| BR0314916A (pt) | 2002-10-25 | 2005-08-16 | Foamix Ltd | Espuma farmacêutica e cosmética |
| US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
| US9668972B2 (en) | 2002-10-25 | 2017-06-06 | Foamix Pharmaceuticals Ltd. | Nonsteroidal immunomodulating kit and composition and uses thereof |
| US10117812B2 (en) | 2002-10-25 | 2018-11-06 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
| KR20020089279A (ko) * | 2002-11-06 | 2002-11-29 | 전상문 | 운데실렌산 용액 |
| US20040105818A1 (en) | 2002-11-26 | 2004-06-03 | Alexza Molecular Delivery Corporation | Diuretic aerosols and methods of making and using them |
| US7913688B2 (en) | 2002-11-27 | 2011-03-29 | Alexza Pharmaceuticals, Inc. | Inhalation device for producing a drug aerosol |
| EP1625333A1 (en) | 2003-05-21 | 2006-02-15 | Alexza Pharmaceuticals, Inc. | Self-contained heating unit and drug-supply unit employing same |
| EP1637132B1 (en) | 2003-06-25 | 2010-10-06 | Hisamitsu Pharmaceutical Co., Inc. | External preparation for athlete´s foot treatment |
| US7540286B2 (en) | 2004-06-03 | 2009-06-02 | Alexza Pharmaceuticals, Inc. | Multiple dose condensation aerosol devices and methods of forming condensation aerosols |
| US20080260655A1 (en) | 2006-11-14 | 2008-10-23 | Dov Tamarkin | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
| US20080216828A1 (en) | 2007-03-09 | 2008-09-11 | Alexza Pharmaceuticals, Inc. | Heating unit for use in a drug delivery device |
| US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
| WO2009069006A2 (en) | 2007-11-30 | 2009-06-04 | Foamix Ltd. | Foam containing benzoyl peroxide |
| WO2009090495A2 (en) | 2007-12-07 | 2009-07-23 | Foamix Ltd. | Oil and liquid silicone foamable carriers and formulations |
| US20120087872A1 (en) | 2009-04-28 | 2012-04-12 | Foamix Ltd. | Foamable Vehicles and Pharmaceutical Compositions Comprising Aprotic Polar Solvents and Uses Thereof |
| CA2769677A1 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses |
| WO2011013009A2 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses |
| WO2011039638A2 (en) | 2009-10-02 | 2011-04-07 | Foamix Ltd. | Topical tetracycline compositions |
| US9849142B2 (en) | 2009-10-02 | 2017-12-26 | Foamix Pharmaceuticals Ltd. | Methods for accelerated return of skin integrity and for the treatment of impetigo |
| AT513312A1 (de) * | 2012-08-17 | 2014-03-15 | Gebro Holding Gmbh | Antiseptische Zusammensetzung |
| US10398641B2 (en) | 2016-09-08 | 2019-09-03 | Foamix Pharmaceuticals Ltd. | Compositions and methods for treating rosacea and acne |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5397564A (en) * | 1989-03-17 | 1995-03-14 | Taisho Pharmaceutical Co., Ltd. | Aerosol preparation for external use |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3584115A (en) * | 1968-05-31 | 1971-06-08 | Arthur Ira Gebhart | Method of applying visible aerosol compositions |
| DE3311700A1 (de) * | 1983-03-30 | 1984-10-04 | Bayer Ag | Antimykotische mittel mit hoher wirkstoff-freisetzung in form von loesung und spray |
| US4495169A (en) * | 1983-08-22 | 1985-01-22 | Basf Wyandotte Corporation | Aerosol gel shaving cream |
| ATE71295T1 (de) * | 1983-10-24 | 1992-01-15 | Lockley Services Pty Ltd | Schaumbare biozidezusammensetzung. |
| US4588581A (en) * | 1984-11-16 | 1986-05-13 | Basf Corporation | Methods and compositions for intravaginal contraception |
| US5143717A (en) * | 1987-12-30 | 1992-09-01 | Code Blue Medical Corporation | Burn foam and delivery system |
| JP2960445B2 (ja) * | 1988-12-28 | 1999-10-06 | 株式会社大阪造船所 | エアゾール用組成物 |
| US5209921A (en) * | 1989-05-19 | 1993-05-11 | Beecham Group Plc | Aerosol compositions |
| ATE124860T1 (de) * | 1989-07-28 | 1995-07-15 | Hisamitsu Pharmaceutical Co | Schaumaerosolzusammensetzung. |
| JP3038837B2 (ja) * | 1990-08-21 | 2000-05-08 | 大正製薬株式会社 | 皮膚冷却エアゾール剤 |
| CN1106259A (zh) * | 1994-02-05 | 1995-08-09 | 日东制药株式会社 | 含有作为有效成分的丙酸类非类固醇性药物的新颖消炎镇痛外用凝胶制剂 |
-
1996
- 1996-12-12 ES ES96941849T patent/ES2217334T3/es not_active Expired - Lifetime
- 1996-12-12 CN CN96198984A patent/CN1084613C/zh not_active Expired - Fee Related
- 1996-12-12 AT AT96941849T patent/ATE263546T1/de not_active IP Right Cessation
- 1996-12-12 DK DK96941849T patent/DK0870497T3/da active
- 1996-12-12 NZ NZ330679A patent/NZ330679A/xx unknown
- 1996-12-12 KR KR10-1998-0704462A patent/KR100450861B1/ko not_active IP Right Cessation
- 1996-12-12 WO PCT/JP1996/003631 patent/WO1997021426A1/ja active IP Right Grant
- 1996-12-12 US US09/091,101 patent/US6133327A/en not_active Expired - Fee Related
- 1996-12-12 DE DE69632148T patent/DE69632148T2/de not_active Expired - Fee Related
- 1996-12-12 AU AU11103/97A patent/AU705038B2/en not_active Ceased
- 1996-12-12 EP EP96941849A patent/EP0870497B1/en not_active Expired - Lifetime
-
2001
- 2001-05-22 CN CN01119505A patent/CN1326730A/zh active Pending
-
2002
- 2002-03-11 HK HK02101844.4A patent/HK1040370A1/zh unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5397564A (en) * | 1989-03-17 | 1995-03-14 | Taisho Pharmaceutical Co., Ltd. | Aerosol preparation for external use |
Also Published As
| Publication number | Publication date |
|---|---|
| DE69632148T2 (de) | 2005-03-17 |
| US6133327A (en) | 2000-10-17 |
| HK1040370A1 (zh) | 2002-06-07 |
| CN1326730A (zh) | 2001-12-19 |
| EP0870497B1 (en) | 2004-04-07 |
| EP0870497A1 (en) | 1998-10-14 |
| ATE263546T1 (de) | 2004-04-15 |
| NZ330679A (en) | 2000-03-27 |
| DK0870497T3 (da) | 2004-05-24 |
| WO1997021426A1 (fr) | 1997-06-19 |
| KR19990072131A (ko) | 1999-09-27 |
| KR100450861B1 (ko) | 2005-03-16 |
| ES2217334T3 (es) | 2004-11-01 |
| AU1110397A (en) | 1997-07-03 |
| DE69632148D1 (de) | 2004-05-13 |
| CN1204256A (zh) | 1999-01-06 |
| AU705038B2 (en) | 1999-05-13 |
| EP0870497A4 (en) | 1999-03-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1084613C (zh) | 气雾剂 | |
| US6214318B1 (en) | Aerosol ointment compositions for topical use | |
| US8518376B2 (en) | Oil-based foamable carriers and formulations | |
| DK2579852T3 (en) | PHARMACEUTICAL SPRAY COMPOSITION INCLUDING AN ANALOG OF VITAMIN D AND a corticosteroid | |
| CA2293622C (en) | Aerosol preparation | |
| US20140050673A1 (en) | Oil-Based Foamable Carriers And Formulations | |
| WO2012033196A1 (ja) | 発泡性エアゾール組成物 | |
| JPH0676314B2 (ja) | 坐剤基剤及び坐剤 | |
| JPH0840899A (ja) | 硝酸オキシコナゾールのエアゾール剤 | |
| JP3038837B2 (ja) | 皮膚冷却エアゾール剤 | |
| EP1019024B1 (en) | Aerosol ointment compositions | |
| CA2504807A1 (en) | Dermastick thickened ointment | |
| JP3658897B2 (ja) | エアゾール剤 | |
| EP1541144B1 (en) | Indometacin external preparation | |
| JP4521899B2 (ja) | クロタミトン含有皮膚外用液剤 | |
| CA2240684C (en) | Aerosol preparation | |
| JPH10287553A (ja) | エアゾール剤 | |
| JPS63201118A (ja) | 鎮痒剤 | |
| JPH1160471A (ja) | エアゾール剤 | |
| US20110237637A1 (en) | Metronidazole-based dermatological foam and emulsions for the production thereof | |
| Shirsath et al. | A review of pluronic lecithin organogel (PLO) as a topical and transdermal drug delivery system | |
| JPH09110677A (ja) | エアゾール剤 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |