CN1084404A

CN1084404A - Quick-acting antirheumatic

Info

Publication number: CN1084404A
Application number: CN93109223A
Authority: CN
Inventors: 孙宗魁
Original assignee: Individual
Current assignee: Individual
Priority date: 1993-08-05
Filing date: 1993-08-05
Publication date: 1994-03-30
Anticipated expiration: 2013-08-05
Also published as: CN1050289C

Abstract

The present invention relates to a kind of antirheumatic for the treatment of rheumatism disease.It is a raw material by 18 flavor Chinese medicines such as Radix Alangii, Daphne giraldii Nitsche, Herba Erodii, according to external, different therapeutic modality for oral administration, through alcohol-pickled, decocting such as boils at the medicine that different extraction processes is made, and can be processed into the various dosage forms of tincture, injection, capsule and oral liquid with raw material of Chinese medicine.Be mainly used in treating rheumatic arthritis, rheumatoid disease, have short treating period during treatment, the characteristics that cure rate is higher also have certain curative effect to other rheumatism.

Description

Quick-acting antirheumatic

The present invention relates to a kind of is the antirheumatic of raw material for treating rheumatism disease with the Chinese herbal medicine.

The medicine preparation that is used for the treatment of rheumatism disease now has much, though these Chinese medicine preparation energy disease controlling, relief of symptoms has certain curative effect, and treatment cycle is longer, and cure rate is not high.Its reason has two aspects, and the first, on the prescription compatibility, a little less than the power of often getting rid of evils, it is too urgent to set upright.According to theory of Chinese medical science, it is generally acknowledged that rheumatism disease is owing to the human body weakness, the yang-energy weakened defensive QI, the rheumatism heresy is taken advantage of a weak point, and invades and stays meridians, skin, joint, causes the QI and blood impatency, moves not smooth, limitation of activity, symptoms such as activities adverse thereby aching and tired, pain, numbness, heavy, swelling appear.Therefore, Therapeutic Method to be to get rid of evils, and drives to hold up (just) to lay equal stress on to be principle.Though existing prescription is as principle, but still be a little less than the power of getting rid of evils, and set upright too urgent, to the patients on long-term then to set upright.The second, on preparation technology, how the active ingredient of every flavor Chinese medicine is extracted, and the active ingredient that makes each Chinese medicine that extracts reaches best proportioning, and reach the effectiveness of getting rid of evils forcefully, and having centralizing function again simultaneously, this remains the problem that an end solves fully.

The objective of the invention is to overcome the deficiencies in the prior art, and a kind of short, higher strong rheumatismal antirheumatic of treatment of the power of getting rid of evils of the cure rate course of treatment that has is provided.

Quick-acting antirheumatic of the present invention is to be primary raw material with the following traditional Chinese medicines, through preferred compatibility, realizes that by processing technique such as immersion, decoctions the composition of its raw material (weight) is as follows:

Radix Alangii 5-20% Daphne giraldii Nitsche 10-20%

Buttercup 10-20% Herba Erodii 5-15%

Semen daturae 5-15% Radix Clematidis 3-9%

Flos Rhododendri Mollis 3-9% Radix Notoginseng 2.5-7.5%

Radix Astragali 2.5-7.5% Radix Glycyrrhizae 1-3%

Cortex Moutan 1-3% Lac regis apis 0.5-1.5%

Venenum apis 0.5-1.5 Stigma Croci 0.5-1.5%

Borneolum Syntheticum 0.4-1.2% Moschus 0.3-0.9%

Cornu rhinocerotis powder 0.2-0.6% sodium selenite 0.1-0.3%

According to external different therapeutic modality for oral administration, the dosage form of antirheumatic can this medicament be equipped with other auxiliary agents and be processed into tincture, capsule, injection or oral liquid.

It is as follows that the best that antirheumatic of the present invention is chosen raw material is formed (weight):

Radix Alangii 15%, Daphne giraldii Nitsche 15%, Herba Ranunculi Japonici 15%, Herba Erodii 10%, Semen daturae 10%, Radix Clematidis 6%, Flos Rhododendri Mollis 6%, Radix Notoginseng 5%, the Radix Astragali 5%, Radix Glycyrrhizae 2%, Cortex Moutan 6%, Lac regis apis 1%, Venenum apis 1%, Stigma Croci 1%, Borneolum Syntheticum 0.8%, Moschus 0.6%, Cornu rhinocerotis powder 0.4, sodium selenite 0.2

Technical process is as follows:

Each flavor Chinese medicine cleaned dry, pulverize separately sieves, and makes powdery, and wherein Lac regis apis and Venenum apis need not be made powdery.Earlier mix Radix Alangii, Daphne giraldii Nitsche, Herba Ranunculi Japonici, Herba Erodii, Semen daturae, Radix Clematidis, Flos Rhododendri Mollis, Radix Notoginseng, the Radix Astragali, Radix Glycyrrhizae and Cortex Moutan standby by proportion of composing.

(1) (a) mixed medicated powder is put into container, ethanol 35-40 part by 1 part of (weight) hybrid medicine adding 95% was soaked three to five days, stir once every day, then slag is filtered out, ethanol 30-35 part of reuse 95% rises soaked the slag leach three to five days, stir once every day, filters then, and the alcoholic solution after twice filtration is converted together;

(b) medicinal residues after filtering are for the second time added decocting in water 30 parts (weight) by 1 part of (weight) medicated powder and boiled 30 minutes, filter then, the slag after filtering is added 20 parts of decocting in water 30 minutes again, filter then, waste mixes up twice filtering aqueous solution, and heating is concentrated to 1/2 dense medicinal liquid;

(c) alcoholic solution is converted with dense medicinal liquid be in the same place, become medicament;

(d) Lac regis apis, Venenum apis, Stigma Croci (powdery after the clean solarization dry grinding), Borneolum Syntheticum (powdery), Moschus (powdery), Cornu rhinocerotis powder, sodium selenite (powdery) are added in the medicament, after stirring, filter, bottling carries out disinfection then;

Warehouse-in was deposited more than 2 months, promptly become can clinical use the rheumatism tincture.

(2) mix by Radix Alangii, Daphne giraldii Nitsche, Herba Ranunculi Japonici, Herba Erodii, Semen daturae, Radix Clematidis, Flos Rhododendri Mollis, Radix Notoginseng, the Radix Astragali, Radix Glycyrrhizae, Cortex Moutan, Venenum apis, Stigma Croci, Borneolum Syntheticum, Moschus, Cornu rhinocerotis powder and the sodium selenite of ratio of components cleaned solarization dry grinding, adding Lac regis apis stirs evenly, become and add capsular medicament, incapsulate by capsule medicament 18-22 part (weight), natural pollen 60-62 part (weight), starch 18-20 part (weight) and promptly can be used for the clinical rheumatism capsule of taking.

(3) (a) taking by weighing Radix Alangii, Daphne giraldii Nitsche, Herba Ranunculi Japonici, Herba Erodii, Semen daturae, Radix Clematidis, Flos Rhododendri Mollis, Radix Notoginseng, the Radix Astragali, Radix Glycyrrhizae, Cortex Moutan, Lac regis apis, Venenum apis, Stigma Croci, Borneolum Syntheticum, Moschus, Cornu rhinocerotis powder and sodium selenite by the raw material ratio of components mixes, add 35 parts of water (weight) with hybrid medicine 1 part (weight) and decocted 30 minutes, filter; Add 35 parts of (weight) water again, filtering residue was decocted 30 minutes for the second time, filter; Add 20 parts of (weight) water again, decocted for the third time 30 minutes, filter, collects three filtrate heating and be concentrated into 1/2 of former weight and obtain dense medicinal liquid.Knot filters, the decolouring bottling promptly become can clinical use the injection that seals of beating, obtain dense medicinal liquid.

(b) add 7-9 part Mel with above-mentioned dense medicinal liquid 91-93 part (weight), stir, the oral liquid bottle of the autoclave sterilization of packing into promptly becomes rheumatism oral liquid medicine.

In the processing technique used container be stainless or enamelled any.

Compare with existing antirheumatic by the antirheumatic of the present invention that above-mentioned technology is made, its superior part is: the drug effect height, and the course of treatment is shorter, and cure rate is higher.

Because the raw material that antirheumatic of the present invention is chosen has Radix Alangii, Daphne giraldii Nitsche, Venenum apis, sheep medicine, Semen daturae, Radix Clematidis, Herba Ranunculi Japonici and Herba Erodii make a noise, they have evil-wind expelling and dampness removing, heat-clearing and toxic substances removing, the effect of reducing swelling and alleviating pain, and their large percentages of accounting for, therefore, the power of getting rid of evils is stronger.These medicines to be belonged to hotly, has certain toxicity, therefore in the selecting materials of this technology, join one the Radix Astragali, Cortex Moutan, Radix Notoginseng, Radix Glycyrrhizae and Cornu rhinocerotis powder, in order to regulate toxicity, auxiliary treatment.Rheumatism tincture of the present invention is application compress, in order to strengthen drug effect, has mixed Moschus and Borneolum Syntheticum, and this two flavors medical instrument has the gas of fragrance, can infiltrate bone thoroughly by messenger drug.Increased Stigma Croci, Lac regis apis and sodium selenite in selecting materials simultaneously again, can invigorate blood circulation, nutrition and protection human body.Selecting materials of this technology guaranteed antiheumatic drug effect height, and the preparation process of this technology has guaranteed that also the active ingredient of the medicine of respectively distinguishing the flavor of can fully extract simultaneously, and obtains reasonable proportioning, has also guaranteed the drug effect height.

In clinical experiment, it is shorter that antirheumatic has demonstrated its course of treatment, the characteristics that cure rate is higher.To 1,000 many cases patient treatments, cure rate reaches 83.5%, and total effective rate reaches 97%, and general patient can cure substantially at 2-6 month.

Antirheumatic of the present invention cures mainly rheumatic arthritis, and rheumatoid disease also has certain curative effect to other rheumatisms.

Embodiment 1

A, with each independent crushing screening of cleaned drying in the sun Chinese medicine of distinguishing the flavor of, by 0.15 kilogram Radix Alangii, 0.15 kilogram Daphne giraldii Nitsche, 0.15 kilogram Herba Ranunculi Japonici, 0.1 kilogram Herba Erodii, 0.1 the Semen daturae of kilogram, 0.06 the Radix Clematidis of kilogram, 0.06 kilogram Flos Rhododendri Mollis, 0.05 kilogram Radix Notoginseng, 0.50 the Radix Astragali of kilogram, 0.02 the Radix Glycyrrhizae of kilogram, 0.06 kilogram Cortex Moutan is mixed into a medicated powder, 0.95 kilogram altogether;

B, a medicated powder (0.95 kilogram) is put into container, 35 kilograms of the ethanol of adding 95%, soaked three to five days, stir once every day, then slag is filtered out, the slag that 25 liters of immersions of reuse 95% ethanol leach three to five days, stir once every day, then slag is filtered, the solution after twice filtration is converted together; Liquid is converted together;

C, the medicinal residues that filter out are for the second time added 30 kilograms in water, boiled 30 minutes, filter then, the slag that filters out is added 20 kilograms in water again, boil and filtered then in 30 minutes, waste, with twice filtering aqueous solution, heating is concentrated to 25 kilograms;

D, alcoholic solution converted with aqueous solution be in the same place, become medicament;

E, with 0.05 kilogram Lac regis apis, 0.01 the Venenum apis of kilogram, 0.01 the Stigma Croci of kilogram (powdery after the clean solarization dry grinding), the Borneolum Syntheticum (powdery) of 8 grams, the Moschus (powdery) of 6 grams, 0.05 kilogram altogether of the sodium selenite (powdery) of the Cornu rhinocerotis powder of 4 grams and 2 grams, add in the medicament, after fully stirring, filter, high-temperature sterilization is carried out in bottling then;

After f, the high-temperature sterilization, after warehouse-in is deposited 2 months, be spendable rheumatism tincture medicine.

Embodiment 2

1.5 kilograms of the 1.5 kilograms of Daphne giraldii Nitsche of Radix Alangii, 1.5 kilograms of Herba Ranunculi Japonicis, 1 kilogram of Herba Erodii, 1 kilogram of Semen daturae, 0.6 kilogram of Radix Clematidis, 0.6 kilogram of Flos Rhododendri Mollis, 0.5 kilogram in Radix Notoginseng, 0.5 kilogram of the Radix Astragali, 0.2 kilogram in Radix Glycyrrhizae, 0.6 kilogram of Cortex Moutan, 0.1 kilogram of Venenum apis, 0.1 kilogram of Stigma Croci, 0.08 kilogram in Borneolum Syntheticum, 0.06 kilogram in Moschus, 0.04 kilogram of Cornu rhinocerotis powder, the sodium selenite that take by weighing the clean dry crushing screening mix for 0.5 kilogram, and the adding Lac regis apis stirs and is made into the capsule medicament.Totally 10 kilograms, add 30 kilograms of natural pollens, 10 kilograms of mixings of starch stir, divide the capsule of packing into the rheumatism capsule.

Example 3

With each cleaned drying in the sun Chinese medicine of distinguishing the flavor of, by 0.15 kilogram Radix Alangii, 0.15 kilogram Daphne giraldii Nitsche, 0.15 kilogram Herba Ranunculi Japonici, 0.15 the Herba Erodii of kilogram, 0.1 the Semen daturae of kilogram, 0.06 kilogram Wheeling is negative, 0.06 kilogram Flos Rhododendri Mollis, 0.05 the Radix Notoginseng of kilogram, 0.05 the Radix Astragali of kilogram, 0.02 kilogram Radix Glycyrrhizae, 0.06 kilogram Cortex Moutan, 0.01 kilogram of Lac regis apis, 0.01 kilogram of Venenum apis, 0.01 kilogram of Stigma Croci, Borneolum Syntheticum 8 grams, Moschus 6 grams, Cornu rhinocerotis powder 4 grams, inferior selenium glue sodium 2 grams are mixed into a medicine, 1 kilogram altogether; Add 35 kg of water and decocted 30 minutes, filter; Add 35 kg of water again and in filtering residue, decocted 30 minutes for the second time, filter; Add 30 kg of water for the third time again and fried in shallow oil again 30 minutes, filter; Get three filtrate heating and be concentrated to 50 kilograms of medicinal liquids, pack into, promptly make and clinically to spray the injection of sealing usefulness through the ampoule of high-temperature sterilization.

Embodiment 4

The concentrated medicament that makes with embodiment 3 same process adds 0.8 kilogram of Mel bottling for 9.2 kilograms, makes the rheumatism oral liquid.

Claims

1, a kind of antirheumatic is characterized in that this medicine is is primary raw material with the following traditional Chinese medicines, realizes that by immersion, decoction processing technique the composition of described raw material (weight) is:

Radix Alangii 5-20% Daphne giraldii Nitsche 10-20%

Buttercup 10-20% Herba Erodii 5-15%

Semen daturae 5-15% Radix Clematidis 3-9%

Flos Rhododendri Mollis 3-9% Radix Notoginseng 2.5-7.5%

Radix Astragali 2.5-7.5% Radix Glycyrrhizae 1-3%

Cortex Moutan 1-3% Lac regis apis 0.5-1.5%

Venenum apis 0.5-1.5 Stigma Croci 0.5-1.5%

Borneolum Syntheticum 0.4-1.2% Moschus 0.3-0.9%

Cornu rhinocerotis powder 0.2-0.6% sodium selenite 0.1-0.3%

Described medicine can be processed into tincture, capsule, injection or mouth through clothes liquid.

2, antirheumatic as claimed in claim 1 is characterized in that the best group of described raw material becomes: Radix Alangii 15%, Daphne giraldii Nitsche 15%, Herba Ranunculi Japonici 15%, Herba Erodii 10%, Semen daturae 10%, Radix Clematidis 6%, Flos Rhododendri Mollis 6%, Radix Notoginseng 5%, the Radix Astragali 5%, Radix Glycyrrhizae 2%, Cortex Moutan 6%, Lac regis apis 1%, Venenum apis 1%, Stigma Croci 1%, Borneolum Syntheticum 0.8%, Moschus 0.6%, Cornu rhinocerotis powder 0.4, sodium selenite 0.2.

3, antirheumatic as claimed in claim 1 is characterized in that the described technical process that is processed into tincture is:

(a) will clean to dry by ratio of components and be crushed and screened into powdered Radix Alangii, Daphne giraldii Nitsche, Herba Ranunculi Japonici, Herba Erodii, Semen daturae, Radix Clematidis, Flos Rhododendri Mollis, Radix Notoginseng, the Radix Astragali, Radix Glycyrrhizae and Cortex Moutan and mix, put into container, add 95% ethanol 35-40 part (weight) by 1 part of (weight) mixed powder, soaked three to five days, stir once every day, filters; Reuse 95% ethanol 30-35 part (weight) was soaked filtering residue three to five days, and stir once every day, filtered, twice ethanol filtrate is converted together,

(b) medicinal residues after will filtering add 30 parts of (weight) decocting in water 30 minutes by 1 part of (weight) medicated powder, filter, and the slag with after filtering adds 20 parts of (weight) decocting in water 30 minutes again, filter, and twice filtrate is mixed, and heating is concentrated to 1/2(weight) dense medicinal liquid,

(c) (a) ethanol filtrate converted with (b) dense medicinal liquid be in the same place, become medicament,

(d) Lac regis apis, Venenum apis, Stigma Croci, Borneolum Syntheticum, Moschus, Cornu rhinocerotis powder, sodium selenite are added in the medicament of (c), stir, filter, bottling, high-temperature sterilization,

(e) more than the bimester of depositing.

4,, it is characterized in that describedly being processed into capsular technical process and being as antirheumatic as described in the claim 1,3:

Radix Alangii, Daphne giraldii Nitsche, Herba Ranunculi Japonici, Herba Erodii, Semen daturae, Radix Clematidis, Flos Rhododendri Mollis, Radix Notoginseng, the Radix Astragali, Radix Glycyrrhizae, Cortex Moutan, Venenum apis, Stigma Croci, Borneolum Syntheticum, Moschus, Cornu rhinocerotis powder and the sodium selenite that to pulverize by ratio of components mix, add Lac regis apis and stir evenly into the capsule medicament, press capsule medicament 18-22 part (weight), natural pollen 60-62 part (weight), starch 18-20 part (weight), incapsulate.

5, antirheumatic as claimed in claim 1 is characterized in that the described technical process that is processed into injection is:

Taking by weighing Radix Alangii, Daphne giraldii Nitsche, Herba Ranunculi Japonici, Herba Erodii, Semen daturae, Radix Clematidis, Flos Rhododendri Mollis, Radix Notoginseng, the Radix Astragali, Radix Glycyrrhizae, Cortex Moutan, Lac regis apis, Venenum apis, Stigma Croci, Borneolum Syntheticum, Moschus, Cornu rhinocerotis powder and sodium selenite by the raw material ratio of components mixes, add 35 parts of water (weight) with hybrid medicine 1 part (weight) and decocted 30 minutes, filter; Add 35 parts of (weight) water again, decoct once again, filter; Add 30 parts of (weight) water again, decocted for the third time 30 minutes, filter, collect three filtrate heating and be concentrated into 1/2 of former filtrate, obtain dense medicinal liquid.Filter, decolour, bottle.

6, as claim 1,5 described antirheumatics, it is characterized in that the technical process that can be processed into oral liquid is: the dense medicinal liquid 91-93 part (weight) with 5 adds 7-9 part (weight) Mel and stirs, bottling.