CN1050289C - Quick-acting antirheumatic - Google Patents
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- CN1050289C CN1050289C CN93109223A CN93109223A CN1050289C CN 1050289 C CN1050289 C CN 1050289C CN 93109223 A CN93109223 A CN 93109223A CN 93109223 A CN93109223 A CN 93109223A CN 1050289 C CN1050289 C CN 1050289C
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Abstract
The present invention relates to anti-rheumatism medicine for treating rheumatic diseases, which uses 18 kinds of Chinese medicines as raw materials, such as Chinese alpine rush root, girald daphne bark, cranesbill, etc. According to different treatment ways of external application and oral administration, the raw materials are prepared into the medicine by the different extracting steps of alcohol immersion, water decoction, etc. The medicine can be processed into various types of preparations, such as tinctures, injections, capsules and oral liquids. The anti-rheumatism medicine of the present invention is mainly used for treating rheumarthritis and rheumatoid diseases. During treatment, the medicine of the present invention has the characteristics of short treatment course and high cure rate, and also as certain treatment effects on other rheumatic diseases.
Description
The present invention relates to a kind of is the antirheumatic of raw material for treating rheumatism disease with the Chinese herbal medicine.
The medicine preparation that is used for the treatment of rheumatism disease now has much, though these Chinese medicine preparation energy disease controlling, relief of symptoms has certain curative effect, and treatment cycle is longer, and cure rate is not high.Its reason has two aspects, and the first, on the prescription compatibility, a little less than the power of often getting rid of evils, it is too urgent to set upright.According to theory of Chinese medical science, it is generally acknowledged that rheumatism disease is owing to the human body weakness, the yang-energy weakened defensive QI, the rheumatism heresy is taken advantage of a weak point, and invades and stays meridians, skin, joint, causes the QI and blood impatency, moves not smooth, limitation of activity, symptoms such as activities adverse thereby aching and tired, pain, numbness, heavy, swelling appear.Therefore, Therapeutic Method to be to get rid of evils, and drives to hold up (just) to lay equal stress on to be principle.Though existing prescription is as principle, but still be a little less than the power of getting rid of evils, and set upright too urgent, to the patients on long-term then to set upright.The second, on preparation technology, how the active ingredient of every flavor Chinese medicine is extracted, and the active ingredient that makes each Chinese medicine that extracts reaches best proportioning, and reach the effectiveness of getting rid of evils forcefully, and having centralizing function again simultaneously, this remains the problem that an end solves fully.
The objective of the invention is to overcome the deficiencies in the prior art, and a kind of short, higher strong rheumatismal antirheumatic of treatment of the power of getting rid of evils of the cure rate course of treatment that has is provided.
Antirheumatic of the present invention is to be primary raw material with the following traditional Chinese medicines, through preferred compatibility, makes by processing technique such as immersion, decoctions, and the composition of its raw material (weight) is as follows:
Radix Alangii 5-20% Daphne giraldii Nitsche 10-20%
Buttercup 10-20% Herba Erodii 5-15%
Semen daturae 5-15% Radix Clematidis 3-9%
Flos Rhododendri Mollis 3-9% Radix Notoginseng 2.5-7.5%
Radix Astragali 2.5-7.5% Radix Glycyrrhizae 1-3%
Cortex Moutan 1-3% Lac regis apis 0.5-1.5%
Venenum apis 0.5-1.5% Stigma Croci 0.5-1.5%
Borneolum Syntheticum 0.4-1.2% Moschus 0.3-0.9%
Cornu rhinocerotis powder 0.2-0.6% sodium selenite 0.1-0.3%
According to external different therapeutic modality for oral administration, the dosage form of antirheumatic can this medicament be equipped with other auxiliary agents and be processed into tincture, capsule, injection or oral liquid.
It is as follows that the best that antirheumatic of the present invention is chosen raw material is formed (weight):
Radix Alangii 15%, Daphne giraldii Nitsche 15%, buttercup 15%, Herba Erodii 10%, Semen daturae 10%, Radix Clematidis 6%, Flos Rhododendri Mollis 6%, Radix Notoginseng 5%, the Radix Astragali 5%, Radix Glycyrrhizae 2%, Cortex Moutan 6%, Lac regis apis 1%, Venenum apis 1%, Stigma Croci 1%, Borneolum Syntheticum 0.8%, Moschus 0.6%, Cornu rhinocerotis powder 0.4%, sodium selenite 0.2%.
Technical process is as follows:
Each flavor Chinese medicine cleaned dry, pulverize separately sieves, and makes powdery, and wherein Lac regis apis and Venenum apis need not be made powdery.Earlier mix Radix Alangii, Daphne giraldii Nitsche, buttercup, Herba Erodii, Semen daturae, Radix Clematidis, Flos Rhododendri Mollis, Radix Notoginseng, the Radix Astragali, Radix Glycyrrhizae and Cortex Moutan standby by proportion of composing.
(1) (a) mixed medicated powder is put into container, ethanol 35-40 part by 1 part of (weight) hybrid medicine adding 95%, soaked three to five days, stir once every day, then slag is filtered out, ethanol 30-35 part of reuse 95% rises soaked the slag leach three to five days, and stir once every day, filter then, the alcoholic solution after twice filtration is converted together;
(b) medicinal residues after filtering are for the second time added water 30 parts (weight) by 1 part of (weight) medicated powder and boiled 30 minutes, filter then, the slag after filtering is added 20 parts of decocting in water 30 minutes again, filter then, waste mixes up twice filtering aqueous solution, and heating is concentrated to 1/2 dense medicinal liquid;
(c) alcoholic solution is converted with dense medicinal liquid be in the same place, become medicament;
(d) Lac regis apis, Venenum apis, Stigma Croci (powdery after the clean solarization dry grinding), Borneolum Syntheticum (powdery), Moschus (powdery), Cornu rhinocerotis powder, sodium selenite (powdery) are added in the medicament, after stirring, filter, bottling carries out disinfection then;
Warehouse-in was deposited more than 2 months, promptly become can clinical use the rheumatism tincture.
(2) mix by Radix Alangii, Daphne giraldii Nitsche, buttercup, Herba Erodii, Semen daturae, Radix Clematidis, Flos Rhododendri Mollis, Radix Notoginseng, the Radix Astragali, Radix Glycyrrhizae, Cortex Moutan, Venenum apis, Stigma Croci, Borneolum Syntheticum, Moschus, Cornu rhinocerotis powder and the sodium selenite of ratio of components cleaned solarization dry grinding, adding Lac regis apis stirs evenly, be processed into capsular medicament, incapsulate by capsule medicament 18-22 part (weight), natural pollen 60-62 part (weight), starch 18-20 part (weight) and promptly can be used for the clinical rheumatism capsule of taking.
(3) (a) taking by weighing Radix Alangii, Daphne giraldii Nitsche, buttercup, Herba Erodii, Semen daturae, Radix Clematidis, Flos Rhododendri Mollis, Radix Notoginseng, the Radix Astragali, Radix Glycyrrhizae, Cortex Moutan, Lac regis apis, Venenum apis, Stigma Croci, Borneolum Syntheticum, Moschus, Cornu rhinocerotis powder and sodium selenite by the raw material ratio of components mixes, add 35 parts of water (weight) with hybrid medicine 1 part (weight) and decocted 30 minutes, filter; Add 35 parts of (weight) water again, filtering residue was decocted 30 minutes for the second time, filter; Add 30 parts of (weight) water again, decocted for the third time 30 minutes, filter, collects three filtrate heating and be concentrated into 1/2 of former weight and obtain dense medicinal liquid.After filtration, decolouring bottling promptly become can clinical use the injection that seals of beating.
(b) add 7-9 part Mel with above-mentioned dense medicinal liquid 91-93 part (weight), stir, the oral liquid bottle of the autoclave sterilization of packing into promptly becomes rheumatism oral liquid medicine.
In the processing technique used container be stainless or enamelled any.
Compare with existing antirheumatic by the antirheumatic of the present invention that above-mentioned technology is made, its superior part is: the drug effect height, and the course of treatment is shorter, and cure rate is higher.
Because the raw material that antirheumatic of the present invention is chosen has Radix Alangii, Daphne giraldii Nitsche, Venenum apis, Flos Rhododendri Mollis, Semen daturae, Radix Clematidis, buttercup and Herba Erodii, evil-wind expelling and dampness removing, heat-clearing and toxic substances removing are arranged, the effect of reducing swelling and alleviating pain, and their large percentages of accounting on them, therefore, the power of getting rid of evils is stronger.These medicines to be belonged to hotly, has certain toxicity, therefore in the selecting materials of this technology, join one the Radix Astragali, Cortex Moutan, Radix Notoginseng, Radix Glycyrrhizae and Cornu rhinocerotis powder, in order to regulate toxicity, auxiliary treatment.Antirheumatic tincture of the present invention is application compress, in order to strengthen drug effect, has mixed Moschus and Borneolum Syntheticum, and this two flavors medical instrument has the gas of fragrance, can infiltrate bone thoroughly by messenger drug.Increased Stigma Croci, Lac regis apis and sodium selenite in selecting materials simultaneously again, can invigorate blood circulation, nutrition and protection human body.Selecting materials of this technology guaranteed antiheumatic drug effect height, and the preparation process of this technology has guaranteed that also the active ingredient of the medicine of respectively distinguishing the flavor of can fully extract simultaneously, and obtains reasonable proportioning, has also guaranteed the drug effect height.
In clinical experiment, it is shorter that antirheumatic has demonstrated its course of treatment, the characteristics that cure rate is higher.To 1,000 many cases patient treatments, cure rate reaches 83.5% total effective rate and reaches 97%, and general patient can cure substantially at 2-6 month.Antirheumatic of the present invention cures mainly rheumatic arthritis, rheumatoid disease, and other rheumatisms are also had certain curative effect.
Embodiment 1
A, with each independent crushing screening of cleaned drying in the sun Chinese medicine of distinguishing the flavor of, by 0.15 kilogram Radix Alangii, 0.15 kilogram Daphne giraldii Nitsche, 0.15 kilogram buttercup, 0.1 the Herba Erodii of kilogram, 0.1 the Semen daturae of kilogram, 0.06 the Radix Glycyrrhizae that the Radix Clematidis of kilogram is 0.06 kilogram, 0.06 the Cortex Moutan of kilogram is mixed into a medicated powder, 0.95 kilogram altogether;
B, a medicated powder (0.95 kilogram) is put into container, 35 kilograms of the ethanol of adding 95%, soaked three to five days, stir once every day, then slag is filtered out, the slag that 25 liters of immersions of reuse 95% ethanol leach three to five days, stir once every day, then slag is filtered, the solution after twice filtration is converted together;
C, the medicinal residues that filter out are for the second time added 30 kilograms in water, boiled 30 minutes, filter then, the slag that filters out is added 20 kilograms in water again, boil and filtered then in 30 minutes, waste, with twice filtering aqueous solution, heating is concentrated to 25 kilograms;
D, alcoholic solution converted with aqueous solution be in the same place, become medicament;
E, with 0.05 kilogram Lac regis apis, 0.01 the Venenum apis of kilogram, 0.01 the Stigma Croci of kilogram (powdery after the clean solarization dry grinding), the Borneolum Syntheticum (powdery) of 8 grams, the Moschus (powdery) of 6 grams, 0.05 kilogram altogether of the sodium selenite (powdery) of the Cornu rhinocerotis powder of 4 grams and 2 grams, add in the medicament, after fully stirring, filter, high-temperature sterilization is carried out in bottling then;
After f, the high-temperature sterilization, after warehouse-in is deposited 2 months, be spendable rheumatism tincture medicine.
Embodiment 2
Take by weighing 1.5 kilograms of the Radix Alangiis of clean dry crushing screening, 1.5 kilograms of Daphne giraldii Nitsche, 1.5 kilograms of buttercup, 1 kilogram of Herba Erodii, 1 kilogram of Semen daturae, 0.6 kilogram of Radix Clematidis, 0.6 kilogram of Flos Rhododendri Mollis, 0.5 kilogram of Radix Notoginseng, 0.5 kilogram of the Radix Astragali, 0.2 kilogram in Radix Glycyrrhizae, 0.6 kilogram of Cortex Moutan, 0.1 kilogram of Venenum apis, 0.1 kilogram of Stigma Croci, 0.08 kilogram in Borneolum Syntheticum, 0.06 kilogram in Moschus, 0.04 kilogram of Cornu rhinocerotis powder, sodium selenite mixes for 0.5 kilogram, and the adding Lac regis apis stirs and is made into the capsule medicament.Totally 10 kilograms, add 30 kilograms of natural pollens, 10 kilograms of mixings of starch stir, divide the capsule of packing into the rheumatism capsule.
Embodiment 3
With each cleaned drying in the sun Chinese medicine of distinguishing the flavor of, by 0.15 kilogram Radix Alangii, 0.15 kilogram Daphne giraldii Nitsche, 0.15 kilogram buttercup, 0.15 kilogram Herba Erodii, 0.1 kilogram Semen daturae, 0.06 kilogram Radix Clematidis, 0.06 kilogram Flos Rhododendri Mollis, 0.05 kilogram Radix Notoginseng, 0.05 kilogram the Radix Astragali, 0.02 kilogram Radix Glycyrrhizae, 0.06 the Cortex Moutan of kilogram, 0.01 kilogram Lac regis apis, 0.01 kilogram Venenum apis, 0.01 kilogram Stigma Croci, Borneolum Syntheticum 8 grams, Moschus 6 grams, Cornu rhinocerotis powder 4 grams, sodium selenite 2 grams are mixed into a medicine, 1 kilogram altogether; Add 35 kg of water and decocted 30 minutes, filter; Add 35 kg of water again and in filtering residue, decocted 30 minutes for the second time, filter; Add 32 kg of water for the third time again and fried in shallow oil again 30 minutes, filter; Get three filtrate heating and be concentrated to 50 kilograms of medicinal liquids, pack into, promptly make and clinically to spray the injection of sealing usefulness through the ampoule of high-temperature sterilization.
Embodiment 4
The concentrated medicament that makes with embodiment 3 same process adds 0.8 kilogram of Mel bottling for 9.2 kilograms, makes the rheumatism oral liquid.
Claims (6)
1, a kind of antirheumatic is characterized in that this medicine is is primary raw material with the following traditional Chinese medicines, by soak,
The decoction processing technique is made, and the weight of described raw material consists of: the described medicine of Radix Alangii 5-20% Daphne giraldii Nitsche 10-20% buttercup 10-20% Herba Erodii 5-15% Semen daturae 5-15% Radix Clematidis 3-9% Flos Rhododendri Mollis 3-9% Radix Notoginseng 2.5-7.5% Radix Astragali 2.5-75% Radix Glycyrrhizae 1-3% Cortex Moutan 1-3% Lac regis apis 0.5-1.5% Venenum apis 0.5-1.5% Stigma Croci 0.5-1.5% Borneolum Syntheticum 0.4-1.2% Moschus 0.3-0.9% Cornu rhinocerotis powder 0.2-0.6% sodium selenite 0.1-0.3% is processed into tincture, capsule, injection or oral liquid.
2, antirheumatic as claimed in claim 1 is characterized in that the weight of described raw material consists of: Radix Alangii 15%, Daphne giraldii Nitsche 15%, buttercup 15%, Herba Erodii 10%, Semen daturae 10%, Radix Clematidis 6%, Flos Rhododendri Mollis 6%, Radix Notoginseng 5%, the Radix Astragali 5%, Radix Glycyrrhizae 2%, Cortex Moutan 6%, Lac regis apis 1%, Venenum apis 1%, Stigma Croci 1%, Borneolum Syntheticum 0.8%, Moschus 0.6%, Cornu rhinocerotis powder 0.4%, sodium selenite 0.2%.
3, antirheumatic as claimed in claim 1 is characterized in that the described technical process that is processed into tincture is:
(a) ratio of components will be cleaned to dry and be crushed and screened into powdered Radix Alangii, Daphne giraldii Nitsche, buttercup, Herba Erodii, Semen daturae, Radix Clematidis, Flos Rhododendri Mollis, Radix Notoginseng, the Radix Astragali, Radix Glycyrrhizae and Cortex Moutan and mix by weight, put into container, add 95% ethanol 35-40 part by 1 part of mixed powder, soaked three to five days, stir once every day, filters; Reuse 95% ethanol 30-35 part was soaked filtering residue three to five days, and stir once every day, filtered, twice ethanol filtrate is converted together,
(b) medicinal residues after will filtering add 30 parts of water by weight 1 part of medicated powder, boil 30 minutes, filter, and the slag with after filtering adds 20 parts of water again, boils 30 minutes, filter, and twice filtrate is mixed, and heating is concentrated to 1/2 dense medicinal liquid,
(c) (a) ethanol filtrate converted with (b) dense medicinal liquid be in the same place, become medicament,
(d) Lac regis apis, Venenum apis, Stigma Croci, Borneolum Syntheticum, Moschus, Cornu rhinocerotis powder, sodium selenite are added in the medicament of (c), stir, filter, bottling, high-temperature sterilization,
(e) more than the bimester of depositing.
4, antirheumatic as claimed in claim 1 is characterized in that describedly being processed into capsular technical process and being:
The Radix Alangii that to pulverize of ratio of components, Daphne giraldii Nitsche, buttercup, Herba Erodii, Semen daturae, Radix Clematidis, Flos Rhododendri Mollis, Radix Notoginseng, the Radix Astragali, Radix Glycyrrhizae, Cortex Moutan, Lac regis apis, Venenum apis, Stigma Croci, Borneolum Syntheticum, Moschus, Cornu rhinocerotis powder and sodium selenite mix by weight, add Lac regis apis and stir evenly into the capsule medicament, press capsule medicament 18-22 part, natural pollen 60-62 part, starch 18-20 part, incapsulate.
5, antirheumatic as claimed in claim 1 is characterized in that the described technical process that is processed into injection is:
Taking by weighing Radix Alangii, Daphne giraldii Nitsche, buttercup, Herba Erodii, Semen daturae, Radix Clematidis, Flos Rhododendri Mollis, Radix Notoginseng, the Radix Astragali, Radix Glycyrrhizae, Cortex Moutan, Lac regis apis, Venenum apis, Stigma Croci, Borneolum Syntheticum, Moschus, Cornu rhinocerotis powder and sodium selenite by the raw material weight ratio of components mixes, add 35 parts of water with 1 part of hybrid medicine, decocted 30 minutes, and filtered; Add 35 parts of water again, decoct once again, filter; Add 30 parts of water again, decocted for the third time 30 minutes, filter, collect three filtrate heating and be concentrated into 1/2 of former filtrate, obtain dense medical filtration, decolouring, bottling.
6, antirheumatic as claimed in claim 1 is characterized in that the technical process of described processing oral liquid is: with described constitutive material, ratio of components adds 35 parts of water with 1 part of constitutive material by weight, decocts 30 minutes; Repeat to decoct with water once; Add 30 parts of decoctings again and boiled 30 minutes, collect three times filtrate, heating is concentrated into 1/2 of original liquid, makes dense medicinal liquid, adds 7-9 part Mel by dense medicinal liquid 91-93 part (weight) again and stirs bottling.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN93109223A CN1050289C (en) | 1993-08-05 | 1993-08-05 | Quick-acting antirheumatic |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN93109223A CN1050289C (en) | 1993-08-05 | 1993-08-05 | Quick-acting antirheumatic |
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CN1084404A CN1084404A (en) | 1994-03-30 |
CN1050289C true CN1050289C (en) | 2000-03-15 |
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CN93109223A Expired - Fee Related CN1050289C (en) | 1993-08-05 | 1993-08-05 | Quick-acting antirheumatic |
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Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1063046C (en) * | 1997-09-10 | 2001-03-14 | 沈春楼 | Anti-rheumatism capsule curing rheumatoid disease through immunity regulation |
CN102302616B (en) * | 2011-09-23 | 2013-03-06 | 呼永河 | Cataplasm for treating knee osteoarthritis and preparation method thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1030701A (en) * | 1987-05-20 | 1989-02-01 | 宁士勋 | A kind of preparation method of anti-rheumatism bony spur |
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1993
- 1993-08-05 CN CN93109223A patent/CN1050289C/en not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1030701A (en) * | 1987-05-20 | 1989-02-01 | 宁士勋 | A kind of preparation method of anti-rheumatism bony spur |
Non-Patent Citations (4)
Title |
---|
四川中医1982,(1) 1982.1.31 黄绍祥,中药治疗风湿性关节炎16例 * |
四川中医1982,(1) 1982.1.31 黄绍祥,中药治疗风湿性关节炎16例;四川中医1983,(4) 1985.4.30 罗凤美,白龙须治疗痹症;四川中医1984,2(6) 1984.6.30 张应学,外敷法治疗类风湿性关节炎 * |
四川中医1983,(4) 1985.4.30 罗凤美,白龙须治疗痹症 * |
四川中医1984,2(6) 1984.6.30 张应学,外敷法治疗类风湿性关节炎 * |
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