CN1142391A

CN1142391A - Oral liquid

Info

Publication number: CN1142391A
Application number: CN96108400A
Authority: CN
Inventors: 苏优强
Original assignee: Individual
Current assignee: Individual
Priority date: 1996-07-05
Filing date: 1996-07-05
Publication date: 1997-02-12
Anticipated expiration: 2016-07-05
Also published as: CN1062463C

Abstract

An oral liquid for curing acute and chronic hepatitides, hepatosplenomegaly and early cirrhosis with high curative effect is prepared from 19 Chinese-medicinal materials including giant knotweed rhizome, Threeflower blue beard, flavescent sophora root, abrus cantoniensis and red peony root, etc.

Description

Oral liquid

The present invention relates to a kind of medicinal preparation that combines by Chinese herbal medicine, especially a kind of oral liquid for the treatment of hepatopathy.

Various hepatopathys comprise acute, chronic hepatitis, hepatosplenomegaly etc., are a kind of commonly encountered diseases and frequently-occurring disease, especially the hepatopathy that causes of hepatitis B virus seriously endangers the healthy of people, after the morbidity, as untimely treatment, very easily develop into liver cirrhosis even be converted into hepatocarcinoma.According to statistics, China's hepatitis B virus carriers accounts for population 10%, and wherein the hepatitis B hotspot accounts for more than 25%.In hepatitis B virus carriers, have 10% to be hepatitis B patient approximately.Clinically, hepatitis B and hepatitis B virus carriers are not still had specific drug, adopt the method for some liver protecting therapies more, though also obtain certain effect, not obvious.Domestic how useful Chinese herb medicine or therapy of combining Chinese and Western medicine hepatopathy, but it is not high that hepatitis B virus is carried patient's treatment negative conversion rate yet.

The object of the present invention is to provide a kind of to acute, chronic hepatitis, hepatosplenomegaly, particularly remarkable, and to the effective herbal composite of hepatitis B virus carriers to the treating hepatitis B effect.

The scheme that the object of the invention realizes is: this herbal composite comprises that big acute diseases such as cholera and sunstroke medicine root, Folium Malloti Apeltae root, polygoni cuspidati,radix, crow do not moor root, Radix seu Folium Rubi alceaefolii, Serissa foetida, Radix Sophorae Flavescentis, Herba Abri (herb), wood sunset (herb), Herba Hyperici Japonici (herb), Chinese Lobelia (herb), Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Herba Artemisiae Scopariae, Semen Pittospori Glabrati, Fructus Toosendan, Radix Bupleuri, Radix Isatidis, Herba Plantaginis.

Above-mentioned composition is to prepare in following ratio (weight): big acute diseases such as cholera and sunstroke medicine root 1.5-2.5, Folium Malloti Apeltae root 1.5-2.5, polygoni cuspidati,radix 1.5-2.4, crow is not moored root 1.5-2.0, Radix seu Folium Rubi alceaefolii 1.5-2.0, Serissa foetida 1.5-2.4, Radix Sophorae Flavescentis 1.5-2.0, Herba Abri 1.5-2.0, wood sunset 0.7-1.0, Herba Hyperici Japonici 1.2-1.5, Chinese Lobelia 1.2-1.5, Radix Paeoniae Rubra 1.2-1.5, Radix Salviae Miltiorrhizae 1.2-1.5, Herba Artemisiae Scopariae 1.2-1.5, Semen Pittospori Glabrati 0.7-1.0, Fructus Toosendan 0.7-1.0, Radix Bupleuri 0.9-1.2, Radix Isatidis 1.5-1.8, Herba Plantaginis 0.7-1.0.

In the above-mentioned composition, each medicine has following function respectively.

Big acute diseases such as cholera and sunstroke medicine root, have another name called yellow sand medicine (seeing that Bobai County revolutionary committee, the Chinese People's Liberation Army 1 stay Bobai County 626 sanitary work teams and compile " Chinese herbal medicine choosing " 206 pages): dispersing liver and promoting blood circulation, detoxifcation, removing mass, softening the hard mass;

Wu Bubo, have another name called thorn downtree (see that Guangzhou army rear service portion compiles, the 70 years versions in People's Health Publisher " 590 pages of Chinese herbal medicine handbook commonly used): soothing the liver sharp blood, removing mass softening the hard mass;

Semen Pittospori Glabrati, have another name called HUANGZHIZI (ibid, 193 pages): detoxifcation, removing heat from blood, liver heat removing gallbladder, diuretic;

Folium Malloti Apeltae, have another name called Folium Malloti Apeltae (see national Chinese herbal medicine write group and compile, 297 pages of People's Health Publisher's version " national Chinese herbal medicine compilation " (hereinafter to be referred as compilation) in 1975 first volumes): dispersing liver and promoting blood circulation collateral dredging, detoxifcation, function of gallbladder promoting dry;

Rhizoma Polygoni Cuspidati (508 pages of " compilation " first volumes): dispel the wind, dampness removing, removing blood stasis with potent drugs, stimulate the menstrual flow, detoxifcation, liver heat removing function of gallbladder promoting;

Radix seu Folium Rubi alceaefolii, have another name called Radix seu Folium Rubi alceaefolii (37 pages of " compilation " volume two): dispersing liver and promoting blood circulation, removing mass softening the hard mass, detoxifcation;

Serissa foetida (138 pages of " compilation " first volumes): liver heat removing, detoxifcation, diuretic;

Radix Sophorae Flavescentis (516 pages of " compilation " first volumes): liver heat removing function of gallbladder promoting, removing pathogenic heat from blood and toxic substance from the body, dampness;

Herba Abri (compilation " first volume 430 pages): liver heat removing, removing pathogenic heat from blood and toxic substance from the body;

Wood sunset, have another name called Herba Clinopodii Polycephali, Herba Eguiseti Debilis (270 pages of " compilation " first volumes): the liver heat removing function of gallbladder promoting, make eye bright;

Herba Hyperici Japonici, have another name called Herba Hyperici Japonici (336 pages of " compilation " first volumes): detoxifcation is dried, the diuretic jaundice eliminating;

Chinese Lobelia, have another name called Herba Hedyotidis Diffusae (289 pages of " compilation " first volumes): liver heat removing function of gallbladder promoting, wet, the diuretic of disintoxication;

Radix Paeoniae Rubra (405 pages of " compilation " first volumes): invigorate blood circulation, removing blood stasis with potent drugs;

Radix Salviae Miltiorrhizae (216 pages of " compilation " first volumes): promoting blood circulation and breaking stagnation, infiltration blood vessel;

Artemisia anethoicles Mattf (606 pages of " compilation " first volumes): liver heat removing function of gallbladder promoting, clearing away heat-damp and promoting diuresis, detoxifcation jaundice eliminating;

Fructus Toosendan (135 pages of " compilation " first volumes): dispersing the stagnated live-QI to relieve the stagnation of QI, remove damp and hot, pain relieving;

Radix Bupleuri (691 pages of " compilation " first volumes): dispersing the stagnated live-QI to relieve the stagnation of QI, yang invigorating;

Radix Isatidis (497 pages of " compilation " first volumes): liver heat removing, detoxifcation;

Herba Plantaginis (169 pages of " compilation " first volumes): the diuretic that dries, clearing away heat to improve acuity of vision.

The present invention is in after the assembly of said medicine ratio, is prepared into oral liquid through conventional technology decoction, concentrate etc.Obviously, the invention is not restricted to a kind of dosage form of oral liquid, also can make other dosage forms, and have equal curative effect by common pharmaceutical technology.

Oral liquid of the present invention has dispersing liver and promoting blood circulation, and clearing heat secreting bile is removed virus, and diuretic dries, functions such as softening the hard mass resolving depression.To various acute, chronic hepatitis, hepatosplenomegaly, early stage liver cirrhosis has good effect.Warp is taken observation to nearly 2000 person-times, and per day for adults is taken this oral liquid 2 times, each 25-30ml, and to acute, chronic hepatitis, particularly hepatitis B, and hepatosplenomegaly effective percentage reaches more than 90%; Hepatitis B virus bacillicarrier negative conversion rate is reached 60%.

The clinical observation example:

1. Zhou Yuanyun, man, 31 years old, peasant, diagnosis and treatment on April 1 in 74 year.The private prosecution inappetence, food is pressed full, and upper abdomen does not relax, hepatalgia.Check: stringy and tense pulse, heart rate is accelerated, and 90 times/minute, extremity are thin and weak, and breast has spider angioma, abdominal part swelling, 110 centimeters of abdominal circumferences, the slight edema of lower limb, two hands liver palms, the tongue eyeball, ascites liver spleen can not touch.Liver function experience: zinc turbidity 46, transaminase 185 units, liver cirrhosis.Adopt the attacking the pathogens first and then tonifying method, promptly obey two days oral liquids of the present invention and mend one day compound recipe Pingwei San, alternately take.Treated 10 days, ascites is dwindled 30 centimeters.Treating four months livers dwindles and has only two centimeters.Treat and did the liver function check in six months, zinc turbidity 10 units, the transaminase 41, and spleen is contracted to 2 centimeters for preceding 4 centimeters by treatment, and deliquescing.Complexion is by the dark and gloomy gloss that becomes, and appetite increases and can participate in slight work.

2. ten younger brothers Lee, 13 years old, man.Whole body is become thin, and three centimeters of hepatomegaly are medium hard, no ligament, no ascites, one centimeter of splenomegaly.Hepatalgia, body of the tongue is dark violet, and breast has spider angioma, stringy and tense pulse.TTT10 unit, CPT126 unit, globulin 5, albumin 6.Be diagnosed as liver cirrhosis through county hospital.Take a turn for the better with three months symptoms of oral liquid treatment of the present invention, liver function is checked every index near normal.

3. yellow brightness, man, 32 years old, live the rural area.The long-term fatigue and weak of patient, inappetence, big belly 3 years.Do liver function test in nineteen ninety to county hospital, the HBSAg positive, the HBeAg positive, the HBC positive.Be diagnosed as chronic hepatitis B.Through taking oral liquid of the present invention check in 6 months, three sun are turned out cloudy.

Fruit just contain, man, 52 years old.Patient's fatigue and weak, inappetence, upper abdomen do not relax.Be diagnosed as chronic active type hepatitis B through county hospital.Once failed to respond to any medical treatment to how tame large hospital.It is obvious to treat first three big sun, and through taking oral liquid of the present invention three months, symptom takes a turn for the better, and the chemical examination liver function is every all normal, turning out cloudy property of HBSAg.

Embodiment

Get big acute diseases such as cholera and sunstroke medicine root 2000 grams, Folium Malloti Apeltae root 2000 grams, polygoni cuspidati,radix 2000 grams, crow are not moored root 1650 grams, Radix seu Folium Rubi alceaefolii 1650 grams, Serissa foetida 2000 grams, Radix Sophorae Flavescentis 1650 grams, Herba Abri 1650 grams, wood sunset 850 restrain, Herba Hyperici Japonici 1350 grams, Chinese Lobelia 1350 grams, Radix Paeoniae Rubra 1350 grams, Radix Salviae Miltiorrhizae 1350 grams, Artemisia anethoicles Mattf 1350 grams, Semen Pittospori Glabrati 850 grams, Fructus Toosendan 850 grams, Radix Bupleuri 1000 grams, Radix Isatidis 1650 grams, Herba Plantaginis 850 grams.Said medicine is clean, cutting are put into pot and are decocted with water 2 hours, collect medicinal liquid and deposit in addition, medicinal residues add suitable quantity of water again and decocted 1 hour, and removing slag merges filtration with the secondary medicinal liquid, gets filtrate and is concentrated into 5000 milliliters, add sucrose 1500 grams, sodium benzoate 20 grams are mixed well and are promptly got oral liquid.

Also can disclosed in this manual compositions and each component ratio scope in, take by weighing various medicines arbitrarily after, prepare oral liquid by the foregoing description method.

Claims

1. oral liquid is characterized in that comprising in the compositions: big acute diseases such as cholera and sunstroke medicine root, and the Folium Malloti Apeltae root, polygoni cuspidati,radix, crow is not moored root, Radix seu Folium Rubi alceaefolii, Serissa foetida, Radix Sophorae Flavescentis, Herba Abri, wood sunset, Herba Hyperici Japonici, Chinese Lobelia, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, Herba Artemisiae Scopariae, Semen Pittospori Glabrati, Fructus Toosendan, Radix Bupleuri, Radix Isatidis, Herba Plantaginis.

2. according to the described oral liquid of claim 1, it is characterized in that each composition weight ratio scope is as follows in the compositions: big acute diseases such as cholera and sunstroke medicine root 1.5-2.5, Folium Malloti Apeltae root 1.5-2.5, polygoni cuspidati,radix 1.5-2.4, crow is not moored root 1.5-2.0, Radix seu Folium Rubi alceaefolii 1.5-2.0, Serissa foetida 1.5-2.4, Radix Sophorae Flavescentis 1.5-2.0, Herba Abri 1.5-2.0, wood sunset 0.7-1.0, Herba Hyperici Japonici 1.2-1.5, Chinese Lobelia 1.2-1.5, Radix Paeoniae Rubra 1.2-1.5, Radix Salviae Miltiorrhizae 1.2-1.5, Herba Artemisiae Scopariae 1.2-1.5, Semen Pittospori Glabrati 0.7-1.0, Fructus Toosendan 0.7-1.0, Radix Bupleuri 0.9-1.2, Radix Isatidis 1.5-1.8, Herba Plantaginis 0.7-1.0.

3. according to claim 1 or 2 described oral liquids, it is characterized in that each components by weight for example down in the compositions: big acute diseases such as cholera and sunstroke medicine root 2.0, Folium Malloti Apeltae root 2.0, polygoni cuspidati,radix 2.0, crow is not moored root 1.65, Radix seu Folium Rubi alceaefolii 1.65, Serissa foetida 2.0, Radix Sophorae Flavescentis 1.65, Herba Abri 1.65, wood sunset 0.85, Herba Hyperici Japonici 1.35, Chinese Lobelia 1.35, Radix Paeoniae Rubra 1.35, Radix Salviae Miltiorrhizae 1.35, Herba Artemisiae Scopariae 1.35, Semen Pittospori Glabrati 0.85, Fructus Toosendan 0.85, Radix Bupleuri 1.0, Radix Isatidis 1.65, Herba Plantaginis 0.85.