CN108434198A - A kind of preparation method of slow-release lamiophlomis rotata medicine materical crude slice - Google Patents
A kind of preparation method of slow-release lamiophlomis rotata medicine materical crude slice Download PDFInfo
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- CN108434198A CN108434198A CN201810459696.2A CN201810459696A CN108434198A CN 108434198 A CN108434198 A CN 108434198A CN 201810459696 A CN201810459696 A CN 201810459696A CN 108434198 A CN108434198 A CN 108434198A
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- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The invention discloses a kind of preparation methods of slow-release lamiophlomis rotata medicine materical crude slice, specific preparation process is by auxiliary material Chinese aloe root, shellfish tooth, Radix Notoginseng, phoenix-tail fern, the mixed extract of rhizoma imperatae and hawthorn, radix bupleuri, mountain Cape jasmine, mulberry leaf, the Fructus Sophorae, spray liquid is made after the concoction mixing that Inula britannica chinensis is decocted, then lamiophlomis rotata is lived with gauze wrapped, intermittent spray is carried out using spray liquid, then it cuts into slice after again air-drying the lamiophlomis rotata after spray and is put into vacuum tank and carry out oscillation rotation, sustained release emulsion is injected into using HP jetting pump in container in oscillatory process, packaging will be finally carried out after chip drying can be prepared by a kind of slow-release lamiophlomis rotata medicine materical crude slice.Method provided by the invention can not only improve lamiophlomiol and quercetin content in lamiophlomis rotata, enhance pharmacological property, while can also delay the loss of medicinal material property of traditional Chinese when brewing so that lamiophlomis rotata medicine materical crude slice, which brews 23 times, still has good medical value.
Description
Technical field
The invention belongs to process of preparing technical fields, and in particular to a kind of preparation method of slow-release lamiophlomis rotata medicine materical crude slice.
Background technology
Lamiophlomis rotata, alias：Bus plays cloth bar, and Labiatae lamiophlomis rotata belongs to unique species, and perennial herb, blade is in radiation
Shape, it is two-by-two relatively, bitter, it is slightly cold, there is the effect of promoting blood circulation, swelling and pain relieving.Civil common all herbal medicine, control traumatic injury,
Arthralgia and myalgia, the stagnation of the circulation of vital energy sprain one's back, flow yellow water, joint product yellow water, cancellous bone inflammation after edema.
Lamiophlomis rotata medicine materical crude slice prepared by currently available technology, the lamiophlomiol and quercetin content contained is relatively low, is rushed with boiling water
Bubble is drunk with comedicine with pan-fried, can only be brewed once, and the lamiophlomiol and quercetin content contained when brewing again later is extremely low,
Do not have medical value, virtually causes the waste of medicinal material.
Invention content
The purpose of the present invention is for existing problem, provide a kind of preparation method of slow-release lamiophlomis rotata medicine materical crude slice.
The present invention is achieved by the following technical solutions：
A kind of slow-release lamiophlomis rotata medicine materical crude slice, by weight component are as follows：10-20 parts of lamiophlomis rotata, 5-20 parts of Chinese aloe root, shellfish tooth 5-10
Part, 5-15 parts of Radix Notoginseng, 10-20 parts of phoenix-tail fern, 5-10 parts of rhizoma imperatae, 5-15 parts of hawthorn, 5-10 parts of radix bupleuri, 5-15 parts of mountain Cape jasmine, mulberry
10-30 parts 5-15 parts of leaf, 5-10 parts of the Fructus Sophorae, 10-20 parts of Inula britannica chinensis, sustained release of emulsion.
A kind of slow-release lamiophlomis rotata medicine materical crude slice, wherein sustained release emulsion component by weight is as follows：5-15 parts of ethyl acrylate, first
5-10 parts of base methyl acrylate, 5-10 parts of methylcellulose, 10-20 parts of sodium carboxymethyl starch, 5-20 parts of sodium alginate, Arab
5-20 parts of glue.
A kind of slow-release lamiophlomis rotata medicine materical crude slice, wherein the preparation method of sustained release emulsion is as follows：
1）5-15 parts of ethyl acrylate, 5-10 parts of methyl methacrylate is taken to be heated at high temperature after mixing, heating temperature 150-
It 200 DEG C, heating time 1-2h, waits for taking product spare after reaction；
2）5-20 parts of Arabic gum is taken, 5-10 parts of methylcellulose, 10-20 parts of sodium carboxymethyl starch is sequentially added, is put after mixing
Entering in blender and is stirred, rotating speed 500-800r/min, mixing time 10-30min are heated after to be mixed,
Heating temperature is 50-80 DEG C, and heating time 30-50min is cooled to room temperature after to be heated, and adjustment pH is 5.5-6.0, standby
With；
3）By 1）In product be added 2）In, 5-20 parts of sodium alginate is added after mixing, is put into blender and is stirred
It mixes, rotating speed 300-600r/min, mixing time 20-50min, it is 5-5.5 that pH is adjusted after to be mixed, you can one kind is made
It is sustained emulsion.
A kind of preparation method of slow-release lamiophlomis rotata medicine materical crude slice, specific preparation process are as follows：
1）10-20 parts of lamiophlomis rotata is taken, it is spare using being dried after medicinal material cleaning machine cleaning 10-20min；
2）5-15 parts of hawthorn, 5-10 parts of radix bupleuri, 5-15 parts of mulberry leaf, 5-15 parts of mountain Cape jasmine, 5-10 parts of the Fructus Sophorae, 10-20 parts of Inula britannica chinensis are taken,
30-50 parts of progress supersonic oscillations of 50-70% ethanol solutions, hunting power 300-500r/min, duration of oscillation are added after mixing
10-20min waits pouring into solution in container after vibrating, and adds same amount of ethyl alcohol and carries out supersonic oscillations, using same
The method of sample vibrates 2 times again, is evaporated under reduced pressure after the solution that 3 times vibrate is mixed, recycles ethyl alcohol, be then filtered, take
Filtrate is spare；
3）5-20 parts of Chinese aloe root, 5-10 points of shellfish tooth, 5-15 parts of Radix Notoginseng, 10-20 parts of phoenix-tail fern, 5-10 parts of rhizoma imperatae are taken, after mixing
30-70 parts of pure water is added, impregnates 20-40min, waits being heated to 150-180 DEG C using intense fire after impregnating, be used instead after boiling
80-120 DEG C of slow boiling, heating time 10-20min, concoction is poured into container, and 20-50 parts of pure water is added into the dregs of a decoction, is used
Same method is boiled medicine, and after the concoction cold filtration that 2 times are obtained, takes filtrate spare；
4）Take 1）In dry after lamiophlomis rotata lived with gauze wrapped, use 2）With 3）In filtrate mixing after be made 50-80ml spray
It drenches liquid and carries out intermittent spray, spray interval time 20-30min every time, spray time 3-5h is waited after spraying, and takes out yarn
The lamiophlomis rotata wrapped up in cloth, it is spare after air-drying；
5）By 4）In lamiophlomis rotata cut into 2-5cm slice, be put into vacuum tank and carry out oscillation rotation, power 200-
500r/min, duration of oscillation 20-40min are taken 10-30 parts of emulsion of sustained release in oscillatory process, are injected into using HP jetting pump
In container, injection pump pressure is set as 4-10Mpa；
6）Take out 5）In slice be placed in microwave generator and be dried, power 8-10KW, drying time 20-30min are waited for
It is fitted into after drying in vacuum packaging bag and can be prepared by a kind of slow-release lamiophlomis rotata medicine materical crude slice.
The present invention has the following advantages compared with prior art：
It has been investigated that containing abundant Flavonoid substances, the substance in hawthorn, radix bupleuri, mulberry leaf, mountain Cape jasmine, the Fructus Sophorae and Inula britannica chinensis
It can be effectively facilitated the activity of cell in lamiophlomis rotata, accelerate metabolism, to improve the content of lamiophlomiol and Quercetin,
Enhance the medical value of lamiophlomis rotata.Chinese aloe root, shellfish tooth, Radix Notoginseng, phoenix-tail fern and rhizoma imperatae can then improve the pharmacological property of lamiophlomis rotata, subtract
Gently generated because taking lamiophlomis rotata have a stomach upset, dizziness, the side effects such as palpitaition.
The copolymer that will be formed after ethyl acrylate and methyl methacrylate heating, with Arabic gum, methylcellulose
Sodium alginate is added after being mixed with sodium carboxymethyl starch, adjustment pH is 5.0-5.5, and a kind of sustained release emulsion is made.It will delay
It releases emulsion to be injected into vacuum tank using HP jetting pump, be come into full contact with lamiophlomis rotata slice, one is formed on surface after drying
Kind sustained release film.The sustained release film has a good water solubility in warm water, when sustained release film immersion in water, film it is molten
Swollen rate and integral dissolution rate increase, and differential solubility first increases and then decreases, with the increase of film soaking time in water,
So that film thickness is continuously increased, lead to originate dissolution rate continuously decreasing, slows down the molten of lamiophlomiol and Quercetin to reach
Go out speed so that lamiophlomis rotata medicine materical crude slice active constituent content after repeatedly brewing is still very high, still has fine medical value.
A kind of slow-release lamiophlomis rotata medicine materical crude slice provided by the invention has effects that repeatedly to brew repeatedly, keeps arriving for medicinal material abundant
Utilization, while the waste of medicinal material can also be reduced.
Specific implementation mode
With reference to specific implementation method, the present invention is described further.
Embodiment 1
A kind of slow-release lamiophlomis rotata medicine materical crude slice, by weight component are as follows：10 parts of lamiophlomis rotata, 5 parts of Chinese aloe root, 5 parts of shellfish tooth, Radix Notoginseng 5
Part, 5 parts of rhizoma imperatae, 5 parts of hawthorn, 5 parts of radix bupleuri, 5 parts of mountain Cape jasmine, 5 parts of mulberry leaf, 5 parts of the Fructus Sophorae, 10 parts of Inula britannica chinensis, is delayed at 10 parts of phoenix-tail fern
Release 10 parts of emulsion.
A kind of preparation method of slow-release lamiophlomis rotata medicine materical crude slice, is as follows：
1）5 parts of ethyl acrylate, 5 parts of methyl methacrylate is taken to be heated at high temperature after mixing, 150 DEG C of heating temperature, heating
Time 1h waits for taking product spare after reaction；
2）5 parts of Arabic gum is taken, 5 parts of methylcellulose, 10 parts of sodium carboxymethyl starch is sequentially added, is put into blender after mixing
It is stirred, rotating speed 500r/min, mixing time 10min is heated after to be mixed, and heating temperature is 50 DEG C, is added
Hot time 30min, is cooled to room temperature after to be heated, and adjustment pH is 5.5, spare；
3）By 1）In product be added 2）In, 5 parts of sodium alginate is added after mixing, is put into blender and is stirred,
Rotating speed is 300r/min, and mixing time 20min, it is 5 that pH is adjusted after to be mixed, you can a kind of sustained release emulsion is made；
4）10 parts of lamiophlomis rotata is taken, it is spare using being dried after medicinal material cleaning machine cleaning 10min；
5）5 parts of hawthorn, 5 parts of radix bupleuri, 5 parts of mulberry leaf, mountain Cape jasmine 5,5 parts of the Fructus Sophorae, 10 parts of Inula britannica chinensis are taken, it is molten that 50% ethyl alcohol is added after mixing
30 parts of progress supersonic oscillations of liquid, hunting power 300r/min, duration of oscillation 10min wait pouring into solution after vibrating
It in container, adds same amount of ethyl alcohol and carries out supersonic oscillations, vibrated again 2 times using same method, 3 times are vibrated molten
It is evaporated under reduced pressure after liquid mixing, recycles ethyl alcohol, be then filtered, take filtrate spare；
6）Take 5 parts of Chinese aloe root, shellfish tooth 5 to divide, 5 parts of Radix Notoginseng, 10 parts of phoenix-tail fern, 5 parts of rhizoma imperatae, after mixing be added 30 parts of pure water,
20min is impregnated, waits being heated to 150 DEG C using intense fire after impregnating, uses 80 DEG C, heating time 10min of slow boiling after boiling instead, it will
Concoction pours into container, and 20 parts of pure water is added into the dregs of a decoction, is boiled medicine using same method, the concoction that 2 times are obtained
After cold filtration, take filtrate spare；
7）Take 1）In dry after lamiophlomis rotata lived with gauze wrapped, use 2）With 3）In filtrate mixing after 50ml spray liquids are made
Intermittent spray is carried out, sprays interval time 20min every time, spray time 3h is waited after spraying, and is wrapped up in taking-up gauze
Lamiophlomis rotata, it is spare after air-drying；
8）By 4）In lamiophlomis rotata cut into 2cm slice, be put into vacuum tank and carry out oscillation rotation, power 200r/min,
Duration of oscillation 20min is taken 10 parts of emulsion of sustained release in oscillatory process, is injected into container using HP jetting pump, injection pump pressure
Power is set as 4Mpa；
9）Take out 5）In slice be placed in microwave generator and be dried, power 8KW, drying time 20min, knot to be dried
It is fitted into after beam in vacuum packaging bag and can be prepared by a kind of slow-release lamiophlomis rotata medicine materical crude slice.
Embodiment 2
A kind of slow-release lamiophlomis rotata medicine materical crude slice, by weight component are as follows：15 parts of lamiophlomis rotata, 15 parts of Chinese aloe root, 7 parts of shellfish tooth, Radix Notoginseng
10 parts, 15 parts of phoenix-tail fern, 7 parts of rhizoma imperatae, 10 parts of hawthorn, 7 parts of radix bupleuri, 10 parts of mountain Cape jasmine, 10 parts of mulberry leaf, 7 parts of the Fructus Sophorae, Inula britannica chinensis 15
20 parts part, sustained release of emulsion
A kind of preparation method of slow-release lamiophlomis rotata medicine materical crude slice, is as follows：
1）10 parts of ethyl acrylate, 7 parts of methyl methacrylate is taken to be heated at high temperature after mixing, 180 DEG C of heating temperature adds
Hot time 1.5h waits for taking product spare after reaction；
2）15 parts of Arabic gum is taken, 7 parts of methylcellulose, 15 parts of sodium carboxymethyl starch is sequentially added, blender is put into after mixing
In be stirred, rotating speed 600r/min, mixing time 20min are heated after to be mixed, heating temperature be 70 DEG C,
Heating time 40min is cooled to room temperature after to be heated, and adjustment pH is 5.8, spare；
3）By 1）In product be added 2）In, 15 parts of sodium alginate is added after mixing, is put into blender and is stirred,
Rotating speed is 500r/min, and mixing time 30min, it is 5.2 that pH is adjusted after to be mixed, you can a kind of sustained release emulsion is made；
4）15 parts of lamiophlomis rotata is taken, it is spare using being dried after medicinal material cleaning machine cleaning 15min；
5）10 parts of hawthorn, 7 parts of radix bupleuri, 10 parts of mulberry leaf, 10 parts of mountain Cape jasmine, 7 parts of the Fructus Sophorae, 15 parts of Inula britannica chinensis are taken, 60% second is added after mixing
40 parts of progress supersonic oscillations of alcoholic solution, hunting power 400r/min, duration of oscillation 15min are waited solution after vibrating
It pours into container, adds same amount of ethyl alcohol and carry out supersonic oscillations, vibrated again 2 times using same method, 3 times are vibrated
Solution mixing after be evaporated under reduced pressure, recycle ethyl alcohol, be then filtered, take filtrate spare；
6）Take 15 parts of Chinese aloe root, shellfish tooth 7 to divide, 10 parts of Radix Notoginseng, 15 parts of phoenix-tail fern, 7 parts of rhizoma imperatae, after mixing be added pure water 50
Part, 30min is impregnated, waits being heated to 170 DEG C using intense fire after impregnating, uses 100 DEG C of slow boiling, heating time after boiling instead
15min pours into concoction in container, and 30 parts of pure water is added into the dregs of a decoction, is boiled medicine using same method, and 2 times are obtained
After the concoction cold filtration arrived, take filtrate spare；
7）Take 1）In dry after lamiophlomis rotata lived with gauze wrapped, use 2）With 3）In filtrate mixing after 70ml spray liquids are made
Intermittent spray is carried out, sprays interval time 25min every time, spray time 4h is waited after spraying, and is wrapped up in taking-up gauze
Lamiophlomis rotata, it is spare after air-drying；
8）By 4）In lamiophlomis rotata cut into 3cm slice, be put into vacuum tank and carry out oscillation rotation, power 350r/min,
Duration of oscillation 30min is taken 20 parts of emulsion of sustained release in oscillatory process, is injected into container using HP jetting pump, injection pump pressure
Power is set as 7Mpa；
9）Take out 5）In slice be placed in microwave generator and be dried, power 9KW, drying time 25min, knot to be dried
It is fitted into after beam in vacuum packaging bag and can be prepared by a kind of slow-release lamiophlomis rotata medicine materical crude slice.
Embodiment 3
A kind of slow-release lamiophlomis rotata medicine materical crude slice, by weight component are as follows：20 parts of lamiophlomis rotata, 20 parts of Chinese aloe root, 10 parts of shellfish tooth, Radix Notoginseng 15
Part, 20 parts of phoenix-tail fern, 10 parts of rhizoma imperatae, 15 parts of hawthorn, 10 parts of radix bupleuri, 15 parts of mountain Cape jasmine, 15 parts of mulberry leaf, 10 parts of the Fructus Sophorae, Inula britannica chinensis
30 parts 20 parts, sustained release of emulsion.
A kind of preparation method of slow-release lamiophlomis rotata medicine materical crude slice, is as follows：
1）15 parts of ethyl acrylate, 10 parts of methyl methacrylate is taken to be heated at high temperature after mixing, 200 DEG C of heating temperature adds
Hot time 2h waits for taking product spare after reaction；
2）20 parts of Arabic gum is taken, 10 parts of methylcellulose, 20 parts of sodium carboxymethyl starch is sequentially added, blender is put into after mixing
In be stirred, rotating speed 800r/min, mixing time 30min are heated after to be mixed, heating temperature be 80 DEG C,
Heating time 50min is cooled to room temperature after to be heated, and adjustment pH is 6.0, spare；
3）By 1）In product be added 2）In, 20 parts of sodium alginate is added after mixing, is put into blender and is stirred,
Rotating speed is 600r/min, and mixing time 50min, it is 5.5 that pH is adjusted after to be mixed, you can a kind of sustained release emulsion is made；
4）20 parts of lamiophlomis rotata is taken, it is spare using being dried after medicinal material cleaning machine cleaning 20min；
5）15 parts of hawthorn, 10 parts of radix bupleuri, 15 parts of mulberry leaf, 15 parts of mountain Cape jasmine, 10 parts of the Fructus Sophorae, 20 parts of Inula britannica chinensis are taken, 70% is added after mixing
50 parts of progress supersonic oscillations of ethanol solution, hunting power 500r/min, duration of oscillation 20min, waiting will be molten after vibrating
Liquid pours into container, adds same amount of ethyl alcohol and carries out supersonic oscillations, is vibrated again 2 times using same method, 3 times are shaken
It is evaporated under reduced pressure after the solution mixing swung, recycles ethyl alcohol, be then filtered, take filtrate spare；
6）Take 20 parts of Chinese aloe root, shellfish tooth 10 to divide, 15 parts of Radix Notoginseng, 20 parts of phoenix-tail fern, 10 parts of rhizoma imperatae, after mixing be added pure water 70
Part, 40min is impregnated, waits being heated to 180 DEG C using intense fire after impregnating, uses 120 DEG C of slow boiling, heating time after boiling instead
20min pours into concoction in container, and 50 parts of pure water is added into the dregs of a decoction, is boiled medicine using same method, and 2 times are obtained
After the concoction cold filtration arrived, take filtrate spare；
7）Take 1）In dry after lamiophlomis rotata lived with gauze wrapped, use 2）With 3）In filtrate mixing after 80ml spray liquids are made
Intermittent spray is carried out, sprays interval time 30min every time, spray time 5h is waited after spraying, and is wrapped up in taking-up gauze
Lamiophlomis rotata, it is spare after air-drying；
8）By 4）In lamiophlomis rotata cut into 5cm slice, be put into vacuum tank and carry out oscillation rotation, power 500r/min,
Duration of oscillation 40min is taken 30 parts of emulsion of sustained release in oscillatory process, is injected into container using HP jetting pump, injection pump pressure
Power is set as 10Mpa；
9）Take out 5）In slice be placed in microwave generator and be dried, power 10KW, drying time 30min are to be dried
After be fitted into vacuum packaging bag and can be prepared by a kind of slow-release lamiophlomis rotata medicine materical crude slice.
Comparative example 1：Preparation method is substantially the same manner as Example 1, the difference is that not containing hawthorn.
Comparative example 2：Preparation method is substantially the same manner as Example 1, the difference is that not containing radix bupleuri.
Comparative example 3：Preparation method is substantially the same manner as Example 1, the difference is that not containing mulberry leaf.
Comparative example 4：Preparation method is substantially the same manner as Example 1, the difference is that not containing the Fructus Sophorae.
Comparative example 5：Preparation method is substantially the same manner as Example 1, the difference is that not containing Inula britannica chinensis.
Comparative example 6：Preparation method is substantially the same manner as Example 1, the difference is that not containing mountain Cape jasmine.
Comparative example 7：Preparation method is substantially the same manner as Example 1, the difference is that without containing sustained release emulsion.
Blank group 1：The lamiophlomis rotata medicine materical crude slice of prior art preparation.
Experimental example 1：The research of lamiophlomis rotata medicine materical crude slice pharmacological property.
Experimentation and result
The lamiophlomis rotata of Linzhi Area of Tibet is chosen, the lamiophlomis rotata medicine materical crude slice for using embodiment 1 and comparative example 1-6 to prepare respectively is ground into
It is powdered, No. three sieves are crossed, precision weighing 0.5g is put into conical flask with cover, accurate addition methanol 10ml, and conical flask with cover is close
It is honored as a queen, shakes up, weighed weight carries out sonic oscillation, and hunting power 500W, duration of oscillation 30min are waited weighed again after vibrating
Weight is supplied the weight of less loss with methanol, is shaken up, and with filtering with microporous membrane, takes and changes filtrate as test solution.Precision weighs
Lamiophlomiol reference substance and Quercetin reference substance, methanol is added, and that every 1ml is made is molten containing lamiophlomiol and each 0.5mg of Quercetin
Liquid, as a contrast product solution.It is accurate respectively to draw reference substance solution and each 10ml of test solution, inject high performance liquid chromatography
Instrument, calculates its content, and record result is as shown in Table 1：
Table one
As can be seen from Table I, lamiophlomiol and quercetin content divide in the lamiophlomis rotata medicine materical crude slice prepared using the method for embodiment 1
It Wei 3.56% and 2.45%, hence it is evident that lamiophlomis rotata higher than comparative example 1-6 and in lamiophlomis rotata medicine materical crude slice prepared by method that blank group provides
Element and quercetin content.It can be seen that lamiophlomis rotata medicine materical crude slice pharmacological property prepared by the method that embodiment 1 provides is best.
Experimental example 2：Lamiophlomis rotata medicine materical crude slice is sustained Journal of Sex Research.
Experimentation and result
The lamiophlomis rotata of Linzhi Area of Tibet is chosen, uses the method that embodiment 1, comparative example 6 and blank group 1 provide to prepare respectively only
The medicine materical crude slice of preparation is brewed 5-10h by medicine materical crude slice simply with 80 DEG C of warm water 100ml respectively, after to be brewed, takes out lamiophlomis rotata medicine materical crude slice
After drying, reuse same method and brew 4 times, by five times to concoction be respectively labeled as solution 1, solution 2, solution 3,
Solution 4 and solution 5.Lamiophlomiol and quercetin content in solution are measured using the method for the offer in experimental example 1, is as a result recorded
As shown in Table 2：
Table two
As can be seen from Table II, all 1.0% or more, Quercetin contains lamiophlomiol Content in the solution 1-3 in experimental example 1
Amount all in 0.70% or more, comparative example 6 and blank group 1 in addition in solution 1 lamiophlomiol and quercetin content it is higher other than, solution
Content in 2-5 is all very low, it can be seen that, lamiophlomis rotata medicine materical crude slice prepared by the method that experimental example 1 provides can delay when being brewed with warm water
The lamiophlomiol and Quercetin that On The Drug Release contains, extend lamiophlomis rotata medicine materical crude slice brews number.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
It transforms or replaces, should all cover within the scope of the present invention without what creative work was expected.
Claims (4)
1. a kind of preparation method of slow-release lamiophlomis rotata medicine materical crude slice, it is characterised in that component is as follows by weight：Lamiophlomis rotata 10-20
Part, 5-20 parts of Chinese aloe root, 5-10 parts of shellfish tooth, 5-15 parts of Radix Notoginseng, 10-20 parts of phoenix-tail fern, 5-10 parts of rhizoma imperatae, 5-15 parts of hawthorn,
10-30 parts 5-10 parts of radix bupleuri, 5-15 parts of mountain Cape jasmine, 5-15 parts of mulberry leaf, 5-10 parts of the Fructus Sophorae, 10-20 parts of Inula britannica chinensis, sustained release of emulsion.
2. a kind of preparation method of slow-release lamiophlomis rotata medicine materical crude slice as described in claim 1, which is characterized in that specific preparation process
It is as follows：
1）10-20 parts of lamiophlomis rotata is taken, it is spare using being dried after medicinal material cleaning machine cleaning 10-20min；
2）5-15 parts of hawthorn, 5-10 parts of radix bupleuri, 5-15 parts of mulberry leaf, 5-15 parts of mountain Cape jasmine, 5-10 parts of the Fructus Sophorae, 10-20 parts of Inula britannica chinensis are taken,
30-50 parts of progress supersonic oscillations of 50-70% ethanol solutions, hunting power 300-500r/min, duration of oscillation are added after mixing
10-20min waits pouring into solution in container after vibrating, and adds same amount of ethyl alcohol and carries out supersonic oscillations, using same
The method of sample vibrates 2 times again, is evaporated under reduced pressure after the solution that 3 times vibrate is mixed, recycles ethyl alcohol, be then filtered, take
Filtrate is spare；
3）5-20 parts of Chinese aloe root, 5-10 points of shellfish tooth, 5-15 parts of Radix Notoginseng, 10-20 parts of phoenix-tail fern, 5-10 parts of rhizoma imperatae are taken, after mixing
30-70 parts of pure water is added, impregnates 20-40min, waits being heated to 150-180 DEG C using intense fire after impregnating, be used instead after boiling
80-120 DEG C of slow boiling, heating time 10-20min, concoction is poured into container, and 20-50 parts of pure water is added into the dregs of a decoction, is used
Same method is boiled medicine, and after the concoction cold filtration that 2 times are obtained, takes filtrate spare；
4）Take 1）In dry after lamiophlomis rotata lived with gauze wrapped, use 2）With 3）In filtrate mixing after be made 50-80ml spray
It drenches liquid and carries out intermittent spray, spray interval time 20-30min every time, spray time 3-5h is waited after spraying, and takes out yarn
The lamiophlomis rotata wrapped up in cloth, it is spare after air-drying；
5）By 4）In lamiophlomis rotata cut into 2-5cm slice, be put into vacuum tank and carry out oscillation rotation, power 200-
500r/min, duration of oscillation 20-40min are taken 10-30 parts of emulsion of sustained release in oscillatory process, are injected into using HP jetting pump
In container, injection pump pressure is set as 4-10Mpa；
6）Take out 5）In slice be placed in microwave generator and be dried, power 8-10KW, drying time 20-30min are waited for
It is fitted into after drying in vacuum packaging bag and can be prepared by a kind of slow-release lamiophlomis rotata medicine materical crude slice.
3. a kind of preparation method of slow-release lamiophlomis rotata medicine materical crude slice as described in claim 1, which is characterized in that
The raw material component by weight for being sustained emulsion is as follows：5-15 parts of ethyl acrylate, 5-10 parts of methyl methacrylate, methyl
5-10 parts of cellulose, 10-20 parts of sodium carboxymethyl starch, 5-20 parts of sodium alginate, 5-20 parts of Arabic gum.
4. a kind of preparation method of slow-release lamiophlomis rotata medicine materical crude slice as claimed in claim 2, which is characterized in that be sustained the system of emulsion
Preparation Method is as follows：
1）5-15 parts of ethyl acrylate, 5-10 parts of methyl methacrylate is taken to be heated at high temperature after mixing, heating temperature 150-
It 200 DEG C, heating time 1-2h, waits for taking product spare after reaction；
2）5-20 parts of Arabic gum is taken, 5-10 parts of methylcellulose, 10-20 parts of sodium carboxymethyl starch is sequentially added, is put after mixing
Entering in blender and is stirred, rotating speed 500-800r/min, mixing time 10-30min are heated after to be mixed,
Heating temperature is 50-80 DEG C, and heating time 30-50min is cooled to room temperature after to be heated, and adjustment pH is 5.5-6.0, standby
With；
3）By 1）In product be added 2）In, 5-20 parts of sodium alginate is added after mixing, is put into blender and is stirred
It mixes, rotating speed 300-600r/min, mixing time 20-50min, it is 5-5.5 that pH is adjusted after to be mixed, you can one kind is made
It is sustained emulsion.
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