CN108431228B - Tlr抑制性寡核苷酸及其用途 - Google Patents

Tlr抑制性寡核苷酸及其用途

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Publication number
CN108431228B
CN108431228B CN201680076044.XA CN201680076044A CN108431228B CN 108431228 B CN108431228 B CN 108431228B CN 201680076044 A CN201680076044 A CN 201680076044A CN 108431228 B CN108431228 B CN 108431228B
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China
Prior art keywords
modified
oligonucleotides
oligonucleotide
phosphorothioate
base
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CN201680076044.XA
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English (en)
Chinese (zh)
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CN108431228A (zh
Inventor
江指永二
石田晃司
细泽拓美
奥山惠
小泷步
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SBI Biotech Co Ltd
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SBI Biotech Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/17—Immunomodulatory nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/53—Methods for regulating/modulating their activity reducing unwanted side-effects

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201680076044.XA 2015-12-25 2016-12-22 Tlr抑制性寡核苷酸及其用途 Active CN108431228B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2015255008 2015-12-25
JP2015-255008 2015-12-25
PCT/JP2016/088418 WO2017111045A1 (en) 2015-12-25 2016-12-22 Tlr inhibitory oligonucleotides and their use

Publications (2)

Publication Number Publication Date
CN108431228A CN108431228A (zh) 2018-08-21
CN108431228B true CN108431228B (zh) 2026-08-07

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Country Status (9)

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US (1) US10806749B2 (enExample)
EP (1) EP3394263B1 (enExample)
JP (1) JP7079495B2 (enExample)
KR (1) KR20180089531A (enExample)
CN (1) CN108431228B (enExample)
AU (1) AU2016375543A1 (enExample)
CA (1) CA3009154A1 (enExample)
IL (1) IL260193A (enExample)
WO (1) WO2017111045A1 (enExample)

Families Citing this family (5)

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Publication number Priority date Publication date Assignee Title
EP3468605A4 (en) 2016-06-08 2020-01-08 President and Fellows of Harvard College MANIPULATED VIRAL VECTOR TO REDUCE INDUCTION OF IGNITION AND IMMUNE REACTIONS
US10350307B2 (en) * 2017-09-18 2019-07-16 General Electric Company In vivo RNA or protein expression using double-stranded concatemeric DNA including phosphorothioated nucleotides
JP2021502381A (ja) 2017-11-08 2021-01-28 プレジデント アンド フェローズ オブ ハーバード カレッジ ウイルスベクター誘発性炎症反応を阻害するための組成物および方法
CN109266732A (zh) * 2018-09-13 2019-01-25 中山大学附属第医院 TLR7和TLR8作为IgA肾病预防治疗靶点的应用及TLR7的抑制剂及其应用
CN114569722B (zh) * 2022-03-07 2022-11-22 广州市妇女儿童医疗中心 抑制血小板焦亡的试剂在制备预防和/或治疗脓毒症的药物中的用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015120322A1 (en) * 2014-02-07 2015-08-13 Changchun Huapu Biotechnology Co., Ltd Inhibitory oligonucleotides for treating tumors

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JPS5011520A (enExample) 1973-05-31 1975-02-06
AU2003275776B2 (en) * 2002-11-08 2009-06-18 Jingang Medicine (Australia) Pty Ltd A method for optimising gene expression using synonymous codon optimisation
IL161579A0 (en) 2004-04-22 2004-09-27 Mor Research Applic Ltd ANTISENSE OLIGONUCLEOTIDES AGAINST cPLA2, COMPOSITIONS AND USES THEREOF
PL1866414T3 (pl) * 2005-03-31 2012-10-31 Calando Pharmaceuticals Inc Inhibitory podjednostki 2 reduktazy rybonukleotydowej i ich zastosowania
JP5011520B2 (ja) 2005-08-12 2012-08-29 国立大学法人 長崎大学 新規ヒト形質細胞様樹状細胞株
US8030289B2 (en) * 2008-08-06 2011-10-04 Changchun Huapu Biotechnology Co., Ltd. Oligonucleotide and use thereof
EP2154144B1 (en) 2008-08-06 2014-05-07 Changchun Huapu Biotechnology Co., Ltd. Oligonucleotides and use thereof
CN101696434A (zh) * 2009-10-27 2010-04-21 中国科学院过程工程研究所 β-聚苹果酸发酵新工艺
JP6106280B2 (ja) * 2012-11-29 2017-03-29 Ｓｂｉバイオテック株式会社 阻害性オリゴヌクレオチド及びその使用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015120322A1 (en) * 2014-02-07 2015-08-13 Changchun Huapu Biotechnology Co., Ltd Inhibitory oligonucleotides for treating tumors

Also Published As

Publication number Publication date
EP3394263B1 (en) 2025-02-26
AU2016375543A1 (en) 2018-06-28
US20190008888A1 (en) 2019-01-10
EP3394263A4 (en) 2019-08-21
IL260193A (en) 2018-07-31
JP2019500873A (ja) 2019-01-17
CN108431228A (zh) 2018-08-21
WO2017111045A1 (en) 2017-06-29
JP7079495B2 (ja) 2022-06-02
CA3009154A1 (en) 2017-06-29
KR20180089531A (ko) 2018-08-08
US10806749B2 (en) 2020-10-20
EP3394263A1 (en) 2018-10-31

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