CN108421030A - A kind of composition and its preparation method and application of enhancing pig disease resistance - Google Patents
A kind of composition and its preparation method and application of enhancing pig disease resistance Download PDFInfo
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- CN108421030A CN108421030A CN201810465472.2A CN201810465472A CN108421030A CN 108421030 A CN108421030 A CN 108421030A CN 201810465472 A CN201810465472 A CN 201810465472A CN 108421030 A CN108421030 A CN 108421030A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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Abstract
A kind of composition and its preparation method and application of enhancing pig disease resistance, score is composed of the following components by weight：10 30 parts of squalene, 20 40 parts of Magnolia cortex P.E, 50 70 parts of glutathione.A kind of composition that can enhance pig disease resistance of the present invention can be used for improving the immunity of pig, improve the anti-bacteria and anti-virus power of pig.Present invention process is simple, and the powder performance made of the present invention is stablized, of low cost.Squalene is a kind of nutriment, can improve immunity of organisms；Magnolia cortex P.E has the pharmacological actions such as anti-inflammatory, antibacterial, anti-oxidant, antitumor；Glutathione has wide spectrum detoxication, cannot be only used for drug, more can be used as the base-material of functional food, in the functional foods extensive use such as anti-aging, strengthen immunity, antitumor.
Description
Technical field
The invention belongs to fowl poultry immune field of medicaments, and in particular to it is a kind of enhancing pig disease resistance composition and its preparation
Methods and applications.
Background technology
In recent years, with the fast development of pig-breeding industry, cultivation scale constantly expands, and cultivation density is continuously improved, pig
Sick prevention and control situation is further severe, and swine disease type increases, and cause of disease variation is fast, and Epidemic Scope is wide, and the state of an illness is complicated, pig immunity level
Height becomes the key of swine disease prevention and control success or not.In this case, comprehensive measures for the prevention and control is only taken, it is immune by specification
Operation reinforces feeding management, pays attention to taking precautions against, and can just effectively improve immunocompetence of the live pig to disease.
In feed, drinking-water regularly health administration carry out disease prevention be effectively improve pig immunity method it
One, before and after sows farrowing, piglet puberty, the stages such as fattening period can all carry out health care administration, antibiosis is such as added in feed
It is known as the effect for significantly facilitating growth and development, improving premunition, but some countries have forbidden certain Antibiotic Additives at present
Use, therefore, using antibiotics additive when, should strictly control dosage, type, and to ensure enough durations stop medicine
Phase.In recent years, Chinese medicine additive gradually becomes new lover, not only has the effect of antibiotic, but also it is anti-to avoid long-time service
The adverse effect that raw element additive is brought.
Squalene also known as squalene are a kind of height unsaturation hydrocarbon compounds, initially isolated in black dogfish oil,
And the hydrocarbon compound that the mankind have found earliest from animal tissue.Squalene has infiltration, diffusion, bactericidal effect, either
It takes orally or coated on skin, a large amount of oxygen can be absorbed, reinforce cell metabolism, dispelling fatigue, it has also become definite functions
Active constituent, be widely used in functional food.
Cortex Magnoliae Officinalis is drying dry hide, root skin and the branch skin of Magnoliacea plant Cortex Magnoliae Officinalis.Due to acquisition position with processing method not
It is same to be divided into：Branch is plain, simple and unadorned, boots are plain and root is plain.Cortex Magnoliae Officinalis is a kind of common Chinese herbal medicine, and main component is aldehydes matter, main
If：Magnolol, honokiol, iso-agnolol, 8,9- dihydroxy dihydros honokiol, 8,9- dihydroxy -7- melonias
Honokiol, 8,9- dihydroxy dihydro magnolols etc. all have the effects that antibacterial, anti-oxidant, enhancing is immune.In addition also contain and wave
Hair oil and alkaloids.The place of production of Cortex Magnoliae Officinalis is very extensive, all quite extensive in Yunnan and In Middle And Lower Reaches of Changjiang River distribution, price
Also relatively cheap.
Glutathione is a kind of active kyrine with important physiological function, it is by glutamic acid, cysteine and glycine
It is condensed through peptide bond.Glutathione is distributed widely in body, played in many important biological phenomenas directly or
The effect connect, such as the synthesis of protein and DNA, the transport of substance, the activity of enzyme, metabolism and the protection of cell.It is
The prothetic group of many enzyme reactions can be used as the sulfydryl of antioxidant protection biomolecule, remove free radical excessive in vivo, participate in body
Interior tricarboxylic acid cycle and glycometabolism have the effects that removing toxic substances, slow down aging, prevent diabetes and cancer and dispelling fatigue.
Although there is the shortcomings that course for the treatment of long, slowly effect in Chinese medicine, but it meets that low medicine is residual, food consumption of green non-pollution becomes
Gesture, and as the feed addictive of illness raising early period pig immunity, protection effect is apparent.
Invention content
The technical issues of solution：The present invention provides a kind of composition and preparation method thereof of enhancing pig disease resistance and answers
With to reduce epidemic disease economic loss caused by raiser, improving the efficiency of feed utilization of pig.
Technical solution：A kind of composition of enhancing pig disease resistance, by weight score are composed of the following components：10-30 parts
Squalene, 20-40 parts of Magnolia cortex P.E, 50-70 parts of glutathione.
Preferably, squalene is 20 parts in above-mentioned composition, and Magnolia cortex P.E is 30 parts, and glutathione is 50 parts.
A kind of preparation method of the composition of enhancing pig disease resistance, includes the following steps：(1) by the weight proportion
Glutathione is heated to 200 DEG C, and stirring is allowed to melt completely, maintains temperature and stirs；(2) into the glutathione melted completely
The Magnolia cortex P.E of the weight proportion is added, stirs, until melting completely, maintains temperature, continues to stir 20min, be melted
Melt the mixture A of state；(3) stop heating, object A to be mixed is cooled to room temperature, is crushed into powder, is sieved with 100 mesh sieve, and mixing is made
Object A powder；(4) squalene is added to Sprayable in the mixture A powder under stirring condition, is mixed in a kettle later
1h is to get the composition.
Preferably, the mixing speed described in all steps is 200r/min.
Above-mentioned composition is preparing the application in enhancing pig disease resistance drug.
Advantageous effect：A kind of composition that can enhance pig disease resistance of the present invention can be used for improving the immunity of pig, carry
The anti-bacteria and anti-virus power of high pig.Present invention process is simple, and the powder performance made of the present invention is stablized, of low cost.Squalene
It is a kind of nutriment, immunity of organisms can be improved；Magnolia cortex P.E has the pharmacology such as anti-inflammatory, antibacterial, anti-oxidant, antitumor
Effect；Glutathione has wide spectrum detoxication, cannot be only used for drug, more can be used as the base-material of functional food, is delaying
The functional foods extensive use such as aging, strengthen immunity, antitumor.
Specific implementation mode
Embodiments of the present invention are described in detail below in conjunction with embodiment.Squalene is purchased from Guangzhou Ke You chemical industry
Science and Technology Ltd., the Magnolia cortex P.E are purchased from the Xi'an bio tech ltd Ming Ze, and the glutathione is purchased from Henan
Tian Xing food additives Co., Ltd.
Embodiment 1
A kind of Chinese and western medicinal composition of enhancing pig disease resistance, in parts by weight by 10 parts of squalenes, 20 parts of Cortex Magnoliae Officinalis extractions
It is formed with 70 parts of glutathione.Preparation method includes the following steps：(1) glutathione of the weight proportion is heated to 200
DEG C, stirring is allowed to melt completely, maintains temperature and stirs；(2) weight proportion is added into the glutathione melted completely
Magnolia cortex P.E, stirring maintains temperature until melt completely, continues to stir 20min, obtain the mixture A of molten state；(3)
Stop heating, object A to be mixed is cooled to room temperature, is crushed into powder, is sieved with 100 mesh sieve, and mixture A powder is made；(4) by squalene
It is added to Sprayable in the mixture A powder under stirring condition, mixes 1h in a kettle later to get the combination
Object.Mixing speed described in above-mentioned all steps is 200r/min.
Embodiment 2
A kind of Chinese and western medicinal composition of enhancing pig disease resistance, in parts by weight by 10 parts of squalenes, 30 parts of Cortex Magnoliae Officinalis extractions
Object and 60 parts of glutathione compositions.Preparation process is the same as embodiment 1.
Embodiment 3
A kind of Chinese and western medicinal composition of enhancing pig disease resistance, in parts by weight by 10 parts of squalenes, 40 parts of Cortex Magnoliae Officinalis extractions
Object and 50 parts of glutathione compositions.Preparation process is the same as embodiment 1.
Embodiment 4
A kind of Chinese and western medicinal composition of enhancing pig disease resistance, in parts by weight by 20 parts of squalenes, 20 parts of Cortex Magnoliae Officinalis extractions
Object and 60 parts of glutathione compositions.Preparation process is the same as embodiment 1.
Embodiment 5
A kind of Chinese and western medicinal composition of enhancing pig disease resistance, in parts by weight by 20 parts of squalenes, 30 parts of Cortex Magnoliae Officinalis extractions
Object and 50 parts of glutathione compositions.Preparation process is the same as embodiment 1.
Embodiment 6
A kind of Chinese and western medicinal composition of enhancing pig disease resistance, in parts by weight by 30 parts of squalenes, 20 parts of Cortex Magnoliae Officinalis extractions
Object and 50 parts of glutathione compositions.Preparation process is the same as embodiment 1.
Test example 1
Choose Taizhou pig farm piglet and each 325 of Adult Pig, piglet and Adult Pig be divided into test group 1, test group 2,
Test group 3, test group 4, test group 5, test group 6, test group 7, test group 8, test group 9, test group 10, test group 11, examination
Group 12 and control group are tested, every group 50, piglet 25, Adult Pig 25 divides circle raising.Test group 1-6 uses the present invention real respectively
It applies composition prepared by 1-6 and carries out feeding, test group 7 carries out feeding with squalene, and test group 8 is fed with Magnolia cortex P.E
Food, test group 9 carry out feeding with glutathione, and the squalene of test group 10 carries out feeding with Magnolia cortex P.E (respectively accounting for 50%),
The squalene of test group 11 carries out feeding, test group 12 Magnolia cortex P.E and glutathione with glutathione (respectively accounting for 50%)
(respectively accounting for 50%) carries out feeding, and control group is not administered, and test pig is kept environment consistent with feeding management, taken by personal management
It is freely eaten and drinks water, during experiment, daily disinfection is normally carried out.
Specific packet transaction is as shown in table 1.
Table 1 is grouped and processing
| Group | Test pig's head number | Dosage (mg/kg.bw) | Processing mode |
| Piglets group 1 | 25 | 5 | Mixed feeding is administered |
| Piglets group 2 | 25 | 5 | Mixed feeding is administered |
| Piglets group 3 | 25 | 5 | Mixed feeding is administered |
| Piglets group 4 | 25 | 5 | Mixed feeding is administered |
| Piglets group 5 | 25 | 5 | Mixed feeding is administered |
| Piglets group 6 | 25 | 5 | Mixed feeding is administered |
| Piglets group 7 | 25 | 5 | Mixed feeding is administered |
| Piglets group 8 | 25 | 5 | Mixed feeding is administered |
| Piglets group 9 | 25 | 5 | Mixed feeding is administered |
| Piglets group 10 | 25 | 5 | Mixed feeding is administered |
| Piglets group 11 | 25 | 5 | Mixed feeding is administered |
| Piglets group 12 | 25 | 5 | Mixed feeding is administered |
| Piglet control group | 25 | 0 | It is not administered |
| Adult Pig test group 1 | 25 | 12 | Mixed feeding is administered |
| Adult Pig test group 2 | 25 | 12 | Mixed feeding is administered |
| Adult Pig test group 3 | 25 | 12 | Mixed feeding is administered |
| Adult Pig test group 4 | 25 | 12 | Mixed feeding is administered |
| Adult Pig test group 5 | 25 | 12 | Mixed feeding is administered |
| Adult Pig test group 6 | 25 | 12 | Mixed feeding is administered |
| Adult Pig test group 7 | 25 | 12 | Mixed feeding is administered |
| Adult Pig test group 8 | 25 | 12 | Mixed feeding is administered |
| Adult Pig test group 9 | 25 | 12 | Mixed feeding is administered |
| Adult Pig test group 10 | 25 | 12 | Mixed feeding is administered |
| Adult Pig test group 11 | 25 | 12 | Mixed feeding is administered |
| Adult Pig test group 12 | 25 | 12 | Mixed feeding is administered |
| Adult Pig control group | 25 | 0 | It is not administered |
1. medication
3 times/d, 30d is used in conjunction.Control group is without any drug-treated.
2. observation index
The breath state of piglet and Adult Pig during observation medication breathes, the clinical indices such as diarrhea, while observing morbid pig
Head number, and observe the state of an illness of sick pig whether there is or not recurrence after drug withdrawal 7d or occur dead.
3. therapeutic effect criterion
1. effective：Temperature of pig body is normal, no diarrhea, and breathing is normal, no oedema, and spirit, appetite are normal；
2. improving：Temperature of pig body is normal, no diarrhea, has mild respiratory symptom, spirit, appetite normal；
3. invalid：There is exception in temperature of pig body, has diarrhea, there is respiratory symptom, loses the appetite, weight loss.
It cures number revolution of becoming reconciled and adds up to total significant figure, invalid number includes death toll.
2 treatment results of table are analyzed
As seen from the experiment, the effective percentage of test group 1-6 is much larger than the effective percentage of other groups, and test group 10-12's has
Efficiency is more than the effective percentage of test group 7-9 and control group, and the effective percentage of test group 5 is highest in all groups, illustrates this hair
Bright composition can improve the immunity of piglet and Adult Pig, and the effect of composition will be much better than its component and individually treat
Effect.In addition dose can suitably be increased according to actual conditions, to reach optimum efficiency.
Test example 2
Piglet and each 325 of the Adult Pig for mild diarrhea or respiratory symptom occur are chosen, piglet and Adult Pig are divided into
Test group 1, test group 2, test group 3, test group 4, test group 5, test group 6, test group 7, test group 8, test group 9, experiment
Group 10, test group 11, test group 12 and control group, every group 50, piglet 25, Adult Pig 25, point circle raising.Test group 1-
6 carry out feeding with 1-6 of the embodiment of the present invention compositions prepared respectively, and test group 7 carries out feeding with squalene, and test group 8 is used
Magnolia cortex P.E carries out feeding, and test group 9 carries out feeding with glutathione, and test group 10 is (each with Magnolia cortex P.E with squalene
50%) progress feeding is accounted for, the squalene of test group 11 carries out feeding with glutathione (respectively accounting for 50%), and test group 12 is carried with Cortex Magnoliae Officinalis
Object is taken to carry out feeding with glutathione (respectively accounting for 50%), control group is not administered, and test pig keeps environment and raising by personal management
Management is consistent, takes free choice feeding and drinking-water, during experiment, daily disinfection is normally carried out.
Specific packet transaction is as shown in table 3.
Table 3 is grouped and processing
1. medication
3 times/d, 30d is used in conjunction.Control group is without any drug-treated.
2. observation index
The breath state of piglet and Adult Pig during observation medication breathes, the clinical indices such as diarrhea, while observing morbid pig
Head number, and observe the state of an illness of sick pig whether there is or not recurrence after drug withdrawal 7d or occur dead.
3. therapeutic effect criterion
1. effective：Temperature of pig body is normal, no diarrhea, and breathing is normal, no oedema, and spirit, appetite are normal；
2. improving：Temperature of pig body is normal, no diarrhea, has mild respiratory symptom, spirit, appetite normal；
3. invalid：There is exception in temperature of pig body, has diarrhea, there is respiratory symptom, loses the appetite, weight loss.
4 treatment results of table are analyzed
By being tested above it is found that the effective percentage of test group 1-6 is much larger than the effective percentage of other groups, test group 10-12's has
Efficiency is more than the effective percentage of test group 7-9 and control group, and the effective percentage of test group 5 is highest in all groups, illustrates this hair
Bright composition for piglet and the Adult Pig of doubtful illness be improved immunity the effect of, and significant effect, and combining
The effect of object, will be much better than the independent curative effect of its component.Dose can suitably be increased according to actual conditions, to reach optimum efficiency.
Claims (5)
1. a kind of composition of enhancing pig disease resistance, it is characterised in that score is composed of the following components by weight：10-30 parts
Squalene, 20-40 parts of Magnolia cortex P.E, 50-70 parts of glutathione.
2. enhancing the composition of pig disease resistance according to claim 1, it is characterised in that the squalene is 20 parts, Cortex Magnoliae Officinalis
Extract is 30 parts, and glutathione is 50 parts.
3. enhancing the preparation method of the composition of pig disease resistance described in claims 1 or 2, it is characterised in that including following step
Suddenly：
Glutathione by weight ratio is heated to 200 DEG C, stirring is allowed to melt completely, maintains temperature and stirs；
The Magnolia cortex P.E of the weight proportion is added into the glutathione melted completely, stirs, until melting completely, maintains
Temperature continues to stir 20 min, obtains the mixture A of molten state；
Stop heating, object A to be mixed is cooled to room temperature, is crushed into powder, is sieved with 100 mesh sieve, and mixture A powder is made；
Squalene is added to Sprayable in the mixture A powder under stirring condition, later in a kettle mixing 1h to get
The composition.
4. the preparation method of the composition of enhancing pig disease resistance according to claim 3, it is characterised in that in preparation process
The mixing speed is 200 r/min.
5. composition described in claims 1 or 2 is preparing the application in enhancing pig disease resistance drug.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810465472.2A CN108421030A (en) | 2018-05-16 | 2018-05-16 | A kind of composition and its preparation method and application of enhancing pig disease resistance |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810465472.2A CN108421030A (en) | 2018-05-16 | 2018-05-16 | A kind of composition and its preparation method and application of enhancing pig disease resistance |
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| CN108421030A true CN108421030A (en) | 2018-08-21 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810465472.2A Pending CN108421030A (en) | 2018-05-16 | 2018-05-16 | A kind of composition and its preparation method and application of enhancing pig disease resistance |
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| Country | Link |
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| CN (1) | CN108421030A (en) |
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2018
- 2018-05-16 CN CN201810465472.2A patent/CN108421030A/en active Pending
Non-Patent Citations (5)
| Title |
|---|
| TING DU等: "Glutathione-Capped Ag 2 S Nanoclusters Inhibit Coronavirus Proliferation through Blockage of Viral RNA Synthesis and Budding", 《ACS APPL MATER INTERFACES》 * |
| 张延涛: "谷胱甘肽对断奶仔猪生长与免疫的影响", 《万方数据库，华南农业大学硕士学位论文》 * |
| 焦炳华等主编: "《中国海洋生化学术会议论文荟萃》", 31 May 2004 * |
| 郑梦奇等: "育肥猪日粮中添加谷胱甘肽的使用效果试验", 《畜牧与兽医》 * |
| 郝庆红等: "厚朴中清除氧自由基主要有限成分的确定", 《河北大学学报（自然科学版）》 * |
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