CN108421015A - 一种用于祛湿、止痛的外用贴剂 - Google Patents
一种用于祛湿、止痛的外用贴剂 Download PDFInfo
- Publication number
- CN108421015A CN108421015A CN201810301601.4A CN201810301601A CN108421015A CN 108421015 A CN108421015 A CN 108421015A CN 201810301601 A CN201810301601 A CN 201810301601A CN 108421015 A CN108421015 A CN 108421015A
- Authority
- CN
- China
- Prior art keywords
- temperature
- pain
- rheumatism
- injury
- added
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K31/125—Camphor; Nuclear substituted derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明涉及用于祛湿、止痛的外用贴剂,可有效解决现有膏贴剂患者贴敷时出现的粘毛、刺激、过敏反应的问题,其解决的技术方案是,该贴剂由无纺布、防粘纸和伤湿祛痛膏构成,所述的伤湿祛痛膏是由以下重量百分比计的:天然橡胶10‑20%、合成橡胶10‑20%、液状石蜡10‑20%、黄凡士林10‑15%、羊毛脂10‑15%、氧化硅5‑10%、松香衍生物10‑20%、抗氧剂0.1‑0.3%、药物浸膏12‑18%、薄荷脑1‑3%、冰片1‑3%、樟脑0.5‑1.5%和水杨酸甲酯1‑3%制成,本发明组方新颖独特,特别是采用新型基质作为药物载体,有效解决了现有伤湿祛痛膏贴导致的粘毛、刺激及致敏性而导致的患者贴敷后撕掉时疼痛难忍问题,是伤湿祛痛膏贴剂上的创新。
Description
技术领域
本发明涉及医药领域,特别是一种用于祛湿、止痛的外用贴剂。
背景技术
目前,国内生产的伤湿祛痛膏产品使用的传统基质原料配方中,持粘力太强,容易粘毛,撕掉时疼痛难忍,且易引起皮肤过敏。由于天然橡胶等基质的持粘力太强,以及刺激和致敏性,导致消费者贴敷后存在着撕掉时疼痛难忍,不利于病人的使用和身体健康,其原因在于传统基质中使用大量的有机溶剂和天然橡胶,在制备烘干过程有机溶剂又无法收集而完全蒸发掉,造成大量能源浪费,天然橡胶内聚力太大,和皮肤之间的粘合性太强,且含有高蛋白类物质,易导致皮肤过敏。因此,对现有伤湿祛痛膏的基质进行改进和创新,从而制备出新型的伤湿祛痛膏贴剂是目前亟需解决的技术问题。
发明内容
针对上述情况,为解决现有技术之缺陷,本发明之目的就是提供一种用于祛湿、止痛的外用贴剂,可有效解决现有膏贴剂患者贴敷时出现的粘毛、刺激、过敏反应的问题。
本发明解决的技术方案是,该贴剂由无纺布、防粘纸和伤湿祛痛膏构成,所述的伤湿祛痛膏是由以下重量百分比计的:天然橡胶10-20%、合成橡胶10-20%、液状石蜡10-20%、黄凡士林10-15%、羊毛脂10-15%、氧化硅5-10%、松香衍生物10-20%、抗氧剂0.1-0.3%、药物浸膏12-18%、薄荷脑1-3%、冰片1-3%、樟脑0.5-1.5%和水杨酸甲酯1-3%制成,先将天然橡胶、合成橡胶、松香衍生物、抗氧剂混合在一起,搅拌均匀(目测无明显橡胶颗粒),在温度110~140℃时,加入氧化硅继续搅拌,在温度110~140℃时,加入液状石蜡、黄凡士林、羊毛脂继续搅拌,再在温度100~130℃时,加入混合药物,至搅拌均匀,降温至温度80~100℃时,涂布在无纺布上,并覆盖防粘纸,切片,即得;所述的合成橡胶是指苯乙烯-丁二烯-苯乙烯嵌段共聚物、萜烯树脂、松香甘油酯及衍生物、聚异丁烯的一种或两种以上组合物,所述的药物浸膏为以下重量百分比计的:生川乌8.06%、生草乌8.06%、麻黄8.06%、苍术16.11%、当归16.11%、白芷10.25%、干姜21.71%、山柰6.54%、八角茴香5.10%共9味粉碎成细粉,用85%乙醇回流三次,每次1.5小时,合并提取液,回收乙醇,浓缩至在55~60℃时相对密度为1.16~1.21的浸膏;所述的混合药物为药物浸膏、薄荷脑、冰片、樟脑、水杨酸甲酯混合在一起制成。
本发明组方新颖独特,特别是采用新型基质作为药物载体,有效解决了现有伤湿祛痛膏贴导致的粘毛、刺激及致敏性而导致的患者贴敷后撕掉时疼痛难忍问题,非常有利于患者的使用和身体健康,是伤湿祛痛膏贴剂上的创新。
具体实施方式
以下结合实施例对本发明的具体实施方式作进一步详细说明。
实施例 1
本发明在具体实施时,该贴剂由无纺布、防粘纸和伤湿祛痛膏构成,所述的伤湿祛痛膏可由以下重量百分比计的:天然橡胶12.8%、合成橡胶13%、液状石蜡15%、黄凡士林10%、羊毛脂10%、氧化硅6%、松香衍生物11%、抗氧剂0.2%、药物浸膏17%、薄荷脑1.7%、冰片1.3%、樟脑0.7%和水杨酸甲酯1.3%制成,先将天然橡胶、合成橡胶、松香衍生物、抗氧剂混合在一起,搅拌均匀,在温度110℃时,加入氧化硅继续搅拌,在温度110℃时,加入液状石蜡、黄凡士林、羊毛脂继续搅拌,再在温度100℃时,加入混合药物,至搅拌均匀,降温至温度80℃时,涂布在无纺布上,并覆盖防粘纸,切片,即得;制膏有效时间控制在360±30分钟。
实施例 2
本发明在具体实施时,该贴剂由无纺布、防粘纸和伤湿祛痛膏构成,所述的伤湿祛痛膏还可由以下重量百分比计的:天然橡胶8%、合成橡胶15%、液状石蜡10%、黄凡士林12%、羊毛脂11%、氧化硅6.2%、松香衍生物11%、抗氧剂0.3%、药物浸膏16%、薄荷脑3%、冰片3%、樟脑1.5%和水杨酸甲酯3%制成,先将天然橡胶、合成橡胶、松香衍生物、抗氧剂混合在一起,搅拌均匀,在温度125℃时,加入氧化硅继续搅拌,在温度125℃时,加入液状石蜡、黄凡士林、羊毛脂继续搅拌,再在温度125℃时,加入混合药物,至搅拌均匀,降温至温度95℃时,涂布在无纺布上,并覆盖防粘纸,切片,即得;制膏有效时间控制在360±30分钟。
实施例 3
本发明在具体实施时,该贴剂由无纺布、防粘纸和伤湿祛痛膏构成,所述的伤湿祛痛膏还可由以下重量百分比计的:天然橡胶9.1%、合成橡胶12%、液状石蜡18%、黄凡士林12%、羊毛脂10%、氧化硅5%、松香衍生物10%、抗氧剂0.1%、药物浸膏15.5%、薄荷脑2.5%、冰片2.4%、樟脑1.2%和水杨酸甲酯2.2%制成,先将天然橡胶、合成橡胶、松香衍生物、抗氧剂混合在一起,搅拌均匀,在温度140℃时,加入氧化硅继续搅拌,在温度140℃时,加入液状石蜡、黄凡士林、羊毛脂继续搅拌,再在温度130℃时,加入混合药物,至搅拌均匀,降温至温度100℃时,涂布在无纺布上,并覆盖防粘纸,切片,即得;制膏有效时间控制在360±30分钟。
由上述本发明技术方案可以看出,本发明与现有伤湿祛痛膏贴剂相比,最大的区别在于,采用新型基质作为药物载体,有效克服了传统基质所带来的粘毛、刺激性、过敏性问题,明显优于现有伤湿祛痛膏贴剂,从根本上解决了伤湿祛痛膏贴剂存在的粘毛、刺激性、过敏性问题,非常有利于患者贴敷和身体健康,经对 186 名患者适用,随机分为3 组,每组62 人,试验组采用本发明的祛湿、止痛的外用贴剂,对比组采用两组不同的现有伤湿祛痛膏贴剂,有关实验资料如下:
不同伤湿祛痛膏贴剂粘毛程度试验结果
组 别 | 平均分值 | 粘毛程度 |
本发明祛湿、止痛的外用贴剂 | 0 | 不粘毛(<0.5) |
伤湿祛痛膏(修正药业集团股份有限公司) | 1.5 | 轻微粘毛(<2.0) |
伤湿祛痛膏(广东粤威制药有限公司) | 3.0 | 严重粘毛(>2.0) |
不同伤湿祛痛膏贴剂对皮肤过敏性性试验结果
组 别 | 致敏发生率(%) | 皮肤致敏性结果 |
本发明祛湿、止痛的外用贴剂 | 2 | 弱致敏性(0-10%) |
伤湿祛痛膏(修正药业集团股份有限公司) | 22 | 轻度致敏性(20-30%) |
伤湿祛痛膏(广东粤威制药有限公司) | 26 | 轻度致敏性(20-30%) |
由上表可以清楚的看出,本发明不粘毛,无刺激性,而致敏性也大大降低,几乎无过敏性,从根本上解决了伤湿祛痛膏存在的粘毛问题,刺激性、过敏性问题。
总之,实验资料清楚表明,本发明与现有技术相比,提供了一种由新型基质载体制成的祛湿、止痛的外用贴剂,有效的解决患者贴敷粘毛问题和刺激过敏反应,这种以新型基质作为药物载体,从根本上解决粘毛问题,皮肤刺激性过敏性的问题,明显优于现有的伤湿祛痛膏,是伤湿祛痛膏外用贴剂上的一大创新,经济和社会效益显著。
Claims (4)
1.一种用于祛湿、止痛的外用贴剂,其特征在于,该贴剂由无纺布、防粘纸和伤湿祛痛膏构成,所述的伤湿祛痛膏是由以下重量百分比计的:天然橡胶10-20%、合成橡胶10-20%、液状石蜡10-20%、黄凡士林10-15%、羊毛脂10-15%、氧化硅5-10%、松香衍生物10-20%、抗氧剂0.1-0.3%、药物浸膏12-18%、薄荷脑1-3%、冰片1-3%、樟脑0.5-1.5%和水杨酸甲酯1-3%制成,先将天然橡胶、合成橡胶、松香衍生物、抗氧剂混合在一起,搅拌均匀,在温度110~140℃时,加入氧化硅继续搅拌,在温度110~140℃时,加入液状石蜡、黄凡士林、羊毛脂继续搅拌,再在温度100~130℃时,加入混合药物,至搅拌均匀,降温至温度80~100℃时,涂布在无纺布上,并覆盖防粘纸,切片,即得;所述的合成橡胶是指苯乙烯-丁二烯-苯乙烯嵌段共聚物、萜烯树脂、松香甘油酯及衍生物、聚异丁烯的一种或两种以上组合物,所述的药物浸膏为以下重量百分比计的:生川乌8.06%、生草乌8.06%、麻黄8.06%、苍术16.11%、当归16.11%、白芷10.25%、干姜21.71%、山柰6.54%、八角茴香5.10%共9味粉碎成细粉,用85%乙醇回流三次,每次1.5小时,合并提取液,回收乙醇,浓缩至在55~60℃时相对密度为1.16~1.21的浸膏;所述的混合药物为药物浸膏、薄荷脑、冰片、樟脑、水杨酸甲酯混合在一起制成。
2.根据权利要求1所述的用于祛湿、止痛的外用贴剂,其特征在于,该贴剂由无纺布、防粘纸和伤湿祛痛膏构成,所述的伤湿祛痛膏可由以下重量百分比计的:天然橡胶12.8%、合成橡胶13%、液状石蜡15%、黄凡士林10%、羊毛脂10%、氧化硅6%、松香衍生物11%、抗氧剂0.2%、药物浸膏17%、薄荷脑1.7%、冰片1.3%、樟脑0.7%和水杨酸甲酯1.3%制成,先将天然橡胶、合成橡胶、松香衍生物、抗氧剂混合在一起,搅拌均匀,在温度110℃时,加入氧化硅继续搅拌,在温度110℃时,加入液状石蜡、黄凡士林、羊毛脂继续搅拌,再在温度100℃时,加入混合药物,至搅拌均匀,降温至温度80℃时,涂布在无纺布上,并覆盖防粘纸,切片,即得。
3.根据权利要求1所述的用于祛湿、止痛的外用贴剂,其特征在于,该贴剂由无纺布、防粘纸和伤湿祛痛膏构成,所述的伤湿祛痛膏还可由以下重量百分比计的:天然橡胶8%、合成橡胶15%、液状石蜡10%、黄凡士林12%、羊毛脂11%、氧化硅6.2%、松香衍生物11%、抗氧剂0.3%、药物浸膏16%、薄荷脑3%、冰片3%、樟脑1.5%和水杨酸甲酯3%制成,先将天然橡胶、合成橡胶、松香衍生物、抗氧剂混合在一起,搅拌均匀,在温度125℃时,加入氧化硅继续搅拌,在温度125℃时,加入液状石蜡、黄凡士林、羊毛脂继续搅拌,再在温度125℃时,加入混合药物,至搅拌均匀,降温至温度95℃时,涂布在无纺布上,并覆盖防粘纸,切片,即得。
4.根据权利要求1所述的用于祛湿、止痛的外用贴剂,其特征在于,该贴剂由无纺布、防粘纸和伤湿祛痛膏构成,所述的伤湿祛痛膏还可由以下重量百分比计的:天然橡胶9.1%、合成橡胶12%、液状石蜡18%、黄凡士林12%、羊毛脂10%、氧化硅5%、松香衍生物10%、抗氧剂0.1%、药物浸膏15.5%、薄荷脑2.5%、冰片2.4%、樟脑1.2%和水杨酸甲酯2.2%制成,先将天然橡胶、合成橡胶、松香衍生物、抗氧剂混合在一起,搅拌均匀,在温度140℃时,加入氧化硅继续搅拌,在温度140℃时,加入液状石蜡、黄凡士林、羊毛脂继续搅拌,再在温度130℃时,加入混合药物,至搅拌均匀,降温至温度100℃时,涂布在无纺布上,并覆盖防粘纸,切片,即得。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810301601.4A CN108421015A (zh) | 2018-04-04 | 2018-04-04 | 一种用于祛湿、止痛的外用贴剂 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810301601.4A CN108421015A (zh) | 2018-04-04 | 2018-04-04 | 一种用于祛湿、止痛的外用贴剂 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN108421015A true CN108421015A (zh) | 2018-08-21 |
Family
ID=63160641
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201810301601.4A Pending CN108421015A (zh) | 2018-04-04 | 2018-04-04 | 一种用于祛湿、止痛的外用贴剂 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN108421015A (zh) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101485876A (zh) * | 2009-02-12 | 2009-07-22 | 修正药业集团股份有限公司 | 一种祛风湿、止痛的中药贴膏剂的制备方法 |
-
2018
- 2018-04-04 CN CN201810301601.4A patent/CN108421015A/zh active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101485876A (zh) * | 2009-02-12 | 2009-07-22 | 修正药业集团股份有限公司 | 一种祛风湿、止痛的中药贴膏剂的制备方法 |
Non-Patent Citations (1)
Title |
---|
刘齐等: "中药橡胶膏剂致敏因素分析与对策", 《中国医院药学杂志》 * |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN108498345B (zh) | 一种凝胶贴剂及其制备方法 | |
CN103316078B (zh) | 一种舒眠降温贴剂及其制备方法 | |
CN102939075A (zh) | 经皮吸收促进剂及其外部皮肤制剂 | |
CN104606656A (zh) | 一种中药橡胶膏剂膏料的制备工艺 | |
CN106822326B (zh) | 中药贴剂颈痛贴膏及其制备方法 | |
CN103272133A (zh) | 一种用于消炎止血的发酵物的制备方法 | |
CN108421015A (zh) | 一种用于祛湿、止痛的外用贴剂 | |
CN102755595A (zh) | 骨伤药贴及制备方法 | |
CN201658672U (zh) | 一种改进型狗皮膏药 | |
CN101020019A (zh) | 狗皮膏(巴布剂)及其制备方法 | |
CN105797100B (zh) | 活血止痛压敏胶贴及其制备方法 | |
CN106822049A (zh) | 新型化药贴剂酮洛芬贴片及其制备方法 | |
CN105363021A (zh) | 促进创面愈合的凝胶 | |
CN104840449B (zh) | 一种药物贴剂及其制备方法 | |
CN1251668C (zh) | 中药贴膏基质、使用该基质的中药贴膏及它们的制备方法 | |
CN102940777A (zh) | 一种止咳利咽巴布剂及其制备方法 | |
CN104288278B (zh) | 美洲大蠊与地榆的联合用药用途 | |
CN112386569A (zh) | 一种中药凝胶辅料及其应用 | |
WO2020194220A1 (en) | Sleep aid transdermal patch and its process of preparation | |
CN109675088A (zh) | 一种耐老化抗菌医用压敏胶黏剂及其制备方法 | |
CN106511799A (zh) | 一种退热贴用高分子凝胶及其制备方法 | |
CN110251638B (zh) | 一种治疗肌筋膜炎的乌青姜发热凝胶膏剂及其制备方法 | |
CN108030862A (zh) | 一种口腔用中药膜剂及其制备方法 | |
CN108653377A (zh) | 一种治疗皮肤创伤的蒙药贴剂及制备方法 | |
CN103285035B (zh) | 一种治疗干性皮肤冻疮的药物及其制作方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CB02 | Change of applicant information |
Address after: 465550 No. 666 General Road, Xinxian County, Xinyang City, Henan Province Applicant after: Henan Lingrui Pharmaceutical Co., Ltd. Address before: 465550 No. 232 Xiangyang Road, Xinxian County, Xinyang City, Henan Province Applicant before: Henan Lingrui Pharmaceutical Co., Ltd. |
|
CB02 | Change of applicant information | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180821 |
|
RJ01 | Rejection of invention patent application after publication |