CN108420905B - 一种防治口腔炎和咽炎油茶及其制备方法 - Google Patents
一种防治口腔炎和咽炎油茶及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种防治口腔炎和咽炎油茶,按重量份计,其组方的原料包括:油茶果壳20~50份,山鸡椒10~30份,鹅掌草5~20份,马兰花5~20份,曼珠沙华5~20份,紫藤萝5~15份。本发明还公开了上述油茶的制备方法,油茶组方加水室温浸泡,再通入水蒸气蒸馏,油水分离,得挥发油组份;蒸馏后的残液经过滤分离,收集滤液,加入大孔树脂吸附,再用30~70%乙醇解吸,解吸液回收乙醇后,喷雾干燥,得水提组份;将挥发油组份与水提组份混合均匀,即得油茶组方提取物。本发明的油茶具有抗炎功效,可用作防治口腔炎和咽炎的制剂。
Description
技术领域
本发明涉及防治口腔炎和咽炎的医药领域,特别涉及防治口腔炎和咽炎油茶组方及其制备方法与应用。
背景技术
口腔、咽喉炎症主要指急慢性咽喉炎、急性扁桃体炎、口腔溃疡、口腔炎、牙齿肿痛、口源性口臭等。由于机体免疫力低下,导致口腔咽喉的致病微生物感染,同时也有机械损伤或用嗓过度所致。此病可多次、反复发生,但因临床症状较轻,就诊率较低,具有确切预防和治疗作用的相关产品不多,如双料喉风散、西瓜霜、金嗓子喉片等,但它们都侧重于喉部疾病。因此,开发一种使用安全、便捷,适于长期使用的用于预防或治疗口腔、咽喉常见病症,清除口腔异味,缓解咽部不适的天然药物,具有重要的意义和价值。
发明内容
为了克服现有技术的上述缺点与不足,本发明的目的之一在于提供一种防治口腔炎和咽炎油茶组方,具有驱风清热、解毒降火、消肿止痛功效。
本发明的另一目的在于提供上述防治口腔炎和咽炎油茶组方的制备方法。
本发明的目的通过以下技术方案实现:
一种防治口腔炎和咽炎油茶,按重量份计,其组方的原料包括:
油茶果壳20~50份,山鸡椒10~30份,鹅掌草5~20份,马兰花5~20份,曼珠沙华5~20份,紫藤萝5~15份。
所述的防治口腔炎和咽炎油茶的制备方法,包括以下步骤:
(1)按组方称量原料,加水室温浸泡,再通入水蒸气蒸馏,油水分离,得挥发油组份;
(2)蒸馏后的残液经过滤分离,收集滤液,加入大孔树脂吸附,再用30~70%体积浓度的乙醇水解吸,解吸液回收乙醇后,喷雾干燥,得水提组份;
(3)将挥发油组份与水提组份混合均匀,即得防治口腔炎和咽炎油茶。
所述加水,具体为:加入原料总重量6~20倍的水。
所述浸泡,具体为:浸泡1~3h。
所述水蒸气蒸馏,具体为:水蒸气蒸馏2~5h。
所述大孔树脂为弱极性或非极性大孔树脂,
所述大孔树脂用量为原料总重量的1~10倍。
所述大孔树脂为AB-8、DM130、HP100、D101中的一种。
所述解吸液用量为大孔树脂用量的2~5倍。
本发明的原理:本组方按照中医理论组方,中医认为口腔和咽炎为外感风热、脾胃积热、虚火上浮所致,宜驱风清热、解毒降火、消肿止痛。油茶果壳因具有抗菌和收敛凉血,止血的功效,本方中为君药;山鸡椒具有祛风、消肿止痛作用,本方中为臣药;其它具镇痛、解毒功效的鹅掌草、马兰花、曼珠沙华为佐药;紫藤萝则为使药。其组方活性成分通过水蒸汽蒸馏和大孔树脂富聚后,具有更好的疗效。以下为各方的来源和功效:
油茶果壳:油茶树为山茶科山茶属灌木或中乔木,其果壳中主要活性成分为鞣质和糖醛,具有抗菌消炎、清热解毒、收敛止血和止痛功效。
山鸡椒:系樟科木姜子属多年生落叶小乔木,又名木香子、木姜子、山苍子等,叶中主要活性成分为柠檬醛,具祛风、消肿止痛的功效。
鹅掌草,毛茛科银莲花属多年生草本,叶片多为3-5片,粉红色花瓣,4-6月开花。具有抗炎抗菌,镇痛,消肿功效。
马兰花,鸢尾科鸢尾属多年生草本植物,花瓣颜色多呈蓝紫色,具有清热解毒、消肿散瘀止痛功效。
曼珠沙华,石蒜类植物,有很好的消炎败火的作用。由于它能消肿、杀虫、治疔疮疖肿、风湿关节痛、水肿、防瘟疫等,所以又被称健康的守护神。
紫藤萝,豆科植物,花多成片生长,景象奇特,可食用,能够利水消肿解毒、止吐泻、驱虫。
与现有技术相比,本发明具有以下优点和有益效果:
(1)本发明的防治口腔炎和咽炎油茶组方,具有驱风清热、解毒降火、消肿止痛的功效。
(2)本发明先用水蒸汽蒸馏得到组方的挥发油组份,再以大孔树脂吸附得到水提液中的活性组份,因此充分获得了组方中的精华,提高了药物疗效。
(3)本发明制备工艺简单,便于工业化生产。
具体实施方式
下面结合实施例,对本发明作进一步地详细说明,但本发明的实施方式不限于此。
实施例
实施例1
组方:油茶果壳40,山鸡椒30,鹅掌草10,马兰花5,曼珠沙华10,紫藤萝5。
制备方法:
将组方100g,加1kg水室温浸泡2h,再通入水蒸气蒸馏2h,油水分离,得挥发油组份2.3g;蒸馏后的残液经过滤分离,收集滤液,加入0.5kg AB-8、大孔树脂吸附10h,再用1.5kg50%乙醇解吸,解吸液回收乙醇后,喷雾干燥,得水提组份24g;将挥发油组份与水提组份混合均匀,即得油茶组方提取物。
实施例2
组方:油茶果壳50,山鸡椒20,鹅掌草5,马兰花10,曼珠沙华5,紫藤萝10。
制备方法:
将组方100g,加2kg水室温浸泡1h,再通入水蒸气蒸馏5h,油水分离,得挥发油组份3.1g;蒸馏后的残液经过滤分离,收集滤液,加入1kg DM130大孔树脂吸附12h,再用2kg70%乙醇解吸,解吸液回收乙醇后,喷雾干燥,得水提组份29g;将挥发油组份与水提组份混合均匀,即得油茶组方提取物。
实施例3
组方:油茶果壳20,山鸡椒20,鹅掌草20,马兰花15,曼珠沙华15,紫藤萝10。
制备方法:
将组方100g,加0.6kg水室温浸泡3h,再通入水蒸气蒸馏3h,油水分离,得挥发油组份2.5g;蒸馏后的残液经过滤分离,收集滤液,加入组方重量的0.1kg HP100大孔树脂吸附6h,再用0.2kg 60%乙醇解吸,解吸液回收乙醇后,喷雾干燥,得水提组份16g;将挥发油组份与水提组份混合均匀,即得油茶组方提取物。
实施例4
组方:油茶果壳30,山鸡椒25,鹅掌草15,马兰花10,曼珠沙华5,紫藤萝15。
制备方法:
将组方100g,加1.2kg水室温浸泡1.5h,再通入水蒸气蒸馏2.5h,油水分离,得挥发油组份2.7g;蒸馏后的残液经过滤分离,收集滤液,加入0.3kgD101大孔树脂吸附8h,再用0.9kg 40%乙醇解吸,解吸液回收乙醇后,喷雾干燥,得水提组份19g;将挥发油组份与水提组份混合均匀,即得油茶组方提取物。
实施例5
组方:油茶果壳35,山鸡椒15,鹅掌草5,马兰花20,曼珠沙华20,紫藤萝5。
制备方法:
将组方100g,加1.6kg水室温浸泡2.5h,再通入水蒸气蒸馏3h,油水分离,得挥发油组份3.4g;蒸馏后的残液经过滤分离,收集滤液,加入0.8kg AB-8大孔树脂吸附7h,再用1.6kg 55%乙醇解吸,解吸液回收乙醇后,喷雾干燥,得水提组份27g;将挥发油组份与水提组份混合均匀,即得油茶组方提取物。
实施例6
组方:油茶果壳45,山鸡椒10,鹅掌草10,马兰花15,曼珠沙华10,紫藤萝10。
制备方法:
将组方100g,加1.8kg水室温浸泡1h,再通入水蒸气蒸馏4.5h,油水分离,得挥发油组份2.5g;蒸馏后的残液经过滤分离,收集滤液,加入0.9kg DM130大孔树脂吸附11h,再用3.6kg 45%乙醇解吸,解吸液回收乙醇后,喷雾干燥,得水提组份23g;将挥发油组份与水提组份混合均匀,即得油茶组方提取物。
实施例7
将适量蔗糖粉、糊精与油茶组方提取物,三者重量比为6:2:1,放入槽形混合机内混合,加入适量75%乙醇制成软材,放到摇摆式制粒机内制成湿颗粒。40~45℃干燥,整粒后加入0.5wt%硬脂酸镁混匀,压片即得油茶组方消炎利咽含片。
实施例8
将油茶组方提取物15重量份,赤藓糖醇6重量份,口香糖胶基30重量份(预先进行50~60℃软化处理),充分搅拌混匀;放入挤出机内挤出成型,即得一种抑菌、清新口气的油茶组方无糖口香糖。
实施例9
将油茶组方提取物5重量份、十二烷基硫酸钠1重量份混合溶于适量双蒸水,然后缓缓加入75%乙醇3重量份、山梨糖醇1.5重量份、丙三醇1重量份,拌匀,过滤,添加双蒸水至100重量份,即得一种消炎消肿、清新口气漱口水。
测试 油茶组方提取物的效果评价
(1)油茶组方提取物的抗炎性实验
方法:取雄性小鼠90只,随机分为9组,每组10只。第1组给生理盐水,灌胃,为阴性对照组;第2组给阿司匹林200mg/kg,灌胃,为阳性对照组;第3~4组分别实施例1油茶组方提取物低剂量(50mg/kg)和高剂量组(200mg/kg),第5~9组分别为实施例2~6油茶组方提取物组(200mg/kg),灌胃。每天1次,3天后,于末次给药1h后,在每只动物右耳前后两面涂二甲苯0.02ml致炎。各组致炎1h后,将动物颈椎脱臼致死,沿耳廓基线剪下两耳,用7mm直径打孔器分别在同一部位打下圆耳片,称重。肿胀度和肿胀抑制率(%)计算公式:
肿胀度=右耳片重量-左耳片的重量
肿胀抑制率(%)=(对照组平均肿胀度-给药组平均肿胀度)/对照组平均肿胀度×100
结果:致炎1h后,各组小鼠右耳均可见明显红肿。阳性对照组和油茶组方提取物各组对二甲苯致小鼠耳肿胀均有明显的抑制作用(P<0.05),高剂量组与阳性对照组比较,差异显著(P<0.05)。说明油茶组方提取物的抗炎作用优于阳性对照。结果见附表1。
(2)油茶组方提取物的热板法镇痛实验
方法:将小鼠置于(55±0.5)℃热板上,观察和记录小鼠开始放在热板上至添后足的时间作为痛反应潜伏期,选取痛反应潜伏期为10~25s范围内的雌性小鼠90只,随机分为9组,每组10只。第1组给生理盐水,灌胃,为阴性对照组;第2组给阿司匹林200mg/kg,灌胃,为阳性对照组;第3~4组分别为实施例1油茶组方提取物低剂量(50mg/kg)和高剂量组(200mg/kg),第5~9组分别为实施例2~6油茶组方提取物组(200mg/kg),灌胃。分别于给药后1,1.5,2h测定痛阈值。如小鼠在热板上停留60s后仍无痛反应,应立即取出,按60s计算。镇痛百分率(%)计算公式:
镇痛百分率(%)=(用药后平均痛阈值-用药前平均痛阈值)/用药前平均痛阈值×100
结果:与阴性对照组相比,阳性对照组和油茶组方提取物在给药后不同时间点出现的舔足的潜伏期均明显延长(P<0.05),高剂量组与阳性对照的抑制作用比较,差异显著(P<0.05)。提示油茶组方提取物具有良好的镇痛作用,效果优于阳性对照。结果见附表2。
附表2油茶组方提取物对热板所致小鼠痛阈的抑制实验
上述实施例为本发明较佳的实施方式,但本发明的实施方式并不受所述实施例的限制,其他的任何未背离本发明的精神实质与原理下所作的改变、修饰、替代、组合、简化,均应为等效的置换方式,都包含在本发明的保护范围之内。
Claims (8)
1.一种防治口腔炎和咽炎油茶,其特征在于,按重量份计,由以下组方的原料组成: 油茶果壳20~50份,山鸡椒10~30份,鹅掌草5~20份,马兰花5~20份,曼珠沙华5~20份,紫藤萝5~15份;
所述油茶由包括以下步骤方法制备得到:
(1)按组方称量原料,加水室温浸泡,再通入水蒸气蒸馏,油水分离,得挥发油组份;
(2)蒸馏后的残液经过滤分离,收集滤液,加入大孔树脂吸附,再用30~70%体积浓度的乙醇水解吸,解吸液回收乙醇后,喷雾干燥,得水提组份;
(3)将挥发油组份与水提组份混合均匀,即得防治口腔炎和咽炎油茶。
2.根据权利要求1所述的防治口腔炎和咽炎油茶,其特征在于,所述加水,具体为:加入原料总重量6~20倍的水。
3.根据权利要求1所述的防治口腔炎和咽炎油茶,其特征在于,所述浸泡,具体为:浸泡1~3h。
4.根据权利要求1所述的防治口腔炎和咽炎油茶,其特征在于,所述水蒸气蒸馏,具体为:水蒸气蒸馏2~5h。
5.根据权利要求1所述的防治口腔炎和咽炎油茶,其特征在于,所述大孔树脂为弱极性或非极性大孔树脂。
6.根据权利要求1所述的防治口腔炎和咽炎油茶,其特征在于,所述大孔树脂用量为原料总重量的1~10倍。
7.根据权利要求1所述的防治口腔炎和咽炎油茶,其特征在于,所述大孔树脂为AB-8、DM130、HP100、D101中的一种。
8.根据权利要求1或5所述的防治口腔炎和咽炎油茶,其特征在于,所述解吸液用量为大孔树脂用量的2~5倍。
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