CN108420761A - A kind of horseradish ferment toothpaste and preparation method thereof - Google Patents
A kind of horseradish ferment toothpaste and preparation method thereof Download PDFInfo
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- CN108420761A CN108420761A CN201810372782.XA CN201810372782A CN108420761A CN 108420761 A CN108420761 A CN 108420761A CN 201810372782 A CN201810372782 A CN 201810372782A CN 108420761 A CN108420761 A CN 108420761A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The present invention provides a kind of horseradish ferment toothpaste and preparation method thereof, horseradish ferment toothpaste component of the present invention is simple, mainly use moisturizer, thickener, foaming agent, additive, serrapeptass, alpha amylase, pancreatic lipase, horseradish powder and the flavoring agent of specific consumption proportion, in particular by the serrapeptass, alpha amylase, pancreatic lipase of specific consumption proportion, cleaning effect can be fully improved；And the use of horseradish powder, it can further promote serrapeptass, alpha amylase and pancreatic lipase that can give full play to effect, fully improve cleaning effect；Serrapeptass, alpha amylase, pancreatic lipase and horseradish powder, which can also coordinate, simultaneously plays the role of antibacterial bacteriostatic.The preparation method of horseradish ferment toothpaste of the present invention is simple for process, is suitable for large-scale production.
Description
Technical field
The present invention relates to technical field of daily necessities, in particular to a kind of horseradish ferment toothpaste and preparation method thereof.
Background technology
Toothpaste is the common life cleaning supplies in people's daily life, with the development of science and technology, having researched and developed simultaneously at present
All kinds of toothpaste have been produced, have been selected for the crowd of different demands.
Ferment, that is, enzyme are the special organic matter (eggs with catalytic activity and high selectivity generated by living cells
White matter, RNA, DNA), wherein most enzymes are protein.Different ferment is respectively provided with specific catalysis.
In the related technology, it has attempted to apply ferment with the production of toothpaste, but produce little effect, still lean on the whole big
Amount uses rubbing agent, completes the cleaning to oral cavity.Simultaneously as daily brushing time is limited, and oral environment may not also fit
It closes the ferment added in toothpaste and plays effect, synthesis cleaning effect is still limited, compared with the tooth paste product without using ferment
It is limited to promote effect.
In view of this, special propose the present invention.
Invention content
The first object of the present invention is to provide a kind of horseradish ferment toothpaste, and the horseradish ferment toothpaste component is simple,
It is excellent to the cleaning effect in oral cavity, antibacterial bacteriostatic can be played the role of, the use of horseradish gives full play to effect tool for ferment
There is significant synergistic effect.
The second object of the present invention is to provide a kind of preparation method of the horseradish ferment toothpaste, this method technique letter
It is single, it is suitable for large-scale production.
In order to realize that the above-mentioned purpose of the present invention, spy use following technical scheme：
A kind of horseradish ferment toothpaste, the horseradish ferment toothpaste are mainly prepared by the ingredient of following mass fraction meter：
30-40 parts of moisturizer, 2-8 parts of thickener, 0.1-2 parts of foaming agent, 10-15 parts of additive, serrapeptass 0.5-3
Part, 0.1-0.5 parts of alpha-amylase, 0.1-1 parts of pancreatic lipase, 0.1-0.5 parts of horseradish powder and 0.1-2 parts of flavoring agent.
Horseradish ferment toothpaste component of the present invention is simple, mainly using the moisturizer of specific consumption proportion, thickener, foaming
Agent, additive, serrapeptass, alpha-amylase, pancreatic lipase, horseradish powder and flavoring agent, in particular by specific consumption proportion
Serrapeptass, alpha-amylase, pancreatic lipase can fully improve cleaning effect；And the use of horseradish powder, can further it promote
Serrapeptass, alpha-amylase and pancreatic lipase can give full play to effect, fully improve cleaning effect；Serrapeptass, α-simultaneously
Amylase, pancreatic lipase and horseradish powder, which can also coordinate, plays the role of antibacterial bacteriostatic.
Preferably, the horseradish ferment toothpaste is mainly prepared by the ingredient of following mass fraction meter：
32-38 parts of moisturizer, 4-6 parts of thickener, 0.5-1.5 parts of foaming agent, 11-14 parts of additive, serrapeptass 1-2
Part, 0.2-0.4 parts of alpha-amylase, 0.3-0.7 parts of pancreatic lipase, 0.2-0.4 parts of horseradish powder and 0.5-1.5 parts of flavoring agent.
It is further preferred that the horseradish ferment toothpaste is mainly prepared by the ingredient of following mass fraction meter：
35 parts of moisturizer, 5 parts of thickener, 1 part of foaming agent, 12 parts of additive, 1.5 parts of serrapeptass, alpha-amylase 0.3
Part, 0.5 part of pancreatic lipase, 0.3 part of horseradish powder and 1 part of flavoring agent.
Optionally, the raw material for preparing of the horseradish powder ferment toothpaste further includes water.
Optionally, the dosage of the water is the moisturizer, thickener, additive, serrapeptass, alpha-amylase, pancreas fat
The 10%-30% of fat enzyme, horseradish powder and flavoring agent gross mass, preferably 15%-25%, further preferably 20%.
Optionally, the moisturizer includes one or more in alcohols moisturizer, preferably includes glycerine and/or sorb
Alcohol.
Optionally, the thickener includes one or more in cellulose thickener, preferably includes carboxymethyl cellulose
Element and/or hydroxyethyl cellulose.
Optionally, the additive includes one or more in rubbing agent, preferably includes silica.
Optionally, the flavoring agent preferably includes one or more in aromatic and sweetener.
Optionally, the aromatic includes one or more in Thymol, eugenol and peppermint oil.
Optionally, the sweetener includes saccharin sodium, aspartame, stevioside and one kind or more in tri-chloro galactose type sugar
Kind.
Optionally, the foaming agent includes lauryl sodium sulfate and/or dodecanoyl sodium sarcosinate.
A kind of preparation method of above-mentioned horseradish ferment toothpaste, including：
In proportion by moisturizer, thickener, additive, serrapeptass, alpha-amylase, pancreatic lipase, horseradish powder and seasoning
Agent is thoroughly mixed uniformly, obtains a kind of horseradish powder ferment toothpaste.
The preparation method of horseradish ferment toothpaste of the present invention is simple for process, is suitable for large-scale production.
Optionally, the preparation method of a kind of horseradish ferment toothpaste, including：
In proportion by moisturizer, thickener, additive, serrapeptass, alpha-amylase, pancreatic lipase, horseradish powder, flavoring agent
It is thoroughly mixed uniformly with water, obtains a kind of horseradish powder ferment toothpaste.
Optionally, the preparation method of the horseradish powder includes：
It is crushed after horseradish root is freezed, obtains horseradish powder.
Optionally, the horseradish root is crushed to grain size as 10 μm hereinafter, preferably 1 μm or less.
Compared with prior art, beneficial effects of the present invention are：
Horseradish ferment toothpaste component of the present invention is simple, mainly using the moisturizer of specific consumption proportion, thickener, foaming
Agent, additive, serrapeptass, alpha-amylase, pancreatic lipase, horseradish powder and flavoring agent, in particular by specific consumption proportion
Serrapeptass, alpha-amylase, pancreatic lipase can fully improve cleaning effect；And the use of horseradish powder, can further it promote
Serrapeptass, alpha-amylase and pancreatic lipase can give full play to effect, fully improve cleaning effect；Serrapeptass, α-simultaneously
Amylase, pancreatic lipase and horseradish powder, which can also coordinate, plays the role of antibacterial bacteriostatic.The preparation side of horseradish ferment toothpaste of the present invention
Method is simple for process, is suitable for large-scale production.
Specific implementation mode
Technical scheme of the present invention is clearly and completely described below in conjunction with specific implementation mode, but ability
Field technique personnel will be understood that following described embodiments are some of the embodiments of the present invention, instead of all the embodiments,
It is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.Based on the embodiments of the present invention, the common skill in this field
The every other embodiment that art personnel are obtained without making creative work belongs to the model that the present invention protects
It encloses.The person that is not specified actual conditions in embodiment, carries out according to conventional conditions or manufacturer's recommended conditions.Agents useful for same or instrument
Production firm person is not specified, is the conventional products that can be obtained by commercially available purchase.
The specific embodiment of the invention provides a kind of horseradish ferment toothpaste, and the horseradish ferment toothpaste is mainly by following matter
The ingredient of amount number meter is prepared：
30-40 parts of moisturizer, 2-8 parts of thickener, 0.1-2 parts of foaming agent, 10-15 parts of additive, serrapeptass 0.5-3
Part, 0.1-0.5 parts of alpha-amylase, 0.1-1 parts of pancreatic lipase, 0.1-0.5 parts of horseradish powder and 0.1-2 parts of flavoring agent.
Horseradish：Chinese scientific name Eutrema yunnanense, Classification system Eutrema yunnanense, Papaverales, Cauliflower suborder, cross
Hua Ke, Sisymbrieae, green onion mustard subtribe, Eutrema, southern Eutrema yunnanense group, are that one kind being grown on 1300-2500 meters of high and cold mountains of height above sea level
Rare pungent fragrant plants and vegetables under area's woods the moon.Horseradish is a kind of special edible health plant found in the world today,
It is extremely precious seasoned food on international market, it is expensive, the market demand is very big.Since horseradish growth conditions is special, suitable
The place for preferably growing plantation is limited, and horseradish product now in the international market is extremely rare.Horseradish is not only in good taste, has abundant
Nutritional ingredient also contains immunoregulation effect and the multiple pharmacological effects such as antibacterial, anticancer, anti-oxidant.
Horseradish ferment toothpaste component of the present invention is simple, mainly using the moisturizer of specific consumption proportion, thickener, foaming
Agent, additive, serrapeptass, alpha-amylase, pancreatic lipase, horseradish powder and flavoring agent, in particular by specific consumption proportion
Serrapeptass, alpha-amylase, pancreatic lipase can fully improve cleaning effect；And the use of horseradish powder, can further it promote
Serrapeptass, alpha-amylase and pancreatic lipase can give full play to effect, fully improve cleaning effect；Serrapeptass, α-simultaneously
Amylase, pancreatic lipase and horseradish powder, which can also coordinate, plays the role of antibacterial bacteriostatic.
The present invention can not use shape of the conventional dentifrices using a large amount of rubbing agents (calcium carbonate, calcium monohydrogen phosphate, calcium pyrophosphate etc.)
Formula can not use fluorochemical, can not also use antibacterials, by special formulation, give full play to serrapeptass, alphalise starch
Tooth is effectively cleaned in the effect of enzyme and pancreatic lipase, reduces physical friction of the conventional friction agent to tooth, protects gum, and
Ferment itself can play the role of antibacterial anti-inflammatory.
Serrapeptass is to belong to a kind of restriction endonuclease obtained by the fermented extraction of bacillus subtilis, can be used for each hatching egg
Macro-molecular protein can be hydrolyzed to the products such as amino acid by white matter hydrolysis process.It can be widely applied to the hydrolysis of animal/vegetable protein.
The present invention utilizes this principle, removes remaining protein matter on oral cavity and tooth.
Alpha-amylase can hydrolyze α-Isosorbide-5-Nitrae-glycosidic bond inside starch, and hydrolysate is dextrin, oligosaccharide and monosaccharide, enzyme
The viscosity of gelatinized starch can be made to reduce rapidly after effect, become liquefying starch.The addition of this ingredient, which can remove, remains in oral cavity
With the starchy material on tooth, the generation of dental calculus is prevented.
Pancreatic lipase is the most important enzyme for hydrolyzing dietary fat, is a kind of enzyme with a variety of catalytic capabilities, has efficiently
The effect of hydrolyzed fat.Pancreatic lipase removes the fats residuals in oral cavity, reaches cleaning oral cavity, the effect of tooth.
Using the serrapeptass of specific usage ratio, alpha-amylase and pancreatic lipase, help to further increase gained mountain
The cleaning of certain herbaceous plants with big flowers ferment toothpaste and antibiotic effect.
Preferably, the horseradish ferment toothpaste is mainly prepared by the ingredient of following mass fraction meter：
32-38 parts of moisturizer, 4-6 parts of thickener, 0.5-1.5 parts of foaming agent, 11-14 parts of additive, serrapeptass 1-2
Part, 0.2-0.4 parts of alpha-amylase, 0.3-0.7 parts of pancreatic lipase, 0.2-0.4 parts of horseradish powder and 0.5-1.5 parts of flavoring agent.
It is further preferred that the horseradish ferment toothpaste is mainly prepared by the ingredient of following mass fraction meter：
35 parts of moisturizer, 5 parts of thickener, 1 part of foaming agent, 12 parts of additive, 1.5 parts of serrapeptass, alpha-amylase 0.3
Part, 0.5 part of pancreatic lipase, 0.3 part of horseradish powder and 1 part of flavoring agent.
Using the moisturizer of specific consumption proportion, thickener, additive, serrapeptass, alpha-amylase, pancreatic lipase, mountain
Certain herbaceous plants with big flowers powder and flavoring agent contribute to the cleaning and the antibiotic effect that further increase gained horseradish ferment toothpaste.
In a kind of optional specific implementation mode of the present invention, the raw material for preparing of the horseradish powder ferment toothpaste further includes water.
In a kind of optional specific implementation mode of the present invention, the dosage of the water is the moisturizer, thickener, addition
Agent, serrapeptass, alpha-amylase, pancreatic lipase, horseradish powder and flavoring agent gross mass 10%-30%, preferably 15%-
25%, further preferably 20%.
Using the water of specific dosage, contribute to the full and uniform mixing of each raw material, improves stability.
Moisturizer is that have the mobility for keeping lotion moisture, safeguarding lotion in toothpaste, reduce freezing point, processing easy to produce
The material composition used with consumer.Main function is：(1) moisture for keeping lotion can be prevented when toothpaste exposes in air
The evaporation of sealing point, makes the toothpaste at nozzle be not easy dry and hard, is readily extruded；(2) rheological characteristic for keeping lotion, adds convenient for machinery
Work；(3) freezing point of toothpaste is reduced；(4) water in lotion will not be led to when melting again after toothpaste frost by improving the azeotropic point of toothpaste
Separation, even if lotion is still stablized under high temperature (general 50 DEG C).Moisturizer should generally have following condition：(1) have good
Moisture absorption and performance of keeping humidity.(2) coordinate with water, there is good anti-freezing property.(3) safe and nontoxic, harmless, meet food
Grade or pharmaceutical grade requirement.(4) without bad mouthfeel.(5) good with toothpaste other compositions compatibility.
In a kind of optional specific implementation mode of the present invention, the moisturizer includes one kind or more in alcohols moisturizer
Kind, preferably include glycerine and/or sorbierite.
Thickener is dispersion, swells in toothpaste liquid phase, forms stable colloid, with the toothpaste solid phase that suspends, is prevented solid in toothpaste
The material composition that phase component is detached with liquid phase component.Its main function is：(1) make toothpaste that there is viscosity appropriate and consistency, again
Do not feel sticky, there is good mobile performance.(2) make toothpaste that there is skeleton, the toothpaste of extrusion can rest on toothbrush and will not collapse
Under, there is good stripping energy.(3) when brushing teeth, toothpaste is easy dispersion, there is good diffusion.(4) self stability is good,
It is not susceptible to biodegradation, lotion is stablized not stratified during storage, does not isolate water, does not influence the smell and color and luster of toothpaste, has
Good stability.(5) so that lotion exquisite luster, abrasive material is uniformly dispersed, do not tie viscous return slightly.(6) with toothpaste in other components,
The compatibility of especially active material is good, there is good compatibility.Thickener is powdery colloidality substance mostly, in toothpaste
Requirement is：(1) there are good viscosity and thixotropy.(2) it is easy dispersion and swelling when cream processed produces, does not generate knot burl
Block phenomenon.(3) good water solubility is easy to combine other each materials in toothpaste.(4) there is preferable antienzyme ability and salt tolerant energy
Power not will produce the degradation for destroying toothpaste stability within the toothpaste shelf-life.(5) preferable hair property thoroughly can be brought to essence.No
Uncomfortable aroma and flavor can be brought into toothpaste.(6) color and luster of toothpaste cannot be influenced.
In a kind of optional specific implementation mode of the present invention, the thickener include one kind in cellulose thickener or
It is a variety of, preferably include carboxymethyl cellulose and/or hydroxyethyl cellulose.
Abrasive is can to wipe dental surface tartar with toothbrush collective effect in toothpaste, mitigates tooth stain, plaque, tooth
The solid material ingredient of the foreign substances such as calculus.Toothpaste abrasive particle diameter should be between 5-40 μm, and grain size is excessive, brushes teeth
When have apparent feeling of grittiness；Lotion of toothpaste made of the suitable abrasive of granularity, counterpart when having the appearance of smooth exquisiteness and brushing teeth
The comfort sense of chamber, gum；Granularity is meticulous (such as less than 1 μm), and toothpaste holder will appear when trying returns thick phenomenon, this is because toothpaste is in length
In the examination of phase storage rack, meticulous abrasive is caused by flocculation occurs for the relationship of Brownian movement.
In a kind of optional specific implementation mode of the present invention, the additive include it is one or more in rubbing agent, it is excellent
Choosing includes silica.
The characteristics of Silica Using for Toothpaste is that have good thixotropy and abrasion resistance.Because its good thixotropy can have
The toothpaste for solving the problems, such as to brush teeth of effect is scaling-off, simultaneously as its abrasion resistance coefficient is matched with tooth, reduces the abrasion to tooth
Degree, and chemical property is stable, safety.In the production of existing toothpaste industry, most of calcium dihydrogen phosphate, lightweight carbonic acid
Calcium, aluminium oxide etc. are used as filler, these substances to exist herein as just filler mostly, and as a result of a large amount of
Phosphide, easily cause water quality richness phosphorus, cause secondary environmental pollution, furthermore, the wearing coefficients of these substances and tooth it is resistance to
It is too big to grind coefficient difference, damage can be generated to tooth by being excessively used.And wear-resisting system of the Silica Using for Toothpaste according to human teeth
Number is selected to be modulated；And easy to knot groups when solving toothpaste use, it is scaling-off the problems such as, tests prove that, have and tooth phase
Matched wearing coefficient reduces the abrasion to tooth, increases the whiteness of tooth；And use Silica Using for Toothpaste
Toothpaste is carved quickly form pulpous state when in use, is not easy scaling-off, and the toothpaste dosage brushed teeth every time is made to greatly reduce.
The toothpaste fragrance that flavoring agent is with reference to natural plants, is allocated using natural perfume material and synthetic perfume, is had
The material composition of natural flavour mountaineous and various odor types.Toothpaste flavoring agent will not only assign the fragrance of the certain type of toothpaste, Er Qieyao
The taste for assigning certain type, making consumer, oral cavity feels pleasure comfortable, while refrigerant frankness when in use.It is certain in toothpaste
Ingredient (such as the present invention use horseradish) has a special aroma and flavor, toothpaste essence can these hidden peculiar smell, allow and disappear
The person of expense giocoso receives and uses.
In a kind of optional specific implementation mode of the present invention, the flavoring agent preferably includes one in aromatic and sweetener
Kind is a variety of.
In a kind of optional specific implementation mode of the present invention, the aromatic includes Thymol, eugenol and peppermint oil
In it is one or more.
Thymol, eugenol and peppermint oil are also capable of providing bacteriostasis efficacy, while right while playing the role of fragrance
The mouth diseases such as periodontosis, halitosis have certain auxiliary curative effect.
In a kind of optional specific implementation mode of the present invention, the sweetener include saccharin sodium, aspartame, stevioside and
It is one or more in tri-chloro galactose type sugar.
To avoid toothpaste fermentation souring, sugar cannot be used in formulation of tooth-paste.The sugariness of sweetener is similar to sucrose, calorific value
It is relatively low, there are different metabolic processes from glucose, there is certain use value.Sorbierite, glycerine for being used in toothpaste etc.
Certain sweet taste can be provided.Saccharin sodium, aspartame (Aspartame), stevioside, tri-chloro galactose type sugared (Sucralose) can carry
For higher sugariness.
Foaming agent (also known as surfactant) is can to reduce surface tension of liquid in toothpaste, have good wetting, hair
Bubble emulsifies, the material composition of detergent action.The emulsification of foaming agent contributes to its in the oil soluble materials such as essence and lotion
He is uniformly combined into stable system at component.The abundant foam generated when brushing teeth, can suspend tartar etc., be flush with water when gargling
It removes, to achieve the purpose that remove tartar, cleaning oral cavity.Toothpaste foaming agent, it is necessary to stingless to gum and oral mucosa
Swash property, safe and non-toxic, no bad smell does not interfere subject to toothpaste fragrance.
In a kind of optional specific implementation mode of the present invention, the foaming agent includes lauryl sodium sulfate and/or 12
Sarcosinate.
Other functional components such as food coloring can also be added in horseradish ferment toothpaste of the present invention.
A kind of preparation method of above-mentioned horseradish ferment toothpaste, including：
In proportion by moisturizer, thickener, additive, serrapeptass, alpha-amylase, pancreatic lipase, horseradish powder and seasoning
Agent is thoroughly mixed uniformly, obtains a kind of horseradish powder ferment toothpaste.
The preparation method of horseradish ferment toothpaste of the present invention is simple for process, is suitable for large-scale production.
In a kind of optional specific implementation mode of the present invention, a kind of preparation method of horseradish ferment toothpaste, including：
In proportion by moisturizer, thickener, additive, serrapeptass, alpha-amylase, pancreatic lipase, horseradish powder, flavoring agent
It is thoroughly mixed uniformly with water, obtains a kind of horseradish powder ferment toothpaste.
In a kind of optional specific implementation mode of the present invention, the preparation method of the horseradish powder includes：
It is crushed after horseradish root is freezed, obtains horseradish powder.
In a kind of optional specific implementation mode of the present invention, the horseradish root be crushed to grain size be 10 μm hereinafter, it is preferred that
It is 1 μm or less.
Using the horseradish powder of specified particle diameter, contribute to the cleaning and the antibacterial work(that further increase gained horseradish ferment toothpaste
Effect.
Optionally, the cryogenic temperature is -10 to -20 DEG C.
Optionally, the cooling time is 12-24h.
Embodiment 1
A kind of preparation method of horseradish ferment toothpaste, including：
A. take horseradish root, freezed for 24 hours at -10 DEG C after cleaning, after through pulverizing and sieving, collection cut size be 10 μm or less
Horseradish powder；
B. 30 parts of glycerine, 2 parts of carboxymethyl cellulose, 0.1 part of lauryl sodium sulfate, Silica Using for Toothpaste are weighed respectively
0.1 part of 10 parts, 0.5 part of serrapeptass, 0.1 part of alpha-amylase, 0.1 part of pancreatic lipase, 0.1 part of horseradish powder and eugenol；
C. above-mentioned raw materials are thoroughly mixed in water uniformly, the dosage of the water is above-mentioned raw materials gross mass
10%, obtain a kind of horseradish ferment toothpaste.
Embodiment 2
A kind of preparation method of horseradish ferment toothpaste, including：
A. take horseradish root, freeze 12h after cleaning at -20 DEG C, after through pulverizing and sieving, collection cut size be 8 μm or less
Horseradish powder；
B. 40 parts of sorbierite, 8 parts of hydroxyethyl cellulose, 2 parts of dodecanoyl sodium sarcosinate, toothpaste titanium dioxide are weighed respectively
2 parts of 15 parts of silicon, 3 parts of serrapeptass, 0.5 part of alpha-amylase, 1 part of pancreatic lipase, 0.5 part of horseradish powder and stevioside；
C. above-mentioned raw materials are thoroughly mixed in water uniformly, the dosage of the water is above-mentioned raw materials gross mass
30%, obtain a kind of horseradish ferment toothpaste.
Embodiment 3
A kind of preparation method of horseradish ferment toothpaste, including：
A. take horseradish root, freeze 20h after cleaning at -12 DEG C, after through pulverizing and sieving, collection cut size be 5 μm or less
Horseradish powder；
B. 20 parts of glycerine, 12 parts of sorbierite, 2 parts of carboxymethyl cellulose, 2 parts of hydroxyethyl cellulose, dodecane are weighed respectively
0.2 part of base sodium sulphate, 0.3 part of dodecanoyl sodium sarcosinate, 11 parts of Silica Using for Toothpaste, 1 part of serrapeptass, alpha-amylase
0.3 part of 0.2 part, 0.3 part of pancreatic lipase, 0.2 part of horseradish powder, 0.2 part of Thymol and aspartame；
C. above-mentioned raw materials are thoroughly mixed in water uniformly, the dosage of the water is above-mentioned raw materials gross mass
15%, obtain a kind of horseradish ferment toothpaste.
Embodiment 4
A kind of preparation method of horseradish ferment toothpaste, including：
A. take horseradish root, freeze 16h after cleaning at -18 DEG C, after through pulverizing and sieving, collection cut size be 3 μm or less
Horseradish powder；
B. 15 parts of glycerine, 23 parts of sorbierite, 1 part of carboxymethyl cellulose, 5 parts of hydroxyethyl cellulose, dodecane are weighed respectively
1 part of base sodium sulphate, 0.5 part of dodecanoyl sodium sarcosinate, 14 parts of Silica Using for Toothpaste, 2 parts of serrapeptass, alpha-amylase 0.4
Part, 0.7 part of pancreatic lipase, 0.4 part of horseradish powder, 0.5 part of peppermint oil and 1 part of tri-chloro galactose type sugar；
C. above-mentioned raw materials are thoroughly mixed in water uniformly, the dosage of the water is above-mentioned raw materials gross mass
25%, obtain a kind of horseradish ferment toothpaste.
Embodiment 5
A kind of preparation method of horseradish ferment toothpaste, including：
A. take horseradish root, freeze 18h after cleaning at -15 DEG C, after through pulverizing and sieving, collection cut size be 1 μm or less
Horseradish powder；
B. 20 parts of glycerine, 15 parts of sorbierite, 2 parts of carboxymethyl cellulose, 3 parts of hydroxyethyl cellulose, dodecane are weighed respectively
0.5 part of base sodium sulphate, 0.5 part of dodecanoyl sodium sarcosinate, 12 parts of Silica Using for Toothpaste, 1.5 parts of serrapeptass, alpha-amylase
0.5 part of 0.3 part, 0.5 part of pancreatic lipase, 0.3 part of horseradish powder, 0.5 part of eugenol and saccharin sodium；
C. above-mentioned raw materials are thoroughly mixed in water uniformly, the dosage of the water is above-mentioned raw materials gross mass
20%, obtain a kind of horseradish ferment toothpaste.
Comparative example 1-5
A kind of preparation method of toothpaste, including：
Raw material and method described in embodiment 1-5 are respectively adopted successively, a kind of horseradish ferment toothpaste is prepared, difference exists
In without using horseradish powder.
Comparative example 6-10
A kind of preparation method of toothpaste, including：
Raw material and method described in embodiment 1-5 are respectively adopted successively, a kind of horseradish ferment toothpaste is prepared, difference exists
In without using serrapeptass, alpha-amylase and pancreatic lipase.
Comparative example 11-14
A kind of preparation method of toothpaste, including：
Raw material described in embodiment 1 is respectively adopted successively and a kind of horseradish ferment toothpaste is prepared in method, difference lies in
It is 8 μm or less, 5 μm or less, 3 μm or less, 1 μm of horseradish powder below that grain size is respectively adopted in comparative example 6-9 successively.
Performance detection is carried out to toothpaste obtained by various embodiments of the present invention and comparative example.
Biocidal property is tested：
Strain：Treponema denticola, porphyromonas gingivalis, streptococcus mutans, Streptococcus sanguis, Escherichia coli, white chain
Pearl bacterium；
The preparation of antibacterial sample：Sample toothpaste 1.0g is weighed, 3mL deionized waters are added and stir evenly, obtain toothpaste fluid；
Test method：By treponema denticola microbionation in two agar plates A, B (inoculum density be 200 ±
10/mL), educational standards 35mm × 35mm × 10mm, upper liquid measure is 3mL, and the toothpaste of 1mL is uniformly sprayed into wherein culture medium B
Liquid after being then placed on culture dish A, B in the incubator that temperature is 37 DEG C for 24 hours, observes the visible bacterium of two kinds of culture medium naked eyes respectively
Number is fallen, and calculates the bacteriostasis rate of mouthwash.Test method and the treponema denticola phase of porphyromonas gingivalis, streptococcus mutans
Together.
Bacteriostasis rate computational methods are：Bacteriostasis rate=(clump count A- clump count B)/clump count A × 100%, as a result such as 1 institute of table
Show：
1 horseradish ferment toothpaste bacteriostasis rate of the present invention of table
Dental caries therapeutic effect：
Test method：Select purebred Wi star big white mouse, half male and half female, 55 ± 5g of weight, be equally divided into it is multigroup, often
Group 20, every group corresponds to one embodiment or comparative example respectively, and streptococcus mutans are put into TSB enrichment liquids and are cultivated, and (culture is close
Degree is 50 ± 5/mL), it cultivates 24 hours, then picks enrichment liquid with swab stick and embrocate in the alveolus ground one's teeth in sleep under big white mouse
(inoculation is primary weekly), selects sucrose to feed, and raises two months, wherein during raising, every group of every morning 6:00 uses cotton
Stick picks a kind of toothpaste (0.3mL toothpaste) and embrocates in the alveolus ground one's teeth in sleep under big white mouse, and remaining one group is not embrocated toothpaste (control
Group), a situation arises for observation saprodontia, and the results are shown in Table 2.
2 horseradish ferment toothpaste dental caries therapeutic effect of the present invention of table
| Embodiment | Morbidity of dental caries | The equal saprodontia number of mouse | Dental caries damage number |
| Embodiment 1 | 0 | 0 | 0 |
| Embodiment 2 | 0 | 0 | 0 |
| Embodiment 3 | 0 | 0 | 0 |
| Embodiment 4 | 0 | 0 | 0 |
| Embodiment 5 | 0 | 0 | 0 |
| Comparative example 1 | 15% | 0.35 | 3 |
| Comparative example 2 | 13% | 0.32 | 3 |
| Comparative example 3 | 12% | 0.30 | 2 |
| Comparative example 4 | 11% | 0.29 | 2 |
| Comparative example 5 | 10% | 0.27 | 2 |
| Comparative example 6 | 25% | 0.45 | 8 |
| Comparative example 7 | 23% | 0.42 | 7 |
| Comparative example 8 | 21% | 0.40 | 7 |
| Comparative example 9 | 20% | 0.39 | 6 |
| Comparative example 10 | 19% | 0.37 | 6 |
| Comparative example 11 | 0 | 0 | 0 |
| Comparative example 12 | 0 | 0 | 0 |
| Comparative example 13 | 0 | 0 | 0 |
| Comparative example 14 | 0 | 0 | 0 |
| Control group | 95% | 2.35 | 47 |
By Tables 1 and 2 as can be seen that horseradish ferment toothpaste of the present invention has excellent antibacterial bacteriostatic effect.Compared to it
Under, do not use toothpaste prepared by horseradish ingredient that also there is certain antibacterial bacteriostatic effect, but be significantly lower than horseradish ferment of the present invention
Toothpaste；Without the toothpaste being prepared using ferment ingredient, antibacterial bacteriostatic effect is limited, although horseradish itself also has centainly
Antibacterial effect, but its dosage is less, cannot play ideal effect.Horseradish ferment toothpaste of the present invention is by horseradish and ferment ingredient knot
It closes and uses, significant synergistic effect is played in terms of antibacterial bacteriostatic effect.Meanwhile the grain size of horseradish powder is further decreased,
Show the trend that gained toothpaste antibacterial bacteriostatic effect further increases.
Use test：
Choosing has the patient of at least one symptoms such as tooth jaundice, teeth stains and halitosis, as experimenter, age point
It is distributed in 30-50 Sui.It is randomly divided into multigroup, every group corresponds to one embodiment or comparative example, every group of 40 people respectively.Every experimenter
It brushes teeth 2 times daily, once in the morning and once at night, each 3-5mi n, there was no significant difference between the amount of toothpaste used every time for everyone, uses
Method is consistent with ordinary toothpaste, as a treatment course with 1 month.Tester according to oneself feel carry out evaluation scoring.Scoring mark
Standard uses ten point system, and 1 point worst, as uses front and back unchanged；10 points best, is as significantly improved using rear symptom.In addition,
Implication value of each experimenter after a course for the treatment of is measured using implication test equipment.The results are shown in Table 3：
3 horseradish ferment toothpaste saprodontia using effect of the present invention of table
It can be seen from Table 3 that horseradish ferment toothpaste of the present invention can significantly improve the diseases such as tooth jaundice and color spot, halitosis
Shape reduces implication value, has excellent cleaning efficacy.In contrast, toothpaste prepared by horseradish ingredient is not used to send out tooth
The improvement of the symptoms such as yellow and color spot, halitosis is limited, and the reduction of implication value is limited, and used ferment ingredient is only capable of cooperation mill
Liniment ingredient, improves cleaning effect to a certain extent；Toothpaste without being prepared using ferment ingredient turns to be yellow for tooth
And the symptoms such as color spot, halitosis, substantially without improvement, implication value does not reduce substantially, be only capable of by contained abrasive at
Divide and play certain cleaning effect, cleaning capacity is less than the tooth paste product using ferment ingredient.Due to used in the present invention
Abrasive dosage is less, therefore does not use horseradish ingredient or do not use toothpaste obtained by ferment ingredient, relies primarily on abrasive progress
The played cleaning effect of cleaning is poor.Horseradish is used in combination horseradish ferment toothpaste of the present invention with ferment ingredient, is improving tooth
Tooth turns to be yellow and the symptoms such as color spot, halitosis, reduces implication value, improves cleaning effect etc. and plays significant synergistic effect,
Under the cooperation of horseradish, various ferment ingredients give full play of cleaning efficacy.Meanwhile the grain size of horseradish powder is further decreased, also it is in
Revealing gained toothpaste improves the symptoms such as tooth jaundice and color spot, halitosis, reduces implication value, improves what cleaning effect further increased
Trend.
Although illustrate and describing the present invention with specific embodiment, it will be appreciated that the above various embodiments is only used
To illustrate technical scheme of the present invention, rather than its limitations；It will be understood by those of ordinary skill in the art that：Without departing substantially from this hair
It, can be with technical scheme described in the above embodiments is modified, or to wherein in the case of bright spirit and scope
Some or all of technical characteristic carries out equivalent replacement；And these modifications or replacements, do not make the essence of corresponding technical solution
It departs from the scope of the technical solutions of the embodiments of the present invention；It is, therefore, intended that including belonging to the present invention in the following claims
All these substitutions and modifications in range.
Claims (10)
1. a kind of horseradish ferment toothpaste, which is characterized in that the horseradish ferment toothpaste is mainly by the ingredient of following mass fraction meter
It is prepared：
30-40 parts of moisturizer, 2-8 parts of thickener, 0.1-2 parts of foaming agent, 10-15 parts of additive, 0.5-3 parts of serrapeptass, α-
0.1-2 parts of 0.1-0.5 parts of amylase, 0.1-1 parts of pancreatic lipase, 0.1-0.5 parts of horseradish powder and flavoring agent.
2. a kind of horseradish ferment toothpaste according to claim 1, which is characterized in that the horseradish ferment toothpaste mainly by with
The ingredient of lower mass fraction meter is prepared：
32-38 parts of moisturizer, 4-6 parts of thickener, 0.5-1.5 parts of foaming agent, 11-14 parts of additive, 1-2 parts of serrapeptass, α-
0.5-1.5 parts of 0.2-0.4 parts of amylase, 0.3-0.7 parts of pancreatic lipase, 0.2-0.4 parts of horseradish powder and flavoring agent；
Preferably, the horseradish ferment toothpaste is mainly prepared by the ingredient of following mass fraction meter：
35 parts of moisturizer, 5 parts of thickener, 1 part of foaming agent, 12 parts of additive, 1.5 parts of serrapeptass, 0.3 part of alpha-amylase, pancreas
1 part of 0.5 part of lipase, 0.3 part of horseradish powder and flavoring agent.
3. a kind of horseradish ferment toothpaste according to claim 1, which is characterized in that the preparation of the horseradish powder ferment toothpaste
Raw material further includes water；
Optionally, the dosage of the water be the moisturizer, thickener, additive, serrapeptass, alpha-amylase, pancreatic lipase,
The 10%-30% of horseradish powder and flavoring agent gross mass, preferably 15%-25%, further preferably 20%.
4. a kind of horseradish ferment toothpaste according to claim 1, which is characterized in that the moisturizer includes alcohols moisturizer
In it is one or more, preferably include glycerine and/or sorbierite.
5. a kind of horseradish ferment toothpaste according to claim 1, which is characterized in that the thickener includes that cellulose family increases
It is one or more in thick dose, preferably include carboxymethyl cellulose and/or hydroxyethyl cellulose.
6. a kind of horseradish ferment toothpaste according to claim 1, which is characterized in that the additive includes in rubbing agent
It is one or more, preferably include silica.
7. a kind of horseradish ferment toothpaste according to claim 1, which is characterized in that the flavoring agent preferably includes aromatic
With it is one or more in sweetener；
Optionally, the aromatic includes one or more in Thymol, eugenol and peppermint oil；
Optionally, the sweetener includes one or more in saccharin sodium, aspartame, stevioside and tri-chloro galactose type sugar；
Optionally, the foaming agent includes lauryl sodium sulfate and/or dodecanoyl sodium sarcosinate.
8. a kind of preparation method of horseradish ferment toothpaste as described in claim 1-7 is any, which is characterized in that including：
Moisturizer, thickener, additive, serrapeptass, alpha-amylase, pancreatic lipase, horseradish powder and flavoring agent are filled in proportion
Divide and be uniformly mixed, obtains a kind of horseradish powder ferment toothpaste.
9. a kind of preparation method of horseradish ferment toothpaste according to claim 8, which is characterized in that including：
In proportion by moisturizer, thickener, additive, serrapeptass, alpha-amylase, pancreatic lipase, horseradish powder, flavoring agent and water
It is thoroughly mixed uniformly, obtains a kind of horseradish powder ferment toothpaste.
10. a kind of preparation method of horseradish ferment toothpaste according to claim 8 or claim 9, which is characterized in that the horseradish powder
Preparation method include：
It is crushed after horseradish root is freezed, obtains horseradish powder；
Optionally, the horseradish root is crushed to grain size as 10 μm hereinafter, preferably 1 μm or less.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103263376A (en) * | 2013-05-30 | 2013-08-28 | 成都大学 | Horseradish toothpaste and preparation method thereof |
| CN103876983A (en) * | 2014-03-22 | 2014-06-25 | 南通蛇类治疗研究所 | Ferment enzyme toothpaste |
| CN104958188A (en) * | 2015-06-10 | 2015-10-07 | 鄢德阳 | Composite ferment toothpaste and preparation method thereof |
-
2018
- 2018-04-24 CN CN201810372782.XA patent/CN108420761A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103263376A (en) * | 2013-05-30 | 2013-08-28 | 成都大学 | Horseradish toothpaste and preparation method thereof |
| CN103876983A (en) * | 2014-03-22 | 2014-06-25 | 南通蛇类治疗研究所 | Ferment enzyme toothpaste |
| CN104958188A (en) * | 2015-06-10 | 2015-10-07 | 鄢德阳 | Composite ferment toothpaste and preparation method thereof |
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