CN108410594B - Medical foaming enzyme humectant and preparation method thereof - Google Patents
Medical foaming enzyme humectant and preparation method thereof Download PDFInfo
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- CN108410594B CN108410594B CN201810182714.7A CN201810182714A CN108410594B CN 108410594 B CN108410594 B CN 108410594B CN 201810182714 A CN201810182714 A CN 201810182714A CN 108410594 B CN108410594 B CN 108410594B
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- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
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- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
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- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
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- C11D3/16—Organic compounds
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- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
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- C11D3/38—Products with no well-defined composition, e.g. natural products
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- C11D3/38618—Protease or amylase in liquid compositions only
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- C11D3/38—Products with no well-defined composition, e.g. natural products
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- C11D3/38627—Preparations containing enzymes, e.g. protease or amylase containing lipase
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- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38636—Preparations containing enzymes, e.g. protease or amylase containing enzymes other than protease, amylase, lipase, cellulase, oxidase or reductase
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- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38645—Preparations containing enzymes, e.g. protease or amylase containing cellulase
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- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/02—Anionic compounds
- C11D1/12—Sulfonic acids or sulfuric acid esters; Salts thereof
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Abstract
The invention discloses a medical foaming enzyme humectant and a preparation method thereof, wherein the medical foaming enzyme humectant comprises the following components in percentage by mass: 1 to 8 percent of anionic surfactant foaming agent, 2 to 10 percent of amphoteric surfactant foaming agent, 0.2 to 2.0 percent of compound biological enzyme, 3.0 to 10.0 percent of high molecular polymer humectant, 2.0 to 10.0 percent of solubilizer, 2.0 to 5.0 percent of compound corrosion inhibitor, 0.3 to 2.5 percent of foam stabilizer and the balance of water. The novel pollution-free environment-friendly medical foaming enzyme humectant provided by the invention adopts an acidic and chlorinated compound-free formula, is neutral, and has no corrosion to carbon steel, stainless steel and the like. The invention aims to provide an environment-friendly medical foaming enzyme humectant which is environment-friendly, convenient to use, obvious in effect and free of pollution.
Description
Technical Field
The invention relates to the technical field of novel medical foaming enzyme humectant compositions, in particular to a medical foaming enzyme humectant and a preparation method thereof.
Background
The existing moisturizers comprise a gel moisturizer and a foam moisturizer, and the action principle of the moisturizer is that pollutants on instruments and appliances are kept to have certain wettability by blocking air through gel or foam, so that the subsequent procedure is convenient to operate. The gel humectant liquid has certain viscosity, is inconvenient to use, and is not as good as the foam humectant can quickly cover the surface of an apparatus. Most of the current foam moisturizers are used for beating foam by means of efficient pressing of foaming pump heads, foam is broken and defoamed within two to three hours of foam duration, instruments subjected to operation in a hospital are generally subjected to centralized treatment, some intervals are 4 hours, especially in night operation, the instruments are cleaned in the next day, the cleaning intervals reach 12 hours or longer, and the effectiveness of existing products in the market is very difficult to meet the requirement of the practical phenomenon.
The moisture retention refers to a process of keeping the contaminants (including blood, tissue, protein, and the like) and part of the microorganisms attached to the surfaces of the medical instruments, instruments and articles moist and avoiding drying for the reason of centralized cleaning, so as to lay a good foundation for the next link of efficient and rapid thorough cleaning.
In the using process of the medical apparatus, due to continuous contact with a human body, a large amount of blood, fat, starch and other dirt are carried, a biomembrane tissue is attached, the conventional cleaning procedure is to be cleaned and treated regularly and intensively, various pollutants have serious erosion on the medical apparatus and the instrument in the period, and the cleaning of various pollutants after drying and curing wastes time and labor, so that the apparatus and the instrument are protected from being corroded and can be kept wet to a certain extent, and the subsequent work charging operation is easy, and a high-efficiency moisture-preserving product and a high-efficiency moisture-preserving method are needed to meet the requirement.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a medical foaming enzyme humectant and a preparation method thereof, aiming at solving the technical problems that the prior art can not have the effects of cleaning and long-time moisture preservation (the foam has long persistence and the defoaming time is more than 24 hours), and has no corrosion to carbon steel, stainless steel and other apparatuses and appliances.
In order to solve the problems, the invention discloses a medical foaming enzyme humectant which comprises the following components in percentage by mass: 1-8% of anionic surfactant foaming agent, 2-10% of amphoteric surfactant foaming agent, 0.2-2.0% of compound biological enzyme preparation, 3.0-10.0% of high molecular polymer humectant, 2.0-10.0% of solubilizer, 2.0-5.0% of compound corrosion inhibitor, 0.3-2.5% of foam stabilizer and the balance of water.
Preferably, the medical foaming enzyme humectant comprises the following components in percentage by mass: 3.0-6.0 percent of anionic surfactant foaming agent, 5.0-8.0 percent of amphoteric surfactant foaming agent, 1.0-1.5 percent of compound biological enzyme preparation, 5.0-8.0 percent of high molecular polymer humectant, 5.0-8.0 percent of solubilizer, 3.0-4.0 percent of compound corrosion inhibitor, 1.0-2.0 percent of foam stabilizer and the balance of water. Further preferably 4.0-5.0% of anionic surfactant foaming agent, 6.0-7.0% of amphoteric surfactant foaming agent, 1.2-1.4% of composite biological enzyme preparation, 6.0-7.0% of high molecular polymer humectant, 6.0-7.0% of solubilizer, 3.5-3.8% of composite corrosion inhibitor, 1.2-1.8% of foam stabilizer and the balance of water.
Preferably, the foaming agent is selected from a mixture of three to five of anionic surfactants and amphoteric surfactants, the mixing ratio therebetween is not limited, and when three are selected, the preferred mass ratio is equivalent or the preferred mass ratio therebetween is 3: 4.2: 4.8.
preferably, the high molecular polymer humectant is one selected from alpha-hydrogen-omega-hydroxyl (oxy-1, 2-ethanediyl) polymers.
Preferably, the complex bio-enzyme preparation is a mixture of two or more selected from the group consisting of protease, lipase, amylase, cellulase, pectinase, RNA polymerase, and hydrolase, and the mixing ratio of the two or more is not limited, preferably 4: 1: 1.4.
preferably, the solubilizer is selected from one of propylene glycol, ethanol, dipropylene glycol butyl ether or isopropanol.
Preferably, the corrosion inhibitor is one of imidazoline, amino acid and inorganic corrosion inhibitors, and is an environment-friendly chemical with good biodegradability.
Preferably, the foam stabilizer is one of polyether foam stabilizers, natural pectin foam stabilizers and protein foam stabilizers.
In order to solve the problems, the invention also discloses a preparation method of the novel medical foaming enzyme humectant, which comprises the steps of adding all or 50-60% of the water in the formula or the mass ratio of all the water in the formula, then sequentially adding an anionic surfactant, an amphoteric surfactant, a compound biological enzyme, a high-molecular polymer humectant, a solubilizer, a compound corrosion inhibitor and a foam stabilizer into water, supplementing the rest water, and continuously stirring until all the water is dissolved to obtain the medical foaming enzyme humectant.
The invention has the following beneficial effects:
the environment-friendly medical foaming enzyme humectant provided by the invention is prepared by compounding a composite biological enzyme preparation, an environment-friendly solvent and a surfactant, adopts a phosphorus-free formula, does not contain a fluorescent whitening agent, an acid and alkali, and a chlorine-containing organic matter, is environment-friendly, has a biodegradation rate of more than 90%, is non-toxic and harmless, and has an antistatic property; the moisture retention process has no corrosion and no damage to the instruments; the medical instrument has the characteristics of easy flushing and high-efficiency cleaning, and can decompose or soften blood stain, protein, mucopolysaccharide, carbohydrate, fat and other mixed pollutants on the inner surface and the outer surface of the surgical instrument in the moisturizing process, so that the moisturizing requirement and the cleaning effect are met, and the standard requirement of the domestic medical instrument pretreatment link is met; the product has good foaming effect of the conventional foam nozzle, and is easy to foam manually or mechanically. The process formula of the environment-friendly medical foaming enzyme humectant can be prepared at normal temperature, so that heat energy is saved; the performance is stable, the foaming power is good, and the cleaning function is achieved, so that mixed pollutants such as blood stain, fat and the like on surgical instruments can be kept in a closed environment for a long time and isolated from air, and the moisture is preserved in all directions.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.
Example 1
The embodiment provides a novel medical foaming enzyme humectant which comprises the following components in percentage by mass:
product name | Mass percent% | Product name | Mass percent% |
Anionic surface-active foaming agent | 3.0 | High molecular polymer humectant | 6.0 |
Amphoteric surface-active foaming agents | 8.0 | Composite corrosion inhibitor | 5.0 |
Composite biological enzyme preparation | 0.5 | Foam stabilizer | 1.0 |
Solubilizer | 4.0 | RO pure water | 72.5 |
Wherein the compound biological enzyme preparation is selected from more than two of protease, lipase, amylase, cellulase, pectinase, RNA polymerase and hydrolase. In the embodiment, protease, lipase, amylase and pectinase can be adopted, and the mass ratio is 6: 2: 1: 1; or protease, lipase, amylase and cellulase are adopted, and the mass ratio is 5: 2: 1.5: 1.5; or protease and lipase are adopted, and the mass ratio is 6: 4; or protease, lipase, amylase, pectinase and RNA polymerase are adopted, and the mass ratio is 5: 2: 1: 1: 1; or protease, lipase, amylase, cellulase, pectinase, RNA polymerase and hydrolase are adopted, and the mass ratio is 4: 1.5: 2: 0.5: 1: 0.75: 0.25, etc.
In this embodiment, the solubilizer may be propylene glycol, ethanol, butyl diglycol or isopropanol.
The humectant in this embodiment may be food-grade high molecular polymer, such as: glycerol, ethylene glycol, propylene glycol or polyethylene glycol.
The foaming agent in this embodiment is selected from any one of an anionic surfactant and an amphoteric surfactant or a mixture of three to five of the anionic surfactant and the amphoteric surfactant, and the mass ratio of the foaming agent to the amphoteric surfactant is not limited, for example: sodium alpha-olefin sulfonate, secondary alkyl sodium sulfonate, ethoxylated alkyl sodium sulfate, dodecyl betaine, cocamidopropyl amine oxide, disodium lauryl sulfosuccinate, potassium monododecyl phosphate.
Wherein, the polymer humectant in this embodiment is selected from one of the polymers of α -hydro- ω -hydroxy (oxy-1, 2-ethanediyl), such as: polyethylene glycol 200, polyethylene glycol 400, polyethylene glycol 600 or polyethylene glycol 2000.
The corrosion inhibitor in the embodiment is one of imidazoline, amino acid and inorganic corrosion inhibitors, and is an environment-friendly chemical with good biodegradability.
The foam stabilizer in this embodiment is one selected from a polyether foam stabilizer, a natural pectin foam stabilizer, and a protein foam stabilizer.
The preparation method of the novel medical foaming enzyme humectant comprises the following steps:
firstly, 50% of the water amount of the formula is added into a container, an anionic surfactant, an amphoteric surfactant, a compound bio-enzyme preparation, a polymer humectant, a solubilizer, a corrosion inhibitor and a foam stabilizer are sequentially added, the rest water is replenished, and the mixture is continuously stirred until the mixture is completely dissolved, so that the water-soluble organic silicon gel is obtained.
The invention discloses a novel medical foaming enzyme humectant foam duration test method which comprises the following steps:
1. duration of foam
(1) Placing a surgical instrument in a square tray, spraying medical foaming enzyme humectant with a common foam nozzle, and directly spraying the medical foaming enzyme humectant in the square tray, wherein the instrument is covered by spraying foam for 50 times.
(2) Placing two round carbon steel sheets in the same square tray, spraying medical foaming enzyme humectant with common foam nozzle, and directly spraying for 50 times.
(3) After the bubbles are sprayed on each square tray for 50 times, a stopwatch is pressed to start timing, the first recording time is that the bubbles are exposed out of the surgical instrument, and the final recording time is that the bubbles are completely broken;
(4) and after the time reaches 5 hours, taking out the round carbon steel sheet by using tweezers, directly washing the round carbon steel sheet by using soft water, drying the round carbon steel sheet in an oven at the temperature of 45 ℃ for 20 minutes, drying water stains, and observing and measuring the appearance and the quality of the round carbon steel sheet.
And (3) test results:
1. the round carbon steel sheet has no appearance change, no stain, no corrosion and no quality loss.
2. The foam lasts for 12 hours at 1 st; the 2 nd time for complete disappearance of foam was 48 hours.
And (3) test results: the novel medical foaming enzyme humectant disclosed by the invention has long foam duration and does not corrode carbon steel and stainless steel instruments.
Example 2
The embodiment provides a novel medical foaming enzyme humectant which comprises the following components in percentage by mass:
product name | Mass percent% | Product name | Mass percent% |
Anionic surface-active foaming agent | 5.0 | High molecular polymer humectant | 5.0 |
Amphoteric surface-active foaming agents | 6.0 | Composite corrosion inhibitor | 2.5 |
Composite biological enzyme preparation | 1.0 | Foam stabilizer | 2.0 |
Solubilizer | 8.0 | RO pure water | 70.5 |
Wherein the compound biological enzyme preparation is selected from more than two of protease, lipase, amylase, cellulase, pectinase, RNA polymerase and hydrolase. Proteases, lipases, amylases, and pectinases may be used in this example; or protease, lipase, amylase and cellulase; or protease and lipase; or protease, lipase, amylase, pectinase and RNA polymerase; or a combination of protease, lipase, amylase, cellulase, pectinase, RNA polymerase, hydrolase, etc.
In this embodiment, the solubilizer may be propylene glycol, ethanol, butyl diglycol or isopropanol.
The humectant in this embodiment may be a food-grade polymer.
Wherein, the foaming agent in the embodiment is selected from three to five of anionic surfactant and amphoteric surfactant.
In this embodiment, the polymer humectant is selected from one of α -hydro- ω -hydroxy (oxy-1, 2-ethanediyl) polymers.
The corrosion inhibitor in the embodiment is one of imidazoline, amino acid and inorganic corrosion inhibitors, and is an environment-friendly chemical with good biodegradability.
The foam stabilizer in the embodiment is a compound of amphoteric surface active and modified polyether.
The preparation method of the novel medical foaming enzyme humectant comprises the following steps:
firstly, 55% of the water amount of the formula is added into a container, an anionic surfactant, an amphoteric surfactant, a compound bio-enzyme preparation, a polymer humectant, a solubilizer, a corrosion inhibitor and a foam stabilizer are sequentially added, the rest water is replenished, and the mixture is continuously stirred until the mixture is completely dissolved, so that the water-soluble organic silicon gel is obtained.
The rest is the same as that described in embodiment 1, and will not be described herein.
Example 3
The embodiment provides a novel medical foaming enzyme humectant which comprises the following components in percentage by mass:
product name | Mass percent% | Product name | Mass percent% |
Anionic surface-active foaming agent | 2.0 | High molecular polymer humectant | 8.0 |
Amphoteric surface-active foaming agents | 4.5 | Composite corrosion inhibitor | 2.0 |
Composite biological enzyme preparation | 1.0 | Foam stabilizer | 2.5 |
Solubilizer | 7.5 | RO pure water | 72.5 |
Wherein the compound biological enzyme preparation is selected from more than two of protease, lipase, amylase, cellulase, pectinase, RNA polymerase and hydrolase. Proteases, lipases, amylases, and pectinases may be used in this example; or protease, lipase, amylase and cellulase; or protease and lipase; or protease, lipase, amylase, pectinase and RNA polymerase; or a combination of protease, lipase, amylase, cellulase, pectinase, RNA polymerase, hydrolase, etc.
In this embodiment, the solubilizer may be propylene glycol, ethanol, butyl diglycol or isopropanol.
The humectant in this embodiment may be a food-grade polymer.
Wherein, the foaming agent in the embodiment is selected from three to five of anionic surfactant and amphoteric surfactant.
In this embodiment, the polymer humectant is selected from one of α -hydro- ω -hydroxy (oxy-1, 2-ethanediyl) polymers.
The corrosion inhibitor in the embodiment is one of amino acids, and is an environment-friendly chemical with good biodegradability.
The foam stabilizer in the embodiment is a compound of amphoteric surface active and modified polyether.
The preparation method of the novel medical foaming enzyme humectant comprises the following steps:
firstly, 60% of the water amount of the formula is added into a container, an anionic surfactant, an amphoteric surfactant, a compound bio-enzyme preparation, a polymer humectant, a solubilizer, a corrosion inhibitor and a foam stabilizer are sequentially added, the rest water is replenished, and the mixture is continuously stirred until the mixture is completely dissolved, so that the water-soluble organic silicon gel is obtained.
The rest is the same as that described in embodiment 1, and will not be described herein.
Example 4
The embodiment provides a novel medical foaming enzyme humectant which comprises the following components in percentage by mass:
product name | Mass percent% | Product name | Mass percent% |
Anionic surface-active foaming agent | 1.0 | High molecular polymer humectant | 10.0 |
Amphoteric surface-active foaming agents | 2.0 | Composite corrosion inhibitor | 3.0 |
Composite biological enzyme preparation | 0.2 | Foam stabilizer | 0.3 |
Solubilizer | 2.0 | RO pure water | 81.5 |
The selection of the types of reagents is the same as that in example 1, and the preparation method is also the same as that in example 1, and the details are not repeated here. And (3) test results: the medical foaming enzyme humectant disclosed by the embodiment has long foam duration and does not corrode carbon steel and stainless steel instruments.
Example 5
The embodiment provides a novel medical foaming enzyme humectant which comprises the following components in percentage by mass:
product name | Mass percent% | Product name | Mass percent% |
Anionic surface-active foaming agent | 8.0 | High molecular polymer humectant | 7.0 |
Amphoteric surface-active foaming agents | 10.0 | Composite corrosion inhibitor | 4.0 |
Composite biological enzyme preparation | 2.0 | Foam stabilizer | 1.2 |
Solubilizer | 10.0 | RO pure water | 57.8 |
The selection of the types of reagents is the same as that in example 1, and the preparation method is also the same as that in example 1, and the details are not repeated here. The medical foaming enzyme humectant disclosed by the embodiment has long foam duration and does not corrode carbon steel and stainless steel instruments.
Example 6
The embodiment provides a novel medical foaming enzyme humectant which comprises the following components in percentage by mass:
product name | Mass percent% | Product name | Mass percent% |
Anionic surface-active foaming agent | 4.0 | High molecular polymer humectant | 3.0 |
Amphoteric surface-active foaming agents | 5.0 | Composite corrosion inhibitor | 3.5 |
Composite biological enzyme preparation | 1.2 | Foam stabilizer | 1.5 |
Solubilizer | 5.0 | RO pure water | 76.8 |
The selection of the types of reagents is the same as that in example 1, and the preparation method is also the same as that in example 1, and the details are not repeated here. The medical foaming enzyme humectant disclosed by the embodiment has long foam duration and does not corrode carbon steel and stainless steel instruments.
Example 7
The embodiment provides a novel medical foaming enzyme humectant which comprises the following components in percentage by mass:
product name | Mass percent% | Product name | Mass percent% |
Anionic surface-active foaming agent | 6.0 | High molecular polymer humectant | 4.0 |
Amphoteric surface-active foaming agents | 7.0 | Composite corrosion inhibitor | 3.8 |
Composite biological enzyme preparation | 1.5 | Foam stabilizer | 1.8 |
Solubilizer | 6.0 | RO pure water | 69.9 |
The selection of the types of reagents is the same as that in example 1, and the preparation method is also the same as that in example 1, and the details are not repeated here. The medical foaming enzyme humectant disclosed by the embodiment has long foam duration and does not corrode carbon steel and stainless steel instruments.
The above is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and various modifications and changes will occur to those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (3)
1. The medical foaming enzyme humectant is characterized by comprising the following components in percentage by mass: 1-8% of anionic surfactant foaming agent, 2-10% of amphoteric surfactant foaming agent, 0.2-2.0% of compound biological enzyme preparation, 3.0-10.0% of high molecular polymer humectant, 2.0-10.0% of solubilizer, 2.0-5.0% of compound corrosion inhibitor, 0.3-2.5% of foam stabilizer and the balance of water;
the foaming agent is selected from a mixture formed by three to five of anionic surfactant and amphoteric surfactant;
the compound biological enzyme preparation is a mixture formed by more than two of protease, lipase, amylase, cellulase, pectinase, RNA polymerase and hydrolase; the composite biological enzyme preparation adopts protease, lipase, amylase and pectinase, and the mass ratio is 6: 2: 1: 1; or protease, lipase, amylase and cellulase are adopted, and the mass ratio is 5: 2: 1.5: 1.5; or protease, lipase, amylase, pectinase and RNA polymerase are adopted, and the mass ratio is 5: 2: 1: 1: 1; or protease, lipase, amylase, cellulase, pectinase, RNA polymerase and hydrolase are adopted, and the mass ratio is 4: 1.5: 2: 0.5: 1: 0.75: 0.25;
the high molecular polymer humectant is one selected from alpha-hydrogen-omega-hydroxyl (oxygen-1, 2-ethanediyl) polymers;
the solubilizer is selected from one of propylene glycol, ethanol, dipropylene glycol butyl ether or isopropanol;
the corrosion inhibitor is one of imidazoline, amino acid and inorganic corrosion inhibitors;
the foam stabilizer is a polyether foam stabilizer.
2. The medical foaming enzyme humectant according to the claim 1, characterized in that, by mass percentage, it comprises the following components: 3.0-6.0 percent of anionic surfactant foaming agent, 5.0-8.0 percent of amphoteric surfactant foaming agent, 1.0-1.5 percent of compound biological enzyme preparation, 5.0-8.0 percent of high molecular polymer humectant, 5.0-8.0 percent of solubilizer, 3.0-4.0 percent of compound corrosion inhibitor, 1.0-2.0 percent of foam stabilizer and the balance of water.
3. The method for preparing the medical foaming enzyme moisturizer as claimed in any one of claims 1 to 2, which is characterized in that: adding 50-60% of the total amount of the formula water or the mass ratio, then sequentially adding an anionic surfactant, an amphoteric surfactant, a compound biological enzyme preparation, a polymer humectant, a solubilizer, a corrosion inhibitor and a foam stabilizer into the water, supplementing the rest of the water, and continuously stirring until the components are completely and uniformly dissolved to obtain the medical foaming enzyme humectant.
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CN104073323B (en) * | 2013-12-05 | 2016-08-31 | 老肯医疗科技股份有限公司 | A kind of lubricant being applicable to medicine equipment and preparation method |
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CN105154251A (en) * | 2015-10-16 | 2015-12-16 | 青岛海之星生物科技有限公司 | Foam cleaning composition |
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US6235692B1 (en) * | 1998-08-26 | 2001-05-22 | Cottrell International, Llc | Foaming enzyme spray cleaning composition and method of delivery |
EP0994178B1 (en) * | 1998-10-15 | 2003-02-05 | B. Braun Medical AG | Cleaning compositions and their use |
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