CN108410594B - Medical foaming enzyme humectant and preparation method thereof - Google Patents

Medical foaming enzyme humectant and preparation method thereof Download PDF

Info

Publication number
CN108410594B
CN108410594B CN201810182714.7A CN201810182714A CN108410594B CN 108410594 B CN108410594 B CN 108410594B CN 201810182714 A CN201810182714 A CN 201810182714A CN 108410594 B CN108410594 B CN 108410594B
Authority
CN
China
Prior art keywords
humectant
percent
foaming
enzyme
medical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201810182714.7A
Other languages
Chinese (zh)
Other versions
CN108410594A (en
Inventor
周祺
伍川
崔丽平
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing Jiashili Technology Co ltd
Original Assignee
Beijing Jiashili Technology Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Jiashili Technology Co ltd filed Critical Beijing Jiashili Technology Co ltd
Priority to CN201810182714.7A priority Critical patent/CN108410594B/en
Publication of CN108410594A publication Critical patent/CN108410594A/en
Application granted granted Critical
Publication of CN108410594B publication Critical patent/CN108410594B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/88Ampholytes; Electroneutral compounds
    • C11D1/94Mixtures with anionic, cationic or non-ionic compounds
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005Other compounding ingredients characterised by their effect
    • C11D3/001Softening compositions
    • C11D3/0015Softening compositions liquid
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005Other compounding ingredients characterised by their effect
    • C11D3/0094High foaming compositions
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/20Organic compounds containing oxygen
    • C11D3/2003Alcohols; Phenols
    • C11D3/2006Monohydric alcohols
    • C11D3/201Monohydric alcohols linear
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/20Organic compounds containing oxygen
    • C11D3/2003Alcohols; Phenols
    • C11D3/2006Monohydric alcohols
    • C11D3/2017Monohydric alcohols branched
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/20Organic compounds containing oxygen
    • C11D3/2003Alcohols; Phenols
    • C11D3/2041Dihydric alcohols
    • C11D3/2044Dihydric alcohols linear
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/20Organic compounds containing oxygen
    • C11D3/2003Alcohols; Phenols
    • C11D3/2065Polyhydric alcohols
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/20Organic compounds containing oxygen
    • C11D3/2068Ethers
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/26Organic compounds containing nitrogen
    • C11D3/28Heterocyclic compounds containing nitrogen in the ring
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/26Organic compounds containing nitrogen
    • C11D3/33Amino carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/37Polymers
    • C11D3/3703Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C11D3/3707Polyethers, e.g. polyalkyleneoxides
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/38Products with no well-defined composition, e.g. natural products
    • C11D3/386Preparations containing enzymes, e.g. protease or amylase
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/38Products with no well-defined composition, e.g. natural products
    • C11D3/386Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38618Protease or amylase in liquid compositions only
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/38Products with no well-defined composition, e.g. natural products
    • C11D3/386Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38627Preparations containing enzymes, e.g. protease or amylase containing lipase
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/38Products with no well-defined composition, e.g. natural products
    • C11D3/386Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38636Preparations containing enzymes, e.g. protease or amylase containing enzymes other than protease, amylase, lipase, cellulase, oxidase or reductase
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/38Products with no well-defined composition, e.g. natural products
    • C11D3/386Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38645Preparations containing enzymes, e.g. protease or amylase containing cellulase
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/02Anionic compounds
    • C11D1/12Sulfonic acids or sulfuric acid esters; Salts thereof
    • C11D1/123Sulfonic acids or sulfuric acid esters; Salts thereof derived from carboxylic acids, e.g. sulfosuccinates
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/02Anionic compounds
    • C11D1/12Sulfonic acids or sulfuric acid esters; Salts thereof
    • C11D1/14Sulfonic acids or sulfuric acid esters; Salts thereof derived from aliphatic hydrocarbons or mono-alcohols
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/02Anionic compounds
    • C11D1/12Sulfonic acids or sulfuric acid esters; Salts thereof
    • C11D1/29Sulfates of polyoxyalkylene ethers
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/02Anionic compounds
    • C11D1/34Derivatives of acids of phosphorus
    • C11D1/345Phosphates or phosphites
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/88Ampholytes; Electroneutral compounds
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/88Ampholytes; Electroneutral compounds
    • C11D1/90Betaines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Detergent Compositions (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)

Abstract

The invention discloses a medical foaming enzyme humectant and a preparation method thereof, wherein the medical foaming enzyme humectant comprises the following components in percentage by mass: 1 to 8 percent of anionic surfactant foaming agent, 2 to 10 percent of amphoteric surfactant foaming agent, 0.2 to 2.0 percent of compound biological enzyme, 3.0 to 10.0 percent of high molecular polymer humectant, 2.0 to 10.0 percent of solubilizer, 2.0 to 5.0 percent of compound corrosion inhibitor, 0.3 to 2.5 percent of foam stabilizer and the balance of water. The novel pollution-free environment-friendly medical foaming enzyme humectant provided by the invention adopts an acidic and chlorinated compound-free formula, is neutral, and has no corrosion to carbon steel, stainless steel and the like. The invention aims to provide an environment-friendly medical foaming enzyme humectant which is environment-friendly, convenient to use, obvious in effect and free of pollution.

Description

Medical foaming enzyme humectant and preparation method thereof
Technical Field
The invention relates to the technical field of novel medical foaming enzyme humectant compositions, in particular to a medical foaming enzyme humectant and a preparation method thereof.
Background
The existing moisturizers comprise a gel moisturizer and a foam moisturizer, and the action principle of the moisturizer is that pollutants on instruments and appliances are kept to have certain wettability by blocking air through gel or foam, so that the subsequent procedure is convenient to operate. The gel humectant liquid has certain viscosity, is inconvenient to use, and is not as good as the foam humectant can quickly cover the surface of an apparatus. Most of the current foam moisturizers are used for beating foam by means of efficient pressing of foaming pump heads, foam is broken and defoamed within two to three hours of foam duration, instruments subjected to operation in a hospital are generally subjected to centralized treatment, some intervals are 4 hours, especially in night operation, the instruments are cleaned in the next day, the cleaning intervals reach 12 hours or longer, and the effectiveness of existing products in the market is very difficult to meet the requirement of the practical phenomenon.
The moisture retention refers to a process of keeping the contaminants (including blood, tissue, protein, and the like) and part of the microorganisms attached to the surfaces of the medical instruments, instruments and articles moist and avoiding drying for the reason of centralized cleaning, so as to lay a good foundation for the next link of efficient and rapid thorough cleaning.
In the using process of the medical apparatus, due to continuous contact with a human body, a large amount of blood, fat, starch and other dirt are carried, a biomembrane tissue is attached, the conventional cleaning procedure is to be cleaned and treated regularly and intensively, various pollutants have serious erosion on the medical apparatus and the instrument in the period, and the cleaning of various pollutants after drying and curing wastes time and labor, so that the apparatus and the instrument are protected from being corroded and can be kept wet to a certain extent, and the subsequent work charging operation is easy, and a high-efficiency moisture-preserving product and a high-efficiency moisture-preserving method are needed to meet the requirement.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a medical foaming enzyme humectant and a preparation method thereof, aiming at solving the technical problems that the prior art can not have the effects of cleaning and long-time moisture preservation (the foam has long persistence and the defoaming time is more than 24 hours), and has no corrosion to carbon steel, stainless steel and other apparatuses and appliances.
In order to solve the problems, the invention discloses a medical foaming enzyme humectant which comprises the following components in percentage by mass: 1-8% of anionic surfactant foaming agent, 2-10% of amphoteric surfactant foaming agent, 0.2-2.0% of compound biological enzyme preparation, 3.0-10.0% of high molecular polymer humectant, 2.0-10.0% of solubilizer, 2.0-5.0% of compound corrosion inhibitor, 0.3-2.5% of foam stabilizer and the balance of water.
Preferably, the medical foaming enzyme humectant comprises the following components in percentage by mass: 3.0-6.0 percent of anionic surfactant foaming agent, 5.0-8.0 percent of amphoteric surfactant foaming agent, 1.0-1.5 percent of compound biological enzyme preparation, 5.0-8.0 percent of high molecular polymer humectant, 5.0-8.0 percent of solubilizer, 3.0-4.0 percent of compound corrosion inhibitor, 1.0-2.0 percent of foam stabilizer and the balance of water. Further preferably 4.0-5.0% of anionic surfactant foaming agent, 6.0-7.0% of amphoteric surfactant foaming agent, 1.2-1.4% of composite biological enzyme preparation, 6.0-7.0% of high molecular polymer humectant, 6.0-7.0% of solubilizer, 3.5-3.8% of composite corrosion inhibitor, 1.2-1.8% of foam stabilizer and the balance of water.
Preferably, the foaming agent is selected from a mixture of three to five of anionic surfactants and amphoteric surfactants, the mixing ratio therebetween is not limited, and when three are selected, the preferred mass ratio is equivalent or the preferred mass ratio therebetween is 3: 4.2: 4.8.
preferably, the high molecular polymer humectant is one selected from alpha-hydrogen-omega-hydroxyl (oxy-1, 2-ethanediyl) polymers.
Preferably, the complex bio-enzyme preparation is a mixture of two or more selected from the group consisting of protease, lipase, amylase, cellulase, pectinase, RNA polymerase, and hydrolase, and the mixing ratio of the two or more is not limited, preferably 4: 1: 1.4.
preferably, the solubilizer is selected from one of propylene glycol, ethanol, dipropylene glycol butyl ether or isopropanol.
Preferably, the corrosion inhibitor is one of imidazoline, amino acid and inorganic corrosion inhibitors, and is an environment-friendly chemical with good biodegradability.
Preferably, the foam stabilizer is one of polyether foam stabilizers, natural pectin foam stabilizers and protein foam stabilizers.
In order to solve the problems, the invention also discloses a preparation method of the novel medical foaming enzyme humectant, which comprises the steps of adding all or 50-60% of the water in the formula or the mass ratio of all the water in the formula, then sequentially adding an anionic surfactant, an amphoteric surfactant, a compound biological enzyme, a high-molecular polymer humectant, a solubilizer, a compound corrosion inhibitor and a foam stabilizer into water, supplementing the rest water, and continuously stirring until all the water is dissolved to obtain the medical foaming enzyme humectant.
The invention has the following beneficial effects:
the environment-friendly medical foaming enzyme humectant provided by the invention is prepared by compounding a composite biological enzyme preparation, an environment-friendly solvent and a surfactant, adopts a phosphorus-free formula, does not contain a fluorescent whitening agent, an acid and alkali, and a chlorine-containing organic matter, is environment-friendly, has a biodegradation rate of more than 90%, is non-toxic and harmless, and has an antistatic property; the moisture retention process has no corrosion and no damage to the instruments; the medical instrument has the characteristics of easy flushing and high-efficiency cleaning, and can decompose or soften blood stain, protein, mucopolysaccharide, carbohydrate, fat and other mixed pollutants on the inner surface and the outer surface of the surgical instrument in the moisturizing process, so that the moisturizing requirement and the cleaning effect are met, and the standard requirement of the domestic medical instrument pretreatment link is met; the product has good foaming effect of the conventional foam nozzle, and is easy to foam manually or mechanically. The process formula of the environment-friendly medical foaming enzyme humectant can be prepared at normal temperature, so that heat energy is saved; the performance is stable, the foaming power is good, and the cleaning function is achieved, so that mixed pollutants such as blood stain, fat and the like on surgical instruments can be kept in a closed environment for a long time and isolated from air, and the moisture is preserved in all directions.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.
Example 1
The embodiment provides a novel medical foaming enzyme humectant which comprises the following components in percentage by mass:
product name Mass percent% Product name Mass percent%
Anionic surface-active foaming agent 3.0 High molecular polymer humectant 6.0
Amphoteric surface-active foaming agents 8.0 Composite corrosion inhibitor 5.0
Composite biological enzyme preparation 0.5 Foam stabilizer 1.0
Solubilizer 4.0 RO pure water 72.5
Wherein the compound biological enzyme preparation is selected from more than two of protease, lipase, amylase, cellulase, pectinase, RNA polymerase and hydrolase. In the embodiment, protease, lipase, amylase and pectinase can be adopted, and the mass ratio is 6: 2: 1: 1; or protease, lipase, amylase and cellulase are adopted, and the mass ratio is 5: 2: 1.5: 1.5; or protease and lipase are adopted, and the mass ratio is 6: 4; or protease, lipase, amylase, pectinase and RNA polymerase are adopted, and the mass ratio is 5: 2: 1: 1: 1; or protease, lipase, amylase, cellulase, pectinase, RNA polymerase and hydrolase are adopted, and the mass ratio is 4: 1.5: 2: 0.5: 1: 0.75: 0.25, etc.
In this embodiment, the solubilizer may be propylene glycol, ethanol, butyl diglycol or isopropanol.
The humectant in this embodiment may be food-grade high molecular polymer, such as: glycerol, ethylene glycol, propylene glycol or polyethylene glycol.
The foaming agent in this embodiment is selected from any one of an anionic surfactant and an amphoteric surfactant or a mixture of three to five of the anionic surfactant and the amphoteric surfactant, and the mass ratio of the foaming agent to the amphoteric surfactant is not limited, for example: sodium alpha-olefin sulfonate, secondary alkyl sodium sulfonate, ethoxylated alkyl sodium sulfate, dodecyl betaine, cocamidopropyl amine oxide, disodium lauryl sulfosuccinate, potassium monododecyl phosphate.
Wherein, the polymer humectant in this embodiment is selected from one of the polymers of α -hydro- ω -hydroxy (oxy-1, 2-ethanediyl), such as: polyethylene glycol 200, polyethylene glycol 400, polyethylene glycol 600 or polyethylene glycol 2000.
The corrosion inhibitor in the embodiment is one of imidazoline, amino acid and inorganic corrosion inhibitors, and is an environment-friendly chemical with good biodegradability.
The foam stabilizer in this embodiment is one selected from a polyether foam stabilizer, a natural pectin foam stabilizer, and a protein foam stabilizer.
The preparation method of the novel medical foaming enzyme humectant comprises the following steps:
firstly, 50% of the water amount of the formula is added into a container, an anionic surfactant, an amphoteric surfactant, a compound bio-enzyme preparation, a polymer humectant, a solubilizer, a corrosion inhibitor and a foam stabilizer are sequentially added, the rest water is replenished, and the mixture is continuously stirred until the mixture is completely dissolved, so that the water-soluble organic silicon gel is obtained.
The invention discloses a novel medical foaming enzyme humectant foam duration test method which comprises the following steps:
1. duration of foam
(1) Placing a surgical instrument in a square tray, spraying medical foaming enzyme humectant with a common foam nozzle, and directly spraying the medical foaming enzyme humectant in the square tray, wherein the instrument is covered by spraying foam for 50 times.
(2) Placing two round carbon steel sheets in the same square tray, spraying medical foaming enzyme humectant with common foam nozzle, and directly spraying for 50 times.
(3) After the bubbles are sprayed on each square tray for 50 times, a stopwatch is pressed to start timing, the first recording time is that the bubbles are exposed out of the surgical instrument, and the final recording time is that the bubbles are completely broken;
(4) and after the time reaches 5 hours, taking out the round carbon steel sheet by using tweezers, directly washing the round carbon steel sheet by using soft water, drying the round carbon steel sheet in an oven at the temperature of 45 ℃ for 20 minutes, drying water stains, and observing and measuring the appearance and the quality of the round carbon steel sheet.
And (3) test results:
1. the round carbon steel sheet has no appearance change, no stain, no corrosion and no quality loss.
2. The foam lasts for 12 hours at 1 st; the 2 nd time for complete disappearance of foam was 48 hours.
And (3) test results: the novel medical foaming enzyme humectant disclosed by the invention has long foam duration and does not corrode carbon steel and stainless steel instruments.
Example 2
The embodiment provides a novel medical foaming enzyme humectant which comprises the following components in percentage by mass:
product name Mass percent% Product name Mass percent%
Anionic surface-active foaming agent 5.0 High molecular polymer humectant 5.0
Amphoteric surface-active foaming agents 6.0 Composite corrosion inhibitor 2.5
Composite biological enzyme preparation 1.0 Foam stabilizer 2.0
Solubilizer 8.0 RO pure water 70.5
Wherein the compound biological enzyme preparation is selected from more than two of protease, lipase, amylase, cellulase, pectinase, RNA polymerase and hydrolase. Proteases, lipases, amylases, and pectinases may be used in this example; or protease, lipase, amylase and cellulase; or protease and lipase; or protease, lipase, amylase, pectinase and RNA polymerase; or a combination of protease, lipase, amylase, cellulase, pectinase, RNA polymerase, hydrolase, etc.
In this embodiment, the solubilizer may be propylene glycol, ethanol, butyl diglycol or isopropanol.
The humectant in this embodiment may be a food-grade polymer.
Wherein, the foaming agent in the embodiment is selected from three to five of anionic surfactant and amphoteric surfactant.
In this embodiment, the polymer humectant is selected from one of α -hydro- ω -hydroxy (oxy-1, 2-ethanediyl) polymers.
The corrosion inhibitor in the embodiment is one of imidazoline, amino acid and inorganic corrosion inhibitors, and is an environment-friendly chemical with good biodegradability.
The foam stabilizer in the embodiment is a compound of amphoteric surface active and modified polyether.
The preparation method of the novel medical foaming enzyme humectant comprises the following steps:
firstly, 55% of the water amount of the formula is added into a container, an anionic surfactant, an amphoteric surfactant, a compound bio-enzyme preparation, a polymer humectant, a solubilizer, a corrosion inhibitor and a foam stabilizer are sequentially added, the rest water is replenished, and the mixture is continuously stirred until the mixture is completely dissolved, so that the water-soluble organic silicon gel is obtained.
The rest is the same as that described in embodiment 1, and will not be described herein.
Example 3
The embodiment provides a novel medical foaming enzyme humectant which comprises the following components in percentage by mass:
product name Mass percent% Product name Mass percent%
Anionic surface-active foaming agent 2.0 High molecular polymer humectant 8.0
Amphoteric surface-active foaming agents 4.5 Composite corrosion inhibitor 2.0
Composite biological enzyme preparation 1.0 Foam stabilizer 2.5
Solubilizer 7.5 RO pure water 72.5
Wherein the compound biological enzyme preparation is selected from more than two of protease, lipase, amylase, cellulase, pectinase, RNA polymerase and hydrolase. Proteases, lipases, amylases, and pectinases may be used in this example; or protease, lipase, amylase and cellulase; or protease and lipase; or protease, lipase, amylase, pectinase and RNA polymerase; or a combination of protease, lipase, amylase, cellulase, pectinase, RNA polymerase, hydrolase, etc.
In this embodiment, the solubilizer may be propylene glycol, ethanol, butyl diglycol or isopropanol.
The humectant in this embodiment may be a food-grade polymer.
Wherein, the foaming agent in the embodiment is selected from three to five of anionic surfactant and amphoteric surfactant.
In this embodiment, the polymer humectant is selected from one of α -hydro- ω -hydroxy (oxy-1, 2-ethanediyl) polymers.
The corrosion inhibitor in the embodiment is one of amino acids, and is an environment-friendly chemical with good biodegradability.
The foam stabilizer in the embodiment is a compound of amphoteric surface active and modified polyether.
The preparation method of the novel medical foaming enzyme humectant comprises the following steps:
firstly, 60% of the water amount of the formula is added into a container, an anionic surfactant, an amphoteric surfactant, a compound bio-enzyme preparation, a polymer humectant, a solubilizer, a corrosion inhibitor and a foam stabilizer are sequentially added, the rest water is replenished, and the mixture is continuously stirred until the mixture is completely dissolved, so that the water-soluble organic silicon gel is obtained.
The rest is the same as that described in embodiment 1, and will not be described herein.
Example 4
The embodiment provides a novel medical foaming enzyme humectant which comprises the following components in percentage by mass:
product name Mass percent% Product name Mass percent%
Anionic surface-active foaming agent 1.0 High molecular polymer humectant 10.0
Amphoteric surface-active foaming agents 2.0 Composite corrosion inhibitor 3.0
Composite biological enzyme preparation 0.2 Foam stabilizer 0.3
Solubilizer 2.0 RO pure water 81.5
The selection of the types of reagents is the same as that in example 1, and the preparation method is also the same as that in example 1, and the details are not repeated here. And (3) test results: the medical foaming enzyme humectant disclosed by the embodiment has long foam duration and does not corrode carbon steel and stainless steel instruments.
Example 5
The embodiment provides a novel medical foaming enzyme humectant which comprises the following components in percentage by mass:
product name Mass percent% Product name Mass percent%
Anionic surface-active foaming agent 8.0 High molecular polymer humectant 7.0
Amphoteric surface-active foaming agents 10.0 Composite corrosion inhibitor 4.0
Composite biological enzyme preparation 2.0 Foam stabilizer 1.2
Solubilizer 10.0 RO pure water 57.8
The selection of the types of reagents is the same as that in example 1, and the preparation method is also the same as that in example 1, and the details are not repeated here. The medical foaming enzyme humectant disclosed by the embodiment has long foam duration and does not corrode carbon steel and stainless steel instruments.
Example 6
The embodiment provides a novel medical foaming enzyme humectant which comprises the following components in percentage by mass:
product name Mass percent% Product name Mass percent%
Anionic surface-active foaming agent 4.0 High molecular polymer humectant 3.0
Amphoteric surface-active foaming agents 5.0 Composite corrosion inhibitor 3.5
Composite biological enzyme preparation 1.2 Foam stabilizer 1.5
Solubilizer 5.0 RO pure water 76.8
The selection of the types of reagents is the same as that in example 1, and the preparation method is also the same as that in example 1, and the details are not repeated here. The medical foaming enzyme humectant disclosed by the embodiment has long foam duration and does not corrode carbon steel and stainless steel instruments.
Example 7
The embodiment provides a novel medical foaming enzyme humectant which comprises the following components in percentage by mass:
product name Mass percent% Product name Mass percent%
Anionic surface-active foaming agent 6.0 High molecular polymer humectant 4.0
Amphoteric surface-active foaming agents 7.0 Composite corrosion inhibitor 3.8
Composite biological enzyme preparation 1.5 Foam stabilizer 1.8
Solubilizer 6.0 RO pure water 69.9
The selection of the types of reagents is the same as that in example 1, and the preparation method is also the same as that in example 1, and the details are not repeated here. The medical foaming enzyme humectant disclosed by the embodiment has long foam duration and does not corrode carbon steel and stainless steel instruments.
The above is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and various modifications and changes will occur to those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (3)

1. The medical foaming enzyme humectant is characterized by comprising the following components in percentage by mass: 1-8% of anionic surfactant foaming agent, 2-10% of amphoteric surfactant foaming agent, 0.2-2.0% of compound biological enzyme preparation, 3.0-10.0% of high molecular polymer humectant, 2.0-10.0% of solubilizer, 2.0-5.0% of compound corrosion inhibitor, 0.3-2.5% of foam stabilizer and the balance of water;
the foaming agent is selected from a mixture formed by three to five of anionic surfactant and amphoteric surfactant;
the compound biological enzyme preparation is a mixture formed by more than two of protease, lipase, amylase, cellulase, pectinase, RNA polymerase and hydrolase; the composite biological enzyme preparation adopts protease, lipase, amylase and pectinase, and the mass ratio is 6: 2: 1: 1; or protease, lipase, amylase and cellulase are adopted, and the mass ratio is 5: 2: 1.5: 1.5; or protease, lipase, amylase, pectinase and RNA polymerase are adopted, and the mass ratio is 5: 2: 1: 1: 1; or protease, lipase, amylase, cellulase, pectinase, RNA polymerase and hydrolase are adopted, and the mass ratio is 4: 1.5: 2: 0.5: 1: 0.75: 0.25;
the high molecular polymer humectant is one selected from alpha-hydrogen-omega-hydroxyl (oxygen-1, 2-ethanediyl) polymers;
the solubilizer is selected from one of propylene glycol, ethanol, dipropylene glycol butyl ether or isopropanol;
the corrosion inhibitor is one of imidazoline, amino acid and inorganic corrosion inhibitors;
the foam stabilizer is a polyether foam stabilizer.
2. The medical foaming enzyme humectant according to the claim 1, characterized in that, by mass percentage, it comprises the following components: 3.0-6.0 percent of anionic surfactant foaming agent, 5.0-8.0 percent of amphoteric surfactant foaming agent, 1.0-1.5 percent of compound biological enzyme preparation, 5.0-8.0 percent of high molecular polymer humectant, 5.0-8.0 percent of solubilizer, 3.0-4.0 percent of compound corrosion inhibitor, 1.0-2.0 percent of foam stabilizer and the balance of water.
3. The method for preparing the medical foaming enzyme moisturizer as claimed in any one of claims 1 to 2, which is characterized in that: adding 50-60% of the total amount of the formula water or the mass ratio, then sequentially adding an anionic surfactant, an amphoteric surfactant, a compound biological enzyme preparation, a polymer humectant, a solubilizer, a corrosion inhibitor and a foam stabilizer into the water, supplementing the rest of the water, and continuously stirring until the components are completely and uniformly dissolved to obtain the medical foaming enzyme humectant.
CN201810182714.7A 2018-03-06 2018-03-06 Medical foaming enzyme humectant and preparation method thereof Active CN108410594B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810182714.7A CN108410594B (en) 2018-03-06 2018-03-06 Medical foaming enzyme humectant and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810182714.7A CN108410594B (en) 2018-03-06 2018-03-06 Medical foaming enzyme humectant and preparation method thereof

Publications (2)

Publication Number Publication Date
CN108410594A CN108410594A (en) 2018-08-17
CN108410594B true CN108410594B (en) 2020-12-08

Family

ID=63129802

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810182714.7A Active CN108410594B (en) 2018-03-06 2018-03-06 Medical foaming enzyme humectant and preparation method thereof

Country Status (1)

Country Link
CN (1) CN108410594B (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5998342A (en) * 1998-08-26 1999-12-07 Cottrell International, Llc Foaming enzyme spray cleaning composition and method of delivery
US6235692B1 (en) * 1998-08-26 2001-05-22 Cottrell International, Llc Foaming enzyme spray cleaning composition and method of delivery
EP0994178B1 (en) * 1998-10-15 2003-02-05 B. Braun Medical AG Cleaning compositions and their use
DE102004035881A1 (en) * 2004-07-23 2006-02-16 Merz Pharma Gmbh & Co. Kgaa Composition, useful for machine cleaning and disinfecting medical instrument of composite materials (e.g. flexible endoscope), comprises active substance combination of alkyldimethylammonium and protease, surfactant, water and additives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070259801A1 (en) * 2006-03-31 2007-11-08 Szu-Min Lin Composition for a foam pretreatment for medical instruments
CN102294056B (en) * 2011-09-02 2013-12-04 山东新华医疗器械股份有限公司 Surgical instrument moisturizing agent and preparation method thereof
CN103087834A (en) * 2011-11-04 2013-05-08 上海利康消毒高科技有限公司 Pre-cleaning and moisturizing composition of medical apparatuses and method of preparing disinfectant by using same
CN104073323B (en) * 2013-12-05 2016-08-31 老肯医疗科技股份有限公司 A kind of lubricant being applicable to medicine equipment and preparation method
CN104073367A (en) * 2013-12-05 2014-10-01 成都老肯科技股份有限公司 Multienzyme cleaning solution suitable for machine-washable medical devices and preparation method thereof
CN105154251A (en) * 2015-10-16 2015-12-16 青岛海之星生物科技有限公司 Foam cleaning composition
CN106544164A (en) * 2016-11-02 2017-03-29 广州润虹医药科技有限公司 A kind of high-effective low foam antibacterial type multienzyme cleaning agent and its preparation technology

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5998342A (en) * 1998-08-26 1999-12-07 Cottrell International, Llc Foaming enzyme spray cleaning composition and method of delivery
US6235692B1 (en) * 1998-08-26 2001-05-22 Cottrell International, Llc Foaming enzyme spray cleaning composition and method of delivery
EP0994178B1 (en) * 1998-10-15 2003-02-05 B. Braun Medical AG Cleaning compositions and their use
DE102004035881A1 (en) * 2004-07-23 2006-02-16 Merz Pharma Gmbh & Co. Kgaa Composition, useful for machine cleaning and disinfecting medical instrument of composite materials (e.g. flexible endoscope), comprises active substance combination of alkyldimethylammonium and protease, surfactant, water and additives

Also Published As

Publication number Publication date
CN108410594A (en) 2018-08-17

Similar Documents

Publication Publication Date Title
CN102071113B (en) Condensed multi-enzyme medical cleaning agent
CN102492574B (en) Tableware detergent containing N-acylglutamate
DE69425142D1 (en) THICKENED CLEANER FOR HARD SURFACES
CN105623918A (en) Low-foam multienzyme cleaning agent
ES2776371T3 (en) Composition containing peroxide and peracetic acid and spore removal procedure
CN106047505A (en) Natural-formulation multi-effect cleaning composition and application thereof
CN103865663A (en) Medical multi-enzyme cleaning agent and preparation method thereof
CN101368139A (en) Laboratory glassware detergent
CN101880606A (en) Liquid cleaning composition with biomembrane removing function
CN111394197A (en) Complex enzyme cleaning agent for medical instrument antibiosis and antitoxic
CN104480482A (en) Special cleaning solution for slightly alkaline chemical equipment
CN105779166A (en) Preparation method of low-foaming multienzyme cleaning agent for medical apparatus and instruments
CN104450264A (en) Special cleaning agent for chemical equipment
CN110003991A (en) A kind of medical multienzyme cleaning cream and preparation method thereof removing the heavy scale
CN106190603A (en) A kind of medical apparatus and instruments multienzyme cleaning agent containing natural bacteriostatic agent
AU719542B2 (en) A composition for cleaning surfaces
CN112358916A (en) Multienzyme cleaning solution and preparation method thereof
CN108410594B (en) Medical foaming enzyme humectant and preparation method thereof
GB2482164A (en) Cleaning composition
CN102294056B (en) Surgical instrument moisturizing agent and preparation method thereof
CN106456667B (en) Low foaming multienzyme detergent
CN104498970A (en) Chemical equipment detergent
CN108865494A (en) A kind of highly-efficient glass cleaning agent and preparation method thereof
CN104450266A (en) Environment-friendly decontaminant for chemical equipment
CN103666824B (en) A kind of Fabric degreaser and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant