CN108410594A - Medical foam enzyme moisturizer and preparation method thereof - Google Patents

Medical foam enzyme moisturizer and preparation method thereof Download PDF

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Publication number
CN108410594A
CN108410594A CN201810182714.7A CN201810182714A CN108410594A CN 108410594 A CN108410594 A CN 108410594A CN 201810182714 A CN201810182714 A CN 201810182714A CN 108410594 A CN108410594 A CN 108410594A
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Prior art keywords
moisturizer
enzyme
foam
medical foam
foaming agent
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CN201810182714.7A
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CN108410594B (en
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周祺
伍川
崔丽平
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Beijing Jiashili Technology Co Ltd
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Beijing Jiashili Technology Co Ltd
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    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
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    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
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    • C11D3/38Products with no well-defined composition, e.g. natural products
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Abstract

The invention discloses a kind of medical foam enzyme moisturizer and preparation method thereof, the medical foam enzyme moisturizer by mass percentage, including following component:Anion surfactant foaming agent 1%~8%, amphoteric surfactant foaming agent 2%~10%, compound biological enzyme system 0.2%~2.0%, high molecular polymer moisturizer 3.0%~10.0%, solubilizer 2.0%~10.0%, composite corrosion inhibitor 2.0%~5.0% and foam stabilizer 0.3%~2.5%, surplus are water.Novel pollution-free environment-friendly type medical foam enzyme moisturizer provided by the invention uses no acidic and chlorinated compound, corrosion-free to carbon steel, stainless steel etc. for neutral formula.It is an object of the invention to provide a kind of free of contamination environment-friendly type medical foam enzyme moisturizer environmentally protective, easy to use, with obvious effects.

Description

Medical foam enzyme moisturizer and preparation method thereof
Technical field
The present invention relates to new medical foam enzyme humectant composition technical fields more particularly to a kind of medical foam enzyme to protect Humectant and preparation method thereof.
Background technology
It is to obstruct air by gel or foam that current moisturizer, which has gel moisturizer, foam moisturizer, action principle, Come keep instrument, the pollutant on utensil has certain wettability, easily operated convenient for latter procedure.Gel moisturizer liquid There is certain toughness, in use of time inconvenience, is not so good as foam moisturizer energy rapid Cover equipment surfaces.And current foam is protected Humectant major part is intended to get foam by means of efficiently pressing foaming pump head, and foam duration is usually two or three Hour lather collapse and then defoaming, and the instrument that present hospitals are performed the operation generally concentrates processing, some interval times are 4 small When, when especially night performs the operation, instrument is intended to clean at second day, and the Clean after every time reaches 12 hours or longer Time, the very difficult demand for reaching this real phenomenon of effectiveness of existing products in markets.
Moisturizing refers to dirt (including blood, tissue, the albumen in order to avoid medical instrument, utensil and article surface adhere to Matter etc.) and part microorganism have little time to clean, or the reason of in order to concentrate cleaning, make medical instrument, utensil and article surface The dirt (including blood, tissue, protein etc.) of attachment and part microorganism keep moistening to avoid drying up, and are next efficiently fast The thorough link of cleaning of speed lays the process of good basis.
Medical instrument carries a large amount of blood in use because constantly being contacted with human body, the dirts such as fat and starch, It is accompanied with biomembrane tissue, conventional cleaning procedure is all periodically to concentrate cleaning treatment, and various pollutants are to doctor in the meantime It is serious to treat instrument, utensil aggressivity, cleaned after the dry solidification of various pollutants it is time-consuming and laborious, in this way in order to protect instrument, utensil One of work fills operation not contaminated erosion can allow it that certain moistening is kept to be easy to again after, it is necessary to a kind of product of efficient moisture-retention with Method meets this demand.
Invention content
For problems of the prior art, the present invention provides a kind of medical foam enzyme moisturizer and its preparation sides Method, to solve, the prior art can not can clean and (foam duration is long, and foam time is small up to 24 the effect of long-time moisturizing When more than), and to the instruments such as carbon steel, stainless steel, the free from corrosion technical problem of utensil, the present invention when in use, with one As foam nozzle can achieve the effect that foam Pressing pump, use and operate convenient for people, it is time saving and energy saving.
To solve the above-mentioned problems, the invention discloses a kind of medical foam enzyme moisturizer, by mass percentage, including Following component:Anion surfactant foaming agent 1%~8%, amphoteric surfactant foaming agent 2%~10%, compound life It is object enzyme preparation 0.2%~2.0%, high molecular polymer moisturizer 3.0%~10.0%, solubilizer 2.0%~10.0%, compound Corrosion inhibiter 2.0%~5.0% and foam stabilizer 0.3%~2.5%, surplus are water.
Preferably, the medical foam enzyme moisturizer, by mass percentage, including following component:Anionic surface Activating agent foaming agent 3.0%~6.0%, amphoteric surfactant foaming agent 5.0%~8.0%, composite biological enzyme preparation 1.0% ~1.5%, high molecular polymer moisturizer 5.0%~8.0%, solubilizer 5.0%~8.0%, composite corrosion inhibitor 3.0%~ 4.0% and foam stabilizer 1.0%~2.0%, surplus be water.Further preferably anion surfactant foaming agent 4.0%~ 5.0%, amphoteric surfactant foaming agent 6.0%~7.0%, composite biological enzyme preparation 1.2%~1.4%, high molecular polymerization Object moisturizer 6.0%~7.0%, solubilizer 6.0%~7.0%, composite corrosion inhibitor 3.5%~3.8% and foam stabilizer 1.2%~ 1.8%, surplus is water.
Preferably, three to five kind formation of the foaming agent in anion surfactant, amphoteric surfactant Mixture, mutual mixed proportion there is no limit, when select three kinds when, preferred mass ratio quite or preferably between each other Mass ratio be 3:4.2:4.8.
Preferably, the high molecular polymer moisturizer is selected from the polymer of α-hydrogen-ω-hydroxyl (oxygen -1,2- second diyl) In one kind.
Preferably, the composite biological enzyme preparation is selected from protease, lipase, amylase, cellulase, pectase, RNA The mixture of two or more formation in polymerase, hydrolase, there is no limit preferably 4 for mutual mixed proportion:1:1.4.
Preferably, the one kind of the solubilizer in propylene glycol, ethyl alcohol, dipropylene or isopropanol.
Preferably, the corrosion inhibiter is one kind in imidazoline, amino acid, inorganic type corrosion inhibiter, and biological degradability is good , environmentally friendly chemicals.
Preferably, the foam stabilizer is one in polyethers foam stabilizer, natural pectin class foam stabilizer, protide foam stabilizer Kind.
To solve the above-mentioned problems, the invention also discloses a kind of preparation method of new medical foam enzyme moisturizer, add Enter to be formulated water entirely or entirely or mass ratio 50%~60%, anion surface active is then sequentially added into water Agent, amphoteric surfactant, compound biological enzyme system, high molecular polymer moisturizer, solubilizer, composite corrosion inhibitor and foam stabilizer, Remaining water is supplied, is stirred continuously until that all dissolving is to get medical foam enzyme moisturizer.
The present invention has the advantages that:
Environment-friendly type medical foam enzyme moisturizer provided by the invention is by composite biological enzyme preparation, environmentally friendly solvent and surface-active Agent compounds, using without phosphorus formula, without fluorescent whitening agent, without soda acid, without chlorinated organics, it is environmentally protective, it is biodegradable Rate is nontoxic more than 90%, has both antistatic property;Moisturizing process is corrosion-free to instrument not damaged;It has both and easily rinses, efficiently The characteristics of cleaning, can make bloodstain, protein, glutinous polysaccharide, carbohydrate, the fat of surgical instrument inner and outer surfaces during moisturizing The mixed pollutants such as fat decompose or softening, the requirement for reaching moisturizing have both clean utility, meet Chinese Medical Device Manufacturers pretreatment ring The standard requirement of section;The product usual foam nozzle foaming effect is good, is easy to craft or Foaming by the machine operation.The environment-friendly type is medical The technical recipe of foam enzyme moisturizer can room temperature configuration, saving heat energy;Performance is stablized, and foaming power has cleaning action concurrently well, makes hand The mixed pollutants such as bloodstain and fat on art instrument are in closed environment for a long time, with air exclusion, comprehensive moisturizing.
Specific implementation mode
It in order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below will be in the embodiment of the present invention Technical solution be clearly and completely described, it is clear that described embodiment be the present invention a part of the embodiment, without It is whole embodiment.Based on the embodiments of the present invention, those of ordinary skill in the art are not making creative work Under the premise of the every other embodiment that is obtained, shall fall within the protection scope of the present invention.
Embodiment 1
A kind of new medical foam enzyme moisturizer is present embodiments provided, by mass percentage, including following component:
Name of product Mass percent % Name of product Mass percent %
Anion surface active foaming agent 3.0 High molecular polymer moisturizer 6.0
Amophoteric surface active foaming agent 8.0 Composite corrosion inhibitor 5.0
Composite biological enzyme preparation 0.5 Foam stabilizer 1.0
Solubilizer 4.0 RO pure water 72.5
Wherein, it is poly- to be selected from protease, lipase, amylase, cellulase, pectase, RNA for the composite biological enzyme preparation Two kinds or more in synthase, hydrolase.Protease, lipase, amylase and pectase, mass ratio can be used in the present embodiment It is 6:2:1:1;Or using protease, lipase, amylase and cellulase, mass ratio 5:2:1.5:1.5;Or it adopts With protease and lipase, mass ratio 6:4;Or using protease, lipase, amylase, pectase and RNA polymerizations Enzyme, mass ratio 5:2:1:1:1;Or using protease, lipase, amylase, cellulase, pectase, RNA polymerizations Enzyme, hydrolase, mass ratio 4:1.5:2:0.5:1:0.75:The combining forms such as 0.25.
Wherein, propylene glycol, ethyl alcohol, butyl or isopropanol can be used in the solubilizer in the present embodiment.
Wherein, food medicine grade high molecular polymer can be used, such as in the moisturizer in the present embodiment:Glycerine, ethylene glycol, third Glycol or polyethylene glycol.
Wherein, the foaming agent in the present embodiment in anion surfactant, amphoteric surfactant any one Or in which three to five kinds of equal formation mixtures, there is no limit such as mutual quality proportioning:Alpha-olefin sodium sulfonate, secondary alkyl sulphur Sour sodium, ethoxylated alkyl sulfate, empgen BB, cocamidopropyl propyl amide amine oxide, lauryl sulfosuccinate list Ester disodium, Monododecylphosphate potassium.
Wherein, high molecular polymer moisturizer is selected from the poly- of α-hydrogen-ω-hydroxyl (oxygen -1,2- second diyl) in the present embodiment One kind in object is closed, such as:Polyethylene glycol 200, polyethylene glycol 400, Macrogol 600 or polyethylene glycol 2000.
Wherein, the corrosion inhibiter in the present embodiment is one kind in imidazoline, amino acid, inorganic type corrosion inhibiter, biology drop Good, the environmentally friendly chemicals of solution property.
Wherein, the foam stabilizer in the present embodiment is selected from polyethers foam stabilizer, natural pectin class foam stabilizer, protide foam stabilizer In one kind.
The preparation method of the present embodiment new medical foam enzyme moisturizer is:
First in container be added formula water 50%, sequentially add anion surfactant, amphoteric surfactant, Compound biological enzyme system, polymeric moisturizers, solubilizer, corrosion inhibiter, foam stabilizer supply remaining water, are stirred continuously until whole Dissolving to get.
New medical foam enzyme moisturizer foam duration test method of the present invention:
1. foam duration
(1) leader's art instrument is put in rectangular pallet, is sprayed medical foam enzyme moisturizer with regular-type foam nozzle, is directly sprayed In rectangular pallet, spray 50 covering instruments of bubble.
(2) same rectangular pallet is taken, two pieces of round carbon steel coupons is placed in wherein, sprays medical foam enzyme with regular-type foam nozzle Moisturizer is sprayed directly on in rectangular pallet, spray bubble 50 times.
(3) per rectangular pallet, spray is steeped up to after 50 times, is pressed stopwatch and is started timing, it is the first record that surgical instrument, which exposes foam, Time, foam completely it is broken come until be end record time eventually;
(4) timing is taken out round carbon steel coupon with tweezers, is directly rinsed with soft water, dry 20 points in 45 DEG C of baking ovens up to after 5 hours The appearance and quality of round carbon steel coupon are observed and measured to clock water stain drying.
Test result:
1. round carbon steel coupon appearance is without becoming outer, the corrosion-free phenomenon of no stain spot, mass loss.
2. the 1st time of foam duration is 12 hours;Foam the 2nd time of elimination completely is 48 hours.
Test result:New medical foam enzyme moisturizer foam duration of the present invention is long, to carbon steel, stainless steel instruments without Corrosion.
Embodiment 2
A kind of new medical foam enzyme moisturizer is present embodiments provided, by mass percentage, including following component:
Name of product Mass percent % Name of product Mass percent %
Anion surface active foaming agent 5.0 High molecular polymer moisturizer 5.0
Amophoteric surface active foaming agent 6.0 Composite corrosion inhibitor 2.5
Composite biological enzyme preparation 1.0 Foam stabilizer 2.0
Solubilizer 8.0 RO pure water 70.5
Wherein, composite biological enzyme preparation is selected from protease, lipase, amylase, cellulase, pectase, RNA polymerizations Two kinds or more in enzyme, hydrolase.Protease, lipase, amylase and pectase can be used in the present embodiment;Or use egg White enzyme, lipase, amylase and cellulase;Or use protease and lipase;Or using protease, lipase, shallow lake Powder enzyme, pectase and RNA polymerase;Or using protease, lipase, amylase, cellulase, pectase, RNA polymerizations The combining forms such as enzyme, hydrolase.
Wherein, propylene glycol, ethyl alcohol, butyl or isopropanol can be used in the solubilizer in the present embodiment.
Wherein, food medicine grade high molecular polymer can be used in the moisturizer in the present embodiment.
Wherein, the foaming agent in the present embodiment in anion surfactant, amphoteric surfactant three to five Kind etc..
Wherein, high molecular polymer moisturizer is selected from the poly- of α-hydrogen-ω-hydroxyl (oxygen -1,2- second diyl) in the present embodiment Close one kind in object.
Wherein, the corrosion inhibiter in the present embodiment is one kind in imidazoline, amino acid, inorganic type corrosion inhibiter, biology drop Good, the environmentally friendly chemicals of solution property.
Wherein, the foam stabilizer in the present embodiment is amophoteric surface active and modified polyether class compound.
The preparation method of the present embodiment new medical foam enzyme moisturizer is:
First in container be added formula water 55%, sequentially add anion surfactant, amphoteric surfactant, Compound biological enzyme system, polymeric moisturizers, solubilizer, corrosion inhibiter, foam stabilizer supply remaining water, are stirred continuously until whole Dissolving to get.
Other with it is consistent described in embodiment 1, details are not described herein.
Embodiment 3
A kind of new medical foam enzyme moisturizer is present embodiments provided, by mass percentage, including following component:
Name of product Mass percent % Name of product Mass percent %
Anion surface active foaming agent 2.0 High molecular polymer moisturizer 8.0
Amophoteric surface active foaming agent 4.5 Composite corrosion inhibitor 2.0
Composite biological enzyme preparation 1.0 Foam stabilizer 2.5
Solubilizer 7.5 RO pure water 72.5
Wherein, composite biological enzyme preparation is selected from protease, lipase, amylase, cellulase, pectase, RNA polymerizations Two kinds or more in enzyme, hydrolase.Protease, lipase, amylase and pectase can be used in the present embodiment;Or use egg White enzyme, lipase, amylase and cellulase;Or use protease and lipase;Or using protease, lipase, shallow lake Powder enzyme, pectase and RNA polymerase;Or using protease, lipase, amylase, cellulase, pectase, RNA polymerizations The combining forms such as enzyme, hydrolase.
Wherein, propylene glycol, ethyl alcohol, butyl or isopropanol can be used in the solubilizer in the present embodiment.
Wherein, food medicine grade high molecular polymer can be used in the moisturizer in the present embodiment.
Wherein, the foaming agent in the present embodiment in anion surfactant, amphoteric surfactant three to five Kind etc..
Wherein, high molecular polymer moisturizer is selected from the poly- of α-hydrogen-ω-hydroxyl (oxygen -1,2- second diyl) in the present embodiment Close one kind in object.
Wherein, the corrosion inhibiter in the present embodiment is one kind in amino acid, and biological degradability is good, environmentally friendly chemistry Product.
Wherein, the foam stabilizer in the present embodiment is amophoteric surface active and modified polyether class compound.
The preparation method of the present embodiment new medical foam enzyme moisturizer is:
First in container be added formula water 60%, sequentially add anion surfactant, amphoteric surfactant, Compound biological enzyme system, polymeric moisturizers, solubilizer, corrosion inhibiter, foam stabilizer supply remaining water, are stirred continuously until whole Dissolving to get.
Other with it is consistent described in embodiment 1, details are not described herein.
Embodiment 4
A kind of new medical foam enzyme moisturizer is present embodiments provided, by mass percentage, including following component:
Name of product Mass percent % Name of product Mass percent %
Anion surface active foaming agent 1.0 High molecular polymer moisturizer 10.0
Amophoteric surface active foaming agent 2.0 Composite corrosion inhibitor 3.0
Composite biological enzyme preparation 0.2 Foam stabilizer 0.3
Solubilizer 2.0 RO pure water 81.5
Reagent type selection is same as Example 1, and preparation method is also same as Example 1, and details are not described herein.Experiment knot Fruit:The medical foam enzyme moisturizer foam duration of the present embodiment is long, corrosion-free to carbon steel, stainless steel instruments.
Embodiment 5
A kind of new medical foam enzyme moisturizer is present embodiments provided, by mass percentage, including following component:
Name of product Mass percent % Name of product Mass percent %
Anion surface active foaming agent 8.0 High molecular polymer moisturizer 7.0
Amophoteric surface active foaming agent 10.0 Composite corrosion inhibitor 4.0
Composite biological enzyme preparation 2.0 Foam stabilizer 1.2
Solubilizer 10.0 RO pure water 57.8
Reagent type selection is same as Example 1, and preparation method is also same as Example 1, and details are not described herein.This implementation The medical foam enzyme moisturizer foam duration of example is long, corrosion-free to carbon steel, stainless steel instruments.
Embodiment 6
A kind of new medical foam enzyme moisturizer is present embodiments provided, by mass percentage, including following component:
Name of product Mass percent % Name of product Mass percent %
Anion surface active foaming agent 4.0 High molecular polymer moisturizer 3.0
Amophoteric surface active foaming agent 5.0 Composite corrosion inhibitor 3.5
Composite biological enzyme preparation 1.2 Foam stabilizer 1.5
Solubilizer 5.0 RO pure water 76.8
Reagent type selection is same as Example 1, and preparation method is also same as Example 1, and details are not described herein.This implementation The medical foam enzyme moisturizer foam duration of example is long, corrosion-free to carbon steel, stainless steel instruments.
Embodiment 7
A kind of new medical foam enzyme moisturizer is present embodiments provided, by mass percentage, including following component:
Name of product Mass percent % Name of product Mass percent %
Anion surface active foaming agent 6.0 High molecular polymer moisturizer 4.0
Amophoteric surface active foaming agent 7.0 Composite corrosion inhibitor 3.8
Composite biological enzyme preparation 1.5 Foam stabilizer 1.8
Solubilizer 6.0 RO pure water 69.9
Reagent type selection is same as Example 1, and preparation method is also same as Example 1, and details are not described herein.This implementation The medical foam enzyme moisturizer foam duration of example is long, corrosion-free to carbon steel, stainless steel instruments.
It these are only the preferred embodiment of the present invention, be not intended to restrict the invention, for those skilled in the art For member, the invention may be variously modified and varied.Any modification made by all within the spirits and principles of the present invention, Equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.

Claims (10)

1. a kind of medical foam enzyme moisturizer, which is characterized in that by mass percentage, including following component:Anionic surface Activating agent foaming agent 1%~8%, amphoteric surfactant foaming agent 2%~10%, composite biological enzyme preparation 0.2%~ 2.0%, high molecular polymer moisturizer 3.0%~10.0%, solubilizer 2.0%~10.0%, composite corrosion inhibitor 2.0%~ 5.0% and foam stabilizer 0.3%~2.5%, surplus be water.
2. medical foam enzyme moisturizer according to claim 1, which is characterized in that by mass percentage, including following Component:It is anion surfactant foaming agent 3.0%~6.0%, amphoteric surfactant foaming agent 5.0%~8.0%, compound It is biological enzyme formulation 1.0%~1.5%, high molecular polymer moisturizer 5.0%~8.0%, solubilizer 5.0%~8.0%, compound Corrosion inhibiter 3.0%~4.0% and foam stabilizer 1.0%~2.0%, surplus are water.
3. medical foam enzyme moisturizer according to claim 1, which is characterized in that the foaming agent is selected from anionic surface The mixture of three to five kinds of formation in activating agent, amphoteric surfactant.
4. medical foam enzyme moisturizer according to claim 1, which is characterized in that the high molecular polymer moisturizer choosing One kind from the polymer of α-hydrogen-ω-hydroxyl (oxygen -1,2- second diyl).
5. medical foam enzyme moisturizer according to claim 1, which is characterized in that the composite biological enzyme preparation is selected from egg The mixture of two or more formation in white enzyme, lipase, amylase, cellulase, pectase, RNA polymerase, hydrolase.
6. medical foam enzyme moisturizer according to claim 1, which is characterized in that it is high that the moisturizer is selected from polyethylene glycol One kind in Molecularly Imprinted Polymer.
7. medical foam enzyme moisturizer according to claim 1, which is characterized in that the solubilizer is selected from propylene glycol, second One kind in alcohol, dipropylene or isopropanol.
8. medical foam enzyme moisturizer according to claim 1, which is characterized in that the corrosion inhibiter is imidazoline, amino One kind in acid, inorganic type corrosion inhibiter.
9. medical foam enzyme moisturizer according to claim 1, which is characterized in that the foam stabilizer is polyethers foam stabilizing Agent.
10. the preparation method of the medical foam enzyme moisturizer described in any one of claim 1-9, it is characterised in that:It is added It is formulated the whole or mass ratio 50%~60% of water, anion surfactant, both sexes table are then sequentially added into water Face activating agent, compound biological enzyme system, polymeric moisturizers, solubilizer, corrosion inhibiter and foam stabilizer are supplied remaining water, are persistently stirred It mixes and is uniformly dissolved up to all, obtain medical foam enzyme moisturizer.
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