CN108403896A - A kind of Chinese medicine composition of antithrombotic, Chinese medicine preparation and its preparation method and application - Google Patents
A kind of Chinese medicine composition of antithrombotic, Chinese medicine preparation and its preparation method and application Download PDFInfo
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- CN108403896A CN108403896A CN201810438266.2A CN201810438266A CN108403896A CN 108403896 A CN108403896 A CN 108403896A CN 201810438266 A CN201810438266 A CN 201810438266A CN 108403896 A CN108403896 A CN 108403896A
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Abstract
The present invention provides a kind of Chinese medicine compositions of antithrombotic, Chinese medicine preparation and its preparation method and application, are related to field of Chinese herbal.The Chinese medicine composition is mainly made of the bulk pharmaceutical chemicals of following weight：8~16 parts of 10~25 parts of the root of bidentate achyranthes, 5~20 parts of Radix Angelicae Sinensis, 25~40 parts of Radix Astragali, 15~25 parts of peach kernel, 10~25 parts of safflower, 10~20 parts of cassia twig, 12~25 parts of the root of fangji, 5~25 parts of radix paeoniae rubra, 8~30 parts of Radix Salviae Miltiorrhizae, 25~40 parts of Caulis Spatholobi, 12~30 parts of caulis lonicerae, 3~10 parts of ground bettle, 3~15 parts of Rhizoma Et Radix Notopterygii, 10~30 parts of rhizoma cyperi, 5~25 parts of excrementum pteropi and the root of three-nerved spicebush.The Chinese medicine composition of the present invention alleviates the shortcomings of traditional antithrombotic reagent drug effect is not good, therapeutic effect is not notable, medication cycle is long.The present invention has notable curative effect by the reasonable compatibility between each bulk pharmaceutical chemicals, to treatment deep vein thrombosis disease.
Description
Technical field
The present invention relates to field of Chinese herbal, in particular to a kind of Chinese medicine composition of antithrombotic, Chinese medicine preparation and its
Preparation method and purposes.
Background technology
The death rate caused by thrombus disease increases year by year in recent years, deep vein thrombosis, heart arteriovenous thrombus, capilary
Thrombus, cerebral thrombus, artery sclerosis etc. are all common thrombus diseases, and this kind of disease has seriously endangered human health and life.Blood
Bolt formation is caused by complex factors, with the factors such as vascular wall, blood platelet, blood flow velocity, blood viscosity and blood coagulation activity
It is closely related.Deep vein thrombosis refers to that blood abnormally condenses in Deep venou, belongs to veins of lower extremity reflux obstacle disease,
It is now recognized that the pathogenesis of the disease mainly has three big factor of slow blood flow, vein wall damage and hypercoagulative state.Deep vein thrombosis
Disease is clinically common postoperative complications, and treatment can cause lower limb pain, varicose vein, seriousness vein to be burst not in time
Ulcer, or even cause the severe complications such as pulmonary embolism, influence the life quality and prognosis quality of patient.
The drug of clinical treatment deep vein thrombosis disease is mainly Western medicine and Chinese patent drug at present.The use accounting of Western medicine is most
Greatly, the shortcomings of but western medicine generally existing curative effect is not notable, toxic side effect is apparent, price；Chinese patent drugs for treatment blood is used now
The case of bolt class disease is more and more, and in particular for deep vein thrombosis disease, the long-term effect of Chinese patent drugs for treatment is strong, safe nothing
Poison, the advantages that Costco Wholesale is low, treating both manifestation and root cause of disease, are gradually approved by patient.But the Chinese patent drug for the treatment of thrombus disease is still deposited at present
Effect unobvious, markedly slow, type is few, the course for the treatment of is long the deficiencies of in place of, so there is an urgent need for further research and develop it is more safely and effectively
Antithrombotic Chinese medicine preparation.
In view of this, special propose the present invention.
Invention content
The first object of the present invention is to provide a kind of Chinese medicine composition of antithrombotic, the Chinese medicine composition include the root of bidentate achyranthes,
Radix Angelicae Sinensis, Radix Astragali, peach kernel, safflower, cassia twig, the root of fangji, radix paeoniae rubra, Radix Salviae Miltiorrhizae, Caulis Spatholobi, caulis lonicerae, ground bettle, Rhizoma Et Radix Notopterygii, rhizoma cyperi, excrementum pteropi
With root of three-nerved spicebush ingredient.By the reasonable compatibility between bulk pharmaceutical chemicals, there is fine curative effect to antithrombotic, there is quick, nontoxic secondary work
The advantages that with, short treating period.
The second object of the present invention is to provide a kind of preparation method of the Chinese medicine composition of antithrombotic, and this method is will to match
It is mixed after the above-mentioned pulverizing medicinal materials just measured, it is simple and practicable.
The third object of the present invention is to provide a kind of Chinese medicine preparation of antithrombotic, which includes in antithrombotic
Drug composition and optional auxiliary material have advantage identical with above-mentioned Chinese medicine composition.
The fourth object of the present invention is to provide a kind of preparation method of the Chinese medicine preparation of antithrombotic, and the preparation method is simple
Easy, decoction is made in warm fire infusion, convenient for batch production.
The fifth object of the present invention is to provide a kind of Chinese medicine composition of antithrombotic in the drug for preparing antithrombotic
Purposes.
In order to realize that the above-mentioned purpose of the present invention, spy use following technical scheme：
In a first aspect, providing a kind of Chinese medicine composition of antithrombotic, the antithrombotic Chinese medicine composition includes following
The bulk pharmaceutical chemicals of parts by weight：10~25 parts of the root of bidentate achyranthes, 5~20 parts of Radix Angelicae Sinensis, 25~40 parts of Radix Astragali, 15~25 parts of peach kernel, safflower 10~25
Part, 10~20 parts of cassia twig, 12~25 parts of the root of fangji, 5~25 parts of radix paeoniae rubra, 8~30 parts of Radix Salviae Miltiorrhizae, 25~40 parts of Caulis Spatholobi, caulis lonicerae 12
8~16 parts of~30 parts, 3~10 parts of ground bettle, 3~15 parts of Rhizoma Et Radix Notopterygii, 10~30 parts of rhizoma cyperi, 5~25 parts of excrementum pteropi and the root of three-nerved spicebush.
Preferably, on the basis of technical solution provided by the invention, the antithrombotic Chinese medicine composition includes following
The bulk pharmaceutical chemicals of parts by weight：12~22 parts of the root of bidentate achyranthes, 8~18 parts of Radix Angelicae Sinensis, 28~38 parts of Radix Astragali, 17~23 parts of peach kernel, safflower 12~22
Part, 12~18 parts of cassia twig, 14~22 parts of the root of fangji, 8~22 parts of radix paeoniae rubra, 10~26 parts of Radix Salviae Miltiorrhizae, 28~38 parts of Caulis Spatholobi, caulis lonicerae 14
10~15 parts of~28 parts, 4~8 parts of ground bettle, 5~12 parts of Rhizoma Et Radix Notopterygii, 12~28 parts of rhizoma cyperi, 7~22 parts of excrementum pteropi and the root of three-nerved spicebush.
Preferably, on the basis of technical solution provided by the invention, the antithrombotic Chinese medicine composition includes following
The bulk pharmaceutical chemicals of parts by weight：15~18 parts of the root of bidentate achyranthes, 12~16 parts of Radix Angelicae Sinensis, 30~35 parts of Radix Astragali, 20~22 parts of peach kernel, safflower 15~20
Part, 14~16 parts of cassia twig, 16~20 parts of the root of fangji, 12~18 parts of radix paeoniae rubra, 12~22 parts of Radix Salviae Miltiorrhizae, 30~35 parts of Caulis Spatholobi, caulis lonicerae
12~14 parts of 18~22 parts, 5~7 parts of ground bettle, 7~10 parts of Rhizoma Et Radix Notopterygii, 15~25 parts of rhizoma cyperi, 10~18 parts of excrementum pteropi and the root of three-nerved spicebush.
Further, on the basis of technical solution provided by the invention, the antithrombotic Chinese medicine composition further include with
The bulk pharmaceutical chemicals of lower parts by weight：15~30 parts of bark of ash, 5~20 parts of earthworm, 20~30 parts of Rhizoma Chuanxiong, 15~30 parts of rhizoma atractylodis, Cortex Phellodendri 10~
20 parts and 5~20 parts of myrrh.
Further, on the basis of technical solution provided by the invention, the antithrombotic Chinese medicine composition further include with
The bulk pharmaceutical chemicals of lower parts by weight：7~15 parts of the root of Chinese clematis, 3~12 parts of pawpaw, 12~20 parts of madder, 20~50 parts of dandelion, Chinese violet 15
~40 parts and 5~20 parts of semiaquilegia adoxoides.
Preferably, on the basis of technical solution provided by the invention, the Chinese medicine composition of the antithrombotic includes mainly
The bulk pharmaceutical chemicals of following weight：It is 10~25 parts of the root of bidentate achyranthes, 5~20 parts of Radix Angelicae Sinensis, 25~40 parts of Radix Astragali, 15~25 parts of peach kernel, red
Spend 10~25 parts, 10~20 parts of cassia twig, 12~25 parts of the root of fangji, 5~25 parts of radix paeoniae rubra, 8~30 parts of Radix Salviae Miltiorrhizae, 25~40 parts of Caulis Spatholobi,
12~30 parts of caulis lonicerae, 3~10 parts of ground bettle, 3~15 parts of Rhizoma Et Radix Notopterygii, 10~30 parts of rhizoma cyperi, 5~25 parts of excrementum pteropi, the root of three-nerved spicebush 8~16
Part, 15~30 parts of bark of ash, 5~20 parts of earthworm, 20~30 parts of Rhizoma Chuanxiong, 15~30 parts of rhizoma atractylodis, 10~20 parts of Cortex Phellodendri, myrrh 5~20
Part, 7~15 parts of the root of Chinese clematis, 3~12 parts of pawpaw, 12~20 parts of madder, 20~50 parts of dandelion, 15~40 parts of Chinese violet and semiaquilegia adoxoides 5
~20 parts.
Second aspect, provides a kind of preparation method of antithrombotic Chinese medicine composition, and this method is by the above-mentioned of formula ratio
It is mixed after pulverizing medicinal materials, obtains the Chinese medicine composition of antithrombotic.
The third aspect, provides a kind of Chinese medicine preparation of antithrombotic, which includes the Chinese medicine composition of antithrombotic
With optional auxiliary material.
Fourth aspect provides a kind of preparation method of antithrombotic Chinese medicine preparation, includes the following steps：
(a) by the root of bidentate achyranthes of formula ratio, Radix Angelicae Sinensis, Radix Astragali, peach kernel, safflower, cassia twig, the root of fangji, radix paeoniae rubra, Radix Salviae Miltiorrhizae, Caulis Spatholobi, honeysuckle
Rattan, ground bettle, Rhizoma Et Radix Notopterygii, rhizoma cyperi, excrementum pteropi, the root of three-nerved spicebush and optionally bark of ash, earthworm, Rhizoma Chuanxiong, rhizoma atractylodis, Cortex Phellodendri, myrrh, the root of Chinese clematis,
Pawpaw, madder, dandelion, Chinese violet and semiaquilegia adoxoides are impregnated 1-3 hours with 30-40 degree water；
(b) 300-600 milliliters of water, warm fire infusion 0.5-3 hours, infusion 3-5 is added every time into the bulk pharmaceutical chemicals after immersion
It is secondary；
(c) after mixing the concoction of gained after each infusion, optionally auxiliary material is added, obtains the decoction of antithrombotic.
5th aspect provides a kind of purposes of above-mentioned antithrombotic Chinese medicine composition in the drug for preparing antithrombotic.
Compared with prior art, beneficial effects of the present invention are：
(1) antithrombotic Chinese medicine composition provided by the invention mainly include the root of bidentate achyranthes, Radix Angelicae Sinensis, Radix Astragali, peach kernel, safflower, cassia twig,
The root of fangji, radix paeoniae rubra, Radix Salviae Miltiorrhizae, Caulis Spatholobi, caulis lonicerae, ground bettle, Rhizoma Et Radix Notopterygii, rhizoma cyperi, excrementum pteropi, the root of three-nerved spicebush and optionally bark of ash, earthworm, river
The bulk pharmaceutical chemicals such as rhizome of chuanxiong, rhizoma atractylodis, Cortex Phellodendri, myrrh, the root of Chinese clematis, pawpaw, madder, dandelion, Chinese violet and semiaquilegia adoxoides, the activity in these medicinal materials
Ingredient complements each other, by the reasonable compatibility of each bulk pharmaceutical chemicals, relieved pain with relaxing tendons and activating collaterals, promoting qi circulation and removing obstruction in the collateral, promoting blood circulation and removing blood stasis, promoting circulation of blood,
The effect of dispersing swelling and dissipating binds and dispelling wind dredging collateral, obtained Chinese medicine composition is quick, has no toxic side effect, and antithrombotic effect is very aobvious
It writes, treating both manifestation and root cause of disease is uneasy to recur.Antithrombotic Chinese medicine preparation has effect identical as composition is stated.
(2) preparation method of Chinese medicine preparation of the present invention is easy to operate, by by the original of special formulation amount in preparation process
Expect medicine infusion 3-5 times, decoction is made, it is easy to use, it is produced in batches conducive to the later stage.
(3) clinical therapeutic efficacy of the invention：The present invention passes through clinical observation, has very to phlebothrombosis and arterial thrombus
Good therapeutic effect especially has good therapeutic effect to deep vein thrombosis, and patient is by taking antithrombotic Chinese medicine of the invention
After decoction treats 1~5 course for the treatment of, treated effect is up to 98% or more, and rehabilitation rate is up to 95% or more.
Specific implementation mode
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific
Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is
The conventional products that can be obtained by commercially available purchase.
According to the first aspect of the invention, provide a kind of antithrombotic Chinese medicine composition, the Chinese medicine composition mainly by
The bulk pharmaceutical chemicals of following weight are made：10~25 parts of the root of bidentate achyranthes, 5~20 parts of Radix Angelicae Sinensis, 25~40 parts of Radix Astragali, peach kernel 15~25
Part, 10~25 parts of safflower, 10~20 parts of cassia twig, 12~25 parts of the root of fangji, 5~25 parts of radix paeoniae rubra, 8~30 parts of Radix Salviae Miltiorrhizae, Caulis Spatholobi 25~
40 parts, 12~30 parts of caulis lonicerae, 3~10 parts of ground bettle, 3~15 parts of Rhizoma Et Radix Notopterygii, 10~30 parts of rhizoma cyperi, 5~25 parts of excrementum pteropi and crow
8~16 parts of medicine.
The root of bidentate achyranthes, hundred times of alias, ox stem, car pusher knee have invigorate blood circulation, ignite (blood) downlink, filling liver kidney, strengthening the bones and muscles, profit
Urinate the effect for the treatment of stranguria.
The typical but non-limiting content of the root of bidentate achyranthes is, for example, 10 parts by weight, 11 parts by weight, 12 parts by weight, 13 parts by weight, 14
Parts by weight, 15 parts by weight, 16 parts by weight, 17 parts by weight, 18 parts by weight, 19 parts by weight, 20 parts by weight, 21 parts by weight, 22 weight
Part, 23 parts by weight, 24 parts by weight or 25 parts by weight.
Radix Angelicae Sinensis, alias is dry to return, Radix Angelicae Sinensis, western Radix Angelicae Sinensis, has and enriches blood, stagnant row of invigorate blood circulation, warming and activating meridian, spasmolysis of easing pain, moisturizes
Laxation, it is immune the effect of.
The typical but non-limiting content of Radix Angelicae Sinensis is, for example, 5 parts by weight, 6 parts by weight, 7 parts by weight, 8 parts by weight, 9 weight
Part, 10 parts by weight, 11 parts by weight, 12 parts by weight, 13 parts by weight, 14 parts by weight, 15 parts by weight, 16 parts by weight, 17 parts by weight, 18
Parts by weight, 19 parts by weight or 20 parts by weight.
Radix Astragali, alias cotton stilbene, continuous stilbene, arrow stilbene, the work(with invigorating qi for consolidating superficies, arrest sweating admittedly take off, torr sore myogenic, inducing diuresis for removing edema
Effect.
The typical but non-limiting content of Radix Astragali is, for example, 25 parts by weight, 26 parts by weight, 27 parts by weight, 28 parts by weight, 29
Parts by weight, 30 parts by weight, 31 parts by weight, 32 parts by weight, 33 parts by weight, 34 parts by weight, 35 parts by weight, 36 parts by weight, 37 weight
Part, 38 parts by weight, 39 parts by weight or 40 parts by weight.
Peach kernel, alias Semen Persicae, peach-pit people have the effect of promoting blood circulation, moisturize laxation.
The typical but non-limiting content of peach kernel is, for example, 15 parts by weight, 16 parts by weight, 17 parts by weight, 18 parts by weight, 19
Parts by weight, 20 parts by weight, 21 parts by weight, 22 parts by weight, 23 parts by weight, 24 parts by weight or 25 parts by weight.
Safflower, alias red blue flower, thorn safflower, safflower have the effect of invigorate blood circulation, stasis eliminatings analgesic.
The typical but non-limiting content of safflower is, for example, 10 parts by weight, 11 parts by weight, 12 parts by weight, 13 parts by weight, 14
Parts by weight, 15 parts by weight, 16 parts by weight, 17 parts by weight, 18 parts by weight, 19 parts by weight, 20 parts by weight, 21 parts by weight, 22 weight
Part, 23 parts by weight, 24 parts by weight or 25 parts by weight.
Cassia twig, alias Liu Gui have the effect of warming meridian, sweating expelling pathogenic factors from muscles and skin, helps yang transforming qi, flat gas that spins.
The typical but non-limiting content of cassia twig is, for example, 10 parts by weight, 11 parts by weight, 12 parts by weight, 13 parts by weight, 14
Parts by weight, 15 parts by weight, 16 parts by weight, 17 parts by weight, 18 parts by weight, 19 parts by weight or 20 parts by weight.
The root of fangji, alias Fourstamen Stephania Root, Stephania tetrandra, stone toad, suspension culture of Aquilaria sinensis have inducing diuresis for removing edema, wind-expelling pain-stopping, rush down damp-heat in lower-JIAO
The benefits of.
The typical but non-limiting content of the root of fangji is, for example, 12 parts by weight, 13 parts by weight, 14 parts by weight, 15 parts by weight, 16
Parts by weight, 17 parts by weight, 18 parts by weight, 19 parts by weight, 20 parts by weight, 21 parts by weight, 22 parts by weight, 23 parts by weight, 24 weight
Part or 25 parts by weight.
Radix paeoniae rubra, alias mountain Chinese herbaceous peony, careless Chinese herbaceous peony, the wooden Chinese herbaceous peony, RADIX PAEONIAE RUBRA, with promoting blood circulation, analgesic, clearing heat and cooling blood work(
Effect.
The typical but non-limiting content of radix paeoniae rubra is, for example, 5 parts by weight, 6 parts by weight, 7 parts by weight, 8 parts by weight, 9 weight
Part, 10 parts by weight, 11 parts by weight, 12 parts by weight, 13 parts by weight, 14 parts by weight, 15 parts by weight, 16 parts by weight, 17 parts by weight, 18
Parts by weight, 19 parts by weight, 20 parts by weight, 21 parts by weight, 22 parts by weight, 23 parts by weight, 24 parts by weight or 25 parts by weight.
Radix Salviae Miltiorrhizae, alias red root, clovershrub, blood mountain root, radix salviae miltiorrhizae have stasis-dispelling and pain-killing, invigorate blood circulation, calming heart and tranquilizing mind, row
The effect of purulence, analgesic.
The typical but non-limiting content of Radix Salviae Miltiorrhizae is, for example, 8 parts by weight, 9 parts by weight, 10 parts by weight, 11 parts by weight, 12 weights
Measure part, 13 parts by weight, 14 parts by weight, 15 parts by weight, 16 parts by weight, 17 parts by weight, 18 parts by weight, 19 parts by weight, 20 parts by weight,
21 parts by weight, 22 parts by weight, 23 parts by weight, 24 parts by weight, 25 parts by weight, 26 parts by weight, 27 parts by weight, 28 parts by weight, 29 weights
Measure part or 30 parts by weight.
Caulis Spatholobi, alias blood wind, blood rattan, sargentodoxa cuneata have the effect of enriching blood, invigorate blood circulation, dredging collateral.
The typical but non-limiting content of Caulis Spatholobi be, for example, 25 parts by weight, 26 parts by weight, 27 parts by weight, 28 parts by weight,
29 parts by weight, 30 parts by weight, 31 parts by weight, 32 parts by weight, 33 parts by weight, 34 parts by weight, 35 parts by weight, 36 parts by weight, 37 weights
Measure part, 38 parts by weight, 39 parts by weight or 40 parts by weight.
Caulis lonicerae alias honeysuckle, honeysuckle stem, Caulis Lonicerae have the effect of heat-clearing, removing toxic substances, dispelling wind dredging collateral.
The typical but non-limiting content of caulis lonicerae be, for example, 12 parts by weight, 13 parts by weight, 14 parts by weight, 15 parts by weight,
16 parts by weight, 17 parts by weight, 18 parts by weight, 19 parts by weight, 20 parts by weight, 21 parts by weight, 22 parts by weight, 23 parts by weight, 24 weights
Measure part, 25 parts by weight, 26 parts by weight, 27 parts by weight, 28 parts by weight, 29 parts by weight or 30 parts by weight.
Ground bettle alias ground beetle, Eupolyphoge sinensis, tortoise, female ground beetles, have the effect of promoting blood circulation to remove blood stasis, inducing meastruation to relieve menalgia, continuous muscles and bones.
The typical but non-limiting content of ground bettle is, for example, 3 parts by weight, 4 parts by weight, 5 parts by weight, 6 parts by weight, 7 weight
Part, 8 parts by weight, 9 parts by weight or 10 parts by weight.
Rhizoma Et Radix Notopterygii alias silkworm Qiang, RHIZOMA SEU RADIX NOTOPTERYGII, RHIZOMA SEU RADIX NOTOPTERYGII, Koji have the effect of cold dispelling, wind-dispelling, dehumidifying, analgesic.
The typical but non-limiting content of Rhizoma Et Radix Notopterygii is, for example, 3 parts by weight, 4 parts by weight, 5 parts by weight, 6 parts by weight, 7 weight
Part, 8 parts by weight, 9 parts by weight, 10 parts by weight, 11 parts by weight, 12 parts by weight, 13 parts by weight, 14 parts by weight or 15 parts by weight.
Rhizoma cyperi alias nutgrass flatsedge, the rhizome of nutgrass flatsedge, convexutricle sedge herb, fragrant head grass, have the effect of promoting qi circulation and removing obstruction in the collateral, menstruction regulating and pain relieving, tocolysis.
The typical but non-limiting content of rhizoma cyperi is, for example, 10 parts by weight, 11 parts by weight, 12 parts by weight, 13 parts by weight, 14
Parts by weight, 15 parts by weight, 16 parts by weight, 17 parts by weight, 18 parts by weight, 19 parts by weight, 20 parts by weight, 21 parts by weight, 22 weight
Part, 23 parts by weight, 24 parts by weight, 25 parts by weight, 26 parts by weight, 27 parts by weight, 28 parts by weight, 29 parts by weight or 30 parts by weight.
The clever fat of excrementum pteropi alias medicine sheet, clever fat, sugar, clever fat rice, have a promoting blood circulation to remove blood stasis, promoting circulation of blood analgesic, fries charcoal hemostasis work(
Effect.
The typical but non-limiting content of excrementum pteropi is, for example, 5 parts by weight, 6 parts by weight, 7 parts by weight, 8 parts by weight, 9 weight
Part, 10 parts by weight, 11 parts by weight, 12 parts by weight, 13 parts by weight, 14 parts by weight, 15 parts by weight, 16 parts by weight, 17 parts by weight, 18
Parts by weight, 19 parts by weight, 20 parts by weight, 21 parts by weight, 22 parts by weight, 23 parts by weight, 24 parts by weight or 25 parts by weight.
Root of three-nerved spicebush alias balcony crow, platform crow, fragrant osmanthus camphor tree, copper coin bavin have pleasant analgesic, warming kidney for dispelling cold, open the effect of strongly fragrant.
The typical but non-limiting content of the root of three-nerved spicebush is, for example, 8 parts by weight, 9 parts by weight, 10 parts by weight, 11 parts by weight, 12 weights
Measure part, 13 parts by weight, 14 parts by weight, 15 parts by weight or 16 parts by weight.
" mainly by " of the present invention, it is intended that it can also include other components especially except described group, such as bark of ash,
Earthworm, Rhizoma Chuanxiong, rhizoma atractylodis, Cortex Phellodendri and myrrh etc., these other components assign antithrombotic Chinese medicine composition different characteristics.Except this it
Outside, " mainly by " of the present invention, may be replaced by enclosed " for " or " by ... form ".
Antithrombotic Chinese medicine composition provided by the invention mainly by the root of bidentate achyranthes, Radix Angelicae Sinensis, Radix Astragali, peach kernel, safflower, cassia twig, the root of fangji,
Radix paeoniae rubra, Radix Salviae Miltiorrhizae, Caulis Spatholobi, caulis lonicerae, ground bettle, Rhizoma Et Radix Notopterygii, rhizoma cyperi, excrementum pteropi and the root of three-nerved spicebush are made of bulk pharmaceutical chemicals, pass through each raw material
The reasonable compatibility of medicine, above-mentioned composition have relaxing tendons and activating collaterals, promoting qi circulation and removing obstruction in the collateral, promoting blood circulation and removing blood stasis, promoting circulation of blood analgesic, dispersing swelling and dissipating binds and dispelling wind
, there is antithrombotic in the effect of dredging collateral fine curative effect.The traditional Chinese herbal decoction composition proportion science, drug effect does not stimulate mildly, to human body
It has no toxic side effect, can fundamentally treat thrombus disease, it is uneasy to recur after treatment.
In a preferred embodiment, antithrombotic Chinese medicine composition is mainly by the bulk pharmaceutical chemicals system of following weight
At：12~22 parts of the root of bidentate achyranthes, 8~18 parts of Radix Angelicae Sinensis, 28~38 parts of Radix Astragali, 17~23 parts of peach kernel, 12~22 parts of safflower, cassia twig 12~18
Part, 14~22 parts of the root of fangji, 8~22 parts of radix paeoniae rubra, 10~26 parts of Radix Salviae Miltiorrhizae, 28~38 parts of Caulis Spatholobi, 14~28 parts of caulis lonicerae, ground bettle
10~15 parts of 4~8 parts, 5~12 parts of Rhizoma Et Radix Notopterygii, 12~28 parts of rhizoma cyperi, 7~22 parts of excrementum pteropi and the root of three-nerved spicebush.
In a preferred embodiment, antithrombotic Chinese medicine composition is mainly by the bulk pharmaceutical chemicals system of following weight
At：15~18 parts of the root of bidentate achyranthes, 12~16 parts of Radix Angelicae Sinensis, 30~35 parts of Radix Astragali, 20~22 parts of peach kernel, 15~20 parts of safflower, cassia twig 14~
16 parts, 16~20 parts of the root of fangji, 12~18 parts of radix paeoniae rubra, 12~22 parts of Radix Salviae Miltiorrhizae, 30~35 parts of Caulis Spatholobi, 18~22 parts of caulis lonicerae, soil
12~14 parts of 5~7 parts of soft-shelled turtle worm, 7~10 parts of Rhizoma Et Radix Notopterygii, 15~25 parts of rhizoma cyperi, 10~18 parts of excrementum pteropi and the root of three-nerved spicebush.
In a preferred embodiment, antithrombotic Chinese medicine composition is mainly by the bulk pharmaceutical chemicals system of following weight
At：15~18 parts of the root of bidentate achyranthes, 12~16 parts of Radix Angelicae Sinensis, 30~35 parts of Radix Astragali, 20~22 parts of peach kernel, 15~20 parts of safflower, cassia twig 14~
16 parts, 16~20 parts of the root of fangji, 12~18 parts of radix paeoniae rubra, 12~22 parts of Radix Salviae Miltiorrhizae, 30~35 parts of Caulis Spatholobi, 18~22 parts of caulis lonicerae, soil
12~14 parts of 5~7 parts of soft-shelled turtle worm, 7~10 parts of Rhizoma Et Radix Notopterygii, 15~25 parts of rhizoma cyperi, 10~18 parts of excrementum pteropi and the root of three-nerved spicebush.
By further optimizing the proportion relation of each bulk pharmaceutical chemicals, therapeutic effect can be further improved.
In a preferred embodiment, antithrombotic Chinese medicine composition further includes the bulk pharmaceutical chemicals of following weight：
5~20 parts of 15~30 parts of bark of ash, 5~20 parts of earthworm, 20~30 parts of Rhizoma Chuanxiong, 15~30 parts of rhizoma atractylodis, 10~20 parts of Cortex Phellodendri and myrrh.
Bark of ash alias gentiana straminea, radix gentiane dahuvicae, RADIX GENTIANAE MACROPHYLLAE, plait Macrophylla, have wet relaxing muscles and tendons network, evacuate pathogenic wind, clearind deficient heat, stopping numbness pain it
Effect.
The typical but non-limiting content of bark of ash is, for example, 15 parts by weight, 16 parts by weight, 17 parts by weight, 18 parts by weight, 19
Parts by weight, 20 parts by weight, 21 parts by weight, 22 parts by weight, 23 parts by weight, 24 parts by weight, 25 parts by weight, 26 parts by weight, 27 weight
Part, 28 parts by weight, 29 parts by weight or 30 parts by weight.
Earthworm has the effect of clearing and activating the channels and collaterals, clearing heat for calming endogenous wind, clearing lung, relieving asthma, reducing fever and causing diuresis.
The typical but non-limiting content of earthworm is, for example, 5 parts by weight, 6 parts by weight, 7 parts by weight, 8 parts by weight, 9 weight
Part, 10 parts by weight, 11 parts by weight, 12 parts by weight, 13 parts by weight, 14 parts by weight, 15 parts by weight, 16 parts by weight, 17 parts by weight, 18
Parts by weight, 19 parts by weight or 20 parts by weight.
It is poor that poor, rhizome of chuanxiong perfume (or spice) fruit, Hu Maxian rhizomes of chuanxiong, rhizome of chuanxiong are brought up in Rhizoma Chuanxiong alias mountain, have blood-activating and qi-promoting, wind-expelling pain-stopping, promote breath and open depression it
Effect.
The typical but non-limiting content of Rhizoma Chuanxiong is, for example, 20 parts by weight, 21 parts by weight, 22 parts by weight, 23 parts by weight, 24
Parts by weight, 25 parts by weight, 26 parts by weight, 27 parts by weight, 28 parts by weight, 29 parts by weight or 30 parts by weight.
The red art of rhizoma atractylodis alias, pipette tips dish, green art, magic arts, have the effect of drying damp and strengthening spleen, expelling wind and clearing away cold, Xie Yu, improving eyesight.
The typical but non-limiting content of rhizoma atractylodis is, for example, 15 parts by weight, 16 parts by weight, 17 parts by weight, 18 parts by weight, 19
Parts by weight, 20 parts by weight, 21 parts by weight, 22 parts by weight, 23 parts by weight, 24 parts by weight, 25 parts by weight, 26 parts by weight, 27 weight
Part, 28 parts by weight, 29 parts by weight or 30 parts by weight.
Cortex Phellodendri alias bark of a cork tree wood, bark of a cork tree skin, cork tree have the effect of heat-clearing, eliminating dampness, purging intense heat, removing toxic substances.
The typical but non-limiting content of Cortex Phellodendri is, for example, 10 parts by weight, 11 parts by weight, 12 parts by weight, 13 parts by weight, 14
Parts by weight, 15 parts by weight, 16 parts by weight, 17 parts by weight, 18 parts by weight, 19 parts by weight or 20 parts by weight.
Myrrh alias myrrh, bright myrrh have the effect of removing blood stasis and analgesics, detumescence and promoting granulation.
The typical but non-limiting content of myrrh is, for example, 5 parts by weight, 6 parts by weight, 7 parts by weight, 8 parts by weight, 9 weight
Part, 10 parts by weight, 11 parts by weight, 12 parts by weight, 13 parts by weight, 14 parts by weight, 15 parts by weight, 16 parts by weight, 17 parts by weight, 18
Parts by weight, 19 parts by weight or 20 parts by weight.
In a preferred embodiment, antithrombotic Chinese medicine composition further includes the bulk pharmaceutical chemicals of following weight：
7~15 parts of the root of Chinese clematis, 3~12 parts of pawpaw, 12~20 parts of madder, 20~50 parts of dandelion, 15~40 parts of Chinese violet and semiaquilegia adoxoides 5~20
Part.
Root of Chinese clematis alias radix smilacis sieboldi, hundred roots, tiger must, cuneate lespedezas, have remove obstruction in channels to relieve pain, dispelling wind and eliminating dampness, dissolving phlegm
The effect of saliva, dissipate the hypochondriac lump.
The typical but non-limiting content of the root of Chinese clematis is, for example, 7 parts by weight, 8 parts by weight, 9 parts by weight, 10 parts by weight, 11 weights
Measure part, 12 parts by weight, 13 parts by weight, 14 parts by weight or 15 parts by weight.
Pawpaw alias chaenomeles lagenaria, iron pin pear, wrinkled papaya, Xuancheng's pawpaw, have relaxing tendons and activating collaterals, soothing the liver, stomach dampness elimination it
Effect.
The typical but non-limiting content of pawpaw is, for example, 3 parts by weight, 4 parts by weight, 5 parts by weight, 6 parts by weight, 7 weight
Part, 8 parts by weight, 9 parts by weight, 10 parts by weight, 11 parts by weight or 12 parts by weight.
Madder alias psilate catchweed bedstraw herb, blood activating grass, carriage, yellow angledtwig magnoliavine root stem and leaf have the effect of cool blood, hemostasis, dissolving stasis, promoting menstruation.
The typical but non-limiting content of madder is, for example, 12 parts by weight, 13 parts by weight, 14 parts by weight, 15 parts by weight, 16
Parts by weight, 17 parts by weight, 18 parts by weight, 19 parts by weight or 20 parts by weight.
Dandelion alias dandelion, Po Poding, Fu Gongying, Pu Gongcao have clearing heat and detoxicating, dispersing swelling and dissipating binds, diuresis logical
The effect of leaching.
The typical but non-limiting content of dandelion be, for example, 20 parts by weight, 21 parts by weight, 22 parts by weight, 23 parts by weight,
24 parts by weight, 25 parts by weight, 26 parts by weight, 27 parts by weight, 28 parts by weight, 29 parts by weight, 30 parts by weight, 31 parts by weight, 32 weights
Measure part, 33 parts by weight, 34 parts by weight, 35 parts by weight, 36 parts by weight, 37 parts by weight, 38 parts by weight, 39 parts by weight, 40 parts by weight,
41 parts by weight, 42 parts by weight, 43 parts by weight, 44 parts by weight, 45 parts by weight, 46 parts by weight, 47 parts by weight, 48 parts by weight, 49 weights
Measure part or 50 parts by weight.
Chinese violet alias arrow grass, walk alone tiger, Bunge Corydalis Herb, wishful grass have heat-clearing, dampness removing, the efficacy of removing toxicity for detumescence effect.
The typical but non-limiting content of Chinese violet is, for example, 15 parts by weight, 16 parts by weight, 17 parts by weight, 18 parts by weight, 19
Parts by weight, 20 parts by weight, 21 parts by weight, 22 parts by weight, 23 parts by weight, 24 parts by weight, 25 parts by weight, 26 parts by weight, 27 weight
Part, 28 parts by weight, 29 parts by weight, 30 parts by weight, 31 parts by weight, 32 parts by weight, 33 parts by weight, 34 parts by weight, 35 parts by weight, 36
Parts by weight, 37 parts by weight, 38 parts by weight, 39 parts by weight or 40 parts by weight.
Semiaquilegia adoxoides alias Gynura bicolor, stone-like omphalia grass, summer without track, the small rhizome of Chinese monkshood, have heat-clearing, removing toxic substances, detumescence, dissipating bind, diuresis it
Effect.
The typical but non-limiting content of semiaquilegia adoxoides is, for example, 5 parts by weight, 6 parts by weight, 7 parts by weight, 8 parts by weight, 9 weight
Part, 10 parts by weight, 11 parts by weight, 12 parts by weight, 13 parts by weight, 14 parts by weight, 15 parts by weight, 16 parts by weight, 17 parts by weight, 18
Parts by weight, 19 parts by weight or 20 parts by weight.
By bark of ash, earthworm, Rhizoma Chuanxiong, rhizoma atractylodis, Cortex Phellodendri, myrrh, the root of Chinese clematis, pawpaw, madder, Pu Gong that certain content is added
English, Chinese violet and semiaquilegia adoxoides can further promote the blood-activating and qi-promoting of Chinese medicine composition, the advantageous effect of channels sootheing and network vessel quickening, removing blood stasis and analgesics.
Preferably, a kind of typical antithrombotic Chinese medicine composition, including following parts by weight are bulk pharmaceutical chemicals：The root of bidentate achyranthes 10~25
Part, 5~20 parts of Radix Angelicae Sinensis, 25~40 parts of Radix Astragali, 15~25 parts of peach kernel, 10~25 parts of safflower, 10~20 parts of cassia twig, the root of fangji 12~25
Part, 5~25 parts of radix paeoniae rubra, 8~30 parts of Radix Salviae Miltiorrhizae, 25~40 parts of Caulis Spatholobi, 12~30 parts of caulis lonicerae, 3~10 parts of ground bettle, Rhizoma Et Radix Notopterygii 3
~15 parts, 10~30 parts of rhizoma cyperi, 5~25 parts of excrementum pteropi, 8~16 parts of the root of three-nerved spicebush, 15~30 parts of bark of ash, 5~20 parts of earthworm, Rhizoma Chuanxiong 20
~30 parts, 15~30 parts of rhizoma atractylodis, 10~20 parts of Cortex Phellodendri, 5~20 parts of myrrh, 7~15 parts of the root of Chinese clematis, 3~12 parts of pawpaw, madder 12
5~20 parts of~20 parts, 20~50 parts of dandelion, 15~40 parts of Chinese violet and semiaquilegia adoxoides.
According to the second aspect of the invention, a kind of preparation method of antithrombotic Chinese medicine composition is provided, feature exists
In including the following steps：
By the root of bidentate achyranthes of formula ratio, Radix Angelicae Sinensis, Radix Astragali, peach kernel, safflower, cassia twig, the root of fangji, radix paeoniae rubra, Radix Salviae Miltiorrhizae, Caulis Spatholobi, caulis lonicerae,
Ground bettle, Rhizoma Et Radix Notopterygii, rhizoma cyperi, excrementum pteropi, the root of three-nerved spicebush and optionally bark of ash, earthworm, rhizoma atractylodis, Cortex Phellodendri, myrrh, the root of Chinese clematis, pawpaw, madder
Grass, dandelion, Chinese violet and semiaquilegia adoxoides mix after crushing, and obtain the Chinese medicine composition of antithrombotic.
According to the third aspect of the present invention, a kind of Chinese medicine preparation of antithrombotic is provided, which includes anti-blood
The Chinese medicine composition of bolt and optionally auxiliary material.The Chinese medicine preparation has effects that the identical of above-mentioned Chinese medicine composition.
According to the fourth aspect of the present invention, a kind of preparation method of the Chinese medicine preparation of antithrombotic is provided, which is characterized in that
Include the following steps：
(a) by the root of bidentate achyranthes of formula ratio, Radix Angelicae Sinensis, Radix Astragali, peach kernel, safflower, cassia twig, the root of fangji, radix paeoniae rubra, Radix Salviae Miltiorrhizae, Caulis Spatholobi, honeysuckle
Rattan, ground bettle, Rhizoma Et Radix Notopterygii, rhizoma cyperi, excrementum pteropi, the root of three-nerved spicebush and optionally bark of ash, earthworm, Rhizoma Chuanxiong, rhizoma atractylodis, Cortex Phellodendri, myrrh, the root of Chinese clematis,
Pawpaw, madder, dandelion, Chinese violet and semiaquilegia adoxoides are impregnated 1-3 hours with 30-40 DEG C of water；
(b) 300-600 milliliters of water are added every time into the bulk pharmaceutical chemicals after immersion, after big fire is boiled, warm fire infusion 0.5-3 is small
When, infusion 3-5 times；
(c) after mixing the concoction of gained after each infusion, optionally auxiliary material is added, obtains the decoction of antithrombotic.
Typical but non-limiting coolant-temperature gage be 30 DEG C, 31 DEG C, 32 DEG C, 33 DEG C, 34 DEG C, 35 DEG C, 36 DEG C, 37 DEG C, 38 DEG C,
39 DEG C or 40 DEG C.
By by the bulk pharmaceutical chemicals infusion of formula ratio, decoction being made, the method is simple and practicable, does not destroy its drug effect, makes drug
Active constituent be fully dissolved out.Non-medical personage can voluntarily prepare after buying corresponding bulk pharmaceutical chemicals, without using special installation
And tool.Preparation method is simple, convenient for batch production.
Preferably, amount of water is 300-450 milliliters.
Preferably, warm fire infusion 3 times, warm fire infusion 1-2 hours, takes juice to store after the 1st big fire is boiled；2nd time and the 3rd
Secondary warm fire infusion 0.5-1 hours, takes juice to store.
The instructions of taking of above-mentioned decoction：Adult is each taking 100-150 milliliters, daily 3 times；Children's per kilogram of body weight
2-3 milliliters are taken, daily 3 times.
One auxiliary is taken 3 days, and 9 days as one therapeutic course is continuously taken.
According to the fifth aspect of the present invention, a kind of Chinese medicine composition of antithrombotic is provided in the drug for preparing antithrombotic
Purposes.
Embodiment 1
Bulk pharmaceutical chemicals are weighed by following weight parts：10 parts of the root of bidentate achyranthes, 20 parts of Radix Angelicae Sinensis, 25 parts of Radix Astragali, 25 parts of peach kernel, 10 parts of safflower,
20 parts of cassia twig, 12 parts of the root of fangji, 25 parts of radix paeoniae rubra, 8 parts of Radix Salviae Miltiorrhizae, 40 parts of Caulis Spatholobi, 12 parts of caulis lonicerae, 10 parts of ground bettle, 3 parts of Rhizoma Et Radix Notopterygii,
16 parts of 30 parts of rhizoma cyperi, 5 parts of excrementum pteropi and the root of three-nerved spicebush.The broken rear 40 DEG C of water of above-mentioned raw materials medicinal powder are impregnated 3 hours, warm fire infusion 3 times,
The concoction of gained obtains the decoction of antithrombotic after mixing after 3 infusions.
Embodiment 2
Bulk pharmaceutical chemicals are weighed by following weight parts：25 parts of the root of bidentate achyranthes, 5 parts of Radix Angelicae Sinensis, 40 parts of Radix Astragali, 15 parts of peach kernel, 25 parts of safflower, osmanthus
10 parts of branch, 25 parts of the root of fangji, 5 parts of radix paeoniae rubra, 30 parts of Radix Salviae Miltiorrhizae, 25 parts of Caulis Spatholobi, 30 parts of caulis lonicerae, 3 parts of ground bettle, 15 parts of Rhizoma Et Radix Notopterygii, perfume
8 parts of attached 10 parts, 25 parts of excrementum pteropi and the root of three-nerved spicebush.The broken rear 40 DEG C of water of above-mentioned raw materials medicinal powder are impregnated 3 hours, warm fire infusion 3 times, 3
The concoction of gained obtains the decoction of antithrombotic after mixing after secondary infusion.
Embodiment 3
Bulk pharmaceutical chemicals are weighed by following weight parts：15 parts of the root of bidentate achyranthes, 15 parts of Radix Angelicae Sinensis, 30 parts of Radix Astragali, 20 parts of peach kernel, 20 parts of safflower,
15 parts of cassia twig, 18 parts of the root of fangji, 15 parts of radix paeoniae rubra, 20 parts of Radix Salviae Miltiorrhizae, 32 parts of Caulis Spatholobi, 20 parts of caulis lonicerae, 5 parts of ground bettle, 10 parts of Rhizoma Et Radix Notopterygii,
12 parts of 20 parts of rhizoma cyperi, 15 parts of excrementum pteropi and the root of three-nerved spicebush.The broken rear 40 DEG C of water of above-mentioned raw materials medicinal powder are impregnated 3 hours, warm fire infusion 3
Secondary, the concoction of gained obtains the decoction of antithrombotic after mixing after 3 infusions.
Embodiment 4
Bulk pharmaceutical chemicals are weighed by following weight parts：20 parts of the root of bidentate achyranthes, 18 parts of Radix Angelicae Sinensis, 35 parts of Radix Astragali, 22 parts of peach kernel, 22 parts of safflower,
18 parts of cassia twig, 20 parts of the root of fangji, 20 parts of radix paeoniae rubra, 25 parts of Radix Salviae Miltiorrhizae, 35 parts of Caulis Spatholobi, 25 parts of caulis lonicerae, 7 parts of ground bettle, 8 parts of Rhizoma Et Radix Notopterygii,
10 parts of 15 parts of rhizoma cyperi, 20 parts of excrementum pteropi and the root of three-nerved spicebush.The broken rear 40 DEG C of water of above-mentioned raw materials medicinal powder are impregnated 3 hours, warm fire infusion 3
Secondary, the concoction of gained obtains the decoction of antithrombotic after mixing after 3 infusions.
Embodiment 5
Bulk pharmaceutical chemicals are weighed by following weight parts：22 parts of the root of bidentate achyranthes, 20 parts of Radix Angelicae Sinensis, 33 parts of Radix Astragali, 24 parts of peach kernel, 25 parts of safflower,
15 parts of cassia twig, 22 parts of the root of fangji, 22 parts of radix paeoniae rubra, 28 parts of Radix Salviae Miltiorrhizae, 38 parts of Caulis Spatholobi, 27 parts of caulis lonicerae, 8 parts of ground bettle, 12 parts of Rhizoma Et Radix Notopterygii,
15 parts of 25 parts of rhizoma cyperi, 25 parts of excrementum pteropi and the root of three-nerved spicebush.The broken rear 40 DEG C of water of above-mentioned raw materials medicinal powder are impregnated 3 hours, warm fire infusion 3
Secondary, the concoction of gained obtains the decoction of antithrombotic after mixing after 3 infusions.
Embodiment 6
Bulk pharmaceutical chemicals are weighed by following weight parts：22 parts of the root of bidentate achyranthes, 20 parts of Radix Angelicae Sinensis, 33 parts of Radix Astragali, 24 parts of peach kernel, 25 parts of safflower,
15 parts of cassia twig, 22 parts of the root of fangji, 22 parts of radix paeoniae rubra, 28 parts of Radix Salviae Miltiorrhizae, 38 parts of Caulis Spatholobi, 27 parts of caulis lonicerae, 8 parts of ground bettle, 12 parts of Rhizoma Et Radix Notopterygii,
25 parts of 15 parts of 25 parts of rhizoma cyperi, 25 parts of excrementum pteropi and the root of three-nerved spicebush, 20 parts of bark of ash, 15 parts of earthworm and Rhizoma Chuanxiong.By above-mentioned raw materials medicinal powder it is broken after
It is impregnated 3 hours with 40 DEG C of water, warm fire infusion 3 times, the concoction of gained obtains the decoction of antithrombotic after mixing after 3 infusions.
Embodiment 7
Bulk pharmaceutical chemicals are weighed by following weight parts：22 parts of the root of bidentate achyranthes, 20 parts of Radix Angelicae Sinensis, 33 parts of Radix Astragali, 24 parts of peach kernel, 25 parts of safflower,
15 parts of cassia twig, 22 parts of the root of fangji, 22 parts of radix paeoniae rubra, 28 parts of Radix Salviae Miltiorrhizae, 38 parts of Caulis Spatholobi, 27 parts of caulis lonicerae, 8 parts of ground bettle, 12 parts of Rhizoma Et Radix Notopterygii,
15 parts of 15 parts of 25 parts of rhizoma cyperi, 25 parts of excrementum pteropi and the root of three-nerved spicebush, 20 parts of rhizoma atractylodis, 15 parts of Cortex Phellodendri and myrrh.By above-mentioned raw materials medicinal powder it is broken after
It is impregnated 3 hours with 40 DEG C of water, warm fire infusion 3 times, the concoction of gained obtains the decoction of antithrombotic after mixing after 3 infusions.
Embodiment 8
Bulk pharmaceutical chemicals are weighed by following weight parts：22 parts of the root of bidentate achyranthes, 20 parts of Radix Angelicae Sinensis, 33 parts of Radix Astragali, 24 parts of peach kernel, 25 parts of safflower,
15 parts of cassia twig, 22 parts of the root of fangji, 22 parts of radix paeoniae rubra, 28 parts of Radix Salviae Miltiorrhizae, 38 parts of Caulis Spatholobi, 27 parts of caulis lonicerae, 8 parts of ground bettle, 12 parts of Rhizoma Et Radix Notopterygii,
15 parts of 15 parts of 25 parts of rhizoma cyperi, 25 parts of excrementum pteropi and the root of three-nerved spicebush, 10 parts of the root of Chinese clematis, 10 parts of pawpaw and madder.Above-mentioned raw materials medicinal powder is broken
It is impregnated 3 hours with 40 DEG C of water afterwards, warm fire infusion 3 times, the concoction of gained obtains the soup of antithrombotic after mixing after 3 infusions
Agent.
Embodiment 9
Bulk pharmaceutical chemicals are weighed by following weight parts：22 parts of the root of bidentate achyranthes, 20 parts of Radix Angelicae Sinensis, 33 parts of Radix Astragali, 24 parts of peach kernel, 25 parts of safflower,
15 parts of cassia twig, 22 parts of the root of fangji, 22 parts of radix paeoniae rubra, 28 parts of Radix Salviae Miltiorrhizae, 38 parts of Caulis Spatholobi, 27 parts of caulis lonicerae, 8 parts of ground bettle, 12 parts of Rhizoma Et Radix Notopterygii,
15 parts of 15 parts of 25 parts of rhizoma cyperi, 25 parts of excrementum pteropi and the root of three-nerved spicebush, 35 parts of dandelion, 32 parts of Chinese violet and semiaquilegia adoxoides.Above-mentioned raw materials medicinal powder is broken
It is impregnated 3 hours with 40 DEG C of water afterwards, warm fire infusion 3 times, the concoction of gained obtains the soup of antithrombotic after mixing after 3 infusions
Agent.
Embodiment 10
Bulk pharmaceutical chemicals are weighed by following weight parts：22 parts of the root of bidentate achyranthes, 20 parts of Radix Angelicae Sinensis, 33 parts of Radix Astragali, 24 parts of peach kernel, 25 parts of safflower,
15 parts of cassia twig, 22 parts of the root of fangji, 22 parts of radix paeoniae rubra, 28 parts of Radix Salviae Miltiorrhizae, 38 parts of Caulis Spatholobi, 27 parts of caulis lonicerae, 8 parts of ground bettle, 12 parts of Rhizoma Et Radix Notopterygii,
25 parts of rhizoma cyperi, 15 parts of the root of three-nerved spicebush, 20 parts of bark of ash, 15 parts of earthworm, 25 parts of Rhizoma Chuanxiong, 20 parts of rhizoma atractylodis, 15 parts of Cortex Phellodendri, does not have 25 parts of excrementum pteropi
15 parts of 15 parts of medicine, 10 parts of the root of Chinese clematis, 10 parts of pawpaw, 15 parts of madder, 35 parts of dandelion, 32 parts of Chinese violet and semiaquilegia adoxoides.By above-mentioned raw materials
It is impregnated 3 hours with 40 DEG C of water after medicinal powder is broken, warm fire infusion 3 times, the concoction of gained obtains antithrombotic after mixing after 3 infusions
Decoction.
Comparative example 1
Bulk pharmaceutical chemicals are weighed by following weight parts：22 parts of the root of bidentate achyranthes, 20 parts of Radix Angelicae Sinensis, 33 parts of Radix Astragali, 24 parts of peach kernel, 25 parts of safflower,
15 parts of cassia twig, 22 parts of the root of fangji, 22 parts of radix paeoniae rubra, 28 parts of Radix Salviae Miltiorrhizae, 38 parts of Caulis Spatholobi, 27 parts of caulis lonicerae, 8 parts of ground bettle, 25 parts of rhizoma cyperi,
15 parts of 25 parts of excrementum pteropi and the root of three-nerved spicebush.The broken rear 40 DEG C of water of above-mentioned raw materials medicinal powder are impregnated 3 hours, warm fire infusion 3 times, 3 infusions
The concoction of gained obtains the decoction of antithrombotic after mixing afterwards.
Comparative example 2
Bulk pharmaceutical chemicals are weighed by following weight parts：22 parts of the root of bidentate achyranthes, 20 parts of Radix Angelicae Sinensis, 33 parts of Radix Astragali, 24 parts of peach kernel, 25 parts of safflower,
15 parts of cassia twig, 22 parts of the root of fangji, 22 parts of radix paeoniae rubra, 28 parts of Radix Salviae Miltiorrhizae, 38 parts of Caulis Spatholobi, 27 parts of caulis lonicerae, 8 parts of ground bettle, excrementum pteropi 25
15 parts of part and the root of three-nerved spicebush.The broken rear 40 DEG C of water of above-mentioned raw materials medicinal powder are impregnated 3 hours, warm fire infusion 3 times, gained after 3 infusions
Concoction obtains the decoction of antithrombotic after mixing.
Comparative example 3
Bulk pharmaceutical chemicals are weighed by following weight parts：22 parts of the root of bidentate achyranthes, 20 parts of Radix Angelicae Sinensis, 33 parts of Radix Astragali, 24 parts of peach kernel, 25 parts of safflower,
15 parts of cassia twig, 22 parts of the root of fangji, 22 parts of radix paeoniae rubra, 28 parts of Radix Salviae Miltiorrhizae, 38 parts of Caulis Spatholobi, 27 parts of caulis lonicerae, 8 parts of ground bettle and the root of three-nerved spicebush 15
Part.The broken rear 40 DEG C of water of above-mentioned raw materials medicinal powder are impregnated 3 hours, warm fire infusion 3 times, the concoction mixing of gained is equal after 3 infusions
The decoction of antithrombotic is obtained after even.
Comparative example 4
Bulk pharmaceutical chemicals are weighed by following weight parts：22 parts of the root of bidentate achyranthes, 20 parts of Radix Angelicae Sinensis, 33 parts of Radix Astragali, 24 parts of peach kernel, 25 parts of safflower,
15 parts of cassia twig, 22 parts of the root of fangji, 22 parts of radix paeoniae rubra, 28 parts of Radix Salviae Miltiorrhizae, 38 parts of Caulis Spatholobi, 27 parts of caulis lonicerae, 8 parts of ground bettle.By above-mentioned original
Expect to be impregnated 3 hours with 40 DEG C of water after medicinal powder is broken, warm fire infusion 3 times, the concoction of gained obtains anti-blood after mixing after 3 infusions
The decoction of bolt.
Comparative example 5
Bulk pharmaceutical chemicals are weighed by following weight parts：8 parts of the root of bidentate achyranthes, 22 parts of Radix Angelicae Sinensis, 24 parts of Radix Astragali, 12 parts of peach kernel, 8 parts of safflower, osmanthus
22 parts of branch, 10 parts of the root of fangji, 22 parts of radix paeoniae rubra, 5 parts of Radix Salviae Miltiorrhizae, 20 parts of Caulis Spatholobi, 10 parts of caulis lonicerae, 12 parts of ground bettle, 16 parts of Rhizoma Et Radix Notopterygii, perfume
5 parts of attached 8 parts, 28 parts of excrementum pteropi and the root of three-nerved spicebush.The broken rear 40 DEG C of water of above-mentioned raw materials medicinal powder are impregnated 3 hours, warm fire infusion 3 times, 3 times
The concoction of gained obtains the decoction of antithrombotic after mixing after infusion.
Comparative example 6
The Chinese patent drug of commercially available treatment thrombus：XUESHUANTONG JIAONANG.Be grown up by specification oral medication, one time 3, one day three
It is secondary, every 0.5g.
Experimental example
With the Chinese patent drug of the obtained traditional Chinese herbal decoction of above-described embodiment 1-10 and comparative example 1-5 and comparative example 6 to Deep venou
Thrombus disease patient is grouped clinical test：
One, basic condition
Case 800, wherein male 400, women 400, the age is between 30 years old to 80 years old.Patient is randomly divided into 16
Group, every group each 50, the 1st group of traditional Chinese herbal decoction using embodiment 1 is treated, and the 2nd group of traditional Chinese herbal decoction using embodiment 2 is treated,
The 3rd group of traditional Chinese herbal decoction using embodiment 3 is treated, and the 4th group of traditional Chinese herbal decoction using embodiment 4 is treated, and the 5th group uses embodiment
5 traditional Chinese herbal decoction treatment, the 6th group of traditional Chinese herbal decoction using embodiment 6 are treated, and the 7th group is controlled using the traditional Chinese herbal decoction of embodiment 7
It treats, the 8th group of traditional Chinese herbal decoction using embodiment 8 is treated, and the 9th group of traditional Chinese herbal decoction using embodiment 9 is treated, and the 10th group using real
The traditional Chinese herbal decoction treatment of example 10 is applied, the 11st group of traditional Chinese herbal decoction using comparative example 1 is treated, the 12nd group of Chinese medicine for using comparative example 2
Decoction is treated, and the 13rd group of traditional Chinese herbal decoction using comparative example 3 is treated, and the 14th group of traditional Chinese herbal decoction using comparative example 4 is treated, and the 15th
Group is treated using the traditional Chinese herbal decoction of comparative example 5, the 16th group of Chinese patent drugs for treatment for using comparative example 6.
Two, standard is treated
It cures：Clinical symptoms all disappear, and color Doppler ultrasonography result is shown：Phlebothrombosis picture disappears, blood flow
Unimpeded, no lateral thrombus levies picture.
It is effective：Clinical symptoms partial disappearance, color Doppler ultrasonography result are shown：Phlebothrombosis part is unimpeded, blood
Stream part is unimpeded, and lateral thrombus sign is as reducing.
Effectively：Clinical symptom relief, color Doppler ultrasonography result are shown：Phlebothrombosis picture is slightly reduced, attached wall
Thrombus sign is reduced as slight.
In vain：Compared with before treatment, various aspects are without improvement.
Three, therapy：
1, the therapy of the 1st group of-the 15 group of traditional Chinese herbal decoction is：One auxiliary takes 3 days, three times a day, 9 days as one therapeutic course；
2, it is carried out according to drug operation instructions for the 16th group.
Four, treatment results：
Efficient=(number of cases of recovering+effective number of cases+effective number of cases)/total case load × 100%
Rehabilitation rate=number of cases of recovering/total case load × 100%
After two courses for the treatment of, clinical observation statistical result is as shown in table 1 below.
The statistical result of 1 test example of table, 1 clinical test
As it can be seen from table 1 after 2 course of therapy, the effective percentage and rehabilitation rate of 1-10 groups are apparently higher than 11-
16 groups of effective percentage and rehabilitation rate.1-5 group bulk pharmaceutical chemicals components are identical, and constituent content difference is little, and efficient and rehabilitation rate is poor
Not not less.The effective percentage and rehabilitation rate of 6-10 groups are all higher than the 5th group, and the 6th group adds bark of ash, earthworm, river compared to the 5th group
Rhizome of chuanxiong；7th group adds rhizoma atractylodis, Cortex Phellodendri, myrrh compared to the 5th group；8th group adds the root of Chinese clematis, pawpaw, madder compared to the 5th group
Grass；9th group of compared to the 5th group addition dandelion, Chinese violet and semiaquilegia adoxoides.The addition of these bulk pharmaceutical chemicals can promote Chinese medicinal decoction of the present invention
The therapeutic effect of agent, the present invention in embodiment 10 traditional Chinese herbal decoction treatment deep vein thrombosis have fine curative effect, by 2 courses for the treatment of
After treatment, treated effect is up to 98% or more, and rehabilitation rate is up to 95% or more.
11-14 groups are compared with the 5th group, are distinguished in bulk pharmaceutical chemicals component：11st group reduces Qiang compared to the 5th group
It is living；12nd group reduces Rhizoma Et Radix Notopterygii and rhizoma cyperi compared to the 5th group；13rd group reduces Rhizoma Et Radix Notopterygii, rhizoma cyperi and five spirits compared to the 5th group
Fat；14th group reduces Rhizoma Et Radix Notopterygii, rhizoma cyperi, excrementum pteropi and the root of three-nerved spicebush compared to the 5th group.15th group compared with the 5th group, each component content
Difference, the 15th group cannot obtain ideal therapeutic effect, and efficient and rehabilitation rate is relatively low.This illustrates Chinese medicinal composition and compatibility content
The performance of drug effect is played a crucial role, if compatibility does not reach requirement, ideal therapeutic effect is not achieved.
In addition, the effective percentage and rehabilitation rate of 1-10 groups are apparently higher than the 16th group, this illustrates the traditional Chinese herbal decoction of the present invention
Therapeutic effect is better than the therapeutic effect of XUESHUANTONG JIAONANG.
Model case：
Case 1
Patient：Tang's boundary, man, 78 years old；
Symptom：Right side deep vein thrombosis causes right lower extremity oedema, difficulty in walking to be treated without apparent within three months through doctor trained in Western medicine anticoagulant therapy
Effect；
Therapeutic effect：On April 9th, 2016 is medical, subsides a swelling after taking this traditional Chinese herbal decoction 6 days, is completely recovered after 9 days.
Case 2
Patient：Week, certain was beautiful, female, 48 years old；
Symptom：Arthralgia 10 years, left lower extremity thromboembolism more than 1 year, left foot multiple ulcer do not recover for a long time；
Therapeutic effect：On November 19th, 2013 is medical, and color ultrasound prompts no blood, takes this traditional Chinese herbal decoction and treats 2 courses for the treatment of
After fully recover.
Case 3
Patient:Zhu's show, female, 78 years old；
Symptom：It swells and ache more than 2 years below left knee joint, left leg varication；
Therapeutic effect：On November 30th, 2013 is medical, and color ultrasound prompts no blood, takes this traditional Chinese herbal decoction and treats 1 course for the treatment of
After fully recover.
Case 4
Patient：Certain pine is paid, it is male, 78 years old；
Symptom：Right lower extremity phlebothrombosis, necrosis, ulcer, flow liquid, color ultrasound prompt no blood；
Therapeutic effect：On April 10th, 2010 is medical, takes after this traditional Chinese herbal decoction treats 2 courses for the treatment of and subsides a swelling, 3 courses for the treatment of are complete
Full rehabilitation.
Case 5
Patient：Poplar is clear, man, 78 years old；
Symptom：Arthralgia more than 1 year, right leg swelling is more than half a year；
Therapeutic effect：On March 12nd, 2014 is medical, takes after this traditional Chinese herbal decoction treats 1 course for the treatment of and fully recovers.
Case 6
Patient：Poplar field, man, 80 years old；
Symptom：Edema of pair of lower extremities, multiple ulcer, maximum ulcer diameter 8cm, hence it is evident that sepage oozing of blood a year and a half, color ultrasound carry
Show no blood；
Therapeutic effect：April 15 in 2016 is medical, takes after this traditional Chinese herbal decoction treats 2 courses for the treatment of and subsides a swelling, complete after 4 courses for the treatment of
Full rehabilitation.
Case 7
Patient：Chen's space, female, 33 years old；
Symptom：Cervical vertebra, lumbar vertebrae hyperosteogeny, double lower limb wood fiber crops, oedema, color ultrasound Ti Shi popliteal phlebothrombosises, no blood image；
Therapeutic effect：January 21 in 2009 is medical, takes 1 course for the treatment of of this traditional Chinese herbal decoction treatment and fully recovers.
Case 8
Patient：Certain cypress is paid, it is male, 70 years old；
Symptom：Cervical syndrome, right lower extremity phlebothrombosis prompt no blood with necrosis, color ultrasound；
Therapeutic effect：October 31 in 2003 is medical, takes after this traditional Chinese herbal decoction treats 9 auxiliaries and fully recovers.
Although illustrate and describing the present invention with specific embodiment, it will be appreciated that without departing substantially from the present invention's
Many other change and modification can be made in the case of spirit and scope.It is, therefore, intended that in the following claims
Including belonging to all such changes and modifications in the scope of the invention.
Claims (10)
1. a kind of Chinese medicine composition of antithrombotic, which is characterized in that include the bulk pharmaceutical chemicals of following parts by weight：10~25 parts of the root of bidentate achyranthes,
5~20 parts of Radix Angelicae Sinensis, 25~40 parts of Radix Astragali, 15~25 parts of peach kernel, 10~25 parts of safflower, 10~20 parts of cassia twig, 12~25 parts of the root of fangji,
5~25 parts of radix paeoniae rubra, 8~30 parts of Radix Salviae Miltiorrhizae, 25~40 parts of Caulis Spatholobi, 12~30 parts of caulis lonicerae, 3~10 parts of ground bettle, Rhizoma Et Radix Notopterygii 3~15
8~16 parts of part, 10~30 parts of rhizoma cyperi, 5~25 parts of excrementum pteropi and the root of three-nerved spicebush.
2. the Chinese medicine composition of antithrombotic described in accordance with the claim 1, which is characterized in that include the raw material of following parts by weight
Medicine：12~22 parts of the root of bidentate achyranthes, 8~18 parts of Radix Angelicae Sinensis, 28~38 parts of Radix Astragali, 17~23 parts of peach kernel, 12~22 parts of safflower, cassia twig 12~18
Part, 14~22 parts of the root of fangji, 8~22 parts of radix paeoniae rubra, 10~26 parts of Radix Salviae Miltiorrhizae, 28~38 parts of Caulis Spatholobi, 14~28 parts of caulis lonicerae, ground bettle
10~15 parts of 4~8 parts, 5~12 parts of Rhizoma Et Radix Notopterygii, 12~28 parts of rhizoma cyperi, 7~22 parts of excrementum pteropi and the root of three-nerved spicebush.
3. the Chinese medicine composition of antithrombotic described in accordance with the claim 1, which is characterized in that include the raw material of following parts by weight
Medicine：15~18 parts of the root of bidentate achyranthes, 12~16 parts of Radix Angelicae Sinensis, 30~35 parts of Radix Astragali, 20~22 parts of peach kernel, 15~20 parts of safflower, cassia twig 14~
16 parts, 16~20 parts of the root of fangji, 12~18 parts of radix paeoniae rubra, 12~22 parts of Radix Salviae Miltiorrhizae, 30~35 parts of Caulis Spatholobi, 18~22 parts of caulis lonicerae, soil
12~14 parts of 5~7 parts of soft-shelled turtle worm, 7~10 parts of Rhizoma Et Radix Notopterygii, 15~25 parts of rhizoma cyperi, 10~18 parts of excrementum pteropi and the root of three-nerved spicebush.
4. according to the Chinese medicine composition of claim 1-3 any one of them antithrombotics, which is characterized in that further include following weight
The bulk pharmaceutical chemicals of part：15~30 parts of bark of ash, 5~20 parts of earthworm, 20~30 parts of Rhizoma Chuanxiong, 15~30 parts of rhizoma atractylodis, 10~20 parts of Cortex Phellodendri and
5~20 parts of myrrh.
5. according to the Chinese medicine composition of claim 1-3 any one of them antithrombotics, which is characterized in that further include following weight
The bulk pharmaceutical chemicals of part：7~15 parts of the root of Chinese clematis, 3~12 parts of pawpaw, 12~20 parts of madder, 20~50 parts of dandelion, 15~40 parts of Chinese violet
With 5~20 parts of semiaquilegia adoxoides.
6. the Chinese medicine composition of antithrombotic described in accordance with the claim 1, which is characterized in that the Chinese medicine composition includes following
The bulk pharmaceutical chemicals of parts by weight：10~25 parts of the root of bidentate achyranthes, 5~20 parts of Radix Angelicae Sinensis, 25~40 parts of Radix Astragali, 15~25 parts of peach kernel, safflower 10~25
Part, 10~20 parts of cassia twig, 12~25 parts of the root of fangji, 5~25 parts of radix paeoniae rubra, 8~30 parts of Radix Salviae Miltiorrhizae, 25~40 parts of Caulis Spatholobi, caulis lonicerae 12
~30 parts, 3~10 parts of ground bettle, 3~15 parts of Rhizoma Et Radix Notopterygii, 10~30 parts of rhizoma cyperi, 5~25 parts of excrementum pteropi, 8~16 parts of the root of three-nerved spicebush, bark of ash
15~30 parts, 5~20 parts of earthworm, 20~30 parts of Rhizoma Chuanxiong, 15~30 parts of rhizoma atractylodis, 10~20 parts of Cortex Phellodendri, 5~20 parts of myrrh, Wheeling
5~20 parts of 7~15 parts celestial, 3~12 parts of pawpaw, 12~20 parts of madder, 20~50 parts of dandelion, 15~40 parts of Chinese violet and semiaquilegia adoxoides.
7. a kind of preparation method of Chinese medicine composition according to claim 1-6 any one of them antithrombotics, which is characterized in that
Include the following steps：
By the root of bidentate achyranthes of formula ratio, Radix Angelicae Sinensis, Radix Astragali, peach kernel, safflower, cassia twig, the root of fangji, radix paeoniae rubra, Radix Salviae Miltiorrhizae, Caulis Spatholobi, caulis lonicerae, ground beetle
Worm, Rhizoma Et Radix Notopterygii, rhizoma cyperi, excrementum pteropi, the root of three-nerved spicebush, optional bark of ash, earthworm, rhizoma atractylodis, Cortex Phellodendri, myrrh, the root of Chinese clematis, pawpaw, madder, Pu Gong
English, Chinese violet and semiaquilegia adoxoides mix after crushing, and obtain the Chinese medicine composition of antithrombotic.
8. a kind of Chinese medicine preparation of antithrombotic, which is characterized in that include the Chinese medicine of claim 1-6 any one of them antithrombotics
Composition and optional auxiliary material：
Preferably, the Chinese medicine preparation of the antithrombotic includes decoction, pulvis, tablet, pill or paste.
9. a kind of preparation method of the Chinese medicine preparation of antithrombotic according to claim 8, which is characterized in that including following step
Suddenly：
(a) by the root of bidentate achyranthes of formula ratio, Radix Angelicae Sinensis, Radix Astragali, peach kernel, safflower, cassia twig, the root of fangji, radix paeoniae rubra, Radix Salviae Miltiorrhizae, Caulis Spatholobi, caulis lonicerae,
Ground bettle, Rhizoma Et Radix Notopterygii, rhizoma cyperi, excrementum pteropi, the root of three-nerved spicebush, optional bark of ash, earthworm, Rhizoma Chuanxiong, rhizoma atractylodis, Cortex Phellodendri, myrrh, the root of Chinese clematis, pawpaw,
Madder, dandelion, Chinese violet and semiaquilegia adoxoides are impregnated 1-3 hours with 30-40 DEG C of water；
(b) 300-600 milliliters of water are added every time into the bulk pharmaceutical chemicals after immersion, after big fire is boiled, warm fire infusion 0.5-3 hours,
Infusion 3-5 times；
(c) after mixing the concoction of gained after each infusion, optionally auxiliary material is added, obtains the traditional Chinese herbal decoction of antithrombotic.
10. a kind of Chinese medicine composition of claim 1-6 any one of them antithrombotics is in the drug for preparing anti embolus disease
Purposes.
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| CN102657754A (en) * | 2012-05-23 | 2012-09-12 | 通化中西医结合血栓病研究所 | Thrombus collaterals-dredging medicament |
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| CN102657754A (en) * | 2012-05-23 | 2012-09-12 | 通化中西医结合血栓病研究所 | Thrombus collaterals-dredging medicament |
| KR20160073167A (en) * | 2014-12-16 | 2016-06-24 | 한국식품연구원 | Composition for enhancing blood circulation containing a lot of acidic polysaccharide in Panax ginseng by high pressure/enzyme dissolution |
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