CN108403531A

CN108403531A - Purposes of the moldavica dragonhead extractive in preparing whitening cosmetics

Info

Publication number: CN108403531A
Application number: CN201810536952.3A
Authority: CN
Inventors: 曾亿格
Original assignee: Individual
Current assignee: Individual
Priority date: 2018-05-30
Filing date: 2018-05-30
Publication date: 2018-08-17

Abstract

The invention discloses a kind of new application of moldavica dragonhead extractive, the new application especially in preparing whitening cosmetics.Normal individual trial test result shows：Subject applies skin using moldavica dragonhead extractive, and L* values, ITA ° of value are in raising trend, and MI values are in reduction trend, illustrate using after moldavica dragonhead extractive, skin color is biased to white and bright variation, and melanin content tends to reduce, therefore can be used for preparing whitening spot-removing class cosmetics.

Description

Purposes of the moldavica dragonhead extractive in preparing whitening cosmetics

Technical field

The purposes that the present invention relates to moldavica dragonhead extractives in preparing cosmetics is especially preparing whitening cosmetics In purposes.

Background technology

Dracocephalum moldavica (Dracocephalum moldavica L.), Labiatae, green Cymbidium annual herb are 22-40 lis high Rice；Taproot is cylindrical, 2-4.5 millimeters of diameter.Dracocephalum moldavica is to use a kind of relatively more extensive medicinal plant in China, it is main at present Medicinal part is cauline leaf, there is clearing lung-heat inducing diaphoresis, the function of cool liver hemostasis can be used for catching a cold, headache and cardio-cerebrovascular diseases Treatment.There is presently no the reports that Dracocephalum moldavica is used for whitening cosmetics.

Invention content

The new application that the object of the present invention is to provide moldavica dragonhead extractives in preparing whitening cosmetics.

Normal individual trial test result shows：Subject applies skin using moldavica dragonhead extractive, during observing 8 weeks Interior, L* values, ITA ° of value are in raising trend, and MI values are in reduction trend, illustrate that skin color is biased to white using after moldavica dragonhead extractive Color and bright variation, melanin content tends to reduce, therefore moldavica dragonhead extractive can be used for preparing whitening spot-removing class cosmetics.

Test result also shows：The ethanol extract whitening spot-removing effect of Dracocephalum moldavica is better than water extract, and 50-70% The whitening spot-removing effect of ethanol extract is best, works fastest.

Specific implementation mode

The present invention is described in detail below by embodiment.

Embodiment 1

The preparation of moldavica dragonhead extractive：The under ground portion of Dracocephalum moldavica is taken, uses water, 30%, 50%, 70%, 90% body respectively The ethyl alcohol heating extraction of product concentration, is condensed into medicinal extract by extracting solution, fine powder is ground into after being dried under reduced pressure, the water for obtaining Dracocephalum moldavica carries Object and 30-90% ethanol extracts are taken, is used as sample 1-5 successively.

2 normal individual trial of embodiment is tested

1. test apparatus

Dermal melanin and ferroheme tester test the main color base melanin of skin, and output result is with melanin Index (melanin index, MI) value indicates.

Multi-functional skin tester and coloration test probe collect the vertical reflected light of skin surface, carry out trichromatic analysis, The L*a*b* system representations of measurement result International Commission on Illumination.

2. volunteer

50 people of subject, -45 years old 20 years old women are divided into 5 groups, every group of 10 people.Volunteer's exclusion condition meets《Makeup Product contact dermatitis diagnostic criteria and treatment principle》It is included in, exclusion criteria.

3. test method

Sample 1-5 made from embodiment 1 is mixed thoroughly with a small amount of glycerine respectively, according to randomly ordered principle, subject is left, Right forearm respectively uses sample application primary daily morning and evening as test block, subject, and service life is 8 weeks.Within test period, Subject does not change daily cleaning custom, but recipient site does not use other any cosmetics.

4. detection method

Detection carries out five times altogether, is divided into using before sample and using l weeks, 2 weeks, 4 weeks and 8 weeks after sample, same weekly Time is paid a return visit, and subject cleans recipient site before detecting, and after the 20-30min that sits quietly, and test equipment pair is used by laboratory technician Recipient site carries out data acquisition.

5. detection data

(1) dermal melanin content MI values：MI values characterize melanin index, principle be specific wavelength under (568nm, 660nm and 880nm) light, impinge upon volume reflection on human skin, melanin content in skin, the numerical value model of MI determined with this It encloses for 0-999, numerical value is bigger, and dermal melanin content is higher.

(2) skin brightness L* values：L* is white balance, and value is bigger, and color is more biased to white, conversely, being biased to black.

(3) ITA ° of value：ITA ° of value is skin subjects type angle, is that (b* is blue yellow chromaticity, and+b is Huang, and-b is with L* and b* It is blue) numerical value of relevant characterization skin brightness.ITA ° of value is bigger, and skin is brighter, conversely, skin is more silent heavy.

Influence of 1 moldavica dragonhead extractive of table to skin brightness L* values

n

0 week

1 week

2 weeks

4 weeks

8 weeks

Sample 1

10

59.7±2.2

59.3±2.0

59.9±2.2

60.9±2.3

61.3±2.3

Sample 2

10

60.2±2.4

61.1±2.3

61.8±2.3

62.5±2.4

63.8±2.4*

Sample 3

10

58.3±2.3

59.1±2.2

60.7±2.4

62.4±2.2*

63.1±2.2*

Sample 4

10

61.4±2.2

62.1±1.8

62.9±2.2

64.4±2.5*

65.9±2.3*

Sample 5

10

61.0±2.5

61.7±2.3

62.1±1.9

63.3±2.4

65.1±2.6*

Note：Compared with before same group of experiment, * P<0.05.

As can be seen from the above results, within experimental period, the skin brightness L* values of subject have raised trend, say Bright moldavica dragonhead extractive can make skin color be biased to white.Wherein, sample 2-5 test the 8th week when, skin brightness L* values and Compared to having significant difference before experiment, illustrate that alcohol extracting thing is more preferable than the effect of water extract；Sample 3 and 4 is in experiment the 4th Zhou Shi, skin brightness L* values are just provided with significant difference compared with before experiment, illustrate that 50-70% ethanol extracts are carried than other Object is taken to work faster, resultant effect is best.

The influence that 2 moldavica dragonhead extractive of table is worth ITA °

n

0 week

1 week

2 weeks

4 weeks

8 weeks

Sample 1

10

36.7±8.2

37.3±8.3

38.1±8.0

38.9±8.2

39.4±8.5

Sample 2

10

37.1±7.9

37.7±8.0

38.5±8.3

39.1±8.5

40.8±8.2

Sample 3

10

36.2±8.0

36.8±8.2

37.7±8.1

38.8±8.3

40.6±8.5*

Sample 4

10

37.3±7.8

38.2±8.2

39.4±8.5

39.9±8.3

41.7±8.1*

Sample 5

10

37.0±8.2

37.5±8.1

38.2±8.3

39.1±8.2

39.8±8.4

Note：Compared with before same group for the treatment of, * P<0.05.

As can be seen from the above results, within experimental period, ITA ° of value of skin brightness of subject has raised trend, Illustrate that moldavica dragonhead extractive can be such that skin brightness increases, wherein 50-70% ethanol extracts effect is best.

Influence of 3 moldavica dragonhead extractive of table to dermal melanin content MI values

n

0 week

1 week

2 weeks

4 weeks

8 weeks

Sample 1

10

235.7±36.3

231.6±35.6

226.6±34.7

220.4±36.9

218.9±38.2

Sample 2

10

236.8±31.7

231.7±38.4

223.3±35.1

216.2±33.5

208.5±35.6

Sample 3

10

238.6±36.1

229.5±38.3

219.4±37.9

206.7±36.5*

198.5±36.9*

Sample 4

10

241.2±37.4

233.9±37.7

227.5±39.2

212.7±36.8*

207.8±37.1*

Sample 5

10

232.1±32.7

228.8±33.9

224.2±34.3

218.4±34.1

212.7±35.6

Note：Compared with before same group for the treatment of, * P<0.05.

As can be seen from the above results, within experimental period, the skin MI values of subject all have a declining tendency, and illustrate perfume (or spice) Green orchid extract can make the reduction of dermal melanin content, therefore have freckle effect, and wherein 50-70% ethanol extracts effect is most It is good.

Claims

1. purposes of the moldavica dragonhead extractive in preparing whitening cosmetics.

2. purposes as described in claim 1, it is characterised in that：The moldavica dragonhead extractive is the ethyl alcohol extraction of Dracocephalum moldavica root Object.

3. purposes as claimed in claim 2, it is characterised in that：The ethyl alcohol is 50-70% ethyl alcohol.