CN108096569A - A kind of lightening compositions and its application containing Flos persicae extract - Google Patents

A kind of lightening compositions and its application containing Flos persicae extract Download PDF

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CN108096569A
CN108096569A CN201810103526.0A CN201810103526A CN108096569A CN 108096569 A CN108096569 A CN 108096569A CN 201810103526 A CN201810103526 A CN 201810103526A CN 108096569 A CN108096569 A CN 108096569A
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extract
composition
skin
flos persicae
compositions containing
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CN108096569B (en
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练旗旗
刘瑞学
冷群英
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Guangdong Bawei Biological Technology Co Ltd
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Guangdong Bawei Biological Technology Co Ltd
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Abstract

The invention discloses a kind of lightening compositions containing Flos persicae extract and its applications, it is intended to provide a kind of activity that can inhibit tyrosinase, reduce the production of melanin, strengthen skin barrier function simultaneously, it supplements the nutrients to skin, improve skin inferior health, so as to achieve the purpose that the composition of whitening spot-removing, technical solution includes following weight parts component：3.6 5.4 parts of monarch drug in a prescription, 2.4 3.2 parts of ministerial drug composition, 1.2 1.8 parts of adjutant composition make 0.8 1.2 parts of drug composition；The monarch drug in a prescription is Flos persicae extract；The ministerial drug composition includes Beauveria sp extract, Saururus chinensis extract and common perilla leaf extract；The adjutant composition includes Viscum album extract and Radix Cynanchi Paniculati extract；Described makes drug composition include Wild soybean seed powder, protease glucan and Mel extract；Belong to technical field of skin care.

Description

A kind of lightening compositions and its application containing Flos persicae extract
Technical field
The invention discloses a kind of lightening compositions, and in particular to a kind of lightening compositions containing Flos persicae extract belong to Technical field of skin care.
Background technology
With the improvement of living standards, the change of the environment residing for people, the fast pace of life, water, diet and air Pollution, the increase of hormone product, the increase of drug contamination and pressure of vegetables and fruit, etc. a series of inferior health life shapes State causes " inferior health " of body, and the inferior health of body can directly result in the appearance of inferior health skin.For medical angle, " inferior health skin " be because various factors causes skin histology underactivity, and between health and it is non-health between a kind of skin Matter.This more Non Apparent Abnormalities of skin, but the metabolism of cell, microcirculation, Water-Electrolyte occur obstacle, skin barrier by Damage, from the point of view of external imagery, it shows dark and gloomy simple and unadorned, improper dry aging, fat secretion is excessively prosperous, the trace of blood occurs and quick Sensitivity increases.This skin quality accounts for the seventy percent of crowd, it belongs to obstruction type skin quality.
For a long time, color spot always a big problem of puzzlement human skin and dermatology and cosmetology is important Problem, although not had much influence to people's health and life, these skin inferior healths are that state but makes many people It is worried.Skin in sub-health state, collagen secretion are reduced, and collagen activity declines, and causes skin obscure It is unglazed.Ultraviolet light, blue light, pollutant for being contacted in daily life etc. can increase TYR enzyme activity, promote melanocyte A large amount of melanin are synthesized, melanin is transported to keratinocyte after generating, and the skin barrier of inferior health skin is not perfect, melanin It is uneven to be deposited in skin surface, cause skin melanin density higher, and also the sluggish metabolism of inferior health skin, black Element cannot exclude in time, just be present with dark and gloomy pigmentation, the colour of skin, long blackspot, chloasma.
Skin care item on the market are set mostly just for single skin problem now, therefore are studied a by adjusting comprehensively Reason skin inferior health, which reaches, lightens the stain the skin care item for playing whitening effect, is the direction solved the problems, such as.
The content of the invention
The object of the present invention is to provide a kind of composition containing Flos persicae extract with whitening effect, in our company In product line, we name it as " whitening peach blossom ball ", and said composition is mainly using Chinese medicine material, the original formed with reference to color spot Cause is designed according to the theory of the traditional Chinese medical science " monarch ", can inhibit the activity of tyrosinase, reduces the production of melanin, Strengthen skin barrier function simultaneously, supplement the nutrients to skin, improve skin inferior health, so as to achieve the purpose that whitening spot-removing.This Invention also provides the application of said composition.
For this purpose, first technical solution that the application provides is such:
A kind of lightening compositions containing Flos persicae extract, including following weight parts component：3.6-5.4 parts of monarch drug in a prescription, ministerial drug group 2.4-3.2 parts of object is closed, 1.2-1.8 parts of adjutant composition makes 0.8-1.2 parts of drug composition；
The monarch drug in a prescription is Flos persicae extract；
The ministerial drug composition includes Beauveria sp extract, Saururus chinensis extract and common perilla leaf extract；
The adjutant composition includes Viscum album extract and Radix Cynanchi Paniculati extract；
Described makes drug composition include Wild soybean seed powder, protease glucan and Mel extract.
Further, a kind of above-mentioned lightening compositions containing Flos persicae extract, the ministerial drug composition further include white Common vetch extract and Semen Persicae extract.
Further, a kind of above-mentioned lightening compositions containing Flos persicae extract, the adjutant composition further include apricot Benevolence extract.
Further, above-mentioned a kind of lightening compositions containing Flos persicae extract, described makes drug composition by Wild soybean Seed powder, protease glucan and Mel extract are according to mass ratio 5-6：2-3：3-4 is formed.
Further, above-mentioned a kind of lightening compositions containing Flos persicae extract, the ministerial drug composition is by muscardine Extract, Saururus chinensis extract, common perilla leaf extract, Radix Cynanchi Atrati extract, Semen Persicae extract are according to mass ratio 3-4：2-3：2- 3：2-3：4-5 is formed.
Further, above-mentioned a kind of lightening compositions containing Flos persicae extract, the adjutant composition is by Ramulus Taxilli Extract, Radix Cynanchi Paniculati extract and apricot seed extract are according to mass ratio 1-2：2-3：4-5 is formed.
Second technical solution provided by the invention is the application of the above-mentioned lightening compositions containing Flos persicae extract.
Compared with prior art, the technical solution that the application provides has following technological merit：
1st, composition of the invention is designed according to the mechanism that theory of traditional Chinese medical science and color spot generate, using Chinese medicine material as master Reasonable composition prescription is wanted, acts synergistically, the activity of tyrosinase can be inhibited, reduce the production of melanin, while strengthen skin Barrier function supplements the nutrients to skin, improves skin inferior health, so as to achieve the purpose that whitening spot-removing.
2nd, the effect of peach blossom is sweet in flavor, pungent, slightly warm in nature, enters the heart, lung, large intestine channel, favourable water, promoting blood circulation, defaecation, happy skin, as Monarch drug in a prescription.Containing the nutriments such as Kaempferol, coumarin, trifolin and vitamin A, B, C in peach blossom, blood vessel can be expanded, is dredged Train of thought, skin of moistening, improves blood circulation, promotes skin-nourishing and oxygen supply, accelerates the lipofuscin element of promotion human senility Excretion, prevents melanin chronic deposition in skin, so as to effectively prevent chloasma, freckle, blackspot.
3rd, the theory converted according to traditional Chinese medical science classification according to manifestation, growth and decline with Bai Zhihei, can use more than white content to treat black It is plain calm；Return the Viscera-State Doctrine of the five internal organs according to the traditional Chinese medical science five colors again, white belongs to lung, and the lung belonging to metal, black category kidney, kidney category water, lung is kidney Mother, according to the theory of " son disease mother control ", it is also possible to white drug therapy melanin pigmentation.Ministerial drug composition root in the present invention Upper theory of traditional Chinese medical science according to this using muscardine, saururus chinensis, common perilla leaf, several traditional Chinese medicine ingredients of radix cynanchi atrati, inhibits the activity of tyrosinase, The pigmentation caused by inflammation is reduced, and Semen Persicae can sterilize moisturizing, nutrition is moistened, and is received containing a variety of amino acid and aliphatic acid Skin, Reduce allergy are held back, more than ingredient compounding assists monarch drug in a prescription to reach better whitening spot-removing effect as ministerial drug.
4th, composition of the invention assists cooperation monarch drug in a prescription, ministerial drug using Ramulus Taxilli, paniculate swallowwort and almond collaboration as adjutant It solves the problems, such as skin pigment, skin barrier function, prevention and resistance dermatitis can also be promoted, reduced since formula components complexity can The allergic phenomena that can be brought.
5th, composition of the invention is strengthened transdermal using honey, Wild soybean seed powder, the combination of protease glucan as medicine is made Function, absorption of the enhancing skin to both effectiveness ingredient monarch drug in a prescription and ministerial drug solve the Transdermal absorption hardly possible that oral traditional Chinese medicine acts on skin Topic, reaches better whitening spot-removing effect.
Specific embodiment
With reference to embodiment, further detailed description in detail is made to the claim of the present invention.
It should be noted that the raw material employed in skill scheme provided by the invention, unless otherwise specified, passes through routine Means are prepared or bought by commercial channel
Flos persicae extract provided by the invention buying in：Huzhou Jiamei Biochemical Products Co., Ltd.；
Ramulus Taxilli (TAXILLUS CHINENSIS) extract buying in：Shaanxi Hao Yang bio tech ltd；
Paniculate swallowwort (CYNANCHUM PANICULATUM) extract buying in：Xi'an Jin Di bio tech ltd；
Apricot seed extract buying in：Guangzhou You Ran bio tech ltd；
Radix cynanchi atrati (AQUILARIA SINENSIS) extract buying in：Shanghai Hui Lang Chemical Co., Ltd.s；
Muscardine (BEAUVERIABASSIANA) extract buying in：Huzhou Jiamei Biochemical Products Co., Ltd.；
Saururus chinensis (SAURURUS CHINENSIS) extract buying in：Increase trade Co., Ltd in Guangzhou；
Peach (PRUNUS PERSICA) kernel extract buying in：Shaanxi Hao Yang bio tech ltd；
Mel extract buying in：Huzhou Jiamei Biochemical Products Co., Ltd..
Embodiment 1
A kind of lightening compositions containing Flos persicae extract provided by the invention, including following weight array point：Monarch drug in a prescription 3.6g, Ministerial drug composition 2.4g, adjutant composition 1.8g, makes drug composition 1.2g；
The monarch drug in a prescription is Flos persicae extract；
The ministerial drug composition is by Beauveria sp extract, Saururus chinensis extract and common perilla leaf extract according to mass ratio 3： 2：3 compositions.
The adjutant composition is by Viscum album extract and Radix Cynanchi Paniculati extract according to mass ratio 1：2 compositions.
Described makes drug composition by Wild soybean seed powder, protease glucan and Mel extract according to mass ratio 5：2：3 Composition.
Embodiment 2
A kind of lightening compositions containing Flos persicae extract provided by the invention, including following weight array point：Monarch drug in a prescription 5.4g, Ministerial drug composition 3.2g, adjutant composition 1.2g, makes drug composition 0.8g；
The monarch drug in a prescription is Flos persicae extract；
The ministerial drug composition is by Beauveria sp extract, Saururus chinensis extract and common perilla leaf extract according to mass ratio 4： 3：3 compositions.
The adjutant composition is by Viscum album extract and Radix Cynanchi Paniculati extract according to mass ratio 2：3 compositions.
Described makes drug composition by Wild soybean seed powder, protease glucan and Mel extract according to mass ratio 6：3：4 Composition.
Embodiment 3
A kind of lightening compositions containing Flos persicae extract provided by the invention, including following weight array point：Monarch drug in a prescription 4g, minister Drug composition 2.5g, adjutant composition 1.6g, makes drug composition 0.9g；
The monarch drug in a prescription is Flos persicae extract；
The ministerial drug composition by Beauveria sp extract, Saururus chinensis extract, common perilla leaf extract, Radix Cynanchi Atrati extract and Semen Persicae extract object is according to mass ratio 3：2：3：2：5 compositions.
The adjutant composition is by Viscum album extract and Radix Cynanchi Paniculati extract according to mass ratio 2：3 compositions.
Described makes drug composition by Wild soybean seed powder, protease glucan and Mel extract according to mass ratio 5.5：3： 3.5 composition.
Embodiment 4
A kind of lightening compositions containing Flos persicae extract provided by the invention, including following weight array point：Monarch drug in a prescription 4g, minister Drug composition 2.8g, adjutant composition 1.5g, makes drug composition 1g；
The monarch drug in a prescription is Flos persicae extract；
The ministerial drug composition is by Beauveria sp extract, Saururus chinensis extract, common perilla leaf extract according to mass ratio 3： 2：2 compositions.
The adjutant composition is by Viscum album extract, Radix Cynanchi Paniculati extract and apricot seed extract according to mass ratio 1.5： 2：4 compositions.
Described makes drug composition by Wild soybean seed powder, protease glucan and Mel extract according to mass ratio 5：3：4 Composition.
Embodiment 5
A kind of lightening compositions containing Flos persicae extract provided by the invention, including following weight component：Monarch drug in a prescription 5g, ministerial drug Composition 3g, adjutant composition 1.7g, makes drug composition 1g；
The monarch drug in a prescription is Flos persicae extract；
The ministerial drug composition by Beauveria sp extract, Saururus chinensis extract, common perilla leaf extract, Radix Cynanchi Atrati extract, Semen Persicae extract is according to mass ratio 4：3：2：3：4 compositions.
The adjutant composition is by Viscum album extract, Radix Cynanchi Paniculati extract and apricot seed extract according to mass ratio 2：3： 5 compositions.
Described makes drug composition by Wild soybean seed powder, protease glucan and Mel extract according to mass ratio 5：2.5： 4 compositions.
The preparation method of the present composition is：In advance by ministerial drug composition, adjutant composition, make drug composition according to rule Determine mass ratio to be pre-mixed the monarch drug in a prescription for uniformly then weighing the parts by weight, ministerial drug composition, adjutant composition, combine medicine Object is added in after suitable deionized water stirs evenly to obtain the final product.
When any one group of lightening compositions containing Flos persicae extract are as skin-care product additive in embodiment 1 to 5, addition Amount accounts for the 0.1-10%, preferably 1-7% of skin care item gross mass.The composition of the present invention is now with the current optimal when specifically used, After the composition for preparing the present invention, it is added to immediately available as skin-care product additive in corresponding skin care item matrix.
In order to more preferably illustrate the effect of the present invention, the comparison of experimental program of the present invention in R＆D process is given below Example.
Comparative example 1
A kind of lightening compositions containing Flos persicae extract that this comparative example provides, including following weight component：Monarch drug in a prescription 5g, minister Medicine 3g, adjutant 1.7g make medicine 1g；
The monarch drug in a prescription is by Beauveria sp extract, Saururus chinensis extract, common perilla leaf extract, Radix Cynanchi Atrati extract, Semen Persicae Extract is according to mass ratio 4：3：2：3：4 compositions；
The ministerial drug is Flos persicae extract.
The adjutant composition is by Viscum album extract, Radix Cynanchi Paniculati extract and apricot seed extract according to mass ratio 2：3： 5 compositions.
Described makes medicine by Wild soybean seed powder, protease glucan and Mel extract according to mass ratio 5：2.5：4 compositions.
Comparative example 2
A kind of lightening compositions containing Flos persicae extract that this comparative example provides, including following weight component：Monarch drug in a prescription 5g, minister Medicine 3g, adjutant 1.7g make medicine 1g；
The monarch drug in a prescription is by Viscum album extract, Radix Cynanchi Paniculati extract and apricot seed extract according to mass ratio 2：3：5 compositions.
The ministerial drug is by Beauveria sp extract, Saururus chinensis extract, common perilla leaf extract according to mass ratio 3：2：2 groups Into.
The adjutant is Flos persicae extract.
Described makes medicine by Wild soybean seed powder, protease glucan and Mel extract according to mass ratio 5：2.5：4 compositions.
Comparative example 3
A kind of lightening compositions containing Flos persicae extract that this comparative example provides, including following weight component：Monarch drug in a prescription 5g, minister Medicine 3g, adjutant 1.7g make medicine 1g；
The monarch drug in a prescription is by Wild soybean seed powder, protease glucan and Mel extract according to mass ratio 5：2.5：4 compositions；
The ministerial drug is by Beauveria sp extract, Saururus chinensis extract, common perilla leaf extract, Radix Cynanchi Atrati extract, Semen Persicae Extract is according to mass ratio 4：3：2：3：4 compositions.
The adjutant is by Viscum album extract, Radix Cynanchi Paniculati extract and apricot seed extract according to mass ratio 2：3：5 compositions.
Described makes medicine Flos persicae extract.
Comparison 4
The protease glucan made in drug composition in embodiment 5 is removed, other materials are constant with content；
Comparison 5
Viscum album extract in adjutant composition in embodiment 5 is substituted with Radix Cynanchi Paniculati extract, other contents are not Become.
Comparative example 6
The middle Beauveria sp extract of ministerial drug composition in embodiment 5 is substituted with Saururus chinensis extract, other contents are not Become.
Comparative example 7
The middle Saururus chinensis extract of ministerial drug composition in embodiment 5, common perilla leaf extract are replaced with Beauveria sp extract Generation, other contents are constant.
The lightening compositions containing Flos persicae extract of the application offer and its experimental data of contrast experiment are provided.
Experimental example 1
Experimental principle
The variation of skin color can be measured using skin complexion measuring instrument.The quantization skin generally used at present The measuring method of color is that colorimeter system (Lab colorimeter systems) measures skin color as defined in International Commission on Illumination (CIE) Variation, the method quantify it is more accurate, can reflect the variation of skin color Spatial Multi-Dimensional, the quantization for making the colour of skin is more reliable.Test Index is dermal melanin content MI values (measured value is higher, illustrates that melanin content is higher in skin), skin whiteness brightness (L values characterization L* is white balance, and value is bigger, and color is more inclined to white for L values and ITA °；ITA ° of value is skin subjects type angle, ITA ° Value is bigger, and skin is brighter).Thus cosmetics can be judged by measuring keratoderma melanin content, skin colourity Whitening effect.
△ MI=Tn-T0；T in formulanNumerical value is changed over time for tested region；T0For tested region initial value.
△ L*=Tn-T0；T in formulanNumerical value is changed over time for tested region；T0For tested region initial value.
△ ITA °=Tn-T0；T in formulanNumerical value is changed over time for tested region；T0For tested region initial value.
Laboratory apparatus
Multi-functional skin test system (MPA580, German CK)；
Skin aberration test probe and (CL400, German CK)；
Skin red and black pigment tester and test probe (Mexameter MX18, German CK).
Experimental method
The more dim adult 120 of blee is screened, is randomly divided into 12 groups, every group 10 are used as trier, try out Melanin is carried out to its skin of face before sample and chromatism data collection analysis is tested, data are as skin background values.Trier Sooner or later respectively it is used continuously 4 weeks using a sample.Data acquisition was carried out when the 1st week, the 2nd week, the 4th week.It evaluates and tests tested Person uses skin whiteness (brightness) and the variation of dermal melanin content before and after cosmetics, so that it is determined that the whitening effect of cosmetics Fruit.
Laboratory sample
The composition of embodiment 1-5, comparative example 1-7 are added in face cream matrix, embodiment face cream 1-6, comparative example is made The additive amount of face cream 1-7, wherein composition in face cream is 7%.Control group is face cream matrix.
Experimental result is shown in Table 1 to 3.
1 product of table uses front and rear dermal melanin MI value test results
As it can be seen from table 1 after using face cream prepared by the composition of the present invention, dermal melanin MI values reduce, and say The composition of the bright present invention has the effect for reducing dermal melanin, wherein can make the reduction of MI values using 5 face cream of embodiment 21.34, effect is more apparent.
2 product of table uses front and rear skin lightness L* Data-Statistics results
From table 2 it can be seen that within 4 weeks test periods, after face cream of the subject using the composition preparation of the present invention, skin Skin lightness L* values raise, and illustrate the composition of the present invention and have the effect for improving skin whiteness.
3 product of table uses front and rear ITA ° of Data-Statistics result of skin lightness
As can be seen from Table 3, within 4 weeks test periods, after face cream of the subject using the composition preparation of the present invention, skin ITA ° of value rise of skin lightness, illustrates the combination of the present invention with the effect for improving skin lightness.
Above-described embodiment is the preferable embodiment of the present invention, but embodiments of the present invention and from above-described embodiment Limitation, other any Spirit Essences without departing from the present invention with made under principle change, modification, replacement, combine, simplification, Equivalent substitute mode is should be, is included within protection scope of the present invention.

Claims (7)

1. a kind of lightening compositions containing Flos persicae extract, which is characterized in that including following weight parts component：Monarch drug in a prescription 3.6-5.4 Part, 2.4-3.2 parts of ministerial drug composition, 1.2-1.8 parts of adjutant composition makes 0.8-1.2 parts of drug composition；
The monarch drug in a prescription is Flos persicae extract；
The ministerial drug composition includes Beauveria sp extract, Saururus chinensis extract and common perilla leaf extract；
The adjutant composition includes Viscum album extract and Radix Cynanchi Paniculati extract；
Described makes drug composition include Wild soybean seed powder, protease glucan and Mel extract.
A kind of 2. lightening compositions containing Flos persicae extract according to claim 1, which is characterized in that the ministerial drug group It closes object and further includes Radix Cynanchi Atrati extract and Semen Persicae extract.
A kind of 3. lightening compositions containing Flos persicae extract according to claim 1, which is characterized in that the adjutant group It closes object and further includes apricot seed extract.
4. a kind of lightening compositions containing Flos persicae extract according to claim 1, which is characterized in that described makes medicine group Object is closed by Wild soybean seed powder, protease glucan and Mel extract according to mass ratio 5-6：2-3：3-4 is formed.
A kind of 5. lightening compositions containing Flos persicae extract according to claim 2, which is characterized in that the ministerial drug group Object is closed by Beauveria sp extract, Saururus chinensis extract, common perilla leaf extract, Radix Cynanchi Atrati extract, Semen Persicae extract according to quality Compare 3-4：2-3：2-3：2-3：4-5 is formed.
A kind of 6. lightening compositions containing Flos persicae extract according to claim 3, which is characterized in that the adjutant group Object is closed by Viscum album extract, Radix Cynanchi Paniculati extract and apricot seed extract according to mass ratio 1-2：2-3：4-5 is formed.
7. a kind of any lightening compositions containing Flos persicae extract of claim 1 to 6 answering as skin-care product additive With.
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