CN108096569B - Whitening composition containing peach blossom extract and application thereof - Google Patents

Whitening composition containing peach blossom extract and application thereof Download PDF

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CN108096569B
CN108096569B CN201810103526.0A CN201810103526A CN108096569B CN 108096569 B CN108096569 B CN 108096569B CN 201810103526 A CN201810103526 A CN 201810103526A CN 108096569 B CN108096569 B CN 108096569B
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composition
skin
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drug
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CN108096569A (en
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练旗旗
刘瑞学
冷群英
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Guangdong Bawei Biotechnology Co ltd
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Guangdong Bawei Biotechnology Co ltd
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Abstract

The invention discloses a whitening composition containing a peach blossom extract and application thereof, aiming at providing a composition which can inhibit the activity of tyrosinase, reduce the production of melanin, strengthen the barrier function of skin, supplement nutrition for the skin and improve the sub-health of the skin so as to achieve the purpose of whitening and removing freckles, and the technical scheme comprises the following components in parts by weight: 3.6-5.4 parts of monarch drug, 2.4-3.2 parts of ministerial drug composition, 1.2-1.8 parts of adjuvant drug composition and 0.8-1.2 parts of messenger drug composition; the monarch drug is peach blossom extract; the ministerial drug composition comprises beauveria bassiana extract, saururus chinensis extract and perilla frutescens leaf extract; the adjuvant composition comprises a parasitic loranthus extract and a cynanchum paniculatum extract; the said medicinal composition comprises semen glycines powder, protease dextran and Mel extract; belongs to the technical field of skin care products.

Description

Whitening composition containing peach blossom extract and application thereof
Technical Field
The invention discloses a whitening composition, particularly relates to a whitening composition containing a peach blossom extract, and belongs to the technical field of skin care products.
Background
With the improvement of living standard, the change of the environment where people are located, the fast pace of life, the pollution of water, diet and air, the increase of hormone products, the medicine pollution and the pressure increase of vegetables and fruits, and the like, a series of sub-health living states cause the sub-health of the body, and the sub-health of the body can directly cause the appearance of the sub-health skin. From a medical point of view, "sub-healthy skin" is a type of skin that is hypofunctional in skin tissue due to various factors and is between healthy and unhealthy. Although there are no obvious abnormalities in the skin, the metabolism of cells, microcirculation, aqueous electrolyte barrier and skin barrier are damaged, and from the external appearance, it shows tarnish and lusterless, abnormal dry aging, excessive secretion of oil and fat, appearance of blood streak and increased sensitivity. The skin is seven-fold of people and belongs to barrier type skin.
Although not too much influence on human health and life, the sub-health of the skin is a state of much distress. In skin in a sub-healthy state, collagen secretion is reduced, and collagen activity is decreased, resulting in dull skin. Ultraviolet rays, blue light, pollutants and the like which are contacted in daily life can increase the activity of the tyrosinase, promote the melanocyte to synthesize a large amount of melanin, and transport the melanin to keratinocytes after being generated, so that the skin barrier of sub-healthy skin is imperfect, the melanin is unevenly accumulated on the surface of the skin, the density of the melanin of the skin is high, the metabolism of the sub-healthy skin is slow, and the melanin cannot be removed in time, and pigmentation, dark complexion, long black spots and chloasma can be generated.
Most of skin care products on the market are only designed for solving the problem of single skin, so that the research on the skin care product which can lighten color spots and has a whitening effect by comprehensively conditioning the sub-health of the skin is one direction for solving the problem.
Disclosure of Invention
The invention aims to provide a composition containing peach blossom extract with whitening and freckle removing effects, which is named as whitening peach blossom pills in a product series of the company, is mainly prepared from traditional Chinese medicine raw materials, is designed according to the theory of monarch, minister, assistant and guide in traditional Chinese medicine by combining the reason of color spot formation, can inhibit the activity of tyrosinase, reduce the production of melanin, simultaneously strengthen the skin barrier function, supplement nutrition to the skin, and improve the sub-health of the skin, thereby achieving the purpose of whitening and removing freckles. The invention also provides the application of the composition.
Therefore, the first technical scheme provided by the application is as follows:
a whitening composition containing a peach blossom extract comprises the following components in parts by weight: 3.6-5.4 parts of monarch drug, 2.4-3.2 parts of ministerial drug composition, 1.2-1.8 parts of adjuvant drug composition and 0.8-1.2 parts of messenger drug composition;
the monarch drug is peach blossom extract;
the ministerial drug composition comprises beauveria bassiana extract, saururus chinensis extract and perilla frutescens leaf extract;
the adjuvant composition comprises a parasitic loranthus extract and a cynanchum paniculatum extract;
the said composition comprises semen glycines seed powder, protease dextran and Mel extract.
Furthermore, the whitening composition containing the peach blossom extract further comprises the cynanchum atratum extract and the peach kernel extract.
Furthermore, the above mentioned whitening composition containing peach blossom extract, the adjuvant composition also includes almond extract.
Further, the whitening composition containing the peach blossom extract is prepared from the wild soybean seed powder, the protease glucan and the honey extract according to the mass ratio of 5-6: 2-3: 3-4.
Further, the whitening composition containing the peach blossom extract is prepared from beauveria bassiana extract, saururus chinensis extract, perilla frutescens leaf extract, cynanchum atratum extract and walnut kernel extract according to the mass ratio of 3-4: 2-3: 2-3: 2-3: 4-5.
Furthermore, the adjuvant drug composition of the whitening composition containing the peach blossom extract is prepared from a parasitic loranthus extract, a cynanchum paniculatum extract and an almond extract according to a mass ratio of 1-2: 2-3: 4-5.
The second technical scheme provided by the invention is the application of the whitening composition containing the peach blossom extract.
Compared with the prior art, the technical scheme provided by the application has the following technical advantages:
1. the composition is designed according to the theory of traditional Chinese medicine and the mechanism of color spot generation, adopts the traditional Chinese medicine raw materials as the main components, has reasonable formula and synergistic effect, can inhibit the activity of tyrosinase, reduce the production of melanin, strengthen the barrier function of skin, supplement nutrition for the skin, and improve the sub-health of the skin, thereby achieving the purposes of whitening and removing the spots.
2. Peach blossom is sweet and pungent in flavor, slightly warm in nature, enters heart, lung and large intestine channels, has the effects of promoting diuresis, activating blood circulation, relaxing bowels and nourishing skin, and is used as a monarch drug. The peach blossom contains nutrient substances such as kaempferol, coumarins, trifolioside, vitamin A, B, C and the like, can expand blood vessels, dredge veins, moisten skin, improve blood circulation, promote skin nutrition and oxygen supply, accelerate excretion of lipofuscin for promoting human aging, prevent melanin from being deposited in the skin in a chronic manner, and can effectively prevent chloasma, freckles and black spots.
3. Based on the theory of Chinese medicine of getting elephant and promoting digestion and transformation, the white component can be used for treating melanin deposition; according to the zang-image theory of five colors in five zang organs in traditional Chinese medicine, white belongs to the lung, the lung belongs to the metal, black belongs to the kidney, the kidney belongs to the water, and the lung is the mother of the kidney, and according to the theory of 'mother of child disease' treatment, the white medicine can also be used for treating the melanin pigmentation. According to the theory of traditional Chinese medicine, the ministerial medicine composition adopts several traditional Chinese medicine components of beauveria bassiana, saururus chinensis, perilla frutescens leaves and cynanchum atratum to inhibit the activity of tyrosinase and reduce pigmentation caused by inflammation, the walnut kernel contains various amino acids and fatty acids, can sterilize and moisturize, nourish and moisten, astringe skin and relieve allergy, and the components are compounded to serve as the ministerial medicine to assist the monarch medicine in achieving a better whitening and freckle removing effect.
4. The composition provided by the invention adopts the synergy of the loranthus parasiticus, the cynanchum paniculatum and the almond as adjuvant drugs, assists in matching with monarch drugs and ministerial drugs to solve the skin pigment problem, can also improve the skin barrier function, prevent and resist dermatitis, and reduce the possible allergy phenomenon caused by complex formula components.
5. The composition provided by the invention adopts the combination of honey, wild soybean seed powder and protease glucan as a messenger drug, so that the transdermal function is enhanced, the absorption of the skin to effective components of monarch drugs and ministerial drugs is enhanced, the problem of transdermal absorption of oral traditional Chinese medicines acting on the skin is solved, and the better whitening and freckle removing effects are achieved.
Detailed Description
The claims of the present invention will be described in further detail with reference to the following detailed description.
It should be noted that the raw materials used in the technical scheme provided by the invention are prepared by conventional means or purchased from commercial sources except for special instructions
The peach blossom extract provided by the invention is purchased from: camu cami biochemicals, inc;
the extract of Loranthus mulberry mistletoe (Taxillus CHINENSIS) was purchased from: shanxi Haoyang Biotech Co., Ltd;
the extract of Cynanchum PANICULATUM (Cynanchum PANICULATUM) is obtained from: bioscience and technology, west ampere, gold, ltd;
the almond extract was purchased from: guangzhou Youran Biotechnology, Inc.;
cynanchum atratum (Aquilaria SINENSIS) extract was purchased from: shanghai Huilan chemical Co., Ltd;
beauveria bassiana (Beauveriabassiana) extract was purchased from: camu cami biochemicals, inc;
saururi herba (Saururus CHINENSIS) extract was purchased from: guangzhou Gancao trade company;
extracts of the kernel of peach (PRUNUS PERSICA) were purchased from: shanxi Haoyang Biotech Co., Ltd;
the honey extract was purchased from: camei biochemicals, inc.
Example 1
The invention provides a whitening composition containing a peach blossom extract, which comprises the following components in parts by weight: 3.6g of monarch drug, 2.4g of ministerial drug composition, 1.8g of adjuvant drug composition and 1.2g of messenger drug composition;
the monarch drug is peach blossom extract;
the ministerial drug composition is prepared from beauveria bassiana extract, saururus chinensis extract and perilla frutescens leaf extract according to the mass ratio of 3: 2: 3, and (3).
The adjuvant drug composition is prepared from a parasitic loranthus extract and a cynanchum paniculatum extract according to a mass ratio of 1: 2.
The messenger medicine composition is prepared from wild soybean seed powder, protease glucan and honey extract according to a mass ratio of 5: 2: 3, and (3).
Example 2
The invention provides a whitening composition containing a peach blossom extract, which comprises the following components in parts by weight: 5.4g of monarch drug, 3.2g of ministerial drug composition, 1.2g of adjuvant drug composition and 0.8g of messenger drug composition;
the monarch drug is peach blossom extract;
the ministerial drug composition is prepared from beauveria bassiana extract, saururus chinensis extract and perilla frutescens leaf extract according to a mass ratio of 4: 3: 3, and (3).
The adjuvant drug composition is prepared from a parasitic loranthus extract and a cynanchum paniculatum extract according to a mass ratio of 2: 3, and (3).
The messenger medicine composition is prepared from wild soybean seed powder, protease glucan and honey extract according to a mass ratio of 6: 3: 4.
Example 3
The invention provides a whitening composition containing a peach blossom extract, which comprises the following components in parts by weight: 4g of monarch drug, 2.5g of ministerial drug composition, 1.6g of adjuvant drug composition and 0.9g of messenger drug composition;
the monarch drug is peach blossom extract;
the ministerial drug composition is prepared from beauveria bassiana extract, saururus chinensis extract, perilla frutescens leaf extract, cynanchum atratum extract and peach kernel extract according to the mass ratio of 3: 2: 3: 2: 5.
The adjuvant drug composition is prepared from a parasitic loranthus extract and a cynanchum paniculatum extract according to a mass ratio of 2: 3, and (3).
The messenger medicine composition is prepared from wild soybean seed powder, protease glucan and honey extract according to a mass ratio of 5.5: 3: 3.5.
Example 4
The invention provides a whitening composition containing a peach blossom extract, which comprises the following components in parts by weight: 4g of monarch drug, 2.8g of ministerial drug composition, 1.5g of adjuvant drug composition and 1g of messenger drug composition;
the monarch drug is peach blossom extract;
the ministerial drug composition is prepared from beauveria bassiana extract, saururus chinensis extract and perilla frutescens leaf extract according to the mass ratio of 3: 2: 2.
The adjuvant drug composition is prepared from a parasitic loranthus extract, a cynanchum paniculatum extract and an almond extract according to a mass ratio of 1.5: 2: 4.
The messenger medicine composition is prepared from wild soybean seed powder, protease glucan and honey extract according to a mass ratio of 5: 3: 4.
Example 5
The invention provides a whitening composition containing a peach blossom extract, which comprises the following components in parts by weight: 5g of monarch drug, 3g of ministerial drug composition, 1.7g of adjuvant drug composition and 1g of messenger drug composition;
the monarch drug is peach blossom extract;
the ministerial drug composition is prepared from beauveria bassiana extract, saururus chinensis extract, perilla frutescens leaf extract, cynanchum atratum extract and walnut kernel extract according to the mass ratio of 4: 3: 2: 3: 4.
The adjuvant drug composition is prepared from a parasitic loranthus extract, a cynanchum paniculatum extract and an almond extract according to a mass ratio of 2: 3: 5.
The messenger medicine composition is prepared from wild soybean seed powder, protease glucan and honey extract according to a mass ratio of 5: 2.5: 4.
The preparation method of the composition comprises the following steps: the ministerial drug composition, the adjuvant drug composition and the messenger drug composition are mixed uniformly in advance according to the specified mass ratio, and then the monarch drug, the ministerial drug composition, the adjuvant drug composition and the messenger drug composition in parts by weight are weighed, added with a proper amount of deionized water and stirred uniformly to obtain the composition.
When the whitening composition containing the peach blossom extract in any one of examples 1 to 5 is used as a skin care product additive, the addition amount of the whitening composition is 0.1 to 10 percent of the total mass of the skin care product, and the addition amount is preferably 1 to 7 percent. The composition of the invention is best used when being prepared in a specific use mode, namely the composition is added into a corresponding skin care product matrix as a skin care product additive immediately after being prepared.
To better illustrate the effects of the present invention, comparative examples of experimental protocols of the present invention during development are given below.
Comparative example 1
The whitening composition containing the peach blossom extract comprises the following components in parts by weight: 5g of monarch drug, 3g of ministerial drug, 1.7g of adjuvant drug and 1g of messenger drug;
the monarch drug is prepared from a beauveria bassiana extract, a saururus chinensis extract, a perilla frutescens leaf extract, a cynanchum atratum extract and a walnut kernel extract according to a mass ratio of 4: 3: 2: 3: 4, preparing a composition;
the ministerial drug is peach blossom extract.
The adjuvant drug composition is prepared from a parasitic loranthus extract, a cynanchum paniculatum extract and an almond extract according to a mass ratio of 2: 3: 5.
The guiding drug is prepared from wild soybean seed powder, protease glucan and honey extract according to a mass ratio of 5: 2.5: 4.
Comparative example 2
The whitening composition containing the peach blossom extract comprises the following components in parts by weight: 5g of monarch drug, 3g of ministerial drug, 1.7g of adjuvant drug and 1g of messenger drug;
the monarch drug is prepared from a parasitic loranthus extract, a cynanchum paniculatum extract and an almond extract according to a mass ratio of 2: 3: 5.
The ministerial drug is prepared from beauveria bassiana extract, saururus chinensis extract and perilla frutescens leaf extract according to the mass ratio of 3: 2: 2.
The adjuvant drug is peach blossom extract.
The guiding drug is prepared from wild soybean seed powder, protease glucan and honey extract according to a mass ratio of 5: 2.5: 4.
Comparative example 3
The whitening composition containing the peach blossom extract comprises the following components in parts by weight: 5g of monarch drug, 3g of ministerial drug, 1.7g of adjuvant drug and 1g of messenger drug;
the monarch drug is prepared from wild soybean seed powder, protease glucan and honey extract according to a mass ratio of 5: 2.5: 4, preparing a composition;
the ministerial drug is prepared from beauveria bassiana extract, saururus chinensis extract, perilla frutescens leaf extract, cynanchum atratum extract and walnut kernel extract according to the mass ratio of 4: 3: 2: 3: 4.
The adjuvant is prepared from a parasitic loranthus extract, a cynanchum paniculatum extract and an almond extract according to a mass ratio of 2: 3: 5.
The peach blossom extract is prepared from peach blossom.
Comparative example 4
The protease glucan in the medicinal composition in the embodiment 5 is removed, and other substances and contents are unchanged;
comparative example 5
The extract of loranthus parasiticus in the adjuvant composition in example 5 was replaced with the extract of cynanchum paniculatum, and the other contents were unchanged.
Comparative example 6
The beauveria bassiana extract in the ministerial drug composition in example 5 is replaced by the saururus chinensis extract, and other contents are unchanged.
Comparative example 7
The saururus chinensis extract and the perilla leaf extract in the ministerial drug composition in the example 5 are replaced by the beauveria bassiana extract, and other contents are unchanged.
Experimental data of the whitening composition containing the peach flower extract provided in the present application and comparative experiments thereof are given below.
Experimental example 1
Principle of experiment
The change in skin color can be measured using a skin complexion measuring instrument. The currently widely adopted measuring method for quantifying skin color is to measure the change of skin color by a colorimetric system (Lab colorimetric system) specified by the International Commission on illumination (CIE), and the method has accurate quantification, can reflect the multidimensional change of a skin color space, and ensures that the skin color is quantified more reliably. The test indexes are the MI value of the skin melanin content (the higher the measured value is, the higher the melanin content in the skin is), the L value of the skin whiteness/brightness and the ITA degree (the L value indicates that L is white balance, the larger the value is, the more white the color is, the ITA degree value is the individual type angle of the skin, and the larger the ITA degree value is, the brighter the skin). Therefore, the whitening effect of the cosmetic can be judged by measuring the melanin content of the skin stratum corneum and the skin chromaticity.
△MI＝Tn-T0(ii) a In the formula TnThe time-varying value of the tested area; t is0Is the initial value of the tested area.
△L*＝Tn-T0(ii) a In the formula TnThe time-varying value of the tested area; t is0Is the initial value of the tested area.
△ITA°＝Tn-T0(ii) a In the formula TnThe time-varying value of the tested area; t is0Is the initial value of the tested area.
Laboratory apparatus
Multifunctional skin test system (MPA580, CK, germany);
skin color difference test probe and (CL400, CK, germany);
skin red melanin tester and test probe (Mexameter MX18, CK, germany).
Experimental methods
120 adults with dull facial skin color are screened, the adults are randomly divided into 12 groups, 10 adults in each group are used as test persons, the facial skin is subjected to melanin and color difference data acquisition, analysis and test before the samples are tried, and the data are used as skin background values. The sample was used once in the morning and at night for 4 weeks. Data collection was performed at week 1, week 2, and week 4, respectively. The change of skin whiteness (brightness) and skin melanin content before and after the application of the cosmetics to the subject was evaluated, thereby determining the whitening effect of the cosmetics.
Experimental sample
The compositions of examples 1-5 and comparative examples 1-7 were added to a cream base to make example creams 1-6 and comparative creams 1-7, wherein the composition was added in an amount of 7% in the cream. The control group was cream base.
The results are shown in tables 1 to 3.
TABLE 1 results of MI value test of skin melanin before and after using the product
Figure BDA0001567126370000071
Figure BDA0001567126370000081
As can be seen from Table 1, the MI value of the skin melanin is reduced after the cream prepared by using the composition of the invention, which shows that the composition of the invention has the effect of reducing the skin melanin, wherein the MI value can be reduced by 21.34 by using the cream of example 5, and the effect is obvious.
TABLE 2 statistical results of skin brightness L before and after application of the product
Figure BDA0001567126370000082
As can be seen from table 2, the skin brightness L value increased after the subject used the cream prepared from the composition of the present invention within 4 weeks of the test cycle, indicating that the composition of the present invention has the effect of increasing skin whiteness.
TABLE 3 statistical results of ITA DEG values of skin brightness before and after application of the product
Figure BDA0001567126370000091
As can be seen from table 3, the skin brightness ITA ° value increased after the subjects used the cream prepared with the composition of the present invention within 4 weeks of the test period, indicating that the combination of the present invention has the effect of increasing skin brightness.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.

Claims (2)

1. The whitening composition containing the peach blossom extract is characterized by comprising the following components in parts by weight: 3.6-5.4 parts of monarch drug, 2.4-3.2 parts of ministerial drug composition, 1.2-1.8 parts of adjuvant drug composition and 0.8-1.2 parts of messenger drug composition;
the monarch drug is peach blossom extract;
the ministerial drug composition is prepared from beauveria bassiana extract, saururus chinensis extract, perilla frutescens leaf extract, cynanchum atratum extract and walnut kernel extract according to the mass ratio of 3-4: 2-3: 2-3: 4-5;
the adjuvant composition consists of a parasitic loranthus extract, a cynanchum paniculatum extract and an almond extract according to the mass ratio of 1-2: 2-3: 4-5;
the messenger medicine composition consists of wild soybean seed powder, protease glucan and honey extract according to the mass ratio of 5-6: 2-3: 3-4.
2. The use of the peach blossom extract-containing whitening composition according to claim 1 as a skin care product additive.
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CN102429852A (en) * 2012-01-01 2012-05-02 杨军 Preparation method for processing freckle-removing beauty ultrafine powder from peach flower
CN107536724A (en) * 2017-08-25 2018-01-05 漳浦彩露华化妆品有限公司 A kind of former skin water and preparation method thereof

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CN102429852A (en) * 2012-01-01 2012-05-02 杨军 Preparation method for processing freckle-removing beauty ultrafine powder from peach flower
CN107536724A (en) * 2017-08-25 2018-01-05 漳浦彩露华化妆品有限公司 A kind of former skin water and preparation method thereof

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