CN108379322A - A kind of preparation method of Huang olive mouth-keeping tablet for reliving sore-throat - Google Patents

A kind of preparation method of Huang olive mouth-keeping tablet for reliving sore-throat Download PDF

Info

Publication number
CN108379322A
CN108379322A CN201810131746.4A CN201810131746A CN108379322A CN 108379322 A CN108379322 A CN 108379322A CN 201810131746 A CN201810131746 A CN 201810131746A CN 108379322 A CN108379322 A CN 108379322A
Authority
CN
China
Prior art keywords
olive
mouth
throat
extraction
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810131746.4A
Other languages
Chinese (zh)
Inventor
张玲
李春海
卢斯锴
黄健文
刘珊妮
李雯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guangdong University of Petrochemical Technology
Original Assignee
Guangdong University of Petrochemical Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guangdong University of Petrochemical Technology filed Critical Guangdong University of Petrochemical Technology
Priority to CN201810131746.4A priority Critical patent/CN108379322A/en
Publication of CN108379322A publication Critical patent/CN108379322A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Otolaryngology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

A kind of preparation method of Huang olive mouth-keeping tablet for reliving sore-throat, the preparation method include making emblica powder, making olive medicinal extract, making olive essential oil and olive mouth-keeping tablet for reliving sore-throat to make.It is extensive that the present invention prepares lozenge raw material sources, cheap, simple for process, and the typical good, delicate mouthfeel of olive buccal tablet flavor obtained has good market prospects.

Description

A kind of preparation method of Huang olive mouth-keeping tablet for reliving sore-throat
Technical field
The present invention relates to a kind of preparation methods of yellow olive mouth-keeping tablet for reliving sore-throat, belong to health product technology field.
Background technology
Lozenge refers to being chiefly used in oral cavity and throat illness contained in the compressed tablets slowly dissolved in oral cavity, and when use is contained in mouth Chamber or cheek, drug have the effects that topical anti-inflammatory, sterilization, convergence, analgesic, and energy by sublingual and oral cavity buccal surface mucosa absorption More long drug effect is locally generated to oral cavity and throat etc..Lozenge hardness is generally large, and mouthfeel is suitable, rapid-action, convenient to take, makes It is wide with crowd.
Olive Canarium album (hour.) Rauesch, alias Chinese olive, main product Fujian are a kind of conventional Chinese medicine Material, quilt《Chinese Pharmacopoeia》It records.Olive complex chemical composition, mainly contain flavone compound, coumarin and phenolic compound, The chemical compositions such as volatile materials, triterpene compound.With loguat leaf, sanchi leaf, the leaf of bamboo, ginkgo leaf, Leaves of Glycyrrhiza Uralensis Fisch, Ilex latifolia tea-leaf Etc. various plants compare, olive general flavone content be in it is above the average, have certain value of exploiting and utilizing.It is reported that olive Fruit is rich in total phenol, content up to 280.46 mg GAE/g (in terms of dry mass), 1,1- diphenyl -2- trinitrophenyl-hydrazines (1, 1-diphenyl-2-picrylhydraryl, DPPH) free radical scavenging activity be 97.11%, the content in 68 kinds of common Chinese medicine materials Belong to highest, oxidation resistance is most strong, therefore is considered as a kind of main source of excellent natural.Amino acid in olive Content is higher, A wide selection of colours and designs, and wherein serine, threonine can be converted into collagen, can delay skin aging；Methionine has There is the effect of lipid-loweringing, removing toxic substances；Glutamic acid participates in the metabolism of brain albumen and carbohydrate, is to improve and maintain brain function indispensable Few amino acid is the drug of fabulous treatment eye illness.And the content of essential oil is up to 3% in yellow olive（With dry fruit meat gauge）, Essential oil generally has good anti-oxidant and fungistatic effect.Therefore, using olive as raw material develop lozenge have feasibility and preferably Market prospects.
Mainly there are slow tight Shu Ning olive buccal tablets, slow tight Shu Ning compounds green olive mouth-keeping tablet for reliving sore-throat, the green minister boards of OEM currently on the market Green good throat-fitting buccal tablet of olive etc., these olive buccal tablets have their own characteristics each.The present invention mainly from how to improve olive drug effect, enhancing olive wind Taste is started in terms of improving lozenge mouthfeel three, a kind of novel yellow olive mouth-keeping tablet for reliving sore-throat of exploitation.
The main component of yellow olive mouth-keeping tablet for reliving sore-throat is olive medicinal extract, and main flavor ingredient is olive essential oil.
Dextrin can prevent lozenge " sand return ", " molten ", enhance the bullet of lozenge as the food ingredient of yellow olive buccal tablet Property and toughness, change flavor, improve mouthfeel, prevent to deliquesce, eliminating and stick to one's teeth phenomenon, reduce odontopathy, Shelf-life.Xylitol, Be also one of important dispensing of lozenge, be unique polyol, can pre- anti-caries, the secretion of saliva can be promoted, supplement saliva Phosphorus in liquid and calcium, to promote the natural reparation of tooth；Liver glycogen synthesis is may additionally facilitate, is controlling for hepatitis and diabetic Treat articles for use.Radix Glycyrrhizae belongs to clinical commonly used drug, has stronger cough-relieving, antiinflammation.
This product can the resting period it is long, with anti-inflammatory, cough-relieving, relieving sore-throat main pharmacodynamics, also have that flavor is typical, mouthfeel is thin Greasy, anti-caries, anti-oxidant, anti-aging and other effects, and raw material sources are extensive, cheap, have good market prospects.
Invention content
That the object of the present invention is to provide a kind of products is easily molded, be not easily broken and surface smooth and beautiful appearance, flavor it is typical it is good, The preparation method of delicate mouthfeel and convenient yellow olive mouth-keeping tablet for reliving sore-throat.
Inventor has found：（1）Olive medicinal extract dosage is 40%, is conducive to the drug effect and mouthfeel that improve olive buccal tablet, and sense organ is commented Valence weight score is higher by 4.03 points and 3.39 points respectively than olive medicinal extract dosage for 30% and 50% respectively；（2）Xylitol dosage is When 12%, sugariness is relatively mild and mouthfeel is pure and fresh, and sensory evaluation weight score is distinguished when being respectively 10% and 14% than xylitol dosage It is higher by 3.52 points and 5.92 points.When xylitol dosage is 14%, the easy moisture absorption leads to the utilization rate of lozenge powder, and side effect is more Obviously；（3）Licorice powder dosage is 35%, is conducive to improve mouthfeel, sensory evaluation weight score is respectively 30% than licorice powder dosage It is higher by 3.00 points and 3.50 points respectively with 40%；（4）When dextrin dosage is 10%, sensory evaluation weight score is respectively 5% than dosage It is higher by 5.80 points and 1.50 points respectively with 10%.
The technical solution adopted by the present invention to solve the technical problems is：
A kind of preparation method of Huang olive mouth-keeping tablet for reliving sore-throat, the preparation method include the following steps：
（1）Make emblica powder：It using Maoming Huang olive as raw material, is freezed 12 hours at -5 DEG C, carries out Freezing smashing stoning processing； The meat air dry oven of broken olive is dried at 60 DEG C, olive meat is finally polished into powder, it is spare to cross 40 mesh sieve；
（2）Make olive medicinal extract：It by emblica powder obtained, is extracted with ultrasonic extracting machine, obtains extract liquor；By extract liquor It is filtered by vacuum to obtain smoke filtrate, smoke filtrate Rotary Evaporators are distilled to recover ethyl alcohol at 60 DEG C and are concentrated to give olive Medicinal extract；
（3）Make olive essential oil：By emblica powder obtained, using supercritical CO2Extraction, obtains yellow olive essential oil；
（4）Olive mouth-keeping tablet for reliving sore-throat makes：By mass percentage, by olive medicinal extract 40%, xylitol 12%, licorice powder 35%, dextrin 10%, olive essential oil 1%, citric acid 1%, magnesium stearate 0.5% and Peppermint essential oil 0.5% are through mixing, making soft material, granulation, drying, pressure Piece, sterilizing and packaging to get.
When preparing olive medicinal extract, ultrasonic extraction condition is：The ethanol solution that volume ratio is 60%, solid-liquid ratio 1:18, 60 DEG C, extraction time 40min of extraction temperature, extraction power are 210W.
When preparing olive essential oil, supercritical CO2Extraction conditions is：1L extraction kettles, CO2Flow 15-20Kg/h, each olive Olive powder dosage is 100g, and the extracting pressure of 15-25MPa extracts 4h at 45-55 DEG C.
In step（4）In, lozenge forming operation does not add moisture after dispensing mixing, utilizes olive essential oil and Peppermint essential oil Wetting action, lozenge powder is first made, then carry out sheeting operation, effectively overcome plus the direct granulation procedure of water wet feed make product Difficult forming, it is frangible, mouth containing easyization the problems such as.
Compared with prior art, the present invention has the following advantages：
1, the present invention selects olive medicinal extract as principal ingredients, instead of traditional pulp powder, has both effectively overcome pulp powder mouthfeel Coarse problem, and the bioactive ingredients such as flavones in olive, polyphenol, terpene and amino acid is made to be concentrated, improve drug effect valence Value.
It uses olive medicinal extract to replace traditional pulp powder for lozenge dispensing, both effectively overcomes asking for pulp powder coarse mouthfeel Topic, and the bioactive ingredients such as flavones in olive, polyphenol, terpene and amino acid is made to be concentrated, improve drug effect value.Using super Sound secondary organic solvent extracts, and effectively improves olive bioactive ingredients recovery rate.
2, the present invention not only makes lozenge have strong olive using the technique that olive essential oil is added back to lozenge is first prepared Flavor, replaces essence, the disadvantage for overcoming traditional operation flavor boring, can also play that olive essential oil is anti-oxidant and fungistatic effect.
3, present invention process is simple, at low cost, energy consumption is low, and production process is easily controllable；When carrying out forming operation, using elder generation The technique of olive buccal tablet powder processed tabletting again, effectively overcome plus the direct granulation procedure of water wet feed make formed product it is difficult, it is frangible, The problems such as sucking easyization.
4, prepare olive buccal tablet particle it is close, smooth surface, overcome moisture regain easily swell, be tacky, easy fracture the shortcomings of； A small amount of dextrin is added, the holding time can be extended；A small amount of magnesium stearate is added, can make that product is easily molded, is not easily broken.
Description of the drawings
Fig. 1 is the curve graph that olive medicinal extract additive amount of the present invention influences lozenge sensory evaluation.
Fig. 2 is the curve graph that xylitol additive amount of the present invention influences lozenge sensory evaluation.
Fig. 3 is the curve graph that licorice powder additive amount of the present invention influences lozenge sensory evaluation.
Fig. 4 is the curve graph that dextrin additive amount of the present invention influences lozenge sensory evaluation.
Specific implementation mode
Embodiment：
Make emblica powder：It using Maoming Huang olive as raw material, is freezed 12 hours at -5 DEG C, carries out Freezing smashing stoning processing；It will The broken meat air dry oven of olive is dried at 60 DEG C, and olive meat is finally polished into powder, and it is spare to cross 40 mesh sieve；
Make olive medicinal extract：It by emblica powder obtained, is extracted with ultrasonic extracting machine, ultrasonic extraction condition is：Volume Than the ethanol solution for 60%, solid-liquid ratio 1:18,60 DEG C, extraction time 40min of extraction temperature, extraction power is 210W, is obtained Extract liquor；Extract liquor is filtered by vacuum to obtain smoke filtrate, smoke filtrate is distilled to recover second with Rotary Evaporators at 60 DEG C Alcohol is simultaneously concentrated to give olive medicinal extract；
Make olive essential oil：By emblica powder obtained, using supercritical CO2Extraction, supercritical CO2Extraction conditions is：1L is extracted Kettle, CO2Flow 15-20Kg/h, each emblica powder dosage are 100g, and the extracting pressure of 20MPa extracts 4h at 50 DEG C, obtains Yellow olive essential oil；
Olive mouth-keeping tablet for reliving sore-throat makes：By mass percentage, by olive medicinal extract 40%, xylitol 12%, licorice powder 35%, dextrin 10%, olive essential oil 1%, citric acid 1%, magnesium stearate 0.5% and Peppermint essential oil 0.5% are through mixing, making soft material, granulation, drying, pressure Piece, sterilizing and packaging to get.

Claims (3)

1. a kind of preparation method of Huang olive mouth-keeping tablet for reliving sore-throat, which is characterized in that the preparation method includes the following steps：
（1）Make emblica powder：It using Maoming Huang olive as raw material, is freezed 12 hours at -5 DEG C, carries out Freezing smashing stoning processing； The meat air dry oven of broken olive is dried at 60 DEG C, olive meat is finally polished into powder, it is spare to cross 40 mesh sieve；
（2）Make olive medicinal extract：It by emblica powder obtained, is extracted with ultrasonic extracting machine, obtains extract liquor；By extract liquor It is filtered by vacuum to obtain smoke filtrate, smoke filtrate Rotary Evaporators are distilled to recover ethyl alcohol at 60 DEG C and are concentrated to give olive Medicinal extract；
（3）Make olive essential oil：By emblica powder obtained, using supercritical CO2Extraction, obtains yellow olive essential oil；
（4）Olive mouth-keeping tablet for reliving sore-throat makes：By mass percentage, by olive medicinal extract 40%, xylitol 12%, licorice powder 35%, dextrin 10%, olive essential oil 1%, citric acid 1%, magnesium stearate 0.5% and Peppermint essential oil 0.5% are through mixing, making soft material, granulation, drying, pressure Piece, sterilizing and packaging to get.
2. a kind of preparation method of yellow olive mouth-keeping tablet for reliving sore-throat according to claim 1, which is characterized in that preparing olive leaching When cream, ultrasonic extraction condition is：The ethanol solution that volume ratio is 60%, solid-liquid ratio 1:18,60 DEG C of extraction temperature, when extraction Between 40min, extraction power be 210W.
3. a kind of preparation method of yellow olive mouth-keeping tablet for reliving sore-throat according to claim 1, which is characterized in that preparing olive essence When oily, supercritical CO2Extraction conditions is：1L extraction kettles, CO2Flow 15-20Kg/h, each emblica powder dosage are 100g, 15- The extracting pressure of 25MPa extracts 4h at 45-55 DEG C.
CN201810131746.4A 2018-02-09 2018-02-09 A kind of preparation method of Huang olive mouth-keeping tablet for reliving sore-throat Pending CN108379322A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810131746.4A CN108379322A (en) 2018-02-09 2018-02-09 A kind of preparation method of Huang olive mouth-keeping tablet for reliving sore-throat

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810131746.4A CN108379322A (en) 2018-02-09 2018-02-09 A kind of preparation method of Huang olive mouth-keeping tablet for reliving sore-throat

Publications (1)

Publication Number Publication Date
CN108379322A true CN108379322A (en) 2018-08-10

Family

ID=63075471

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810131746.4A Pending CN108379322A (en) 2018-02-09 2018-02-09 A kind of preparation method of Huang olive mouth-keeping tablet for reliving sore-throat

Country Status (1)

Country Link
CN (1) CN108379322A (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101062101A (en) * 2007-06-01 2007-10-31 郑金营 Material formula of olive fruit buccal tablet and the preparing method thereof
CN101103793A (en) * 2007-08-07 2008-01-16 云南龙发制药有限公司 Olive keeping-in-mouth tablet and its preparation method
CN101356964A (en) * 2008-08-22 2009-02-04 华南农业大学 Olive buccal tablet and preparation method thereof
CN103070360A (en) * 2013-01-24 2013-05-01 普定县朵贝金苑茶厂 Olive preparation
CN103977062A (en) * 2014-04-19 2014-08-13 烟台恒迪克能源科技有限公司 Terminalia chebula Retz. lung-moistening sore throat-relieving lozenge and preparation method thereof
CN104431857A (en) * 2014-12-26 2015-03-25 范德和 Olive lozenge and production process thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101062101A (en) * 2007-06-01 2007-10-31 郑金营 Material formula of olive fruit buccal tablet and the preparing method thereof
CN101103793A (en) * 2007-08-07 2008-01-16 云南龙发制药有限公司 Olive keeping-in-mouth tablet and its preparation method
CN101356964A (en) * 2008-08-22 2009-02-04 华南农业大学 Olive buccal tablet and preparation method thereof
CN103070360A (en) * 2013-01-24 2013-05-01 普定县朵贝金苑茶厂 Olive preparation
CN103977062A (en) * 2014-04-19 2014-08-13 烟台恒迪克能源科技有限公司 Terminalia chebula Retz. lung-moistening sore throat-relieving lozenge and preparation method thereof
CN104431857A (en) * 2014-12-26 2015-03-25 范德和 Olive lozenge and production process thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
张玲等: "超声波辅助提取橄榄浸膏工艺研究 ", 《广东石油化工学院学报》 *
王羽梅: "《中国芳香植物精油成分手册（全三册）》", 31 May 2015, 华中科技大学出版社 *

Similar Documents

Publication Publication Date Title
CN101619271B (en) Traditional Chinese medicine combination spice for cigarette as well as preparation method and application thereof
CN102228180A (en) Betelnut buccal tablet and preparation method thereof
CN104336230A (en) Mulberry leaf sweet tea and preparation method thereof
CN106360213A (en) Rhizoma polygonati plant beverage and preparation method thereof
CN101028025A (en) Erythritol sandwiched chocolate
CN111149910A (en) Double ginseng chewing gum and preparation method thereof
CN104783180A (en) Chewable tablet containing freeze-dried anoectochilus roxburghii powder and preparation method of chewable tablet
CN107998240A (en) A kind of formula for the fatigue-relieving clearing health care buccal tablets that refresh the mind and preparation method thereof
CN105343141A (en) Preparation method of chewable tablets of water chestnut shell extract
CN105520964A (en) Preparation method and application of royal jelly and bee pollen composition
CN101933567B (en) Golden pomelo sugar-free mint lozenge and preparation method thereof
CN108379322A (en) A kind of preparation method of Huang olive mouth-keeping tablet for reliving sore-throat
CN102125128A (en) Nine-ingredient blood sugar reducing tea
CN101744986A (en) Extraction method for ginseng, ophiopogon root and schisandra chinensis and preparation thereof
JP2003192602A (en) Agent for hangover
CN105746819A (en) Instant betel nut tea and preparation method thereof
CN104920771A (en) Hawk-tea chewing gum with health-care efficacy and production method thereof
CN103519045B (en) Gynura and tremella honey and production method thereof
CN106615528A (en) Yin-nourishing and lung-clearing functional candies and preparation method thereof
CN104474406A (en) Health traditional Chinese medicine wine for nourishing yin and moistening lung and preparation method of health traditional Chinese medicine wine
CN101757115A (en) American ginseng mulberry leaf buccal tablet
CN104523985A (en) Cordyceps health-preservation traditional Chinese medicine liquor and preparation method thereof
CN101156640B (en) Kkudzu incense sugar and its formulating method
CN104277955A (en) Traditional Chinese medicine wine for tonifying qi, nourishing blood and preserving health and preparation method thereof
CN104371892A (en) Fleece-flower root hair-blacking traditional Chinese medicine wine and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20180810