CN108375545A - A kind of slice handling system and pathological section scanner - Google Patents
A kind of slice handling system and pathological section scanner Download PDFInfo
- Publication number
- CN108375545A CN108375545A CN201810068656.5A CN201810068656A CN108375545A CN 108375545 A CN108375545 A CN 108375545A CN 201810068656 A CN201810068656 A CN 201810068656A CN 108375545 A CN108375545 A CN 108375545A
- Authority
- CN
- China
- Prior art keywords
- slice
- box
- objective table
- station
- unloading
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000001575 pathological effect Effects 0.000 title claims abstract description 26
- 230000007246 mechanism Effects 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 13
- 230000009191 jumping Effects 0.000 claims description 12
- 230000003287 optical effect Effects 0.000 claims description 10
- 230000007704 transition Effects 0.000 claims description 6
- 230000001360 synchronised effect Effects 0.000 claims 1
- 230000008569 process Effects 0.000 description 11
- 230000001105 regulatory effect Effects 0.000 description 8
- 238000010586 diagram Methods 0.000 description 5
- 230000008859 change Effects 0.000 description 3
- 230000000007 visual effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 230000003028 elevating effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000004064 recycling Methods 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/04—Batch operation; multisample devices
- G01N2201/0446—Multicell plate, sequential
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The present invention provides a kind of slice handling system and pathological section scanners, including assembling and disassembling manipulator, slice box position adjusting apparatus and multiple slice boxes；At least one slice box is sky in multiple slice boxes, and empty slice box is switched to the unloading station of objective table under slice box position adjusting apparatus driving；Slice box position adjusting apparatus allows hand over and lifts slice box, so that the unloading station and load station of each slice slot alignment objective table in each slice box, traverse all slices to be scanned；Scanned slice on objective table can be moved into the corresponding slice box of objective table unloading station by assembling and disassembling manipulator, almost simultaneously, the slice to be scanned in the corresponding slice box of objective table unloading station is moved into objective table by assembling and disassembling manipulator.Since the loading of slice and unloading are carried out at the same time substantially, and the scanned position that can be adjusted slice box of slices need not be waited, so the time used in slice handling halves, the whole efficiency of scanner is improved.
Description
Technical field
The present invention relates to a kind of pathological section scanners can efficiently be loaded and unloaded and be cut with slice handling system more particularly to one kind
The slice handling system and pathological section scanner of piece.
Background technology
Its slice automatic assembling and disassembling system of pathological section scanner in the prior art mostly uses in CN201210411328.3
Push rod cooperation CN201320478999.1 in more slice loading systems, slice box is replaced by the rotation of rotary-tray, is led to
The front entrance that slice to be measured is directed at and is pushed into objective table by lifting gear and push rod one by one is crossed, draws the slice after the end of scan
Return the former slice slot of former slice box.So the complete cargo handling process of slice includes three sections of not overlapping steps：T1- will be carried
Scanned slice is moved back to the former slice slot of former slice box on object platform；The position of T2- adjustment slice boxes makes new slice alignment
Objective table front entrance；New slice to be scanned is moved into objective table by T3-.
A piece of slice is complete " sweep time " in the prior art, and actually some time is consumed the three of handling
In a step, really 70-80% is accounted for the time that camera is scanned.And due to being sliced frivolous frangible feature, charge and discharge operations
All too urgent too fast slice cannot be caused damaged in order to avoid generating improper thrust, improper thrust is it is also possible that scanning platform is unbalance, therefore
Existing handling system is difficult to compress the time used in these three steps.On the other hand, in order to ensure pathological section scanning height
Resolution ratio and the full visual field, under existence conditions, it is also difficult to shorten the time that camera is really scanned..
Invention content
The purpose of the present invention is in view of the above problems, providing a kind of efficient slice handling system and efficient pathological section
Scanner.
The present invention efficient slice handling system include：It loads slice box, unloading slice box, assembling and disassembling manipulator and cuts
Film magazine position regulator；The assembling and disassembling manipulator is used to slice scanned on objective table moving into unloading for objective table side
Carry slice box；Almost simultaneously, the slice in the loading slice box of the objective table other side is moved into objective table by assembling and disassembling manipulator；
The slice box position adjusting apparatus is for switching and lifting unloading slice box and load slice box, so that each unloading is sliced box
Interior each slice slot is aligned the unloading station of objective table one by one, and each each slice loaded in slice box is aligned loading one by one
The load station of platform traverses all slices to be scanned.
The assembling and disassembling manipulator can be that charging manipulator and unloading machinery hand are integrated, unload scanned cut
New slice to be scanned is loaded while piece；Another kind is arranged to individual charging manipulator and unloading machinery hand, load and
Unloading operation is independent, and the gap between objective table and slice handling system requires smaller.
Preferably, the loading slice box is that purposes is different with unloading slice box, and structure is the same, loads slice
After all slices in box are scanned, the position of unloading slice box can be placed in and be sliced box as new unloading, and original
Unloading slice box can also remove scanned slice, change new slice to be scanned.Slice box can be improved in this way
Utilization rate, reduce the expense of die sinking.
The loading slice box, unloading slice box and slice box position adjusting apparatus, can be two sets and be similar to background skill
More slice loading systems with round turntable bottom in art, or the handling system of multiple slice boxes arranged side by side can be accommodated
System, naturally it is also possible to be other slice handling systems in the prior art.
Since the present invention needs that unloading slice box is in addition arranged outside loading slice box, so compared to existing slice dress
Unloading system needs the space of bigger, will increase the volume of pathological section scanner.It is especially prodigious in slice capacity, it needs
Two sets of more slice loading systems being similar in CN201320478999.1 are used, the volume of scanner can be significantly increased.Cause
This, second object of the present invention is to provide a kind of slice handling system efficient, capacity is big and compact-sized.
In order to achieve the above objectives, slice handling system of the invention includes multiple slice boxes, slice box position adjusting apparatus
And assembling and disassembling manipulator, in the multiple slice box, at least one slice box is sky, under slice box position adjusting apparatus driving
It is directed at the unloading station of the objective table of micro optical system；It includes slice box elevating mechanism to be sliced box position adjusting apparatus, so that
It is sliced the unloading station and load station of each slice slot alignment objective table of box；It further includes surrounding to be sliced box position adjusting apparatus
The cavity for placing multiple slice boxes of scanner micro optical system setting, the slice box position adjusting apparatus being capable of band
Slice box in dynamic cavity is rotated relative to the objective table of micro optical system to switch different slice boxes, traverses all wait for
Scan slice；Slice scanned on objective table is moved into the corresponding slice of objective table unloading station by the assembling and disassembling manipulator
Box, almost simultaneously, the slice to be scanned in the corresponding slice box of objective table load station is moved into loading by assembling and disassembling manipulator
Platform.
Preferably, the slice box position adjusting apparatus further includes slice box angle-adjusting mechanism, slice box angle adjustment
Mechanism can adjust objective table load station slice box corresponding with unloading station, make its face objective table that is open, so as to protect
Movement locus of the card slice in cargo handling process is straight line.
The slice box position adjusting apparatus can be arranged to Lifting carrying platform load station independently and unloading work
The corresponding slice box in position, the slice slot where making the slice of loading are just aligned with the load station of objective table, and what is unloaded cuts
The piece slice slot to be entered just is aligned with the unloading station of objective table.This setup can independent adjustment loading cut
The height of film magazine and unloading slice box, needs two sets of independent height regulating mechanisms, but the load of single height regulating mechanism compared with
It is small.Wait for that the corresponding slice box of objective table load station is taken sky, the slice on objective table is scanned when being unloaded, both
The loading operation of slice can be carried out at the same time（Only loaded at this time as sky without loading slice）, can not also carry out simultaneously
The loading operation of slice；After the completion of unloading operation, empty slice box is gone to objective table and unloads work by slice box position adjusting apparatus
The corresponding position in position is sliced box as new unloading, and is sliced box to the corresponding new loading of objective table load station at this time, holds
It goes and is sliced loading operation, at this time without slice on objective table, both may be performed simultaneously the unloading operation of slice（Do not have at this time only
There is unloading to be sliced, loads as sky）, the unloading operation that can not also be sliced simultaneously.
Another set-up mode is the Lifting carrying platform load station and unloading that the slice box position adjusting apparatus synchronizes
The corresponding slice box of station, it is specific that objective table unloads the corresponding slice box of station slice box difference one corresponding with load station
Highly, the slice of the unloading slice slot to be moved into is made just to be aligned with the slice slice groove height to be removed of loading.It is this to set
The mode of setting needs the height regulating mechanism of two sets of synchronizations, and the load of height regulating mechanism is larger, but is easy to keep entire slice
The balance and stabilization of handling system.Wait for that the corresponding slice box of objective table load station is taken sky, the slice on objective table is swept
It retouches and finishes when being unloaded, can both be carried out at the same time the loading operation of slice（Only loads without loading slice at this time and be
It is empty）, the loading operation that can not also be sliced simultaneously；After the completion of unloading operation, slice box position adjusting apparatus cuts empty
Film magazine goes to the corresponding position of objective table unloading station as new unloading and is sliced box, and is corresponded to objective table load station at this time
New loading be sliced box, execute slice loading operation, at this time without slice on objective table, both may be performed simultaneously unloading for slice
Carry operation（Only loaded at this time as sky without unloading slice）, the unloading operation that can not also be sliced simultaneously.
Preferably, slice handling system further include auxiliary slice by objective table load station, station is corresponding cuts for unloading
The transition mechanism in the gap between film magazine and objective table crosses large slice to prevent gap and falls off or block；The transition mechanism is being cut
Piece bounces back when scanning, the relative motion for not influencing objective table and being sliced between handling system.
Each of slice handling system of present invention slice box can accommodate M piece pathological sections, include N number of slice box altogether
（Wherein M and N is the positive integer not less than 2）, one of slice box is sky, and cut-in without ball film magazine is directed at the unloading station of objective table
It is sliced box as the unloading for recycling scanned slice.Then the maximum slice capacity of the slice handling system is M*（N-1）Piece.
It is unloaded when all slices in the slice box positioned at objective table load station are scanned and move into objective table by assembling and disassembling manipulator
When carrying in the unloading slice box of station, the slice box of load station alignment is sky, and slice box position adjusting apparatus cuts empty
The unloading station that film magazine turns to objective table is sliced box as new unloading；In order to ensure that alignment objective table loads after rotating every time
Slice in the slice box of station is not scanned, needs to preset slice box position adjusting apparatus at a particular angle
Rotation, to traverse all slices to be scanned.Preferably, N number of slice box is relative to slice box position adjusting apparatus
Rotation axis is uniformly distributed for axle center, and slice box position adjusting apparatus rotates the angle of n slice box every time, and n is relatively prime just with N
Integer.Rotation N-2 times is then needed altogether, you can traverses the N-1 slice box for accommodating slice to be scanned one by one.
In scanning process, if desired to a certain slice or certain slices jump a queue processing priority scan when, then execute with
Lower operation：
1）The selected slice of jumping a queue for needing priority scan；
2）Without emptying article carrying platform if no slice on objective table, step 3 is directly executed）；
Objective table is emptied in the case of having slice on objective table：The slice is moved if the slice on objective table at this time not yet scans
Return the former slice slot of former slice box；If the slice is scanning its is scanned and move into objective table unloading station it is corresponding
It is sliced box；The corresponding slice box of objective table unloading station is moved into if the slice is scanned；
3）Slice box where the slice of jumping a queue is turned to objective table load station and lifted and cut by slice box position adjusting apparatus
Film magazine, so that slice of jumping a queue is aligned the load station of objective table one by one, assembling and disassembling manipulator will jump a queue to be sliced moves into objective table one by one
Be scanned, it is scanned after the assembling and disassembling manipulator slice that will jump a queue be moved back in the former slice slot of former slice box；
4）Wait for it is all jump a queue slice it is scanned, pathological section scanner continues the original operation before jumping a queue；
5）When encounter again jump a queue slice when, the slice handling system of pathological section scanner continuously performs charge and discharge operations twice,
It is sent into the corresponding slice box of objective table unloading station without the slice that will just jump a queue is scanned again.
Preferably, several idler wheels are set on objective table, are moved with the slice in assisted loading and unloading, loading mechanization is reduced
The load of hand.Preferably, the autonomous rotation that idler wheel can be controlled, drives slice thereon to move, and improves move to a certain extent
The speed of dynamic slice, to improve the efficiency of loading and unloading.
Preferably, slice information is marked with bar code on slice, bar code is arranged along the length direction of slice.Exist in this way
It loads in slicing processes to be scanned, when slice is moved to the visual field of the included scanning camera of scanner, the scanning camera shooting
Bar code information carries out bar code identification；Further, bar code image is repeatedly shot in loading slicing processes, is compared to examine
Look into whether slicing motion deviates from precalculated position.The scanning camera carried with scanner shoots bar code during loading slice
Slice information is identified, one when not only saving the time, but also it is not necessary that barcode scanner is separately provided, and loading mobile using slice
Dimension bar code relative scanning camera motion is shot, and motion scan camera is not necessarily to.
The present invention also provides a kind of pathological section scanners including above-mentioned slice handling system.
" alignment " in the present invention is meant in the height direction（That is Z-direction）Intimate same level, in the horizontal direction
On can there are gaps between objective table, but to be in objective table load station or the corresponding position of unloading station.
Above-mentioned specific implementation mode and preferred embodiment can be combined with each other in the absence of conflict, to obtain various groups
The technical solution of conjunction.
Slice handling system of the present invention and pathological section scanner can essentially simultaneously cut scanned
Piece unloads from objective table side and loads new slice from the objective table other side；And when carrying out pathological section scanning, slice
Box position adjusting apparatus has the position of sufficient time adjustment objective table load station slice box corresponding with station is unloaded, without
Camera scanning must be waited for finish.Finally, the time used in three steps of a complete slice cargo handling process can halve, then
" sweep time " of slice can reduce 10%-15%, improve the whole efficiency of scanner.
The slice handling system and pathological section scanner of the present invention can not only reach the skill halved the slice lay day
Art effect, and it is sliced capacity bigger, it is compact-sized, it is suitble to the large batch of pathological section of automatic business processing.
Description of the drawings
Fig. 1 is the schematic diagram of the slice handling system in the application specific embodiment；
Fig. 2 is a kind of schematic diagram of assembling and disassembling manipulator in the application specific embodiment；
Fig. 3 is the schematic diagram of another assembling and disassembling manipulator in the application specific embodiment；
Fig. 4 is the stereogram of another slice handling system in the application specific embodiment（Assembling and disassembling manipulator is omitted）；
Fig. 5 is the vertical view of another slice handling system in the application specific embodiment（Assembling and disassembling manipulator is omitted）；
Fig. 6 is the schematic diagram that box rotation traversal is sliced in the application specific embodiment；
Fig. 7 is objective table idler wheel and bar code movement schematic diagram in the application specific embodiment.
In order to make attached drawing more simple and clear, sectioning involved in figure only shows the slice in charge and discharge operations, omits
Other slices.
10- objective tables, 100- slices, 41- load slice box, and 42- unloadings are sliced box, 50- assembling and disassembling manipulators, and 51- is loaded
Manipulator, 52- unloading machinery hands, 200- bar codes, 300- idler wheels.
Specific implementation mode
Illustrate technical scheme of the present invention in order to clearer, below in conjunction with attached drawing to the specific implementation mode of the present invention
It is described.
Fig. 1 illustrate only objective table and with objective table load station and unloading the opposite slice box of station, height of the invention
The slice handling system of effect includes：Load slice box 41, unloading slice box 42, assembling and disassembling manipulator 50 and slice box position adjustment
Device；The unloading that the assembling and disassembling manipulator 50 is used to move into slice 100 scanned on objective table 10 objective table side is cut
Film magazine 42, almost simultaneously, the slice in the loading slice box 41 of the objective table other side is moved into loading by assembling and disassembling manipulator 50
Platform；The slice box position adjusting apparatus allows hand over and lifts loading slice box and unloading slice box, so that each unloading is cut
The unloading station of different slice slot alignment objective tables in film magazine, each load are sliced slice alignment objective table different in box
Load station traverses all slices to be scanned.
The assembling and disassembling manipulator 50 can be that Fig. 1, charging manipulator shown in Fig. 2 and unloading machinery hand are integrated,
New slice to be scanned is loaded while unloading scanned slice；Another kind is to be arranged to individually load as shown in Figure 3
Manipulator and unloading machinery hand, load in this way and unloading operation is independent, to the gap between objective table and slice handling system
It is required that smaller.
The assembling and disassembling manipulator 50, charging manipulator 51 and unloading machinery hand 52, may be used pushing away in background technology
Bar, Tiebar structure can also be other forms in the prior art.The master of the assembling and disassembling manipulator 50 of integral type in Fig. 1, Fig. 2
Body is substantially parallel with stage surface, and the main part of charging manipulator 51 and unloading machinery hand 52 in Fig. 3 is substantially and loading
Platform plane is vertical, and above two set-up mode is not the pattern being completely fixed, and those skilled in the art are according to specific feelings
The main body integrated mechanical hand vertical with stage surface or main part can also be arranged substantially and loading in the difference of condition
The split type or integral type that the parallel separate mechanical hand of platform plane, even main part form an angle with stage surface
Manipulator.
Preferably, the loading slice box 41 is that purposes is different with unloading slice box 42, and structure is the same, is loaded
After all slices for being sliced in box are scanned, the position that can be put into unloading slice box is sliced box as new unloading, and former
The unloading slice box come can also remove scanned slice, change new slice to be scanned.It can improve and cut in this way
The utilization rate of film magazine reduces the expense of die sinking.
The loading slice box, unloading slice box and slice box position adjusting apparatus, can be two sets and be similar to background skill
More slice loading systems with round turntable bottom in art, naturally it is also possible to be other slice handling systems in the prior art
System.
Since the present invention needs that unloading slice box is in addition arranged outside loading slice box, so compared to existing slice dress
Unloading system needs the space of bigger, will increase the volume of pathological section scanner.It is especially prodigious in slice capacity, it needs
Two sets of more slice loading systems being similar in CN201320478999.1 are used, the volume of scanner can be significantly increased.Cause
This, second object of the present invention is to provide a kind of slice handling system efficient, capacity is big and compact-sized.
In order to achieve the above objectives, as shown in Figure 4 and Figure 5（Assembling and disassembling manipulator is omitted in two figures）, slice dress of the invention
Unloading system includes multiple slice boxes, is sliced box position adjusting apparatus and assembling and disassembling manipulator, in the multiple slice box, at least one
A slice box is sky, the unloading station of the objective table of alignment micro optical system under slice box position adjusting apparatus driving；It cuts
Film magazine position regulator includes slice box elevating mechanism, so that the unloading station of each slice slot alignment objective table of slice box
And load station；Slice box position adjusting apparatus further includes around the setting of scanner micro optical system for placing multiple cut
The cavity of film magazine, the slice box position adjusting apparatus can drive load of the slice box relative to micro optical system in cavity
Object platform is rotated to switch different slice boxes, traverses all slices to be scanned；The assembling and disassembling manipulator can will be on objective table
Scanned slice moves into the corresponding slice box of objective table unloading station, and almost simultaneously, assembling and disassembling manipulator is by objective table
Slice to be scanned in the corresponding slice box of load station moves into objective table.
Preferably, as shown in figure 5, the slice box position adjusting apparatus further includes slice box angle-adjusting mechanism, slice
Box angle-adjusting mechanism can adjust objective table load station slice box corresponding with unloading station, make its face loading that is open
Platform, to can guarantee that movement locus of the slice in cargo handling process is straight line.
The slice box position adjusting apparatus can be arranged to Lifting carrying platform load station independently and unloading work
The corresponding slice box in position, the slice slot where making the slice of loading are just aligned with the load station of objective table, and what is unloaded cuts
The piece slice slot to be entered just is aligned with the unloading station of objective table.This setup can independent adjustment loading cut
The height of film magazine and unloading slice box, needs two sets of independent height regulating mechanisms, but the load of single height regulating mechanism compared with
It is small.Wait for that the corresponding slice box of objective table load station is taken sky, the slice on objective table is scanned when being unloaded, both
The loading operation of slice can be carried out at the same time（Only loaded at this time as sky without loading slice）, can not also carry out simultaneously
The loading operation of slice；After the completion of unloading operation, empty slice box is gone to objective table and unloads work by slice box position adjusting apparatus
The corresponding position in position is sliced box as new unloading, and is sliced box to the corresponding new loading of objective table load station at this time, holds
It goes and is sliced loading operation, at this time without slice on objective table, both may be performed simultaneously the unloading operation of slice（Do not have at this time only
There is unloading to be sliced, loads as sky）, the unloading operation that can not also be sliced simultaneously.
Another set-up mode is the Lifting carrying platform load station and unloading that the slice box position adjusting apparatus synchronizes
The corresponding slice box of station, it is specific that objective table unloads the corresponding slice box of station slice box difference one corresponding with load station
Highly, the slice of the unloading slice slot to be moved into is made just to be aligned with the slice slice groove height to be removed of loading.It is this to set
The mode of setting needs the height regulating mechanism of two sets of synchronizations, and the load of height regulating mechanism is larger, but is easy to keep entire slice
The balance and stabilization of handling system.Wait for that the corresponding slice box of objective table load station is taken sky, the slice on objective table is swept
It retouches and finishes when being unloaded, can both be carried out at the same time the loading operation of slice（Only loads without loading slice at this time and be
It is empty）, the loading operation that can not also be sliced simultaneously；After the completion of unloading operation, slice box position adjusting apparatus cuts empty
Film magazine goes to the corresponding position of objective table unloading station as new unloading and is sliced box, and is corresponded to objective table load station at this time
New loading be sliced box, execute slice loading operation, at this time without slice on objective table, both may be performed simultaneously unloading for slice
Carry operation（Only loaded at this time as sky without unloading slice）, the unloading operation that can not also be sliced simultaneously.
Preferably, slice handling system further include auxiliary slice by objective table load station, station is corresponding cuts for unloading
The transition mechanism in the gap between film magazine and objective table crosses large slice to prevent gap and falls off or block；The transition mechanism is being cut
Piece bounces back when scanning, the relative motion for not influencing objective table and being sliced between handling system.
It should be noted that the loading slice box 41 in Fig. 4 and Fig. 5 and unloading slice box 42, distinguish only slice box
Objective table load station was corresponded at that time still unloads station, once slice box adjusting apparatus has adjusted the position of slice box, name
Claim nature can be with position change.
Each of slice handling system of present invention slice box can accommodate M piece pathological sections, include N number of slice box altogether
（Wherein M and N is the positive integer not less than 2）, one of slice box is sky, and cut-in without ball film magazine is directed at the unloading station of objective table
It is sliced box as the unloading for recycling scanned slice.Then the maximum slice capacity of the slice handling system is M*（N-1）Piece.
When all slices in the slice box positioned at objective table load station are scanned and be pushed by assembling and disassembling manipulator/pull in loading
When platform is unloaded in the unloading slice box of station, the slice box of load station alignment is sky, and slice box position adjusting apparatus will be empty
Slice box turn to the unloading station of objective table and be sliced box as new unloading；In order to ensure to be directed at objective table after rotating every time
Slice in the slice box of load station is not scanned, needs to preset slice box position adjusting apparatus with specific
Angular turn, to traverse all slices to be scanned.Preferably, N number of slice box is relative to slice box position adjustment dress
The rotation axis set is uniformly distributed for axle center, and slice box position adjusting apparatus rotates the angle of n slice box every time, and n is relatively prime with N
Positive integer.Rotation N-2 times is then needed altogether, you can traverses the N-1 slice box for accommodating slice to be scanned one by one.
It is further preferred that the N is odd number, n is (N-1)/2, at this time from slice box is loaded to objective table again from loading
During the entire process of platform is sliced box to unloading, the angle for being sliced rotation is smaller, and the objective table of micro optical system close can be cut
Piece handling system it is centrally disposed, the structure of scanner can be made more compact.
Fig. 6 shows the case where box rotation traversal is sliced when N is 9 and n is 4, is numbered clockwise in initial position slice box
1-9, by rotating the constant only multiple concentric circles in objective table rotation, Fig. 4 of each slice box number（Ring）By interior yearning
The arrangement of initial position slice box is indicated successively and the arrangement of box is sliced after rotating for the 1-7 times.Assuming that in initial position, number 1
Slice box alignment objective table load station be load slice box, number 5 cut-in without ball film magazine alignment objective table unloading station
It is sliced box for unloading, slice to be scanned is accommodated in the slice box of number 1,2,3,4,6,7,8,9.It is sliced in box in number 1
All slices it is scanned and unload and move into the slice box of number 5, the slice box of number 1 is sky, the 1st rotation 4
After being sliced the angle of box, the slice box of number 1 is just rotated into the unloading station of objective table as new unloading slice box, number
The load station that 6 slice box then turns to objective table is sliced box as new loading；When the slice box of number 6 is empty, the 2nd
The slice box of the angle of 4 slice boxes of secondary rotation, number 6 is just rotated into the unloading station of objective table as new unloading slice
The slice box of box, number 2 then turns to the load station of objective table as new loading slice box；Wait for that the slice box of number 2 is
When empty, the angles of 4 slice boxes of the 3rd rotation, the slice box of number 2 is just rotated into the unloading station of objective table as newly
The slice box of unloading slice box, number 7 then turns to the load station of objective table as new loading slice box；Wait for number 7
When slice box is empty, the 4th rotates the angles of 4 slice boxes, and the slice box of number 7 is just rotated into the unloading station of objective table
It is sliced box as new unloading, the slice box of number 3 then turns to the load station of objective table as new loading slice box；It waits for
When the slice box of number 3 is empty, the 5th rotates the angle of 4 slice boxes, and the slice box of number 3 is just rotated into objective table
It unloads station and is sliced box as new unloading, the slice box of number 8 then turns to the load station of objective table as new loading
It is sliced box；When the slice box of number 8 is empty, the angle of 4 slice boxes of the 6th rotation, the slice box of number 8 is just rotated into
The unloading station of objective table is sliced box as new unloading, and the slice box of number 4 then turns to the load station conduct of objective table
New loading is sliced box；When the slice box of number 4 is empty, the angle of 4 slice boxes of the 7th rotation, the slice box of number 4 is just
The unloading station for turning to objective table well is sliced box as new unloading, and the slice box of number 9 then turns to the loading of objective table
Station is sliced box as new loading；All slices that number 9 is sliced in box are scanned through, then are sliced handling system unduplicated time
All slices to be scanned in 8 slice boxes of number 1,6,2,7,3,8,4,9 are gone through.
Fig. 6 gives the rotation traversal method of the slice handling system of full load conditions, if slice handling system underload,
The sequence not necessarily traversed according to above-mentioned rotation, it is only necessary to which traversing all slices to be scanned can terminator.
In scanning process, if desired to a certain slice or certain slices jump a queue processing priority scan when, then execute with
Lower operation：
1）The selected slice of jumping a queue for needing priority scan；
2）Without emptying article carrying platform if no slice on objective table, step 3 is directly executed）；
Objective table is emptied in the case of having slice on objective table：The slice is moved if the slice on objective table at this time not yet scans
Return the former slice slot of former slice box；If the slice is scanning its is scanned and move into objective table unloading station it is corresponding
It is sliced box；The corresponding slice box of objective table unloading station is moved into if the slice is scanned；
3）Slice box where the slice of jumping a queue is turned to objective table load station and lifted and cut by slice box position adjusting apparatus
Film magazine, so that slice of jumping a queue is aligned the load station of objective table one by one, assembling and disassembling manipulator will jump a queue to be sliced moves into objective table one by one
Be scanned, it is scanned after the assembling and disassembling manipulator slice that will jump a queue be moved back in the former slice slot of former slice box；
4）Wait for it is all jump a queue slice it is scanned, pathological section scanner continues the original operation before jumping a queue；
5）When encounter again jump a queue slice when, the slice handling system of pathological section scanner continuously performs charge and discharge operations twice,
It is sent into the corresponding slice box of objective table unloading station without the slice that will just jump a queue is scanned again.
Preferably, as shown in fig. 7, multiple idler wheels 300 are arranged on objective table 10, with the slice in assisted loading and unloading
100 movements, reduce the load of loading and unloading manipulator 50.Further, the autonomous rotation that the idler wheel 300 can be controlled drives
Slice movement thereon, improves the speed of mobile slice, to improve the efficiency of loading and unloading to a certain extent.Arrow in Fig. 2 is used
It is sliced a kind of setting in the general direction of slicing motion in handling system in instruction the application, is not intended to limit this application, is sliced
It can also move in the opposite direction, movement locus is also likely to be non-directional.
Preferably, as shown in Fig. 2, marking slice information, 200 edge of the bar code with bar code 200 on slice 100
The length direction setting of slice 100.In this way in loading slicing processes to be scanned, slice is moved to the included line phase of scanner
When the visual field of machine, line camera shoots bar code information, carries out bar code identification；Further, it is repeatedly shot in loading slicing processes
Bar code image is compared to check whether slicing motion deviates from precalculated position.The camera carried with scanner is cut in loading
Bar code is shot during piece to identify slice information, not only saves the time, but also it is not necessary that barcode scanner, Er Qieli is separately provided
Bar code 200 is shot with respect to line camera uniform motion when loading mobile with slice, is not necessarily to portable cord camera.
It should be noted that mentioned in the application slice scanning when, slice handling when, answer broad sense be interpreted as slice fill
Unload operation or scan operation start before, even just start when starting after a period of time in, not strict requirements
While being sliced charge and discharge operations or scan operation carries out.
Each preferred embodiment of above-mentioned each specific embodiment and each specific embodiment can in the absence of conflict mutual group
It closes, to obtain the technical solution of various combinations.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the general of this field
For logical technical staff, the invention may be variously modified and varied.All within the spirits and principles of the present invention, appoint made by
What modification, equivalent replacement etc., should all be included in the protection scope of the present invention.
Claims (9)
1. a kind of slice handling system, including assembling and disassembling manipulator, slice box position adjusting apparatus and multiple slice boxes, feature exist
In at least one slice box is sky in the multiple slice box, and empty slice box is under slice box position adjusting apparatus driving
It is switched to the unloading station of objective table；The slice box position adjusting apparatus allows hand over and lifts slice box, so that each cut
The unloading station and load station of each slice slot alignment objective table of film magazine, traverse all slices to be scanned；The handling
Slice scanned on objective table can be moved into the corresponding slice box of objective table unloading station by manipulator, almost simultaneously
, the slice to be scanned in the corresponding slice box of objective table load station is moved into objective table by assembling and disassembling manipulator.
2. slice handling system according to claim 1, which is characterized in that the slice box position adjusting apparatus further includes
Around the cavity for placing multiple slice boxes of micro optical system setting；The slice box position adjusting apparatus can drive
Slice box in cavity is rotated relative to the objective table of micro optical system to switch different slice boxes.
3. slice handling system according to claim 2, which is characterized in that the slice box position adjusting apparatus further includes
It is sliced box angle-adjusting mechanism, it is corresponding with unloading station that the slice box angle-adjusting mechanism can adjust objective table load station
Slice box, make its be open face objective table.
4. slice handling system according to claim 2, which is characterized in that the slice box position adjusting apparatus difference is only
Vertical Lifting carrying platform load station slice box corresponding with unloading station, the slice slot for making the slice of loading be removed and unloading
The slice slice slot to be moved into respectively with the load station of objective table and unloading station be aligned.
5. slice handling system according to claim 2, which is characterized in that the slice box position adjusting apparatus synchronized
Lifting carrying platform load station slice box corresponding with unloading station, objective table unload the corresponding slice box of station and load station
Corresponding slice box differs a certain height, makes what the slice of the slice of the unloading slice slot to be moved into and loading to be removed to cut
Film trap is aligned with the load station of objective table and unloading station respectively.
6. slice according to claim 2 loads, which is characterized in that including N number of slice box, N number of slice box is opposite
It is uniformly distributed centered on the rotation axis of slice box position adjusting apparatus, objective table load station and unloading station are two corresponding
It is sliced box and differs the angle of n slice box, and it is sky to unload the corresponding slice box of station originally, whenever objective table load station institute
After slice in corresponding slice box is scanned and all immigration objective table unloads the corresponding slice box of station, it is sliced box position
Adjusting apparatus drives all slice boxes to rotate the angle of n slice box, and empty slice box is gone to objective table unloading station and is corresponded to
Position, continue handling with scanning objective table load station it is corresponding slice box in slice to be scanned, until traversal needed
The slice of scanning, wherein n and N are that relatively prime positive integer and n are less than N.
7. a kind of pathological section scanner, which is characterized in that including micro optical system and claim 1-6 any one of them
It is sliced handling system.
8. pathological section scanner according to claim 7, which is characterized in that further include that auxiliary slice is filled by objective table
Carry the transition mechanism in the gap between the corresponding slice box of station, unloading station and objective table；The transition mechanism is swept in slice
It bounces back when retouching, the relative motion for not influencing objective table and being sliced between handling system.
The method of slice 9. the pathological section scanner priority scan in a kind of claim 7 is jumped a queue, it is characterised in that including with
Lower step：
1）The selected slice of jumping a queue for needing priority scan；
2）Without emptying article carrying platform if no slice on objective table, step 3 is directly executed）；
Objective table is emptied in the case of having slice on objective table：The slice is moved if the slice on objective table at this time not yet scans
Return the former slice slot of former slice box；If the slice is scanning its is scanned and move into objective table unloading station it is corresponding
It is sliced box；The corresponding slice box of objective table unloading station is moved into if the slice is scanned；
3）Slice box where the slice of jumping a queue is turned to objective table load station and lifted and cut by slice box position adjusting apparatus
Film magazine, so that slice of jumping a queue is directed at the load station of objective table one by one, assembling and disassembling manipulator will jump a queue to be sliced moves into objective table one by one
Be scanned, it is scanned after the assembling and disassembling manipulator slice that will jump a queue be moved back in the former slice slot of former slice box；
4）Wait for it is all jump a queue slice it is scanned, pathological section scanner continues the original operation before jumping a queue；
5）When encounter again jump a queue slice when, the slice handling system of pathological section scanner continuously performs charge and discharge operations twice,
It is sent into the corresponding slice box of objective table unloading station without the slice that will just jump a queue is scanned again.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810068656.5A CN108375545A (en) | 2018-01-24 | 2018-01-24 | A kind of slice handling system and pathological section scanner |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810068656.5A CN108375545A (en) | 2018-01-24 | 2018-01-24 | A kind of slice handling system and pathological section scanner |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108375545A true CN108375545A (en) | 2018-08-07 |
Family
ID=63016738
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810068656.5A Pending CN108375545A (en) | 2018-01-24 | 2018-01-24 | A kind of slice handling system and pathological section scanner |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108375545A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109870587A (en) * | 2019-02-25 | 2019-06-11 | 宁波江丰生物信息技术有限公司 | A kind of device and method of automatic load scan slice |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN202281746U (en) * | 2010-03-06 | 2012-06-20 | 伊鲁米那股份有限公司 | Measuring equipment for detecting optical signal from sample as well as optical module and optical system for measuring equipment |
| CN203798718U (en) * | 2013-08-06 | 2014-08-27 | 宁波江丰生物信息技术有限公司 | Multiple-slice loading system |
| CN106125281A (en) * | 2016-08-22 | 2016-11-16 | 麦克奥迪实业集团有限公司 | A kind of active tilt formula automatic entrance-exit sheet scanning microscope and enter rejecting method |
| CN207816993U (en) * | 2018-01-24 | 2018-09-04 | 南京图思灵智能科技有限责任公司 | A kind of slice handling system and pathological section scanner |
-
2018
- 2018-01-24 CN CN201810068656.5A patent/CN108375545A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN202281746U (en) * | 2010-03-06 | 2012-06-20 | 伊鲁米那股份有限公司 | Measuring equipment for detecting optical signal from sample as well as optical module and optical system for measuring equipment |
| CN203798718U (en) * | 2013-08-06 | 2014-08-27 | 宁波江丰生物信息技术有限公司 | Multiple-slice loading system |
| CN106125281A (en) * | 2016-08-22 | 2016-11-16 | 麦克奥迪实业集团有限公司 | A kind of active tilt formula automatic entrance-exit sheet scanning microscope and enter rejecting method |
| CN207816993U (en) * | 2018-01-24 | 2018-09-04 | 南京图思灵智能科技有限责任公司 | A kind of slice handling system and pathological section scanner |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109870587A (en) * | 2019-02-25 | 2019-06-11 | 宁波江丰生物信息技术有限公司 | A kind of device and method of automatic load scan slice |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109748027A (en) | A kind of body feed tank automatic selecting machine device people and its control method | |
| CN108773647B (en) | Circulation feeder | |
| CN208811304U (en) | Multistation laser marking device | |
| CN108857078A (en) | Multistation laser marking device and its application method | |
| CN108181325A (en) | Glass defect automatic detection device | |
| CN109761003A (en) | Device for transporting objects, material cleaning equipment and method | |
| CN206343401U (en) | A kind of discharge sorting mechanism | |
| CN207816993U (en) | A kind of slice handling system and pathological section scanner | |
| CN107416534A (en) | Automatic feeding system | |
| CN108375545A (en) | A kind of slice handling system and pathological section scanner | |
| CN108037127A (en) | A kind of pathological section scanner | |
| CN208091928U (en) | A kind of pathological section scanner | |
| JP2564235B2 (en) | Automatic polishing apparatus and polishing method for single-sided processing | |
| CN108169231A (en) | A kind of pathological section scanner of large capacity | |
| CN214323387U (en) | Logistics robot with multilayer storage structure | |
| CN112405338B (en) | Automatic feeding and discharging device and method for aluminum substrate grinding machine | |
| CN207718408U (en) | A kind of efficiently slice handling system and pathological section scanner | |
| CN109733777B (en) | Three-dimensional bunching device | |
| EP0753476A1 (en) | Automatic unloading of a cutting machine | |
| CN108090537A (en) | A kind of efficient section handling system and pathological section scanner | |
| CN214240896U (en) | Aluminum formwork transfer trolley | |
| KR20130031783A (en) | Integrated conveyor device and method of using the same | |
| CN208485241U (en) | A kind of feeding cycle device | |
| CN210084282U (en) | Box moving system and medicine production equipment | |
| EP0395288B1 (en) | Method and apparatus for unloading boxes or the like |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180807 |
|
| WD01 | Invention patent application deemed withdrawn after publication |