CN108348523A - 包含pi3k抑制剂和hdac抑制剂的组合物 - Google Patents

包含pi3k抑制剂和hdac抑制剂的组合物 Download PDF

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Publication number
CN108348523A
CN108348523A CN201680058695.6A CN201680058695A CN108348523A CN 108348523 A CN108348523 A CN 108348523A CN 201680058695 A CN201680058695 A CN 201680058695A CN 108348523 A CN108348523 A CN 108348523A
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alkyl
composition
bases
formula
kit
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斯蒂芬·约瑟夫·沙特勒沃斯
安德鲁·大卫·惠尔
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Karus Therapeutics Ltd
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Karus Therapeutics Ltd
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61P37/02—Immunomodulators
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim

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  • Rheumatology (AREA)
  • Hematology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Physiology (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201680058695.6A 2015-08-19 2016-08-19 包含pi3k抑制剂和hdac抑制剂的组合物 Pending CN108348523A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1514756.4A GB201514756D0 (en) 2015-08-19 2015-08-19 Compound and method of use
GB1514756.4 2015-08-19
PCT/GB2016/052571 WO2017029514A1 (en) 2015-08-19 2016-08-19 Compositions comprising a pi3k inhibitor and an hdac inhibitor

Publications (1)

Publication Number Publication Date
CN108348523A true CN108348523A (zh) 2018-07-31

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CN201680058695.6A Pending CN108348523A (zh) 2015-08-19 2016-08-19 包含pi3k抑制剂和hdac抑制剂的组合物

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Country Link
US (1) US20180243317A1 (enExample)
EP (2) EP3456355A1 (enExample)
JP (1) JP2018528192A (enExample)
KR (1) KR20180069788A (enExample)
CN (1) CN108348523A (enExample)
AU (1) AU2016307882A1 (enExample)
BR (1) BR112018003026A2 (enExample)
CA (1) CA2995991A1 (enExample)
GB (1) GB201514756D0 (enExample)
HK (1) HK1251466A1 (enExample)
IL (1) IL257521A (enExample)
MX (1) MX2018001990A (enExample)
SG (1) SG10201913619XA (enExample)
WO (1) WO2017029514A1 (enExample)

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CN111686097A (zh) * 2020-07-31 2020-09-22 上海交通大学医学院附属第九人民医院 Lmk235在抑制瘢痕形成的药物中的应用
CN114890989A (zh) * 2022-05-25 2022-08-12 佛山市晨康生物科技有限公司 一种含氮衍生物为Linker的HDAC8降解剂其制备方法和应用
CN116987073A (zh) * 2023-08-03 2023-11-03 嘉兴学院 一种PI3Kα/HDAC6亚型选择性双重抑制剂及其应用
WO2024184266A1 (en) * 2023-03-03 2024-09-12 Ionctura Sa Combination of roginolisib and hdac inhibitor in the treatment of haematological malignancy
CN118750492A (zh) * 2024-07-15 2024-10-11 中日友好医院(中日友好临床医学研究所) 一种hdac6高选择抑制剂cay10603的应用

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JP5746172B2 (ja) 2009-08-20 2015-07-08 カルス セラピューティクス リミテッド ホスホイノシチド３−キナーゼ阻害剤としての三環式複素環化合物
GB201204125D0 (en) 2012-03-08 2012-04-25 Karus Therapeutics Ltd Compounds
EP2994465B1 (en) 2013-05-10 2018-08-15 Karus Therapeutics Limited Novel histone deacetylase inhibitors
GB201402431D0 (en) 2014-02-12 2014-03-26 Karus Therapeutics Ltd Compounds
GB201514754D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds
GB201514758D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Formulation
GB201514760D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds and method of use
GB201514751D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
WO2018165520A1 (en) 2017-03-10 2018-09-13 Vps-3, Inc. Metalloenzyme inhibitor compounds
US12128018B2 (en) 2018-01-12 2024-10-29 KDAc Therapeutics, Inc. Combination of a selective histone deacetylase 3 (HDAC3) inhibitor and an immunotherapy agent for the treatment of cancer
EP3826998A4 (en) * 2018-07-23 2022-06-01 The Regents of the University of California COMPOSITIONS AND METHODS OF TREATING AN EPIGENETIC DISEASE
KR102162744B1 (ko) * 2018-09-18 2020-10-07 인제대학교산학협력단 프라시노스타트를 포함하는 염증성 장질환 치료용 약학 조성물
GB201909468D0 (en) 2019-07-01 2019-08-14 Karus Therapeutics Ltd Compounds for treating cancer
CN114727974A (zh) 2019-07-30 2022-07-08 艾科尼佐治疗股份有限公司 Hdac6抑制剂及其用途
GB201913121D0 (en) * 2019-09-11 2019-10-23 Seald As Compositions and methods for treatment of cholangiocarcinoma
WO2021113401A2 (en) * 2019-12-02 2021-06-10 The Regents Of The University Of Colorado, A Body Corporate Histone deacytlase 6 modulation of titin protein mediated cardiac tissue stiffness and method for same
TW202134245A (zh) 2019-12-05 2021-09-16 美商邊際分析公司 稠合三環雜環化合物及其用途
EP4076448A4 (en) 2019-12-20 2024-03-27 Tenaya Therapeutics, Inc. Fluoroalkyl-oxadiazoles and uses thereof
WO2022169882A1 (en) 2021-02-03 2022-08-11 Verge Analytics, Inc. Methods and treatment of viral infection caused by sars-cov-2
EP4333841A1 (en) 2021-05-04 2024-03-13 Tenaya Therapeutics, Inc. 2-fluoroalkyl-1,3,4-oxadiazol-5-yl-thiazol, hdac6 inhibitors for use in the treatment of metabolic disease and hfpef

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US20180243317A1 (en) 2018-08-30
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