CN108344717A - Accurate coagulation analysis instrument and its control method - Google Patents
Accurate coagulation analysis instrument and its control method Download PDFInfo
- Publication number
- CN108344717A CN108344717A CN201810129559.2A CN201810129559A CN108344717A CN 108344717 A CN108344717 A CN 108344717A CN 201810129559 A CN201810129559 A CN 201810129559A CN 108344717 A CN108344717 A CN 108344717A
- Authority
- CN
- China
- Prior art keywords
- sample
- signal
- instrument
- sample chamber
- optical detector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/59—Transmissivity
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Present invention is disclosed a kind of accurate coagulation analysis instruments, instrument is equipped with the sample chamber for storing blood sample, one end of the sample chamber is equipped with light source, the other end of the sample chamber is equipped with optical detector, instrument is equipped with taper type sample rack, the angles such as the sample rack periphery are equipped at least two sample chambers, the light that the light source projects projects light beam identical with sample chamber quantity through optical splitter, it is equipped between the sample rack and optical detector by the barn door of motor driving rotation, the shaft of the barn door is coaxial with sample rack, the edge of the barn door, which is equipped with, only holds the loophole that light beam injects optical detector.The advantage of the invention is that the turbidimetry blood coagulation analyzer technology based on existing maturation, by changing the fixed structure of sample, multiple samples can be analyzed simultaneously, and can improve accuracy of measurement, it is smaller compared with existing product cost increase simultaneously, improve the working efficiency of analyzer.
Description
Technical field
The present invention relates to medical instrument more particularly to blood coagulation analyzers.
Background technology
Various composition content in blood of human body, quantitative biochemical analysis knot are measured on coaglation analyzer category medicinal
Fruit provides reliable digit foundation for the various diseases of clinical diagnosis patient, is clinical indispensable conventional detection apparatus.
Such as have the instrument that blood coagulation data are obtained using turbidimetry at present, according to sample to be tested in process of setting
The variation of absorbance determines Coagulated hemothorax, after the directional light generated using light source passes straight through the sample of reaction tube, passes through light
Detector receives optical signal, and light source and optical detector are on same straight line, after blood clotting activator is added in sample, beginning
Absorbance is very weak, and with the formation of fibrin blood coagulation in reaction tube, sample absorbance also gradually increases therewith, when grumeleuse is complete
After being shaped as, absorbance region constant, computer depicts absorbance change song by obtaining the change in optical signal of optical detector
Line, and the wherein certain point corresponding time is set as setting time.
But the instrument for obtaining blood coagulation data using turbidimetry at present can only once test a sample, working efficiency
It is low, and because only testing a sample every time, if light source etc. has exception, can not also know to break down quickly, to shadow
Ring the accuracy measured.
Invention content
The technical problem to be solved by the present invention is to realize a kind of instrument obtaining blood coagulation data using turbidimetry, energy
Enough while multiple samples are measured, and can guarantee the blood coagulation analyzer of measurement accuracy.
To achieve the goals above, the technical solution adopted by the present invention is：Accurate coagulation analysis instrument, instrument are equipped with and are used for
The sample chamber of blood sample is stored, one end of the sample chamber is equipped with light source, and the other end of the sample chamber is equipped with optical detector,
The light that the light source is sent out injects optical detector after passing through the blood sample in sample chamber, and the photodetector output signal is extremely
Computer, instrument are equipped with taper type sample rack, and the angles such as described sample rack periphery are equipped at least two sample chambers, the sample rack
Smaller one end towards optical detector, larger one end towards optical splitter, the light that the light source projects through optical splitter project with
The identical light beam of sample chamber quantity, each light beam are each passed through a sample chamber, and the optical detector is located at all light beams
Focal position, between the sample rack and optical detector be equipped with by motor driving rotation barn door, the barn door turn
Axis is coaxial with sample rack, and the edge of the barn door, which is equipped with, only holds the loophole that light beam injects optical detector.
The barn door edge is equipped with signal teeth, and instrument is equipped with the signal reader for obtaining signal teeth signal, the signal
Reader exports barn door rotating speed and loophole position signal to computer, and the motor is stepper motor, and the computer is defeated
Go out rotary speed regulating signal to the driving circuit of motor.
When using instrument every time, one of them described sample chamber is vacant.
The sample rack is equipped with handle, and the instrument is equipped with the cavity for placing sample rack, and the cavity entrance is equipped with
Groove for being embedded in handle.
Each sample chamber is equipped with number, and the position of the signal teeth and the position of loophole are located at the same of barn door
Side.
When sample rack is put into instrument, one of them sample chamber number opposite with signal reader position is 1, institute
Sample chamber is stated with barn door direction of rotation serial number.
Control method based on the accurate coagulation analysis instrument：
Sample rack is put into instrument after putting samples into sample chamber, starts instrument later；
Instrument is rotated according to setting speed driving motor；
If sample chamber is n, after motor often rotates a circle, optical detector acquisition signal is divided into n parts, and compile according to this
Number be 1,2,3 ... n；
Identical signal will be numbered every time to be stored together, and a certain volume is constituted according to the time sequencing continuous arrangement of acquisition
Number signal set；
Required blood parameters are obtained by computer according to the signal set of each number.
When signal reader detects signal teeth, the beginning that rotates a circle as motor.
When motor works, signal correction motor speed that instrument obtains in real time according to signal reader.
At least one sample chamber is vacant, and light beam is preset in computer and is irradiated to optical detector after vacant sample chamber
Critical field value, instrument complete test after, when there are a signal set constant and numerical value in critical field value, then it represents that work
Make normally, otherwise to alarm.
The advantage of the invention is that the turbidimetry blood coagulation analyzer technology based on existing maturation, by changing sample
Fixed structure can analyze multiple samples, and can improve accuracy of measurement simultaneously, while smaller compared with existing product cost increase,
Improve the working efficiency of analyzer.
Description of the drawings
The content of every width attached drawing expression in description of the invention and the label in figure are briefly described below：
Fig. 1 is accurate coagulation analysis instrument structural schematic diagram；
Fig. 2 is sample rack structural schematic diagram；
Fig. 3 is anti-dazzle plate structure schematic diagram；
Label in above-mentioned figure is：1, light source；2, optical splitter；3, sample rack；4, sample chamber；5, handle；6, barn door；
7, loophole；8, signal teeth；9, signal reader；10, optical detector.
Specific implementation mode
The operation principle of instrument is believed light by optical detector 10 using conventional turbidimetry blood coagulation analyzer technology
Number be converted into electric signal, then these electric signals be delivered to computer, by computer analysis obtain needed for parameter, such as blood clotting
Time, computer include at least processing unit, display device, storage device.
Instrument sets the sample rack 3 there are one taper type, and the sample chamber 4 for storing blood is arranged on the periphery of sample rack 3,
Sample chamber 4 waits angles setting each other, and each angle of inclination is identical each along the setting of 3 inclined-plane of sample rack, 4 both ends of sample chamber
Transparent light transmission can be used for the container for placing storage blood sample as the container for placing blood.Sample chamber 4 to
Two are arranged less, is preferably provided with 6-10, then can measure multiple samples simultaneously.
The light that the smaller one end of sample rack 3 is projected towards optical detector 10, larger one end towards optical splitter 2, light source 1
Light beam identical with 4 quantity of sample chamber is projected through optical splitter 2, the brightness of each light beam is identical, and the use of optical splitter 2 is conventional to incite somebody to action
Light beam decile is divided into the device of multi beam, and the light that light source 1 is sent out divides through optical splitter 2 is each passed through sample chamber 4 for multi beam
Optical detector 10 is injected after interior blood sample, optical detector 10 is located at the focal position of all light beams.
Can only receive a light beam to make optical detector 10 every time, between sample rack 3 and optical detector 10 be equipped with by
The barn door 6 of motor driving rotation, barn door 6 is circular slab, and opaque, the shaft of barn door 6 is coaxial with sample rack 3, shading
The edge of plate 6, which is equipped with, only holds the loophole 7 that light beam injects optical detector 10, only a branch of every time by rotating sector 6
Optical signals optical detector 10 receives, and by controlling the velocity of rotation of barn door 6, can disposably be surveyed simultaneously to multiple samples
Examination.Passed through due to only holding a branch of optical signal every time, when barn door 6 rotates, when loophole 7 rotate to two-beam signal it
Between when, there are of short duration signal-less time, no signal point can be as the node for separating optical signal.
In order to be precisely controlled rotation position and the speed of barn door 6, to ensure to obtain more accurate, the barn door of optical signal
6 edges are equipped with signal teeth 8, and the position of preferred signals tooth 8 and the position of loophole 7 are located at the same side of barn door 6, and instrument is equipped with
The signal reader 9 of 8 signal of signal teeth is obtained, signal reader 9 exports 6 rotating speed of barn door and 7 position signal of loophole to meter
Calculation machine, motor are stepper motor, and computer exports rotary speed regulating signal to the driving circuit of motor, constitutes a closed-loop control electricity
Road ensures instrument work accurate stable.
It is numbered for the ease of distinguishing the corresponding sample chamber 4 of number that gets parms, instrument is equipped with handle 5 on sample rack 3,
Instrument is equipped with the cavity for placing sample rack 3, and cavity entrance is equipped with the groove for being embedded in handle 5, not only conveniently picks and places in this way,
Also the position that sample rack 3 is put into instrument, each all same can be accurately controlled, each sample chamber 4 is equipped with number, works as sample rack
3 when being put into instrument, one of them sample chamber 4 number opposite with 9 position of signal reader is 1, and sample chamber 4 is with barn door
6 direction of rotation serial numbers.First optical signal in this way when signal reader 9 gets the signal of signal teeth 8, which is numbered, is
1, then corresponding with the number of sample chamber 4, computer numbers subsequent optical signal sequence, since sample chamber 4 is rotated with barn door 6
Direction serial number, then the number of each optical signal is identical as the number of sample chamber 4.
In order to improve the accuracy of apparatus measures, the moment can monitor the operating mode of light source 1 and optical splitter 2, use instrument every time
When device, one of sample chamber 4 is vacant, and it is the optical detector 10 of not direct irradiation by sample to have a segment signal always in this way
On, optical detector 10 can be allowed directly to be detected to light source 1 and optical splitter 2, light beam is preset in computer and passes through vacant sample
The critical field value of optical detector 10 is irradiated to after this chamber 4, after instrument completes test, when and number constant there are a signal set
Value is in critical field value, then it represents that and it is working properly, otherwise illustrate 2 failure of light source 1 or optical splitter, this parameter measured is asked
Topic, can directly alarm, and user is allowed to know at the first time.
Control method based on accurate coagulation analysis instrument：
Sample rack 3 is put into instrument after putting samples into sample chamber 4, starts instrument later；
Instrument is rotated according to setting speed driving motor, when signal reader 9 detects signal teeth 8, as motor
The beginning to rotate a circle, when motor works, signal correction motor speed that instrument obtains in real time according to signal reader 9；
If sample chamber 4 is n, after motor often rotates a circle, the acquisition signal of optical detector 10 is divided into n parts, and according to
This number is 1,2,3 ... n；
Identical signal will be numbered every time to be stored together, and a certain volume is constituted according to the time sequencing continuous arrangement of acquisition
Number signal set；
Required blood parameters are obtained by computer according to the signal set of each number.
The present invention is exemplarily described above in conjunction with attached drawing, it is clear that the present invention implements not by aforesaid way
Limitation, as long as the improvement of the various unsubstantialities of inventive concept and technical scheme of the present invention progress is used, or without changing
Other occasions are directly applied to by the design of the present invention and technical solution, within protection scope of the present invention.
Claims (10)
1. accurate coagulation analysis instrument, instrument is equipped with the sample chamber for storing blood sample, and one end of the sample chamber is equipped with
The other end of light source, the sample chamber is equipped with optical detector, and the light that the light source is sent out passes through the blood sample in sample chamber
After inject optical detector, the photodetector output signal to computer, it is characterised in that：Instrument is equipped with taper type sample rack,
The angles such as the sample rack periphery are equipped at least two sample chambers, and the smaller one end of the sample rack is larger towards optical detector
One end towards optical splitter, the light that the light source projects projects light beam identical with sample chamber quantity, Mei Gesuo through optical splitter
It states light beam and is each passed through a sample chamber, the optical detector is located at the focal position of all light beams, and the sample rack is visited with light
It surveys between device equipped with the barn door by motor driving rotation, the shaft of the barn door is coaxial with sample rack, the barn door
Edge, which is equipped with, only holds the loophole that light beam injects optical detector.
2. accurate coagulation analysis instrument according to claim 1, it is characterised in that：The barn door edge is equipped with signal
Tooth, instrument are equipped with the signal reader for obtaining signal teeth signal, the signal reader output barn door rotating speed and loophole position
For confidence number to computer, the motor is stepper motor, and the computer exports rotary speed regulating signal to the driving circuit of motor.
3. accurate coagulation analysis instrument according to claim 1 or 2, it is characterised in that：When using instrument every time, wherein one
A sample chamber is vacant.
4. accurate coagulation analysis instrument according to claim 3, it is characterised in that：The sample rack is equipped with handle, institute
It states instrument and is equipped with the cavity for placing sample rack, the cavity entrance is equipped with the groove for being embedded in handle.
5. accurate coagulation analysis instrument according to claim 1 or 4, it is characterised in that：Each sample chamber is equipped with
Number, the position of the signal teeth and the position of loophole are located at the same side of barn door.
6. accurate coagulation analysis instrument according to claim 5, it is characterised in that：When sample rack is put into instrument,
One of them sample chamber number opposite with signal reader position is 1, and the sample chamber is compiled with barn door direction of rotation sequence
Number.
7. the control method based on accurate coagulation analysis instrument described in claim 1-6, it is characterised in that：
Sample rack is put into instrument after putting samples into sample chamber, starts instrument later；
Instrument is rotated according to setting speed driving motor；
If sample chamber is n, after motor often rotates a circle, optical detector acquisition signal is divided into n parts, and number is according to this
1、2、3…n；
Identical signal will be numbered every time to be stored together, and a certain number is constituted according to the time sequencing continuous arrangement of acquisition
Signal set；
Required blood parameters are obtained by computer according to the signal set of each number.
8. control method according to claim 7, it is characterised in that：When signal reader detects signal teeth, make
The beginning to rotate a circle for motor.
9. control method according to claim 8, it is characterised in that：When motor works, instrument is according to signal reader reality
When the signal correction motor speed that obtains.
10. according to the control method described in claim 7,8 or 9, it is characterised in that：At least one sample chamber is vacant, computer
It is inside preset with the critical field value that light beam is irradiated to optical detector after vacant sample chamber and works as presence after instrument completes test
One signal set is constant and numerical value is in critical field value, then it represents that and it is working properly, otherwise alarm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810129559.2A CN108344717A (en) | 2018-02-08 | 2018-02-08 | Accurate coagulation analysis instrument and its control method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810129559.2A CN108344717A (en) | 2018-02-08 | 2018-02-08 | Accurate coagulation analysis instrument and its control method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108344717A true CN108344717A (en) | 2018-07-31 |
Family
ID=62960106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810129559.2A Withdrawn CN108344717A (en) | 2018-02-08 | 2018-02-08 | Accurate coagulation analysis instrument and its control method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108344717A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109596816A (en) * | 2018-12-10 | 2019-04-09 | 海卫特(广州)医疗科技有限公司 | Sample setting time point confirms component and sample setting time point confirmation method |
| CN111208311A (en) * | 2018-11-22 | 2020-05-29 | 深圳迈瑞生物医疗电子股份有限公司 | Sample analysis assembly line, sample analysis control device and method |
-
2018
- 2018-02-08 CN CN201810129559.2A patent/CN108344717A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111208311A (en) * | 2018-11-22 | 2020-05-29 | 深圳迈瑞生物医疗电子股份有限公司 | Sample analysis assembly line, sample analysis control device and method |
| CN109596816A (en) * | 2018-12-10 | 2019-04-09 | 海卫特(广州)医疗科技有限公司 | Sample setting time point confirms component and sample setting time point confirmation method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5827746A (en) | Method to determine the sedimentation of blood and relative device | |
| CN101213437B (en) | Analyzer | |
| CN101126761B (en) | Blood coagulation analyzer and blood coagulation analyzing method | |
| JP5426937B2 (en) | Optical reaction measuring device and optical reaction measuring method | |
| US4000972A (en) | Measuring system for the pharmacological manipulation of the coagulation mechanism in blood and for the elapsed coagulation time | |
| DE2848552A1 (en) | METHOD FOR DETERMINING THE TIME OF COAGULATION OF BLOOD AND A DEVICE FOR CARRYING OUT THIS METHOD | |
| CN108344717A (en) | Accurate coagulation analysis instrument and its control method | |
| JP2007504468A (en) | Integrated apparatus and related methods for hematological analysis | |
| US9546981B2 (en) | Device and method for performing blood thromboelastographic assays by magnetic sensing | |
| CN108169178A (en) | A kind of smart machine for being used to be detected blood coagulation status and its control method | |
| CN207894827U (en) | Accurate coagulation analysis instrument | |
| CN106771108B (en) | Method and device for automatically acquiring thromboelastography | |
| CN207764125U (en) | A kind of smart machine for being detected to blood coagulation status | |
| US4452902A (en) | Method and equipment for the measurement of properties of a liquid | |
| CN108051604A (en) | A kind of coagulation time test method, apparatus and system | |
| CN107966578A (en) | A kind of medical quick biochemical detection system and detection method | |
| CN102551677B (en) | Endoscopic rotary probe used for diffuse optical tomography | |
| CN107271434A (en) | A kind of multifunctional medical detector and multifunctional medical detecting system | |
| RU2452936C2 (en) | Analyser for automatic determination of hemostatic profile | |
| CN210923714U (en) | Blood coagulation resistance detection device | |
| JPS6122253B2 (en) | ||
| JP2004286475A (en) | Apparatus for measuring glucose concentration | |
| USRE28009E (en) | Method for measuring the coagulation time of organic substances (and albuminoid | |
| JPS62228935A (en) | Automatic chemical analyzing instrument | |
| CN1117548C (en) | Woundless blood sugar measuring apparatus |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180731 |
|
| WW01 | Invention patent application withdrawn after publication |