CN108169178A - A kind of smart machine for being used to be detected blood coagulation status and its control method - Google Patents
A kind of smart machine for being used to be detected blood coagulation status and its control method Download PDFInfo
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- CN108169178A CN108169178A CN201810130260.9A CN201810130260A CN108169178A CN 108169178 A CN108169178 A CN 108169178A CN 201810130260 A CN201810130260 A CN 201810130260A CN 108169178 A CN108169178 A CN 108169178A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
- G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Present invention is disclosed a kind of smart machines for being detected to blood coagulation status, instrument is equipped with the sample chamber for storing blood sample, the optical detector that acquisition is come out light by sample chamber side-scattered is equipped with by the sample chamber, the photodetector output signal is to computer, the present invention is based on the scattered light urbidmetry blood coagulation analyzer technologies of existing maturation, by the fixed structure for changing sample, multiple samples can be analyzed simultaneously, and accuracy of measurement can be improved, it is smaller compared with existing product cost increase simultaneously, improve the working efficiency of analyzer.
Description
Technical field
The present invention relates to medical instrument more particularly to blood coagulation analyzers.
Background technology
Various composition content in blood of human body, quantitative biochemical analysis knot are measured on coaglation analyzer category medicinal
Fruit provides reliable digit foundation for the various diseases of clinical diagnosis patient, is clinical indispensable conventional detection apparatus.
Such as have the instrument that blood coagulation data are obtained using scattered light urbidmetry at present, according to sample to be detected in process of setting
The variation of middle scattering light determines detection terminal, in the method the monochromatic source of sense channel and light optical detector in 90 degree directly
Angular dependence, after coagulation activation agent is added in into sample, with the formation of fibrin clot in sample, the scattering light meeting of sample
It is stepped up, after sample solidifies completely, the intensity for scattering light no longer changes, and is used as 0% by the starting point solidified, solidification is eventually
Point is as 100%, and using 50% as setting time, optical detector receives this optical variation, converts it into electric signal, most
Parameter is taken by computer eventually.
But the instrument for obtaining blood coagulation data using scattered light urbidmetry at present can only once test a sample, working efficiency
It is low, and because only testing a sample every time, if light source etc. has exception, can not also know to break down quickly, so as to shadow
Ring the accuracy measured.
Invention content
The technical problems to be solved by the invention are to realize a kind of instrument that blood coagulation data are obtained using scattered light urbidmetry, energy
It is enough to measure multiple samples, and can guarantee the blood coagulation analyzer of measurement accuracy simultaneously.
To achieve these goals, the technical solution adopted by the present invention is：One kind is used to examine blood coagulation status
The smart machine of survey, instrument are equipped with the sample chamber for storing blood sample, and acquisition is equipped with by the sample chamber by sample chamber side
Area scattering comes out the optical detector of light, the photodetector output signal to computer, and instrument is equipped with the frustum of inner hollow
The angles such as shape sample rack, the sample rack periphery are equipped at least two sample chambers, and the side wall of each sample chamber offers
To the form of sample rack private side light transmission, each sample chamber is located at the larger one end of sample rack equipped with being put into the transparent appearance of sample
The entrance of device, each sample chamber are located at the smaller one end of sample rack equipped with light entrance port, the sample rack smaller one
End is equipped with optical splitter, and the light that light source projects projects the light beam identical with sample chamber quantity, each light beam point through optical splitter
By in light entrance port injection sample chamber, being set in the sample rack, there are one hollow taper type shading machines coaxially therewith
Structure, the chopping mechanism is driven by motor to be rotated, and the optical detector is stretched by chopping mechanism one end, the side of the chopping mechanism
Wall offers loophole, the loophole open up height and each form to open up height identical.
Described larger one end of chopping mechanism is towards the larger one end of sample rack, the frustum inclined-plane of the chopping mechanism and sample rack
Angle of inclination it is identical, the chopping mechanism is by side reflector and positioned at the reflective bottom plate at side reflector both ends and upper reflective
Annular slab is formed, and the medial surface of the side reflector, reflective bottom plate and upper reflective annular slab is the minute surface for reflection light,
The optical detector in the middle part of upper reflective annular slab by stretching into chopping mechanism.
For the motor by driving the center location of the reflective bottom plate of axis connection chopping mechanism, the drive shaft is equipped with signal
Tooth, instrument are equipped with the signal reader for obtaining signal teeth signal, the signal reader output chopping mechanism rotating speed and loophole
For position signal to computer, the motor is stepper motor, and the driving of the computer output speed Regulate signal to motor is electric
Road.
When using instrument every time, one of them described sample chamber is vacant.
The inlet of the transparent vessel of each sample chamber is equipped with number, the initial point position of the signal teeth and loophole
Position be located at the same side of drive shaft.
Sample chamber number right over signal reader is 1, and sample chamber is with chopping mechanism direction of rotation serial number.
It is a kind of based on the control method of smart machine for being detected to blood coagulation status：
After the transparent vessel that storage has sample is put into sample chamber, start instrument；
Instrument is rotated according to setting speed driving motor；
If sample chamber is n, after motor often rotates a circle, optical detector acquisition signal is divided into n parts, and compile according to this
Number be 1,2,3 ... n；
The signal for numbering identical every time is stored together, and a certain volume is formed according to the time sequencing continuous arrangement of acquisition
Number signal set；
Required blood parameters are obtained by computer according to the signal set of each number.
When signal reader detects signal teeth initial point position, the beginning that rotates a circle as motor.
When motor works, signal correction motor speed that instrument obtains in real time according to signal reader.
At least one sample chamber is vacant, and light beam is preset in computer across scattering light after vacant sample chamber to optical detection
The critical field value of device, after instrument completes test, when there are a signal set, constant and numerical value is in critical field value, then table
Show working properly, otherwise alarm.
The present invention is based on the scattered light urbidmetry blood coagulation analyzer technology of existing maturation, by changing the fixed structure of sample,
Multiple samples can be analyzed simultaneously, and can improve accuracy of measurement, while is smaller compared with existing product cost increase, improve analysis
The working efficiency of instrument.
Description of the drawings
The content of every width attached drawing expression in description of the invention and the label in figure are briefly described below：
Fig. 1 is the smart machine structure diagram for being detected to blood coagulation status；
Fig. 2 is chopping mechanism structure diagram in Fig. 1；
Label in above-mentioned figure is：1st, light source；2nd, optical splitter；3rd, sample rack；4th, sample chamber；5th, motor；6th, shading machine
Structure；7th, loophole；8th, signal teeth；9th, signal reader；10th, optical detector；11st, side reflector；12nd, reflective bottom plate；13rd, it is upper anti-
Light annular slab.
Specific embodiment
The operation principle of instrument is believed light by optical detector 10 using conventional scattered light urbidmetry blood coagulation analyzer technology
Number electric signal is converted into, then these electric signals are delivered to computer, parameter, such as blood clotting as needed for obtaining computer analysis
Time, computer include at least processing unit, display device, storage device.
Instrument sets the sample rack 3 there are one taper type, is hollow structure, and the sample chamber 4 for storing blood is arranged on sample
The periphery of this 3, sample chamber 4 wait angles setting each other, and each angle of inclination is identical is set each along 3 inclined-plane of sample rack
It puts, each sample chamber 4 is located at the larger one end of sample rack 3 and is equipped with the entrance for being put into sample transparent vessel, and each sample chamber 4 is located at
3 smaller one end of sample rack is equipped with light entrance port, after sample (blood) is by being placed in transparent vessel (such as test tube), is put into
Into sample chamber 4,4 inner wall of sample chamber is impermeable photo structure, and it is saturating only to open up oriented 3 private side of sample rack in the side wall of sample chamber 4
The form of light, each form is opened up positioned at 3 bottom surface of distance sample frame or top apart from all same, i.e., positioned at identical height
Position, sample chamber 4 at least set two, are preferably provided with 6-10, then can measure multiple samples simultaneously.
The light that light source 1 projects projects the light beam identical with 4 quantity of sample chamber, the brightness phase of each light beam through optical splitter 2
Together, optical splitter 2 passes through light incidence respectively using the conventional device that light beam decile can be divided into multi beam, each light beam
Mouth is injected in sample chamber 4, and the scattering light that the light beam in each sample chamber 4 is radiated on sample has form to be irradiated to sample rack 3
It is interior.
In order to make optical detector 10 that can only receive the scattering light in a sample chamber 4 every time, set in sample rack 3 there are one
Hollow taper type chopping mechanism 6 coaxially therewith, 6 larger one end of chopping mechanism is towards 3 larger one end of sample rack, chopping mechanism 6
Identical with the angle of inclination on the frustum inclined-plane of sample rack 3, chopping mechanism 6 is by side reflector 11 and positioned at 11 liang of side reflector
The reflective bottom plate 12 and upper reflective annular slab 13 at end are formed, and optical detector 10 stretches into chopping mechanism by upper reflective 13 middle part of annular slab
In 6.
Chopping mechanism 6 drives rotation by motor 5, loophole 7 open up height and each form to open up height identical, and
And any angle no matter is rotated to, loophole 7 only intersects with a form, avoids the light of two forms while inject to cause shadow
It rings, by rotating chopping mechanism 6, only a branch of scattered light signal is received by optical detector 10 every time, by controlling chopping mechanism 6
Velocity of rotation, disposably multiple samples can be tested simultaneously.Shading machine is injected due to only holding a branch of scattered light signal every time
In structure 6, therefore when chopping mechanism 6 rotates, when the position between loophole 7 rotates to two forms, there are of short duration nothings
Optical signal time, unglazed signaling point can be as the nodes for separating optical signal.
In order to improve the sensitivity for obtaining scattering light, side reflector 11, reflective bottom plate 12 and upper reflective annular slab 13 it is interior
Side is the minute surface for reflection light, when some form intersects with loophole 7, after the light of scattering enters loophole 7
It can be radiated on reflective annular slab 13, then reflex to reflective bottom plate 12, finally inject in optical detector 10.
In order to be precisely controlled the rotation position of barn door and speed, so as to ensure to obtain the more accurate of optical signal, motor 5 is logical
The center location of 6 reflective bottom plate 12 of axis connection of overdriving chopping mechanism, drive shaft are equipped with signal teeth 8, and instrument, which is equipped with to obtain, to be believed
The signal reader 9 of number 8 signal of tooth, signal reader 9 export 6 rotating speed of chopping mechanism and 7 position signal of loophole to computer,
Motor 5 is stepper motor 5, and the driving circuit of computer output speed Regulate signal to motor 5 forms a closed-loop control electricity
Road ensures instrument work accurate stable.
It is numbered for the ease of distinguishing the corresponding sample chamber 4 of number that gets parms, the transparent vessel of each sample chamber 4 enters
Number is equipped at mouthful, the initial point position of signal teeth 8 and the position of loophole 7 are located at the same side of drive shaft, positioned at signal-obtaining
The number of sample chamber 4 right over device 9 is 1, and sample chamber 4 works as signal reader in this way with 6 direction of rotation serial number of chopping mechanism
9 first optical signal number when getting the initial point position signal of signal teeth 8 is 1, then corresponding with the number of sample chamber 4,
Computer numbers subsequent optical signal sequence, since sample chamber 4 is with barn door direction of rotation serial number, then each optical signal
Number is identical with the number of sample chamber 4.
In order to improve the accuracy of apparatus measures, the moment can monitor the operating mode of light source 1 and optical splitter 2, every time using instrument
During device, one of sample chamber 4 is vacant, and it is the optical detector 10 not scattered directly by sample to have a segment signal always in this way
On, optical detector 10 can be allowed to directly acquire the optical signal that light source 1 and optical splitter 2 are sent out, sample is eliminated and interfere, in computer
Light beam is preset with across the critical field value that optical detector 10 is scattered to after vacant sample chamber 4, after instrument completes test, works as presence
One signal set is constant and numerical value is in critical field value, then it represents that and it is working properly, otherwise illustrate 2 event of light source 1 or optical splitter
Barrier, the parameter that this is measured is problematic, can directly alarm, and user is allowed to know at the first time.
Based on for the control method for the smart machine being detected to blood coagulation status：
After the transparent vessel that storage has sample is put into sample chamber 4, start instrument；
Instrument is rotated according to setting speed driving motor 5, and when motor 5 works, instrument obtains in real time according to signal reader 9
5 rotating speed of signal correction motor；
When signal reader 9 detects 8 initial point position of signal teeth, as the beginning that motor 5 rotates a circle, if sample
Chamber 4 is n, then after motor 5 often rotates a circle, optical detector 10 is obtained signal and is divided into n part, and to number according to this be 1,2,
3…n；
The signal for numbering identical every time is stored together, and a certain volume is formed according to the time sequencing continuous arrangement of acquisition
Number signal set；
Required blood parameters are obtained by computer according to the signal set of each number.
At least one sample chamber 4 is vacant, and light beam is preset in computer and is visited across scattering light after vacant sample chamber 4 to light
Survey device 10 critical field value, instrument complete test after, when there are a signal set constant and numerical value in critical field value,
It then represents working properly, otherwise alarms.
The present invention is exemplarily described above in conjunction with attached drawing, it is clear that present invention specific implementation is not by aforesaid way
Limitation, as long as employ the inventive concept and technical scheme of the present invention progress various unsubstantialities improvement or without changing
Other occasions are directly applied to by the design of the present invention and technical solution, within protection scope of the present invention.
Claims (10)
1. a kind of smart machine for being detected to blood coagulation status, instrument is equipped with the sample for storing blood sample
Chamber, the sample chamber side are equipped with the optical detector that acquisition is come out light by sample chamber side-scattered, the optical detector output letter
Number to computer, it is characterised in that：Instrument is equipped with the angles such as the taper type sample rack of inner hollow, the sample rack periphery and is equipped with
At least two sample chambers, the side wall of each sample chamber opens up the form of oriented sample rack private side light transmission, each described
Sample chamber is located at the larger one end of sample rack and is equipped with the entrance for being put into sample transparent vessel, and each sample chamber is located at sample rack
Smaller one end is equipped with light entrance port, and described smaller one end of sample rack is equipped with optical splitter, and the light that light source projects is through light splitting
Device projects the light beam identical with sample chamber quantity, and each light beam is injected by light entrance port in sample chamber respectively, described
It is set in sample rack there are one hollow taper type chopping mechanism coaxially therewith, the chopping mechanism is driven by motor to be rotated, described
Optical detector is stretched by chopping mechanism one end, and the side wall of the chopping mechanism offers loophole, and the loophole opens up height
Spend with each form to open up height identical.
2. the smart machine according to claim 1 for being detected to blood coagulation status, it is characterised in that：It is described
The larger one end of chopping mechanism is towards the larger one end of sample rack, the angle of inclination phase on the frustum inclined-plane of the chopping mechanism and sample rack
Together, reflective bottom plate and upper reflective annular slab of the chopping mechanism by side reflector and positioned at side reflector both ends are formed, institute
The medial surface for stating side reflector, reflective bottom plate and upper reflective annular slab is the minute surface for reflection light, the optical detector
By being stretched into chopping mechanism in the middle part of upper reflective annular slab.
3. the smart machine according to claim 1 or 2 for being detected to blood coagulation status, it is characterised in that：
For the motor by driving the center location of the reflective bottom plate of axis connection chopping mechanism, the drive shaft is equipped with signal teeth, instrument
Equipped with the signal reader for obtaining signal teeth signal, the signal reader output chopping mechanism rotating speed and loophole position signal
To computer, the motor be stepper motor, the driving circuit of the computer output speed Regulate signal to motor.
4. the smart machine according to claim 3 for being detected to blood coagulation status, it is characterised in that：Every time
During using instrument, one of them described sample chamber is vacant.
5. the smart machine according to claim 4 for being detected to blood coagulation status, it is characterised in that：Each
The inlet of the transparent vessel of the sample chamber is equipped with number, and the initial point position of the signal teeth and the position of loophole, which are located at, drives
The same side of moving axis.
6. the smart machine according to claim 5 for being detected to blood coagulation status, it is characterised in that：It is located at
Sample chamber number right over signal reader is 1, and sample chamber is with chopping mechanism direction of rotation serial number.
It is 7. a kind of based on the controlling party of smart machine for being used to be detected blood coagulation status as described in claim 1-6
Method, it is characterised in that：
After the transparent vessel that storage has sample is put into sample chamber, start instrument；
Instrument is rotated according to setting speed driving motor；
If sample chamber is n, after motor often rotates a circle, optical detector acquisition signal is divided into n parts, and number is according to this
1、2、3…n；
The signal for numbering identical every time is stored together, and a certain number is formed according to the time sequencing continuous arrangement of acquisition
Signal set；
Required blood parameters are obtained by computer according to the signal set of each number.
8. control method according to claim 7, it is characterised in that：Whenever signal reader detects signal teeth initial point position
When putting, the beginning that rotates a circle as motor.
9. control method according to claim 8, it is characterised in that：When motor works, instrument is according to signal reader reality
When the signal correction motor speed that obtains.
10. according to the control method described in claim 7,8 or 9, it is characterised in that：At least one sample chamber is vacant, computer
Critical field value of the light beam across scattering light after vacant sample chamber to optical detector is inside preset with, after instrument completes test, when
There are a signal set, constant and numerical value is in critical field value, then it represents that and it is working properly, otherwise alarm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810130260.9A CN108169178A (en) | 2018-02-08 | 2018-02-08 | A kind of smart machine for being used to be detected blood coagulation status and its control method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810130260.9A CN108169178A (en) | 2018-02-08 | 2018-02-08 | A kind of smart machine for being used to be detected blood coagulation status and its control method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108169178A true CN108169178A (en) | 2018-06-15 |
Family
ID=62513839
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810130260.9A Withdrawn CN108169178A (en) | 2018-02-08 | 2018-02-08 | A kind of smart machine for being used to be detected blood coagulation status and its control method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108169178A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109596816A (en) * | 2018-12-10 | 2019-04-09 | 海卫特(广州)医疗科技有限公司 | Sample setting time point confirms component and sample setting time point confirmation method |
| CN115813527A (en) * | 2023-01-17 | 2023-03-21 | 湖南轶疆医疗科技有限公司 | Surgical hemostasis device for artificial limb operation |
-
2018
- 2018-02-08 CN CN201810130260.9A patent/CN108169178A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109596816A (en) * | 2018-12-10 | 2019-04-09 | 海卫特(广州)医疗科技有限公司 | Sample setting time point confirms component and sample setting time point confirmation method |
| CN115813527A (en) * | 2023-01-17 | 2023-03-21 | 湖南轶疆医疗科技有限公司 | Surgical hemostasis device for artificial limb operation |
| CN115813527B (en) * | 2023-01-17 | 2023-05-12 | 湖南轶疆医疗科技有限公司 | Surgical hemostatic device for artificial limb operation |
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Application publication date: 20180615 |