CN108341871A - 抗pd-1单克隆抗体及其制备方法和应用 - Google Patents

抗pd-1单克隆抗体及其制备方法和应用 Download PDF

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Publication number
CN108341871A
CN108341871A CN201710054783.5A CN201710054783A CN108341871A CN 108341871 A CN108341871 A CN 108341871A CN 201710054783 A CN201710054783 A CN 201710054783A CN 108341871 A CN108341871 A CN 108341871A
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ser
seq
human
monoclonal antibody
val
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赵杰
高宏海
郭锦林
党尉
朱玲巧
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Three Country Kin Pharmaceutical (shanghai) Ltd By Share Ltd
Sunshine Guojian Pharmaceutical Shanghai Co Ltd
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Three Country Kin Pharmaceutical (shanghai) Ltd By Share Ltd
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Priority to CN201710054783.5A priority Critical patent/CN108341871A/zh
Priority to CN201880007287.7A priority patent/CN110225928B/zh
Priority to EP18745412.9A priority patent/EP3575322B1/en
Priority to PCT/CN2018/073575 priority patent/WO2018137576A1/zh
Priority to US16/480,014 priority patent/US11254746B2/en
Priority to JP2019536981A priority patent/JP7098629B2/ja
Publication of CN108341871A publication Critical patent/CN108341871A/zh
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • A61P37/00Drugs for immunological or allergic disorders
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    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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CN201710054783.5A 2017-01-24 2017-01-24 抗pd-1单克隆抗体及其制备方法和应用 Pending CN108341871A (zh)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN201710054783.5A CN108341871A (zh) 2017-01-24 2017-01-24 抗pd-1单克隆抗体及其制备方法和应用
CN201880007287.7A CN110225928B (zh) 2017-01-24 2018-01-22 抗pd-1单克隆抗体及其制备方法和应用
EP18745412.9A EP3575322B1 (en) 2017-01-24 2018-01-22 Anti-pd-1 monoclonal antibody, and preparation method therefor and application thereof
PCT/CN2018/073575 WO2018137576A1 (zh) 2017-01-24 2018-01-22 抗pd-1单克隆抗体及其制备方法和应用
US16/480,014 US11254746B2 (en) 2017-01-24 2018-01-22 Anti-PD-1 monoclonal antibody, and preparation method therefor and application thereof
JP2019536981A JP7098629B2 (ja) 2017-01-24 2018-01-22 抗pd-1モノクローナル抗体、その製造方法及び用途

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US (1) US11254746B2 (enExample)
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WO (1) WO2018137576A1 (enExample)

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CN109748965A (zh) * 2019-03-13 2019-05-14 安徽安科生物工程(集团)股份有限公司 全人源pd-l1单克隆抗体及其制备方法和应用
CN109929037A (zh) * 2019-04-01 2019-06-25 华博生物医药技术(上海)有限公司 针对程序性死亡配体的结合物及其应用
CN110563849A (zh) * 2019-08-09 2019-12-13 安徽瀚海博兴生物技术有限公司 一种全新序列的抗vegf-抗pd1双特异性抗体
CN111196855A (zh) * 2018-11-19 2020-05-26 三生国健药业(上海)股份有限公司 抗egfr/pd-1双特异性抗体
WO2020103629A1 (zh) * 2018-11-19 2020-05-28 三生国健药业(上海)股份有限公司 抗her2/pd1双特异性抗体
WO2020156222A1 (zh) * 2019-02-01 2020-08-06 长春金赛药业有限责任公司 人源化抗Aβ单克隆抗体及其应用
CN113150154A (zh) * 2021-04-15 2021-07-23 博奥信生物技术(南京)有限公司 抗人pdl1单克隆抗体及其用途
WO2021249551A1 (zh) * 2020-06-11 2021-12-16 三生国健药业(上海)股份有限公司 一种抗pd-1单克隆抗体液体制剂
WO2022068891A1 (zh) * 2020-09-30 2022-04-07 苏州沙砾生物科技有限公司 Pd-1抗体及其制备方法与应用
CN114316047A (zh) * 2021-01-14 2022-04-12 东大生物技术(苏州)有限公司 一组pd-1单克隆抗体及其医药用途
CN114539407A (zh) * 2021-12-31 2022-05-27 浙江大学 一种全人源抗PD-1的单克隆抗体No.1-10及其应用
CN114539406A (zh) * 2021-12-31 2022-05-27 浙江大学 一种全人源抗PD-1的单克隆抗体No.8-3及其应用

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CN113563473A (zh) 2020-04-29 2021-10-29 三生国健药业(上海)股份有限公司 四价双特异性抗体、其制备方法和用途
WO2021226984A1 (zh) * 2020-05-15 2021-11-18 三生国健药业(上海)股份有限公司 一种抗pd-1和pd-l1的四价双特异性抗体
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CN113754767A (zh) * 2020-06-03 2021-12-07 上海恒润达生生物科技股份有限公司 抗人pd-1抗体及其用途
CN111647624A (zh) * 2020-06-10 2020-09-11 成都和同易创生物科技有限公司 Tsab人源单克隆抗体重组载体、重组抗体及其制备方法
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CN113980129B (zh) * 2021-01-15 2023-07-28 东大生物技术(苏州)有限公司 一组il-11单克隆抗体及其医药用途
CN115536749A (zh) * 2021-06-29 2022-12-30 三生国健药业(上海)股份有限公司 三特异性抗体、其制备方法和用途
JP2025518812A (ja) * 2022-06-01 2025-06-19 シンクロミューン・インコーポレイテッド 腫瘍細胞溶解、及び免疫療法成分の組み合わせの腫瘍内投与によるがんを処置するための方法
CN115925947B (zh) * 2022-09-27 2023-08-22 上海百英生物科技股份有限公司 一种亲和力成熟方法及抗人pd-l1单域抗体的亲和力成熟
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WO2020103629A1 (zh) * 2018-11-19 2020-05-28 三生国健药业(上海)股份有限公司 抗her2/pd1双特异性抗体
CN111196855B (zh) * 2018-11-19 2022-11-15 三生国健药业(上海)股份有限公司 抗egfr/pd-1双特异性抗体
US12384853B2 (en) 2018-11-19 2025-08-12 Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. Anti-HER2/PD1 bispecific antibody
CN111196855A (zh) * 2018-11-19 2020-05-26 三生国健药业(上海)股份有限公司 抗egfr/pd-1双特异性抗体
WO2020156222A1 (zh) * 2019-02-01 2020-08-06 长春金赛药业有限责任公司 人源化抗Aβ单克隆抗体及其应用
US12258386B2 (en) 2019-02-01 2025-03-25 Changchun Genescience Pharmaceutical Co., Ltd. Humanized anti-A β monoclonal antibody and application thereof
CN109748965A (zh) * 2019-03-13 2019-05-14 安徽安科生物工程(集团)股份有限公司 全人源pd-l1单克隆抗体及其制备方法和应用
CN109929037B (zh) * 2019-04-01 2023-03-17 华博生物医药技术(上海)有限公司 针对程序性死亡配体的结合物及其应用
CN109929037A (zh) * 2019-04-01 2019-06-25 华博生物医药技术(上海)有限公司 针对程序性死亡配体的结合物及其应用
CN110563849B (zh) * 2019-08-09 2022-09-09 安徽瀚海博兴生物技术有限公司 一种抗vegf-抗pd1双特异性抗体
CN110563849A (zh) * 2019-08-09 2019-12-13 安徽瀚海博兴生物技术有限公司 一种全新序列的抗vegf-抗pd1双特异性抗体
CN115803055A (zh) * 2020-06-11 2023-03-14 三生国健药业(上海)股份有限公司 一种抗pd-1单克隆抗体液体制剂
WO2021249551A1 (zh) * 2020-06-11 2021-12-16 三生国健药业(上海)股份有限公司 一种抗pd-1单克隆抗体液体制剂
CN114761434A (zh) * 2020-09-30 2022-07-15 苏州沙砾生物科技有限公司 Pd-1抗体及其制备方法与应用
CN114761434B (zh) * 2020-09-30 2023-06-27 苏州沙砾生物科技有限公司 Pd-1抗体及其制备方法与应用
WO2022068891A1 (zh) * 2020-09-30 2022-04-07 苏州沙砾生物科技有限公司 Pd-1抗体及其制备方法与应用
CN114316047A (zh) * 2021-01-14 2022-04-12 东大生物技术(苏州)有限公司 一组pd-1单克隆抗体及其医药用途
CN114316047B (zh) * 2021-01-14 2023-12-22 东大生物技术(苏州)有限公司 一组pd-1单克隆抗体及其医药用途
CN113150154B (zh) * 2021-04-15 2022-05-10 博奥信生物技术(南京)有限公司 抗人pdl1单克隆抗体及其用途
CN113150154A (zh) * 2021-04-15 2021-07-23 博奥信生物技术(南京)有限公司 抗人pdl1单克隆抗体及其用途
CN114539406A (zh) * 2021-12-31 2022-05-27 浙江大学 一种全人源抗PD-1的单克隆抗体No.8-3及其应用
CN114539407B (zh) * 2021-12-31 2023-04-18 浙江大学 一种全人源抗PD-1的单克隆抗体No.1-10及其应用
CN114539406B (zh) * 2021-12-31 2023-04-14 浙江大学 一种全人源抗PD-1的单克隆抗体No.8-3及其应用
CN114539407A (zh) * 2021-12-31 2022-05-27 浙江大学 一种全人源抗PD-1的单克隆抗体No.1-10及其应用

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