CN108333176A - A kind of system and method for mobile terminal quantitative analysis dry chemical detection strip - Google Patents
A kind of system and method for mobile terminal quantitative analysis dry chemical detection strip Download PDFInfo
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- CN108333176A CN108333176A CN201810121209.1A CN201810121209A CN108333176A CN 108333176 A CN108333176 A CN 108333176A CN 201810121209 A CN201810121209 A CN 201810121209A CN 108333176 A CN108333176 A CN 108333176A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/8483—Investigating reagent band
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/02—Mechanical
- G01N2201/022—Casings
- G01N2201/0221—Portable; cableless; compact; hand-held
Abstract
The present invention discloses a kind of system and method for mobile terminal quantitative analysis dry chemical detection strip, include application module including detection strip and mobile terminal, the mobile terminal, the application module includes, image acquisition units carry out image taking to the detection strip；Image processing unit, the image noise reduction deblurring to image acquisition units shooting and extraction color edges line；Concentration computing unit establishes concentration curve, and calculates sample concentration value；Length of the concentration computing unit to detect strip establishes concentration curve as X-axis using sample concentration value as Y-axis；Weighted average of the color edges line that image processing unit is read in X-coordinate axle finds Y value corresponding with the X values as X values, according to concentration curve, and Y value is the concentration value of sample.The method of the present invention is simple and convenient to operate, is not necessarily to external equipment, you can quantitative analysis detects the concentration of strip.
Description
Technical field
The present invention relates to the system and method that a kind of quantitative analysis dry chemical detects strip, and in particular to a kind of mobile terminal
The system and method that quantitative analysis dry chemical detects strip.
Background technology
Concern of the people to own health safety and living environment be unable to do without the support of analytical control, including medical treatment is faced
Bed examines, food safety detection and environmental quality detection etc., these analysis detections are from the pervious method tested by hand court
It full-automatic, intelligent and Site Detection direction to develop, dramatically reduces the work load of analysis operation personnel.
Care diagnostic is quickly grown in recent years as a kind of field quick detection technology.So-called care diagnostic refers in disease
Personal other rapid acquisition testing result.The technology is convenient and efficient, does not depend on the technology of expensive experimental instrument and equipment or profession
Personnel are also not required to, by complicated sample handling procedure, greatly facilitate analysis operation.
Analytical control can be divided into two methods of liquid reagent and dry chemistry reagent by analytical reagent type.It is tried using liquid
Agent（Wet-chemical）Method can obtain more satisfied accuracy and precision, but need expensive instrument and professional technician,
And it is cumbersome, cannot quickly determine as a result, be not suitable for field test, such as the detection of hospital emergency rooms and small lot sample
Demand.And dry chemistry reagent it is easy to operate with its, measure fast and flexible and without professional person the advantages that, can mend well
The shortcoming of wet chemistry method, accuracy of measurement and precision have been filled already close to wet chemical determination method, wherein especially with dry
Chemical detection strip is widely used in the fields such as clinical examination, food safety detection, environmental quality detection, provides greatly
It is convenient.It is that in contrast, it is to be detected the liquid in sample as reaction that " dry chemical ", which is with traditional " wet-chemical ",
Medium, a kind of mode that determinand is directly reacted with solidification in the powdered reagent on carrier.The maximum area of it and conventional wet chemical
It is not that the medium for participating in chemical reaction is different, reagent some or all of needed for reaction is fixed on special knot in advance
In the carrier of structure, determinand is caused to occur to chemically react and generate reaction signal with the reagent in carrier, finally by visually fixed
Property, semi-quantitative analysis or by portable instrument quantitative analysis, to measure the concentration of determinand in sample.With biochemistry
The development of the technologies such as separation, purification and the storage of middle enzyme, sensor, the progress of photometer and electrode technology and computer are answered
Universal, dry chemical technology has obtained significant progress in nearly 20 years.Dry analysis is micro sensitive, simple, fast because of its
Speed, in real time, the advantages that field diagnostic can be done, is widely applicable, especially meet the requirement of care diagnostic technology, be suitble to base's detection and
The demands such as large area generaI investigation, have huge development potentiality and wide application prospect.
However, that there is resolution ratio is low, qualitative can only cannot quantify, testing result relies on behaviour for the direct visual analysis of dry chemical
The subjective experience of author, detection are with very big subjectivity, False Rate is higher, testing result can only hand-kept, not easy to maintain, only
The drawbacks such as use suitable for professional.Due to the precise requirements continuous improvement to detection and analysis, this is just required to provide
The new solution of one quantitative data.With advances in technology, the method for traditional result by visual observation is just gradually made
It is replaced with instrument and equipment reading, the shadow that result avoids artificial subjective factor to a certain extent is read using instrument and equipment
It rings, so that testing result is more accurate.Strip quantitative detecting method based on image procossing attracts attention extensively, becomes and obtains
Take the effective ways of quantitative result data.The acquisition of strip image is generally by special CCD or cmos image sensor, then
The processing of next step is carried out using personal computer or the processor of costliness, this method affects portability and practicability,
Good support cannot be provided to Site Detection.
With the fast development of electronic information, people can carry out message reference, wherein intelligence in many ways whenever and wherever possible
Energy mobile phone is one of most common method, and many researchs record the colour developing areas of test paper using smart mobile phone, camera or scanner
Domain, then analyze with Aobe Photoshop the color of color development area, be rapidly completed data acquisition, signal processing, data analysis and
Acquisition conclusion and etc..This method is to obtain test paper image by imaging sensor, is used based on image measurement principle
Software captures the colouring information of test paper, using data statistic analysis and interpretation image, obtains quantitative testing result.
Care diagnostic technology based on smart mobile phone causes extensive concern, is the hot topic of lot of domestic and foreign scientific research institution
Research topic.Such as a kind of patent " intelligence inspections doing harm to substance for the fast inspection water intoxication of taking photograph of intelligent mobile phone imaging of CN206270246U
Water light box ", " system and detection method of a kind of field quick detection catechols of CN201610122771.7 and its derivative ",
" CN201380058363.4 collects the device and method measured for biomolecule reflecting point ", " CN104730265B hand-helds
POCT streamings gene alaysis system ", " molecular intelligence mobile phones of the CN201610914030.2 based on dominant wavelength and complementary wavelength
Fast determining method ", " a kind of minisize capillary pipe luminoscopes of CN201610981565.1 " and " CN102165321B for detect biology and
The disposable hand-held diagnostic detection device and related system and method for environment measuring sample " is used as inspection using smart mobile phone
Good try has been done in the research of the signal acquiring system of measurement equipment.Although the resolution ratio of imaging sensor divides test paper image
Analysis precision has some influences, but this method because have it is of low cost, easy to operate, detect the advantages such as quick, easy to carry,
It has been to be concerned by more and more people.
Smart mobile phone is used in detection and analysis research work, be by photographing function of mobile phone, obtain true image and
Image information is handled.And mobile phone camera takes pictures to obtain the quality of picture, it will face external environment light, and not
With the time for exposure of mobile phone, exposure rate, sensitivity, the influence of the factor of focal length also suffers from the position of smart mobile phone camera
With the great influence of angle.For this purpose, thering is research team to develop corollary apparatus, to exclude these disturbing factors, to obtain height
The digital image information of quality.Such as a kind of patent " food safety detection dresses based on intelligent mobile terminal of CN205982094U
Set ", " a kind of immunochromatography chip quantified system analysis based on smart mobile phone of CN201710305207.3 " and
Specially design can fix mobile phone in " discoloration diagnosis test paper quantitative imaging systems of the CN201610707152.4 based on mobile terminal "
With the device of strip, and in a device distribution light source to avoid ambient light interference.As " CN201710541399.8 is a kind of for patent
The detection method of the tumour correlation specific antigen of rapid qualitative informationization, detection device and preparation method thereof " to mobile phone by adding
Dress can fix the simple plastics deck of strip, and raising mobile phone takes pictures effect to strip.
How to Image Information Processing, therefrom read the content of sample, many research teams with color of image analysis means,
Realize reading to data, as patent " devices of the CN201480017254.2 based on smart mobile phone and for obtaining it is repeatable
The method that Quantitative colorimetric measures ", tone-saturation degree-lightness (HSL) color is converted by the collected RGB color system of mobile phone
The signal of system, the tone value of HSL color systems and the pH value of conventional universal indicator material change in approximately linear, to reach
To quantitative effect；Such as patent " diagnostic test of PCT/US2012/064856 paper substrates ", pass through the image face in mobile phone collecting test area
Color；Software processing interpretation converts images into RGB, HSV or CMYK color body using normalized color intensity value as basis for estimation
System, reads required system color component（Such as the R in RGB systems, a certain component in G, B）, bent according to color component standard
Line is quantitative to realize；Patent " a kind of cysteine detecting methods based on mobile phone color analysis of CN201610031888.4 ",
" a kind of methods that metal ion is detected based on smart mobile phone rapid field of CN201510508573.X ", " CN105181959B mono-
Kind of immunity-chromatography test strip quantitative testing device and method " and " CN103954751B paper substrate micro-fluidic immunosensor chips and show
Immunoassay platform is detected in time in field " also using the processing method of similar color component, as shown in Figure 3.
A kind of patent " electrochemical luminescence biochemical detection systems based on mobile phone USB-OTG interfaces of CN201710116895.9
And method " and " a kind of methods of mobile terminal quantitative analysis dry chemical detection reagent of CN201610051775.0 " be to adopt mobile phone
The colouring information collected does gray proces, and standard curve is done according to gray value, handles the gray value of sample to quantify.
Above research is to carry out different disposal to colouring information to obtain quantitative value, this is just to the image matter for acquisition of taking pictures
Amount has strict requirements, and indices carry out specification, including dedicated corollary equipment and lighting conditions when needing to taking pictures, also
To mobile phone shooting angle, distance and the requirement of time for exposure, to obtain the image information of high quality.When necessary, it needs with ginseng
Mobile phone respective difference when the Standard colour board examined is taken pictures with deducting.Using such treatment technology, need to solve for the back of the body of not sharing the same light
The distortion for the color that scape is brought, while the color of sample itself can also bring no small influence to detection.
Meanwhile also having different research methods in detection and analysis technology seeking smart mobile phone, wherein no longer acquisition figure
The colouring information of picture, and by the prior pattern handling to chip, it can cause to analyze the figure shown on front and back chip
Change in shape analyzes graphics process, to realize the purpose quickly detected.The identification technology of existing bar code and Quick Response Code at
It is ripe, by the Technology application of bar code and Quick Response Code in detection and analysis, the information that includes bar code or Quick Response Code convenient for mobile phone
It is processed into digital information.Such as a kind of patent " residues of organophosphate pesticides based on smart mobile phone bar code readable style of CN104359904 B
Detection method " and " biological rapid detection methods of the CN201610863598.6 based on smart phone two-dimensional code style " are exactly to pass through
Microchannel is etched on chip is respectively formed bar code and Quick Response Code shape, after the sample of different content reacts on chip, meeting
Different bar codes or Quick Response Code shape information are formed, the content of sample is obtained by the deciphering of mobile phone.However, technique pair
The microchannel requirement on machining accuracy of chip is high, and cost is higher, while can only be to the content sample detection of a certain range.
Above-mentioned smart mobile phone color treatments analysis method and graphics process analysis method generally require external corollary equipment, together
When color processing method be not easy eliminate sample itself color interference；The cost of graphics process analysis method is higher and cannot be complete
It is used for quantitative analysis entirely, becomes the factor that mobile phone quickly detects application at the scene that restricts.
Using a kind of interference being avoided that sample itself color of mobile terminal design, it is not necessarily to external equipment, can quantify and divide
The method for analysing dry chemical detection reagent just becomes the key of the present invention.
Color treatments analysis method is the absolute value of the color of acquisition, the reason of needing external equipment here it is the method,
The reason of being also the interference of sample itself color, this is equivalent to Distortion course of the analog signal in processing procedure in circuit.
Graphics process analysis method is equivalent to the processing of digital signal in circuit, avoids Distortion course；It is analyzed relative to color treatments
Method, it includes information it is few, that is, the reason of quantitative analysis cannot be entirely used for.Using the processing similar to digital signal
And include the processing analysis method of bulk information, it is the main thought of the present invention.
In visual analyzing research, research is that the concentration information of sample is changed into the method for distance signal, sample
Content it is related at a distance from the colour developing of chip or test paper, pass through the develop the color length of distance of reading and obtain the content of sample.Such as text
Offer " Microfluidic Distance Readout Sweet Hydrogel Integrated Paper-based
Analytical Device (μ DiSH-PAD) for Visual Quantitative Point-of-Care Testing, "
With patent " a kind of 3D of CN201710670159.8 integrate paper chip and visualization Quantitative detection target method ", pass through reaction
Product lateral flow diffusion colour developing on the channel of paper chip, shows the range information of color, to reflect the content of sample；
Here colour developing is only on the channel of paper chip.Patent " multilayer film dry chemical detections of the CN105021596B based on concentration gradient
Strip " be by by titrant with the distribution of concentration gradient.Set up the titration quantitative model on solid phase carrier, the shape in strip
At two color regions, sample size can be obtained by reading location information of the color change point in strip, and here it is can determine
The solution of amount analysis detection sample.This quantitative scheme, due to forming two color regions, colour system is arrived in reflection
On component, will there are one or two color components in the suddenly change of catastrophe point position, be relative quantity, including digital quantity
Information, easily readable and processing, this facilitate that smart mobile phone works, simultaneously as being relative quantity, the color interference of sample can
To exclude, the background of ambient light does not interfere with as a result, to not be additionally required external equipment, and being fully achieved only need to use mobile phone and examination
Item can be achieved with the purpose of live fast quantitative analysis detection.
For the development of internet industry, the detection device based on intelligent platform is increasingly becoming the hot spot of research and development, major
Internet company is laid out internet medical treatment development, is an important direction using smart mobile phone as mobile detection terminal, can be directly
Using mobile phone as detection device, great convenience is brought to Site Detection, the use of layman, expansion can more be facilitated to answer
With field, also data basis is provided for the cloud computing of analysis detecting data.
Invention content
Goal of the invention：Present invention aims in view of the deficiencies of the prior art, providing, a kind of mobile terminal quantitative analysis is dry
The system and method for chemical detection strip.The method of the present invention is simple and convenient to operate, is not necessarily to external equipment, you can quantitative analysis is examined
The concentration of test-strips.
Technical solution：The system of mobile terminal quantitative analysis dry chemical detection strip of the present invention, including detection strip
And mobile terminal, the mobile terminal include application module, the application module includes,
Image acquisition units carry out image taking to the detection strip；
Image processing unit, the image noise reduction deblurring to image acquisition units shooting and extraction color edges line；Noise reduction removes mould
Paste, including each color component is read to all pixels point on image, use weighted mean filter and medium filtering in detection strip
Remove the Gaussian noise and salt-pepper noise in image；Color edges line is extracted, the fuzzy saltus step cell god of adaptive threshold is used
Transition line through network algorithm each color component along the length direction extraction image of detection strip, the transition of color component are linear
At crosspoint, several crosspoints constitute the color edges line in detection strip；
Concentration computing unit establishes concentration curve, and calculates sample concentration value；Concentration computing unit is made with the length for detecting strip
For X-axis, concentration curve is established using sample concentration value as Y-axis；The color edges line that image processing unit is read is in X-coordinate
Weighted average on axis finds Y value corresponding with the X values, Y value is the concentration value of sample as X values according to concentration curve.
Further, the surface of the detection strip is provided with coding information, and the coding information includes detection project name
Claim, detect strip source and measurement range information.
Further, the application module further includes testing result uploading unit, is used for sample concentration value and the volume
Code information is uploaded to cloud database and checks and manage for user.
Further, described image collecting unit includes imaging identification device, for detection strip described in automatic identification at
Seem no clear；If imaging clearly, manually or automatically shot detection strip image；If imaging is unintelligible, institute can not be shot
State detection strip image.
The present invention also provides a kind of methods that mobile terminal quantitative analysis dry chemical detects strip, open taking the photograph for mobile terminal
As head, adjusts camera, aperture and detection strip and is on same straight line, include the following steps,
（1）Start application module, image acquisition units carry out image taking to the detection strip；
（2）The image noise reduction deblurring and extraction color edges line that image processing unit shoots image acquisition units；Noise reduction is gone
It is fuzzy, including each color component is read to all pixels point on image, it is filtered using weighted mean filter and intermediate value in detection strip
Wave removes Gaussian noise and salt-pepper noise in image；Color edges line is extracted, the fuzzy saltus step cell of adaptive threshold is used
The transition line of neural network algorithm each color component along the length direction extraction image of detection strip, the transition line of color component
Crosspoint is formed, several crosspoints constitute the color edges line in detection strip；
（3）Concentration computing unit establishes concentration curve, and calculates sample concentration value；Concentration computing unit is to detect the length of strip
Degree is used as X-axis, and concentration curve is established using sample concentration value as Y-axis；The color edges line that image processing unit is read is in X
Weighted average in reference axis finds Y value corresponding with the X values, Y value is the dense of sample as X values according to concentration curve
Angle value；
（4）Testing result is uploaded to cloud database and checks and manage for user by testing result uploading unit.
Advantageous effect：（1）The present invention analyzes the concentration of detection strip by mobile terminal direct quantitative, is set without external
Standby, method is simple and convenient to operate, and greatly improves convenience.
（2）The detection process of the present invention can carry out the of less demanding of environment light background under common light background
Detection, adaptability are stronger.
（3）The application module of mobile terminal of the present invention is for the range information to change colour in detection strip, and reading is face
The relative changing value of color carries out weighted average processing after image progress subregion is taken catastrophe point, and analyzing processing workload is few, locates
Reason speed is fast, error is small, task is simple, versatile, can be adapted for different change color systems；As versatility platform, can use
In the detection content of disparity items, while the direct quantitative detection of multiple projects is completed on a mobile phone, it is applied widely.
Description of the drawings
Fig. 1 is present invention detection strip color component distribution map.
Fig. 2 is concentration curve of the present invention.
Fig. 3 is prior art color component canonical plotting.
Specific implementation mode
Technical solution of the present invention is described in detail below by attached drawing, but protection scope of the present invention is not limited to
The embodiment.
Embodiment 1：A kind of system of mobile terminal quantitative analysis dry chemical detection strip, including detection strip, movement are eventually
End and cloud database.The mobile terminal includes application module, and application module includes image acquisition units, image procossing list
Member, concentration computing unit and testing result uploading unit.Mobile terminal includes the mobile devices such as mobile phone, tablet computer, using mould
Block realizes that application module is installed and be can be used on mobile terminals by function, user by software programming.
The surface of detection strip is provided with coding information, and coding information is the forms such as bar code and Quick Response Code, coding information
Including detection project title, detection strip source and measurement range information.
Image acquisition units are used for the image information of shot detection strip, before being detected strip image taking, adjust
Camera, aperture and the detection strip of mobile terminal are located along the same line.Image acquisition units include imaging identification device, are used
It is whether clear in the coding information of automatic identification detection strip and colouring information imaging.If imaging clearly is manually or automatically clapped
Take the photograph detection strip image；It, can not shot detection strip image if imaging is unintelligible.
Image processing unit, the image noise reduction deblurring to image acquisition units shooting and extraction color edges line；Noise reduction
Deblurring, including each color component is read to all pixels point on image, use weighted mean filter and intermediate value in detection strip
Gaussian noise in filtering removal image and salt-pepper noise；Color edges line is extracted, it is thin using the fuzzy saltus step of adaptive threshold
The transition line of born of the same parents' neural network algorithm each color component along the length direction extraction image of detection strip, the transition of color component
Line forms crosspoint, and several crosspoints constitute the color edges line in detection strip.Preferably, in order to make the detection strip of extraction
The position of upper color edges line is more accurate, and detection strip is divided into several lateral blocks, is found out according to the method described above each
The position of block color edges line, to the position weighted average value of all colours edge line, to obtain entire detection strip
Color edges line.
Concentration computing unit establishes concentration curve, and calculates sample concentration value；As shown in Fig. 2, concentration computing unit is to examine
The length of test-strips establishes concentration curve as X-axis, using sample concentration value as Y-axis；The face that image processing unit is read
Weighted average of the color edge line in X-coordinate axle finds Y value corresponding with the X values as X values, according to concentration curve, and Y value is
For the concentration value of sample.
Testing result uploading unit will detect the upload of the testing results such as the concentration value of coding information and sample of strip surface
To cloud database resource-sharing.After user is by application module login account, testing result can be uploaded to cloud database,
Conveniently in the future to the analysis of detection data and management.Application module can realize based on Android, IOS, Windows,
The data synchronizing function of the systems such as BlackBerry, Symbian and JAVA.
A kind of method of mobile terminal quantitative analysis dry chemical detection strip, includes the following steps：
（1）Start application module, open the camera of mobile terminal, adjusts camera, aperture and detection strip and be located at always
On line.
（2）Image acquisition units automatically adjust aperture, auto-focusing, and automatic identification detects the coding information and face in strip
Color information.When imaging clearly on screen, the mode manually or automatically taken pictures acquires image information；It is unintelligible when being imaged
When, then it can not shoot.
（3）Image processing unit receive image acquisition units shooting image, the coding information area on reading test strips surface and
Colouring information area.Image processing unit, the image noise reduction deblurring to image acquisition units shooting and extraction color edges line；Drop
It makes an uproar deblurring, including each color component is read to all pixels point on image, such as tri- kinds of color components of R, G and B in RGB systems
Extraction；The Gaussian noise and salt-pepper noise in weighted mean filter and medium filtering removal image are used in detection strip.Extraction
Color edges line extracts figure using the fuzzy saltus step cell neural network algorithm of adaptive threshold along the length direction of detection strip
The transition line of the transition line of each color component as in, color component forms crosspoint, as shown in Figure 1, since detection strip is in length
The mutation for spending color on direction, results in longitudinal transition of the color component in variant positions, the transition line of two kinds of color components
Form crosspoint A；Several crosspoints constitute the color edges line in detection strip.
（4）Concentration computing unit establishes concentration curve, and calculates sample concentration value；Concentration computing unit is to detect strip
Length as X-axis, establish concentration curve using sample concentration value as Y-axis；The color edges that image processing unit is read
Weighted average of the line in X-coordinate axle finds Y value corresponding with the X values as X values, according to concentration curve, and Y value is sample
Concentration value.
（5）Testing result uploading unit will detect in the testing results such as the concentration value of coding information and detection of strip surface
Cloud database is reached to check and manage for user.
As described above, although the present invention has been indicated and described with reference to specific preferred embodiment, must not explain
For the limitation to invention itself.It without prejudice to the spirit and scope of the invention as defined in the appended claims, can be right
Various changes can be made in the form and details for it.
Claims (5)
1. a kind of system of mobile terminal quantitative analysis dry chemical detection strip, including detection strip and mobile terminal, the shifting
Dynamic terminal includes application module, it is characterised in that：The application module includes,
Image acquisition units carry out image taking to the detection strip；
Image processing unit, the image noise reduction deblurring to image acquisition units shooting and extraction color edges line；Noise reduction removes mould
Paste, including each color component is read to all pixels point on image, use weighted mean filter and medium filtering in detection strip
Remove the Gaussian noise and salt-pepper noise in image；Color edges line is extracted, the fuzzy saltus step cell god of adaptive threshold is used
Transition line through network algorithm each color component along the length direction extraction image of detection strip, the transition of color component are linear
At crosspoint, several crosspoints constitute the color edges line in detection strip；
Concentration computing unit establishes concentration curve, and calculates sample concentration value；Concentration computing unit is made with the length for detecting strip
For X-axis, concentration curve is established using sample concentration value as Y-axis；The color edges line that image processing unit is read is in X-coordinate
Weighted average on axis finds Y value corresponding with the X values, Y value is the concentration value of sample as X values according to concentration curve.
2. the system of mobile terminal quantitative analysis dry chemical detection strip according to claim 1, it is characterised in that：It is described
The surface of detection strip is provided with coding information, and the coding information includes detection project title, detection strip source and measurement
Range information.
3. the system of mobile terminal quantitative analysis dry chemical detection strip according to claim 2, it is characterised in that：It is described
Application module further includes testing result uploading unit, for sample concentration value and the coding information to be uploaded to cloud database
It checks and manages for user.
4. the system of mobile terminal quantitative analysis dry chemical detection strip according to claim 1, it is characterised in that：It is described
Whether image acquisition units include imaging identification device, clear for detection strip imaging described in automatic identification；If imaging clearly,
Then manually or automatically shot detection strip image；If imaging is unintelligible, the detection strip image can not be shot.
5. a kind of method of mobile terminal quantitative analysis dry chemical detection strip, opens the camera of mobile terminal, adjusts camera shooting
Head, aperture and detection strip are on same straight line, it is characterised in that：Include the following steps,
（1）Start application module, image acquisition units carry out image taking to the detection strip；
（2）The image noise reduction deblurring and extraction color edges line that image processing unit shoots image acquisition units；Noise reduction is gone
It is fuzzy, including each color component is read to all pixels point on image, it is filtered using weighted mean filter and intermediate value in detection strip
Wave removes Gaussian noise and salt-pepper noise in image；Color edges line is extracted, the fuzzy saltus step cell of adaptive threshold is used
The transition line of neural network algorithm each color component along the length direction extraction image of detection strip, the transition line of color component
Crosspoint is formed, several crosspoints constitute the color edges line in detection strip；
（3）Concentration computing unit establishes concentration curve, and calculates sample concentration value；Concentration computing unit is to detect the length of strip
Degree is used as X-axis, and concentration curve is established using sample concentration value as Y-axis；The color edges line that image processing unit is read is in X
Weighted average in reference axis finds Y value corresponding with the X values, Y value is the dense of sample as X values according to concentration curve
Angle value；
（4）Testing result is uploaded to cloud database and checks and manage for user by testing result uploading unit.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810121209.1A CN108333176A (en) | 2018-02-07 | 2018-02-07 | A kind of system and method for mobile terminal quantitative analysis dry chemical detection strip |
| PCT/CN2018/124212 WO2019153934A1 (en) | 2018-02-07 | 2018-12-27 | System and method for quantitatively analyzing dry chemical test strip by means of mobile terminal |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810121209.1A CN108333176A (en) | 2018-02-07 | 2018-02-07 | A kind of system and method for mobile terminal quantitative analysis dry chemical detection strip |
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| CN108333176A true CN108333176A (en) | 2018-07-27 |
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| CN201810121209.1A Pending CN108333176A (en) | 2018-02-07 | 2018-02-07 | A kind of system and method for mobile terminal quantitative analysis dry chemical detection strip |
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| WO (1) | WO2019153934A1 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107356737A (en) * | 2017-07-03 | 2017-11-17 | 华南理工大学 | A kind of preparation method of Activity determination Quick Response Code |
| WO2019153934A1 (en) * | 2018-02-07 | 2019-08-15 | 曾嵘斌 | System and method for quantitatively analyzing dry chemical test strip by means of mobile terminal |
| CN110473607A (en) * | 2019-06-28 | 2019-11-19 | 马鞍山师范高等专科学校 | A kind of multiple terminals interactive biological medical image analysis system |
| CN110849808A (en) * | 2019-10-24 | 2020-02-28 | 刘钢 | Colorimetric measurement analysis mobile platform equipment |
| CN112014387A (en) * | 2020-08-18 | 2020-12-01 | 苏州纽艾健康科技有限公司 | General dry chemical test paper reading system and method |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USD970033S1 (en) | 2020-10-23 | 2022-11-15 | Becton, Dickinson And Company | Cartridge imaging background device |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2462387Y (en) * | 2001-01-21 | 2001-11-28 | 张同军 | Density gradient medicine sensitive test strip |
| CN104198482A (en) * | 2014-09-05 | 2014-12-10 | 北京智云达科技有限公司 | Test paper reading method and test paper reading device |
| CN104807798A (en) * | 2015-05-18 | 2015-07-29 | 合肥工业大学 | Method and device for detecting up-conversion luminescence by utilizing mobile phone |
| CN105021596A (en) * | 2014-04-18 | 2015-11-04 | 曾嵘斌 | Concentration gradient based dry chemical test strip with multiple layers of films |
| CN107121542A (en) * | 2017-04-28 | 2017-09-01 | 厦门大学 | A kind of immunity-chromatography test strip quantitative detection system and method based on mobile phone |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108333176A (en) * | 2018-02-07 | 2018-07-27 | 曾嵘斌 | A kind of system and method for mobile terminal quantitative analysis dry chemical detection strip |
-
2018
- 2018-02-07 CN CN201810121209.1A patent/CN108333176A/en active Pending
- 2018-12-27 WO PCT/CN2018/124212 patent/WO2019153934A1/en active Application Filing
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2462387Y (en) * | 2001-01-21 | 2001-11-28 | 张同军 | Density gradient medicine sensitive test strip |
| CN105021596A (en) * | 2014-04-18 | 2015-11-04 | 曾嵘斌 | Concentration gradient based dry chemical test strip with multiple layers of films |
| CN105021596B (en) * | 2014-04-18 | 2017-09-29 | 曾嵘斌 | Multilayer film dry chemical detection strip based on concentration gradient |
| CN104198482A (en) * | 2014-09-05 | 2014-12-10 | 北京智云达科技有限公司 | Test paper reading method and test paper reading device |
| CN104807798A (en) * | 2015-05-18 | 2015-07-29 | 合肥工业大学 | Method and device for detecting up-conversion luminescence by utilizing mobile phone |
| CN107121542A (en) * | 2017-04-28 | 2017-09-01 | 厦门大学 | A kind of immunity-chromatography test strip quantitative detection system and method based on mobile phone |
Non-Patent Citations (4)
| Title |
|---|
| （美）斯华龄（HAROLD SZU），张立明编著: "《智能视觉图像处理 多通道图像的无监督学习方法及其他方法》", 31 October 2002, 上海：上海科技教育出版社 * |
| 何东健主编: "《数字图像处理》", 28 February 2015, 西安：西安电子科技大学出版社 * |
| 曾念寅等: "《纳米金免疫层析试条定量检测的研究》", 《生物医学工程研究》 * |
| 郭启勇主编: "《中华临床医学影像学 医学影像信息学与质量控制分册》", 31 January 2016, 北京：北京大学医学出版社 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107356737A (en) * | 2017-07-03 | 2017-11-17 | 华南理工大学 | A kind of preparation method of Activity determination Quick Response Code |
| WO2019153934A1 (en) * | 2018-02-07 | 2019-08-15 | 曾嵘斌 | System and method for quantitatively analyzing dry chemical test strip by means of mobile terminal |
| CN110473607A (en) * | 2019-06-28 | 2019-11-19 | 马鞍山师范高等专科学校 | A kind of multiple terminals interactive biological medical image analysis system |
| CN110849808A (en) * | 2019-10-24 | 2020-02-28 | 刘钢 | Colorimetric measurement analysis mobile platform equipment |
| CN112014387A (en) * | 2020-08-18 | 2020-12-01 | 苏州纽艾健康科技有限公司 | General dry chemical test paper reading system and method |
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