CN110473607A - A kind of multiple terminals interactive biological medical image analysis system - Google Patents
A kind of multiple terminals interactive biological medical image analysis system Download PDFInfo
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- CN110473607A CN110473607A CN201910576310.0A CN201910576310A CN110473607A CN 110473607 A CN110473607 A CN 110473607A CN 201910576310 A CN201910576310 A CN 201910576310A CN 110473607 A CN110473607 A CN 110473607A
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T7/00—Image analysis
- G06T7/0002—Inspection of images, e.g. flaw detection
- G06T7/0012—Biomedical image inspection
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H30/00—ICT specially adapted for the handling or processing of medical images
- G16H30/20—ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/10—Image acquisition modality
- G06T2207/10064—Fluorescence image
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/20—Special algorithmic details
- G06T2207/20081—Training; Learning
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T2207/00—Indexing scheme for image analysis or image enhancement
- G06T2207/30—Subject of image; Context of image processing
- G06T2207/30004—Biomedical image processing
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Abstract
The invention discloses a kind of multiple terminals interactive biological medical image analysis systems, comprising: auxiliary observation device, auxiliary observation device examine test paper for placing；Multiple acquisition terminals, acquisition terminal are used to acquire the image information for examining test paper；Cloud server, cloud server are connect with each acquisition terminal respectively, for calculating and exporting the testing result of image information.Multiple terminals interactive biological medical image analysis system of the invention acquires the image of the inspection test paper on auxiliary observation device by a variety of different types of acquisition terminals, it is transmitted to cloud server, cloud server calculates and exports the testing result of image information, so that user rapidly obtains accurate detection result, without professional detection device and avoid processing calculator periodic replacement, realize efficient, flexible, economic, general analysis Biologic Medical Image.
Description
Technical field
The invention belongs to micro-imaging analysis technical fields, more particularly, to a kind of multiple terminals interactive biological medicine
Image analysis system.
Background technique
Currently, Biologic Medical Image analysis system is mainly include the following types: the local analytics system of fixed algorithm (contains image
Acquisition device), the on-line analysis system (being free of image acquisition device) of fixed algorithm and the local analytics of intelligent algorithm
System (contains image acquisition device).
These three types of Biologic Medical Image analysis systems are all that the Biologic Medical Image for obtaining certain approach carries out algorithm point
Analysis, then obtains corresponding pathological analysis result.Three classes analysis system respectively has feature:
The local analytics system of fixed algorithm generally contains image modalities, preset by image transmission into computer
Software can analyze image according to fixed algorithm.This analysis system is more classical and traditional, the deficiency being primarily present
It is that parser needs software developer constantly to upgrade, and with the continuous increase of calculation amount, hardware is also required to constantly update
It regenerates, input cost is higher.
The on-line analysis system of fixed algorithm is typically free of image acquisition device, needs user by collected image data
It is transferred to corresponding website.The analysis report of the fed back to user of existing this analysis system also relies on fixed algorithm mostly
With the experience of skilled addressee, analytical cycle is long, and the real-time that user obtains analysis result is poor.
The local analytics system of intelligent algorithm uses intelligent algorithm, can be during user's use constantly
Optimize image analysing computer algorithm, realizes the continuous evolution upgrading of analysis software, be adapted to the same problems to become increasingly complex.However
The analysis system is very high to the allocation of computer requirement of each user, is substantially the artificial intelligence calculating for meeting macrooperation amount
Machine, cost are that ordinary user can not undertake, this is reduced to the popularization of the artificial intelligent biological medical image analysis system
Property.
There is also general character disadvantages for above-mentioned three classes analysis system: first, image capture device customizations are stronger, for analysis
Sample is relatively fixed, is unfavorable for its unitized realization and popularization；Second, with the increase of software operand, image procossing meter
Calculation machine maximum probability needs integral replacing, and maintenance cost is high.Therefore, it needs to develop efficient, flexible, economic, general biomedical shadow
As analysis system.
Summary of the invention
The purpose of the present invention is to propose to a kind of efficient, flexible, economic, general Biologic Medical Image analysis systems.
To achieve the goals above, the present invention provides a kind of multiple terminals interactive biological medical image analysis system, packets
Include: auxiliary observation device, the auxiliary observation device examine test paper for placing；Multiple acquisition terminals, the acquisition terminal are used
In the image information for acquiring the inspection test paper；Cloud server, the cloud server are connect with each acquisition terminal respectively,
For calculating and exporting the testing result of described image information.
Preferably, the acquisition terminal acquires the image information for examining test paper, and described image information is transmitted to
The cloud server.
Preferably, the cloud server calculates the acquisition figure by acquiring image described in detective operators model analysis
The testing result is simultaneously transmitted to the acquisition terminal by the testing result of picture.
Preferably, the cloud server is based on training sample database and generates the detective operators mould by algorithm training
Type.
Preferably, the cloud server extracts the training sample of the training sample database；Analyze the trained sample
This image information；Extract the characteristic information of the training sample；Based on the characteristic information, the detective operators mould is generated
Type.
Preferably, the cloud server chooses image information as new training sample according to testing result and is added to institute
State training sample database；New detective operators model is generated based on the training sample database after addition.
Preferably, the testing result of the cloud server parallel computation multiple images information.
Preferably, the cloud server uses the calculating of pci bus, PXI bus, PCIe bus or LXI bus architecture
Machine.
Preferably, the cloud server uses the structure system of web application.
Preferably, the acquisition terminal is the equipment for having data transmission capabilities and image collection function.
The beneficial effects of the present invention are: multiple terminals interactive biological medical image analysis system of the invention passes through a variety of
The image of inspection test paper on different types of acquisition terminal acquisition auxiliary observation device is transmitted to cloud server, cloud clothes
Business device calculates and exports the testing result of image information, so that user rapidly obtains accurate detection as a result, without special
Industry detection device and the periodic replacement for avoiding processing calculator realize efficient, flexible, economic, general analysis biology
Medical image.
System of the invention has other characteristics and advantages, these characteristics and advantages from the attached drawing being incorporated herein and with
Will be apparent in specific embodiment afterwards, or by the attached drawing and subsequent specific embodiment being incorporated herein into
Row statement, these the drawings and specific embodiments in detail are used together to explain specific principle of the invention.
Detailed description of the invention
Exemplary embodiment of the invention is described in more detail in conjunction with the accompanying drawings, it is of the invention above-mentioned and its
Its purpose, feature and advantage will be apparent.Wherein, in exemplary embodiment of the invention, identical appended drawing reference
Typically represent same parts.
Fig. 1 shows the company of interactive biological medical image analysis system in multiple terminals according to an embodiment of the invention
Binding composition.
As Fig. 2-Fig. 5 respectively illustrates interactive biological medical image in multiple terminals according to an embodiment of the invention point
The concentration 0 of the acquisition terminal acquisition of analysis system, concentration 1, concentration 2, the bar shaped test paper reaction of the FTA card substrate of 3 grade of concentration are glimmering
Light image.
Fig. 6 shows the base of interactive biological medical image analysis system in multiple terminals according to an embodiment of the invention
Change line chart with concentration in the fluorescence signal intensity of the bar shaped test paper of FTA card substrate, abscissa is concentration, and ordinate is signal
Intensity.
As Fig. 7-Figure 11 respectively illustrates interactive biological medical image in multiple terminals according to an embodiment of the invention
The bar shaped test paper of concentration 0, concentration 1, concentration 2, concentration 3, the NC film substrate of 4 grade of concentration that the acquisition terminal of analysis system acquires
React fluorescent image.
Figure 12 shows interactive biological medical image analysis system in multiple terminals according to an embodiment of the invention
The fluorescence signal intensity of bar shaped test paper based on NC film substrate changes line chart with concentration, and abscissa is concentration, and ordinate is letter
Number intensity.
Description of symbols:
1, auxiliary observation device；2, acquisition terminal；3, cloud server；10, test paper is examined.
Specific embodiment
The preferred embodiment that the present invention will be described in more detail below with reference to accompanying drawings.Although being shown in attached drawing of the invention
Preferred embodiment, however, it is to be appreciated that may be realized in various forms the present invention without should be by embodiments set forth herein institute
Limitation.On the contrary, thesing embodiments are provided so that the present invention is more thorough and complete, and can be by the scope of the present invention
Completely it is communicated to those skilled in the art.
A kind of multiple terminals interactive biological medical image analysis system according to the present invention, comprising: auxiliary observation device, it is auxiliary
Observation device is helped to examine test paper for placing；Multiple acquisition terminals, acquisition terminal are used to acquire the image information for examining test paper；Cloud
Server is held, cloud server is connect with each acquisition terminal respectively, for calculating and exporting the testing result of image information.
Specifically, the inspection test paper with test samples is placed on auxiliary observation device by user, pass through acquisition terminal
The image information of test paper is examined in acquisition, and image information includes image, video recording, and the image information of acquisition is sent to cloud by acquisition terminal
Server is held, cloud server carries out analytical calculation to received image information and obtains inspection result, and inspection result is exported
To the acquisition terminal of user, user is facilitated to check, this local acquisition terminal acquires image, and cloud server processing image is
System framework quite economizes on resources, while the demand of terminal handler is reduced using cloud server, and terminal is greatly saved
Hardware cost.
It is whole by a variety of different types of acquisitions according to illustrative multiple terminals interactive biological medical image analysis system
The image of inspection test paper on end acquisition auxiliary observation device, is transmitted to cloud server, cloud server calculates and exports figure
As the testing result of information, so that user rapidly obtains accurate detection as a result, without professional detection device and avoiding
The periodic replacement of processing calculator, realizes efficient, flexible, economic, general analysis Biologic Medical Image.
Preferably, the image information of test paper is examined in acquisition terminal acquisition, and image information is transmitted to cloud clothes
Business device.
Preferably, cloud server acquires image by detective operators model analysis, calculates the inspection of acquisition image
It surveys result and will test result and be transmitted to acquisition terminal.
Specifically, cloud server is analyzed and calculated to received image information by detective operators model, obtain
It acquires the testing result of image and will test result and be transmitted to acquisition terminal, easily check testing result in real time convenient for user.
Preferably, cloud server is based on training sample database and generates detective operators mould by algorithm training
Type.
Preferably, cloud server extracts the training sample of training sample database；The figure of analyzing and training sample
As information；Extract the characteristic information of training sample；Based on characteristic information, detective operators model is generated.
Specifically, cloud server is equipped with training sample database, by extracting the training sample in training sample database
This, the image information of analyzing and training sample extracts the characteristic point in image information, and characteristic point includes color, structure, image, shape
State, area etc., according to the type of characteristic point every kind of characteristic point is set shared by weight, characteristic point is characteristic information, based on spy
Reference breath and shared weight generate detective operators model.
Preferably, cloud server is chosen image information according to testing result and is added to as new training sample
Training sample database；New detective operators model is generated based on the training sample database after addition.
Specifically, the clinical image information of cloud server selection known assay result and the clinical test image letter of user
The training sample as training sample database is ceased, initial detecting Operator Model is generated based on training sample database.It is analyzing
Representative image information and the acquisition of variety classes acquisition terminal are selected while calculating acquisition terminal image information
Image information is added to training sample database, and new detective operators model is generated based on the training sample database after addition,
Analytical calculation is carried out using new detective operators model, continues to optimize the image processing algorithms of cloud server, is improved at influence
The analysis precision of reason.
Preferably, the testing result of cloud server parallel computation multiple images information.
Preferably, cloud server uses the meter of pci bus, PXI bus, PCIe bus or LXI bus architecture
Calculation machine.
Preferably, cloud server uses the structure system of web application.
Specifically, computer of the cloud server using pci bus, PXI bus, PCIe bus or LXI bus architecture, just
In arithmetic elements such as the GPU for extending corresponding bus interface, using the structure system of web application, cloud server is to reception
The image information arrived carries out parallel computation, while receiving multiple acquisition terminal image informations, and parallel computation obtains corresponding detection
As a result, and corresponding testing result is sent to corresponding acquisition terminal, provide analysis data more quickly for acquisition terminal.
Preferably, acquisition terminal is the equipment for having data transmission capabilities and image collection function.
Specifically, acquisition terminal is the various equipment for having data transmission capabilities and image collection function, such as hand is mechanical, electrical
Brain, tablet computer etc..
Embodiment one
Fig. 1 shows the company of interactive biological medical image analysis system in multiple terminals according to an embodiment of the invention
Binding composition.
As shown in Figure 1, the multiple terminals interactive biological medical image analysis system, comprising: auxiliary observation device 1, auxiliary
It observes device 1 and examines test paper 10 for placing, for example, test paper 10 is examined to select RT-PCR test paper；Multiple acquisition terminals 2, acquisition
Terminal 2 is used to acquire the image information for examining test paper 10；Cloud server 3, cloud server 3 respectively with each acquisition terminal 2
Connection, for calculating and exporting the testing result of image information.
Wherein, the image information of test paper 10 is examined in the acquisition of acquisition terminal 2, and image information is transmitted to cloud server 3.
Wherein, cloud server 3 acquires image by detective operators model analysis, calculates the testing result of acquisition image simultaneously
It will test result and be transmitted to acquisition terminal 2.
Wherein, cloud server 3 is based on training sample database and generates detective operators model by algorithm training.
Wherein, cloud server 3 extracts the training sample of training sample database；The image information of analyzing and training sample；
Extract the characteristic information of training sample；Based on characteristic information, detective operators model is generated.
Wherein, cloud server 3 chooses image information as new training sample according to testing result and is added to trained sample
Database；New detective operators model is generated based on the training sample database after addition.
Wherein, the testing result of 3 parallel computation multiple images information of cloud server.
Wherein, computer of the cloud server 3 using pci bus, PXI bus, PCIe bus or LXI bus architecture, example
If cloud server 3 is configured using PXI-3800 cabinet with PXI-3980 mainboard, tried by detective operators model analysis RT-PCR
The PCR conversion zone area and intensity of paper.
Wherein, cloud server 3 uses the structure system of web application.
Wherein, acquisition terminal 2 is the equipment for having data transmission capabilities and image collection function, such as acquisition terminal 2 selects
With red rice NOTE mobile phone.
Experiment 1
As Fig. 2-Fig. 5 respectively illustrates interactive biological medical image in multiple terminals according to an embodiment of the invention point
The concentration 0 of the acquisition terminal acquisition of analysis system, concentration 1, concentration 2, the bar shaped test paper reaction of the FTA card substrate of 3 grade of concentration are glimmering
Light image.Fig. 6 shows the base of interactive biological medical image analysis system in multiple terminals according to an embodiment of the invention
Change line chart with concentration in the fluorescence signal intensity of the bar shaped test paper of FTA card substrate, abscissa is concentration, and ordinate is signal
Intensity.
Test paper: the bar shaped test paper of FTA card substrate
Experiment purpose: LAMP experiment in original position is carried out on FTA card, exposes the 1ms time, is acquired by acquisition terminal from concentration
The test paper of 0 to 3 grade of concentration reacts fluorescent image, and fluoroscopy image sequence is as Figure 2-Figure 5, and cloud server carries out it glimmering
Luminous intensity assessment.
Image processing process: image is first passed to cloud server by acquisition terminal, and cloud server first carries out image high
This noise reduction process eliminates the noise spot in fluorescent image extent of fluorescence, and it is glimmering then to carry out image histogram analysis image to image
Luminous intensity A, then the edge extracting of Sobel operator is carried out to image, the fluorescence model for obtaining bianry image is handled by Image erosion
S is enclosed, the weighting fluorescence intensity Sw of each sub-picture is obtained by the fluorescence intensity comprehensive calculation method of detective operators model.Detection
Operator Model stores the additive process moment matrix of training operator, is formed for subsequent genetic algorithm standby by iteration and from correcting
Case.The disposable cloud processing time is 0.1ms.
Result visualization is shown: processing result image is depicted as line chart by cloud server, is transmitted to acquisition terminal, such as
Fig. 6 show fluorescence signal intensity and changes line chart with concentration, and abscissa is concentration, and ordinate is signal strength.
Experiment 2
As Fig. 7-Figure 11 respectively illustrates interactive biological medical image in multiple terminals according to an embodiment of the invention
The bar shaped test paper of concentration 0, concentration 1, concentration 2, concentration 3, the NC film substrate of 4 grade of concentration that the acquisition terminal of analysis system acquires
React fluorescent image.Figure 12 shows multiple terminals interactive biological medical image analysis system according to an embodiment of the invention
The fluorescence signal intensity of the bar shaped test paper based on NC film substrate of system changes line chart with concentration, and abscissa is concentration, ordinate
For signal strength.
Test paper: the bar shaped test paper of NC film substrate
Experiment purpose: LAMP experiment in original position is carried out on NC film substrate test paper, the 75ms time is exposed, is adopted by acquisition terminal
Collection reacts fluorescent image from the test paper of 4 grade of concentration 0- concentration, and fluoroscopy image sequence is as shown in Fig. 7-Figure 11, cloud server pair
It carries out fluorescence intensity assessment.
Image processing process: acquisition terminal is by the image transmitting of acquisition to cloud server, and cloud server is first to image
Gauss noise reduction process is carried out, the noise spot in fluorescent image extent of fluorescence is eliminated, image histogram analysis then is carried out to image
Image fluorescence intensity A, then the edge extracting of Sobel operator is carried out to image, it is handled by Image erosion and obtains bianry image
Extent of fluorescence S obtains the weighting fluorescence intensity of each sub-picture by the fluorescence intensity comprehensive calculation method of detective operators model
Sw.To found after morphological analysis image sequence there are isolated island features at edge, therefore, add main feature filter algorithm,
The isolated island feature of image peripheral is removed.Revised Sw is calculated again.Detective operators model by iteration and from correcting, instruct by storage
Practice the additive process moment matrix of operator, puts on record for the formation of subsequent genetic algorithm.The disposable cloud processing time is 0.7ms.
Result visualization is shown: processing result image is depicted as line chart by cloud server, is transmitted to acquisition terminal, such as
Figure 12 show fluorescence signal intensity and changes line chart with concentration, and abscissa is concentration, and ordinate is signal strength.
The embodiment of the present invention is described above, above description is exemplary, and non-exclusive, and also not
It is limited to disclosed embodiment.Without departing from the scope and spirit of embodiment described, for the art
Those of ordinary skill for many modifications and changes are obvious.
Claims (10)
1. a kind of multiple terminals interactive biological medical image analysis system characterized by comprising
Auxiliary observation device, the auxiliary observation device examine test paper for placing；
Multiple acquisition terminals, the acquisition terminal are used to acquire the image information for examining test paper；
Cloud server, the cloud server are connect with each acquisition terminal respectively, for calculating and exporting described image letter
The testing result of breath.
2. interactive biological medical image analysis system in multiple terminals according to claim 1, which is characterized in that the acquisition
Terminal acquires the image information for examining test paper, and described image information is transmitted to the cloud server.
3. interactive biological medical image analysis system in multiple terminals according to claim 1, which is characterized in that the cloud
Server calculates the testing result of the acquisition image and by the detection by acquiring image described in detective operators model analysis
As a result it is transmitted to the acquisition terminal.
4. interactive biological medical image analysis system in multiple terminals according to claim 3, which is characterized in that the cloud
Server is based on training sample database and generates the detective operators model by algorithm training.
5. interactive biological medical image analysis system in multiple terminals according to claim 4, which is characterized in that the cloud
Server extracts the training sample of the training sample database；Analyze the image information of the training sample；Extract the instruction
Practice the characteristic information of sample；Based on the characteristic information, the detective operators model is generated.
6. interactive biological medical image analysis system in multiple terminals according to claim 5, which is characterized in that the cloud
Server chooses image information as new training sample according to testing result and is added to the training sample database；Based on adding
Training sample database after adding generates new detective operators model.
7. interactive biological medical image analysis system in multiple terminals according to claim 1, which is characterized in that the cloud
The testing result of server parallel computation multiple images information.
8. interactive biological medical image analysis system in multiple terminals according to claim 1, which is characterized in that the cloud
Server uses the computer of pci bus, PXI bus, PCIe bus or LXI bus architecture.
9. interactive biological medical image analysis system in multiple terminals according to claim 1, which is characterized in that the cloud
Server uses the structure system of web application.
10. interactive biological medical image analysis system in multiple terminals according to claim 1, which is characterized in that described to adopt
Collecting terminal is the equipment for having data transmission capabilities and image collection function.
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