CN104964973A - Test paper reading and analyzing method and system based on mobile terminal camera - Google Patents

Test paper reading and analyzing method and system based on mobile terminal camera Download PDF

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CN104964973A
CN104964973A CN 201510397181 CN201510397181A CN104964973A CN 104964973 A CN104964973 A CN 104964973A CN 201510397181 CN201510397181 CN 201510397181 CN 201510397181 A CN201510397181 A CN 201510397181A CN 104964973 A CN104964973 A CN 104964973A
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color
sample
concentration
test
region
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CN 201510397181
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邓双胜
张磊
林洁
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邓双胜
张磊
林洁
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Abstract

The invention discloses a test paper reading and analyzing method and system based on a mobile terminal camera, which is used for calculating a concentration value of a to-be-detected substance in a detection sample and analyzing a test result. The method comprises the following steps: collecting, by the mobile terminal camera, a test paper image, analyzing and identifying the edge of a color developing area, and intercepting a required color development area; calculating a color value or a gray value of a test area (T line) and a control area (C line) in the color development area picture, and calculating the concentration ratio of the sample by utilizing the ratio of the color value or the gray value of the test area (T line) and the control area (C line); calibrating the sample concentration ratio in batches, substituting the sample concentration ratio into a standard curve of the test paper of the batch to perform the fitting operation, and calculating the real concentration value of the to-be-detected substance in the sample; looking for a matched detection result according to the real concentration value, and transmitting the detection result to the mobile terminal.

Description

一种基于移动终端摄像头的试纸读取与分析方法与系统 Dipstick reading and analysis system and method of a mobile terminal based on the camera

技术领域 FIELD

[0001] 本发明属于试纸读取与分析领域,特别涉及一种基于移动终端摄像头和云端服务器的试纸读取与分析方法与系统。 [0001] The present invention belongs to the reading and analysis of the test paper, and more particularly relates to a mobile terminal strips based camera and a cloud server reads and analysis system.

背景技术 Background technique

[0002] 试纸在诸多领域的样本检测中已经得到了广泛的应用,例如临床医疗中常用的尿常规检测、优生优育、不孕不育检测,环境检测中的甲醛、苯的含量检测,以及食品安全中的瘦肉精、三聚氰胺、地沟油或者农药残留检测等,都需要使用相应的专用试纸进行检测。 [0002] In the paper samples tested in many fields has been widely used, for example, commonly used in clinical urine detection, prenatal and postnatal care, infertility testing, environmental testing formaldehyde, benzene content testing, and food security clenbuterol, melamine, waste oil or pesticide residue detection, the corresponding need to use special paper is detected.

[0003] 一些简单的试纸检验可以通过肉眼观察试纸来实现,例如早早孕试纸,但是这种通过目测试纸的方式只能进行定性的检测,而且如果出现被检测对象含量较低,显色较浅的时候,容易出现误读,另外肉眼观察还受到心情、光线等许多人为或环境因素的干扰,从而影响其准确性。 [0003] Some simple dipstick test can be accomplished by visually paper, for example, early pregnancy test paper, but this can only be performed by visual observation of the test strip of qualitative detection and the detection target if the content is low, there was a color when shallow, prone to misread, additionally also visually observed by many mood disturbance, light and other artificial or environmental factors, which can affect their accuracy. 特别是某些对特定颜色不敏感的人群甚至无法使用该类试纸进行检测。 In particular, some not sensitive to a specific color groups can not even detect the use of such paper.

[0004] 需要进行定量检测的试纸通常是在专业机构中通过特有的设备来完成,还有一些检测需要综合多次检验的结果,依赖专业人员的经验判断才能完成。 [0004] the need for quantitative detection of paper is usually done in a professional organization through the unique equipment, there are some tests require the combined result of a number of tests, the judge can rely on the experience of professionals to complete. 例如宫外孕的早发现对于保护女性生育功能、防止习惯性流产等都有很大的帮助,但宫外孕的预防性检验需要多次测量HCG浓度,如果每48小时HCG浓度增加一倍以上,推断为正常宫内妊娠,若明显低于一倍浓度则宫外孕或发育不良的可能性增大,这样孕妇需多次到医院进行HCG浓度的检测,带来诸多劳累与接触医院交叉感染的风险。 For example, early detection of ectopic pregnancy protect women reproductive function, they are of great help to prevent habitual abortion, but preventive inspection required ectopic pregnancy HCG concentration measured repeatedly, every 48 hours if HCG concentration more than double the normal inference intrauterine pregnancy, the possibility of doubling the concentration is significantly lower than if the ectopic pregnancy or dysplasia increases, so pregnant women need many times to the hospital for HCG detect the concentration of risk in contact with a lot of exertion hospital cross-infection. 但目前已有的检测试纸还无法做到在家庭进行检测,就是受限于家庭定量检测技术的限制。 However, currently available test strips can not be detected in the family to do, it is home to such limitations as quantitative detection technology.

[0005] 即使是专业机构里的检测试纸,对于不同批次的试纸,如果没有配套好的批次校准卡,其检验结果就会有批间差异,也会影响到检测结果的准确性。 [0005] Even the professional bodies in the test strip, for different batches of test strips, if there is no good batch calibration card support, the test result will be a difference between batches, will also affect the accuracy of the test results. 而且免疫检测产品的检测效能在出厂后也会随着时间的延长而产生一定的衰减,传统的检测产品即使在出厂时配有附带校准曲线的校准卡,但无法做到对校准曲线进行随时间变化的实时更新。 And detection performance immunoassay products will over time produce a certain attenuation in the factory, the traditional testing products even with a calibration card that came with the calibration curve at the factory, but can not do the calibration curve over time changes in real-time updates.

发明内容 SUMMARY

[0006]( 一)要解决的技术问题 [0006] (a) To solve technical problems

[0007] 本发明要解决的技术问题是:现有的试纸检测方法中,人工判断的准确性、稳定性差,无法进行定量判定,而机器判定需要专业设备,还有可能需要依赖专业人员的经验判断,必须在专业场所完成检测。 [0007] The present invention is to solve the technical problem: the conventional test paper method, human judgment accuracy, poor stability and can not be quantitatively determined, and the machine determines experience requires specialized equipment, there may need to rely on professionals judgment must be done to detect in professional venues.

[0008] 本发明要解决的另一个问题是,不同批次的试纸之间存在批间差,影响了测量的准确性。 [0008] Another problem to be solved by the present invention is that there is a difference between the batches between different batches of test strips, affecting the measurement accuracy. 传统的检测产品随着时间变化效能也会发生衰减从而影响测量准确性的问题。 Traditional performance testing products can also occur over time in order to attenuate the impact of measurement accuracy.

[0009] 本发明的目的是提供一种基于移动终端摄像头和云端服务器的试纸读取与分析方法与系统,使得用户可以利用现有的移动终端和云端服务器完成试纸的定性和定量检测,在家中或户外即可完成一些原本只有在医院或专业场所里才能完成的检测项目,从而实现远程移动医疗、移动监测的功能。 [0009] The object of the present invention is to provide a dipstick reading and analysis methods and systems based on the mobile terminal camera and a cloud server, so that the user can use the existing mobile terminals and a cloud server to complete qualitative and quantitative detection of the paper at home or outdoors to complete some of the original only in a hospital or specialized sites in order to complete the test items to perform the functions of remote mobile medical, mobile monitoring.

[0010] 本发明的另一个目的是提供一种基于移动终端摄像头和云端服务器的试纸读取与分析方法与系统,消除试纸不同批次的批间差,并提高试纸检测的精确性。 [0010] Another object of the present invention is to provide a method and system of reading and analyzing the test strip based on the mobile terminal camera and a cloud server, to eliminate inter-assay test strip batches of difference, and to improve the accuracy of the test paper.

[0011] (二)技术方案 [0011] (ii) Technical Solution

[0012] 本发明提供一种基于移动终端摄像头和云端服务器的试纸读取与分析方法,用于计算试纸中样本的浓度值并分析测试结果,包括以下步骤:移动终端摄像头采集试纸图像,分析识别显色区的边缘,截取符合要求的显色区域,发送给云端服务器;计算显色区图片中的测试区(T线)和控制区(C线)的颜色值或灰度值,利用两者颜色值或灰度值的比值运算得出样本浓度比;对样本浓度比进行批次校准,将样本浓度比值带入该试纸批次的标准曲线进行拟合运算,计算出该样本中待检物的真实浓度值;根据样本中待检物的真实浓度值查找匹配的检测结果,并将检测结果发送给移动终端。 [0012] The present invention provides a dipstick reading and analysis method of a mobile terminal camera and a cloud server based, for calculating the concentration value of the sample strip and analyze the test results, comprising the steps of: the mobile terminal strip camera capture an image, analysis to identify the edge of the color area, the interception of the line with the requirements of the coloring region, transmits to the server cloud; color or gray value test zone (T) for calculating the color image region and the control region (C line), using both calculating a ratio of the pixel value or gray value concentration ratio obtained sample; sample batch calibration concentration ratio, the ratio of the concentration of the sample into the test strip batch standard curve fitting, and calculates the analyte in the sample the true concentration value; the real analyte concentration in the sample to find the value of the detection result of the matching, the detection result to the mobile terminal.

[0013] 优选的,移动终端摄像头采集试纸图像之前,摄像头首先采集试纸的识别码,将识别码发送给云端服务器,云端服务器从数据库中调用试纸检测项目、批次等信息暂存并返回给移动端。 Before [0013] Preferably, the mobile terminal camera capture strip images, the camera is acquired first identification code strip, and transmits the identification code to the cloud server cloud server calls the test paper items from the database and batch information temporarily stored and returned to the mobile end.

[0014] 可选的,移动终端摄像头采集试纸图像之前,提示用户在移动终端手工选择输入试纸的类别、批次信息,发送给云端服务器。 [0014] Alternatively, before the mobile terminal strip camera capture an image, the user is prompted to select the input category paper by hand in a mobile terminal, batch information, the server transmits to the cloud.

[0015] 优选的,移动终端摄像头采集整个试纸条的图像;颜色和边缘分析识别,通过预先设定试纸的卡壳与显色区域的色差,找到预先设定的边框,选定该区域;在该区域中找出符合预先设定比例要求的区域作为显色区域,并截取出来。 [0015] Preferably, the mobile terminal camera capture images of the entire test strip; and the color analysis identified the edges, by setting in advance stuck to paper color of the coloring region to find predetermined frame, the selected region; the identify the region in line with the preset area ratio requirement as a color area, and taken out.

[0016]另一种优选的方式中,移动终端摄像头采集整个试纸条的图像;筛选定位点的位置,通过定位点定位显色区域的位置和水平、垂直方向的位置;在该区域中找出符合预先设定比例要求的区域作为显色区域,并截取出来。 [0016] In another preferred embodiment, the mobile terminal camera capture the entire image of the test strip; screening setpoint position, and substantially horizontal position, vertical color area is positioned by the positioning point; in this area to find meet the requirements of the preset area ratio as a color area, and taken out.

[0017] 可选的,对于第三方没有预设边框的普通试纸,在显示屏上有符合试纸大小的取景框,提示用户用取景框套住整个试纸或者显色区域,并点击拍照按钮。 [0017] Alternatively, there is no default for third-party common border strip, there viewfinder meet the paper size on the screen, the user is prompted to trap the entire area with paper or color viewfinder and click the camera button.

[0018] 优选的,移动终端对截取的显色区图片进行标准化处理,将图片整理成统一的像素大小,或者将拍照时空间上或平面上偏移的图片旋转回来。 [0018] Preferably, the mobile terminal of the taken color image area is normalized, the image pixel size organized into a unified, or when taking offset in space or plane image rotation back.

[0019] 优选的,在云端服务器中,设参考区(C线)的颜色值或灰度值为β,测试区(Τ线)的颜色值或灰度值为α,通过α与β的相关比值运算得到样本浓度比值γ。 [0019] Preferably, in the cloud server, set the reference region (C line) color value or gray value beta], test zone (Τ line) the color or gray value of [alpha], [alpha] associated with beta] by the calculating the ratio of concentration of the sample to obtain a ratio γ.

[0020] 对于非免疫层析试纸,通过其标准颜色空白垫或者采取边缘、卡壳、外包装的图像,计算颜色值或灰度值,作为参考区颜色值或灰度值β。 [0020] For non immunochromatographic test strip through which the color standard blank or take pad edge, stuck, overpack image, calculates the color or gray value, color or gray value as the reference region β.

[0021] 云端服务器进行批次校准的步骤包括:对应每批生产的试纸产品,使用标准浓度物质对该批次产品进行定标,通过测试区(Τ线)和控制区(C线)两者颜色值或灰度值的比值运算得出样本浓度比;根据样本浓度比值与标准物质真实浓度值的对应关系,产生该批次试纸的标准曲线,并将该标准曲线保存在云端服务器的数据库中;云端服务器根据库存留样的产品随时间变化的改变,更新标准曲线;根据移动终端传输的显色图像,计算出来的样本浓度比(C、T比值),与该批次的标准曲线进行拟合运算,得出本次检验的真实浓度值。 Step [0021] Batch calibration cloud server comprising: corresponding to each production lot of paper products, the concentration of the substance using the standard batch is scaled by a test zone (Τ line) and the control zone (C line) both calculating a ratio of the color or gray value of concentration ratio obtained sample; sample concentration according to the correspondence ratio of standard substance concentration value true, generating a standard curve of the batch of test strips, and the calibration curve stored in the database server in the cloud ; cloud server according to the inventory of the product leaving the sample changes over time, updates the standard curve; mobile terminal in accordance with the color image transfer, the calculated ratio of the concentration of the sample (C, T ratio), the standard curve by fitting the batch co-operation, the true concentration values ​​obtained in this test.

[0022] 在另一个优选的实施方式中,云端服务器还需要判断该检测项目是否需要进行再次检测;如果无需再次检测,则将计算出的样本中待检物的真实浓度值与数据库中的数值范围进行比较,找出该浓度值对应的诊断结果以及相应的医疗建议;保存样本数值以及相应的检测结果,向移动终端发送检测结果、对应的诊断结论以及建议;如果需要进行多次检测,则保存本次样本真实浓度值,向移动终端发送检测样本结果以及下次检测时间;定时器设定下一次检测的时间,并在定时器到达时向移动终端发送提示消息,并接收下一次检测的试纸图片。 [0022] In another preferred embodiment, the first server determines whether the required test items need to be detected again; if necessary to detect again, the true value of the analyte concentration in the database is calculated for the sample to be range compared to find out the result of the diagnosis and the corresponding concentration value corresponding to medical advice; stored sample values ​​and the corresponding detection result, transmits a detection result to the mobile terminal, the corresponding diagnostic conclusions and recommendations; detected several times if necessary, the save this sample the true concentration value, and transmits the detection result of the next sample detection time to the mobile terminal; set timer time detection time, and sends an alert message to the mobile terminal when the timer expires, and the detected reception time dipstick picture.

[0023] 本发明还提供一种基于移动终端摄像头和云端服务器的试纸读取与分析系统,用于计算试纸中样本的浓度值并分析测试结果,包括:移动终端,用于采集试纸图像,分析识别显色区的边缘,截取符合要求的显色区域,发送给云端服务器;云端服务器,用于接收和分析显色区图片,计算显色区图片中的测试区(T线)和控制区(C线)的颜色值或灰度值,利用两者颜色值或灰度值的比值运算得出样本浓度比;对样本浓度比进行批次校准,将样本浓度比值带入该试纸批次的标准曲线进行拟合运算,计算出该样本中待检物的真实浓度值;根据样本中待检物的真实浓度值查找匹配的检测结果,并将检测结果发送给移动终端。 [0023] The present invention further provides a test strip analysis system reads the camera and the mobile terminal based on a cloud server, used to calculate the concentration of the sample strips and analysis of test results, comprising: a mobile terminal for image capture strip, analysis identifying significant color region of edge, taken in line with the requirements of the coloring region, is sent to the cloud server; cloud server for receiving and analyzing the color image area, calculating the color image region in the test zone (T line) and the control zone ( C-line) the color or gray value by calculating the ratio of both the color or gray value of concentration ratio obtained sample; sample batch calibration concentration ratio, the ratio of the concentration of the sample into the standard paper batch curve fitting calculation to calculate the true concentration of the analyte in the sample; find the matching value according to the real analyte concentration of the sample detection result of the detection result to the mobile terminal.

[0024] 用于测试的试纸包括免疫层析试纸或化学显色试纸,所述试纸包括识别码,所示识别码包括二维码、条形码或其他用于识别的编码方式,用于区分试纸的类型和批次信息,位于试纸条及外壳上的任意位置。 [0024] The test strip for immunochromatographic test strip comprising a chemical or a color strip, said strip comprising an identification code, the identification code comprises a two-dimensional code as shown, for identification bar codes or other coding method, for distinguishing dipstick type and batch information, and positioned anywhere on the test strip housing.

[0025] 优选的,移动终端采集试纸图像之前,首先采集试纸的识别码,将识别码发送给云端服务器,云端服务器从数据库中调用试纸检测项目、批次等信息暂存并返回给移动端。 Before [0025] Preferably, the mobile terminal strip image acquisition, the identification code is acquired first strip, and transmits the identification code to the server cloud, the cloud server calls the test paper items from the database, information such as batch staging and returned to the mobile terminal.

[0026] 可选的,移动终端采集试纸图像之前,提示用户在移动终端手工选择输入试纸的类别、批次信息,发送给云端服务器。 [0026] Alternatively, the mobile terminal prior to image capture strip, the user is prompted to select the input paper type, batch information, is sent to the mobile terminal in the cloud server manually.

[0027] 优选的,移动终端还包括:摄像头,用于采集整个试纸条的图像;处理单元,用于颜色和边缘分析识别,通过预先设定试纸的卡壳与显色区域的色差,找到预先设定的边框,选定该区域;在该区域中找出符合预先设定比例要求的区域作为显色区域,并截取出来;发送接收单元,用于将截取的显色区域图像发送给云端服务器。 [0027] Preferably, the mobile terminal further comprising: a camera for acquiring images of the entire test strip; a processing unit for color identification and analysis edge, with the card housing through a predetermined region of the color difference color test paper, previously found setting the borders, the selected region; identify areas meet preset ratio required as a color area, and taken out in the region; transmitting and receiving unit, for displaying a color image area, taken to a cloud server .

[0028] 优选的,移动终端还包括:摄像头,用于采集整个试纸条的图像;处理单元,用于筛选定位点的位置,通过定位点定位显色区域的位置和水平、垂直方向的位置;在该区域中找出符合预先设定比例要求的区域作为显色区域,并截取出来;发送接收单元,用于将截取的显色区域图像发送给云端服务器。 [0028] Preferably, the mobile terminal further comprising: a camera for acquiring images of the entire test strip; a processing unit for filtering the position of the anchor point, and substantially horizontal position, vertical color areas by the positioning point positioning ; find out the area in line with the requirements of the preset area ratio as a color area, and taken out; transmitting and receiving unit, for displaying a color region of an image to be sent to the cloud server intercepted.

[0029] 移动终端还包括:触摸显示屏,用于对于第三方没有预设边框的普通试纸,在触摸显示屏上显示符合试纸大小的取景框,提示用户用取景框套住整个试纸或者显色区域,并点击拍照按钮。 [0029] The mobile terminal further comprising: a touch screen, a predetermined frame for a third party without the ordinary paper, on the touch screen display in line with the viewfinder paper size, paper, or the entire trap the user is prompted with a color viewfinder area, and click the camera button.

[0030] 优选的,移动终端对截取的显色区图片进行标准化处理,将图片整理成统一的像素大小,或者将拍照时空间上或平面上偏移的图片旋转回来。 [0030] Preferably, the mobile terminal of the taken color image area is normalized, the image pixel size organized into a unified, or when taking offset in space or plane image rotation back.

[0031] 云端服务器还包括处理单元,用于设参考区(C线)的颜色值或灰度值为β,测试区(Τ线)的颜色值或灰度值为α,则通过α与β的相关比值运算得到样本浓度比γ。 [0031] The cloud server further comprises a processing unit for setting a reference color or gray region (C line) is beta], a color or gray test zone (Τ line) is [alpha], [alpha] and through beta] calculating correlation ratio obtained sample concentration ratio γ.

[0032] 对于非免疫层析试纸,通过其标准颜色空白垫或者采取边缘、卡壳、外包装的图像,计算颜色值或灰度值,作为参考区颜色值或灰度值β。 [0032] For non immunochromatographic test strip through which the color standard blank or take pad edge, stuck, overpack image, calculates the color or gray value, color or gray value as the reference region β.

[0033] 优选的,云端服务器还包括数据库,用于存储每个批次试纸的标准曲线,其中标准曲线是对应每批生产的试纸产品,使用标准浓度物质对该批次产品进行定标,通过测试区(Τ线)和控制区(C线)两者颜色值或灰度值的比值运算得出得出样本浓度比,根据样本浓度比值与标准物质真实浓度值的对应关系,产生该批次试纸的标准曲线,并将该标准曲线保存在云端服务器的数据库中;处理单元,根据库存留样的产品随时间变化的改变,更新标准曲线;根据移动终端传输的显色图像,计算出来的样本浓度比值(C、T比值),与该批次的标准曲线进行拟合运算,得出本次检验的真实浓度值。 [0033] Preferably, the cloud server further comprises a database for storing a standard curve for each lot of test strips, wherein a standard curve corresponding paper product from batch to batch, the concentration of the substance using the standard batch is scaled by test zone (Τ line) and the control zone (C line) calculating a ratio of both the color value or gray value derived samples obtained concentration ratio, based on the correspondence relationship between the concentration ratio of the standard sample substance concentration value true, generating the batch the sample color image of the mobile terminal transmission, calculated; standard curve test paper, and the calibration curve stored in the database in a cloud server; and a processing unit, according to the inventory of the product leaving the sample changes over time, updates the standard curve concentration ratio (C, T ratio), the standard curve fitting operation of the batch, the true concentration values ​​obtained in this test.

[0034] 本发明还提供一种基于移动终端摄像头的试纸读取与分析系统,用于计算试纸中样本的浓度值并分析测试结果,包括:移动终端,用于采集试纸图像,分析识别显色区的边缘,截取符合要求的显色区域,发送给云端服务器;云端服务器,用于根据接收的显色区图片,计算显色区图片中测试区(T线)和控制区(C线)的颜色值或灰度值,利用两者颜色值或灰度值的比值运算得出样本浓度比;对样本浓度比进行批次校准,将样本浓度比值带入该试纸批次的标准曲线进行拟合运算,计算出该样本中待检物的真实浓度值;判断该检测项目是否需要进行再次检测;如果无需再次检测,则将计算的样本真实浓度值与数据库中的数值范围进行比较,找出该浓度值对应的诊断结果以及相应的医疗建议;保存样本数值以及相应的医诊断结果,向用户返回检测结果、对应 [0034] The present invention further provides a mobile terminal strip reading camera and analysis system for calculating the concentration value of the sample strip and analysis of test results, comprising: a mobile terminal for collecting paper image, the color analysis identified marginal zone, taken in line with the requirements of the coloring region, is sent to the cloud server; cloud server according to the received color image regions, calculating image region in a color test region (T line) and the control zone (C line) color or gray value by calculating the ratio of both the color or gray value of concentration ratio obtained sample; sample batch calibration concentration ratio, the ratio of the concentration of the sample into the test strip batch standard curve fitting , and calculates the true value of the concentration of analyte in the sample; and determining whether the test items need to be detected again; if necessary to detect again, the true concentration value sample value range will be calculated in the database are compared, to find the diagnosis result corresponding to the density value and the corresponding medical advice; stored sample values ​​and the corresponding medical diagnosis, the detection result returned to the user, the corresponding 诊断结论以及建议;如果需要进行多次检测,则保存本次样本真实浓度值,向用户发送检测样本结果以及下次检测时间;定时器设定下一次检测的时间,并在定时器到达时向用户的移动终端发送提示消息,接收下一次检测的显色区图片。 Diagnostic conclusions and recommendations; if you need multiple tests, then save this sample concentration true value to send a test sample results and the next time the user is detected; setting a timer time detection, and when the timer reaches the user sends an alert message the mobile terminal, to accept the next color area detection image.

[0035] 本发明还提供一种基于移动终端摄像头和云端服务器的试纸读取与分析系统,用于计算试纸中样本的浓度值并分析测试结果,包括:移动终端,用于采集试纸图像,发送给云端服务器;云端服务器,用于接收试纸图片,分析识别显色区的边缘,截取符合要求的显色区域,计算显色区中测试区(T线)和控制区(C线)的颜色值或灰度值,利用两者颜色值或灰度值的比值得出样本浓度比;对样本浓度比进行批次校准,将样本浓度比值带入该试纸批次的标准曲线进行拟合运算,计算出该样本中待检物的真实浓度值;根据样本中待检物的真实浓度值查找匹配的检测结果,并将检测结果发送给移动终端。 [0035] The present invention further provides a test strip analysis system reads the camera and the mobile terminal based on a cloud server, used to calculate the concentration of the sample strips and analysis of test results, comprising: a mobile terminal, for acquiring image strip transmission Drive to the server; cloud server for receiving image strips, the edge analysis identified the color area, the interception of the region in line with the requirements of color, the color value of the color region calculated in the test zone (T line) and the control zone (C line) or gradation value, using a ratio of both the color or gray value of concentration ratio obtained sample; sample batch calibration concentration ratio, the ratio of the concentration of the sample into the test strip batch standard curve fitting, and calculates the true concentration of analyte in the sample; find matching detection result based on the true concentration of analyte in the sample, the detection result to the mobile terminal.

[0036] 本发明还一种用于试纸读取与分析的移动终端以及方法,包括:摄像头,用于获取试纸的识别码和图像;触摸显示屏,用于显示获取的图像内容,提示用户对准试纸的正确位置;处理单元,用于分析识别显色区的边缘,截取符合要求的显色区域;发送接收单元,用于向云端服务器发送识别码和显色区图片以及接收云端服务器发送的消息。 A mobile terminal and a method [0036] The present invention is also a method for reading and analysis of the test strips, comprising: a camera for acquiring the image and the identification code of the test strips; touch screen, for displaying the acquired image content, the user is prompted to the correct position of the quasi-paper; a processing unit for an edge region analysis identifies the color, the color area taken in line with the requirements; transmitting and receiving means for transmitting an identification code and a color image area and the cloud server receives the cloud sent from the server news.

[0037] 本发明还提供一种用于试纸读取与分析的云端服务器以及方法,包括:发送接收模块,用于接收试纸显色区图片,并向移动终端发送检测结果;数据库,用于存储各个检测项目不同批次的标准曲线,所述标准曲线用于表示测量值与真实浓度值的对应关系,并存储不同检测项目的真实浓度值对应的诊断结果与医疗建议;处理单元,用于分析显色区图片,计算显色区图片中的测试区(T线)和控制区(C线)的颜色值或灰度值,利用两者颜色值或灰度值的比值运算得出样本浓度比;对样本浓度比进行批次校准,将样本浓度比值带入该试纸批次的标准曲线进行拟合运算,计算出该样本中待检物的真实浓度值;根据样本中待检物的真实浓度值查找匹配的检测结果。 [0037] The present invention further provides a dipstick reading and analysis of the first server and a method, comprising: transmitting and receiving means for receiving image strips color area, to the mobile terminal sends a detection result; database for storing each different batches of test items a standard curve, said standard curve representing a correspondence relationship between the measured value and the true density value, and stores the density value corresponding to the true diagnosis and medical advice of different test items; a processing unit for analyzing color image area, calculating the test zone (T) for the color image region and the control region (C line) the color or gray value by calculating the ratio of both the color or gray value derived sample concentration ratio ; sample batch calibration concentration ratio, the ratio of the concentration of the sample into the test strip batch standard curve fitting calculation to calculate the true concentration of the analyte in the sample; the true concentration of analyte in the sample Find the value of the detection result of the match.

[0038](三)有益效果 [0038] (c) beneficial effect

[0039] 本发明的基于移动终端摄像头和云端服务器的试纸读取与分析方法与系统,相对于肉眼观察判断结果,用户不但可以得到更精准的试纸的定性结果,还可以实现定量的检测,而无需依赖专业设备,更可以得到专业的诊断结果和建议,此外云端服务器可以对试纸进行批次校准,测量结果更为精确。 [0039] dipstick reading and analysis method and system of the present invention is based on the mobile terminal camera and a cloud server, with respect to the naked eye determination result, the user can not only get a more accurate test strip qualitative results can also be achieved quantitative detection, and without relying on specialized equipment, but also to obtain professional diagnosis and recommendations, in addition to the cloud server may be batch calibration strip, more accurate measurement results. 用户可以建立自己的健康档案数据库,长期保存在云端服务器中,便于对结果进行长期动态观察。 Users can create their own health records database, long-term storage in the cloud server, facilitate long-term results of dynamic observation.

附图说明 BRIEF DESCRIPTION

[0040]图1是本发明的基于移动终端摄像头的试纸读取与分析系统的示意图。 [0040] FIG. 1 is a schematic dipstick reading Analysis System Based on the mobile terminal camera of the present invention.

[0041] 图2-1 — 2-3是本发明使用试纸的示意图。 [0041] FIG 2-1--2-3 is a schematic diagram of the present invention is the use of paper.

[0042] 图3是本发明移动终端的结构示意图。 [0042] FIG. 3 is a schematic diagram of a mobile terminal according to the present invention.

[0043] 图4是本发明移动终端获取试纸图像以及分析试纸图像的示意图。 [0043] FIG. 4 is a mobile terminal of the present invention and a schematic view of an image analysis test strips paper image acquisition.

[0044] 图5是本发明云端服务器的结构示意图。 [0044] FIG. 5 is a schematic diagram of the present invention, the cloud server.

[0045] 图6是本发明云端服务器中存储的标准曲线的示例图。 [0045] FIG. 6 shows an example of a standard curve of cloud storage server of the present invention.

[0046] 图7是本发明云端服务器对试纸图像进行计算和结果判定的流程图。 [0046] FIG. 7 is a flowchart of calculation and the result of the determination of the present invention is to strip the cloud server images.

[0047] 图8是本发明云端服务器对试纸图像进行计算和结果判定的另一个实施例的流程图。 Flowchart of [0047] FIG. 8 is a server of the present invention is to strip the cloud image and calculation result of the determination of another embodiment.

[0048] 图9是本发明云端服务器对试纸进行批次校准的流程图。 [0048] FIG. 9 is a flowchart of a cloud server according to the present invention is a batch calibration test strips.

具体实施方式 detailed description

[0049] 为使本发明的目的、技术方案和优点更加清楚明白,以下结合具体实施例,并参照附图,对本发明作进一步的详细说明。 [0049] To make the objectives, technical solutions, and advantages of the present invention will become more apparent hereinafter in conjunction with specific embodiments, and with reference to the accompanying drawings, the present invention will be further described in detail.

[0050] 如附图1所示,本发明的系统包括试纸1,移动终端2,云端服务器3和用户4。 [0050] As shown in Figure 1, the system according to the present invention comprises a strip 1, the mobile terminal 2, the cloud server 3 and the user 4. 移动终端2的摄像头301首先采集试纸I的识别码(步骤101),将识别码发送给云端服务器3 (步骤102),云端服务器3从数据库中调用试纸检测项目、批次等信息并返回给移动端(步骤103),移动终端2采集试纸的显色区图片(步骤104),并将显色区图片发送给云端服务器3 (步骤105),云端服务器根据接收的显色区图片计算样本的浓度值,得出检测结果,向用户4的移动终端2反馈测试结果和专业化建议并存储检测数据(步骤106)。 Camera mobile terminal 2 301 is acquired first identification code strip I (step 101), transmits the identification code to the cloud server 3 (step 102), the cloud server 3 calls the test paper items and batch information from the database and returned to the mobile end (step 103), the mobile terminal 2 acquired paper color image region (step 104), and transmits the image to a color region of the cloud server 3 (step 105), the server computing cloud concentration of the sample according to the received color image region value, the test results obtained, the test results to the mobile terminal 2 user feedback and professional recommendations 4 and stores the detected data (step 106). 可选的,云端服务器还包括云数据分析的功能,对检测的数据进行分析,例如某一地区的某一段时间疾病高发,或者某种兽药残留超标预警等等,还有客服系统,医生和专家在线指导咨询服务等等。 Optionally, the cloud server also includes functional analysis of cloud data, the data is analyzed to detect, for example, a certain period of time a certain area of ​​the high incidence of disease, or a veterinary drug residues exceeding the warning and so on, as well as customer service system, doctors and specialists online guidance counseling services.

[0051] 本发明采用的试纸可以是免疫层析试纸、化学显色试纸等能够显示颜色特征的试纸。 Test paper employed invention [0051] This may be an immunochromatographic test strip, test strips and other chemical capable of displaying color strip color features. 试纸I的结构如附图2所示。 Paper structure I as shown in FIG 2. 图2-1为免疫层析试纸的一个示例,控制显色条C线显示标准色条,C线代表控制区。 Figure 2-1 is an example of the immunochromatographic test strip, the control color bars show the standard color bar C-line, C line represents a control zone. T线代表测试区,检测显色条T线反应样本中待检物质的浓度,T线颜色的深浅与待检物质的浓度成比例关系,颜色越深代表样本中待检物的浓度越高。 Line represents a test region T, T strip line chromogenic reaction concentration in the sample of the substance to be detected, the higher the concentration and the depth to be proportional to the concentration of the test substance, the darker the color of a representative sample of the T-line of the analyte. 夕卜界的环境光线有很多不同,但是T线与C线都是处在同一个环境光线下,并且C线代表的色深是标准色深,C线代表控制区,从而以C线作为参考即可准确得出T线的色深。 Bu Xi sector many different ambient light, but the T line and the C line are at the same ambient light, and the color C line represents the standard color depth is deep, the line representing the control region C so as to reference line C to obtain accurate color T lines deep. 具体的样本浓度定量方法将在下文有关云端服务器3的介绍中详细阐述。 The specific concentration of the sample quantification method described in detail hereinafter, the server 3 about the cloud. 加样孔S用于放置被测样本。 Sample hole S for placing the sample under test. 可选的,有些试纸也可以没有加样孔S,可以是吸样棒或者还可以将样本直接至于显色区。 Alternatively, some test strips can not sample hole S, it may be a rod or aspirating a sample may also be directly As color region. 识别码201可以是二维码、条形码或其他用于识别的编码方式,用于区分试纸的类型和批次信息,识别码可以位于试纸条及外壳上的任意位置。 Identifier 201 may be a two-dimensional codes, bar codes or other identification for encoding, and for distinguishing the type of test strip lot information identification code can be located anywhere on the test strip and housing. 此外,可选的,二维码可以存在于试条上、包装袋上、包装盒上,或某个附件中。 In addition, an optional two-dimensional code may be present on the strip, the bags, the box, or in an attachment. 如图2-1所示可以位于显色条上方,但并不局限于此,本领域技术人员可以理解,识别码也可以位于显色条下方或侧方任意位置。 As shown in Figure 2-1 it may be located above the color bar, but not limited to, those skilled in the art will appreciate, the identification code may be located in a color bar on the bottom side or anywhere. 如附图2-1所示,虚线框202内为显色区域,边框可以是预先设定的颜色,也可以通过将边框202内外采用不同颜色,通过色差来区分。 As shown in Figure 2-1, the dashed box 202 is a color area, the border may be predetermined color drawings, the inner and outer frame can also be of different colors 202, distinguished by color.

[0052] 在另一个可选的方案中,试纸或外壳上设有定位点,用于定位试纸的显色区。 [0052] In another alternative embodiment, the anchor point is provided on the housing or paper, paper color for positioning region. 定位点可以是喷涂或者直接制作在试纸或外壳上,可以是一个、二个或多个。 Or anchor point may be sprayed directly formed on paper or housing, it may be one, two or more. 摄像头捕获该定位点并以该定位点形成的坐标系对显色框进行定位。 The camera captures the anchor point and anchor point formed on the color coordinate frame positioned.

[0053] 另外,本发明的试纸也可以采用其他非免疫层析试纸,如图2-2和2-3所示,图2-2为尿十项试纸,图2-3为其他化学试纸,此类试纸与层析试纸相同的地方是都是基于颜色反应的方式,不同之处在于化学试纸没有C线作为参考,而是采用其它形式的颜色补偿空白垫等来作为参照。 [0053] Further, test strip of the present invention may be employed other non immunochromatographic test strip, as shown in Figure 2-2 and 2-3, FIG. 2-2 ten urine test paper, other chemical test strip of FIG. 2-3, such a chromatographic strip is strip the same place are based on a color reaction manner, except that no chemical test strip as a reference line C, instead of using other forms of color compensating pads and the like as a reference blank.

[0054] 移动终纟而2的结构如附图3所不。 [0054] Si and the mobile terminal 2 as the structure in Figure 3 are not. 移动终纟而2包括摄像头301,触換显不屏302,发送接收单元303,处理单元304。 Si and mobile terminal 2 includes a camera 301, a touch screen 302 does not change significantly, transmission and reception unit 303, the processing unit 304. 摄像头301用于获取试纸I的识别码和图像,触摸显示屏302可以显示获取的图像内容,并指导用户对准试纸的正确位置,处理单元304用于控制摄像头301以及触摸屏显示器302获取试纸图像,分析识别显色区的边缘,截取符合要求的显色区域,发送接收单元303用于向云端服务器3发送显色区图片、用户个人信息等以及接收云端服务器3发送的消息。 Paper camera 301 for acquiring an identification code and an image I, touch screen 302 may display the acquired image content, and a user guide strip correctly aligned position, the processing unit 304 for controlling the camera 301 and the touch screen display 302 acquires image strips, edge analysis identified the color region, the color taken to meet the requirements of the region, sending a message reception unit 303 for transmitting a color image area, the user personal information to the cloud server 3 and transmitted from the server 3 receives the cloud. 用户可以通过移动终端的触摸显示屏302随时查看每次检测结果以及自己的健康档案。 Users can touch the display screen 302 of the mobile terminal at any time to see the results of each test as well as their health records.

[0055] 附图4示出了移动终端2获取试纸图像以及分析试纸图像的实施方式。 [0055] Figure 4 illustrates a mobile terminal acquires and analyzes images dipstick test strips image in the embodiment 2. 如附图4所示,在步骤401,摄像头301扫描试纸的识别码,将获取的识别码信息发送给云端服务器 As shown in the drawing, at step 401, the imaging head 301 scans paper identification code, the identification code of the acquired information to the cloud server 4

3。 3. 在步骤402,移动终端2接收云端服务器返回试纸检测项目、批次或者校准曲线等信息。 In step 402, the mobile terminal 2 receives first server returns information item test paper, or batch calibration curve.

[0056] 另一个可以替代的实施方式中,对于第三方提供的没有识别码的普通试纸,移动终端的触摸显示屏302可以提示用户选择试纸类型、检测项目,显示屏302可以提供多个选择框,用户手动选择试纸的类型,输入批次信息,并将用户选择的试纸类型发送给云端服务器3。 [0056] Another possible alternative embodiment, the identification code of ordinary paper is not provided by third parties, the touch screen of the mobile terminal 302 may prompt the user to select the type of test strips, test items, the display 302 may provide a plurality of selection box , the user manually select the type of test strips, the batch input information, and sends the paper type selected by the user to the cloud server 3.

[0057] 在步骤403,摄像头采集整个试纸条的图像。 [0057] In step 403, the camera capture an image of the entire strip.

[0058] 在步骤404,处理单元通过颜色和边缘分析识别,通过预先设定试纸的卡壳与显色区域的色差,找到预先设定的边框,选定该区域,即试纸的显色区框202。 [0058] In step 404, the processing unit analyzes and identified by color edge, by setting in advance stuck to paper color of the coloring region to find predetermined frame, the selected region, i.e., the color frame region 202 dipstick . 对于设有定位点的试纸的实施方案,通过预设的定位点彼此之间的像素、距离比例关系,在扫描的过程中,去除干扰和错误的识别点,筛选出定位点的位置。 For the embodiment of a positioning strip point, through a preset point positioned between each pixel, the ratio between the distance, in the scanning process to remove noise and erroneous identification point, the position of the anchor point selected. 由于定位点与结果判定区域的位置相对固定,所以通过定位点可以精确定位出结果判定区域的位置和水平、垂直方向的位置。 Since the result of the decision point and the position of the positioning region is relatively fixed, it can be precisely positioned by a positioning result of the decision point and the position of the horizontal area, vertical position.

[0059] 在步骤405,在该区域中找出符合比例要求的显色区域,并截取出来。 [0059] In step 405, identify the color area according to the proportion required in this region, and taken out. 无论是通过定位点的识别算法,还是通过试纸卡壳和显色区域之间的颜色差别的算法,这两种边缘识另IJ算法,在制作试纸、制作塑料卡壳、或者印刷制作定位点时候,都会设置好预先的比例,在获取图像的时,只要找到了符合已知设置的比例关系参数,也就意味着确定了目的显色区域,基于上述两个算法,都能够准确的确定目的显色区域。 Recognition algorithm whether an anchor point, or the color difference between the color area and paper jams algorithm, identifying the other two edges IJ algorithm, in the production of paper, production of plastic stuck, or print production setpoint that they will the proportion of pre-set, when acquiring images, as long as the ratio between the parameter settings found in line with the known, which means the purpose of determining the color area, based on the above two algorithms are able to accurately determine the purpose of the coloring region .

[0060] 对于第三方没有预设边框的普通试纸,在显示屏上有符合试纸大小的取景框,用户需要用取景框套住整个试纸或者显色区域,触发自动拍照或者点击拍照按钮,移动端拍照后会弹出一个根据上述的边缘算法自动识别的边缘的图片和识别好的剪裁框,然后要求用户手工确认边缘识别是否正确,如果不正确可手工拖拽剪裁框的边缘来修正,然后点击确认,则移动端开始进行图像中显色区域的分析和计算,最终返回用户结果。 [0060] For the third party is not preset borders ordinary paper, there viewfinder in line with the size of the paper on the screen, the user needs to entangle the entire area with paper or color viewfinder, trigger automatic camera to take pictures or click the button to move the end pictures will pop up after a good trimming frame according to the picture above the edge of the edge of the algorithm automatically identifies and identification, and then ask the user to manually confirm edge identification is correct, if not correct can manually drag the trimming frame edge to correct, and then click OK , the mobile terminal starts analysis and calculation of the color image area, the final results returned to the user.

[0061] 为了增加检测的准确性,可选的,在步骤406,移动终端还对截取的图片进行标准化处理,将图片的有效结果判定区域截取出来,同时整理成统一的像素大小,还包括通过算法的分析,将拍照时空间上或平面上偏移的图片旋转回来。 [0061] To increase the detection accuracy, optionally, at step 406, the mobile terminal also taken image is normalized, the effective result of the determination image area taken out, and the adjustment into uniform pixel size by further comprising analysis algorithms will shift when taking pictures of space on the plane or rotate the picture back.

[0062] 可选的,步骤404-406也可在服务器端完成,在步骤403摄像头采集整个试纸条图像后即发送给云端服务器,由服务器完成步骤404-406。 [0062] Optionally, steps 404-406 may be completed at the server side, at step 403 captured by the camera is sent to the server cloud image after the entire test strip, by the server to complete steps 404-406.

[0063] 云端服务器的结构如图5所示。 Structure [0063] FIG. 5 shows a cloud server. 发送接收模块501用于与移动终端发送和接收信息。 Transceiver module 501 for transmitting and receiving information with the mobile terminal. 处理单元502用于分析图像、数值计算、批次校准、结果匹配等功能。 Processing unit 502 for analyzing the image, numerical calculation, batch calibration results matching functions. 数据库503存储了各个检测项目不同批次的标准曲线,即测量的样本浓度比值与真实浓度值的对应关系,同时,数据库503还存储了不同检测项目的浓度值对应的诊断结果与医疗建议,以及针对用户每次测量的样本浓度值,对每个用户建立一个健康档案。 Database 503 stores various test items of different batches of the standard curve, i.e. corresponding relationship between the concentration ratio of the sample measured values ​​of the true concentration, while database 503 also stores the diagnosis result corresponding to different values ​​of the concentration of test items and medical advice, and sample concentration values ​​for each measurement user, the establishment of a health record for each user.

[0064] 图6示出了数据库503中存储的某一个批次的试纸标准曲线示意图。 [0064] FIG. 6 shows a schematic view of a standard curve for a strip of a batch database 503 is stored. 在诊断试剂行业,所用的原料比如抗体等,均为生物活性物,每批之间会有活性等的差别,所以每个批次之间存在批间差。 In the diagnostic reagent industry, the raw materials used, such as antibodies, are biologically active, there will be differences between the activity of each batch, there is a difference between the inter-batches each batch. 所谓标准曲线,也就是测量值与真实浓度值的对应关系。 The so-called standard curve, i.e. the measurement value and the corresponding relationship between the true concentration value. 如图6所示为某个批次的试纸标准曲线示意图,横轴方向代表真实浓度值X,纵轴方向代表样本浓度比γ,云端服务器计算得出样本浓度比值γ 1、γ2等,将γ 1、γ 2代入标准曲线中就能对应查出真实浓度值Xl和Χ2等。 6 shows a schematic view of a test strip batch standard curve, the concentration of the horizontal axis represent the true value X, the longitudinal direction of a representative sample drawn gamma] concentration, concentration of the sample than the server computing cloud ratios γ 1, γ2 and the like, the gamma] 1, γ 2 can be substituted into the standard curve corresponding to the true concentration value Xl and isolated Χ2 like.

[0065] 参考图7,说明本发明的云端服务器3对试纸图像进行计算和结果判定的方法步骤。 [0065] Referring to FIG. 7, the cloud server 3 of the invention and a test paper method of calculating the image of the result of the determination step. 在步骤701,云端服务器接收移动终端发送的试纸识别信息和显色图片。 In step 701, the cloud server receives identification information and a color paper images transmitted from the user. 在步骤702,对显色图片进行色彩、灰度分析,转化成相应的数值。 At step 702, the color picture on the color, grayscale analysis, converted to the corresponding value. 在步骤703,利用转化成颜色值或灰度值的C线与T线的值,计算样本含量。 At step 703, using the color value converted to a gray scale value or the line C and the line T, a sample size calculation. 设C线的颜色值或灰度值为β,T线的颜色值或灰度值为α,则通过α与β的相关比值运算得到样本浓度比γ。 Color or gray value of the line set C β, T-line color or gray value of α, γ than the concentration of the sample is obtained by calculating the ratio of [alpha] associated with the beta]. 根据不同的检测项目情况,具体的运算方式有所不同。 Depending on the test items, the specific calculation differently. 例如,该运算可以为α/β或者β/α、α2/β2、(a 2+5)/(β 2+6)等,其核心特征为该运算中包含有比值运算,通过该比值运算一定程度上消除环境因素造成的偏移。 For example, this operation may be α / β or β / α, α2 / β2, (a 2 + 5) / (β 2 + 6) and the like, which comprises a core characterized in that there is a ratio calculation operation, by calculating the ratio constant eliminate the offset caused by environmental factors extent.

[0066] 对于非层析试纸,结果判定是取决于最终化学试纸反应区域的色彩变化,所以其不具备C线和T线的概念,在这种实施例中,通过其标准颜色空白垫或者采取边缘、卡壳、夕卜包装的图像等,作为C线校准颜色值或灰度值β。 [0066] For non-chromatography test strip changes color depending on the result of the determination is the final chemical test strip reaction region, so it does not have the concept of the C-line and the line T, in such an embodiment, gaps through which pad or take a standard color edge, stuck, Xi Bu packaging images, as C-line calibration color or gray value β. 如图2-2所示,包括不限于两个色块的中间区域、试纸的底端空白部分,试纸塑料卡壳部分、试纸外包装某一部分等区域采集作为C线的替代品参与计算。 Shown in Figure 2-2, comprises two patches is not limited to the middle region of the bottom blank part of the paper, paper plastic card housing portion, a portion of the packaging paper and the like is calculated as the acquisition region involved in alternative C-line. 通过将显色色块与空白部分的颜色值或灰度值进行比值预算,进一步来计算样本浓度比值。 Budget ratio for the color patch by the color or gray value of the blank portion, further calculates the ratio of the concentration of the sample.

[0067] 在步骤704,将得到的样本浓度比值γ代入服务器数据库503中存储的该检测项目以及批次产品中测量结果与真实浓度的标准曲线进行拟合计算,得出该次检测的样品真实浓度值。 [0067] In step 704, the resulting sample concentration ratio is substituted into γ server database 503 stored in the standard curve and test items and the real measurement result of the concentration of the fitting calculation in a batch, the sample is obtained real-time detection of concentration values.

[0068] 在步骤705,将计算的待检物的真实浓度值与数据库中的数值范围进行比较,找出该浓度值对应的诊断结果以及相应的医疗建议。 [0068] In step 705, the value range of the true concentration value calculated with a database of test substances are compared, to find the values ​​corresponding to the concentration of the diagnosis result and the corresponding medical advice. 或者对于非医疗检测项目,数据库中也存储了浓度值对应的判断结果,例如是否甲醛含量超标、农药残留量等级等判断结果,找出该浓度值对应的判别结果。 For the detection or non-medical items, the database also stores the determination result of the density values ​​corresponding to, for example, if excessive levels of formaldehyde, and the like pesticide residues level determination result, to find out the result of the determination values ​​corresponding to the concentration.

[0069] 在步骤706,保存待检物的真实浓度值以及相应的判别结果,向移动终端发送检测结果、对应的诊断结论以及建议。 [0069] In step 706, saving the true analyte concentration value and the corresponding determination result, transmits a detection result to the mobile terminal, corresponding to the diagnoses and recommendations.

[0070] 在另一个可替换的实施例中,步骤702-704可以在移动终端中实现,移动终端扫描试纸的识别码,将识别码发送给云端服务器后,云端服务器返回识别码标识的试纸类型、批次以及标准曲线,移动终端采集试纸图像、分析显色区边缘并截取显色区域(参见上文中对附图4的描述),并不需要再发送给云端服务器,而是直接完成步骤702-704,即在移动终端中计算测量值和进行批次校准,并计算得出试纸检测待检物的浓度数值,再进行后续处理。 [0070], steps 702-704 may be implemented in a further alternative embodiment in a mobile terminal, the mobile terminal scans the test paper identification code, the identification code will be sent to the server after the cloud, the cloud server returns the paper type identification code identifies , batch and standard curve, the mobile terminal strip image acquisition, analysis and intercept the edge zone color color region (see the above description of FIG. 4), does not need to be sent to the server cloud, but directly to step 702 to complete the -704, i.e., calculated in the mobile terminal and the measurements for batch calibration, and the calculated value of the concentration of the analyte test strip, before subsequent handling. 例如,移动终端可以直接完成后续的步骤705-706,也可以再将计算的试纸的浓度值发送给云端服务器,由云端服务器完成步骤705-706。 For example, the mobile terminal can be done directly in the subsequent steps 705-706, then the concentration may be calculated value to the test paper cloud server, performed by steps 705-706 cloud server.

[0071] 图8是本发明的云端服务器3对试纸图像进行计算和结果判定的另一个实施例。 [0071] FIG. 8 is a cloud server 3 of the invention and a test paper image calculation result of the determination of another embodiment. 其中,步骤801-804与附图7中的701-704步骤相同。 Wherein, in step 801-804 and 7701-704 drawings the same step. 在步骤805,判断该检测项目是否需要进行再次检测,如果无需再次检测,则进入步骤806,将计算的样本浓度比与数据库中的数值范围进行比较,找出该含量值对应的诊断结果以及相应的医疗建议。 In step 805, it is determined whether the detected item needs to be detected again, if necessary to detect again, the process proceeds to step 806, the calculated ratio of the concentration of the sample is compared to a value range of the database to find out the content of the diagnosis results corresponding to the respective values ​​and medical advice. 在步骤807,保存样本数值以及相应的医诊断结果,向用户返回检测结果、对应的诊断结论以及建议。 In step 807, the stored sample values ​​and the corresponding medical diagnosis, the detection result returned to the user, corresponding to the diagnoses and recommendations. 如果需要进行多次检测,则进入步骤808,保存本次样本数值,向移动终端发送检测样本结果以及下次检测时间。 If multiple tests is required, the process proceeds to step 808, to save the current sample values, and transmits the detection result of the next sample detection time to the mobile terminal. 在步骤809,定时器设定下一次检测的时间,并在定时器到达时向用户的移动终端发送提示消息,并返回到步骤801。 At the time of the detection at step 809, timer setting, and sends an alert message to the user of the mobile terminal when the timer expires, and returns to step 801.

[0072] 参考图9,说明本发明的云端服务器3对试纸进行批次校准的方法。 [0072] Referring to FIG 9, a method according to the present invention, the cloud server 3 Batch calibration test paper. 在步骤901,对应每批生产的试纸产品,使用标准浓度物质对该批次产品进行定标,得出C、T比值与标准物质浓度的对应关系,产生标准曲线图图6所示,并将该标准曲线保存在云端服务器的数据库503中。 In step 901, the corresponding batch production of paper products, the concentration of the substance using the standard batch scaling, C obtained correspondence relationship between the ratio of T standard concentration of a substance, a standard curve is generated as shown in FIG. 6, and the calibration curve is stored in the database server 503 in the cloud. 在步骤902,云端服务器根据库存留样的产品随时间变化的改变,适时更新标准曲线。 At 902, the cloud server changes over time according to remaining inventory changes step-like products, updated as appropriate standard curve. 在步骤903,根据用户移动终端传输的显色图像,计算出来的样本浓度比(C、T比值),与标准曲线进行拟合运算,得出该次检验的真实浓度值。 In step 903, a color image according to the user's mobile terminal transmission, the calculated sample concentrations fitting operation ratio (C, T ratio), the standard curve, obtained the true value of the concentration of the test times. 通过本发明的方法,由于云端服务器中存储了每个批次的产品的标准曲线,从而消除了不同批次产品的批间差,得到的测量结果更加准确。 By the method of the present invention, the cloud storage server standard curve for each batch of products, eliminating between batches of different lots difference, the more accurate the measurements obtained. 由于本发明的批次校准曲线存储于云端服务器上,并且可以随时根据留样产品的时间变化进行校准曲线的更新,最大程度上消除了检测产品的批间差,保证了检测结果的精确性。 Since a calibration curve stored in the batch of the present invention in the cloud server, and may be updated at any time based on a calibration curve left like product, eliminating the difference between product batches detecting the maximum extent, to ensure the accuracy of test results.

[0073] 以宫外孕检测为例,移动终端通过扫描识别码或者人工输入方式获知该检测的项目,并提示用户在正确的时间范围内使用晨尿进行测试。 [0073] In an example detect ectopic pregnancy, the mobile terminals know the item identification code detected by scanning or manual input mode, and prompts the user to use the morning urine test at the correct time. 在第一次晨尿测定后,移动终端将显色图片发送到云端服务器,云端服务器接收试纸的显色图片,进行批次校准并计算出第一次晨尿样本的HCG浓度值,判断还需要进行下一次检测,向用户返回HCG检测结果以及提示信息“请在**日早晨取晨尿继续测试”,提示用户在48小时后进行再次测试,云端服务器设置定时器,用户在48小时到达时再次检使用晨尿进行测试,重复前一次测试的步骤,云端服务器接收第二次显色图片,计算HCG浓度,计算HCG浓度,判断是否还需要再进行检测,根据两次检测的结果,向用户返回两次HCG的检测结果以及诊断信息“根据本次测量结果,有宫外孕的风险,请及时去医院就诊”或者“检测结果正常”。 In the next morning after the first measurement of urine, the mobile terminal transmits the color image server to the cloud, the cloud server receives paper color image, and calculates a calibration Batch HCG concentration of the present values ​​of the first morning urine specimens, the determination needs next conduct a test, return HCG detection results and prompt information to the user, "Please take morning urine in the morning to continue testing **", prompting the user to test again after 48 hours, set the timer cloud server, the user arrives at 48 hours again using morning urine test sample, the test was repeated once prior to the step of the cloud server receives the second color image, calculating the concentration of HCG, HCG concentration is calculated, still need to be detected is determined whether or not, based on the results of two tests, the user return detection results of the two HCG and diagnostic information, "according to the measurement results, the risk of ectopic pregnancy, please go to the hospital" or "Test results normal." 如果用户在48小时之后的3个小时内均未进行第二次晨尿测试,则向用户发送消息“本次测定无效,建议您到医院进行检查”。 Urine tests were not next morning if a second user within three hours after 48 hours, then send messages to users "This measurement is invalid, we recommend you to the hospital for examination." 与此同时,还可以向用户发送宫外孕相关的参考信息。 At the same time, you can also send an ectopic pregnancy-related reference information to the user.

[0074] 通过本发明的方法与系统,用户可以通过自己的移动终端简单而准确的进行样本测试,既可以做定性检测也可以做定量检测,免去了反复到医院就诊的劳累与风险,轻松实现家庭医疗。 [0074] By the method and system of the present invention, the user can own mobile terminal is simple and accurate test sample, either qualitative detection may also be quantitatively detected, eliminating the need for repeated visits to the hospital and risk of fatigue, easily for home health care. 当需要进行多次测试时,能够通过移动终端获得提醒,避免错过最佳测试时间。 When the need for multiple tests can be alerted by the mobile terminal, to avoid missing the best test of time. 医生也可以在没有医院专业设备的时,在医院以外的情况实现移动医疗。 Doctors also can in the absence of specialized hospital equipment, in the case of non-hospital mobile medical implement.

[0075] 以上所述的具体实施例,对本发明的目的、技术方案和有益效果进行了进一步详细说明,应理解的是,以上所述仅为本发明的具体实施例而已,并不用于限制本发明,凡在本发明的精神和原则之内,所做的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。 [0075] The foregoing specific embodiments of the object, technical solutions, and advantages of the invention will be further described in detail, it should be understood that the above descriptions are merely embodiments of the present invention, but not intended to limit the present invention, all within the spirit and principle of the present invention, any changes made, equivalent substitutions and improvements should be included within the scope of the present invention.

Claims (44)

  1. 1.一种基于移动终端摄像头和云端服务器的试纸读取与分析方法,用于计算试纸所检测样本中待检物的浓度值并分析测试结果,其特征在于包括以下步骤: A)移动终端摄像头采集试纸图像,分析识别显色区的边缘,截取符合要求的显色区域; B)计算显色区图片中的测试区(T线)和控制区(C线)的颜色值或灰度值,利用两者颜色值或灰度值的比值运算得到样本浓度比; C)对样本浓度比进行批次校准,将样本浓度比值代入该试纸批次的标准曲线进行拟合运算,计算出该样本中待检物的真实浓度值; D)根据样本中待检物真实浓度值查找匹配的检测结果,并将检测结果发送给移动终端。 A method of reading and analysis of test strips based on cameras and mobile terminal cloud server, used to calculate the value of the sample strip in the concentration of the analyte to detect and analyze the test result, characterized by comprising the following steps: A) a mobile terminal camera paper image acquisition, analysis to identify the edges of the color region, the color taken meet regional requirements; a color or gray value B) calculating the test zone (T) for the color image region and the control region (C line), calculation using a ratio of both the color or gray value of a sample obtained concentration ratio; C) sample batches calibration concentration ratio, the concentration ratio is substituted into the sample standard curve fitting the strip batch operation, is calculated in the sample the true concentration of analyte; D) the sample to be the true analyte concentration value to find the detection result of the matching, the detection result to the mobile terminal.
  2. 2.如权利要求1所述的方法,其特征在于: 在步骤A)移动终端摄像头采集试纸图像之前,摄像头首先采集试纸的识别码,将识别码发送给云端服务器,云端服务器从数据库中调用试纸检测项目、批次等信息并返回给移动终端。 2. A method according to claim 1, wherein: prior to step A) of the mobile terminal camera capture strip images, the camera is acquired first identification code strip, and transmits the identification code to the cloud server cloud server calls the strip from the database test items, and batch information returned to the mobile terminal.
  3. 3.如权利要求1所述的方法,其特征在于: 在步骤A)移动终端摄像头采集试纸图像之前,提示用户在移动终端手工选择输入试纸的类别、批次信息,发送给云端服务器。 3. The method according to claim 1, wherein: prior to step A) of the mobile terminal strip camera capture an image, the user is prompted to select the input in a mobile terminal manual paper type, batch information, the server transmits to the cloud.
  4. 4.如权利要求1所述的方法,其特征在于: 步骤A)进一步包括: 摄像头采集整个试纸条的图像; 颜色和边缘分析识别,通过预先设定试纸的卡壳与显色区域的色差,找到预先设定的边框,选定该区域; 在该区域中找出符合预先设定比例要求的区域作为显色区域,并截取出来。 4. The method according to claim 1, characterized by the steps of: A) further comprising: a test strip camera capture the entire image; and an edge color analysis identified, by setting in advance the paper jam and color the coloring region, found predetermined frame, the selected region; identify the preset area ratio compliance requirements in this area as a color area, and taken out.
  5. 5.如权利要求1所述的方法,其特征在于: 步骤A)进一步包括: 摄像头采集整个试纸条的图像; 筛选定位点的位置,通过定位点定位显色区域的位置和水平、垂直方向的位置; 在该区域中找出符合预先设定比例要求的区域作为显色区域,并截取出来。 5. The method according to claim 1, characterized by the steps of: A) further comprising: a camera to capture images of the entire test strip; screening anchor point position, substantially horizontal position and the color area is positioned by the positioning point, in the vertical direction position; find meet in the region of a predetermined area ratio requirement as a color area, and taken out.
  6. 6.如权利要求1所述的方法,其特征在于: 步骤A)进一步包括: 对于第三方没有预设边框的普通试纸,在显示屏上有符合试纸大小的取景框,提示用户用取景框套住整个试纸或者显色区域,并点击拍照按钮。 6. The method according to claim 1, characterized by the steps of: A) further comprising: a third-party no default common border strip, there are in line with the viewfinder paper size on the display screen, the user is prompted with a viewfinder sleeve live throughout dipstick or color area, and click the camera button.
  7. 7.如权利要求1-6所述的方法,其特征在于: 步骤A)进一步包括: 移动终端对截取的显色区图片进行标准化处理,将图片整理成统一的像素大小,或者将拍照时空间上或平面上偏移的图片旋转回来。 7. The method according to claims 1-6, characterized in that: step A) further comprises: a mobile terminal taken color image area is normalized, the image pixel size organized into a unified, or photograph space offset or upper back plane image rotation.
  8. 8.如权利要求1-6所述的方法,其特征在于: 步骤B)进一步包括: 设参考区(C线)的颜色值或灰度值为β,测试区(Τ线)的颜色值或灰度值为α,通过α与β的相关比值运算得到样本浓度比γ。 8. The method as claimed in claim 1-6, wherein: step B) further comprises: setting a reference color or gray region (C line) is beta], test zone (Τ line) or color value gray value α, γ than the concentration of the sample obtained by the correlation calculating the ratio of [alpha] and β.
  9. 9.如权利要求8所述的方法,其特征在于: 对于非免疫层析试纸,通过其标准颜色空白垫或者采取边缘、卡壳、外包装的图像,计算颜色值或灰度值,作为参考区颜色值或灰度值β。 9. The method according to claim 8, wherein: the non-immunochromatographic test strip through which the color standard blank or take pad edge, stuck, overpack image, a color or gray value is calculated as the reference region color or gray value β.
  10. 10.如权利要求1所述的方法,特征在于: 步骤C)进一步包括: 对应每批生产的试纸产品,使用标准浓度物质对该批次产品进行定标,通过测试区(Τ线)和控制区(C线)两者颜色值或灰度值的比值运算得出样本浓度比,根据样本浓度比值与标准物质真实浓度值的对应关系,产生该批次试纸的标准曲线,并将该标准曲线保存在云端服务器的数据库中; 根据库存留样的产品随时间变化的改变,更新标准曲线; 根据移动终端传输的显色图像,计算出来的样本浓度比(C、T比值),与该批次的标准曲线进行拟合运算,得出本次检验中待检物质的真实浓度值。 10. The method according to claim 1, wherein: Step C) further comprising: a corresponding paper product from batch to batch, the concentration of the substance using the standard batch is scaled by a test zone (Τ line) and control zone (C line) calculating the ratio of both the color or gray value derived sample concentration ratio, based on the correspondence relationship between the concentration ratio of the standard sample substance concentration value true, generating a standard curve of the batch of test strips, and the standard curve stored in the database server in the cloud; product retention samples according to the inventory changes with time change, updates the standard curve; mobile terminal in accordance with the color image transfer, the calculated ratio of the concentration of the sample (C, T ratio), with the batch the standard curve fitting operation, the true concentration values ​​obtained in this test to be the test substance.
  11. 11.如权利要求1所述的方法,其特征在于: 步骤C)之后还包括以下步骤: 判断该检测项目是否需要进行再次检测; 如果无需再次检测,则将计算的样本真实浓度值与数据库中的数值范围进行比较,找出该浓度值对应的诊断结果以及相应的医疗建议;保存样本数值以及相应的检测结果,向移动终端发送检测结果、对应的诊断结论以及建议; 如果需要进行多次检测,则保存本次样本真实浓度值,向移动终端发送检测结果以及下次检测时间;定时器设定下一次检测的时间,并在定时器到达时向移动终端发送提示消息,并返回到步骤B)。 11. The method according to claim 1, wherein: after step C) further comprises the step of: determining whether the detected item needs to be detected again; if necessary to detect again, then calculate the true concentration of the sample values ​​in the database comparing numerical range, to find the density value corresponding to the diagnosis and the corresponding medical advice; stored sample values ​​and the corresponding detection result, transmits a detection result to the mobile terminal, the corresponding diagnostic conclusions and recommendations; detected several times if necessary , save the current sample real density value, and transmits the detection result to the next time the mobile terminal is detected; the detection of a timer set time, and sends an alert message to the mobile terminal when the timer expires, and returning to step B ).
  12. 12.—种基于移动终端摄像头和云端服务器的试纸读取与分析系统,用于计算试纸中样本的浓度值并分析测试结果,其特征在于包括: 移动终端,用于采集试纸图像,分析识别显色区的边缘,截取符合要求的显色区域,发送给云端服务器; 云端服务器,用于: 接收和分析显色区图片,计算显色区图片中的测试区(Τ线)和控制区(C线)的颜色值或灰度值,利用两者颜色值或灰度值的比值运算得出样本浓度比; 对样本浓度比进行批次校准,将样本浓度比值代入该试纸批次的标准曲线进行拟合运算,计算出该样本中待检物的真实浓度值; 根据样本中待检物真实浓度值查找匹配的检测结果,并将检测结果发送给移动终端。 12.- species strip analysis system reads the camera and the mobile terminal based on a cloud server, used to calculate the concentration of the sample strip and analyze the test results, characterized by comprising: a mobile terminal for image capture strip, identified significant the edge of the color region, the color taken to meet the requirements of the region, to a cloud server; cloud server, for: receiving and analyzing a color image area, the test area is calculated significantly (Τ line) color region in the image and the control zone (C line) the color or gray value by calculating the ratio of both the color or gray value of concentration ratio obtained sample; sample batch calibration concentration ratio, the concentration ratio is substituted into the sample standard curve of the strip is batch fitting operation to calculate the true concentration of the analyte in the sample; in accordance with the sample to be true analyte concentration value to find the detection result of the matching, the detection result to the mobile terminal.
  13. 13.如权利要求12所述的系统,其特征在于: 用于测试的试纸包括免疫层析试纸或化学显色试纸,所述试纸包括识别码,所述识别码包括二维码、条形码或其他用于识别的编码方式,用于区分试纸的类型和批次信息。 13. The system of claim 12, wherein: the test strip for immunochromatographic test strip comprising a chemical or a color strip, said strip comprising an identification code, the identification code comprises a two-dimensional codes, bar codes or other for identifying a coding mode, information for distinguishing the type and batch of test strips.
  14. 14.如权利要求12-13所述的系统,其特征在于: 移动终端采集试纸图像之前,首先采集试纸的识别码,将识别码发送给云端服务器,云端服务器从数据库中调用试纸检测项目、批次等信息暂存并返回给移动端。 14. The system according to claim 12-13, wherein: the mobile terminal prior to image capture strip, strip acquired first identification code, the identification code will be sent to the server cloud, the cloud server calls the test paper items from the database, the batch inferior and temporary information returned to the mobile terminal.
  15. 15.如权利要求12所述的系统,其特征在于: 移动终端采集试纸图像之前,提示用户在移动终端手工选择输入试纸的类别、批次信息,发送给云端服务器。 15. The system of claim 12, wherein: the mobile terminal prior to image capture strip, the user is prompted to select the input paper type, batch information in a mobile terminal hand, the server transmits to the cloud.
  16. 16.如权利要求12所述的系统,其特征在于: 移动终端还包括: 摄像头,用于采集整个试纸条的图像; 处理单元,用于: 颜色和边缘分析识别,通过预先设定试纸的卡壳与显色区域的色差,找到预先设定的边框,选定该区域, 在该区域中找出符合预先设定比例要求的区域作为显色区域,并截取出来; 发送接收单元,用于将截取的显色区域图像发送给云端服务器。 Processing means for; camera for capturing the entire image of the test strip:: edge analysis and color recognition, by presetting the strip 16. The system as claimed in claim 12, wherein: the mobile terminal further comprises stuck and color of the coloring region, set in advance to find the border, the selected region, to identify the region in line with a predetermined ratio as required color region in the area, and taken out; transmitting and receiving unit, configured to color-image extraction region is transmitted to the server cloud.
  17. 17.如权利要求12所述的系统,其特征在于: 移动终端还包括: 摄像头,用于采集整个试纸条的图像; 处理单元,用于: 筛选定位点的位置,通过定位点定位显色区域的位置和水平、垂直方向的位置, 在该区域中找出符合预先设定比例要求的区域作为显色区域,并截取出来; 发送接收单元,用于将截取的显色区域图像发送给云端服务器。 17. The system of claim 12, wherein: the mobile terminal further comprising: a camera for acquiring images of the entire test strip; a processing unit for: screening the position of the anchor point, by positioning the color point positioning position and a horizontal region, the vertical position, identify the area in line with the requirements of the preset area ratio as a color area, and taken out; transmitting and receiving unit, for displaying a color image area, taken to a cloud server.
  18. 18.如权利要求12所述的系统,其特征在于: 移动终端还包括: 触摸显示屏,用于对于第三方没有预设边框的普通试纸,在触摸显示屏上显示符合试纸大小的取景框,提示用户用取景框套住整个试纸或者显色区域,并点击拍照按钮。 18. The system of claim 12, wherein: the mobile terminal further comprising: a touch screen, a predetermined frame for a third party without the ordinary paper, on the touch screen display in line with the viewfinder of the paper size, the user is prompted to trap the entire area with paper or color viewfinder and click the camera button.
  19. 19.如权利要求12-18所述的系统,其特征在于: 所述移动终端对截取的显色区图片进行标准化处理,将图片整理成统一的像素大小,或者将拍照时空间上或平面上偏移的图片旋转回来。 19. The system according to claim 12-18, wherein: said mobile terminal taken color image area is normalized, the image pixel size organized into a unified, or when taking a plane or space offset image rotation back.
  20. 20.如权利要求12-18所述的系统,其特征在于: 云端服务器还包括处理单元,用于: 设参考区(C线)的颜色值或灰度值为β,测试区(Τ线)的颜色值或灰度值为α,则通过α与β的相关比值运算得到样本浓度比Y。 20. The system according to claim 12-18, wherein: the cloud server further comprises a processing unit, configured to: set a reference region (C line) color value or gray value beta], test zone (Τ line) a color value or gray value α, the concentration of the sample is obtained by calculating the ratio of [alpha] associated with β ratio Y.
  21. 21.如权利要求20所述的系统,其特征在于: 对于非免疫层析试纸,通过其标准颜色空白垫或者采取边缘、卡壳、外包装的图像,计算颜色值或灰度值,作为参考区颜色值或灰度值β。 21. The system according to claim 20, wherein: for non immunochromatographic test strip through which the color standard blank or take pad edge, stuck, overpack image, a color or gray value is calculated as the reference region color or gray value β.
  22. 22.如权利要求12所述的系统,特征在于: 云端服务器还包括: 数据库,用于存储每个批次试纸的标准曲线,其中标准曲线是对应每批生产的试纸产品,使用标准浓度物质对该批次产品进行定标,通过测试区(Τ线)和控制区(C线)两者颜色值或灰度值的比值运算得出样本浓度比,根据样本浓度比值与标准物质真实浓度值的对应关系,产生该批次试纸的标准曲线; 处理单元,用于: 根据库存留样的产品随时间变化的改变,更新标准曲线; 根据移动终端传输的显色图像,计算出来的样本浓度比值(C、T比值),与该批次的标准曲线进行拟合运算,得出本次检验中待检物质的真实浓度值。 22. The system of claim 12, wherein: the cloud server further comprising: a database for storing test strips for each batch of standard curve, wherein the standard curve is corresponding to each production lot of paper products, use of the standard concentration of the substance the batch is scaled by a test zone (Τ line) and the control zone (C line) calculating the ratio of both the color or gray value of the concentration ratio of the samples obtained, the sample according to the concentration ratio of the true concentration value of standard substance correspondence relation generating a standard curve of the batch of paper; a processing unit, configured to: according to the kind of product remaining inventory changes with time change, updates the standard curve; mobile terminal in accordance with the color image transfer, the calculated ratio of the concentration of the sample ( C, T ratio), the standard curve fitting operation of the batch, the true concentration values ​​obtained in this test to be the test substance.
  23. 23.—种基于移动终端摄像头的试纸读取与分析系统,用于计算试纸中样本的浓度值并分析测试结果,其特征在于包括: 移动终端,用于采集试纸图像,分析识别显色区的边缘,截取符合要求的显色区域,发送给云端服务器; 云端服务器,用于: 根据接收的显色区图片,计算显色区图片中测试区(T线)和控制区(C线)的颜色值或灰度值,利用两者颜色值或灰度值的比值运算得出样本浓度比; 对样本浓度比进行批次校准,将样本浓度比值代入该试纸批次的标准曲线进行拟合运算,计算出该样本中待检物的真实浓度值; 判断该检测项目是否需要进行再次检测; 如果无需再次检测,则将计算出的样本中待检物的真实浓度值与数据库中的数值范围进行比较,找出该浓度值对应的诊断结果以及相应的医疗建议;保存样本数值以及相应的医诊断结果,向用户返回检 23.- kinds of paper based on the mobile terminal reads the camera and analysis system, the sample strip is calculated density value for the analysis and test results, characterized by comprising: a mobile terminal for image capture strip, identified color region edge, taken in line with the requirements of the coloring region, is sent to the cloud server; cloud server configured to: according to the received color image regions, calculating image region in the color development test region (T line) and the control zone (C line) or gray value by calculating the ratio of both the color or gray value of concentration ratio obtained sample; sample batch calibration concentration ratio, the concentration ratio is substituted into the sample standard curve were fitted to the test strip batch operation, calculate the true concentration of the analyte in the sample; and determining whether the test items need to be detected again; if necessary to detect again, the true concentration value range of the database will be calculated analyte in the sample is compared to find values ​​corresponding to the concentration of the diagnosis result and the corresponding medical advice; stored sample values ​​and the corresponding medical diagnosis, the subject returned to the user 结果、对应的诊断结论以及建议; 如果需要进行多次检测,则保存本次样本真实浓度值,向用户发送检测样本结果以及下次检测时间;定时器设定下一次检测的时间,并在定时器到达时向用户的移动终端发送提示消息,接收下一次检测的显色区图片。 As a result, the corresponding diagnostic conclusions and recommendations; detected several times if necessary, save the current sample real density value, and transmits the detection result of the next sample detection time to a user; set timer time detection time, and the timing when the transmission reaches the user's mobile terminal prompt message, detecting a reception of a color image area.
  24. 24.—种基于移动终端摄像头和云端服务器的试纸读取与分析系统,用于计算试纸中样本的浓度值并分析测试结果,其特征在于包括: 移动终端,用于采集试纸图像,发送给云端服务器; 云端服务器,用于: 接收试纸图片,分析识别显色区的边缘,截取符合要求的显色区域; 计算显色区中测试区(T线)和控制区(C线)的颜色值或灰度值,利用两者颜色值或灰度值的比值运算计算得出样本浓度比; 对样本浓度比进行批次校准,将样本浓度比值带入该试纸批次的标准曲线进行拟合运算,计算出该样本中待检物的真实浓度值; 根据样本真实浓度值查找匹配的检测结果,并将检测结果发送给移动终端。 24.- species strip analysis system reads the camera and the mobile terminal based on a cloud server, used to calculate the concentration of the sample strip and analyze the test results, comprising: a mobile terminal, for acquiring image strip, it is sent to the cloud server; cloud server for: receiving image strips, the edge analysis identified the color area, the interception of the region in line with the required color; color color region value calculation test region (T line) and the control zone (C line), or tone value, the ratio calculation using both the color or gray value of concentration ratio calculated sample; sample batch calibration concentration ratio, the ratio of the concentration of the sample into the test strip batch standard curve fitting operation is performed, calculate the true concentration of the analyte in the sample; find the matching value according to the detection result of the true concentration sample, and the detection result to the mobile terminal.
  25. 25.一种用于试纸读取与分析的移动终端,其特征在于包括: 摄像头,用于获取试纸的识别码和图像; 触摸显示屏,用于显示获取的图像内容,提示用户对准试纸的正确位置; 处理单元,用于分析识别显色区的边缘,截取符合要求的显色区域; 发送接收单元,用于向云端服务器发送识别码和显色区图片并接收云端服务器返回的检测结果。 25. A mobile terminal for reading and analysis of the test strips, comprising: a camera for acquiring the image and the identification code of the test strips; touch screen, for displaying the acquired image content, prompting the user to align the test paper the correct position; a processing unit for an edge region analysis identifies the color, the color taken to meet the requirements of the region; transmitting and receiving means for transmitting an identification code and a color image area and the cloud server receives the detection result returned by the first server.
  26. 26.如权利要求25所述的移动终端,其特征在于: 所述处理单元用于颜色和边缘分析识别,通过预先设定试纸的卡壳与显色区域的色差,找到预先设定的边框,选定该区域; 在该区域中找出符合预先设定比例要求的区域作为显色区域,并截取出来。 26. The mobile terminal according to claim 25, wherein: said processing means for color identification and analysis edge, with the card housing through a predetermined color of the coloring region of the strip, is set in advance to find the border, selected from given this region; to identify the predetermined region in line with the proportion required in the area as a color area, and taken out.
  27. 27.如权利要求25所述的移动终端,其特征在于: 所述处理单元用于筛选定位点的位置,通过定位点定位显色区域的位置和水平、垂直方向的位置; 在该区域中找出符合预先设定比例要求的区域作为显色区域,并截取出来。 27. The mobile terminal according to claim 25, wherein: said processing means for screening the position of the anchor point, and a position substantially horizontal color area, the vertical direction is positioned by the positioning point; in this area to find meet the requirements of the preset area ratio as a color area, and taken out.
  28. 28.如权利要求25所述的移动终端,其特征在于: 所述触摸显示屏用于对于第三方没有预设边框的普通试纸,在触摸显示屏上显示符合试纸大小的取景框,提示用户用取景框套住整个试纸或者显色区域,并点击拍照按钮。 28. The mobile terminal according to claim 25, wherein: the touch screen is used for ordinary paper is not preset to third border, on the touch screen display in line with the viewfinder paper size, the user is prompted with viewfinder trap the entire paper or color area, and click the camera button.
  29. 29.如权利要求25-28所述的移动终端,其特征在于: 所述处理单元对截取的显色区图片进行标准化处理,将图片整理成统一的像素大小,或者将拍照时空间上或平面上偏移的图片旋转回来。 29. The mobile terminal according to claim 25-28, wherein: the processing unit of the taken color image is normalized areas, organized into a unified picture of the pixel size, or the space or plane when photographing the offset image rotation back.
  30. 30.一种用于移动终端中的试纸读取与分析的方法,其特征在于包括以下步骤: 摄像头获取试纸的识别码和图像; 触摸显示屏显示获取的图像内容,提示用户对准试纸的正确位置; 分析识别显色区的边缘,截取符合要求的显色区域; 向云端服务器发送识别码和显色区图片并接收云端服务器返回的检测结果。 30. A method of reading and analysis of test paper is used for a mobile terminal, comprising the steps of: obtaining an identification code and the camera image of the test strips; touch screen display image acquired content, the user prompts the correct alignment of the test strip position; edge analysis identified the color region, the color taken to meet the requirements of the region; and sending the identification code to a color image area and the cloud server receives the detection result returned by the first server.
  31. 31.如权利要求30所述的方法,其特征在于: 所述分析识别显色区的边缘,截取符合要求的显色区域的步骤进一步包括: 颜色和边缘分析识别,通过预先设定试纸的卡壳与显色区域的色差,找到预先设定的边框,选定该区域; 在该区域中找出符合预先设定比例要求的区域作为显色区域,并截取出来。 31. A method according to claim 30, wherein: the color analysis identified the edge region, the step of the coloring region in line with the requirements taken further comprising: edge analysis and color recognition, by setting in advance the paper jam the color of the coloring region to find predetermined frame, the selected region; identify a preset area ratio meet the requirements as a color area, and taken out in this region.
  32. 32.如权利要求30所述的方法,其特征在于: 所述分析识别显色区的边缘,截取符合要求的显色区域的步骤进一步包括: 筛选定位点的位置,通过定位点定位显色区域的位置和水平、垂直方向的位置; 在该区域中找出符合预先设定比例要求的区域作为显色区域,并截取出来。 32. The method according to claim 30, wherein: the color analysis identified the edge region, the step taken in line with the requirements of the coloring region further comprising: screening anchor point position, by the positioning point positioning coloring region and a position horizontal, vertical; identify a preset area ratio meet the requirements as a color area, and taken out in this region.
  33. 33.如权利要求30所述的方法,其特征在于: 所述分析识别显色区的边缘,截取符合要求的显色区域的步骤进一步包括: 对于第三方没有预设边框的普通试纸,在触摸显示屏上显示符合试纸大小的取景框,提示用户用取景框套住整个试纸或者显色区域,并点击拍照按钮。 33. The method according to claim 30, wherein: the color analysis identified the edge region, the step of coloring region claim further comprising intercepting meet: No third-party predetermined frame of ordinary paper, in the touch the display shows the size of the paper in line with the viewfinder, the user is prompted to trap the entire area with paper or color viewfinder and click the camera button.
  34. 34.如权利要求30-33所述的移动终端,其特征在于: 所述分析识别显色区的边缘,截取符合要求的显色区域的步骤进一步包括: 对截取的显色区图片进行标准化处理,将图片整理成统一的像素大小,或者将拍照时空间上或平面上偏移的图片旋转回来。 34. The mobile terminal according to claim 30-33, wherein: an edge of the color analysis identified regions, a step taken in line with the coloring region claim further comprising: intercepting color image area is normalized will be organized into a unified picture when the pixel size, or to take pictures of the offset space on the plane or rotate the picture back.
  35. 35.一种用于试纸读取与分析的云端服务器,其特征在于包括: 发送接收模块,用于接收试纸显色区图片,并向移动终端发送检测结果; 数据库,用于存储各个检测项目不同批次的标准曲线,所述标准曲线用于表示测量值与真实浓度值的对应关系,并存储不同检测项目的真实浓度值对应的诊断结果与医疗建议; 处理单元,用于: 分析显色区图片,计算显色区图片中的测试区(T线)和控制区(C线)的颜色值或灰度值,利用两者颜色值或灰度值的比值运算得出样本浓度比; 对样本浓度比进行批次校准,将样本浓度比值带入该试纸批次的标准曲线进行拟合运算,计算出该样本中待检物的真实浓度值; 根据样本中待检物的真实浓度值查找匹配的检测结果。 35. A method of reading and analyzing the paper for cloud server, comprising: transmitting and receiving means for receiving image strips color area, to the mobile terminal sends a detection result; different database for storing respective detection items batches of the standard curve, said standard curve representing a correspondence relationship between the measured value and the true density value, and stores the density value corresponding to the true diagnosis and medical advice of different test items; a processing unit for: analyzing the color region pictures, the test zone (T) for calculating the color image region and the control region (C line) the color or gray value by calculating the ratio of both the color or gray value of concentration ratio obtained sample; sample batch calibration concentration ratio, the ratio of the concentration of the sample into the test strip batch standard curve fitting calculation to calculate the true concentration of the analyte in the sample; find a match based on the true concentration of analyte in the sample test results.
  36. 36.如权利要求35所述的云端服务器,其特征在于: 所述处理单元还用于: 设参考区(C线)的颜色值或灰度值为β,测试区(Τ线)的颜色值或灰度值为α,则通过α与β的相关比值运算得到样本浓度比Y。 36. The cloud server according to claim 35, wherein: the processing unit is further configured to: set a reference region (C line) color value or gray value beta], test zone (Τ line) color value or gray value α, than the concentration of the sample is obtained by a correlation ratio Y. [alpha] and β of calculation
  37. 37.如权利要求35所述的云端服务器,其特征在于: 所述处理单元还用于: 对于非免疫层析试纸,通过其标准颜色空白垫或者采取边缘、卡壳、外包装的图像,计算颜色值或灰度值,作为参考区颜色值或灰度值β。 37. The cloud server according to claim 35, wherein: the processing unit is further configured to: for non immunochromatographic test strip, gaps through which pad edges or take a standard color, stuck, overpack image, calculating the color or gray value, color value as the reference regions or the gray value β.
  38. 38.如权利要求35所述的云端服务器,其特征在于: 所述数据库存储的标准曲线,是对应每批生产的试纸产品,使用标准浓度物质对该批次产品进行定标,通过测试区(Τ线)和控制区(C线)两者颜色值或灰度值的比值运算得出样本浓度比,根据样本浓度比值与标准物质真实浓度值的对应关系,产生该批次试纸的标准曲线。 38. The cloud server according to claim 35, wherein: said calibration curve stored in the database, the corresponding batch production of paper products, the concentration of the substance using the standard batch is scaled by a test zone ( Τ line) and the control zone (C line) calculating the ratio of both the color or gray value derived sample concentration ratio, based on the correspondence relationship between the concentration ratio of the true concentration of the standard substance samples, generating a standard curve of the batch of paper.
  39. 39.如权利要求38所述的云端服务器,其特征在于: 所述处理单元,根据库存留样的产品随时间变化的改变,更新标准曲线。 39. The cloud server according to claim 38, wherein: said processing unit, according to the inventory of the product leaving the sample changes over time, updates the standard curve.
  40. 40.一种用于云端服务器中的试纸读取与分析方法,其特征在于包括: 接收试纸显色区图片,并向移动终端发送检测结果; 存储各个检测项目不同批次的标准曲线,所述标准曲线用于表示测量值与真实浓度值的对应关系,并存储不同检测项目的真实浓度值对应的诊断结果与医疗建议; 计算显色区图片中的测试区(Τ线)和控制区(C线)的颜色值或灰度值,利用两者颜色值或灰度值的比值运算得出样本浓度比; 对样本浓度比进行批次校准,将样本浓度比值带入该试纸批次的标准曲线进行拟合运算,计算出该样本中待检物的真实浓度值; 根据样本中待检物的真实浓度值查找匹配的检测结果。 40. A dipstick reading and analysis methods used in the first server, comprising: receiving test strips color image area, and transmits the detection result of the mobile terminal; different batches of the respective detection items stored in the standard curve, the a standard curve representing a correspondence relationship between the measured value and the true density value, and stores the density value corresponding to the true diagnosis and medical advice of different test items; calculating a test zone (Τ line) in the color image region and the control region (C line) the color or gray value by calculating the ratio of both the color or gray value of concentration ratio obtained sample; sample batch calibration concentration ratio, the ratio of the concentration of the sample into a standard curve the strip batch fitting calculation to calculate the true concentration of the analyte in the sample; find matching detection result based on the true concentration of analyte in the sample.
  41. 41.如权利要求40所述的方法,其特征在于: 所述计算样本含量的步骤进一步包括: 设参考区(C线)的颜色值或灰度值为β,测试区(Τ线)的颜色值或灰度值为α,则通过α与β的相关比值运算得到样本浓度比Y。 41. The method according to claim 40, wherein: the sample size calculation step further comprises: setting a reference color or gray region (C line) is beta], the color of the test area (Τ line) value or gray value α, than the concentration of the sample is obtained by a correlation ratio Y. [alpha] and β of calculation
  42. 42.如权利要求41所述的方法,其特征在于: 所述计算样本含量的步骤进一步包括: 对于非免疫层析试纸,通过其标准颜色空白垫或者采取边缘、卡壳、外包装的图像,计算颜色值或灰度值,作为参考区颜色值或灰度值β。 42. The method according to claim 41, wherein: the sample size calculation step further comprises: for a non immunochromatographic test strip, a standard white color or pad taken through its edge, jam, packaging images calculated color or gray value, as the color or gray reference area value β.
  43. 43.如权利要求40所述的方法,其特征在于: 所述批次校准的步骤进一步包括:对应每批生产的试纸产品,使用标准浓度物质对该批次产品进行定标,通过测试区(Τ线)和控制区(C线)两者颜色值或灰度值的比值运算得出样本浓度比,根据样本浓度比值与标准物质真实浓度值的对应关系,产生该批次试纸的标准曲线。 43. The method according to claim 40, wherein: said step of calibrating further comprises the batch: batch to batch corresponding to paper products, the concentration of the substance using the standard batch is scaled by a test zone ( Τ line) and the control zone (C line) calculating the ratio of both the color or gray value derived sample concentration ratio, based on the correspondence relationship between the concentration ratio of the true concentration of the standard substance samples, generating a standard curve of the batch of paper.
  44. 44.如权利要求43所述的云端服务器,其特征在于: 所述批次校准的步骤进一步包括:根据库存留样的产品随时间变化的改变,更新标准曲线。 44. The cloud server according to claim 43, wherein: the step of calibrating said batch further comprising: the left kind of product inventory changes with time change, updates the standard curve.
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