CN108323757A - A kind of composite chewable tablet with anti-oxidation efficacy - Google Patents
A kind of composite chewable tablet with anti-oxidation efficacy Download PDFInfo
- Publication number
- CN108323757A CN108323757A CN201810069243.9A CN201810069243A CN108323757A CN 108323757 A CN108323757 A CN 108323757A CN 201810069243 A CN201810069243 A CN 201810069243A CN 108323757 A CN108323757 A CN 108323757A
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- CN
- China
- Prior art keywords
- fruit powder
- raspberry
- parts
- chinese wolfberry
- chewable tablet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
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Abstract
The present invention provides a kind of composite chewable tablet with anti-oxidation efficacy, it be include that the supplementary material of following weight proportion is prepared：Raw material：5~20 parts of raspberry fruit powder, 5~20 parts of seabuckthorn fruit powder, 5~20 parts of Chinese wolfberry fruit powder；Right amount of auxiliary materials：Include the combination of one or more of microcrystalline cellulose, starch, Macrogol 6000, glucose, magnesium stearate.The present invention also provides the purposes of the fruit powder composite chewable tablet.The present invention, can notable scavenging hydroxyl, ultra-oxygen anion free radical and ABTS free radicals the study found that three kinds of raspberry, sea-buckthorn and matrimony vine fruit powders all have good anti-oxidation function.But raspberry, sea-buckthorn, three seed pod compound powder of matrimony vine show better antioxidant activity compared with independent fruit powder.The composite chewable tablet with anti-oxidation efficacy that the present invention obtains is with nutritive value higher, many advantages, such as bioactivity is more preferable, and mouthfeel is good, easy to carry, and target user is extensive.
Description
Technical field
The invention belongs to field of health care products, and in particular to a kind of composite chewable tablet with anti-oxidation efficacy and its answer
With.
Technical background
Free radical refers to that those are free existing, molecule, ion, atom containing 1 or 1 or more unpaired electronics or
Atomic group, they are the products of body eubolism, there is very strong oxidation reaction ability in vivo.Under normal circumstances, body
Oxidative and anti-oxidative is in a kind of dynamic equilibrium.Under equilibrium state, eubolism product of the free radical as body, be body not
The active material that can lack.Once balance is broken, free radical will generate powerful injury effect, cause the lipid of biomembrane
Peroxide injury, the Oxidative demage for causing enzyme, amino acid, protein generate shadow to the morphological function of internal organs, immune system
It rings, disease caused by being increased due to Free Radical Level so as to cause atherosclerosis, tumour, parkinson's syndrome etc. are a variety of
Disease.With the quickening of modern life rhythm, the aggravation of social competition, the tired long-term accumulation such as physical, mental, psychological of people,
The factors such as diet is unhealthy in addition, environmental radiation increases cause people's interior free yl excessive, and more and more people is made to be in " sub-
Health " state.Therefore, superfluous free radical is removed for maintaining body health, prevention of various diseases to have particularly important meaning
Justice.
Raspberry (Rubus corchoriflius) is rose family rubus plant also known as raspberry, raspberry, thorn
Bubble etc., is distributed widely in Northern Hemisphere temperate zone and frigid zone.Fruit of raspberry is sweet slightly sour, full of nutrition, has high nutritive value
And health-care efficacy, it is known as " king of fruit " and " life fruit ".Fruit of raspberry containing the indispensable nutrient of a variety of human bodies,
Such as vitamin B2, vitamin A, vitamin C, vitamin E, calcium, iron, zinc, magnesium, potassium, wherein ascorbic content is far above general
Water flowing fruit.Fruit of raspberry is rich in 21 kinds of amino acid being easily absorbed by the body, and is especially enriched in a variety of essential amino acids.In addition,
Raspberry also contains polysaccharide, organic acid, flavones, anthocyanidin, the various actives such as polyphenol, vitamin, mineral element, volatile oil, tannin
Ingredient has the extensive pharmacological actions such as anti-oxidant, antibacterial, suppression cancer, hypoglycemic, cardiovascular protection.
Sea-buckthorn (Hippophae rhamnoides) is Elaeangnaceae hippophae plant, also known as sour thorn, vinegar willow, black thorn,
China is northern and the multiple provinces and regions in southwest have widely distributed, resistance is strong, and the ecological value is high.Sea buckthorn fruit is sour-sweet, and nutrition is rich
Richness, health value are very big.Contain abundant vitamin in sea buckthorn fruit, it includes vitamin C, dimension life to be known as " vitamin treasure-house "
Plain E, vitamin B1, vitamin B6, vitamin K, carrotene, folic acid, vitamin D, niacin etc..There are many containing in sea-buckthorn pulp
The unsaturated fatty acid being easily absorbed by the body.Flavonoids, phenols, organic acid, terpene and steroid there are many also containing in sea buckthorn fruit
There is lowering blood pressure and blood fat, anti-oxidant, liver protection, enhancing to be immunized, prevent and control for body class compound, carbohydrate, volatile ingredient etc.
The extensive pharmacological actions such as cardiovascular and cerebrovascular disease are treated, are the medical and edible dual purpose plant resources of preciousness.
Matrimony vine (Lycium barbarum) is Solanaceae Lycium shrub also known as the fruit of Chinese wolfberry, matrimony vine etc..Matrimony vine is rare
Medicinal material and invigorant have extensive pharmacological activity and high health value.Medlar total saccharide amount is 46.5%, wherein main living
Property ingredient polysaccharides content is 5.42%~8.23%.Matrimony vine contains 19 kinds of amino acid (including 8 kinds of essential amino acids), always
Amount is 9.14%.The trace elements such as the big zinc of matrimony vine also amount, iron, copper, germanium, copper, manganese, magnesium, calcium, potassium, iron, vitamin C, Hu Luo
The vitamins such as Bu Su, B family vitamin, vitamin E, vitamin D, thiamine, riboflavin, niacin, niacinamide.In addition, in matrimony vine also
There are alkaloid, aliphatic acid, volatile ingredient, inorganic salts etc..Modern pharmacology research shows that matrimony vine has and adjusts immune, antioxygen
A variety of pharmacological activity such as change, anti-aging, hypoglycemic, reducing blood lipid, antitumor, anti-mutagenesis, radiation protection.
In recent years, the continuous improvement of the gradual intensification and health care consciousness that berry are recognized with people, raspberry, sea-buckthorn, Chinese holly
The berry full of nutrition such as Qi increasingly receives an acclaim.Therefore, break berry tradition edible way, intensive processing is carried out, to reality
The higher value application of existing berry has very important significance.Raspberry, sea-buckthorn, Chinese wolfberry fruit powder are prepared into Composite Chew by the present invention
Piece obtains better antioxidant activity on the basis of farthest retaining three kinds of berry nutritional ingredients, has extremely wide
Wealthy market prospects.
Invention content
The purpose of the present invention is to provide a kind of based on the composite chewable tablet with anti-oxidation efficacy.Another mesh of the present invention
Be the purposes of the fruit powder composite chewable tablet is provided.
Specifically, the present invention provides a kind of composite chewable tablet with anti-oxidation efficacy, it be include that following weight is matched
The supplementary material of ratio is prepared：
Raw material：5~20 parts of raspberry fruit powder, 5~20 parts of seabuckthorn fruit powder, 5~20 parts of Chinese wolfberry fruit powder；
Right amount of auxiliary materials：Including one kind or two in microcrystalline cellulose, starch, Macrogol 6000, glucose, magnesium stearate
Kind or more combination.
Further, raspberry fruit powder:Seabuckthorn fruit powder:Chinese wolfberry fruit powder=1:1:1.
Further, the weight proportion of the auxiliary material is：10~20 parts of microcrystalline cellulose, 15~40 parts of starch, poly- second two
6,000 1~5 parts of alcohol, 5~15 parts of glucose, 0.5~2 part of magnesium stearate.
Further, the weight proportion of the auxiliary material is：12~20 parts of microcrystalline cellulose, 18~35 parts of starch, poly- second
6,000 4 parts of glycol, 5~10 parts of glucose, 1 part of magnesium stearate.
Wherein, the raspberry fruit powder, seabuckthorn fruit powder, Chinese wolfberry fruit powder are to be prepared one of by the following method：
Method one：Raspberry, sea-buckthorn, Chinese wolfberry fruit is taken to be crushed to 600~800 mesh after dry, respectively obtain raspberry respectively
Fruit powder, seabuckthorn fruit powder, Chinese wolfberry fruit powder；
Method two：Raspberry, sea-buckthorn, Chinese wolfberry fruit are taken respectively, is squeezed the juice, is filtered, and after fruit juice spray drying, respectively obtain raspberry
Fruit powder, seabuckthorn fruit powder, Chinese wolfberry fruit powder；
Method three：Raspberry, sea-buckthorn, Chinese wolfberry fruit are taken respectively, are extracted by solvent of water, after extracting solution spray drying,
Respectively obtain raspberry fruit powder, seabuckthorn fruit powder, Chinese wolfberry fruit powder.
The present invention also provides raspberry, sea-buckthorn, Chinese wolfberry fruit powder composition or above-mentioned composite chewable tablets to prepare anti-oxidant work(
Imitate the purposes in food, health products or drug.
Further, the food, health products or drug be scavenging hydroxyl, ultra-oxygen anion free radical or ABTS from
By the food, health products or drug of base.
Preferably, the food, health products or drug be the food for removing ultra-oxygen anion free radical or ABTS free radicals,
Health products or drug.
The present invention can be shown the study found that raspberry fruit powder, seabuckthorn fruit powder, Chinese wolfberry fruit powder all have good anti-oxidation function
Write scavenging hydroxyl, ultra-oxygen anion free radical and ABTS free radicals.
The present invention also found in an experiment, raspberry, sea-buckthorn, Chinese wolfberry fruit powder composition antioxidant activity be substantially better than equally
The individual antioxidant activity of the lower three kinds of fruit powders of concentration (especially ultra-oxygen anion free radical or ABTS free radicals).Above-mentioned experiment knot
By sufficing to show that, raspberry provided by the invention, sea-buckthorn, Chinese wolfberry fruit powder composition have the function of synergy.
In addition, raspberry, sea-buckthorn, Chinese wolfberry fruit powder are prepared into composite chewable tablet by the present invention, farthest retain raspberry,
Sea-buckthorn, three kinds of fruit powders of matrimony vine nutritional ingredient while, be more advantageous to storage, the transportation and packaging of product, and be suitble to all kinds of people
The use of group.
Description of the drawings
Fig. 1 raspberries, sea-buckthorn, Chinese wolfberry fruit powder combine the Scavenging activity to ABTS with three kinds of fruit powders
Fig. 2 raspberries, sea-buckthorn, Chinese wolfberry fruit powder are combined with three kinds of fruit powders to ultra-oxygen anion free radical Scavenging activity
Fig. 3 raspberries, sea-buckthorn, Chinese wolfberry fruit powder combine the Scavenging activity to hydroxy radical with three kinds of fruit powders
Specific implementation mode
The preparation of the three kinds of fruit powders of the invention of embodiment 1
Raspberry, sea-buckthorn, Chinese wolfberry fruit is taken to be crushed to 600~800 mesh after dry to get raspberry fruit powder, fructus hippophae respectively
Powder and Chinese wolfberry fruit powder.
The preparation of 2 chewable tablets of the present invention of embodiment
Table 1
Antioxidation activity in vitro is tested
(1) material：Raspberry fruit powder, seabuckthorn fruit powder, Chinese wolfberry fruit powder and three seed pod compound powders are (with reference to the embodiment of the present invention
1 group of 1 preparation).
(2) laboratory apparatus and reagent：Tube centrifuge (TGL-16G-A types, Anting Scientific Instrument Factory, Shanghai)；It can be seen that ultraviolet
Spectrophotometer (UV-722N, Shanghai Ni Ke Co., Ltds)；Thermostat water bath (HD types, Constant Temp. Instrument Factory, Liaoyang).ABTS is purchased
In Shanghai Jing Chun biochemical technologies limited liability company (Aladdin)；Potassium peroxydisulfate, sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium chloride,
The reagents such as trichloroacetic acid are purchased from Shandong YuWang Industry Co., Ltd；Superoxide anion kit, hydroxy radical kit are purchased
Bio tech ltd is built up in Nanjing.
(3) ABTS Scavenging activities：ABTS is dissolved into (+H2O) to final concentration of 7mmol/L, potassium peroxydisulfate is configured to
2.45mmol/L mixes the two solution, is positioned over dark, stirs 16h under room temperature；Then ABTS mixed solutions are used
It is 0.70 ± 0.02 that PBS solution (PH=7.0), which is diluted to its light absorption value (being surveyed at 734nm),；Raspberry, sea-buckthorn, three seed pod of matrimony vine
Powder and three seed pod compound powders respectively with distilled water be diluted to various concentration (0.5mg/mL, 1mg/mL, 2mg/mL, 4mg/mL,
8mg/mL and 16mg/mL)；Finally the sample of above-mentioned various concentration is added in ABTS mixed solutions, sample is mixed with ABTS
It is 1 to close solution proportion:20,6min is incubated after mixing at room temperature, light absorption value is measured at 734nm.It is calculated clearly according to formula
Except rate.ABTS clearance rates (%)=(1- samples light absorption value/blank absorbency) × 100%.The result is shown in Figure 1
(4) ultra-oxygen anion free radical Scavenging activity：It is free that superoxide anion is generated using xanthine/xanthine oxidase
Scavenging activity of the base system of determination to superoxide radical.Raspberry, sea-buckthorn, three kinds of fruit powders of matrimony vine and three seed pod compound powders are distinguished
It is diluted to various concentration (1mg/mL, 2mg/mL, 4mg/mL, 8mg/mL, 16mg/mL) with distilled water.Each group sequentially adds
75mmol/L phosphate buffers (pH7.8) 1ml, sample 0.2ml (control group is replaced with distilled water), 0.1mol/L hydroxylamine hydrochlorides
Solution 0.1ml, 75mmol/L xanthine solution 0.1ml and 0.037U/ml xanthine oxidase solution 0.1ml, after mixing
27 DEG C of incubation 30min.2ml color developing agents (0.4g/L alpha naphthylamine+4g/L p-aminobenzene sulfonic acid) are added, 5min is stood after mixing,
Light absorption value on the downside of 530nm.Clearance rate is calculated according to formula.Ultra-oxygen anion free radical clearance rate (%)=1- sample extinctions
Value/blank absorbency × 100%.As a result see Fig. 2
(5) Hydroxyl radical-scavenging ability：Hydroxy radical is generated using Fenton reaction principles, is sent with sarranine developing dye
Measure the Scavenging activity to hydroxy radical.Raspberry, sea-buckthorn, three kinds of fruit powders of matrimony vine and three seed pod compound powders are used into distilled water respectively
It is diluted to various concentration (1mg/mL, 2mg/mL, 4mg/mL, 8mg/mL, 16mg/mL).Each group sequentially adds 0.15mol/L's
The EDTANa- of Tris-HCl buffer solutions (pH7.4) 1ml, 0.04mg/ml sarranine solution 1ml, distilled water 1ml, 0.945mmol/L
Fe2+Solution (pH7.4) 0.5ml, sample 0.5ml and 1%H2O2Solution 0.5ml is incubated 30min, control group distillation in 37 DEG C
Water replaces, blank group EDTANa-Fe2+Solution and sample are replaced with distilled water.Light absorption value is detected at 520nm.According to formula meter
Calculate clearance rate.Scavenging action to hydroxyl free radical (%)=1- samples light absorption value/blank absorbency × 100%.As a result see Fig. 3.
Claims (8)
1. a kind of composite chewable tablet with anti-oxidation efficacy, it is characterised in that：It is the supplementary material for including following weight proportion
It is prepared：
Raw material：5~20 parts of raspberry fruit powder, 5~20 parts of seabuckthorn fruit powder, 5~20 parts of Chinese wolfberry fruit powder；
Right amount of auxiliary materials：Including one or both of microcrystalline cellulose, starch, Macrogol 6000, glucose, magnesium stearate with
On combination.
2. the composite chewable tablet according to claim 1 with anti-oxidation efficacy, it is characterised in that：Raspberry fruit powder:Sea-buckthorn
Fruit powder:Chinese wolfberry fruit powder=1:1:1.
3. the composite chewable tablet according to claim 1 with anti-oxidation efficacy, it is characterised in that：The weight of the auxiliary material
Proportioning is：10~20 parts of microcrystalline cellulose, 15~40 parts of starch, 1~5 part of Macrogol 6000,5~15 parts of glucose are stearic
0.5~2 part of sour magnesium.
4. the composite chewable tablet according to claim 3 with anti-oxidation efficacy, it is characterised in that：The weight of the auxiliary material
Proportioning is：12~20 parts of microcrystalline cellulose, 18~35 parts of starch, 4 parts of Macrogol 6000,5~10 parts of glucose, stearic acid
1 part of magnesium.
5. the composite chewable tablet according to claim 1 or 2 with anti-oxidation efficacy, it is characterised in that：The raspberry fruit
Powder, seabuckthorn fruit powder, Chinese wolfberry fruit powder are to be prepared one of by the following method：
Method one：Take raspberry, sea-buckthorn, Chinese wolfberry fruit respectively, after dry, be crushed to 600~800 mesh, respectively obtain raspberry fruit powder,
Seabuckthorn fruit powder, Chinese wolfberry fruit powder；
Method two：Raspberry, sea-buckthorn, Chinese wolfberry fruit are taken respectively, is squeezed the juice, is filtered, and after fruit juice spray drying, respectively obtain raspberry fruit
Powder, seabuckthorn fruit powder, Chinese wolfberry fruit powder；
Method three：Raspberry, sea-buckthorn, Chinese wolfberry fruit are taken respectively, is extracted by solvent of water, after extracting solution spray drying, respectively
Obtain raspberry fruit powder, seabuckthorn fruit powder, Chinese wolfberry fruit powder.
6. the composite chewable tablet with anti-oxidation efficacy described in Claims 1 to 5 is preparing the food for having anti-oxidation efficacy, is protecting
Purposes in strong product or drug.
7. purposes according to claim 6, it is characterised in that：The food, health products or drug be scavenging hydroxyl,
The food of ultra-oxygen anion free radical or ABTS free radicals, health products or drug.
8. purposes according to claim 7, it is characterised in that：The drug, health products or functional food are to remove ABTS
The drug of free radical or ultra-oxygen anion free radical, health products or functional food.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115251221A (en) * | 2022-08-02 | 2022-11-01 | 青海大学 | Chewable raspberry tablet and preparation method thereof |
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| CN101450151A (en) * | 2007-11-30 | 2009-06-10 | 北京因科瑞斯医药科技有限公司 | Medicine composition with anti-oxidation and senescence prevention function and preparation method thereof |
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| CN105558926A (en) * | 2015-12-18 | 2016-05-11 | 中国科学院西北高原生物研究所 | Plateau berry fruit powder composition and tablet and use thereof |
| CN105767966A (en) * | 2016-03-15 | 2016-07-20 | 杨建玉 | Plant recipe feature beautifying health-care product |
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| CN115251221A (en) * | 2022-08-02 | 2022-11-01 | 青海大学 | Chewable raspberry tablet and preparation method thereof |
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