CN108185342A - A kind of composition containing seabuckthorn fruit powder and application thereof - Google Patents
A kind of composition containing seabuckthorn fruit powder and application thereof Download PDFInfo
- Publication number
- CN108185342A CN108185342A CN201810069224.6A CN201810069224A CN108185342A CN 108185342 A CN108185342 A CN 108185342A CN 201810069224 A CN201810069224 A CN 201810069224A CN 108185342 A CN108185342 A CN 108185342A
- Authority
- CN
- China
- Prior art keywords
- fruit powder
- raspberry
- chinese wolfberry
- buckthorn
- sea
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 235000011132 calcium sulphate Nutrition 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000007910 chewable tablet Substances 0.000 description 1
- 238000005660 chlorination reaction Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 229940099112 cornstarch Drugs 0.000 description 1
- 150000001896 cresols Chemical class 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 229910052732 germanium Inorganic materials 0.000 description 1
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
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- 238000000338 in vitro Methods 0.000 description 1
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- 239000008101 lactose Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 239000002366 mineral element Substances 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 230000008802 morphological function Effects 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
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- 239000011570 nicotinamide Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- 230000001603 reducing effect Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 229940079827 sodium hydrogen sulfite Drugs 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 229950000244 sulfanilic acid Drugs 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/01—Instant products; Powders; Flakes; Granules
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
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- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
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- Microbiology (AREA)
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- General Health & Medical Sciences (AREA)
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- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention provides a kind of raspberry, sea-buckthorn, Chinese wolfberry fruit powder compositions, it is prepared by the supplementary material of following weight proportion：5~20 parts of raspberry fruit powder, 5~20 parts of seabuckthorn fruit powder, 5~20 parts of Chinese wolfberry fruit powder, 10~20 parts of microcrystalline cellulose, 20~35 parts of starch, 1~5 part of Macrogol 6000,5~15 parts of glucose, 0.5~2 part of magnesium stearate.The present invention also provides the purposes of the fruit powder composition.The present invention, can notable scavenging hydroxyl, ultra-oxygen anion free radical and ABTS free radicals the study found that three kinds of raspberry, sea-buckthorn and matrimony vine fruit powders are respectively provided with good anti-oxidation function.But three kinds of raspberry, sea-buckthorn, matrimony vine berry fruit powder compositions show better antioxidant activity compared with independent fruit powder.
Description
Technical field
The invention belongs to field of health care products, and in particular to a kind of raspberry, sea-buckthorn, Chinese wolfberry fruit powder composition and its application.
Technical background
Free radical refers to that those are free existing, molecule, ion, atom containing 1 or 1 or more unpaired electronics or
Atomic group, they are the products of body eubolism, there is very strong oxidation reaction ability in vivo.Under normal circumstances, body
Oxidative and anti-oxidative is in a kind of dynamic equilibrium.Under equilibrium state, eubolism product of the free radical as body, be body not
The active material that can lack.Once balance is broken, free radical will generate powerful injury effect, cause the lipid of biomembrane
Peroxide injury, the Oxidative demage for causing enzyme, amino acid, protein generate shadow to the morphological function of internal organs, immune system
It rings, disease caused by being increased so as to cause atherosclerosis, tumour, parkinson's syndrome etc. are a variety of due to Free Radical Level
Disease.With the quickening of modern life rhythm, the aggravation of social competition, the tired long-term accumulation such as physical, mental, psychological of people,
The factors such as diet is unhealthy in addition, environmental radiation increases cause people's interior free yl excessive, and more and more people is made to be in " sub-
Health " state.Therefore, superfluous free radical is removed for maintaining body health, and prevention of various diseases has particularly important meaning
Justice.
Raspberry (Rubus corchoriflius) is rose family rubus plant also known as raspberry, raspberry, thorn
Bubble etc., is distributed widely in Northern Hemisphere temperate zone and frigid zone.Fruit of raspberry is sweet slightly sour, full of nutrition, has high nutritive value
And health-care efficacy, it is known as " king of fruit " and " life fruit ".Fruit of raspberry containing the indispensable nutrient of a variety of human bodies,
Such as vitamin B2, vitamin A, vitamin C, vitamin E, calcium, iron, zinc, magnesium, potassium, wherein ascorbic content is far above general
Water flowing fruit.Fruit of raspberry is rich in 21 kinds of amino acid being easily absorbed by the body, and is especially enriched in a variety of essential amino acids.In addition,
Raspberry is also containing polysaccharide, organic acid, flavones, anthocyanidin, the various actives such as polyphenol, vitamin, mineral element, volatile oil, tannin
Ingredient has the extensive pharmacological actions such as anti-oxidant, antibacterial, suppression cancer, hypoglycemic, cardiovascular protection.
Sea-buckthorn (Hippophae rhamnoides) is Elaeangnaceae hippophae plant, also known as sour thorn, vinegar willow, black thorn,
China is northern and the multiple provinces and regions in southwest have widely distributed, resistance is strong, and the ecological value is high.Sea buckthorn fruit is sour-sweet, and nutrition is rich
Richness, health value are very big.Containing abundant vitamin in sea buckthorn fruit, it is known as " vitamin treasure-house " and includes vitamin C, dimension life
Plain E, vitamin B1, vitamin B6, vitamin K, carrotene, folic acid, vitamin D, niacin etc..There are many containing in sea-buckthorn pulp
The unrighted acid being easily absorbed by the body.Flavonoids, phenols, organic acid, terpene and steroid there are many also containing in sea buckthorn fruit
There is lowering blood pressure and blood fat, anti-oxidant, liver protection, enhancing to be immunized, prevent and control for body class compound, carbohydrate, volatile ingredient etc.
The extensive pharmacological actions such as cardiovascular and cerebrovascular disease are treated, are precious medical and edible dual purpose plant resources.
Matrimony vine (Lycium barbarum) is Solanaceae Lycium shrub also known as the fruit of Chinese wolfberry, matrimony vine etc..Matrimony vine is rare
Medicinal material and invigorant have extensive pharmacological activity and high health value.Medlar total saccharide amount is 46.5%, wherein main living
Property ingredient polysaccharides content is 5.42%~8.23%.Matrimony vine contains 19 kinds of amino acid (including 8 kinds of essential amino acids), always
Measure is 9.14%.The trace elements such as the big zinc of matrimony vine also amount, iron, copper, germanium, copper, manganese, magnesium, calcium, potassium, iron, vitamin C, Hu Luo
The vitamins such as Bu Su, B family vitamin, vitamin E, vitamin D, thiamine, riboflavin, niacin, niacinamide.In addition, in matrimony vine also
There are alkaloid, aliphatic acid, volatile ingredient, inorganic salts etc..Modern pharmacology research shows that matrimony vine has and adjusts immune, antioxygen
A variety of pharmacological activity such as change, anti-aging, hypoglycemic, reducing blood lipid, antitumor, anti-mutagenesis, radiation protection.
In recent years, with people to berry recognize it is gradual deepen and the continuous improvement of health care consciousness, raspberry, sea-buckthorn, Chinese holly
The berry full of nutrition such as Qi increasingly receives an acclaim.Therefore, break berry tradition edible way, intensive processing is carried out, to reality
The higher value application of existing berry has very important significance.Raspberry, sea-buckthorn, matrimony vine berry fruit powder are prepared into compound by the present invention
Composition yet there are no the report for using triple combination.
Invention content
The purpose of the present invention is to provide one kind based on raspberry, sea-buckthorn, Chinese wolfberry fruit powder composition.Another object of the present invention
It is to provide the purposes of the fruit powder composition.
Specifically, the present invention provides a kind of raspberry, sea-buckthorn, Chinese wolfberry fruit powder compositions, it is to include following weight proportion
Raw material composition：
5~20 parts of raspberry fruit powder, 5~20 parts of seabuckthorn fruit powder, 5~20 parts of Chinese wolfberry fruit powder.
Specifically, it is made of the raw material of following weight proportion：
10 parts of raspberry fruit powder, 10 parts of seabuckthorn fruit powder, 10 parts of Chinese wolfberry fruit powder.
Wherein, the raspberry fruit powder, seabuckthorn fruit powder, Chinese wolfberry fruit powder are to be prepared one of by the following method：
Method one：Raspberry, sea-buckthorn, Chinese wolfberry fruit are taken respectively, after dry, be crushed to 600~800 mesh, respectively obtained raspberry
Fruit powder, seabuckthorn fruit powder, Chinese wolfberry fruit powder；
Method two：Raspberry, sea-buckthorn, Chinese wolfberry fruit are taken respectively, is squeezed the juice, is filtered, and after fruit juice spray drying, respectively obtain raspberry
Fruit powder, seabuckthorn fruit powder, Chinese wolfberry fruit powder；
Method three：Raspberry, sea-buckthorn, Chinese wolfberry fruit are taken respectively, are extracted by solvent of water, after extracting solution spray drying,
Respectively obtain raspberry fruit powder, seabuckthorn fruit powder, Chinese wolfberry fruit powder.
Wherein, the composition is using the raw material of the proportioning as active constituent, in addition on food, health products or drug often
The preparation that auxiliary material or complementary ingredient are prepared.In actual use, it can be prepared different according to the market demand
Dosage form.
Further, the preparation is through gastrointestinal tract absorbable preparation.
Pharmaceutically acceptable auxiliary material of the present invention refers to the substance being included in addition to the active ingredient (s in dosage form, packet
Include but be not limited only to filler (diluent), lubricant (glidant or antitack agent), dispersant, wetting agent, adhesive, adjusting
Agent, solubilizer, antioxidant, bacteriostatic agent, emulsifier, disintegrant etc..Adhesive include syrup, Arabic gum, gelatin, sorbierite,
Tragacanth, cellulose and its derivates (such as microcrystalline cellulose, sodium carboxymethylcellulose, ethyl cellulose or hydroxypropyl methylcellulose
Element etc.), gelatine size, syrup, starch slurry or polyvinylpyrrolidone etc.；Filler include lactose, Icing Sugar, dextrin, starch and its
Derivative, cellulose and its derivates, inorganic calcium salt (such as calcium sulfate, calcium phosphate, calcium monohydrogen phosphate, precipitated calcium carbonate), sorb
Alcohol or glycine etc.；Lubricant includes superfine silica gel powder, magnesium stearate, talcum powder, aluminium hydroxide, boric acid, hydrogenated vegetable oil, poly- second
Glycol etc.；Disintegrant includes starch and its derivative (such as sodium carboxymethyl starch, Explotab, pregelatinized starch, improvement shallow lake
Powder, hydroxypropul starch, cornstarch etc.), polyvinylpyrrolidone or microcrystalline cellulose etc.；Wetting agent includes dodecyl sulphate
Sodium, water or alcohol etc.；Antioxidant packages are containing sodium sulfite, sodium hydrogensulfite, sodium pyrosulfite, dibutyl benzoic acid etc.；Bacteriostatic agent includes
0.5% phenol, 0.3% cresols, 0.5% anesin etc.；Conditioning agent includes hydrochloric acid, citric acid, potassium hydroxide (sodium), citron
Sour sodium and buffer (including phosphoric acid dioxy sodium and disodium hydrogen phosphate) etc.；Emulsifier includes Tween-80, aliphatic acid sorb
Smooth, pluronic gram F-68, lecithin, Fabaceous Lecithin etc.；Solubilizer includes Tween-80, bile, glycerine etc..
The pharmaceutically acceptable complementary ingredient, it has certain physiological activity, but the addition of the ingredient will not change
Become leading position of the said extracted object in treatment of diseases, and only play auxiliary effect, these auxiliary effects are only
Utilization to the ingredient known activity is the usual adjuvant treatment modality of field of medicaments.If by above-mentioned complementary ingredient and this hair
Bright composition is used cooperatively, and still should belong to the scope of protection of the invention.
The present invention also provides raspberry, sea-buckthorn, matrimony vine berry fruit powder composition or above-mentioned composite chewable tablets to prepare antioxygen
Change the purposes in functional food, health products or drug.
Further, the food, health products or drug be scavenging hydroxyl, ultra-oxygen anion free radical or ABTS from
By the food, health products or drug of base.
Preferably, the food, health products or drug be the food for removing ultra-oxygen anion free radical or ABTS free radicals,
Health products or drug.
The present invention can be shown the study found that raspberry fruit powder, seabuckthorn fruit powder, Chinese wolfberry fruit powder are respectively provided with good anti-oxidation function
Write scavenging hydroxyl, ultra-oxygen anion free radical and ABTS free radicals.
The present invention in an experiment it has also been found that, raspberry, sea-buckthorn, Chinese wolfberry fruit powder composition antioxidant activity be substantially better than equally
The individual antioxidant activity of the lower three kinds of fruit powders of concentration (especially ultra-oxygen anion free radical or ABTS free radicals).Above-mentioned experiment knot
By sufficing to show that, raspberry provided by the invention, sea-buckthorn, Chinese wolfberry fruit powder composition have the function of synergy.
Description of the drawings
Fig. 1 raspberries, sea-buckthorn, Chinese wolfberry fruit powder combine the Scavenging activity to ABTS with three kinds of fruit powders
Fig. 2 raspberries, sea-buckthorn, Chinese wolfberry fruit powder are combined with three kinds of fruit powders to ultra-oxygen anion free radical Scavenging activity
Fig. 3 raspberries, sea-buckthorn, Chinese wolfberry fruit powder combine the Scavenging activity to hydroxy radical with three kinds of fruit powders
Specific embodiment
The preparation of the three seed pod compound powders of the invention of embodiment 1
Raspberry, sea-buckthorn, Chinese wolfberry fruit are taken respectively, after dry, are crushed to 600~800 mesh to get raspberry fruit powder, fructus hippophae
Powder and Chinese wolfberry fruit powder.According to the proportioning mixing of table 1 to get composition.
Table 1
| Ingredient | 1 (g) of group | 2 (g) of group | 3 (g) of group |
| Raspberry fruit powder | 10 | 5 | 20 |
| Seabuckthorn fruit powder | 10 | 20 | 5 |
| Chinese wolfberry fruit powder | 10 | 20 | 5 |
Antioxidation activity in vitro is tested
(1) material：Raspberry fruit powder, seabuckthorn fruit powder, Chinese wolfberry fruit powder and three seed pod compound powders are (with reference to the embodiment of the present invention
It prepares for 1 group 1).
(2) laboratory apparatus and reagent：Tube centrifuge (TGL-16G-A types, Anting Scientific Instrument Factory, Shanghai)；It is it can be seen that ultraviolet
Spectrophotometer (UV-722N, Shanghai Ni Ke Co., Ltds)；Thermostat water bath (HD types, Constant Temp. Instrument Factory, Liaoyang). ABTS
It is purchased from Shanghai Jing Chun biochemical technologies limited company (Aladdin)；Potassium peroxydisulfate, sodium dihydrogen phosphate, disodium hydrogen phosphate, chlorination
The reagents such as sodium, trichloroacetic acid are purchased from Shandong YuWang Industry Co., Ltd；Superoxide anion kit, hydroxy radical kit are equal
It is purchased from Nanjing and builds up bio tech ltd.
(3) ABTS Scavenging activities：ABTS is dissolved into (+H2O) to final concentration of 7mmol/L, potassium peroxydisulfate is configured to
2.45mmol/L mixes the two solution, is positioned over dark, stirs 16h under room temperature；Then ABTS mixed solutions are used
It is 0.70 ± 0.02 that PBS solution (PH=7.0), which is diluted to its light absorption value (being surveyed at 734nm),；Raspberry, sea-buckthorn, three seed pod of matrimony vine
Powder and three seed pod compound powders respectively with distilled water be diluted to various concentration (0.5mg/mL, 1mg/mL, 2mg/mL, 4mg/mL,
8mg/mL and 16mg/mL)；Finally the sample of above-mentioned various concentration is added in ABTS mixed solutions, sample is mixed with ABTS
It is 1 to close solution proportion:20, it mixes after being incubated 6min at room temperature, light absorption value is measured at 734nm.It is calculated clearly according to formula
Except rate.ABTS clearance rates (%)=(1- samples light absorption value/blank absorbency) × 100%.The result is shown in Figure 1
(4) ultra-oxygen anion free radical Scavenging activity：It is free that superoxide anion is generated using xanthine/xanthine oxidase
Base system of determination is to the Scavenging activity of superoxide radical.Raspberry, sea-buckthorn, three kinds of fruit powders of matrimony vine and three seed pod compound powders are distinguished
Various concentration (1mg/mL, 2mg/mL, 4mg/mL, 8mg/mL, 16mg/mL) is diluted to distilled water.Each group sequentially adds
75mmol/L phosphate buffers (pH7.8) 1ml, sample 0.2ml (control group is replaced with distilled water), 0.1mol/L hydrochloric acid hydroxyls
Amine aqueous solution 0.1ml, 75mmol/L xanthine solution 0.1ml and 0.037U/ml xanthine oxidase solution 0.1ml is uniformly mixed
27 DEG C of incubation 30min afterwards.2ml color developing agents (0.4g/L alpha naphthylamine+4g/L p-aminobenzene sulfonic acid) are added, are stood after mixing
Light absorption value on the downside of 5min, 530nm.Clearance rate is calculated according to formula.Ultra-oxygen anion free radical clearance rate (%)=1- samples
Light absorption value/blank absorbency × 100%.As a result see Fig. 2
(5) Hydroxyl radical-scavenging ability：Hydroxy radical is generated using Fenton reaction principles, is sent with sarranine developing dye
Measure the Scavenging activity to hydroxy radical.Raspberry, sea-buckthorn, three kinds of fruit powders of matrimony vine and three seed pod compound powders are used into distilled water respectively
It is diluted to various concentration (1mg/mL, 2mg/mL, 4mg/mL, 8mg/mL, 16mg/mL).Each group sequentially adds 0.15mol/L's
The EDTANa- of Tris-HCl buffer solutions (pH7.4) 1ml, 0.04mg/ml sarranine solution 1ml, distilled water 1ml, 0.945mmol/L
Fe2+Solution (pH7.4) 0.5ml, sample 0.5ml and 1%H2O2Solution 0.5ml is incubated 30min, control group distillation in 37 DEG C
Water replaces, blank group EDTANa-Fe2+Solution and sample are replaced with distilled water.Light absorption value is detected under 520nm.According to formula meter
Calculate clearance rate.Scavenging action to hydroxyl free radical (%)=1- samples light absorption value/blank absorbency × 100%.As a result see Fig. 3.
Claims (8)
1. a kind of raspberry, sea-buckthorn, Chinese wolfberry fruit powder composition, it is characterised in that：It is the raw material composition for including following weight proportion：
5~20 parts of raspberry fruit powder, 5~20 parts of seabuckthorn fruit powder, 5~20 parts of Chinese wolfberry fruit powder.
2. raspberry according to claim 1, sea-buckthorn, Chinese wolfberry fruit powder composition, it is characterised in that：Raspberry fruit powder:Fructus hippophae
Powder:Chinese wolfberry fruit powder=1:1:1.
3. raspberry according to claim 1 or 2, sea-buckthorn, Chinese wolfberry fruit powder composition, it is characterised in that：The raspberry fruit powder,
Seabuckthorn fruit powder, Chinese wolfberry fruit powder are to be prepared one of by the following method：
Method one：Take raspberry, sea-buckthorn, Chinese wolfberry fruit respectively, after dry, be crushed to 600~800 mesh, respectively obtain raspberry fruit powder,
Seabuckthorn fruit powder, Chinese wolfberry fruit powder；
Method two：Raspberry, sea-buckthorn, Chinese wolfberry fruit are taken respectively, is squeezed the juice, is filtered, and after fruit juice spray drying, respectively obtain raspberry fruit
Powder, seabuckthorn fruit powder, Chinese wolfberry fruit powder；
Method three：Raspberry, sea-buckthorn, Chinese wolfberry fruit are taken respectively, is extracted by solvent of water, after extracting solution spray drying, respectively
Obtain raspberry fruit powder, seabuckthorn fruit powder, Chinese wolfberry fruit powder.
4. according to the composition described in claims 1 to 3 any one, it is characterised in that：The composition is with the proportioning
Raw material for active constituent, in addition the preparation that common auxiliary material or complementary ingredient are prepared on food, health products or drug.
5. composition according to claim 4, it is characterised in that：The preparation is through gastrointestinal tract absorbable preparation.
6. raspberry, sea-buckthorn, Chinese wolfberry fruit powder composition have food, the health care of anti-oxidation efficacy in preparation described in claims 1 to 3
Purposes in product or drug.
7. purposes according to claim 6, it is characterised in that：The food, health products or drug be scavenging hydroxyl,
The food of ultra-oxygen anion free radical or ABTS free radicals, health products or drug.
8. purposes according to claim 7, it is characterised in that：The drug, health products or functional food are to remove ABTS
The drug of free radical or ultra-oxygen anion free radical, health products or functional food.
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