CN105558926A - Plateau berry fruit powder composition and tablet and use thereof - Google Patents

Plateau berry fruit powder composition and tablet and use thereof Download PDF

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Publication number
CN105558926A
CN105558926A CN201511010177.0A CN201511010177A CN105558926A CN 105558926 A CN105558926 A CN 105558926A CN 201511010177 A CN201511010177 A CN 201511010177A CN 105558926 A CN105558926 A CN 105558926A
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powder
fruit powder
parts
plateau
berry
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索有瑞
韩丽娟
胡娜
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Northwest Institute of Plateau Biology of CAS
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Northwest Institute of Plateau Biology of CAS
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/29Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

The present invention provides a plateau berry composition which is composed of the following raw materials proportioned in parts by weight: 1-5 parts of Chinese wolfberry fruit powder, 1-5 parts of Berberis dasystachya Maxim. fruit powder, 1-3 parts of Hippophae rhamnoides fruit powder and 1-10 parts of Nitraria fruit powder. Experiments on the present invention also reveal that anti-oxidation effects of the plateau berry fruit powder composition in most proportions are similar, however, the antioxidant effect of the plateau berry fruit powder composition in a proportion of ''2 parts of Chinese wolfberry fruit powder, 5 parts of Berberis dasystachya Maxim. fruit powder, 3 parts of Hippophae rhamnoides fruit powder and 1 part of Nitraria fruit powder'' is significantly better than that in other groups, and especially, is particularly prominent regarding the anti-superoxide anion free radical effect. Therefore, the anti-superoxide anion free radical effect of the above-mentioned proportion, as an optimum proportion of the present invention, can be used as the preferred use of the present invention.

Description

A kind of plateau berry fruit compound powder and tablet thereof and purposes
Technical field
The invention belongs to field of health care products, be specifically related to a kind of matrimony vine, yellow thorn, sea-buckthorn, Nitraria tangutorum berry fruit powder chewable tablet and preparation method thereof.
Technical background
Along with the quickening of modern life rhythm, the aggravation of social competition, the muscle power of people, the tired long term accumulation such as mental, psychological, the factors such as diet is unhealthy in addition, environmental radiation increases, cause people's interior free yl too much, make increasing people be in " inferior health " state.Free radical is a kind of asymmetric, unstable atom because losing an electronics or molecule, has very large energy.Free radical always attempts to capture an electronics to reach new balance, and the materials such as lipid, protein, carbohydrate and DNA for this reason in its meeting attack cells tissue, this just causes the peroxidating of lipid, the inactivation of the anaenzyme of protein, the oxidative damage etc. of DNA.In addition, when people are tired, can create a large amount of metabolins in body, as lactic acid, carbon dioxide, serum urea nitrogen etc., this kind of material gathers in vivo, stimulates human tissue cell and nervous system.Health is in fatigue state for a long time, can cause the adverse consequences such as hormone in vivo metabolism disorder, nervous system regulatory function exception, hypoimmunity.
White thorn (Nitraria) is zygophyllaceae (Zygophyllceae) plant, is that growth mainly builds one of mass-planting thing in the Gobi Desert Terrain area of height above sea level more than 3000 meters.Its strong stress resistance, drought-resistant saline and alkaline, be excellent shrub of checking winds and fixing drifting sand.White thorn ripe berry is aubergine, nontoxic edible, its fruit Middle nutrition composition and medicines and health protection active component kind many, rich content.Seed oil main component is the unrighted acids such as linoleic acid, leukotrienes, arachidonic acid, and wherein linoleic content is up to 70%, really belongs to exception in plant kingdom.And the effect of its antifatigue has bibliographical information, it has the function reducing lactic acid and urea nitrogen in the rear Mice Body of motion.
Sea-buckthorn is Elaeangnaceae hippophae plant (Hippophaerhamnoides), and it has another name called acid thorn, vinegar willow, black thorn.Sea-buckthorn all has extensive distribution in China the north and southwestern multiple provinces and regions, and its growth height above sea level is between 1000-4500 rice, and its plant also has very high Ecological Information and is worth.Its fruit is sour-sweet, nutritious, and pharmaceutical applications is worth greatly, in Application and Development to multiple product.The elite of its fruit is its seed oil.Existing many parts of reports are verified, and its seed oil also has vitamins, Polyphenols, aliphatic acid, waits various bioactivators, and more than its contained vitamin kind, the abundant any fruits and vegetables of content can not be compared, and therefore, are described as " vitamin treasure-house ".Meanwhile, scholar's research is also had to show, and other area plantation sea-buckthorn ratios, the Vitamin C content in Qinghai-Tibet sea buckthorn fruit is higher than other low altitude areas 2 times more than.
Yellow thorn, Berberidaceae plant straight fringe barberry BerberisdasystachyaMaxim., be with sting in vain, sea-buckthorn (black thorn) the same for covering, hiding, the medicinal traditional wild acinus with eating of ethnic group such as Uygur, be referred to as " Qinghai three is stung ".Containing the neutraceutical active ingredients that abundant vitamin, amino acid, polysaccharide etc. are abundant during yellow bur is real.Done concise and to the point description to straight fringe barberry fruit medicine function in " hiding mark " " hiding book on Chinese herbal medicine ", it has treatment stomachache, indigestion, abdominal distension, the functions such as dysentery.Yellow thorn seed accounts for the 41-46% of yellow thorn ripening fruits gross mass, and its grease-contained main component is unrighted acid, and the content as linoleic acid plus linolenic acid just account for nearly 60%, has high nutrition and medical value.
Qaidam matrimony vine cries again Qinghai matrimony vine, mainly produces the area such as Golmud, Dulan, Ulan, Delingha in the Caidamu Basin.Qaidam matrimony vine is because of the physical geography condition of its uniqueness and weather conditions, interior containing many reactive compounds, as amino acid, vitamin, aliphatic acid, polysaccharide, betaine etc.Detect according to Institute of Analysis of Northwest Plateau-organisms Research Inst. of Chinese Academy of Sciences, the many compositions in the matrimony vine of Qaidam are all higher than lycium barbarum.
Summary of the invention
The object of the present invention is to provide a kind of based on Qaidam matrimony vine, yellow thorn, sea-buckthorn, Nitraria tangutorum berry fruit compound powder and tablet.Another object of the present invention is to the purposes that said composition or tablet are provided.
Particularly, the invention provides a kind of plateau berry composition, it is made up of the raw material of following weight proportion:
Chinese wolfberry fruit powder 1 ~ 5 part, 1 ~ 5 part, yellow bur powder, seabuckthorn fruit powder 1 ~ 3 part, white 1 ~ 10 part, bur powder.
Preferably, it is made up of the raw material of following weight proportion:
Chinese wolfberry fruit powder 2 parts, 5 parts, yellow bur powder, seabuckthorn fruit powder 3 parts, white 1 part, bur powder.
Wherein, described Chinese wolfberry fruit powder, yellow bur powder, seabuckthorn fruit powder, white bur powder prepare one of by the following method:
Method one: get Qaidam matrimony vine, yellow thorn, sea-buckthorn or Nitraria tangutorum fruit, after drying, be crushed to 600 ~ 800 orders, obtains Chinese wolfberry fruit powder, yellow bur powder, seabuckthorn fruit powder or white bur powder;
Method two: get Qaidam matrimony vine, yellow thorn, sea-buckthorn or Nitraria tangutorum fruit, squeeze the juice, filter, after fruit juice spraying dry, obtains Chinese wolfberry fruit powder, yellow bur powder, seabuckthorn fruit powder or white bur powder;
Method three: getting Qaidam matrimony vine, yellow thorn, sea-buckthorn or Nitraria tangutorum fruit, is that solvent extracts with water, after extract spraying dry, obtains Chinese wolfberry fruit powder, yellow bur powder, seabuckthorn fruit powder or white bur powder.
Present invention also offers a kind of plateau berry tablet, it be with above-mentioned plateau berry composition for active component, also to comprise on tablet conventional auxiliary material.
Further, above-mentioned plateau berry composition accounts for 10 ~ 65% of tablet gross mass.
Further, the supplementary material weight proportion of described tablet is as follows:
Described plateau berry composition 10 ~ 65 parts, starch 10 ~ 40 parts, microcrystalline cellulose 10 ~ 25 parts, sucrose 10 ~ 18 weight portion, 0.4 ~ 1 part, sodium chloride, PEG60002 ~ 4 part;
Preferably, described plateau berry composition is made up of the raw material of following weight proportion: Chinese wolfberry fruit powder 2 parts, 5 parts, yellow bur powder, seabuckthorn fruit powder 3 parts, white 1 part, bur powder.
Tablet of the present invention can be chewable tablets.
Present invention also offers above-mentioned composition or above-mentioned tablet and possess purposes in the food of anti-oxidation efficacy, health products or medicine in preparation.
Further, described food, health products or medicine remove the food of ABTS free radical, ultra-oxygen anion free radical or hydroxy radical, health products or medicine.
Preferably, described food, health products or medicine remove the food of ultra-oxygen anion free radical, health products or medicine.
The present invention studies discovery, and plateau berry mixing fruit powder has good anti-oxidation function, can remarkable anti-hydroxy radical/ultra-oxygen anion free radical, and ABTS free radical.
The present invention also finds in an experiment, plateau berry fruit compound powder is under most proportioning, its antioxidation is similar, but, under " Chinese wolfberry fruit powder 2 parts, 5 parts, yellow bur powder, seabuckthorn fruit powder 3 parts, white 1 part, bur powder " this proportioning, the antioxidation activity of composition is obviously better than other each group, performance particularly on superoxide anion resisitance free radical is particularly outstanding, therefore, said ratio is as optimum ratio of the present invention, and the effect of its antagonism ultra-oxygen anion free radical can as preferable use of the present invention; Meanwhile, the antioxidation activity of above-mentioned optimum proportioning is also significantly better than each single fruit powder.Above-mentioned experiment conclusion suffices to show that, 4 kinds of fruit powder under specific consumption proportion, have been played synergistic function by the present invention.
In addition, fruit powder specific area is excessive, and easy moisture absorption, should not store, and be not easy to plug and play.In view of the foregoing, matrimony vine, yellow thorn, sea-buckthorn, Nitraria tangutorum fruit powder are prepared into tablet by the present invention, are namely convenient to the storage of product, transport and packaging, are also convenient to all kinds of crowd simultaneously and use.
Detailed description of the invention
The preparation of embodiment 1 present composition
Get Qaidam matrimony vine, yellow thorn, sea-buckthorn or Nitraria tangutorum fruit respectively, after drying, be crushed to 600 ~ 800 orders, obtain Chinese wolfberry fruit powder, yellow bur powder, seabuckthorn fruit powder or white bur powder.
Each fruit powder is carried out proportioning mixing with Chinese wolfberry fruit powder 2 parts, 5 parts, yellow bur powder, seabuckthorn fruit powder 3 parts, white 1 part, bur powder, obtains the present composition.
The preparation of embodiment 2 Tablets
Table 1
Plateau berry composition Group 1 Group 2 Group 3
Chinese wolfberry fruit powder 6% 8% 10%
Yellow bur powder 15% 20% 25%
Seabuckthorn fruit powder 9% 12% 15%
White bur powder 3% 4% 5%
Microcrystalline cellulose 22% 20% 10%
Starch 30% 21% 20%
Sucrose 10% 10% 10%
Sodium chloride 1% 1% 1%
PEG6000 4% 4% 4%
Antioxidation activity in vitro is tested
(1) material: plateau berry fruit powder: be ultramicro grinding gained fruit powder, prepare with reference to the embodiment of the present invention 1, each fruit powder combination matching is see table 2.
(2) laboratory apparatus and reagent: TGL-16G-A type tube centrifuge, Anting Scientific Instrument Factory, Shanghai; UV-722N visible ultraviolet spectrophotometer, Shanghai Ni Ke Co., Ltd; HD type thermostat water bath, Constant Temp. Instrument Factory, Liaoyang.DPPH, ABTS are purchased from Shanghai Jing Chun biochemical technology limited company (Aladdin); The reagent such as potassium peroxydisulfate, sodium dihydrogen phosphate, sodium hydrogen phosphate, sodium chloride, trichloroacetic acid are all purchased from Shandong YuWang Industry Co., Ltd; Superoxide anion kit, hydroxy radical kit are all purchased from Nanjing and build up bio tech ltd.
(3) ABTS Scavenging activity: it is 7mmol/L that ABTS is dissolved (+H2O) to final concentration, and potassium peroxydisulfate is mixed with 2.45mmol/L, mixes the two solution, is positioned over dark, stirs 16h under room temperature condition; Then ABTS mixed solution PBS solution (PH=7.0) being diluted to its light absorption value (surveying in 734nm place) is 0.70 ± 0.02; Four kinds of plateau berry fruit powder weigh up rear distilled water by required weight ratio and are made into the mixing suspension that final concentration is 16mg/mL; Finally join in ABTS mixed solution by the sample of above-mentioned concentration, its sample and ABTS mixed solution ratio are 1: 20, in incubated at room temperature 6min after mixing, measure light absorption value in 734nm place.
Computing formula: ABTS clearance rate (%)=(1-A sample/ A control) × 100%
Wherein A controlfor the light absorption value of ABTS mixed solution; A samplefor the light absorption value measured after adding sample in ABTS mixed solution.
(4) ultra-oxygen anion free radical Scavenging activity and hydroxy radical all adopt Nanjing to build up kit detection.Wherein, four kinds of plateau berry fruit powder weigh up rear distilled water by required weight ratio and are made into the mixing suspension that final concentration is 16mg/mL.
Table 2
The present invention finds in previous experiments, and the fruit compound powder prepared according to rear 5 proportionings in table 2, all has good antioxidation activity, and each group activity is comparatively similar; But inventor is surprised to find that, when fruit compound powder proportioning is " Chinese wolfberry fruit powder 2 parts, 5 parts, yellow bur powder, seabuckthorn fruit powder 3 parts, white 1 part, bur powder ", the antioxidation activity of composition is significantly improved, particularly the ability of superoxide anion resisitance free radical improves particularly remarkable, therefore 1st proportioning of the present invention preferably in table 2; Meanwhile, the antioxidation activity of above-mentioned optimum proportioning is also significantly better than each single fruit powder.Above-mentioned experiment conclusion suffices to show that, 4 kinds of fruit powder under specific consumption proportion, have been played synergistic function by the present invention.

Claims (10)

1. a plateau berry composition, is characterized in that: it is made up of the raw material of following weight proportion:
Chinese wolfberry fruit powder 1 ~ 5 part, 1 ~ 5 part, yellow bur powder, seabuckthorn fruit powder 1 ~ 3 part, white 1 ~ 10 part, bur powder.
2. plateau according to claim 1 berry composition, is characterized in that: it is made up of the raw material of following weight proportion:
Chinese wolfberry fruit powder 2 parts, 5 parts, yellow bur powder, seabuckthorn fruit powder 3 parts, white 1 part, bur powder.
3. plateau according to claim 1 and 2 berry composition, is characterized in that: described Chinese wolfberry fruit powder, yellow bur powder, seabuckthorn fruit powder, white bur powder prepare one of by the following method:
Method one: get Qaidam matrimony vine, yellow thorn, sea-buckthorn or Nitraria tangutorum fruit, after drying, be crushed to 600 ~ 800 orders, obtains Chinese wolfberry fruit powder, yellow bur powder, seabuckthorn fruit powder or white bur powder;
Method two: get Qaidam matrimony vine, yellow thorn, sea-buckthorn or Nitraria tangutorum fruit, squeeze the juice, filter, after fruit juice spraying dry, obtains Chinese wolfberry fruit powder, yellow bur powder, seabuckthorn fruit powder or white bur powder;
Method three: getting Qaidam matrimony vine, yellow thorn, sea-buckthorn or Nitraria tangutorum fruit, is that solvent extracts with water, after extract spraying dry, obtains Chinese wolfberry fruit powder, yellow bur powder, seabuckthorn fruit powder or white bur powder.
4. a plateau berry tablet, is characterized in that: it be with berry composition in plateau described in claims 1 to 3 for active component, also to comprise on tablet conventional auxiliary material.
5. plateau according to claim 4 berry tablet, is characterized in that: described in described claims 1 to 3, plateau berry composition accounts for 10 ~ 65% of tablet gross mass.
6. plateau according to claim 5 berry tablet, is characterized in that: the supplementary material weight proportion of described tablet is as follows:
Described plateau berry composition 10 ~ 65 parts, starch 10 ~ 40 parts, microcrystalline cellulose 10 ~ 25 parts, sucrose 10 ~ 18 weight portion, 0.4 ~ 1 part, sodium chloride, PEG60002 ~ 4 part;
7. plateau according to claim 6 berry tablet, is characterized in that: described plateau berry composition is made up of the raw material of following weight proportion: Chinese wolfberry fruit powder 2 parts, 5 parts, yellow bur powder, seabuckthorn fruit powder 3 parts, white 1 part, bur powder.
8. tablet described in composition described in claims 1 to 3 or claim 4 ~ 7 possesses the purposes in the food of anti-oxidation efficacy, health products or medicine in preparation.
9. purposes according to claim 8, is characterized in that: described food, health products or medicine remove the food of ABTS free radical, ultra-oxygen anion free radical or hydroxy radical, health products or medicine.
10. purposes according to claim 9, is characterized in that: described food, health products or medicine remove the food of ultra-oxygen anion free radical, health products or medicine.
CN201511010177.0A 2015-12-18 2015-12-18 Plateau berry fruit powder composition and tablet and use thereof Pending CN105558926A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108185342A (en) * 2018-01-24 2018-06-22 中国科学院西北高原生物研究所 A kind of composition containing seabuckthorn fruit powder and application thereof
CN108323757A (en) * 2018-01-24 2018-07-27 中科果悦湖州生物科技开发有限公司 A kind of composite chewable tablet with anti-oxidation efficacy
CN108378369A (en) * 2018-01-24 2018-08-10 中科果悦湖州生物科技开发有限公司 A kind of complex polysaccharide effervescent tablet of anti-oxidation efficacy

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1260147A (en) * 1999-09-20 2000-07-19 青海省青藏高原生物制品有限公司 Wolfberry fruit juice beverage

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1260147A (en) * 1999-09-20 2000-07-19 青海省青藏高原生物制品有限公司 Wolfberry fruit juice beverage

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108185342A (en) * 2018-01-24 2018-06-22 中国科学院西北高原生物研究所 A kind of composition containing seabuckthorn fruit powder and application thereof
CN108323757A (en) * 2018-01-24 2018-07-27 中科果悦湖州生物科技开发有限公司 A kind of composite chewable tablet with anti-oxidation efficacy
CN108378369A (en) * 2018-01-24 2018-08-10 中科果悦湖州生物科技开发有限公司 A kind of complex polysaccharide effervescent tablet of anti-oxidation efficacy

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Application publication date: 20160511