CN108310198A - It is a kind of to be used to treat medicament of childhood eczema and preparation method thereof - Google Patents

It is a kind of to be used to treat medicament of childhood eczema and preparation method thereof Download PDF

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Publication number
CN108310198A
CN108310198A CN201810406308.4A CN201810406308A CN108310198A CN 108310198 A CN108310198 A CN 108310198A CN 201810406308 A CN201810406308 A CN 201810406308A CN 108310198 A CN108310198 A CN 108310198A
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parts
medicament
peppermint
spare
eczema
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李�远
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238—Saposhnikovia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8967—Lilium, e.g. tiger lily or Easter lily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Alternative & Traditional Medicine (AREA)
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  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention relates to a kind of medicaments and preparation method thereof for treating childhood eczema, the active constituent of the medicament is by purslane, Semen Lablab Album, Chinese yam, the achene of Siberian cocklebur, windproof, brown sugar, lily and peppermint are prepared, the present invention is by the way of topical administration, used raw material toxic side effect is small, non-corrosive or narcotic drugs, in addition by the way of topical administration, safety is ensured well, is especially suitable for the eczema treatment gesture of newborn and children's early stage.

Description

It is a kind of to be used to treat medicament of childhood eczema and preparation method thereof
Technical field
The present invention relates to a kind of Chinese patent drugs and preparation method thereof, more particularly to a kind of medicament for treating childhood eczema And preparation method thereof.
Background technology
Infantile eczema, i.e. atopic dermatitis (atopic dermatitis, AD), also known as atopic dermatitis, dystopy Property dermatitis, be a kind of chronic, recurrent, inflammatory dermatoses.It falls ill, and delays to children and adult more than infant period Phase.With eczema sample fash, with violent itch, recurrent exerbation is clinical characters, often there is that apparent " spy answers in sufferer or family Property ", seriously affect quality of life.Mainly to ingestant, inhalation (inhalatio) or contactant do not tolerate or allergy caused by.With eczema Child originally rubefaction, occur fash, followed by skin send out rough, furfur, stroke the skin of child as touched one on sand paper Sample.Heat, chance are wet can all to make eczema performance notable.
There are the following problems for common medicament on the market：First, Chinese medicine eczema ointment 100% contains hormone, also therefore to wet Rash has certain curative effect；Second, the Chinese medicine ointment treated to childhood eczema is marked, hormone-content is used to adult 5.2 times --- the highest a eczema ointment containing hormone is also exactly used to baby.
Chinese medicine treatment eczema is of long standing and well established, with a long history, and China gradually develops and sets up by long-term practice Medical method is the important wealth of China's traditional Chinese medicine treasure-house.Such as《It cures ancestor's gold and irrigates surgery heart method》Acute eczema is recorded:" at the beginning of this disease It is raw such as scabies, itch without when, sprawling is more than, grabs Tianjin yellow water, and contamination is in blocks.”
The present invention has used for reference the dialectical main points and experience that skill and technique is controlled outside eczema of all times, according to the four methods of diagnosis and eight key links of Chinese medicine and Treatment eight treating observances develops, emphasis is dialectical with stadium, syndrome differentiation of zang-fu viscera, skin lesion are dialectical and channels and collaterals position it is dialectical based on, treatment with Clearing away heat and eliminating dampeness, wind-dispelling, cooperation skin massaging, scraping gimmick, achieve the purpose that improvement, alleviate symptom.
Invention content
The purpose of the present invention is to provide a kind of medicaments for treating childhood eczema, by the way of topical administration, power It asks treatment cycle short, has no toxic side effect.To achieve the above object, present invention employs following technical schemes：One kind is for treating The active constituent of the medicament of childhood eczema, medicament is made of following raw material：Purslane is Semen Lablab Album, Chinese yam, the achene of Siberian cocklebur, windproof, red Sugar, lily and peppermint；The parts by weight of the raw material are respectively：5~25 parts of purslane, 5~30 parts of Semen Lablab Album, Chinese yam 5~35 Part, 5~20 parts of the achene of Siberian cocklebur, windproof 5~30 parts, 5~20 parts of brown sugar, 10~25 parts of lily, 0.1~10 part of peppermint.
The preferable parts by weight of raw material are respectively：20~25 parts of purslane, 5~8 parts of Semen Lablab Album, 5~8 parts of Chinese yam, 8~15 parts of the achene of Siberian cocklebur, windproof 5~8 parts, 15~20 parts of brown sugar, 15~20 parts of lily, 0.1~10 part of peppermint.
It is a further object of the present invention to provide a kind of method preparing above-mentioned medicament, can abundant effective component extracting and Impurity can be removed most possibly, and is suitble to the requirement of industrialized production, included the following steps：
The preparation method of the medicament, it is characterised in that include the following steps：
(1) purslane, achene of Siberian cocklebur slice or segment are taken, with Semen Lablab Album, Chinese yam, it is windproof with 5~10 times of medicinal material amounts go from Sub- water decocts 1~3 time, and 1~3h, merges gained decoction liquor, filtered with 200 mesh gauzes, at gained concentrating filter liquor, freeze-drying every time It manages to powdered spare；
(2) brown sugar, lily slice or segment are taken, 1~3 time is decocted with the deionized water of 5~10 times of medicinal material amounts, every time 1~ 3h merges gained decoction liquor, is filtered with 200 mesh gauzes, and gained concentrating filter liquor, frozen dried are to powdered spare；
(3) peppermint be crushed into 40~100 mesh sieve, it is spare；
(4) after mixing by extract spare in step (1), (2), spare peppermint is added in step (3) to get this The active constituent of invention medicament；Active constituent is dissolved in 25% ethanol solution of 1~50 times of active principle, is uniformly mixed simultaneously After sterilized processing, the medicament for treating childhood eczema is obtained.
The medicament for treating childhood eczema prepared using above-mentioned technical proposal has following advantages：
1. the present invention has apparent curative effect in actual use, by the way of topical administration, pain can be mitigated within 2-3 days, 5 days It can fully recover, patient is made fundamentally to be effectively treated, the advantage for having the corrosive medicines such as eczema ointment irreplaceable；
2. the active constituent of Chinese medicine of the present invention is by purslane, Semen Lablab Album, Chinese yam, the achene of Siberian cocklebur, windproof, brown sugar, lily and Peppermint is made, and used raw material toxic side effect is small, non-corrosive or narcotic drugs, in addition by the way of topical administration, Safety is ensured well, is especially suitable for the eczema treatment of newborn and children's early stage；
3. the dosage form of the present invention is based on lotion, easy to use, beautiful；
4. the present invention provides a kind of operating processes simply, the preparation side of the medicament for treating childhood eczema of low cost Method.
Specific implementation mode
With reference to specific embodiment, the present invention is further described：
Embodiment 1
(1) 5 parts of purslane, 5 parts of slices of the achene of Siberian cocklebur or segment are taken, with 5 parts of Semen Lablab Album, 5 parts of Chinese yam, windproof 5 parts of use, 5 times of medicines The deionized water of material amount decocts 1 time, each 1h, merges gained decoction liquor, is filtered with 200 mesh gauzes, and gained concentrating filter liquor is frozen Dry-cure is to powdered spare；
(2) 5 parts of brown sugar, 10 parts of slices of lily or segment are taken, is decocted 1 time, each 1h with the deionized water of 5 times of medicinal material amounts, Merge gained decoction liquor, filtered with 200 mesh gauzes, gained concentrating filter liquor, frozen dried are to powdered spare；
(3) after mixing by extract spare in step (1), (2), 0.1 part of peppermint for smashing 40 mesh sieve is added, Up to the active constituent of medicament of the present invention；Active constituent is dissolved in 25% ethanol solution of 1 times of active principle, is uniformly mixed And after sterilized processing, the medicament for treating childhood eczema is obtained.
Embodiment 2
(1) 25 parts of purslane, 20 parts of slices of the achene of Siberian cocklebur or segment are taken, with 30 parts of Semen Lablab Album, 35 parts of Chinese yam, windproof 30 parts of use The deionized water of 10 times of medicinal material amounts decocts 3 times, each 3h, merges gained decoction liquor, is filtered with 200 mesh gauzes, gained filtrate warp Concentration, frozen dried are to powdered spare；
(2) 20 parts of brown sugar, 25 parts of lily slice or segment are taken, decocts 3 times with the deionized water of 10 times of medicinal material amounts, every time 3h merges gained decoction liquor, is filtered with 200 mesh gauzes, and gained concentrating filter liquor, frozen dried are to powdered spare；
(3) after mixing by extract spare in step (1), (2), 10 parts of the peppermint for smashing and sieving with 100 mesh sieve is added, Up to the active constituent of medicament of the present invention；Active constituent is dissolved in 25% ethanol solution of 50 times of active principles, mixing is equal After even and sterilized processing, the medicament for treating childhood eczema is obtained.
Embodiment 3
(1) 20 parts of purslane, 8 parts of slices of the achene of Siberian cocklebur or segment are taken, with 5 parts of Semen Lablab Album, 5 parts of Chinese yam, windproof 5 times of 5 parts of use The deionized water of medicinal material amount decocts 1 time, each 1h, merges gained decoction liquor, is filtered with 200 mesh gauzes, gained concentrating filter liquor, Frozen dried is to powdered spare；
(2) 15 parts of brown sugar, 15 parts of slices of lily or segment are taken, is decocted 1 time, each 1h with the deionized water of 5 times of medicinal material amounts, Merge gained decoction liquor, filtered with 200 mesh gauzes, gained concentrating filter liquor, frozen dried are to powdered spare；
(3) after mixing by extract spare in step (1), (2), 0.1 part of peppermint for smashing 40 mesh sieve is added, Up to the active constituent of medicament of the present invention；Active constituent is dissolved in 25% ethanol solution of 1 times of active principle, is uniformly mixed And after sterilized processing, the medicament for treating childhood eczema is obtained.
Embodiment 4
(1) 25 parts of purslane, 15 parts of slices of the achene of Siberian cocklebur or segment are taken, with 8 parts of Semen Lablab Album, 8 parts of Chinese yam, windproof 8 parts of use 10 The deionized water of times medicinal material amount decocts 3 times, each 3h, merges gained decoction liquor, is filtered with 200 mesh gauzes, gained filtrate is through dense Contracting, frozen dried are to powdered spare；
(2) 20 parts of brown sugar, 20 parts of lily slice or segment are taken, decocts 3 times with the deionized water of 10 times of medicinal material amounts, every time 3h merges gained decoction liquor, is filtered with 200 mesh gauzes, and gained concentrating filter liquor, frozen dried are to powdered spare；
(3) after mixing by extract spare in step (1), (2), 10 parts of the peppermint for smashing and sieving with 100 mesh sieve is added, Up to the active constituent of medicament of the present invention；Active constituent is dissolved in 25% ethanol solution of 50 times of active principles, mixing is equal After even and sterilized processing, the medicament for treating childhood eczema is obtained.
Administrated method：When first medication, hot water hot compress eczema affected part is first used, the liquid medicine obtained of the present invention is coated on and is suffered from Place, it is 3-4 times daily.
Therapeutic effect：
(1) criterion of therapeutical effect：
Specific curative effect point or less three-level：Cure --- eczema symptom all disappears；
Improving --- eczema symptom is substantially reduced；
In vain --- after medication 1 week, eczema symptom does not change.
(2) effect：With drug therapy eczema patients 100 of the present invention, cure rate 100%, general 2-3 days eczema disappears It loses, can cure within 5 days, it is very good for newborn or child adjustment, it there is no adverse reaction.

Claims (3)

1. a kind of medicament for treating childhood eczema, it is characterised in that the active constituent of medicament is made of following raw material：Dent Amaranth, Semen Lablab Album, Chinese yam, the achene of Siberian cocklebur, windproof, brown sugar, lily and peppermint；The parts by weight of the raw material are respectively：Purslane 5~ 25 parts, 5~30 parts of Semen Lablab Album, 5~35 parts of Chinese yam, 5~20 parts of the achene of Siberian cocklebur, windproof 5~30 parts, 5~20 parts of brown sugar, lily 10~ 25 parts, 0.1~10 part of peppermint.
2. the medicament according to claim 1 for treating childhood eczema, it is characterised in that the preferable weight of raw material Number is respectively：20~25 parts of purslane, 5~8 parts of Semen Lablab Album, 5~8 parts of Chinese yam, 8~15 parts of the achene of Siberian cocklebur, windproof 5~8 parts, red Sugared 15~20 parts, 10~20 parts of lily, 0.1~10 part of peppermint.
3. the preparation method of medicament according to claim 1 or claim 2, it is characterised in that include the following steps：
(1) purslane, achene of Siberian cocklebur slice or segment are taken, with Semen Lablab Album, Chinese yam, the windproof deionized water with 5~10 times of medicinal material amounts It decocts 1~3 time, 1~3h, merges gained decoction liquor, filtered with 200 mesh gauzes, gained concentrating filter liquor, frozen dried are extremely every time It is powdered spare；
(2) brown sugar, lily slice or segment are taken, is decocted 1~3 time with the deionized water of 5~10 times of medicinal material amounts, 1~3h, is closed every time And gained decoction liquor, it is filtered with 200 mesh gauzes, gained concentrating filter liquor, frozen dried are to powdered spare；
(3) peppermint be crushed into 40~100 mesh sieve, it is spare；
(4) after mixing by extract spare in step (1), (2), spare peppermint is added in step (3) to get the present invention The active constituent of medicament；Active constituent is dissolved in 25% ethanol solution of 1~50 times of active principle, is uniformly mixed and through going out After bacterium processing, the medicament for treating childhood eczema is obtained.
CN201810406308.4A 2018-04-30 2018-04-30 It is a kind of to be used to treat medicament of childhood eczema and preparation method thereof Pending CN108310198A (en)

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CN201810406308.4A CN108310198A (en) 2018-04-30 2018-04-30 It is a kind of to be used to treat medicament of childhood eczema and preparation method thereof

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102451335A (en) * 2010-10-22 2012-05-16 张圣进 Self-made formula for treating eczema and its preparation method
CN103860976A (en) * 2014-03-24 2014-06-18 李周全 Drug composition for treating infantile dermatitis
CN105748684A (en) * 2016-04-08 2016-07-13 黄庆辉 Traditional Chinese medicine composition for treating damp-heat eczema

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102451335A (en) * 2010-10-22 2012-05-16 张圣进 Self-made formula for treating eczema and its preparation method
CN103860976A (en) * 2014-03-24 2014-06-18 李周全 Drug composition for treating infantile dermatitis
CN105748684A (en) * 2016-04-08 2016-07-13 黄庆辉 Traditional Chinese medicine composition for treating damp-heat eczema

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
王济平: "马齿苋皮科应用一得", 《中国民间疗法》 *

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Application publication date: 20180724