CN108309834A - Skin care compositions based on brown alga extract - Google Patents
Skin care compositions based on brown alga extract Download PDFInfo
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- CN108309834A CN108309834A CN201810355784.8A CN201810355784A CN108309834A CN 108309834 A CN108309834 A CN 108309834A CN 201810355784 A CN201810355784 A CN 201810355784A CN 108309834 A CN108309834 A CN 108309834A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/927—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of insects, e.g. shellac
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
Abstract
A kind of skin care compositions based on brown alga extract, including Algisium C, dimethyl-silicon alkanol, brown alga extract, nano zinc powder, nucleoprotamine, beeswax and water, the mass parts of Algisium C are 35 parts 40 parts, the mass parts of dimethyl-silicon alkanol are 35 parts 40 parts, the mass parts of brown alga extract are 9 parts 12 parts, the mass parts of nano zinc powder are 0.3 part 0.35 part, the mass parts of nucleoprotamine are 2.5 parts 3.5 parts, the mass parts of beeswax are 2 parts 4 parts, and the mass parts of water are 50 parts 55 parts.The above-mentioned skin care compositions based on brown alga extract, using brown alga extract as main active, contain fucoidin in brown alga extract, it has preferable anti-oxidant, anti-aging effects, filler of the fucoidin as cell wall, when being applied in skin care compositions, also there is preferable moisturizing and water lock effect.
Description
Technical field
The present invention relates to natural products and technical field of daily necessities, more particularly to a kind of skin care based on brown alga extract
Composition.
Background technology
Brown alga, Classification system Phaeophyta, most of is marine products algae, counts roughly more than 1500 kinds, mainly lives in
In seawater.Minority is raw in fresh water area, about 10 kinds or so, as China Jia Lingjiang River is lived two kinds of brown algas.Brown alga is distributed more
Extensively, well known such as kelp, undaria pinnitafida, sargassum fusifome, kelp belong to brown alga.
With the development of science and technology, the development and utilization of brown alga has great influence for the embodiment of its economic value.
Fucoidin wherein in brown alga has splendid application value.It is therefore desirable to develop a kind of skin care based on brown alga extract
Composition.
Invention content
Based on this, it is necessary to provide a kind of skin care compositions based on brown alga extract.
A kind of skin care compositions based on brown alga extract, including Algisium C, dimethylsilane
The mass parts of alcohol, brown alga extract, nano zinc powder, nucleoprotamine, beeswax and water, the Algisium C are
35 parts -40 parts, the mass parts of the dimethyl-silicon alkanol are 35 parts -40 parts, and the mass parts of the brown alga extract are 9 part -12
Part, the mass parts of the nano zinc powder are 0.3 part -0.35 part, and the mass parts of the nucleoprotamine are 2.5 parts -3.5 parts, described
The mass parts of beeswax are 2 parts -4 parts, and the mass parts of the water are 50 parts -55 parts.
The skin care compositions based on brown alga extract further includes emulsifier in one of the embodiments,.
The mass parts of the emulsifier are 0.5 part -1 part in one of the embodiments,.
The emulsifier is Sodium Polyacrylate in one of the embodiments,.
The quality of the Algisium C and the dimethyl-silicon alkanol in one of the embodiments,
Than being 1：1.
The skin care compositions based on brown alga extract further includes leucine, valine and different in one of the embodiments,
Leucine.
The mass parts of the leucine are 0.05 part -0.15 part in one of the embodiments,.
The mass parts of the valine are 0.12 part -0.18 part in one of the embodiments,.
The mass parts of the isoleucine are 0.08 part -0.15 part in one of the embodiments,.
The mass ratio of the leucine, the valine and the isoleucine is 1 in one of the embodiments,：
1.4：0.9.
The above-mentioned skin care compositions based on brown alga extract, using brown alga extract as main active, brown alga extract
In contain fucoidin, there is preferable anti-oxidant, anti-aging effects, filler of the fucoidin as cell wall, general
When it is applied in skin care compositions, also there is preferable moisturizing and water lock effect.Especially brown alga extract and nucleoprotamine
When being used together, certain nutritional supplementation effect can be mentioned to skin, is conducive to repair damaged cell.By adding Nano-Zinc
The mass parts of powder, the nano zinc powder are 0.3 part -0.35 part, can enhance the free radical scavenging ability of body Skin Cell, especially
It is nano zinc powder when brown alga extract is used together, and oxidation resistance and free radical scavenging ability effect to skin are all
With certain facilitation.By using Algisium C, when brown alga extract is used together,
Moistening effect is more preferable, can increase product silk smooth felling, and can delaying skin dried-up time.By using dimethyl-silicon alkanol,
When brown alga extract is used together, certain removing or inhibiting effect can also be played to the wrinkle of skin, so as to
The aging of enough delaying skins.By adding beeswax, other than it can play the role of certain nutritional supplementation to skin, additionally it is possible to have
There is certain bacteriostasis, the storage time of skin care compositions can be extended.
Specific implementation mode
It to facilitate the understanding of the present invention, below will be to invention is more fully described.This is given in embodiment
The better embodiment of invention.But the present invention can realize in many different forms, however it is not limited to described herein
Embodiment.On the contrary, the purpose of providing these embodiments is that making to understand the disclosure more thorough complete
Face.Certainly, they are merely examples, and is not intended to limit the present invention.In addition, the present invention can weigh in different examples
Multiple reference number and/or letter.This repetition is for purposes of simplicity and clarity, itself not indicate discussed various implementations
Relationship between example and/or setting.Unless otherwise defined, all of technologies and scientific terms used here by the article and belong to this hair
The normally understood meaning of bright those skilled in the art is identical.It is specific that term used herein is intended merely to description
The purpose of embodiment, it is not intended that in the limitation present invention.Term " and or " used herein includes one or more related
Listed Items any and all combinations.
For example, a kind of skin care compositions based on brown alga extract, which is characterized in that including methyl-monosilane alcohol sweet dew alditol
Acid esters, dimethyl-silicon alkanol, brown alga extract, nano zinc powder, nucleoprotamine, beeswax and water, the methyl-monosilane alcohol mannose
The mass parts of aldehydic acid ester are 35 parts -40 parts, and the mass parts of the dimethyl-silicon alkanol are 35 parts -40 parts, the brown alga extract
Mass parts be 9 parts -12 parts, the mass parts of the nano zinc powder are 0.3 part -0.35 part, and the mass parts of the nucleoprotamine are
2.5 parts -3.5 parts, the mass parts of the beeswax are 2 parts -4 parts, and the mass parts of the water are 50 parts -55 parts.
The above-mentioned skin care compositions based on brown alga extract, using brown alga extract as main active, brown alga extract
In contain fucoidin, there is preferable anti-oxidant, anti-aging effects, filler of the fucoidin as cell wall, general
When it is applied in skin care compositions, also there is preferable moisturizing and water lock effect.Especially brown alga extract and nucleoprotamine
When being used together, certain nutritional supplementation effect can be mentioned to skin, is conducive to repair damaged cell.By adding Nano-Zinc
The mass parts of powder, the nano zinc powder are 0.3 part -0.35 part, can enhance the free radical scavenging ability of body Skin Cell, especially
It is nano zinc powder when brown alga extract is used together, and oxidation resistance and free radical scavenging ability effect to skin are all
With certain facilitation.By using Algisium C, when brown alga extract is used together,
Moistening effect is more preferable, can increase product silk smooth felling, and can delaying skin dried-up time.By using dimethyl-silicon alkanol,
When brown alga extract is used together, certain removing or inhibiting effect can also be played to the wrinkle of skin, so as to
The aging of enough delaying skins.By adding beeswax, other than it can play the role of certain nutritional supplementation to skin, additionally it is possible to have
There is certain bacteriostasis, the storage time of skin care compositions can be extended.
For example, the CB Number of Algisium C are CB8962322.For another example, dimethyl-silicon alkanol is
T-butyldimethyl silane alcohol, No. CAS is 18173-64-3.For another example, the average grain diameter of nano zinc powder is received for 40 nanometers~80
Rice.
In one embodiment, in the skin care compositions based on brown alga extract, the Algisium C
Mass parts are 37 parts -39 parts, and the mass parts of the dimethyl-silicon alkanol are 36 parts -38 parts, the mass parts of the brown alga extract
It it is 10 parts -11.5 parts, the mass parts of the nano zinc powder are 0.32 part -0.34 part, and the mass parts of the nucleoprotamine are 2.7
The mass parts of -2.9 parts of part, the beeswax are 2.5 parts -2.8 parts, and the mass parts of the water are 53 parts -53.5 parts.In this way, preparing
The obtained skin care compositions based on brown alga extract has better anti-oxidant, anti-aging effects, have better moisturizing and
Water lock effect further can mention certain nutritional supplementation to skin and act on, be conducive to repair damaged cell.It can be to skin
The wrinkle of skin plays removing or inhibiting effect preferably, so as to the aging of further delaying skin.
In one embodiment, in the skin care compositions based on brown alga extract, the Algisium C
Mass parts are 38 parts, and the mass parts of the dimethyl-silicon alkanol are 38 parts, and the mass parts of the brown alga extract are 10.8 parts, institute
The mass parts for stating nano zinc powder are 0.33 part, and the mass parts of the nucleoprotamine are 2.8 parts, and the mass parts of the beeswax are 2.7
Part, the mass parts of the water are 53.2 parts.In this way, the skin care compositions based on brown alga extract being prepared has preferably
Anti-oxidant, anti-aging effects have better moisturizing and water lock effect, further can mention certain nutrition to skin and mend
It uses use as, is conducive to repair damaged cell.Removing or inhibiting effect preferably can be played to the wrinkle of skin, so as to
The aging of enough further delaying skins.
In one embodiment, the skin care compositions based on brown alga extract further includes emulsifier.In this way, can add as needed
Add the additive amount of emulsifier by skin care compositions as watery, gel or membranaceous.For another example, the mass parts of the emulsifier are
0.5 part -1 part.For another example, the emulsifier is Sodium Polyacrylate.Through applicants have found that, the skincare composition being so prepared
Object using effect is relatively preferable.
In one embodiment, the mass ratio of the Algisium C and the dimethyl-silicon alkanol is 1：1.
In this way, by using Algisium C, when brown alga extract is used together, moistening effect is more preferable,
Product silk smooth felling can be increased, and can delaying skin dried-up time, additionally it is possible to the wrinkle of skin is played preferably remove or
Inhibiting effect, so as to the aging of delaying skin.
In one embodiment, the skin care compositions based on brown alga extract further includes leucine, valine and isoleucine.Such as
This enables to the anti-aging of skin care compositions to imitate by adding leucine, valine and isoleucine in skin care compositions
Fruit is more preferable.Preferably, the mass parts of the leucine are 0.05 part -0.15 part.It is furthermore preferred that the mass parts of the leucine are
0.09 part -0.12 part.It is furthermore preferred that the mass parts of the leucine are 0.01 part.Preferably, the mass parts of the valine are
0.12 part -0.18 part.It is furthermore preferred that the mass parts of the valine are 0.13 part -0.15 part.It is furthermore preferred that the valine
Mass parts be 0.14 part.Preferably, the mass parts of the isoleucine are 0.08 part -0.15 part.Preferably, the different bright ammonia
The mass parts of acid are 0.08 part -0.1 part.It is furthermore preferred that the mass parts of the isoleucine are 0.09 part.In one embodiment, institute
The mass ratio for stating leucine, the valine and the isoleucine is 1：1.4：0.9.In this way, through applicants have found that, such as
The skin care compositions anti-aging effects that this is prepared are more preferable.
The present invention also provides a kind of preparation method of brown alga extract, fucoidin etc. in brown alga extract is controlled with this
The content of active constituent, and the quality of brown alga extract is controlled, safer it can be effectively applied to skincare composition
In object.For another example, the brown alga extract in the skin care compositions based on brown alga extract described in any embodiment as above uses
The preparation method of the brown alga extract is prepared.For another example, the brown alga extract derives from kelp.For another example, the brown alga
The preparation method of extract includes the following steps：
S110：Collect fresh brown alga；
For example, the brown alga is kelp or sargassum thunbergii.In the present embodiment, the brown alga is kelp.For example, fresh is brown
Algae refers to 0.1 hour~48 hours after acquisition brown algas.Preferably, fresh brown alga refers to 0.1 hour~24 hours after acquisition
Brown alga.In this way, convenient for improving the content of fucoidin in the brown alga extract being subsequently prepared.
S120：The brown alga is crushed into operation, obtains brown alga powder；
For example, the brown alga is operated by low-temperature grinding, brown alga powder is obtained；For another example, at 2 degrees Celsius~10 degrees Celsius
At a temperature of operation is crushed to fresh brown alga.For another example, the average grain diameter of brown alga powder is 0.4 millimeter~1.2 millimeters, preferably
, the average grain diameter of brown alga powder is 0.5 millimeter~0.8 millimeter, it is furthermore preferred that the average grain diameter of brown alga powder is 0.6 millimeter~0.7
Millimeter.It so, it is possible to further increase the content of fucoidin in the brown alga extract being subsequently prepared.
S130：The brown alga powder is added in the ethanol solution of sodium hydroxide and extracts operation, obtains mixed extract；
Operation is extracted by the way that the brown alga powder to be added in the ethanol solution of sodium hydroxide, obtains mixed extract,
In order to which the fucose in brown alga is extracted.It is to be particularly noted that being carried only by ethyl alcohol relative to traditional
The fucoidin in brown alga is taken, the fucoidin in brown alga is extracted by using the ethanol solution of sodium hydroxide, it can be into one
Step improves the content of fucoidin in the brown alga extract being subsequently prepared.For example, the second that the ethyl alcohol is a concentration of 45%
Alcoholic solution.For another example, in the ethanol solution of the sodium hydroxide, the sodium hydroxide and a concentration of 45% ethanol solution
Mass volume ratio is (0.25 gram~0.45 gram)：1L.Preferably, the sodium hydroxide and a concentration of 45% ethanol solution
Mass volume ratio be (0.3 gram~0.35 gram)：1L.It is furthermore preferred that the sodium hydroxide and a concentration of 45% ethyl alcohol
The mass volume ratio of solution is 0.32 gram：1L.It so, it is possible the basis of the content of fucoidin in ensureing brown alga extract
On, additionally it is possible to the usage amount of ethyl alcohol is reduced, so that the manufacturing cost of brown alga extract is greatly reduced.Especially needed explanation
It is that traditional brown alga extract typically uses the ethyl alcohol of the high concentration of absolute ethyl alcohol or 75% or more to extract in brown alga
Fucoidin, but pass through applicants have found that, the ethyl alcohol cost using the high concentration of absolute ethyl alcohol or 75% or more is very big.For
This, by applicants have found that, by traditional ethyl alcohol extraction addition sodium hydroxide can have fabulous extraction to imitate
Fruit, and the usage amount of ethyl alcohol can also be reduced, so as to substantially save production cost.Especially solid-liquid ratio with tradition only
Using only the solid-liquid ratio phase of the ethyl alcohol of 75% or more high concentration meanwhile, it is capable on the basis for ensureing that ethyl alcohol usage amount is greatly reduced
On, ensure the content and yield of fucoidin in brown alga extract.For another example, the ethyl alcohol of the brown alga powder and the sodium hydroxide is molten
The solid-liquid ratio of liquid is 1：50.
In one embodiment, for the extraction operation at 65 DEG C~75 DEG C, supersonic frequency is to extract 65min under 50kHz~70kHz
~90min, in this way, through applicants have found that, enable to the yield of fucoidin in brown alga extract 4% or more.It is excellent
Choosing, the extraction operation at 73 DEG C, supersonic frequency be extract 85min under 68kHz, in this way, through applicants have found that, can
So that the yield of fucoidin is 6.5% or more in brown alga extract.
S140：The mixed extract is filtered operation, obtains filtered fluid；
In the present embodiment, the mixed extract is subjected to the filter operation using multilayer gauze.For another example, using three layers
Gauze~six layer gauze is filtered operation.Preferably, it is filtered operation using three layers of gauze.
S150：The filtered fluid is subjected to concentration operation, obtains concentrate；
For example, carrying out the concentration operation using revolving evaporimeter.For another example, the volume of the concentrate and the filtered fluid
Than being 1：10, i.e., by ten times of the filtered fluid volume concentration.In this way, facilitating subsequent extraction operation, additionally it is possible to reduce or go
Except the amount of ethyl alcohol in concentrate.
In one embodiment, before carrying out concentration operation to the filtered fluid, also the filtered fluid is carried out using filter membrane
Filtering, obtains filter membrane filtrate, and gained filter membrane filtrate is carried out concentration operation, obtains concentrate；In this way, to remove in extract liquor
Most of protein.Preferably, the molecular weight of the filter membrane is 10000 dalton.It so, it is possible in the removal extract liquor built up
Most of protein.
S160：Operation is dried in the concentrate, obtains brown alga extract.
For example, operation is dried using Rotary Evaporators in the filtrate, brown alga extract is obtained.Preferably, described
Drying process is that freeze-drying operates.
The preparation method of above-mentioned brown alga extract extracts the fucose in brown alga relative to traditional only by ethyl alcohol
Glue, can be with fabulous extraction effect by the addition sodium hydroxide in traditional ethyl alcohol extraction, and can also reduce second
The usage amount of alcohol, so as to substantially save production cost.75% or more height is especially only used only with tradition in solid-liquid ratio
The solid-liquid ratio of the ethyl alcohol of concentration is identical, can ensure in brown alga extract on the basis of ensureing that ethyl alcohol usage amount is greatly reduced
The content and yield of fucoidin.
In one embodiment, the skin care compositions based on brown alga extract further includes peach (PRUNUSPERSICA) resin
0.51 part -0.54 part of extract and 0.52 part -0.55 part of reticulin of hydrolysis；In this way, by selecting peach resin extract 0.51
- 0.54 part of part, wherein containing polysaccharide and a small amount of protein etc., when 0.51 part -0.54 part of peach resin extract and brown alga are extracted
When object is used together, the film forming moistening effect of the skin care compositions based on brown alga extract can be further increased, additionally it is possible to have
There is certain antiperspirant effect, 0.52 part -0.55 part of reticulin (hydrolyzed reticulin) is hydrolyzed by selection, it can
After so that the skin care compositions based on brown alga extract is adsorbed in skin film forming, there is certain repair to impaired cutin,
When especially 0.51 part -0.54 part of peach resin extract and 0.52 part -0.55 part of reticulin of hydrolysis are used in conjunction with, in film forming
On the basis of, it is more preferable to the repairing effect of skin keratin.Preferably, the mass parts of peach resin extract are 0.51 part -0.53 part, water
The mass parts for solving reticulin are 0.53 part -0.54 part；It is furthermore preferred that the mass parts of peach resin extract are 0.52 part, hydrolysis
The mass parts of reticulin are 0.53 part, so, it is possible the film forming for further increasing the skin care compositions based on brown alga extract
Moistening effect after skin care compositions can be made to be adsorbed in skin film forming, has better repair to impaired cutin.
In one embodiment, the skin care compositions based on brown alga extract further include 0.00001 part of tridecanoic peptide -1~
0.00005 part and 0.00002 part~0.00007 part of decapeptide -4, by the way that decapeptide -4 0.00002 part~0.00007 is added simultaneously
0.00001 part~0.00005 part of part and tridecanoic peptide -1 have preferable whitening anti-wrinkling effect, additionally it is possible to improve skin surface
Speckle has preferable improvement effect, through experiment, to chloasma effective percentage 25% or more to chloasma.Preferably, ten three
The mass parts of peptide -1 are 0.000011 part~0.000046 part, and the mass parts of decapeptide -4 are 0.000041 part~0.000045 part；
Preferably, the mass parts of tridecanoic peptide -1 are 0.000036 part, and the mass parts of decapeptide -4 are 0.000042 part, in this way, with preferable
Whitening anti-wrinkling effect, can further improve the speckle of skin surface, to chloasma have preferable improvement effect.
It further include clove bud oil 0.5 part~1.5 in one embodiment, in the skin care compositions based on brown alga extract
Part, for another example, the mass parts of the clove bud oil are 0.9 part~1.2 parts, and for another example, the mass parts of the clove bud oil are 1.1
Part, in this way, by the way that 0.5 part~1.5 parts of clove bud oil is added, on the one hand, the skincare composition based on brown alga extract can be made
It can make face cream especially when being used in conjunction with cloves alabastrum extract with more rich cloves bud fragrance in object
In cloves bud fragrance it is more strong.On the other hand, clove bud oil also has certain moisturizing, fungistatic effect, Neng Goujin
One step enhances the moistening effect of the skin care compositions based on brown alga extract, can further be played to the reparation of skin ulcer
Certain facilitation.
Further include in one embodiment, in the skin care compositions based on brown alga extract 2 parts of RADIX PEUCEDANI extract~
2.8 parts, praeruptorin A can play the calcium balance in human skin cell certain maintenance in RADIX PEUCEDANI extract
Effect, it is better especially when being combined with brown alga extract.Intracellular Ca2+ is adjusted by many factors, wherein cell
Film ATP enzyme plays a major role in being arranged outside cellular calcium, is one of the important mechanisms for maintaining intracellular calcium homeostasis.By the way that white flower is added
2 parts~2.8 parts of Radix Peucedani extract when being combined with brown alga extract, can preferably inhibit calcium in Skin Cell caused by KCl
Increase, increases Skin Cell film and mitochondria Na+, K+ATP enzyme and mitochondria Ca2+, Mg2+The activity of ATP enzyme passes through enhancing
The activity of ATP enzyme maintains the normal physiological function of Skin Cell, has so as to accelerate the discharge of the calcium in Skin Cell
Certain anti-aging effects are conducive to the health of skin.
In one embodiment, the skin care compositions based on brown alga extract further include 0.5 part of epidermal stem cells active constituent~
1.2 part.By 0.5 part~1.2 parts of epidermal stem cells active constituent of addition, reparation can be played the role of to the cell of damage,
The cell metabolism function of Skin Cell especially epidermal cell can be enhanced, enhance cutaneous immunisation power, reduce the appearance of erythema etc.,
Also there is anti-aging and other effects.When especially epidermal stem cells active constituent is used in conjunction with brown alga extract, to skin
Repairing has synergistic effect, can further cutaneous immunisation power, inhibiting effect is played to the inflammation of skin to a certain extent, also
The appearance of erythema etc. can be reduced.Preferably, the mass parts of epidermal stem cells active constituent are 0.8 part~1.1 parts, more preferably
, the mass parts of epidermal stem cells active constituent are 0.95 part, so, it is possible further cutaneous immunisation power, to a certain extent
Inhibiting effect is played to the inflammation of skin, additionally it is possible to reduce the appearance of erythema etc..
The above-mentioned skin care compositions based on brown alga extract, using brown alga extract as main active, brown alga extract
In contain fucoidin, there is preferable anti-oxidant, anti-aging effects, filler of the fucoidin as cell wall, general
When it is applied in skin care compositions, also there is preferable moisturizing and water lock effect.Especially brown alga extract and nucleoprotamine
When being used together, certain nutritional supplementation effect can be mentioned to skin, is conducive to repair damaged cell.By adding Nano-Zinc
The mass parts of powder, the nano zinc powder are 0.3 part -0.35 part, can enhance the free radical scavenging ability of body Skin Cell, especially
It is nano zinc powder when brown alga extract is used together, and oxidation resistance and free radical scavenging ability effect to skin are all
With certain facilitation.By using Algisium C, when brown alga extract is used together,
Moistening effect is more preferable, can increase product silk smooth felling, and can delaying skin dried-up time.By using dimethyl-silicon alkanol,
When brown alga extract is used together, certain removing or inhibiting effect can also be played to the wrinkle of skin, so as to
The aging of enough delaying skins.By adding beeswax, other than it can play the role of certain nutritional supplementation to skin, additionally it is possible to have
There is certain bacteriostasis, the storage time of skin care compositions can be extended.
In order to further illustrate the above-mentioned skin care compositions based on brown alga extract, continues with and come in conjunction with specific embodiments
It is explained.
Embodiment 1：A kind of skin care compositions based on brown alga extract, including：Algisium C 38
Part, 38 parts of dimethyl-silicon alkanol, 10.8 parts of brown alga extract, 0.33 part of nano zinc powder .8 parts of Protamine-2,2.7 parts of beeswax,
53.2 parts of water.
Embodiment 2：A kind of skin care compositions based on brown alga extract, including：Algisium C 35
Part, 35 parts of dimethyl-silicon alkanol, 12 parts of brown alga extract, 0.35 part of nano zinc powder .8 parts of Protamine-2,2.7 parts of beeswax, water
53.2 parts.
Comparative example 1：Skin care compositions includes：38 parts of Algisium C, 38 parts of dimethyl-silicon alkanol, receives
0.33 part of zinc powder of rice .8 parts of Protamine-2,2.7 parts of beeswax, 53.2 parts of water.
Comparative example 2：Skin care compositions includes:38 parts of Algisium C, 38 parts of dimethyl-silicon alkanol are brown
10.8 parts of algae extract, 53.2 parts of water.
Comparative example 3：Skin care compositions includes：10.8 parts of brown alga extract, 150 parts of water.
Comparative example 4：Skin care compositions includes：38 parts of Algisium C, 38 parts of dimethyl-silicon alkanol, water
53.2 parts.
The skin care compositions of embodiment 1, embodiment 2, comparative example 1 to comparative example 4 is carried out to the survey of free radical scavenging ability
It is fixed, that is, remove DDPH (DPPH.free radical, C18H12N5O6) ability measurement, test result is as follows：
Table 1 removes the measurement result of DDPH abilities
| Embodiment | Clearance rate |
| Embodiment 1 | 20.2% |
| Embodiment 2 | 18.2% |
| Comparative example 1 | 2.1% |
| Comparative example 2 | 12.1% |
| Comparative example 3 | 10.7% |
| Comparative example 4 | 1.7% |
As seen from the above, the skin care based on brown alga extract provided compared to comparative example, embodiment 1 and embodiment 2
Composition has preferable radicals scavenging effect, removes DDPH abilities 18.2% or more, significantly larger than only uses brown alga
The 10.7% of the comparative example 3 of extract, while also above the comparative example 2 of unused nano zinc powder, beeswax, nucleoprotamine, showing
Embodiment 1 and embodiment 2 have preferable free radical scavenging ability, to preferable by the mutual proportioning of each component
Antioxidant effect.
The skin care compositions of embodiment 1, embodiment 2, comparative example 1 to comparative example 4 is subjected to Fibroblasts in vitro proliferation
Ability detects, and subject cell is purchased from Beijing Biological Product Inst., be respectively adopted skin care compositions addition 5% in culture solution into
Row experiment, through experiment, the cell survival after the skin care compositions effect of embodiment 1 was 48 generations, and the skin care compositions of embodiment 2 is made
Cell survival after was 45 generations, and the cell survival after the skin care compositions effect of comparative example 1 is 38 generations, the skin care of comparative example 2
Cell survival after composition effect was 42 generations, and the cell survival after the skin care compositions effect of comparative example 3 is 40 generations, comparative example
Cell survival after 4 skin care compositions effect was 36 generations.
It can be seen that the skin care compositions based on brown alga extract of embodiment 1 and embodiment 2 has preferable anti-aging
Effect, the anti-aging effects of embodiment 1 are best.
The above-mentioned skin care compositions based on brown alga extract, using brown alga extract as main active, brown alga extract
In contain fucoidin, there is preferable anti-oxidant, anti-aging effects, filler of the fucoidin as cell wall, general
When it is applied in skin care compositions, also there is preferable moisturizing and water lock effect.Especially brown alga extract and nucleoprotamine
When being used together, certain nutritional supplementation effect can be mentioned to skin, is conducive to repair damaged cell.By adding Nano-Zinc
The mass parts of powder, the nano zinc powder are 0.3 part -0.35 part, can enhance the free radical scavenging ability of body Skin Cell, especially
It is nano zinc powder when brown alga extract is used together, and oxidation resistance and free radical scavenging ability effect to skin are all
With certain facilitation.By using Algisium C, when brown alga extract is used together,
Moistening effect is more preferable, can increase product silk smooth felling, and can delaying skin dried-up time.By using dimethyl-silicon alkanol,
When brown alga extract is used together, certain removing or inhibiting effect can also be played to the wrinkle of skin, so as to
The aging of enough delaying skins.By adding beeswax, other than it can play the role of certain nutritional supplementation to skin, additionally it is possible to have
There is certain bacteriostasis, the storage time of skin care compositions can be extended.
The present invention also provides a kind of applicator system, the applicator system includes the skin care group described in any embodiment as above
Close object.For another example, the applicator system includes the skin care compositions based on brown alga extract described in any embodiment as above.Again
Such as, the applicator system includes control painting pen and skin care compositions, and the skin care compositions is described in any embodiment as above
The skin care compositions based on brown alga extract.The painting pen includes cylinder, Massage Department, spring, ball and supports bar, described
Cylinder offers accommodating cavity, and the accommodating cavity is equipped with the skin care compositions described in any embodiment as above, in other words, described
Skin care compositions is placed in the accommodating cavity.The Massage Department connects the cylinder, and the Massage Department has hollow structure, institute
It states Massage Department and one end of the cylinder is provided with fixed link, end of the Massage Department far from the cylinder offers out sample
Hole, the ball part are placed in the sample outlet hole, the first end for supporting bar connects the ball, the bar that supports
Second end connects the first end of the spring, and the second end of the spring connects the fixed link, and the ball is used for described
Ball is supported the bar compression spring to open the sample outlet hole by described in being driven when external pressure, and the ball is additionally operable to
External pressure closes the sample outlet hole when disappearing under the action of the restoring force of the spring.In this way, applicator system described above,
The skin care compositions can preferably be smeared.For another example, the shape adaptation of the sample outlet hole is in the shape of the ball.For another example,
The cylinder is spirally connected the Massage Department.
In order to preferably install the spring, in an embodiment, storage tank is provided in the fixed link, the spring
Second end is placed in the storage tank, and for another example, the second end of the spring is abutted with the bottom wall of the storage tank.For another example, institute
The second end of spring is stated in the storage tank, for another example, the second end of the spring is embedded in the storage tank and institute
The second end for stating spring is abutted with the bottom wall of the storage tank.For another example, the bar that supports is provided with mounting groove, and the of the spring
One end is placed in the mounting groove, and for another example, the first end of the spring is abutted with the bottom wall of the mounting groove.For another example, described
The first end of spring is in the mounting groove, and for another example, the first end of the spring is in the mounting groove and described
The first end of spring is abutted with the bottom wall of the mounting groove, so, it is possible preferably to install the spring.
In order to enable the ball preferably to close and open the sample outlet hole, in an embodiment, it is described go out sample
Hole has circular cross-section, and for another example, the sample outlet hole has arc shaped inside wall, and for another example, the sample outlet hole is along close to the cylinder
Direction gradually broadens, and for another example, the diameter in the section at the most narrow place of the sample outlet hole is less than the diameter of the ball, so, it is possible to make
The ball preferably can close and open the sample outlet hole.
In order to play preferable massage effect, in an embodiment, the lateral wall of the Massage Department is provided with burr, again
Such as, the lateral wall of the Massage Department is provided with several burrs, and for another example, several burrs are circularly and evenly distributed in the massage
On the lateral wall in portion, it so, it is possible to make the Massage Department that can also play preferable massage effect.
It is understood that during ball use, surface easily grows bacterium.In one embodiment, the ball surface
It is provided with antimicrobial coating, so, it is possible that antimicrobial coating is arranged on the ball surface, it can be inhibited during ball use
The growth and breeding of surface bacteria.For another example, the antimicrobial coating includes following ingredient：Nano titanium powder and polyureas-resinous copolymeric siloxane
Object, wherein the mass ratio of the nano titanium powder and polyureas-resinous copolymeric siloxane object is 1：(3~4.5), it is preferred that the nano-titanium
The mass ratio of powder and polyureas-resinous copolymeric siloxane object is 1：(3.9~4.2), it is furthermore preferred that the nano titanium powder and polyureas-silicon tree
The mass ratio of resin copolymer is 1：4.1, it so, it is possible the growth for preferably inhibiting ball surface bacteria during ball use
And breeding.
In order to enable the ball preferably to smear the reparation liquid, an embodiment when the sample outlet hole is opened
In, the first end for supporting bar offers rolling groove, and the ball part is placed in the rolling groove, and the ball exists
It can be rolled in the rolling groove, in this way, compressing the spring when the ball is by external pressure so that ball is to close to institute
The direction displacement for stating cylinder, to open the sample outlet hole so that flow to the described of the hollow structure of the Massage Department in accommodating cavity
Skin care compositions is flowed out by the sample outlet hole, then by rolling the ball, can preferably smear the reparation liquid.Again
Such as, when the ball opens the sample outlet hole, the ball can roll.
In order to preferably preserve skin care compositions, the active ingredient of skin care compositions is avoided to inactivate, it is described in an embodiment
The lateral wall of cylinder, which is sticked, thermoelectric module, and thermoelectric module is used to provide refrigerating function to the cylinder, in this way, passing through heat
Electric cooling piece can make accommodating cavity maintain lower temperature.For another example, the thermoelectric module is also referred to as semiconductor chilling plate.
For another example, the cylinder is additionally provided with power module, and the power module connects the thermoelectric module.For another example, the thermoelectricity system
The cold side far from the accommodating cavity is also sticked and has heat dissipation graphite film, in this way, can make thermoelectric cooling by the graphite film that radiates
The heat of the heating side of piece is quickly scattered away, to further increase refrigeration effect of the thermoelectric module to accommodating cavity.For another example, institute
The thickness for stating heat dissipation graphite film is 0.05 millimeter~3 millimeters, it is preferred that the thickness of the heat dissipation graphite film is 0.8 millimeter~1.4
Millimeter so, it is possible the heat for the heating side for making thermoelectric module it is furthermore preferred that the thickness of the heat dissipation graphite film is 1.2 millimeters
Amount is quickly scattered away, and the refrigeration effect for further increasing thermoelectric module to accommodating cavity is so, it is possible.It so, it is possible preferably
Skin care compositions is preserved, the active ingredient inactivation of skin care compositions is slowed down.For another example, the lateral wall of the cylinder is sticked the thermoelectricity
Cooling piece.It so, it is possible preferably to preserve skin care compositions, the active ingredient of skin care compositions avoided to inactivate.
The above-mentioned skin care compositions based on brown alga extract, using brown alga extract as main active, brown alga extract
In contain fucoidin, there is preferable anti-oxidant, anti-aging effects, filler of the fucoidin as cell wall, general
When it is applied in skin care compositions, also there is preferable moisturizing and water lock effect.Especially brown alga extract and nucleoprotamine
When being used together, certain nutritional supplementation effect can be mentioned to skin, is conducive to repair damaged cell.By adding Nano-Zinc
The mass parts of powder, the nano zinc powder are 0.3 part -0.35 part, can enhance the free radical scavenging ability of body Skin Cell, especially
It is nano zinc powder when brown alga extract is used together, and oxidation resistance and free radical scavenging ability effect to skin are all
With certain facilitation.By using Algisium C, when brown alga extract is used together,
Moistening effect is more preferable, can increase product silk smooth felling, and can delaying skin dried-up time.By using dimethyl-silicon alkanol,
When brown alga extract is used together, certain removing or inhibiting effect can also be played to the wrinkle of skin, so as to
The aging of enough delaying skins.By adding beeswax, other than it can play the role of certain nutritional supplementation to skin, additionally it is possible to have
There is certain bacteriostasis, the storage time of skin care compositions can be extended.
It should be noted that the mass parts can be understood as gram, milligram, kilogram, jin, kilogram, pound, ton etc..With gram
For, for example, 1 mass parts can be 0.001g, 0.01g, 0.02g, 0.05g, 0.1g, 0.2g, 0.5g, 1g, 2g, 3g, 4g,
5g, 10g, 15g, 20g, 30g, 50g, 80g, 100g, 500g, 1000g, 5000g, 10000g or 50000g etc., and it is without being limited thereto.
And so on.
Each technical characteristic of embodiment described above can be combined arbitrarily, to keep description succinct, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, it is all considered to be the range of this specification record.
Several embodiments of the invention above described embodiment only expresses, the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the protection of the present invention
Range.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (10)
1. a kind of skin care compositions based on brown alga extract, which is characterized in that including Algisium C, two
Methyl-monosilane alcohol, brown alga extract, nano zinc powder, nucleoprotamine, beeswax and water, the Algisium C
Mass parts are 35 parts -40 parts, and the mass parts of the dimethyl-silicon alkanol are 35 parts -40 parts, the mass parts of the brown alga extract
It it is 9 parts -12 parts, the mass parts of the nano zinc powder are 0.3 part -0.35 part, and the mass parts of the nucleoprotamine are 2.5 part -3.5
Part, the mass parts of the beeswax are 2 parts -4 parts, and the mass parts of the water are 50 parts -55 parts.
2. the skin care compositions according to claim 1 based on brown alga extract, which is characterized in that further include emulsifier.
3. the skin care compositions according to claim 2 based on brown alga extract, which is characterized in that the matter of the emulsifier
It is 0.5 part -1 part to measure part.
4. the skin care compositions according to claim 2 based on brown alga extract, which is characterized in that the emulsifier is poly-
Sodium acrylate.
5. the skin care compositions according to claim 1 based on brown alga extract, which is characterized in that the methyl-monosilane alcohol
The mass ratio of mannuronic acid ester and the dimethyl-silicon alkanol is 1：1.
6. the skin care compositions according to claim 1 based on brown alga extract, which is characterized in that further include leucine,
Valine and isoleucine.
7. the skin care compositions according to claim 6 based on brown alga extract, which is characterized in that the matter of the leucine
It is 0.05 part -0.15 part to measure part.
8. the skin care compositions according to claim 6 based on brown alga extract, which is characterized in that the matter of the valine
It is 0.12 part -0.18 part to measure part.
9. the skin care compositions according to claim 6 based on brown alga extract, which is characterized in that the isoleucine
Mass parts are 0.08 part -0.15 part.
10. the skin care compositions according to claim 6 based on brown alga extract, which is characterized in that the leucine, institute
The mass ratio for stating valine and the isoleucine is 1：1.4：0.9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810355784.8A CN108309834A (en) | 2018-04-19 | 2018-04-19 | Skin care compositions based on brown alga extract |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810355784.8A CN108309834A (en) | 2018-04-19 | 2018-04-19 | Skin care compositions based on brown alga extract |
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| Publication Number | Publication Date |
|---|---|
| CN108309834A true CN108309834A (en) | 2018-07-24 |
Family
ID=62894461
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810355784.8A Withdrawn CN108309834A (en) | 2018-04-19 | 2018-04-19 | Skin care compositions based on brown alga extract |
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| CN (1) | CN108309834A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111728903A (en) * | 2019-03-25 | 2020-10-02 | 林载钐 | Injection and cosmetic composition containing lemon balm extract as active ingredient |
| CN112402322A (en) * | 2020-11-30 | 2021-02-26 | 黄丹 | Facial mask liquid capable of promoting expression of aquaporins AQP3 and AQP9 |
| CN112516016A (en) * | 2020-11-30 | 2021-03-19 | 黄丹 | Traditional Chinese medicine composition capable of promoting expression of aquaporins AQP3 and AQP9 in facial mask liquid |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1259043A (en) * | 1997-04-04 | 2000-07-05 | 布茨公司 | Cosmetic and/or dermatological composition containing a derivative of methylated silanol and a derivative of hydrolysed plant protein |
| CN105377232A (en) * | 2013-04-12 | 2016-03-02 | 圣地亚哥大学 | Antioxidant extract from brown macroalgae and method for obtaining same |
| CN106031709A (en) * | 2015-03-20 | 2016-10-19 | 上海辉文生物技术股份有限公司 | Milt DNA-NA, protamine extract and preparing method thereof |
-
2018
- 2018-04-19 CN CN201810355784.8A patent/CN108309834A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1259043A (en) * | 1997-04-04 | 2000-07-05 | 布茨公司 | Cosmetic and/or dermatological composition containing a derivative of methylated silanol and a derivative of hydrolysed plant protein |
| CN105377232A (en) * | 2013-04-12 | 2016-03-02 | 圣地亚哥大学 | Antioxidant extract from brown macroalgae and method for obtaining same |
| CN106031709A (en) * | 2015-03-20 | 2016-10-19 | 上海辉文生物技术股份有限公司 | Milt DNA-NA, protamine extract and preparing method thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111728903A (en) * | 2019-03-25 | 2020-10-02 | 林载钐 | Injection and cosmetic composition containing lemon balm extract as active ingredient |
| CN111728903B (en) * | 2019-03-25 | 2022-11-01 | 林载钐 | Injection and cosmetic composition containing lemon balm extract as active ingredient |
| CN112402322A (en) * | 2020-11-30 | 2021-02-26 | 黄丹 | Facial mask liquid capable of promoting expression of aquaporins AQP3 and AQP9 |
| CN112516016A (en) * | 2020-11-30 | 2021-03-19 | 黄丹 | Traditional Chinese medicine composition capable of promoting expression of aquaporins AQP3 and AQP9 in facial mask liquid |
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