CN108295245A - Increase bone density medicine and capsule preparation method thereof - Google Patents
Increase bone density medicine and capsule preparation method thereof Download PDFInfo
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- CN108295245A CN108295245A CN201810319379.0A CN201810319379A CN108295245A CN 108295245 A CN108295245 A CN 108295245A CN 201810319379 A CN201810319379 A CN 201810319379A CN 108295245 A CN108295245 A CN 108295245A
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- 230000037182 bone density Effects 0.000 title claims abstract description 29
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- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 36
- 102000008186 Collagen Human genes 0.000 claims abstract description 22
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- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
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- A61K38/00—Medicinal preparations containing peptides
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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Abstract
The present invention discloses a kind of increase bone density medicine and its capsule preparation method thereof, owner control the drug use in osteopathy field of osteoporosis, include the raw material of following parts by weight：150 250 parts of calcium carbonate, 70 110 parts of D aminoglucose hydrochlorides, 70 100 parts of collagen, 40 80 parts of the rhizome of davallia, 40 80 parts of the root of bidentate achyranthes, 40 80 parts of Ramulus Taxilli, 30 60 parts of cortex acanthopanacis, 30 60 parts of rhizoma cibotii, 20 50 parts of rhizoma homalonemae, 20 50 parts of Caulis Spatholobi.This medicine both using nourishing liver and kidney, strengthening the muscles and bones Chinese medicine solid protection kidney deficiency this, consolidate strong member, promote the raw bone of reconstruction, again bone necessity composition, supplement osteotrophy are made using offers such as natural calcium source, collagens, to reach the bone density that increases sharply, prevent and improve osteoporosis.
Description
Technical field
The present invention relates to a kind of drug use in osteopathy curing mainly osteoporosis, more particularly to a kind of increase bone density medicine and capsule
Preparation method.
Background technology
Osteoporosis be one kind characterized by Low BMD and bone tissue Microstructure Fracture, cause sclerotin brittleness increase and be easy to
The systemic bone metabolic disease of fracture.This disease is common in the elderly, but each period at age can fall ill.Osteoporosis can be divided into
Primary and secondary two class.Primary osteoporosis is meant not with other illness for causing this disease；Secondary osteoporosis is then
It is that the bone tissue amount caused by various systemic or endocrine metabolism disease is reduced.In addition, can also be divided by happening part
Limitation or general hair property osteoporosis.
Uncomplicated osteoporosis itself, and the symptoms such as without pain, also without signs such as deformities.This disease of early detection according to
By bone density inspection.Centrum x-ray plain film is later than bone density prompt extremely, but earlier than the prompt of symptom and sign.Usually do not knowing
Vertebral compression fracture occurs in unconsciously, also can induce vertebral fracture because of cough, sneezing, microtrauma etc..Fresh vertebral fracture
Several weeks in, there is local pain, percussion pain occurs in sign., there is hunchback in multiple Vertebral Compression persons, and height becomes short.Non- centrum
When fracture, pain and deformity performance are more serious.
Currently, osteoporosis mostly uses drug therapy, cure rate is low, recurrence is easy after healing, and be frequently accompanied by secondary work
With patent 201510560675.6 discloses a kind of drug for treating osteoporosis, is made of the bulk pharmaceutical chemicals of following parts by weight：Tortoise
Plate 5~9, small lycopod 4~7, sheep hinge 4~8, false nettleleaf pepper herb 4~7, creeping psychotria branchlet and leaf 4~8, garden balsam root 5~8, color wood maple 6~9, Morinda offcinalis How
Its 6~9, Sambucus thunbergiana 7~9, Aralia wood 6~9, snow red 2~5, laciniate blumea herb 6~9, pyrola 2~5, Chinese maple root 4~6, Sha Yuan
Son 2~4, thunderclap water plant 4~6, canarium pimela 2~4, meadow fescue 7~9, above-mentioned raw materials medicine is soaked in water, filtrate of removing slag after decocting to obtain.
The prescription drug complicated component is taken for a long time with Effects of Bu Gu with side effect.
Invention content
The present invention provides a kind of increase bone density medicine and capsule preparation method thereof that long-time service is nontoxic, this medicine both utilizes taste
Filling liver kidney, strengthening the muscles and bones Chinese medicine solid protection kidney deficiency this, consolidate strong member, promote the raw bone of reconstruction, and use natural calcium source, collagen egg
It is white that offers is waited to make bone necessity composition, supplement osteotrophy, to reach the bone density that increases sharply, prevent and improve osteoporosis.
The present invention proposes a kind of increase bone density medicine, includes the raw material for including following parts by weight：Calcium carbonate 150-250
Part, 70-110 parts of D-Glucosamine Hydrochloride, 70-100 parts of collagen, 40-80 parts of the rhizome of davallia, 40-80 parts of the root of bidentate achyranthes, mulberry is posted
It is 40-80 parts raw, 30-60 parts of cortex acanthopanacis, 30-60 parts of rhizoma cibotii, 20-50 parts of rhizoma homalonemae, 20-50 parts of Caulis Spatholobi.
Preferably, further include 20-40 parts of big discrimination tongue fur.
It can glue capsule, tablet, electuary.
The present invention also provides a kind of capsule preparation method thereofs of above-mentioned increase bone density medicine, which is characterized in that including following
Step：
(A) it stocks up：According to parts by weight, 150-250 parts of calcium carbonate is weighed, 70-110 parts of D-Glucosamine Hydrochloride,
70-100 parts of collagen, 40-80 parts of the rhizome of davallia, 40-80 parts of the root of bidentate achyranthes, 40-80 parts of Ramulus Taxilli, 30-60 parts of cortex acanthopanacis, rhizoma cibotii
30-60 parts, 20-50 parts of rhizoma homalonemae, 20-50 parts of Caulis Spatholobi, 1-4 parts of magnesium stearate；
(B) dry granulation：The rhizome of davallia, the root of bidentate achyranthes, Ramulus Taxilli, cortex acanthopanacis, rhizoma cibotii, rhizoma homalonemae, Caulis Spatholobi are distinguished into dry method system
The particle that moisture content is no more than 5% is made in grain；The operation of dry granulation is：Each bulk pharmaceutical chemicals got ready are added into 3-5 times of weight respectively
70% ethanol water refluxing extraction 1-3 times, filtering, merging filtrate is evaporated, and solid content crushes, by rolling or open
Refining glue machines l-3 times, is pressed into the thin slice of required hardness, then be ground into particle with oscillating granulator；
(C) it mixes：By above-mentioned 7 made kind particle, 150-250 parts of calcium carbonate, D-Glucosamine Hydrochloride 70-110
Part, 70-100 parts of collagen, 1-4 parts of magnesium stearate are uniformly mixed, and particle to be filled is made；
(D) it fills：Capsule is filled, finished product is made.
Preferably, in described " A. stocks " step, 20-40 parts of big discrimination tongue fur is weighed by weight, and at " B. dry granulations "
It takes dry granulation method that particle is made in big discrimination tongue fur in step, then carries out subsequent mixing, filling step.
The capsule material is hypromellose.
The rhizome of davallia：With The strong bone of kidney tonifying, the effect of continues and hinders pain relieving.It is mainly used for lumbago due to the kidney deficiency, Hiccough and deaf, tooth pine
It is dynamic, falling winks frustrates, the diseases such as injured bone.
Ramulus Taxilli：With effect that filling liver kidney, strengthening tendons are active；It is mainly used for the diseases such as soreness and weakness of waist and knees, muscles and bones inability；
The root of bidentate achyranthes：Have effects that filling liver kidney, strengthening the bones and muscles；It is mainly used for soreness of waist and knee joint, the diseases such as muscles and bones inability；
Cortex acanthopanacis：Have effects that strengthen the bone, strong waist and knee, tonify the liver and kidney；It is mainly used for muscles and bones impotence, physically weak weak etc.
Disease；
Rhizoma cibotii：The effect of with wind-damp dispelling, filling liver kidney, strong waist and knee；Be mainly used for arthralgia pain due to rheumatism, soreness and weakness of waist and knees, lower limb without
Not solid etc. diseases of power, kidney deficiency；
Rhizoma homalonemae：Have effects that wind-damp dispelling, strenghthening bone；It is mainly used for arthralgia pain due to rheumatism, waist and knee crymodynia, contraction, muscle
The soft equal diseases of the atrophic debility of bones；
Caulis Spatholobi：With promoting blood circulation and stopping pain, the effect of relaxing tendons and activating collaterals, this product can promoting blood circulation, dredging meridian and relieving pain and blood-nourishing honor muscle,
For treatment passages through which vital energy circulates is unsmooth, channels is got along well disease common medicine, to treat arthralgia pain due to rheumatism, extremity numbness, apoplexy is numb in every limb, limbs
Paralysis, the deficiency of blood are unable to the extremity numbness etc. of nourishing the muscle and tendon.
The beneficial effects of the invention are as follows：Using the rhizome of davallia, Ramulus Taxilli, the root of bidentate achyranthes as monarch drug in a prescription, three has to be mended prescription of the present invention
The effect of liver kidney, strengthening the bones and muscles, to consolidate strong member, i.e. this congenital foundation of kidney tonifying, kidney storing essence, main bone gives birth to marrow, and kidney essense abundance is then
Marrow biochemistry is active, and bone obtains marrow and supports then strong, and monarch drug in a prescription is anti-curing osteoporosis, increases the basic of bone density；With slender acanthopanax
Skin, rhizoma cibotii be ministerial drug, the two have temperature compensation the benefits of, can strengthen the bone, strong waist and knee, wind-damp dispelling, also can temperature compensation nourishing the liver and kidney, main needle
It is presented with effective to the illness caused by liver kidney deficiency is lost such as muscles and bones impotence, weakness of limbs, monarch drug in a prescription consolidates, ministerial drug controls disease, Xiang Fuxiang
At.Using rhizoma homalonemae as adjuvant, have effects that wind-damp dispelling, strenghthening bone；To tools such as arthralgia pain due to rheumatism, waist and knee crymodynia, contractions
The wind-damp dispelling having had, pain of dispelling curative effect, especially suitable for the elderly's arthritis pain, osteoporosis；Using Caulis Spatholobi as priming, Caulis Spatholobi
With promoting blood circulation and stopping pain, relaxing tendons and activating collaterals, blood-nourishing honor muscle, the effect of, the extremity numbness etc. of nourishing the muscle and tendon is unable to for quadriplegia, the deficiency of blood,
The medicine be used for compatibility of the present invention, can priming uplink, relax degrading the channel, make the sensible whole body of drug effect, until liver kidney, lead to four limbs, make monarch drug in a prescription, minister
Medicine, adjuvant bring out the best in each other in effect, complement each other, and play a multiplier effect.Big discrimination tongue fur, which plays, promotes drug to inhale
Receive, promote the effect of drug effect.And calcium carbonate can provide calcium ion, increase the raw material of bon e formation, calcium ion deposition in bone matrix,
Hydroxyapatite crystal, the main component as bone mineral are formed with phosphorus；D-Glucosamine Hydrochloride can be human body Bones and joints
The natural constituent of middle glycoprotein has anti-osteoarthritis effect, can promote union promotive factor-Bones morphology that egg occurs
White secretion, makes mesenchymal cell be converted to chondroblast and osteoblast, promotes the formation of new bone, to close with bone is increased
The effect of degree and anti-osteoporosis；Collagen is the main component of cartilage, and reticular structure is constituted in bone, is responsible for clinging calcium
Matter maintains the toughness of bone, enhances bone density；D-Glucosamine Hydrochloride, collagen are the important of organic substrate bone trabecula in bone
Component part is the holder of inorganic rock salt deposition in bone will cause bone close if the reduction of collagen content makes it have no way of adhering to
The reduction of degree.This composition draws traditional Chinese medicine prevention osteoporosis while supplementing osteotrophy using natural calcium source, collagen
Essence, select it is nourishing liver and kidney, the product of strengthening the muscles and bones with solid protection kidney deficiency this, across-the-board regulation viscera function increases to reach
The purpose of osteoporosis is prevented and improved to bone density.The collaboration of this prescription compatibility, simplify efficiently, bone density can be effectively increased, is fast
Speed works.
Deficiency of kidney essence, marrow subtract bone it is withered be osteoporosis occur basic factor.Nutritional status is the master for influencing bone metabolism
It is to lead to a main cause of osteoporosis to want factor, calcium nutritional deficiency.In short, the present invention can use Chinese medicine innovation to match
5, filling liver kidney, strong waist and knee strengthens the bone, and the interior tune for anti-curing osteoporosis, increase bone density is basic；Again can with calcium carbonate,
D-Glucosamine Hydrochloride, collagen etc. supply calcium nutrition, so that the sclerotin that interior tune works is had sufficiently osteotrophy supplement, make
Growth has material base support, can rapidly grow, increase bone density.
Specific implementation mode
Embodiment 1
The present embodiment provides a kind of increase bone density medicines, include the raw material of following parts by weight：160 parts of calcium carbonate, D- ammonia
80 parts of base glucosamine salt hydrochlorate, 75 parts of collagen, 45 parts of the rhizome of davallia, 45 parts of the root of bidentate achyranthes, 45 parts of Ramulus Taxilli, 35 parts of cortex acanthopanacis, dog
35 parts of ridge, 25 parts of rhizoma homalonemae, 25 parts of Caulis Spatholobi.It can glue capsule, tablet, electuary.
The present embodiment provides a kind of capsule preparation method thereofs increasing bone density medicine, include the following steps：
(A) it stocks up：According to parts by weight, 160 parts of calcium carbonate, 80 parts of D-Glucosamine Hydrochloride, collagen are weighed
75 parts, 45 parts of the rhizome of davallia, 45 parts of the root of bidentate achyranthes, 45 parts of Ramulus Taxilli, 35 parts of cortex acanthopanacis, 35 parts of rhizoma cibotii, 25 parts of rhizoma homalonemae, Caulis Spatholobi 25
Part, 2 parts of magnesium stearate；
(B) dry granulation：The rhizome of davallia, the root of bidentate achyranthes, Ramulus Taxilli, cortex acanthopanacis, rhizoma cibotii, rhizoma homalonemae, Caulis Spatholobi are distinguished into dry method system
The particle that moisture content is no more than 5% is made in grain；The operation of dry granulation is：Each bulk pharmaceutical chemicals got ready are added 3-5 times respectively to weigh
70% ethanol water refluxing extraction of amount 1-3 times, filtering, merging filtrate are evaporated, and solid content crushes, by rolling or opening
Formula refining glue machines l-3 times, is pressed into the thin slice of required hardness, then be ground into particle with oscillating granulator.
(C) it mixes：By above-mentioned 7 made kind particle and calcium carbonate, D-Glucosamine Hydrochloride, the collagen egg got ready
In vain, magnesium stearate is uniformly mixed, and particle to be filled is made；
(D) it fills：Capsule is filled, finished product is made.
The capsule material is hypromellose.
Embodiment 2
The present embodiment provides a kind of increase bone density medicines, include the raw material of following parts by weight：200 parts of calcium carbonate, D- ammonia
90 parts of base glucosamine salt hydrochlorate, 85 parts of collagen, 60 parts of the rhizome of davallia, 60 parts of the root of bidentate achyranthes, 60 parts of Ramulus Taxilli, 45 parts of cortex acanthopanacis, dog
45 parts of ridge, 35 parts of rhizoma homalonemae, 35 parts of Caulis Spatholobi.It further include 30 parts of big discrimination tongue fur.It can glue capsule, tablet, electuary.
The present embodiment provides a kind of capsule preparation method thereofs increasing bone density medicine, include the following steps：
(A) it stocks up：According to parts by weight, 200 parts of calcium carbonate, 90 parts of D-Glucosamine Hydrochloride, collagen are weighed
85 parts, 60 parts of the rhizome of davallia, 60 parts of the root of bidentate achyranthes, 60 parts of Ramulus Taxilli, 45 parts of cortex acanthopanacis, 45 parts of rhizoma cibotii, 35 parts of rhizoma homalonemae, Caulis Spatholobi 35
Part, 3 parts of magnesium stearate；
(B) dry granulation：The rhizome of davallia, the root of bidentate achyranthes, Ramulus Taxilli, cortex acanthopanacis, rhizoma cibotii, rhizoma homalonemae, Caulis Spatholobi are distinguished into dry method system
The particle that moisture content is no more than 5% is made in grain；The operation of dry granulation is：Each bulk pharmaceutical chemicals got ready are added into 3-5 times of weight respectively
70% ethanol water refluxing extraction 1-3 times, filtering, merging filtrate is evaporated, and solid content crushes, by rolling or open
Refining glue machines l-3 times, is pressed into the thin slice of required hardness, then be ground into particle with oscillating granulator.
(C) it mixes：By above-mentioned 7 made kind particle and calcium carbonate, D-Glucosamine Hydrochloride, the collagen egg got ready
In vain, magnesium stearate is uniformly mixed, and particle to be filled is made；
(D) it fills：Capsule is filled, finished product is made.
In " A. stocks " step, 30 parts of big discrimination tongue fur is weighed by weight, and taken in " B. dry granulations " step
Dry powder particle is made in big discrimination tongue fur by dry granulation method, then carries out subsequent mixing, filling step.The capsule material is hydroxypropyl
Methylcellulose.
Embodiment 3
The present embodiment provides a kind of increase bone density medicines, include the raw material of following parts by weight：240 parts of calcium carbonate, D- ammonia
100 parts of base glucosamine salt hydrochlorate, 95 parts of collagen, 70 parts of the rhizome of davallia, 70 parts of the root of bidentate achyranthes, 75 parts of Ramulus Taxilli, 55 parts of cortex acanthopanacis, dog
55 parts of ridge, 45 parts of rhizoma homalonemae, 45 parts of Caulis Spatholobi.It further include 38 parts of big discrimination tongue fur.It can glue capsule, tablet, electuary.
The present embodiment provides a kind of capsule preparation method thereofs increasing bone density medicine, include the following steps：
(A) it stocks up：According to parts by weight, 200 parts of calcium carbonate, 90 parts of D-Glucosamine Hydrochloride, collagen are weighed
85 parts, 60 parts of the rhizome of davallia, 60 parts of the root of bidentate achyranthes, 60 parts of Ramulus Taxilli, 45 parts of cortex acanthopanacis, 45 parts of rhizoma cibotii, 35 parts of rhizoma homalonemae, Caulis Spatholobi 35
Part, 3 parts of magnesium stearate；
(B) dry granulation：The rhizome of davallia, the root of bidentate achyranthes, Ramulus Taxilli, cortex acanthopanacis, rhizoma cibotii, rhizoma homalonemae, Caulis Spatholobi are distinguished into dry method system
The particle that moisture content is no more than 5% is made in grain；The operation of dry granulation is：Each bulk pharmaceutical chemicals got ready are added into 3-5 times of weight respectively
70% ethanol water refluxing extraction 1-3 times, filtering, merging filtrate is evaporated, and solid content crushes, by rolling or open
Refining glue machines l-3 times, is pressed into the thin slice of required hardness, then be ground into particle with oscillating granulator.
(C) it mixes：By above-mentioned 7 made kind particle and calcium carbonate, D-Glucosamine Hydrochloride, the collagen egg got ready
In vain, magnesium stearate is uniformly mixed, and particle to be filled is made；
(D) it fills：Capsule is filled, finished product is made.
In " A. stocks " step, 38 parts of big discrimination tongue fur is weighed by weight, and taken in " B. dry granulations " step
Dry powder particle is made in big discrimination tongue fur by dry granulation method, then carries out subsequent mixing, filling step.The capsule material is hydroxypropyl
Methylcellulose.
Three above embodiment clinical cure Contrast on effect：
Every group of selection sufferers of osteoporosis face 100, symptom are：Vertebral compression fracture, can be because of cough, sneezing, slight outer
Wound etc. induces vertebral fracture, in several weeks of fresh vertebral fracture, local pain occurs, percussion pain, multiple centrum pressures occurs in sign
Contracting person, occurs bow-backed, and height becomes short, and when non-vertebral fracture, pain and deformity performance are more serious.0.5g/, 2 times a day, often
It day 3, continuously takes 120 days, counts cure rate, cure later six months statistics recurrence rate, the results are shown in Table 1：
Table 1
| Group | Embodiment 1 | Embodiment 2 | Embodiment 3 |
| Cure rate | 91% | 93% | 92% |
| Recurrence rate | 3% | 2% | 2% |
As can be seen from Table 1, it is notable to treat disease patient effect to osteoporosis for three embodiments of the invention, embodiment 2,3 with
Embodiment 1 is compared, and big discrimination tongue fur is added, and cure rate rises, and recurrence rate declines, it was demonstrated that big discrimination tongue fur controlling for osteoporosis
Treatment plays an important roll.
Claims (6)
1. a kind of increase bone density medicine, which is characterized in that include the raw material of following parts by weight：150-250 parts of calcium carbonate, D- ammonia
70-110 parts of base glucosamine salt hydrochlorate, 70-100 parts of collagen, 40-80 parts of the rhizome of davallia, 40-80 parts of the root of bidentate achyranthes, Ramulus Taxilli 40-80
Part, 30-60 parts of cortex acanthopanacis, 30-60 parts of rhizoma cibotii, 20-50 parts of rhizoma homalonemae, 20-50 parts of Caulis Spatholobi.
2. increase bone density medicine according to claim 1, which is characterized in that further include 20-40 parts of big discrimination tongue fur.
3. increase bone density medicine according to claim 1 or 2, which is characterized in that it can glue capsule, tablet, electuary.
4. the capsule preparation method thereof according to claim 1 for increasing bone density medicine, which is characterized in that including following step
Suddenly：
(A) it stocks up：According to parts by weight, 150-250 parts of calcium carbonate, 70-110 parts of D-Glucosamine Hydrochloride, collagen are weighed
- 100 parts of protein 70,40-80 parts of the rhizome of davallia, 40-80 parts of the root of bidentate achyranthes, 40-80 parts of Ramulus Taxilli, 30-60 parts of cortex acanthopanacis, rhizoma cibotii 30-60
Part, 20-50 parts of rhizoma homalonemae, 20-50 parts of Caulis Spatholobi, 1-4 parts of magnesium stearate；
(B) dry granulation：The rhizome of davallia, the root of bidentate achyranthes, Ramulus Taxilli, cortex acanthopanacis, rhizoma cibotii, rhizoma homalonemae, Caulis Spatholobi are distinguished into dry granulation, system
It is no more than 5% particle at moisture content；The operation of dry granulation is：Each bulk pharmaceutical chemicals got ready are added into 3-5 times of weight respectively
70% ethanol water refluxing extraction 1-3 times, filtering, merging filtrate are evaporated, and solid content crushes, and pass through rolling or open refining
Glue machines l-3 times, is pressed into the thin slice of required hardness, then be ground into particle with oscillating granulator；
(C) it mixes：By above-mentioned 7 made kind particle, 150-250 parts of calcium carbonate, 70-110 parts of D-Glucosamine Hydrochloride, glue
- 100 parts of former protein 70,1-4 parts of magnesium stearate is uniformly mixed, and particle to be filled is made；
(D) it fills：Capsule is filled, finished product is made.
5. the capsule preparation method thereof according to claim 4 for increasing bone density medicine, which is characterized in that " the A. stocks "
In step, 20-40 parts of big discrimination tongue fur is weighed by weight, and take dry granulation method by big discrimination tongue in " B. dry granulations " step
Particle is made in tongue, then carries out subsequent mixing, filling step.
6. the capsule preparation method thereof according to claim 4 for increasing bone density medicine, which is characterized in that the capsule material
For hypromellose.
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