CN102441146B - Use of white vein ointment in preparation of medicines for treating bone fractures - Google Patents
Use of white vein ointment in preparation of medicines for treating bone fractures Download PDFInfo
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Abstract
The invention discloses a new purpose of a white vein ointment in the preparation of medicines for treating bone fractures. The white vein ointment has obvious promotion effects on the bone fracture healing process of fracture model animals, and the effect of the white vein ointment is similar to the effect of traditional medicines traumatological bone-setting tablets.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of new purposes of Chinese medicine.
Background technology
Mainly being divided into of Tibetan medicine the lung-pulse ointment is Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Moschus, Rhizoma Kaempferiae, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, Tronae.Its character is the ointment of yellow-gray, fragrant odour.But relaxing muscles and tendons and activating QI and blood in the collateral is mainly used in aortic arch syndrome, paralysis, and hemiplegia, the muscle tendon is tetanic, the meridians that wound causes and muscle tendon break wound, brothers' contraction urgency, limping etc.
Theoretical according to the Tibetan medicine, the lung-pulse is the venation that human body at first bears at embryo stage, it also is the venation that fetal development obtains nutrition, these venations play again the elite that absorbs diet after the birth, carry waste matter, to guarantee the normal circulation effect of three factors, seven materials, if the function generation of these venations is disorderly, will cause the generation of various diseases.The main pathogenic factor that causes aortic arch syndrome is aggravating activities, damage body venation; Pestilent toxicity pathogenic heat etc. is fallen in the arteries and veins; The mechanical damages such as weapons club cause the disorder of wind and enter sering etc. and form aortic arch syndrome, are the vital energy regualting and blood circulation-promoting collateral dredging to controlling principle.
The doctor among the people of Tibetan is carried according to the Four-Volume Medical Code, " Jingzhubencao " two secretaries, forms proved recipe in conjunction with practical experience, and the epoch pass on from one to another, and use till today.Each constituent of the lung-pulse ointment is theoretical according to Tibetan medicine and pharmacology, analyzes in conjunction with the Chinese medical theory method simultaneously: the circulation of qi promoting of Rhizoma Curcumae Longae removing blood stasis, inducing menstruation to relieve menalgia; The Semen Myristicae warming middle-JIAO to promote flow of QI, relieving diarrhea with astringents; The Radix Et Rhizoma Nardostachyos regulating QI to relieve pain, relieving stagnation and activating the spleen; The Actinolitum strenthening the bones and muscles; The Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription; The Moschus refreshment of having one's ideas straightened out, promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain.The Rhizoma Zingiberis warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, the dampness expectorant; Fructus cari carvi is regulated the flow of vital energy, pain relieving, detoxifcation; The Rhizoma Acori Calami stomach warming, anti-inflammatory analgetic; The Pericarpium Zanthoxyli warming middle-JIAO to relieve pain, killing parasites for relieving itching; The Tronae removing toxic substances and promoting pus discharge eliminates indigestion and phlegm, the anthelmintic relieving constipation.
Summary of the invention
The object of the present invention is to provide the second medical usage of the lung-pulse ointment, i.e. new purposes in preparation set a broken bone medicine.
For real above-mentioned purpose, the present invention has adopted the rabbit radial animal fracture model that the lung-pulse ointment is studied as the bone healing medicine, and with traditional bone healing medicine---bone setting tablet compares, the result shows: low (0.33g/kg), in (0.67g/kg), the lung-pulse ointment of high (1.34g/kg) dosage has obvious facilitation to fracture model animal bone injury healing process, it promotes that the bone injury healing effect is close with the conventional medicament bone setting tablet, it has the characteristics of dual modulation to muscular tension, and the bone metabolism correlative protein expression level in the callus formation process is had obvious regulating action.
Particularly, the present invention shows that the oral bone setting tablet of the lung-pulse ointment machin of above-mentioned three dosage groups is on the not obviously impact of Ipsilateral limb joint girth, but all can obviously increase fracture model animal Ipsilateral foot soil fertility and range of motion, the lung-pulse ointment can obviously shorten suffers from afterburning touchdown time in the sufficient functional rehabilitation process, and improve fracture model animal serum calcium level, show obvious promotion union of fracture effect.In addition, the oral bone setting tablet of the lung-pulse ointment machin low, middle dosage can increase Ipsilateral limb muscular tension, the lung-pulse ointment of high dose then shows the effect that reduces Ipsilateral limb muscular tension, and prompting the lung-pulse ointment has the characteristics of dual modulation to the regulating action of muscular tension.The present invention finds that also the lung-pulse ointment has obvious facilitation to the expression of the BMP of callus formation place and FGF and accelerates the bone trabecular maturation process of agglutination and callus place of callus, and prompting the lung-pulse ointment may have regulating action to the bone metabolism correlative protein expression of callus formation part.
More specifically, the administering mode of the lung-pulse ointment of the present invention is external application.
The present invention also provides the lung-pulse ointment to use in the medicine of preparation promotion union of fracture,
Description of drawings
Fig. 1 is that external the lung-pulse ointment is slandered the impact that lower limb soil fertility to rabbit fracture of radius agglutination.
Be administered once every day after each treated animal modeling, administration began to detect in the 13rd day Ipsilateral foot soil fertility, administration was put to death animal on the 60th day and is left and taken Pathologic specimen.Con: Normal group; Fracture: fracture model group; SKJGP: bone setting tablet group; BaiMai: the lung-pulse ointment group.Means ± SEM,
*P＜0.05,
*P＜0.01 is compared with Normal group; #P＜0.05, ##P＜0.01 is compared with the fracture model group.
Fig. 2 is external the lung-pulse ointment is slandered the lower limb muscular tension on rabbit fracture of radius agglutination impact.
Be administered once every day after each treated animal modeling, detects Ipsilateral limb fracture muscular tension, sink the degree of depth as the observed and recorded index take 100g pressure lower epidermis, and administration was put to death animal on the 60th day and left and taken Pathologic specimen.Con: Normal group; Fracture: fracture model group; SKJGP: bone setting tablet group; BaiMai: the lung-pulse ointment group.Means ± SEM,
*P＜0.05,
*P＜0.01 is compared with Normal group; #P＜0.05, ##P＜0.01 is compared with the fracture model group.
Fig. 3 is external the lung-pulse ointment is slandered lower limb swelling degree on rabbit fracture of radius agglutination impact.
Be administered once every day after each treated animal modeling, detects Ipsilateral limb fracture girth as the swelling index, and administration was put to death animal on the 60th day and left and taken Pathologic specimen.Con: Normal group; Fracture: fracture model group; SKJGP: bone setting tablet group; BaiMai: the lung-pulse ointment group.Means ± SEM,
*P＜0.01 is compared with Normal group.
Fig. 4 is external the lung-pulse ointment is slandered lower limb exercising elbow joint degree on rabbit fracture of radius agglutination impact.
Be administered once every day after each treated animal modeling, and it is the observed and recorded index that detection Ipsilateral forelimb elbow joint opens maximum angle, and administration was put to death animal on the 60th day and left and taken Pathologic specimen.Con: Normal group; Fracture: fracture model group; SKJGP: bone setting tablet group; BaiMai: the lung-pulse ointment group.Means ± SEM,
*P＜0.01 is compared with Normal group.
Fig. 5 is that external the lung-pulse ointment is slandered the impact that lower limb begins touchdown time to rabbit fracture of radius agglutination.
Be administered once every day after each treated animal modeling, and it is the observed and recorded index that detection Ipsilateral forelimb begins touchdown time, and administration was put to death animal on the 60th day and left and taken Pathologic specimen.Mod: fracture model group; SKJGP: bone setting tablet group; BaiMai: the lung-pulse ointment group.Means±SEM。
Fig. 6 is external the lung-pulse ointment is slandered the afterburning touchdown time of lower limb on rabbit fracture of radius agglutination impact.
Be administered once every day after each treated animal modeling, and detecting the afterburning touchdown time of Ipsilateral forelimb is the observed and recorded index, and administration was put to death animal on the 60th day and left and taken Pathologic specimen.Mod: fracture model group; SKJGP: bone setting tablet group; BaiMai: the lung-pulse ointment group.Means ± SEM,
*P＜0.05,
*P＜0.01 is compared with the fracture model group.
Fig. 7 is that external the lung-pulse ointment is on the impact of serum alkaline phosphatase level in the rabbit fracture of radius agglutination.
Be administered once every day after each treated animal modeling, and animal was put to death in administration on the 60th day, detected serum alkaline phosphatase (ALP) level.Con: Normal group; Mod: fracture model group; SKJGP: bone setting tablet group; BaiMai: the lung-pulse ointment group.Means ± SEM,
*P＜0.05,
*P＜0.01 is compared with the fracture model group.
Fig. 8 is that external the lung-pulse ointment is on the impact of serum calcium levels in the rabbit fracture of radius agglutination.
Be administered once every day after each treated animal modeling, and animal was put to death in administration on the 60th day, detected serum calcium levels.Con: Normal group; Mod: fracture model group; SKJGP: bone setting tablet group; BaiMai: the lung-pulse ointment group.Means ± SEM, #P＜0.05, ##P＜0.01 is compared with the fracture model group.
Fig. 9 is that external the lung-pulse ointment is on the impact of serum paraoxonase content in the rabbit fracture of radius agglutination.
Be administered once every day after each treated animal modeling, and animal was put to death in administration on the 60th day, detected serum paraoxonase content.Con: Normal group; Mod: fracture model group; SKJGP: bone setting tablet group; BaiMai: the lung-pulse ointment group.Means±SEM。
Figure 10 is that external the lung-pulse ointment is on the impact of rabbit fracture of radius agglutination callus formation place bone morphogenetic protein level.
Be administered once every day after each treated animal modeling, and animal was put to death in administration on the 60th day, and pathology detect callus formation place's bone morphogenetic protein (BMP) expression.Con: Normal group; Mod: fracture model group; SKJGP: bone setting tablet group; BaiMai: the lung-pulse ointment group.Means ± SEM, #P＜0.05 is compared with the fracture model group.
Figure 11 is that external the lung-pulse ointment is on the impact of rabbit fracture of radius agglutination callus formation place basic fibroblast growth factor level.
Be administered once every day after each treated animal modeling, and animal was put to death in administration on the 60th day, and pathology detect callus formation place's basic fibroblast growth factor (FGF) expression.Con: Normal group; Mod: fracture model group; SKJGP: bone setting tablet group; BaiMai: the lung-pulse ointment group.Means ± SEM,
*P＜0.05 is compared with Normal group; #P＜0.05, ##P＜0.01 is compared with the fracture model group.
Figure 12 is that external the lung-pulse ointment is on the impact of rabbit fracture of radius agglutination callus formation place area of new bone girder area.
Be administered once every day after each treated animal modeling, and animal was put to death in administration on the 60th day, and pathology detect callus formation place area of new bone girder area.Con: Normal group; Mod: fracture model group; SKJGP: bone setting tablet group; BaiMai: the lung-pulse ointment group.Means ± SEM,
*P＜0.05 is compared with Normal group; #P＜0.05 is compared with the fracture model group.
Figure 13 is that external the lung-pulse ointment is on the impact of rabbit fracture of radius X-ray scanning scoring in callus formation place after 7 days.
Be administered once every day after each treated animal modeling, and administration was carried out the X-ray scanning fracture on the 7th day, carries out relatively callus healing state of histological scores.Con: Normal group; Mod: fracture model group; SKJGP: bone setting tablet group; BaiMai: the lung-pulse ointment group.Means ± SEM,
*P＜0.01 is compared with Normal group.
Figure 14 is that external the lung-pulse ointment is on the impact of rabbit fracture of radius X-ray scanning scoring in callus formation place after 14 days.
Be administered once every day after each treated animal modeling, and administration was carried out the X-ray scanning fracture on the 14th day, carries out relatively callus healing state of histological scores.Con: Normal group; Mod: fracture model group; SKJGP: bone setting tablet group; BaiMai: the lung-pulse ointment group.Means ± SEM,
*P＜0.01 is compared with Normal group; #P＜0.05 is compared with the fracture model group.
Figure 15 is that external the lung-pulse ointment is on the impact of rabbit fracture of radius X-ray scanning scoring in callus formation place after 60 days.
Be administered once every day after each treated animal modeling, and administration was carried out the X-ray scanning fracture on the 60th day, carries out relatively callus healing state of histological scores.Con: Normal group; Mod: fracture model group; SKJGP: bone setting tablet group; BaiMai: the lung-pulse ointment group.Means ± SEM,
*P＜0.01 is compared with Normal group; #P＜0.05 is compared with the fracture model group.
Figure 16 is the liver histopathological analysis figure (Normal group) of the rabbit radial in the 8th week of fracture.
Figure 17 is the liver histopathological analysis figure (fracture model group) of the rabbit radial in the 8th week of fracture.
Figure 18 is the liver histopathological analysis figure (bone setting tablet group) of the rabbit radial in the 8th week of fracture.
Figure 19 is the liver histopathological analysis figure (the lung-pulse ointment low dose group) of the rabbit radial in the 8th week of fracture.
Figure 20 is the liver histopathological analysis figure (dosage group in the lung-pulse ointment) of the rabbit radial in the 8th week of fracture.
Figure 21 is the liver histopathological analysis figure (the lung-pulse ointment high dose group) of the rabbit radial in the 8th week of fracture.
The specific embodiment
Material:
The lung-pulse ointment: lot number is provided by XiZang QiZheng Tibetan pharmaceuticals Co., Ltd: 090910, specification: 20g/ props up * 1/box;
Laboratory animal: provided by Chinese department of Chinese medicine institute Experimental Animal Center, raise in laboratory animal room of fundamental research institute of Chinese department of Chinese medicine institute.
Laboratory animal is 4 monthly age white big ear rabbits, and body weight 3.0 ± 0.5kg grouping: laboratory animal is divided into 6 groups at random, and every group of 10-11 only.Normal group, model group, positive controls (bone setting tablet 0.35g/kg), the basic, normal, high dosage group of the lung-pulse ointment (0.33,0.67,1.34g/kg), amount to 60, wherein, dosage unit g/kg refers to the animals administer 1g (annotate: the lung-pulse dosage is in 5cm=1g) of every 1kg body weight.
Modeling method: after the anesthesia of 3% pentobarbital sodium, adopt the electronic universal material experiment-machine to cause fracture model, form rabbit radial fracture model (taking X-ray after the modeling, whether successful to confirm fracture model).This animal fracture model shows many-sided function assessment similar to clinical fracture, blood biochemistry, pathologic structure equivalent damage and sexually revises.Tradition bone healing medicine---bone setting tablet can promote the improvement of its Ipsilateral limb function, improve its serum calcium level, promote its bone injury healing process, can reflect more objectively function, physiology and pathological change in fracture and the agglutination, and can be used for the relevant research of intervening medicine, this animal model and related drugs data are reliable.
The route of administration of experimental drug and time: external application.2 months time, 1 times/day.
Positive control drug: bone setting tablet, (commercially available, production firm: Pan Shoude, the accurate word 221021461 of lot number traditional Chinese medicines, trade name: bone setting tablet), route of administration: gavage 0.35g/kg d.
Draw materials: got in 2 months after administration and respectively organize rabbit, serum alkaline phosphatase (ALP), blood Ca2+, blood P are measured in the heart blood sampling; Get radius, fixing, dehydration, decalcification, HE stained and bone morphogenetic protein (BMP), basic fibroblast growth factor (FGF).
[embodiment 1] external the lung-pulse ointment is slandered the impact that lower limb soil fertility to rabbit fracture of radius agglutination
13 days future trouble parapodums of external the lung-pulse ointment high dose group animal bone fracture soil fertility apparently higher than the fracture model group, in the external the lung-pulse ointment low dosage and oral bone setting tablet can obviously raise fracture animal after 16 days Ipsilateral foot soil fertility, fracture after 47 days each treated animal Ipsilateral foot soil fertility all return to physiological level, there was no significant difference between each group, data are seen Fig. 1.
[embodiment 2] external the lung-pulse ointment is slandered the impact of lower limb muscular tension on rabbit fracture of radius agglutination
The fracture model animal hinders the lower limb muscular tension and obviously raises, oral bone setting tablet is 1 to 9 day Ipsilateral limb muscular tension behind the elevation model animal bone fracture further, showing as the degree of depth of sinking reduces, low, the middle dosage external of the lung-pulse ointment Ipsilateral limb muscular tension that can raise, high dose then shows the effect that reduces muscular tension, and data are seen Fig. 2.
[embodiment 3] external the lung-pulse ointment is slandered the impact of lower limb swelling on rabbit fracture of radius agglutination
The fracture model animal hinders lower limb and obvious swelling occurs, and showing as Ipsilateral limb fracture girth obviously increases, and oral bone setting tablet and each dosage of external the lung-pulse ointment all do not show the impact on fracture model animal Ipsilateral limb fracture girth, and data are seen Fig. 3.
[embodiment 4] external the lung-pulse ointment is slandered the impact of lower limb exercising elbow joint degree on rabbit fracture of radius agglutination
Animal exercising elbow joint degree obviously descends after the fracture, rear the 13rd day animal pattern exercising elbow joint degree returns to the normal group level substantially to fracturing, 1 to 4 day Ipsilateral forelimb elbow joint opened maximum angle after oral bone setting tablet can obviously increase the fracture model animal bone fracture, 1 to 8 day Ipsilateral forelimb elbow joint opened maximum angle after each dosage of external the lung-pulse ointment can obviously increase the fracture model animal bone fracture, its effect and bone setting tablet are suitable, and duration of efficacy is longer than bone setting tablet.Fracturing, model and each administration treated animal exercising elbow joint degree return to physiological level after 9 days, and data are seen Fig. 4.
[embodiment 5] external the lung-pulse ointment is on suffering from the impact of sufficient touchdown time in the rabbit fracture of radius agglutination
Oral bone setting tablet is suffered from the fracture model animal and is begun to land in the sufficient restore funcitons process and the not impact of afterburning touchdown time, and external the lung-pulse ointment is low, high dose can obviously shorten the fracture model animal and suffer from the afterburning touchdown time of foot, and data are seen Fig. 5,6.
[embodiment 6] external the lung-pulse ointment is on the impact of serum bone metabolism related biochemical indicator in the rabbit fracture of radius agglutination
Fracture model animal serum alkaline phosphatase enzyme level has downward trend, but does not have statistical significance, and blood calcium and serium inorganic phosphorus level and normal group are relatively without significant change.Oral bone setting tablet is on the not impact of fracture model animal serum alkali phosphatase and serium inorganic phosphorus level, but obvious elevation model animal serum calcium level.External the lung-pulse ointment low dosage is elevation model animal serum calcium level obviously, and its effect is similar to bone setting tablet, and data are seen Fig. 7,8,9.
[embodiment 7] external the lung-pulse ointment is on the impact of callus pathologic structure in the rabbit fracture of radius agglutination and bone metabolism associated protein level
Fracture model animal callus formation place's bone morphogenetic protein (BMP) level is lower than Normal group, but there is not statistical significance, its basic fibroblast growth factor (FGF) level is starkly lower than Normal group, and the model animal bone crust formation place bone trabecula area of fracturing after 60 days is apparently higher than Normal group.Oral bone setting tablet is on the fracture model animal callus BMP of place and FGF level and the not impact of bone trabecula area.In the external the lung-pulse ointment and high dose all obviously the elevation model animal callus BMP of place and FGF level, the lung-pulse ointment high dose group 60 days callus place bone trabecula areas of fracturing are lower than the fracture model animal, and data are seen Figure 10,11,12.
[embodiment 8] external the lung-pulse ointment is on the impact of callus X-ray scanning scoring in the rabbit fracture of radius agglutination
Callus X-ray scanning scoring in the 1st, 7,14 and 60 day is starkly lower than Normal group behind the fracture model animal bone fracture.Oral bone setting tablet is on not impact of fracture model animal callus place X ray scoring.External the lung-pulse ointment is low and high dose can be distinguished elevation model animal the 14th and 60 days callus place X-ray scannings are marked, and data are seen Figure 13,14,15.
[embodiment 9] external the lung-pulse ointment is to the liver histopathological analysis of rabbit fracture of radius healing
Send Wangjing Hospital, China Academy Of Traditional Chinese Medicine pharmacological room to carry out liver histopathological analysis the rabbit radial in the 8th week of fracture of six experimental grouies, the organized processing mode is HE dyeing.Analysis result is as follows:
Normal group: visible Compact bone is the flaggy shape under the mirror, and bone lacuna is neat and orderly, structural integrity, and it is damaged to have no osseous tissue, as shown in figure 16.Conclusion is that osseous tissue form, structure are normal, has no pathological change.
The fracture model group: visible new bone growth under the mirror, freshman bone tissue is bone trabecula.The new bone growth place has hone lamella to form, as shown in figure 17.Conclusion is the hone lamella of area of new bone girder and interruption.
The bone setting tablet group: visible new bone growth under the mirror, freshman bone tissue is bone trabecula.The new bone growth place has hone lamella to form, as shown in figure 18.Conclusion is the hone lamella of area of new bone girder and interruption.
The lung-pulse ointment low dose group: visible new bone growth under the mirror, freshman bone tissue is bone trabecula.The new bone growth place has hone lamella to form, as shown in figure 19.Conclusion is the hone lamella of area of new bone girder and interruption.
Dosage group in the lung-pulse ointment: visible new bone growth under the mirror, freshman bone tissue is bone trabecula.The new bone growth place has hone lamella to form, as shown in figure 20.Conclusion is the hone lamella of area of new bone girder and interruption.
The lung-pulse ointment high dose group: visible new bone growth under the mirror, freshman bone tissue is bone trabecula, visible more bone trabecula gap.The new bone growth place has hone lamella to form, as shown in figure 21.Conclusion is the hone lamella of area of new bone girder and interruption.
Claims (3)
1. the application of the lung-pulse ointment in preparation treatment fracture medicine.
2. application claimed in claim 1, the route of administration of wherein said the lung-pulse ointment are external application.
3. the application of the lung-pulse ointment in preparation promotion union of fracture medicine.
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| CN1840154A (en) * | 2006-01-25 | 2006-10-04 | 甘肃奇正藏药有限公司 | Ointment for treating nervous damage and preparation method thereof |
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| CN1840154A (en) * | 2006-01-25 | 2006-10-04 | 甘肃奇正藏药有限公司 | Ointment for treating nervous damage and preparation method thereof |
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| Title |
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| 王和鸣主编.骨折概论.《中医骨伤科学第二版》.中国中医药出版社,2007,第136页. * |
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