CN108289969A - 整合了阳离子甾族抗微生物化合物的医疗装置 - Google Patents

整合了阳离子甾族抗微生物化合物的医疗装置 Download PDF

Info

Publication number
CN108289969A
CN108289969A CN201680068028.6A CN201680068028A CN108289969A CN 108289969 A CN108289969 A CN 108289969A CN 201680068028 A CN201680068028 A CN 201680068028A CN 108289969 A CN108289969 A CN 108289969A
Authority
CN
China
Prior art keywords
csa
medical device
alkyl
compounds
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680068028.6A
Other languages
English (en)
Chinese (zh)
Inventor
卡尔·吉尼伯格
保罗·B·萨维奇
罗纳德·L·布拉肯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Brigham Young University
Original Assignee
Brigham Young University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham Young University filed Critical Brigham Young University
Publication of CN108289969A publication Critical patent/CN108289969A/zh
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/04Macromolecular materials
    • A61L29/06Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08Materials for coatings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08Materials for coatings
    • A61L29/085Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/145Hydrogels or hydrocolloids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0017Catheters; Hollow probes specially adapted for long-term hygiene care, e.g. urethral or indwelling catheters to prevent infections
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/08Tubes; Storage means specially adapted therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/22Lipids, fatty acids, e.g. prostaglandins, oils, fats, waxes
    • A61L2300/222Steroids, e.g. corticosteroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404Biocides, antimicrobial agents, antiseptic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/41Anti-inflammatory agents, e.g. NSAIDs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606Coatings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00Materials characterised by their function or physical properties
    • A61L2400/10Materials for lubricating medical devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/04Tracheal tubes
    • A61M16/0465Tracheostomy tubes; Devices for performing a tracheostomy; Accessories therefor, e.g. masks, filters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0043Catheters; Hollow probes characterised by structural features
    • A61M2025/0056Catheters; Hollow probes characterised by structural features provided with an antibacterial agent, e.g. by coating, residing in the polymer matrix or releasing an agent out of a reservoir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/02General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0205Materials having antiseptic or antimicrobial properties, e.g. silver compounds, rubber with sterilising agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/02General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0238General characteristics of the apparatus characterised by a particular materials the material being a coating or protective layer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2207/00Methods of manufacture, assembly or production

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201680068028.6A 2015-09-21 2016-09-21 整合了阳离子甾族抗微生物化合物的医疗装置 Pending CN108289969A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562221613P 2015-09-21 2015-09-21
US62/221,613 2015-09-21
US15/270,876 2016-09-20
US15/270,876 US20170080128A1 (en) 2015-09-21 2016-09-20 Novel endotracheal tube for the reduction of intubation-related complication in neonates and babies
PCT/US2016/052771 WO2017053355A1 (en) 2015-09-21 2016-09-21 Medical devices integrating cationic steroidal antimicrobial compounds

Publications (1)

Publication Number Publication Date
CN108289969A true CN108289969A (zh) 2018-07-17

Family

ID=58276179

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680068028.6A Pending CN108289969A (zh) 2015-09-21 2016-09-21 整合了阳离子甾族抗微生物化合物的医疗装置

Country Status (8)

Country Link
US (1) US20170080128A1 (enExample)
EP (1) EP3352801A4 (enExample)
JP (1) JP2018528056A (enExample)
KR (1) KR20180098219A (enExample)
CN (1) CN108289969A (enExample)
AU (1) AU2016328964A1 (enExample)
CA (1) CA2999483A1 (enExample)
WO (1) WO2017053355A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2303026B1 (en) 2008-06-17 2020-09-09 Brigham Young University Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods
ES2728135T3 (es) 2011-07-20 2019-10-22 Univ Brigham Young Materiales de hidrogel que incorporan un compuesto de elución de ceragenina
EP2941253B1 (en) 2013-01-07 2021-08-11 Brigham Young University Cationic steroid antimicrobial agents for use in treating cancer
KR102282183B1 (ko) 2013-03-15 2021-07-26 브라이엄 영 유니버시티 염증, 자가면역 장애 및 통증의 치료 방법
US10568893B2 (en) 2013-03-15 2020-02-25 Brigham Young University Methods for treating inflammation, autoimmune disorders and pain
US11524015B2 (en) 2013-03-15 2022-12-13 Brigham Young University Methods for treating inflammation, autoimmune disorders and pain
US11690855B2 (en) 2013-10-17 2023-07-04 Brigham Young University Methods for treating lung infections and inflammation
US20150203527A1 (en) 2014-01-23 2015-07-23 Brigham Young University Cationic steroidal antimicrobials
CA2844321C (en) 2014-02-27 2021-03-16 Brigham Young University Cationic steroidal antimicrobial compounds
US10220045B2 (en) 2014-03-13 2019-03-05 Brigham Young University Compositions and methods for forming stabilized compositions with reduced CSA agglomeration
US9931350B2 (en) 2014-03-14 2018-04-03 Brigham Young University Anti-infective and osteogenic compositions and methods of use
US10238665B2 (en) 2014-06-26 2019-03-26 Brigham Young University Methods for treating fungal infections
US10441595B2 (en) 2014-06-26 2019-10-15 Brigham Young University Methods for treating fungal infections
US10155788B2 (en) 2014-10-07 2018-12-18 Brigham Young University Cationic steroidal antimicrobial prodrug compositions and uses thereof
WO2016172543A1 (en) 2015-04-22 2016-10-27 Savage Paul B Methods for the synthesis of ceragenins
US10226550B2 (en) 2016-03-11 2019-03-12 Brigham Young University Cationic steroidal antimicrobial compositions for the treatment of dermal tissue
US10959433B2 (en) 2017-03-21 2021-03-30 Brigham Young University Use of cationic steroidal antimicrobials for sporicidal activity
US20180272034A1 (en) * 2017-03-21 2018-09-27 Brigham Young University Use of csa compounds to prevent microbial build-up or fouling of medical implants
US12186328B2 (en) * 2019-05-23 2025-01-07 Brigham Young University Use of CSA compounds to stimulate stem cells and hair growth

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5687714A (en) * 1995-10-10 1997-11-18 The United States Of America As Represented By The Department Of Health And Human Services Self-cleaning endotracheal tube apparatus
CN1236322A (zh) * 1996-11-06 1999-11-24 斯蒂斯生物聚合物公司 用于超声成象的含有气体空间的回声涂层
CN101247838A (zh) * 2005-08-26 2008-08-20 贝克顿迪肯森公司 对弹性密封制品进行消毒的方法
CN104039369A (zh) * 2011-07-20 2014-09-10 布莱阿姆青年大学 疏水性塞拉集宁化合物和包含该化合物的装置
US20140271761A1 (en) * 2011-08-25 2014-09-18 Brigham Young University Incorporation of particulate ceragenins in polymers
US20150203527A1 (en) * 2014-01-23 2015-07-23 Brigham Young University Cationic steroidal antimicrobials

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4248236A (en) * 1978-12-26 1981-02-03 Linder Gerald S Packaged medical appliance
JPS6080457A (ja) * 1983-10-07 1985-05-08 ユニチカ株式会社 抗菌剤徐放性導尿カテ−テル
US4723950A (en) * 1984-12-12 1988-02-09 C. R. Bard, Inc. Urine drainage bag outlet with barrier against microbial infection
US5624704A (en) * 1995-04-24 1997-04-29 Baylor College Of Medicine Antimicrobial impregnated catheters and other medical implants and method for impregnating catheters and other medical implants with an antimicrobial agent
US7820734B2 (en) * 1998-10-07 2010-10-26 Tyco Healthcare Group Lp Antimicrobial lubricious coating
US6329488B1 (en) * 1998-11-10 2001-12-11 C. R. Bard, Inc. Silane copolymer coatings
US6921390B2 (en) * 2001-07-23 2005-07-26 Boston Scientific Scimed, Inc. Long-term indwelling medical devices containing slow-releasing antimicrobial agents and having a surfactant surface
WO2005007209A1 (en) * 2003-07-17 2005-01-27 Bioretec Oy Synthetic, bioabsorbable polymer materials and implants
US9186511B2 (en) * 2006-10-13 2015-11-17 Cyberonics, Inc. Obstructive sleep apnea treatment devices, systems and methods
US20090099531A1 (en) * 2007-10-15 2009-04-16 Griesbach Iii Henry Louis Packaging for selectivity lubricating part of a medical device
RU2652308C2 (ru) * 2011-09-13 2018-04-25 Брайем Янг Юниверсити Способы и продукты для заживления ран тканей
JP6038154B2 (ja) * 2011-09-13 2016-12-07 ブリガム・ヤング・ユニバーシティBrigham Young University 骨疾患および破断骨治療のための組成物
US20130280391A1 (en) * 2012-04-24 2013-10-24 Brigham Young University Anti-microbial wash compositions including ceragenin compounds and methods of use for treating non-meat food products

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5687714A (en) * 1995-10-10 1997-11-18 The United States Of America As Represented By The Department Of Health And Human Services Self-cleaning endotracheal tube apparatus
CN1236322A (zh) * 1996-11-06 1999-11-24 斯蒂斯生物聚合物公司 用于超声成象的含有气体空间的回声涂层
CN101247838A (zh) * 2005-08-26 2008-08-20 贝克顿迪肯森公司 对弹性密封制品进行消毒的方法
CN104039369A (zh) * 2011-07-20 2014-09-10 布莱阿姆青年大学 疏水性塞拉集宁化合物和包含该化合物的装置
US20140271761A1 (en) * 2011-08-25 2014-09-18 Brigham Young University Incorporation of particulate ceragenins in polymers
US20150203527A1 (en) * 2014-01-23 2015-07-23 Brigham Young University Cationic steroidal antimicrobials

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DAVID P. ELDER ET AL: "The Utility of Sulfonate Salts in Drug Development", 《JOURNAL OF PHARMACEUTICAL SCIENCES》 *
DAVID S. JONES ET AL: "Physicochemical Characterization of Hexetidine-Impregnated Endotracheal Tube Poly(Vinyl Chloride) and Resistance to Adherence of Respiratory Bacterial Pathogens", 《PHARMACEUTICAL RESEARCH》 *

Also Published As

Publication number Publication date
US20170080128A1 (en) 2017-03-23
EP3352801A4 (en) 2019-05-15
WO2017053355A1 (en) 2017-03-30
CA2999483A1 (en) 2017-03-30
AU2016328964A1 (en) 2018-04-12
KR20180098219A (ko) 2018-09-03
JP2018528056A (ja) 2018-09-27
EP3352801A1 (en) 2018-08-01

Similar Documents

Publication Publication Date Title
CN108289969A (zh) 整合了阳离子甾族抗微生物化合物的医疗装置
US11253634B2 (en) Cationic steroidal antibiotic compositions for the treatment of dermal tissue
ES2725784T3 (es) Compuestos de ceragenina hidrófobos y dispositivos que incorporan al mismo
AU2004206755B2 (en) An otorhinological delivery device
EP2075014B9 (en) Compositions and methods for coating medical implants
ES2750034T3 (es) Composiciones antimicrobianas de amplio espectro basadas en combinaciones de taurolidina y protamina y dispositivos médicos que contienen tales composiciones
CA2535926A1 (en) N,n-dihalogenated amino acids and derivatives
CN101641104A (zh) 感染性皮肤和粘膜疾病治疗药
ES2755754T3 (es) Métodos para tratar una infección pulmonar bacteriana mediante el uso de fluoroquinolonas
Komeda et al. The influence of interleukin-1 receptor antagonist transgene on spiral ganglion neurons
US20190099523A1 (en) Film-forming composition for a ph-dependant sustained release of the active agent
KR20100017345A (ko) 살생물성 의료장치, 삽입물 및 상처 드레싱
US20180272034A1 (en) Use of csa compounds to prevent microbial build-up or fouling of medical implants
US20240189486A1 (en) Antimicrobial cationic peptoid and n-subtituted peptidic copolymers, preparation and uses thereof
Deshmukh-Reeves et al. Formation and Prevention of Biofilms on Airway Management Devices
US20250171511A1 (en) Antiviral peptides and methods of use thereof
KR101775079B1 (ko) 유기 게르마늄을 함유한 카테터 및 이의 제조방법
WO2017060489A1 (en) Methods for inhibiting or reducing bacterial biofilms
EP4319849A1 (en) Antimicrobial eluting airway devices
ten Hallers et al. The Saanen goat as an animal model for post-laryngectomy research: practical implications
US20220288013A1 (en) 1,8-cineol coated implants
CN118791572A (zh) 一种免疫调节正电抗炎肽及其应用
Hendrickson SURGERY OF THE EQUINE UPPER RESPIRATORY TRACT
WO2002090436A2 (en) Bioactive biomimetic elastomers
Kwon et al. The poppy seed test for colovesical fistulas

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20180717

WD01 Invention patent application deemed withdrawn after publication