CN108272971A - 一种治疗脓毒症的药物及其制备方法 - Google Patents
一种治疗脓毒症的药物及其制备方法 Download PDFInfo
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Abstract
本发明提供一种治疗脓毒症的药物及其制备方法,由以下重量份数的原料制成:菊花15‑20份、当归15‑20份、夏枯草15‑20份、公英20‑25份、黄芪20‑25份、黄精15‑20份、肉桂20‑25份、黄芩3‑10份、丹参4‑10份、赤芍3‑9份、玄参10‑15份、大黄2‑8份、三七7‑15份、枳实4‑15份、白头翁3‑10份、败酱草5‑15份以及竹叶15‑20份,发明制备的脓毒症的药物,能够有效提高治疗效果,无毒副作用和不良反应,其制备采用分步制备提取粉末并混合的方法,制备方法新颖,简单,适合大规模工业化生产的需要。
Description
技术领域
本发明是一种治疗脓毒症的药物及其制备方法,属于医药领域。
背景技术
现有技术中,脓毒症(sepsis)是指由感染引起的全身炎症反应综合征(systemicinflammatoryresponsesyndrome,SIRS),临床上证实有细菌存在或有高度可疑感染灶。虽然脓毒症是由感染引起,但是一旦发生后,其发生发展遵循其自身的病理过程和规律,故从本质上讲脓毒症是机体对感染性因素的反应。脓毒症发生率高,全球每年有超过1800万严重脓毒症病例,美国每年有75万例脓毒症患者,并且这一数字还以每年1.5%~8.0%的速度上升。脓毒症的病情凶险,病死率高,全球每天约14,000人死于其并发症,美国每年约21.5万人死亡。据国外流行病学调查显示,脓毒症的病死率已经超过心肌梗死,成为重症监护病房内非心脏病人死亡的主要原因。近年来,尽管抗感染治疗和器官功能支持技术取得了长足的进步,脓毒症的病死率仍高达30%~70%。脓毒症治疗花费高,医疗资源消耗大,严重影响人类的生活质量,已经对人类健康造成巨大威胁。因此,2001年欧洲重症学会、美国重症学会和国际脓毒症论坛发起“拯救脓毒症战役”(survivingsepsiscampain,SSC),2002年欧美国家多个组织共同发起并签署“巴塞罗那宣言”,并且进一步制定基于对脓毒症研究的循证医学证据并不断更新脓毒症治疗指南即SSC指南,以改进脓毒症的治疗措施,降低脓毒症的死亡率。
发明内容
针对现有技术存在的不足,本发明目的是提供一种治疗脓毒症的药物及其制备方法,以解决上述背景技术中提出的问题,本发明使用方便,便于操作,稳定性好,可靠性高。
为了实现上述目的,本发明是通过如下的技术方案来实现:一种治疗脓毒症的药物,由以下重量份数的原料制成:菊花15-20份、当归15-20份、夏枯草15-20份、公英20-25份、黄芪20-25份、黄精15-20份、肉桂20-25份、黄芩3-10份、丹参4-10份、赤芍3-9份、玄参10-15份、大黄2-8份、三七7-15份、枳实4-15份、白头翁3-10份、败酱草5-15份以及竹叶15-20份。
进一步地,所述药物还包括蝶毛菌3-9份。
进一步地,所述药物还包括荷叶20-25份。
药物制备方法,包括如下步骤:
S1:取菊花15-20份、当归15-20份、夏枯草15-20份、公英20-25份、黄芪20-25份、黄精15-20份、肉桂20-25份、黄芩3-10份、丹参4-10份、玄参10-15份、大黄2-8份、白头翁3-10份、败酱草5-15份、蝶毛菌3-9份以及竹叶15-20份置于粉碎机粉碎,置于煎锅中文火煎制得到混合液A;
S2:取赤芍3-9份,三七7-15份,枳实4-15份,放入砂锅中,用水浸没,加热至60-80°C,蒸煮1-3小时,加入2份酒石酸钠,蒸煮6-8小时,降温至室温,静置3-5小时,过滤得混合液B,蒸干制成粉末B;
S3:将粉末B加入到混合液A中文火煎熬,加入荷叶20-25份,煎熬2-4小时后静置冷却得到混合液C,加入0.1-0.4份酵母发酵液,置于25-35°C的条件下发酵3-6天,加入3-5倍重量份数的水回流提取3次,合并得到混合液D,
S4:蒸干混合液D制成粉末D,装入胶囊制成。
进一步地,所述粉末D研磨至粒径0.02-0.05mm。
本发明的有益效果:本发明的一种治疗脓毒症的药物及其制备方法,本发明制备的脓毒症的药物,能够有效提高治疗效果,无毒副作用和不良反应,其制备采用分步制备提取粉末并混合的方法,制备方法新颖,简单,适合大规模工业化生产的需要,对口干、火旺、目涩,或由风、寒、湿引起的肢体疼痛、麻木的疾病均有一定的疗效。主治感冒风热,头痛病等。对眩晕、头痛、耳鸣有防治作用。
具体实施方式
为使本发明实现的技术手段、创作特征、达成目的与功效易于明白了解,下面结合具体实施方式,进一步阐述本发明。
本发明提供一种技术方案:一种治疗脓毒症的药物,由以下重量份数的原料制成:菊花15-20份、当归15-20份、夏枯草15-20份、公英20-25份、黄芪20-25份、黄精15-20份、肉桂20-25份、黄芩3-10份、丹参4-10份、赤芍3-9份、玄参10-15份、大黄2-8份、三七7-15份、枳实4-15份、白头翁3-10份、败酱草5-15份以及竹叶15-20份。
所述药物还包括蝶毛菌3-9份,所述药物还包括荷叶20-25份。
药物制备方法,包括如下步骤:
S1:取菊花15-20份、当归15-20份、夏枯草15-20份、公英20-25份、黄芪20-25份、黄精15-20份、肉桂20-25份、黄芩3-10份、丹参4-10份、玄参10-15份、大黄2-8份、白头翁3-10份、败酱草5-15份、蝶毛菌3-9份以及竹叶15-20份置于粉碎机粉碎,置于煎锅中文火煎制得到混合液A;
S2:取赤芍3-9份,三七7-15份,枳实4-15份,放入砂锅中,用水浸没,加热至60-80°C,蒸煮1-3小时,加入2份酒石酸钠,蒸煮6-8小时,降温至室温,静置3-5小时,过滤得混合液B,蒸干制成粉末B;
S3:将粉末B加入到混合液A中文火煎熬,加入荷叶20-25份,煎熬2-4小时后静置冷却得到混合液C,加入0.1-0.4份酵母发酵液,置于25-35°C的条件下发酵3-6天,加入3-5倍重量份数的水回流提取3次,合并得到混合液D,
S4:蒸干混合液D制成粉末D,装入胶囊制成。
所述粉末D研磨至粒径0.02-0.05mm。
实施例1:S1:取菊花15份、当归15份、夏枯草15份、公英20份、黄芪20份、黄精15份、肉桂20份、黄芩3份、丹参4份、玄参10份、大黄2份、白头翁3份、败酱草5份、蝶毛菌3份以及竹叶15份置于粉碎机粉碎,置于煎锅中文火煎制得到混合液A;
S2:取赤芍3份,三七75份,枳实4份,放入砂锅中,用水浸没,加热至60°C,蒸煮1小时,加入2份酒石酸钠,蒸煮6小时,降温至室温,静置3小时,过滤得混合液B,蒸干制成粉末B;
S3:将粉末B加入到混合液A中文火煎熬,加入荷叶20份,煎熬2小时后静置冷却得到混合液C,加入0.1份酵母发酵液,置于25C的条件下发酵3天,加入3倍重量份数的水回流提取3次,合并得到混合液D,
S4:蒸干混合液D制成粉末D,装入胶囊制成。
所述粉末D研磨至粒径0.02mm。
实施例2:S1:取菊花16份、当归16份、夏枯草16份、公英22份、黄芪22份、黄精16份、肉桂21份、黄芩4份、丹参5份、玄参11份、大黄3份、白头翁4份、败酱草5份、蝶毛菌4份以及竹叶16份置于粉碎机粉碎,置于煎锅中文火煎制得到混合液A;
S2:取赤芍4份,三七8份,枳实5份,放入砂锅中,用水浸没,加热至70°C,蒸煮2小时,加入2份酒石酸钠,蒸煮6小时,降温至室温,静置3小时,过滤得混合液B,蒸干制成粉末B;
S3:将粉末B加入到混合液A中文火煎熬,加入荷叶20份,煎熬2小时后静置冷却得到混合液C,加入0.1份酵母发酵液,置于25C的条件下发酵3天,加入3倍重量份数的水回流提取3次,合并得到混合液D,
S4:蒸干混合液D制成粉末D,装入胶囊制成。
所述粉末D研磨至粒径0.02mm。
实施例3:S1:取菊花17份、当归18份、夏枯草18份、公英24份、黄芪23份、黄精117份、肉桂20-25份、黄芩5份、丹参6份、玄参13份、大黄4份、白头翁5份、败酱草8份、蝶毛菌5份以及竹叶17份置于粉碎机粉碎,置于煎锅中文火煎制得到混合液A;
S2:取赤芍3-9份,三七9份,枳实10份,放入砂锅中,用水浸没,加热至80°C,蒸煮3小时,加入2份酒石酸钠,蒸煮7小时,降温至室温,静置4小时,过滤得混合液B,蒸干制成粉末B;
S3:将粉末B加入到混合液A中文火煎熬,加入荷叶24份,煎熬2小时后静置冷却得到混合液C,加入0.3份酵母发酵液,置于25°C的条件下发酵3-6天,加入4倍重量份数的水回流提取3次,合并得到混合液D,
S4:蒸干混合液D制成粉末D,装入胶囊制成。
所述粉末D研磨至粒径0.023mm。
以上显示和描述了本发明的基本原理和主要特征和本发明的优点,对于本领域技术人员而言,显然本发明不限于上述示范性实施例的细节,而且在不背离本发明的精神或基本特征的情况下,能够以其他的具体形式实现本发明。因此,无论从哪一点来看,均应将实施例看作是示范性的,而且是非限制性的,本发明的范围由所附权利要求而不是上述说明限定,因此旨在将落在权利要求的等同要件的含义和范围内的所有变化囊括在本发明内。不应将权利要求视为限制所涉及的权利要求。
此外,应当理解,虽然本说明书按照实施方式加以描述,但并非每个实施方式仅包含一个独立的技术方案,说明书的这种叙述方式仅仅是为清楚起见,本领域技术人员应当将说明书作为一个整体,各实施例中的技术方案也可以经适当组合,形成本领域技术人员可以理解的其他实施方式。
Claims (5)
1.一种治疗脓毒症的药物,其特征在于由以下重量份数的原料制成:菊花15-20份、当归15-20份、夏枯草15-20份、公英20-25份、黄芪20-25份、黄精15-20份、肉桂20-25份、黄芩3-10份、丹参4-10份、赤芍3-9份、玄参10-15份、大黄2-8份、三七7-15份、枳实4-15份、白头翁3-10份、败酱草5-15份以及竹叶15-20份。
2.根据权利要求1所述的一种治疗脓毒症的药物,其特征在于:所述药物还包括蝶毛菌3-9份。
3.根据权利要求1所述的一种治疗脓毒症的药物,其特征在于:所述药物还包括荷叶20-25份。
4.根据权利要求1所述的药物制备方法,其特征在于包括如下步骤:
S1:取菊花15-20份、当归15-20份、夏枯草15-20份、公英20-25份、黄芪20-25份、黄精15-20份、肉桂20-25份、黄芩3-10份、丹参4-10份、玄参10-15份、大黄2-8份、白头翁3-10份、败酱草5-15份、蝶毛菌3-9份以及竹叶15-20份置于粉碎机粉碎,置于煎锅中文火煎制得到混合液A;
S2:取赤芍3-9份,三七7-15份,枳实4-15份,放入砂锅中,用水浸没,加热至60-80°C,蒸煮1-3小时,加入2份酒石酸钠,蒸煮6-8小时,降温至室温,静置3-5小时,过滤得混合液B,蒸干制成粉末B;
S3:将粉末B加入到混合液A中文火煎熬,加入荷叶20-25份,煎熬2-4小时后静置冷却得到混合液C,加入0.1-0.4份酵母发酵液,置于25-35°C的条件下发酵3-6天,加入3-5倍重量份数的水回流提取3次,合并得到混合液D,
S4:蒸干混合液D制成粉末D,装入胶囊制成。
5.根据权利要求4所述的一种治疗脓毒症的药物及其制备方法,其特征在于:所述粉末D研磨至粒径0.02-0.05mm。
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