CN108272683A - A kind of biological enzyme processing and corrosion-resistant moisturizing plant extraction liquid and the preparation method and application thereof - Google Patents
A kind of biological enzyme processing and corrosion-resistant moisturizing plant extraction liquid and the preparation method and application thereof Download PDFInfo
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- CN108272683A CN108272683A CN201810279058.2A CN201810279058A CN108272683A CN 108272683 A CN108272683 A CN 108272683A CN 201810279058 A CN201810279058 A CN 201810279058A CN 108272683 A CN108272683 A CN 108272683A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
The present invention provides a kind of biological enzyme processing and corrosion-resistant moisturizing plant extraction liquid and the preparation method and application thereof.The method is as follows：Raw material centella, chamomile and Radix Glycyrrhizae are pre-processed to obtain mixed plant piece；Mixed plant piece obtained is placed in 20~45 DEG C of soak and is impregnated 15~30 minutes, soak includes 5~10 parts of the first enzyme preparation, 1~5 part of alcohols material, 1~5 part of salts substances and 40~100 parts of water；Plant piece by soak and after impregnating is ultrasonically treated 1~2 hour under preset temperature, isolated supernatant after static layering；Supernatant heating is cooled to after room temperature and compounds itself and the second enzyme preparation to obtain mixed liquor using ultrasonic wave；Mixed liquor removes impurity, eluent, that is, moisturizing plant extraction liquid of acquisition using the chromatography column pure water elution for being filled with resin extender.Moisturizing plant extraction liquid provided by the invention is mildly non-stimulated, and moistening effect is good, has natural anticorrosion performance.
Description
【Technical field】
The present invention relates to Enzymatic Extraction active material technical field more particularly to a kind of biological enzyme processing and corrosion-resistant guarantor
Wet plant extraction liquid and the preparation method and application thereof.
【Background technology】
Centella (Centella asiatica (L.) Urban) is Umbelliferae centella plant, because its leaf exactly likes horseshoe
Shape or half of copper coin, so also known as membranaceous marshmarigold herb, Longtube Ground Ivy Herb etc., it is civil also to there is place to be called pennyroyal mint, marchantia grass etc..Centella
Applicating history in the traditional medicine field of many countries and regions is long, and China's traditional Chinese medicine is to for oral administration and outer of centella
With existing bimillennium history, quilt earliest《Sheng Nong's herbal classic》One book is contained.According to《Compendium of Materia Medica》It records, centella bitter, pungent, property
It is cold, it is nontoxic, return liver,spleen,kidney, stomach, effect is promoting blood circulation, swelling and pain relieving, and have clearing heat and detoxicating, diuresis etc..The change of centella
Studying a point master has triterpenes, flavonoids, polyyne alkenes and volatile oil etc..
Chamomile (Matricaria chamomillaL.) is also known as german chamomile, is the one of matricaria chamomilla category (Matricaria)
Year is raw or perennial herb, herb fragrance have the function of moisturizing, sterilization, moisturizing whitening etc., are one containing volatile aromatic oil
The spice berry of the great Development volue of kind.
Radix Glycyrrhizae (Glycyrrhiza) also known as Ural Gan Chang, herbaceos perennial belong to pulse family.Physiology in Radix Glycyrrhizae is lived
Property ingredient mainly has triterpene compound (glycyrrhizin also glycyrrhetate, enoxolone etc.), flavone compound (Radix Glycyrrhizae Huang alkali
Ketone, isoliquiritigenin, glycyrrhizin etc.) and licorice polysaccharide class compound three categories ingredient.
Single plant extraction liquid effect cannot fully meet the market demand at present, how perform to plant is both effectiveness most
Greatly, various plants compound the research and development application of extract and give birth to.
【Invention content】
The purpose of the present invention is to provide it is a kind of with biological enzyme processing and corrosion-resistant moisturizing plant extraction liquid method, with gram
Take not strong extract moisture retention caused by prior art organic solvent extraction, safety and both effectiveness not high technological deficiency.
In order to achieve the above objectives, the present invention provides a kind of preparation method of moisturizing plant extraction liquid, the preparation method packet
Include following steps：
(1) 10~80 parts of centellas of raw material, 10~80 parts of chamomiles and 10~80 portions of Radix Glycyrrhizaes are pre-processed to obtain length small
In the mixed plant piece of preset value；
(2) mixed plant piece made from step (1) is placed in 20~45 DEG C of soak and is impregnated 15~30 minutes, it is described
Soak includes 5~10 parts of the first enzyme preparation, 1~5 part of alcohols material, 1~5 part of salts substances and 40~100 parts of water,
In, first enzyme preparation is the mixed of one or more of cellulase, pectase, zytase and hemicellulase
Object is closed, the alcohols material is the mixture of one or more of 1,2- hexylene glycols, butanediol, propylene glycol, pungent glycol,
The salts substances are the mixture of one or more of sodium chloride, potassium chloride, magnesium chloride, sodium carbonate；
(3) the mixed plant piece by soak and after impregnating is transferred in processor for ultrasonic wave, ultrasonic at 20~45 DEG C
Processing 1~2 hour, isolated supernatant after static layering；
(4) supernatant is heated 5~15 minutes at 85~100 DEG C, after being cooled to room temperature, adds 5~10
Second enzyme preparation of part, and be ultrasonically treated 1~2 hour at 20~45 DEG C and obtain mixed liquor, wherein the second enzyme preparation packet
Include glucose oxidase and/or lysozyme；
(5) mixed liquor removes impurity, acquisition is washed using the chromatography column pure water elution for being filled with resin extender
De- liquid, that is, moisturizing plant extraction liquid.
In one preferred embodiment of preparation method of the moisturizing plant extraction liquid of the preservative free provided by the invention,
The weight ratio of the centella, the chamomile and the Radix Glycyrrhizae is (0.25~2)：(0.5~8)：1.
In one preferred embodiment of preparation method of the moisturizing plant extraction liquid provided by the invention, the accumulated snow
The weight ratio of careless, the described chamomile and the Radix Glycyrrhizae is 1：1：1.
In one preferred embodiment of preparation method of the moisturizing plant extraction liquid provided by the invention, the second enzyme
Preparation further includes Co-Q10 or protease.
Present invention simultaneously provides a kind of with biological enzyme processing and corrosion-resistant moisturizing plant extraction liquid, the moisturizing plant extract
Liquid is prepared using the preparation method of moisturizing plant extraction liquid described above.
The present invention also provides it is a kind of it is described above with biological enzyme processing and corrosion-resistant moisturizing plant extraction liquid in preparationization
Application in cosmetic and personal care and toiletry.
Be in terms of 100% by its total weight the present invention also provides a kind of moisturizing mildy wash comprising 0.5~15% it is above
The moisturizing plant extraction liquid that the preparation method is prepared.
The present invention also provides a kind of skin-moisturizing, skin breast, by its total weight be 100% in terms of comprising 0.5~15% it is above
The moisturizing plant extraction liquid that the preparation method is prepared.
The present invention also provides a kind of moisture-keeping shower creams, are in terms of 100% by its total weight comprising 1~15% institute above
The moisturizing plant extraction liquid that the preparation method stated is prepared.
The present invention also provides a kind of moisturizing astringents, are in terms of 100% by its total weight comprising 3~18% institute above
The moisturizing plant extraction liquid that the preparation method stated is prepared.
Compared with the relevant technologies, biological enzyme processing and corrosion-resistant moisturizing plant extraction liquid and its preparation provided by the invention
Method has the advantages that with application：
One, moisturizing plant extraction liquid provided by the invention utilizes compound bio using centella, chamomile and Radix Glycyrrhizae as raw material
The peculiar technology extraction active material of enzyme cracks plant comprehensively under the collective effect of the first enzyme preparation, alcohols material and salts substances
The closed structure of object cell wall and cytoplasm, the active material in high efficiency extraction raw material, and avoid and had using virose
Solvent improves the safety of moisturizing plant extraction liquid.
Two, the active material for effectively compounding the second enzyme preparation using ultrasonic wave and being extracted from raw material, makes the moisturizing of preparation
Plant extraction liquid itself has antiseptic property, no longer needs to addition preservative, is on the one hand applied in cosmetics and personal care and toiletry
When on the other hand can also extend the service life of product itself to avoid negative effects such as the stimulations that bring of addition preservative.
Three, moisturizing plant extraction liquid provided by the invention is soluble liquid, overcomes powdered moisturizing extract each
The limitation of compliant applications in class product system, and moisturizing plant extraction liquid provided by the invention is mildly non-stimulated, Neng Gouchang
Imitate moisturizing.
【Specific implementation mode】
The following is a clear and complete description of the technical scheme in the embodiments of the invention, it is clear that described embodiment
Only it is a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, the common skill in this field
All other embodiment that art personnel are obtained without making creative work belongs to the model that the present invention protects
It encloses.
The present invention provides a kind of preparation method with biological processing and corrosion-resistant moisturizing plant extraction liquid, the method includes
Following steps：
Step 1: 10~80 parts of centellas of raw material, 10~80 parts of chamomiles and 10~80 portions of Radix Glycyrrhizaes are pre-processed and are grown
Mixed plant piece of the degree less than preset value；
Specifically, the centella is selected from Guangdong region centella, Hubei Regional centella, Hainan region centella, river
One or more of Red Region domain centella.Preferably, the centella is Guangdong region centella.The chamomile
It is sweet selected from Rome chamomile (CHAMAEMELUM NOBILE), German chamomile (MATRICARIA RECUTICA), Morocco ocean
One or two kinds of mixtures of chrysanthemum (ORMENIS MULTICAULIS).Preferably, the chamomile is Rome chamomile.It is described
Radix Glycyrrhizae is selected from one or more of Guangdong region Radix Glycyrrhizae, Hubei Regional Radix Glycyrrhizae, Hunan region, Hebei region Radix Glycyrrhizae.It is excellent
Selection of land, the Radix Glycyrrhizae are Guangdong region Radix Glycyrrhizae.
Centella, chamomile and Radix Glycyrrhizae are cleaned up, little block is cut into, then reuses crusher machine of squeezing the juice, after being crushed
Each raw material length be less than 8mm, i.e., by the length of the broken mixed plant piece of juice extractor be less than 8mm.It needs to illustrate
It is that centella, chamomile and Radix Glycyrrhizae can be remixed with crusher machine of squeezing the juice respectively, or by centella, chamomile before broken
It mixes with Radix Glycyrrhizae, is then crushed together again.Also different to the degree of crushing of raw material using the juice extractor of different model, 8mm is
Preferred value.
Preferably, the weight ratio of the centella, the chamomile and the Radix Glycyrrhizae is (0.25~2)：(0.5~8)：
1。
Preferably, the weight ratio of the centella, the chamomile and the Radix Glycyrrhizae is 1:1:1、1:2:1、1:4:1、
1:6:1、1:8:1、2:1:1、4:1:2、6:1:2 and 8:1:2.
It is further preferable that the weight ratio of the chamomile, the honeysuckle flowers and the sweet clover is 1：1：1.
It is impregnated 15~30 minutes Step 2: mixed plant piece made from step 1 is placed in 20~45 DEG C of soak,
The soak includes 5~10 parts of the first enzyme preparation, 1~5 part of alcohols material, 1~5 part of salts substances and 40~100 parts of water,
Wherein, first enzyme preparation is one or more of cellulase, pectase, zytase and hemicellulase
Mixture, the alcohols material are the mixing of one or more of 1,2- hexylene glycols, butanediol, propylene glycol, pungent glycol
Object, the salts substances are the mixture of one or more of sodium chloride, potassium chloride, magnesium chloride, sodium carbonate.
The present invention extracts active material using the peculiar technology of compound biological enzyme, in the first enzyme preparation, alcohols material and salt
Under the collective effect of substance, the closed structure of plant cell wall and cytoplasm, high efficiency extraction centella, chamomile are cracked comprehensively
It with the active material of Radix Glycyrrhizae, and avoids using virose organic solvent, improves the safety of moisturizing plant extraction liquid.
Preferably, first enzyme preparation is the mixture of the cellulase, the pectase and the zytase,
And the weight ratio group of the zytase, the cellulase and the pectase sum becomes 1：(2~8)：(1~6).
Wherein, cellulase can make the mass degradations such as cellulose, pectin in cell wall or cytoplasm with pectase,
The compact texture for destroying cell wall causes cell wall and cytoplasm structure to generate the variations such as loose part, expansion, collapse, subtracts
The resistance to mass tranfer that the mass transfers such as cellule wall, cytoplasm barrier spreads active ingredient from intracellular to Extraction medium, from mass transfer angle
Degree promotes effective component extraction rate to improve.
Xylan is the important component of plant hemicellulose, and xylan is complicated, the degradable ginseng for needing a variety of enzymes
With, and zytase is to participate in most important one kind in degradation enzyme system.Xylan refer to can by xylan degrading at oligosaccharide and
The general name of one group of enzyme of xylose, zytase can be crushed plant cell wall, improve nutrient xylan degrading be the degree of polymerization compared with
Low small molecule segment destroys the structure of cell wall, and the nutriment that cell wall fetters is released.
Hemicellulase is that a kind of polysaccharide (except cellulose and pectin substance) that can make composition plant cell membrane hydrolyzes
Enzyme.
Wherein, 1,2- hexylene glycols, butanediol, propylene glycol and pungent glycol can dissolve certain plant ingredient, simultaneously
Safety is good, has respective good characteristic.Such as 1,2- hexylene glycols, can efficiently permanent moisturizing, also have the work(of antisepsis and sterilization
Effect；Butanediol sense of touch is smooth, and property is stablized, and more soft skin sense can be obtained；The viscosity and good hygroscopicity of propylene glycol, it is nontoxic；
Pungent glycol has certain moisturizing and antibacterial activity.
Preferably, the alcohols material is 1,2- hexylene glycols.
Wherein, sodium chloride can increase the viscosity of system；Osmolyte regulator, salting-out agents can be done, are had to the activity of enzyme certain
Influence, influence the dissolution that enzyme cracks substance in the speed and plant cell of cell wall.The sodium chloride also work with bactericidal antiphlogistic
With.
Potassium chloride is one kind of hydrochloride, white crystals or crystalline powder, and soluble easily in water and glycerine is insoluble in alcohol, no
It is dissolved in ether and acetone.In the food industry, it can be used as salt substitute applied to agricultural production, aquatic products, livestock products, fermentation, seasoning, tank
Head, instant food etc. make low Na prod, to reduce the excessively high harmful effect to body of sodium content；It is also used for strengthening potassium (for people
Body electrolyte use), prepare sports drink etc..
Magnesium chloride is important inorganic raw material in chemical industry, for producing the magnesium such as magnesium carbonate, magnesium hydroxide, magnesia
Product also serves as the raw material etc. of antifreezing agent.Food additives, protein coagulation agent, deicing salt, freezing can be done in other fields
Agent, dust-proofing agent, refractory material etc..
Sodium carbonate is a kind of white powder soluble easily in water, solution alkaline.It is widely used in medicine, papermaking, metallurgy, glass
The industry such as glass, weaving, dyestuff are used as food industry leavening.
Preferably, the salts substances are sodium chloride.
Step 3: the mixed plant piece by soak and after impregnating is transferred in processor for ultrasonic wave, at 20~45 DEG C
It is ultrasonically treated 1~2 hour, isolated supernatant after static layering；Wherein, separation method can be centrifugation or filtering.
Under normal circumstances, in order to reduce the preparation process time, the temperature of supersound process is identical with the temperature of immersion.
Step 4: the supernatant is heated 5~15 minutes at 85~100 DEG C, after being cooled to room temperature, 5 are added
~10 parts of the second enzyme preparation, and be ultrasonically treated 1~2 hour at 20~45 DEG C and obtain mixed liquor, wherein the second enzyme system
Agent includes glucose oxidase and/or lysozyme；
Preferably, second enzyme preparation further includes Co-Q10 or protease.
Second enzyme preparation is both effectiveness enzyme preparation, and glucose oxidase and lysozyme can inhibit bacterial plaque to be formed, can effectively go
Degerming planting group makes the moisturizing plant extraction liquid itself of extraction have antiseptic property, extends the service life of product, and avoids adding
Entering other preservatives makes generation allergic phenomena.The effect of it is in application can be improved in Co-Q10 and protease.
Specifically：
Glucose oxidase effectively fast decoupled glucan, dissolving bacterial plaque can inhibit bacterial plaque to be formed, can effectively remove bacterium colony
Population.
Lysozyme is a kind of alkaline enzyme that can be hydrolyzed and stick polysaccharide in pathogenic bacteria.Mainly by destroying the N- acetyl in cell wall
β-Isosorbide-5-Nitrae glycosidic bond between muramic acid and n-acetylglucosamine makes the insoluble glutinous polysaccharide of cell wall resolve into soluble glycopeptide,
Cell wall rupture content is caused to escape and make bacterolysis.Lysozyme can also be bound directly with negatively charged virus protein,
Double salt is formed with DNA, RNA, apoprotein, makes virally inactivated, therefore, which has the effects that antibacterial, anti-inflammatory, antiviral.
Lysozyme is safe as preservative.Lysozyme is a kind of native protein, and property is very stable.
Co-Q10 is a kind of fat-soluble antioxidant, and the nutrition of energy human activin cell and cellular energy has and improves people
Body immunity enhances the functions such as anti-oxidant, anti-aging and enhancing human activity.Can go deep into cell simultaneously, strengthen cell newly at
On the other hand metabolic function, consolidation binding ability between Polygonum Multiflorum Thunb Extract form the reticular structure of elasticity in epidermis, repair really because
Wrinkle caused by fluid loss characteristics, and reach real moisture-keeping efficacy in turn.
Step 5: the mixed liquor is removed impurity, is obtained using the chromatography column pure water elution for being filled with resin extender
Eluent, that is, moisturizing plant extraction liquid.
The present invention also provides using the preparation side described above with biological enzyme processing and corrosion-resistant moisturizing plant extraction liquid
What method was prepared is processed with biological enzyme can make up with corrosion-resistant moisturizing plant extraction liquid, the moisturizing plant extraction liquid preparing
It is applied in product and personal care and toiletry.
The invention further particularly discloses tool of the moisturizing plant extraction liquid in facial cleanser, milky lotion, shower cream and toner
Body application.The technical solution of specific implementation is as follows：
Be in terms of 100% by its total weight using a kind of 1, moisturizing mildy wash comprising 0.5~15% it is described above
The moisturizing plant extraction liquid that preparation method is prepared.
Preferably, the moisturizing mildy wash includes following component by weight percentage：Lauric alcohol sulfuric ester sodium salt
2.5%~3.5%, coconut oleoyl amine 2.0%~3.5%, moisturizing plant extraction liquid 0.5%~15%, citric acid 0.01%~
0.05%, surplus is deionized water.
It is highly preferred that the moisturizing mildy wash includes following component by weight percentage：Lauric alcohol sulfuric ester sodium salt
2.5%, coconut oleoyl amine 3.5%, moisturizing plant extraction liquid 8.0%, citric acid 0.03%, deionized water 85.97%.
Using a kind of 2, skin-moisturizing, skin breast, by its total weight be 100% in terms of comprising 0.5~15% it is described above
The moisturizing plant extraction liquid that preparation method is prepared.
Preferably, the skin-moisturizing, skin breast includes following component by weight percentage：Butanediol 2.5%~3.5%,
Gluconic acid sodium salt 0.005%~0.01%, caprylic/capric triglyceride 2.0%~3.5%, Parleam 2.0%~
3.0%, isononyl isononanoate 0.5%~1.5%, cetostearyl alcohol 0.1%~0.8%, polyacrylate cross-linked polymer -6
0.2%~0.8%, polysorbate -60 0.015%~0.07%, the tert-butyl alcohol 0.0025%~0.01%, moisturizing plant carry
It is deionized water to take liquid 0.5%~15%, citric acid 0.01%~0.05%, surplus.
It is highly preferred that the skin-moisturizing, skin breast includes following component by weight percentage：Butanediol 3.0%, glucose
Sour sodium 0.008%, caprylic/capric triglyceride 3.5%, Parleam 2.0%, isononyl isononanoate 0.5%, spermaceti are hard
Lipidol 0.8%, polyacrylate cross-linked polymer -6 0.4%, polysorbate -60 0.05%, the tert-butyl alcohol 0.01%, moisturizing
Plant extraction liquid 8%, citric acid 0.03%, deionized water 81.702%.
It is in terms of 100% by its total weight comprising 1~15% system described above using a kind of 3, moisture-keeping shower cream
The moisturizing plant extraction liquid that Preparation Method is prepared.
Preferably, the moisture-keeping shower cream includes following component by weight percentage：Cocoamidopropyl betaine
4.5%~6.5%, lauryl glucoside 2.0%~3.0%, Plantacare 818 0.15%~0.2%, cocounut oil acyl both sexes base two
Acetic acid disodium 0.005%~0.01%, PEG-150 distearates 2.0%~3.5%, PEG-7 glyceryl cocoates 2.0%
~3.0%, moisturizing plant extraction liquid 1.0%~15.0%, citric acid 0.01%~0.05%, surplus are deionized water.
It is highly preferred that the moisture-keeping shower cream includes following component by weight percentage：Cocamidopropyl propyl amide beet
Alkali 5.0%, lauryl glucoside 2.0%, Plantacare 818 0.15%, cocounut oil acyl both sexes base diethyl acid disodium 0.01%, PEG-
150 distearates 2.0%, moisturizing plant extraction liquid 5.0%, citric acid 0.01%, are gone PEG-7 glyceryl cocoates 2.0%
Ionized water 83.83%.
It is in terms of 100% by its total weight comprising 3~18% system described above using a kind of 4, moisturizing astringent
The moisturizing plant extraction liquid that Preparation Method is prepared.
Preferably, the moisturizing astringent includes following component by weight percentage：Glycerine 1.0%~2.5% is protected
Wet plant extraction liquid 3.0%~18%, butanediol 0.8%~2%, PEG-60 rilanit specials 0.2%~1.0%, essence
0.05%~0.2%, citric acid 0.01%~0.05%, surplus are deionized water.
It is highly preferred that the moisturizing astringent includes following component by weight percentage：Glycerine 1.0%, moisturizing are planted
Object extracting solution 16%, butanediol 2%, PEG-60 rilanit specials 0.2%, essence 0.1%, citric acid 0.05%, deionized water
80.65%.
One, moisturizing plant extraction liquid (embodiment 1-9) is prepared
Embodiment 1
10 parts of centellas, 10 parts of chamomiles and 10 portions of Radix Glycyrrhizaes are cleaned up, after being cut into little block, mixing, using squeezing the juice
Crusher machine；Then 100 parts of water, 7 part of first enzyme preparation (2.5 parts of cellulase, 2 parts of pectase, 2.5 parts of zytase), 5 are added
Part alcohols material (1,2- 5 parts of hexylene glycol), 5 parts of salts substances (5 parts of sodium chloride) are placed in 25 DEG C of thermostatic water-baths and impregnate
30min；It is transferred in processor for ultrasonic wave after immersion, to continue ultrasound 1h at a temperature of 25 DEG C；Be then allowed to stand layering, centrifugation or
Supernatant is obtained by filtration；Supernatant is heated into 10min at 90 DEG C again, after supernatant is cooled to room temperature, is added 5.5 part second
Enzyme preparation (2 parts of glucose oxidase, 3.5 parts of lysozyme), continuation ultrasound 1h obtains mixed liquor at 25 DEG C；Finally by the mixing
Liquid is washed with water by being filled with the chromatography column of resin extender, to remove impurity, collects eluent and planted to get to moisturizing
Object extracting solution.
In embodiment 1, the weight ratio of centella, chamomile and Radix Glycyrrhizae is 1：1：1, embodiment 2~9 remove by centella,
Other than the weight ratio of chamomile and Radix Glycyrrhizae changes as shown in table 1, under the conditions of other are all same with embodiment 1 into
It goes and moisturizing plant extraction liquid is prepared, the weight ratio of each raw material is as follows in embodiment 2~9：
Table 1
Two, embodiment provides in order to further illustrate the present invention the safety of moisturizing plant extraction liquid and both effectiveness, with
The advantageous effect of the moisturizing plant extraction liquid of embodiment offer is be provided by test example down：
Experiment one：Moistening effect is tested
Laboratory sample：The moisturizing plant extraction liquid that the embodiment of the present invention 1~9 provides
Experimental method：With skinanalysis apparatus measure fixing arm initial parameter index initial value (moisture content, oil content, elasticity,
Collagenous fibres etc.), the moisturizing plant extraction liquid of equivalent is smeared, is smeared uniformly, waits for fully absorbed to skin within 1 minute, test applies
Smear each parameter index value at rear fixing arm.
Table 2
| Test specimen | Moisture content initial value | After smearing 1min | After smearing 30min | After smearing 1h |
| Embodiment 1 | 40% | 66% | 66% | 65% |
| Embodiment 2 | 41% | 63% | 63% | 64% |
| Embodiment 3 | 42% | 62% | 62% | 60% |
| Embodiment 4 | 39% | 63% | 63% | 62% |
| Embodiment 5 | 41% | 60% | 59% | 59% |
| Embodiment 6 | 45% | 66% | 65% | 66% |
| Embodiment 7 | 42% | 67% | 55% | 56% |
| Embodiment 8 | 40% | 59% | 58% | 57% |
| Embodiment 9 | 41% | 60% | 60% | 59% |
This experiment carried out moisture-keeping efficacy to the moisturizing plant extraction liquid in the present invention using skinanalysis apparatus and tested, this hair
Bright moisturizing plant extraction liquid compounds, Neng Gouyou using centella, chamomile, Radix Glycyrrhizae as raw material under the action of a variety of enzymes
Effect and long-acting moisturizing.It is found through experiments that the moisturizing plant extraction liquid of the present invention can obviously increase the moisture of skin, increases flesh
The water humidity of skin keeps the soft and smooth water of skin tender, and moisture value added is 20% or more；After absorbing 1h, the moisture of skin increases
Value is kept essentially constant, being capable of long-acting moisturizing.The moisture-keeping efficacy for the moisturizing plant extraction liquid that the embodiment of the present invention 1 provides
Preferably, the ratio between number of centella, chamomile and Radix Glycyrrhizae is 1:1:1, it the results are shown in Table 2.
Experiment two：Preservative efficacy testing
1, test specimen：The moisturizing plant extraction liquid sample that the embodiment of the present invention 1 provides；Experimental bacteria is Escherichia coli ATCC
25922, staphylococcus aureus ATCC 6538, pseudomonas aeruginosa ATCC 9027, Candida albicans ATCC 10231.
2, test method：Microbiology challenge test method.
3, result evaluation：Using《European Pharmacopoeia》Result evaluation standard this test result is evaluated, have
Body refers to the following table 3.
Table 3
From the test result of upper table 3 it is found that 4 kinds of experimental bacterias (1 week) total plate count when the 7th day declines 100%, until the
It is tested by challenge without growth, judgement at 28 days, inhibitor effectiveness is good, i.e., the antiallergic that the embodiment of the present invention 1 provides is compound
Extracting solution is good using the anti-corrosion effect of the protective system of lysozyme, glucose oxidase and polyalcohol compounding structure.
Experiment three：Ocular irritation/erosion test
1, test specimen：The moisturizing plant extraction liquid that the embodiment of the present invention 1~9 provides.
2, test method：SN/T 2329-2009 cosmetics eye irritation/corrosive chick chorioallantoic membrane experiment.
3, evaluation of test result standard：Stimulation standards of grading are divided into following level：IS ＜ 1 are nonirritant；1≤IS ＜ 5
For subexcite；5≤IS ＜ 9 are moderate irritation；IS >=10 are strong and stimulating/corrosivity.
4, test result：Through overtesting, the stimulation scoring of moisturizing plant extraction liquid of the invention is IS ＜ 1, i.e. this hair
The moisturizing plant extraction liquid that bright embodiment provides is mildly nonirritant to eye.
Experiment four：Skin irritation test
(1) skin closure type patch test
1, test specimen：The moisturizing plant extraction liquid that the embodiment of the present invention 1~9 provides.
2, test method：From 20 volunteers of a certain regional choice, the age of volunteer, body was strong between 20~45 years old
Health, in the recent period non-drug administration, nonbreast-fed women or gravid woman, non-constitution sensitive subjects.Volunteer is divided into 10 groups at random,
Every group of two people.Wherein, group 1 is blank control group, and the small interior of spot examination device does not place any substance, spot is tried the low sensitization glue of device
Band is pasted on the back of volunteer or forearm bends side, is gently pressed with palm and is allowed to equably stick on the skin；Group 2~groups 10 with
The processing method of group 1 is identical, unlike：Spot will be put into added with 0.025mL moisturizing plant extraction liquids provided by the invention respectively
Try the small interior of device；I.e. group 2 it is corresponding be embodiment 1 provide moisturizing plant extraction liquid, group 3 it is corresponding be the embodiment of the present invention 2
The moisturizing plant extraction liquid of offer, the corresponding moisturizing plant extraction liquid ... for being the offer of the embodiment of the present invention 3 of group 4 is with such
Push away, group 10 it is corresponding be the embodiment of the present invention 9 provide moisturizing plant extraction liquid.After each group test duration 24 hours, 48 hours,
30min observes the response situation and record for sticking place's skin after impression disappearance after removing spot examination device.
Wherein, skin closure type patch test dermoreaction grade scale see the table below 4.
Table 4
During entire experiment, the subject's of group 1~groups 10 is reacted negative by gesture area skin.Thus
As can be seen that moisturizing plant extraction liquid provided in an embodiment of the present invention will not cause the allergy and stimulate the reaction of skin, safety
It is good.
(2) repeatability is opening smears experiment
1, test specimen：The moisturizing plant extraction liquid that the embodiment of the present invention 1~9 provides.
2, from a certain region select 20 volunteers, the age of volunteer between 20-45 Sui, health, in the recent period
Non- drug administration, nonbreast-fed women or gravid woman, non-constitution sensitive subjects.Volunteer is divided into 10 groups, every group two at random
It is personal.Wherein, group 1 is blank control group, is bent using forearm as recipient site, 3 × 3cm2 of area, and recipient site keeps drying,
It avoids contact with before tested and during by gesture other external preparations, with ultra-pure water 0.05 ± 0.005g/ times, equably smears tested portion
Position；Group 2~groups 10 are respectively test group, unlike group 1：The moisturizing plant extract provided using the embodiment of the present invention 1~9
Liquid 0.05 equably smears recipient site ± 0.005g/ times；Wherein, i.e., it is that the moisturizing plant that embodiment 1 provides carries that group 2 is corresponding
Take liquid, it is moisturizing plant extraction liquid that the embodiment of the present invention 2 provides that group 3 is corresponding, and corresponding group 4 is that the embodiment of the present invention 3 carries
The moisturizing plant extraction liquid ... of confession, it is moisturizing plant extraction liquid that the embodiment of the present invention 9 provides that group 10 is corresponding.
Each group carries out 2 times and equably smears recipient site daily, and long run test completes experiment, observes the tested of subject daily after 7 days
The dermoreaction situation at position simultaneously records.During experiment, if there is 3 points or more of dermoreaction in such as the following table 5
When situation, it can stop continuing to test and record result.
Wherein, table 5 is that opening smear of skin repeatability tests dermoreaction judgment criteria table.
Table 5
During entire experiment, the dermoreaction by gesture position of the subject of group 1~groups 10 is negative.By
This, which can be seen that moisturizing plant extraction liquid provided in an embodiment of the present invention, will not cause the allergy and stimulate the reaction of skin, safety
Property is good.
Three, Application Example 10
The application of moisturizing plant extraction liquid prepared by embodiment 1 in moisturizing mildy wash
Table 6
Table 7
Table 8
Table 6 is application of the moisturizing plant extraction liquid of the present invention in facial cleanser.Moisturizing plant extraction liquid has natural
Antiseptic property adds in formula system, can substitute preservative and play antisepsis, be not necessarily to add anti-corrosion in formula system
Agent.By the result of table 7 it is found that facial cleanser formula 1~5 is tested by preservation challenge；Meanwhile facial cleanser is formulated 1~5 pair
The moisture that skin can be obviously increased increases the water humidity of skin, keeps the soft and smooth water of skin tender, and moisture increases peak and reaches
15%；Absorb 1h after, the moisture value added of skin is kept essentially constant, can long-acting moisturizing, the results are shown in Table 8.
Four, Application Example 11
The application of moisturizing plant extraction liquid prepared by embodiment 1 in skin-moisturizing, skin breast
Table 9
Table 10
| Formula 1 | Formula 2 | Formula 3 | Formula 4 | Formula 5 | |
| Whether tested by preservation challenge | Pass through | Pass through | Pass through | Pass through | Pass through |
Table 11
| Test specimen | Moisture content initial value | After smearing 1min | After smearing 30min | After smearing 1h |
| Formula 1 | 40% | 58% | 58% | 58% |
| Formula 2 | 41% | 52% | 52% | 52% |
| Formula 3 | 42% | 52% | 52% | 52% |
| Formula 4 | 39% | 55% | 55% | 55% |
| Formula 5 | 41% | 49% | 49% | 49% |
Table 9 is application of the moisturizing plant extraction liquid of the present invention in milky lotion.Moisturizing plant extraction liquid has natural
Antiseptic property adds in formula system, can substitute preservative and play antisepsis, be not necessarily to add anti-corrosion in formula system
Agent.By the result of table 10 it is found that milky lotion formula 1~5 is tested by preservation challenge；Meanwhile milky lotion formula 1~5
To the moisture of skin can be obviously increased, increases the water humidity of skin, keep the soft and smooth water of skin tender, moisture increases peak and reaches
18%；Absorb 1h after, the moisture value added of skin is kept essentially constant, can long-acting moisturizing, the results are shown in Table 11.
Five, Application Example 12
The application of moisturizing plant extraction liquid prepared by embodiment 1 in moisture-keeping shower cream
Table 12
Table 13
| Formula 1 | Formula 2 | Formula 3 | Formula 4 | Formula 5 | |
| Whether tested by preservation challenge | Pass through | Pass through | Pass through | Pass through | Pass through |
Table 14
Table 12 is application of the moisturizing plant extraction liquid of the present invention in shower cream.Moisturizing plant extraction liquid has natural
Antiseptic property adds in formula system, can substitute preservative and play antisepsis, by the result of table 13 it is found that taking a shower
Dew formula 1~5 is tested by preservation challenge；Meanwhile the moistening effect of formula of bath cream 1~5 is good, can significantly improve skin
Moisture, up to 10% or more, and can long-acting moisturizing, nourish skin, the results are shown in Table 14.
Six, Application Example 13
The application of moisturizing plant extraction liquid prepared by embodiment 1 in moisturizing astringent
Table 15
Table 16
| Formula 1 | Formula 2 | Formula 3 | Formula 4 | Formula 5 | |
| Whether tested by preservation challenge | Pass through | Pass through | Pass through | Pass through | Pass through |
Table 17
| Test specimen | Moisture content initial value | After smearing 1min | After smearing 30min | After smearing 1h |
| Formula 1 | 40% | 58% | 58% | 58% |
| Formula 2 | 41% | 56% | 56% | 56% |
| Formula 3 | 42% | 58% | 58% | 58% |
| Formula 4 | 39% | 61% | 61% | 61% |
| Formula 5 | 41% | 55% | 55% | 55% |
Table 15 is application of the moisturizing plant extraction liquid of the present invention in toner.Moisturizing plant extraction liquid has natural
Antiseptic property adds in formula system, can substitute preservative and play antisepsis, by the result of table 16 it is found that makeup
Water formula 1~5 is tested by preservation challenge；Meanwhile the moistening effect of toner formula 1~5 is good, can significantly improve skin
Moisture, up to 21%, and can long-acting moisturizing, nourish skin, the results are shown in Table 17.
Biological enzyme processing and corrosion-resistant moisturizing plant extraction liquid and the preparation method and application thereof provided by the invention have
Following advantageous effect：
One, moisturizing plant extraction liquid provided by the invention utilizes compound bio using centella, chamomile and Radix Glycyrrhizae as raw material
The peculiar technology extraction active material of enzyme cracks plant comprehensively under the collective effect of the first enzyme preparation, alcohols material and salts substances
The closed structure of object cell wall and cytoplasm, the active material in high efficiency extraction raw material, and avoid and had using virose
Solvent improves the safety of moisturizing plant extraction liquid.
Two, the active material for effectively compounding the second enzyme preparation using ultrasonic wave and being extracted from raw material, makes the moisturizing of preparation
Plant extraction liquid itself has antiseptic property, no longer needs to addition preservative, is on the one hand applied in cosmetics and personal care and toiletry
When on the other hand can also extend the service life of product itself to avoid negative effects such as the stimulations that bring of addition preservative.
Three, moisturizing plant extraction liquid provided by the invention is soluble liquid, overcomes powdered moisturizing extract each
The limitation of compliant applications in class product system, and moisturizing plant extraction liquid provided by the invention is mildly non-stimulated, Neng Gouchang
Imitate moisturizing.
Above-described is only embodiments of the present invention, it should be noted here that for those of ordinary skill in the art
For, without departing from the concept of the premise of the invention, improvement can also be made, but these belong to the protection model of the present invention
It encloses.
Claims (10)
1. a kind of preparation method with biological enzyme processing and corrosion-resistant moisturizing plant extraction liquid, which is characterized in that the preparation side
Method includes the following steps：
(1) 10~80 parts of centellas of raw material, 10~80 parts of chamomiles and 10~80 portions of Radix Glycyrrhizaes are pre-processed to obtain length less than pre-
If the mixed plant piece of value；
(2) mixed plant piece made from step (1) is placed in 20~45 DEG C of soak and is impregnated 15~30 minutes, the immersion
Liquid includes 5~10 parts of the first enzyme preparation, 1~5 part of alcohols material, 1~5 part of salts substances and 40~100 parts of water, wherein institute
The mixture that the first enzyme preparation is one or more of cellulase, pectase, zytase and hemicellulase is stated,
The alcohols material is the mixture of one or more of 1,2- hexylene glycols, butanediol, propylene glycol, pungent glycol, described
Salts substances are the mixture of one or more of sodium chloride, potassium chloride, magnesium chloride, sodium carbonate；
(3) the mixed plant piece by soak and after impregnating is transferred in processor for ultrasonic wave, and 1 is ultrasonically treated at 20~45 DEG C
~2 hours, isolated supernatant after static layering；
(4) supernatant is heated 5~15 minutes at 85~100 DEG C, after being cooled to room temperature, adds 5~10 parts
Second enzyme preparation, and be ultrasonically treated 1~2 hour at 20~45 DEG C and obtain mixed liquor, wherein second enzyme preparation includes Portugal
Carbohydrate oxidase and/or lysozyme；
(5) mixed liquor removes impurity, the eluent of acquisition using the chromatography column pure water elution for being filled with resin extender
That is moisturizing plant extraction liquid.
2. the preparation method according to claim 1 with biological enzyme processing and corrosion-resistant moisturizing plant extraction liquid, feature
It is, the weight ratio of the centella, the chamomile and the Radix Glycyrrhizae is (0.25~2)：(0.5~8)：1.
3. the preparation method according to claim 2 with biological enzyme processing and corrosion-resistant moisturizing plant extraction liquid, feature
It is, the weight ratio of the centella, the chamomile and the Radix Glycyrrhizae is 1：1：1.
4. the preparation method according to claim 1 with biological enzyme processing and corrosion-resistant moisturizing plant extraction liquid, feature
It is, second enzyme preparation further includes Co-Q10 or protease.
5. a kind of biological enzyme processing and corrosion-resistant moisturizing plant extraction liquid, which is characterized in that the moisturizing plant extraction liquid is adopted
It is prepared with the preparation method of moisturizing plant extraction liquid any one of Claims 1-4.
6. application of the moisturizing plant extraction liquid in preparing cosmetics and personal care and toiletry described in claim 5.
7. a kind of moisturizing mildy wash, which is characterized in that by its total weight be 100% in terms of comprising 0.5~15% claim
The moisturizing plant extraction liquid that preparation method described in any one of 1 to 4 is prepared.
8. a kind of skin-moisturizing, skin breast, which is characterized in that by its total weight be in terms of 100% comprising 0.5~15% claim
The moisturizing plant extraction liquid that preparation method described in any one of 1 to 4 is prepared.
9. a kind of moisture-keeping shower cream, which is characterized in that by its total weight be 100% in terms of comprising 1~15% claim 1
The moisturizing plant extraction liquid being prepared to the preparation method described in any one of 4.
10. a kind of moisturizing astringent, which is characterized in that by its total weight be 100% in terms of comprising 3~18% claim 1
The moisturizing plant extraction liquid being prepared to the preparation method described in any one of 4.
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