CN108261473A - The skin disease external prescription and preparation method of a kind of antibacterial anti-inflammatory containing camellia oil - Google Patents

The skin disease external prescription and preparation method of a kind of antibacterial anti-inflammatory containing camellia oil Download PDF

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CN108261473A
CN108261473A CN201611241352.1A CN201611241352A CN108261473A CN 108261473 A CN108261473 A CN 108261473A CN 201611241352 A CN201611241352 A CN 201611241352A CN 108261473 A CN108261473 A CN 108261473A
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China
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parts
camellia oil
skin disease
inflammatory
antibacterial anti
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冯秋瑜
李学坚
郭宏伟
张健
卢奕
覃宇
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Guangxi University of Chinese Medicine
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Guangxi University of Chinese Medicine
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention discloses a kind of skin disease external prescriptions of the antibacterial anti-inflammatory containing camellia oil, are made of the parts by weight of following feed components：300 310 parts of camellia oil, 230 250 parts of rheum officinale, 130 140 parts of Asian puccoon, 200 230 parts of the coptis, 240 280 parts of Radix Isatidis, 340 350 parts of Fructus Forsythiae, 190 260 parts of 250 290 parts of honeysuckle and Herba Andrographitis, the formula and processing technology that the present invention uses are simple, the drug produced can reach good antibacterial anti-inflammatory and treat dermopathic effect, since the camellia oil in formula contains tea polyphenols and the important chemical substance of squalene, tea polyphenols can effectively play the effect of sterilization and anti-inflammatory, squalene can treat nettle rash, the relevant skin disease of eczema, when there is bacterium infection and causes skin disease in people's skin, bactericidal antiphlogistic can be played in a short time using the drug of the present invention, treat dermopathic advantageous effect.

Description

The skin disease external prescription and preparation method of a kind of antibacterial anti-inflammatory containing camellia oil
Technical field
The present invention relates to field of medical technology, the skin disease external prescription of specially a kind of antibacterial anti-inflammatory containing camellia oil and Preparation method.
Background technology
Skin disease is the common a kind of disease of the mankind, for example, nettle rash, eczema and newborn's eczema etc skin disease compared with To be common, this kind of disease is caused by bacterium infection, is mainly in the positions such as hand, foot, body, stock, treats the primary measure of above-mentioned disease It is antibacterium, antiseptic can be roughly divided into inorganic antiseptic class, organic antibacterial agent class, natural antibacterial agent class and natural biological antibacterial Agent class.Inorganic antiseptic class includes silver, copper, zinc, mercury, cadmium, lead, zinc oxide, copper oxide, ammonium dihydrogen phosphate, lithium carbonate etc., with Novel photocatalysis type and the nano composite anti-biotic material for carrying silver are Main Trends of The Development.Organic antibacterial agent class principal item has perfume (or spice) Oxalaldehyde or ethyl vanillin aldehydes compound, also including anilid class, imidazoles, thiazoles, isothiazolone derivative, quaternary ammonium Salt, double croak classes, phenols etc. are opened up using developing specially effect in the antiseptic of biomolecule such as microbial metabolism enzyme, membrane receptor etc. as it Open up direction.Natural antibacterial agent class essentially from natural plants extraction, including chitin, mustard, castor oil, horseradish etc..Naturally Biological antibiosis agent can derive from all organisms, mainly including polysaccharide, polypeptide and glycopeptide polymer-like substances.Although present market Upper dermopathic drug is more, but its therapeutic effect is poor, after smearing, therapeutic effect slowly effect, it is impossible to effectively control Treat skin disease.
Invention content
The purpose of the present invention is to provide the skin disease external prescription and preparation method of a kind of antibacterial anti-inflammatory containing camellia oil, To solve the problems mentioned in the above background technology.
To achieve the above object, the present invention provides following technical solution：
A kind of skin disease external prescription of the antibacterial anti-inflammatory containing camellia oil, is made of the parts by weight of following feed components： 300-310 parts of camellia oil, 130-140 parts of Asian puccoon, 200-230 parts of the coptis, 240-280 parts of Radix Isatidis, connects 230-250 parts of rheum officinale Stick up 340-350 parts, 250-290 parts of honeysuckle, 190-260 parts of Herba Andrographitis, 320-360 parts of Radix Glycyrrhizae, 305-310 parts of dandelion, 15-20 parts of purslane, 410-440 parts of cordate houttuynia, 200-230 parts of calculus bovis factitius, 250-300 parts of aspirin, wild chrysanthemum 200- 250 parts, 90-140 parts of mulberry leaf, 100-150 parts of adhesive, 50-70 parts of sodium chloride, 210-230 parts of honey, 50-60 parts of borneol and 90-110 parts of frutus cnidii.
A kind of skin disease external application preparation method of antibacterial anti-inflammatory containing camellia oil, includes the following steps：
S1. batch mixing：Camellia oil, rheum officinale, Asian puccoon, the coptis, Radix Isatidis, Fructus Forsythiae, honeysuckle, Herba Andrographitis, Radix Glycyrrhizae, chrysanthemum Fourth, purslane, cordate houttuynia, calculus bovis factitius, aspirin, wild chrysanthemum, mulberry leaf, sodium chloride, honey, borneol and frutus cnidii add together Enter into blender mixing, 100 revs/min of rotating speed, timing 20 minutes obtains mixture A；
S2. B liquid is made：The mixture A in S1 is taken out, is put into the pressure cooker after sterilizing, adds in distilled water, with submergence Subject to mixture A, set temperature is 97-100 DEG C, after boiling 30 minutes, obtains B liquid；
S3. it filters：Filter residue in the B liquid obtained in S2 is filtered to remove, obtains liquor C；
S4. D lotions are made：The liquor C obtained in S3 and adhesive are poured into earthen ware jars together, set turning for blender Speed is 100 revolutions per seconds, and after stirring 15 minutes, taking-up is placed in glass container, is added emulsifier, is made its emulsification, and D cream is made Body, as skin disease external plaster of the invention.
Preferably, the acid value of the camellia oil is less than 0.08mgKOH/g, peroxide value is less than 0.4mmol/kg.
Compared with prior art, the beneficial effects of the invention are as follows：The formula and processing technology that the present invention uses are simple, pass through Control working process parameter layer by layer, the drug produced can reach good antibacterial anti-inflammatory and treat dermopathic effect, right After dermal application, since the camellia oil in formula contains tea polyphenols and the important chemical substance of squalene, tea polyphenols can be effective The effect of sterilization and anti-inflammatory is played, meanwhile, using the anti-oxidation characteristics of squalene, squalene can treat nettle rash, eczema phase The skin disease of pass has prominent substantive distinguishing features, when people's skin bacterium infection occurs and causes skin disease, uses the present invention Drug can play bactericidal antiphlogistic in a short time, treat dermopathic advantageous effect.
Specific embodiment
Below in conjunction with the embodiment of the present invention, the technical solution in the embodiment of the present invention is clearly and completely described, Obviously, described embodiment is only part of the embodiment of the present invention, instead of all the embodiments.Based in the present invention Embodiment, those of ordinary skill in the art's all other embodiments obtained without making creative work, all Belong to the scope of protection of the invention.
Below in 3 kinds of embodiments, the acid value of the camellia oil of selection is respectively less than 0.08mgKOH/g, peroxide value is less than 0.4mmol/kg。
Embodiment 1
A kind of skin disease external prescription of the antibacterial anti-inflammatory containing camellia oil, is made of the parts by weight of following feed components： 300 parts of camellia oil, 230 parts of rheum officinale, 130 parts of Asian puccoon, 200 parts of the coptis, 240 parts of Radix Isatidis, 340 parts of Fructus Forsythiae, 250 parts of honeysuckle, 190 parts of Herba Andrographitis, 320 parts of Radix Glycyrrhizae, 305 parts of dandelion, 15 parts of purslane, 410 parts of cordate houttuynia, 200 parts of calculus bovis factitius, A Si 250 parts of woods, 200 parts of wild chrysanthemum, 90 parts of mulberry leaf, 100 parts of adhesive, 50 parts of sodium chloride, 210 parts of honey, 50 parts of borneol and snake 90 parts of machine tool.
A kind of skin disease external application preparation method of antibacterial anti-inflammatory containing camellia oil, includes the following steps：
S1. batch mixing：Camellia oil, rheum officinale, Asian puccoon, the coptis, Radix Isatidis, Fructus Forsythiae, honeysuckle, Herba Andrographitis, Radix Glycyrrhizae, chrysanthemum Fourth, purslane, cordate houttuynia, calculus bovis factitius, aspirin, wild chrysanthemum, mulberry leaf, sodium chloride, honey, borneol and frutus cnidii add together Enter into blender mixing, 100 revs/min of rotating speed, timing 20 minutes obtains mixture A；
S2. B liquid is made：The mixture A in S1 is taken out, is put into the pressure cooker after sterilizing, adds in distilled water, with submergence Subject to mixture A, set temperature is 97 DEG C, after boiling 30 minutes, obtains B liquid；
S3. it filters：Filter residue in the B liquid obtained in S2 is filtered to remove, obtains liquor C；
S4. D lotions are made：The liquor C obtained in S3 and adhesive are poured into earthen ware jars together, set turning for blender Speed is 100 revolutions per seconds, and after stirring 15 minutes, taking-up is placed in glass container, is added emulsifier, is made its emulsification, and D cream is made Body, as skin disease external plaster of the invention.
Embodiment 2
A kind of skin disease external prescription of the antibacterial anti-inflammatory containing camellia oil, is made of the parts by weight of following feed components： 305 parts of camellia oil, 240 parts of rheum officinale, 135 parts of Asian puccoon, 220 parts of the coptis, 260 parts of Radix Isatidis, 345 parts of Fructus Forsythiae, 270 parts of honeysuckle, 200 parts of Herba Andrographitis, 340 parts of Radix Glycyrrhizae, 307 parts of dandelion, 18 parts of purslane, 425 parts of cordate houttuynia, 220 parts of calculus bovis factitius, A Si 270 parts of woods, 230 parts of wild chrysanthemum, 120 parts of mulberry leaf, 125 parts of adhesive, 60 parts of sodium chloride, 220 parts of honey, 55 parts of borneol and snake 100 parts of machine tool.
A kind of skin disease external application preparation method of antibacterial anti-inflammatory containing camellia oil, includes the following steps：
S1. batch mixing：Camellia oil, rheum officinale, Asian puccoon, the coptis, Radix Isatidis, Fructus Forsythiae, honeysuckle, Herba Andrographitis, Radix Glycyrrhizae, chrysanthemum Fourth, purslane, cordate houttuynia, calculus bovis factitius, aspirin, wild chrysanthemum, mulberry leaf, sodium chloride, honey, borneol and frutus cnidii add together Enter into blender mixing, 100 revs/min of rotating speed, timing 20 minutes obtains mixture A；
S2. B liquid is made：The mixture A in S1 is taken out, is put into the pressure cooker after sterilizing, adds in distilled water, with submergence Subject to mixture A, set temperature is 100 DEG C, after boiling 30 minutes, obtains B liquid；
S3. it filters：Filter residue in the B liquid obtained in S2 is filtered to remove, obtains liquor C；
S4. D lotions are made：The liquor C obtained in S3 and adhesive are poured into earthen ware jars together, set turning for blender Speed is 100 revolutions per seconds, and after stirring 15 minutes, taking-up is placed in glass container, is added emulsifier, is made its emulsification, and D cream is made Body, as skin disease external plaster of the invention.
Embodiment 3
A kind of skin disease external prescription of the antibacterial anti-inflammatory containing camellia oil, is made of the parts by weight of following feed components： 300-310 parts of camellia oil, 250 parts of rheum officinale, 140 parts of Asian puccoon, 230 parts of the coptis, 280 parts of Radix Isatidis, 350 parts of Fructus Forsythiae, honeysuckle 290 Part, 260 parts of Herba Andrographitis, 360 parts of Radix Glycyrrhizae, 310 parts of dandelion, 20 parts of purslane, 440 parts of cordate houttuynia, 230 parts of calculus bovis factitius, 300 parts of aspirin, 250 parts of wild chrysanthemum, 140 parts of mulberry leaf, 150 parts of adhesive, 70 parts of sodium chloride, 230 parts of honey, 60 parts of borneol With 110 parts of frutus cnidii.
A kind of skin disease external application preparation method of antibacterial anti-inflammatory containing camellia oil, includes the following steps：
S1. batch mixing：Camellia oil, rheum officinale, Asian puccoon, the coptis, Radix Isatidis, Fructus Forsythiae, honeysuckle, Herba Andrographitis, Radix Glycyrrhizae, chrysanthemum Fourth, purslane, cordate houttuynia, calculus bovis factitius, aspirin, wild chrysanthemum, mulberry leaf, sodium chloride, honey, borneol and frutus cnidii add together Enter into blender mixing, 100 revs/min of rotating speed, timing 20 minutes obtains mixture A；
S2. B liquid is made：The mixture A in S1 is taken out, is put into the pressure cooker after sterilizing, adds in distilled water, with submergence Subject to mixture A, set temperature is 100 DEG C, after boiling 30 minutes, obtains B liquid；
S3. it filters：Filter residue in the B liquid obtained in S2 is filtered to remove, obtains liquor C；
S4. D lotions are made：The liquor C obtained in S3 and adhesive are poured into earthen ware jars together, set turning for blender Speed is 100 revolutions per seconds, and after stirring 15 minutes, taking-up is placed in glass container, is added emulsifier, is made its emulsification, and D cream is made Body, as skin disease external plaster of the invention.
Camellia oil in invention formula is full of nutrition, fatty acids (unrighted acid 93%, wherein oleic acid 82%, Linoleic acid 11%), camellianin, tea polyphenols, saponin, tannin and rich in antioxidant and with anti-inflammatory effect squalene, In, tea polyphenols are also known as tea tan, specific to act on：Anti-aging, radioresistance, the inhibition to cancer cell, antibacterial, sterilization, to AIDS The inhibiting effect of virus acts on the anti-solution of heavy metallic salt and biological alkalosis；It protects tooth improving eyesight and removes the effect of halitosis；It helps and disappears Change acts on；Enhance capilary obdurability, reducing blood lipid, prevent liver and coronary atherosclerosis.
Tannin has stronger reproducibility, can remove the superoxide radical in organism, slows down aging.There are anti-inflammatory, expelling parasite, drop The effects that blood pressure.Improve oxygen content of blood, improve due to chronic fatigue, work and study pressure is big, regular muscle power overdraw, air-conditioning Apathetic, memory loss caused by lacking oxygen in environment, the symptoms such as body is tired, the courage reduced in blood fat and blood are consolidated Alcohol, enhances body immunity, and preventing cold, prevention hepatitis and hepatic sclerosis lesion improve asthma, chronic cough and easy allergy Shape promotes human metabolism, accelerates body tissue reparation.
Importantly, squalene helps to maintain the softness health of skin.It is a kind of antioxidant, can be effectively improved Skin colour alleviates the relevant dermatopathy such as psoriasis and dermatitis, there is magical curative effect to human immune system.
Traditional antidermatosis drug and antidermatosis drug of the present invention, the comparison table of effect are as follows：
It is shown by Statistical Comparison, for the more traditional antidermatosis drug of antidermatosis drug in the present invention, the present invention Antidermatosis drug it is more preferable to treating skin disease effect.
After parts by weight of raw materials provided by the invention is prepared according to embodiment 1, embodiment 2 or embodiment 3, Dermatological Agents are fought The production of object, wherein, according to the parts by weight of its constitutive material each component in embodiment 2, the antidermatosis drug being modulated into, Good effect, will not also waste of materials, mixed economy and drug effect various aspects factor consider that selection example 2 is best.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with Understanding without departing from the principles and spirit of the present invention can carry out these embodiments a variety of variations, modification, replace And modification, the scope of the present invention is defined by the appended.

Claims (3)

1. a kind of skin disease external prescription of the antibacterial anti-inflammatory containing camellia oil, which is characterized in that by the weight of following feed components Measure part composition：300-310 parts of camellia oil, 230-250 parts of rheum officinale, 130-140 parts of Asian puccoon, 200-230 parts of the coptis, Radix Isatidis 240- 280 parts, 340-350 parts of Fructus Forsythiae, 250-290 parts of honeysuckle, 190-260 parts of Herba Andrographitis, 320-360 parts of Radix Glycyrrhizae, dandelion 305-310 parts, 15-20 parts of purslane, 410-440 parts of cordate houttuynia, 200-230 parts of calculus bovis factitius, 250-300 parts of aspirin, 200-250 parts of wild chrysanthemum, 90-140 parts of mulberry leaf, 100-150 parts of adhesive, 50-70 parts of sodium chloride, 210-230 parts of honey, borneol 50-60 parts and 90-110 parts of frutus cnidii.
2. a kind of skin disease external application preparation method of the antibacterial anti-inflammatory containing camellia oil as described in claim 1, it is characterised in that：Packet Include following steps：
S1. batch mixing：Camellia oil, rheum officinale, Asian puccoon, the coptis, Radix Isatidis, Fructus Forsythiae, honeysuckle, Herba Andrographitis, Radix Glycyrrhizae, dandelion, horse Bitterroot, cordate houttuynia, calculus bovis factitius, aspirin, wild chrysanthemum, mulberry leaf, sodium chloride, honey, borneol and frutus cnidii are added to together Mixing in blender, 100 revs/min of rotating speed, timing 20 minutes obtain mixture A；
S2. B liquid is made：The mixture A in S1 is taken out, is put into the pressure cooker after sterilizing, adds in distilled water, to submerge mixing Subject to object A, set temperature is 97-100 DEG C, after boiling 30 minutes, obtains B liquid；
S3. it filters：Filter residue in the B liquid obtained in S2 is filtered to remove, obtains liquor C；
S4. D lotions are made：The liquor C obtained in S3 and adhesive are poured into earthen ware jars together, set the rotating speed of blender as 100 revolutions per seconds, after stirring 15 minutes, taking-up is placed in glass container, is added emulsifier, is made its emulsification, D lotions is made, i.e., Skin disease external plaster for the present invention.
3. the skin disease external prescription of the antibacterial anti-inflammatory according to claim 1 containing camellia oil, it is characterised in that：The mountain The acid value of tea oil is less than 0.08mgKOH/g, peroxide value is less than 0.4mmol/kg.
CN201611241352.1A 2016-12-29 2016-12-29 The skin disease external prescription and preparation method of a kind of antibacterial anti-inflammatory containing camellia oil Pending CN108261473A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102114216A (en) * 2010-12-03 2011-07-06 郑延明 Externally applied antibacterial and antiphlogistic medicament and preparation method thereof
CN102861217A (en) * 2012-09-25 2013-01-09 黄盛焕 External emplastrum for treating malignant boil, sores and carbuncles
CN105267396A (en) * 2015-11-25 2016-01-27 严瑾 Antibacterial anti-inflammatory composition as well as preparation method and pharmaceutical preparation thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102114216A (en) * 2010-12-03 2011-07-06 郑延明 Externally applied antibacterial and antiphlogistic medicament and preparation method thereof
CN102861217A (en) * 2012-09-25 2013-01-09 黄盛焕 External emplastrum for treating malignant boil, sores and carbuncles
CN105267396A (en) * 2015-11-25 2016-01-27 严瑾 Antibacterial anti-inflammatory composition as well as preparation method and pharmaceutical preparation thereof

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Application publication date: 20180710