CN101428135A - Micro-element reinforced externally used liniment - Google Patents

Abstract

The invention discloses an externally applied embrocation for strengthening trace elements, in particular to an externally applied alcohol solution preparation which is prepared by fully utilizing natural animal and plant medicines in the natural world and snakes, bees, frogs and traditional Chinese medicine secret recipes which are rich in abundant and full trace elements, taking strengthened zinc, copper, iron, selenium, manganese, and the like as trace element strengthening agents and taking the traditional Chinese medicine proved recipes and the secret recipes as main factors, thereby changing the past externally applied embrocation which is prepared by chemicals, Chinese herbal medicines and hormones. The preparation uses the theory of element balance and health care medicine and seizes the trace elements with the immune function which is closely related to skin health to overcome and treat a variety of clinical skin disease and even refractory skin diseases. For example, the zinc and the iron participate in the regulation of human immune function, and the supplement of the zinc can increase T cells and improve the immunity. The supplement of the selenium can not only enhance the humoral immunity and significantly improve the antibody level, but also have the anti-cancer effect. The adequate amount of the manganese is the condition for generating normal antibodies. The copper has close relationship with connective tissue metabolism, melanin formation, blood making function and skin keratosis. The externally applied embrocation of the trace elements have sufficient amount of a variety of trace elements, and the skin can continuously absorb the trace elements by penetration by regular embrocation, thereby scientifically regulating, supplementing and agonizing the element balance in vivo and further preventing and treating a variety of skin diseases.

Description

A kind of micro-element reinforced externally used liniment

Technical field:

The present invention relates to a kind of micro-element reinforced externally used liniment, belong to element balance medical science and come the dermopathic brand-new technical field of prophylactic treatment, is external skin medicine application category.

Background technology:

Topical agent generally has oil solution, alcoholic solution and emulsion preparation, is used for being coated with and puts skin on the skin, treats various dermopathic a kind of topical agents, generally prepares with the medicine of chemical classes, Chinese herbal medicine, hormones in the past.Cause some dermatosiss to become to be difficult to clinically the persistent ailment of curing.

The present invention is a theoretical foundation with the element balance sanipratics, innovate with novelty, practical is the basis, with high neoplasm purification technique of modern times is practice, with zinc in the human body skin, copper, ferrum, manganese, various trace elements such as selenium lack and the not enough various skin disease that causes, even difficult dermatosis is true, with the natural Serpentis of nature, honeybee, the frog, primitive organism attitude in the Chinese medicine, human body easily absorbs, the absorbance height, nutrient substance is many and full macro micro element replenishes, regulate, the antagonist interior element is not enough or excessive, thereby reaches prevention and treatment various skin disease, even difficult dermopathic scientific and technical innovation and trial.

Enter the total amount of the various elements of human body, mainly be in gastrointestinal tract, to absorb by pickuping food, next is that injection absorbs, secondly be lung absorption again by respiratory system, be only osmotic absorption at last through skin, human body skin is the largest organ that contacts with the external world, also is the largest organ that absorbs and drain various elements.Itself also is made up of various atoms of elements, many dermatosiss are with regard to the quantity not sufficient that contains of elements such as zinc, copper, ferrum, manganese, selenium in the skin, lack or excessive causing, the constituent content of skin own is just very abundant to have kind more than 40 approximately according to the science test, especially zinc element just accounts for 20% of whole human body zinc content, therefore treat dermatosis with replenish, adjusting, antagonist interior element not enough or excessive, fundamentally work hard from this and just can accomplish that when the water comes, a channel is formed, the effect uniqueness.For example acne of youth is the dermatosis of a kind of adolescence of common pilosity, it mainly is adolescence zinc element deficiency, and cause androgen to increase, causing sebum secretion increases, cause follicular keratosis, cause the sebum acatharsia and cause acne, the a large amount of breedings of propionibacterium are inflamed, abscess etc., example can suppress the acne inflammation with the zinc preparation treatment, can oral zinc gluconate sheet 150mg every day, effective percentage can reach 86% after 6 weeks treatment, if every day the oral capsule of licorsinc that at every turn advances medicine .25-0.59 for three times, treat that effective percentage can reach 97.3% after 10 days, use that effective percentage reaches 100% after 5-7 days if be made into 0.5% mastic with the bile of Agkistrodon halys or Agkistrodon and vanishing cream, cure rate reaches 85%, trace it to its cause is to be rich in abundant zinc in the Fel Serpentis of Agkistrodon halys or Agkistrodon, copper, ferrum, manganese, elements such as selenium, belong to natural biological attitude organic element, human body easily absorbs, the absorbance height, therefore the fast and good effect of therapeutic effect, because human body is subjected to the influence of the factors such as chemical compound of the chemical form of element and composition again to the height of required trace element yield, thyroid patient and for example, because of iodine deficiency, Thallus Laminariae (Thallus Eckloniae) with the natural formation of occurring in nature enriches the iodine, it is safer to enrich the iodine than iodized salt, absorbance is higher, and and for example zinc deficiency is eaten the food of zinc supplement, dried Concha Ostreae, Cipangopaludina chinensis, it is good that the Stichopus japonicus geometric ratio is eaten the fortified zinc egg, it is better than eating the gluconic acid zinc metal sheet again to eat the fortified zinc egg, replenishes with the trace element in the nature animals and plants in a word, regulate, antagonist interior element counterbalance effect is better.

In the various trace element with the skin relation the closest be zinc, copper, ferrum, manganese and selenium etc., because of zinc deficiency appetite, digestion, Aging and obstacle immunocompromised, collagen is synthetic totally unfavorable when influencing nucleic acid and protein synthesis to fibroblastic hypertrophy and epithelial cell formation, and wound healing is slow.Copper and zinc mutually antagonism, when copper lacks, cutin forms bad, epiderm skin parakeratosis can occur, and hair waving, alopecia.Ferrum mainly participates in the synthetic of hemoglobin, and iron deficiency can cause first shape spoon and onychorrhexis, and selenium can influence the keratinization of epidermis program, reduces coming off of horn cell, has enhancing human body immunity power, and anticancer and opposing noxious substance is to the multiple effects such as injury of health.

Summary of the invention:

The present invention makes full use of that nature natural animals and plants Serpentis, honeybee, the frog, Chinese medicine are effectively filled a prescription, many and full macro micro element in the secret recipe, nutrient substances such as multivitamin, through the biological manufacturing technology of modern pin high-tech, the micro-element reinforced externally used liniment of making, be used for common multiple dermatosis or even some skin stubborn diseases, being controlled effectively and peculiar effect, is trace element new invention and practice on treating skin disease.

Below in conjunction with embodiment the present invention is further set forth.

Micro-element reinforced externally used liniment, following list of references

1, Yan Shiming etc., practical element medicine, publishing house of Henan Medical Univ., 1999.1

2, clock dawn, old man etc. write element balance sanipratics, Guangdong Economic publishing house, 2003.6

3, Song Zhaoyou chief editor, dermatosis Chinese medicine for external application, People's Health Publisher, 2002.3

4, one, two dermatological agent sections of attached institute of Xi'an Medical University, dermatosis recipe drug handbook, the Shaanxi People's Press, 1977.9

5, Ge Fengchen chief editor, the magical effect of bee product odd-prescription, Jilin technology publishing house, 2002.6

6, Yang Pengju chief editor, the single medicine special effect of the traditional Chinese medical science is handed down in a direct line from the master Xueyuan Press, 2006.2

7, Lv Wenying, the clinical trace element of acne is learned, and 1994.5,266-270

8, Wang Liping, acne mixture treatment acne curative effect is inquired into trace element and health research, 1998.15,2:46

9, Zhang Yonghuai writes, trace element and clinical, Chinese Medicine science and technology publishing house, 1997.8

Embodiment (1)

Manganese chloride 0.5g

Oxide powder and zinc 5g

Propolis powder 2g

Cortex Pseudolaricis 20g

Cortex Phellodendri 5g

Fructus Cnidii 5g

Salicylic acid 8g

Benzoic acid 6g

Camphora 1g

15% Serpentis tissue extract 10ml

The 10%th, Chinese toad extracting solution 10ml

75% ethanol adds to 100%

Method for making: get Cortex Pseudolaricis, Cortex Phellodendri breaks into powder, press osmosis with Fructus Cnidii, after 75% alcohol-pickled 3-5 days, at last salicylic acid, benzoic acid, Camphora are added to adding oxidation zinc powder, propolis powder, Serpentis tissue and Bufo siccus extracting solution after full dose is got penetrating fluid that to stir well filtration standby from adding ethanol on the filter in infiltration, be applicable to hands, foot, body, tinea cruris, skin ulceration, skin ulcer rash.Effect: antiinflammatory, parasite killing, antipruritic, skin care.

Embodiment (2)

10% Chinese toad extracting solution 10ml

Thymol 0.5g

10% Periostracum Serpentis extracting solution 10ml

Propolis powder 20g

Salicylic acid 0.05g

Mentholum 1g

Carbolic acid 1g

Diphhydramine hydrochloride 0.25g

Sodium thiosulfate 4g

Gibberellins 0.03g

Glycerol 50ml

Zinc sulfate 0.2mg

Copper sulfate 0.03mg

75% ethanol is added to 100ml

Method for making: get thymol, Mentholum, carbolic acid, salicylic acid, propolis powder, gibberellins, diphhydramine hydrochloride, zinc sulfate, copper sulfate and be dipped in 75% the alcoholic solution, add propolis powder and add 10% Periostracum Serpentis and 10% Chinese toad extracting solution again, other get sodium thiosulfate adding distil water dissolving back stir mix after at once.

Annotate: (1) gibberellins is utmost point unease at normal temperatures

(2) sodium thiosulfate easily folds sulfur so prepare with the fresh aquae destillata that boils when preparation in aqueous solution, can add 0.02% sodium carbonate or 0.7% sodium bicarbonate and fold with alleviation about 8-9.5 as tranquilizer or with sodium carbonate levelling pH value.

Effect: be suitable for acute dermatitis, eczema, ooze out the phase and phase dermatitis is oozed out in other erosions.

Embodiment (3)

Cortex Pseudolaricis 62g Radix Sophorae Flavescentis 310g oxide powder and zinc 500g

50 hardships of Semen Euphorbiae root bark 150g Agkistrodon halys dry powder 500g

(grinding to the powder)

Radix Sangusorbae 150g Cortex cercis chinensis 310g propolis powder 300g

30 Camphora 310g of Chinese blister beetle of class 100g (cloth bag) Scolopendra

Bufo siccus dry powder 10g manganese oxide 15g

Method for making: medicine-feeding immerses so that ultra-fine grinding processing back is common that sealing 2 all after-filtration go liquid to deposit wine among the 75% alcoholic solution 5000ml, and camphorating to dissolve is mixed again, after add following medicine again.

Salicylic acid 6% benzoic acid 12%

The inferior maple 1% of Lin Ermin 0.5% diformazan

Medicine-feeding mixes stirring back ethanol liquid and adds to 100%

Effect: we have killing parasites for relieving itching, are applicable to psoriasis, brothers' tinea corporis and cruris, neurodermatitis.

Embodiment 4

Radix et Rhizoma Rhei (processed) 100g Cortex Phellodendri 20g Borneolum Syntheticum 20g

Mentholum 40g thymol 20g chlorphenamine 5g

Phenol 20g diformazan trident maple 20g propolis powder 25g

10% Periostracum Serpentis tissue extract 50g ferrous gluconate 1g selenium yeast powder 0.5g

Oxide powder and zinc 5g

Method for making: Radix et Rhizoma Rhei (processed), Cortex Phellodendri is ground into fine powder, added for 95% an alcohol-pickled week after, being put in poison to stir into to add after the emulsus adds 95% ethanol 500ml after Periostracum Serpentis organizes the extract restir evenly again, be about 60 ℃ with distilled water diluting to alcohol concentration then, it is standby promptly to bottle.

Effect: be mainly used in dermatitis, eczema, miliaria, itching skin disease etc.

Embodiment 5

Thymol 0.5g salicylic acid 0.5g

Mentholum 1g carbolic acid 1g

Diphhydramine hydrochloride 0.25g sodium thiosulfate 4g

Gibberellins powder 0.03g glycerol 50ml

Propolis 20g 50% ethanol 80ml

Oxide powder and zinc 15g distilled water 20ml

Method for making: getting medicine-feeding and being dissolved in glycerol adding in the ethanol, other gets distilled water and adds sodium thiosulfate to solution to mix stirring then promptly good.

Effect: be used for acute dermatitis (no erosion is oozed out)

Embodiment 6

Pseudobulbus Bletillae (Rhizoma Bletillae) 500g Fel Serpentis powder 5g propolis powder 30g

Radix Stemonae 500g Cortex Pseudolaricis 500g Semen Arecae 500g

Chinese blister beetle of class (remove wing, remove foot) 100g Fructus Zanthoxyli 500g Semen Hydnocarpi core 250g

It is cataclasm respectively and roll to add medicine to, put (fine powder is at last, coarse powder infra) in the percolation filter, in addition the Chinese blister beetle of class porphyrize is mixed with Semen Hydnocarpi core and smash into the mud shape, put the percolation filter the superiors, on add special wooden orifice plate and add 60-75% ethanol then and exceed to add a cover behind about 10 centimeters of the powder and soak 5-7 day, suitably loosen two gauge taps, make the ethanol amount of output and the diafiltration juice raw material balance total amount of output, use ethanol 15000ml, last filtrate adds 5% salicylic acid in proportion, and 10% benzoic acid stirs promptly.

Effect: cure mainly psoriasis, neurodermatitis, tinea manus and pedis.

Embodiment 7

Venenum Bufonis, each 10g Herba Asari 35g Radix Aconiti 50g of Flos Mume

Zaocys 80g Radix Angelicae Sinensis, each 50g Camphora 40g of dried meat floss

3 of Scorpio 6g Rhizoma Zingiberis, each 75g Scolopendras of Flos Carthami

95% ethanol 2500ml propolis powder 20g

Oxide powder and zinc 30g

It is standby that 1 all backs are soaked in medicine-feeding

Effect: cure mainly the not broken person of chilblain

Embodiment 8

Radix Isatidis 50g Radix Sophorae Tonkinensis 50g Herba Equiseti Hiemalis 50g

Rhizoma Cyperi (vinegar stir-fry) 50g Semen Coicis (stir-fry) 50g Periostracum Serpentis powder 5g

Concha Ostreae 25g Fel Serpentis dry powder 3g

Annotate: the every 100g of Concha Ostreae contains 121mg zinc element, ferrum 7.1mg, manganese 0.85mg, copper 8.13mg, selenium 86.64mg.

Method for making: get Concha Ostreae and add and add all the other 5 flavors when water 500ml fries in shallow oil about 400ml water again and fry in shallow oil soup and be condensed into the minimum 100ml of being not less than of 200ml and dip in medicine and embrocate treatment, disease damage surface is come off, once a day.

Effect: cure mainly heat-clearing and toxic substances removing, to verruca vulgaris, verruca plana has unique effect.

Embodiment 9

Fructus Psoraleae 30g Radix Angelicae Dahuricae 20g Radix Arnebiae (Radix Lithospermi) 15g

Dexamethasone 20mg quench pain medicated powder 250mg 15% Serpentis tissue extract 50ml

The inferior maple 40ml of the big toad 30ml dimethyl of 10% China oxide powder and zinc 20g

The bufonid toad ethanol extract

Method for making: first three flavor is put into the ethanol sealing soaked 7 days, filter surplus about 60ml of medicinal liquid and dexamethasone, indometacin mixes molten sparing and shakes all standby into the inferior maple of dimethyl.

Effect: cure mainly vitiligo

Embodiment 10

(1) thin collection, Radix Aconiti Kusnezoffii, each 5g of Semen Strychni, propolis powder 10g, dense lysol liquid 100ml can use above drug immersion in 10-15 days in dense lysol liquid, and the time spent puts the aseptic cotton dip in liquid medicine embrocates the skin lesion place, is sure not to embrocate on normal skin.With neurodermatitis 230 examples of we's treatment, 226 examples of fully recovering, invalid 4 examples, total effective rate 98.26%.

(2) Chinese blister beetle of class 8g, Realgar, copper cash, each 12g of Borneolum Syntheticum, Radix Sophorae Flavescentis 60g

75% ethanol is soaked in medicine-feeding, outer putting on the skin behind the 1000ml first quarter moon

Treatment neurodermatitis 82 examples, 51 examples of fully recovering, total effective rate is 96% effect: cure mainly neurodermatitis.

Claims (8)

1, a kind of external liniment of reinforced micro-element is characterized in that containing in the contained external liniment percentage by weight (parts such as trace element and Serpentis, honeybee, the frog).

Oxide powder and zinc 0.5-30%

Selenium yeast powder 0.05-0.2%

Copper sulfate 0.05-0.5%

Ferrous gluconate 0.05-0.5%

Manganese chloride 0.05-10%

Propolis powder 0.5-35%

Bufo siccus powder 0.5-0.3%

Fel Agkistrodon halys dry powder 0.5-3%

Periostracum Serpentis powder 5-20%

Nidus Vespae dry powder 2-10%

Copper sulfate 0.03-0.5%

Zinc sulfate 0.03-0.5%

15% Serpentis tissue extract 5-30%

The 10% alcohol extract 5-30% of Bufo siccus office

2, according to claims 1, a kind of external liniment of reinforced micro-element is characterized in that contained weight and percentage ratio (Chinese medicine part):

Scholar's rose of Sharon skin 3-50% Cortex Phellodendri 2-6%

Fructus Cnidii 3-7% Radix Sophorae Flavescentis 3-6%

Radix Sangusorbae 2-5% Mylabris 0.5-4%

Semen Euphorbiae 0.5-2% Cortex cercis chinensis 3-7%

A bitter root bark 3-6% Radix et Rhizoma Rhei (processed) 15-25%

Scolopendra 0.5-5% Pseudobulbus Bletillae (Rhizoma Bletillae) 5-30%

Semen Arecae 5-30% Semen Hydnocarpi 5-20%

Radix Stemonae 1-5% Fructus Zanthoxyli 5-30%

XIZU 0.5-3% Flos Mume 0.5-5%

Radix Aconiti Kusnezoffii 2-5% Radix Angelicae Sinensis 0.5-5%

Radix Aconiti 2-5% Scorpio 0.05-0.5%

Cortex Cinnamomi 0.5-5% Flos Carthami 1-5%

Rhizoma Zingiberis 1-5% Radix Sophorae Tonkinensis 3-10%

Radix Isatidis 3-10% Rhizoma Cyperi 3-10%

Herba Equiseti Hiemalis 3-10% Concha Ostreae 3-10%

Semen Coicis 3-10% Radix Angelicae Dahuricae 5-20%

Fructus Psoraleae 5-30% Semen Strychni 2-5%

Radix Arnebiae (Radix Lithospermi) 3-15%

3, according to staying sharp claim 1,2, a kind of external liniment of reinforced micro-element is characterized in that its formulation weight precentagewise (Western medicine part):

The stupid formic acid 10-15% of salicylic acid 3-8%

Camphora 1-3% thymol 0.5-5%

Friend 0.1-0.5% is drawn in carbolic acid 1-3% hydrochloric acid benzene sea

Sodium thiosulfate 1-5% gibberellins 0.03-0.06%

Diformazan trident maple 0.5-3% chlorphenamine 0.3-1%

Indometacin 0.05-0.5% dexamethasone 0.03-0.5%

4, according to claims 1,2,3, a kind of external liniment of reinforced micro-element, it is characterized in that: its prescription form must possess Chinese medicine is arranged, Western medicine, microelement enhancer Serpentis, honeybee, the frog etc., cause rare live part more than 4 kinds or four kinds to form, indispensable.

5, according to claims 1,2,3,4, a kind of external liniment of reinforced micro-element is characterized in that its prescription is mentioned in forming

(1) Serpentis: refer to land Serpentis, desert Serpentis, all nontoxic or deleterious Serpentis classes of ocean Serpentis, and their skin, gallbladder, meat, oil, the tongue of Serpentis, viscera tissue extracting solution, and the dried powder made of each tissue etc.;

(2) honeybee: refer to domestic or wild Mel, Lac regis apis, Cera Flava, propolis, Nidus Vespae, Tinea Apis or adult, raw material or finished products such as bee pollen, honeybee product, made dried powder;

(3) frog: skin, Bufo siccus dry powder and the Bufo siccus tissue extract etc. that refer to Chinese toad.

6, according to claims 1,2,3,4,5, a kind of external liniment of reinforced micro-element is characterized in that: in preparation pharmaceutical formulation process, must take superfine, cryotherapy vacuum, modern supercritical fluid CO ²Abstraction technique etc.Avoid heating, especially high temperature is principle not destroy original medicine effective active components, fully keeps the trace element in the active drug, losses such as vitamin, aminoacid, protein, enzyme as far as possible.

7, according to claims 1,2,3,4,5,6, a kind of external liniment of reinforced micro-element, it is characterized in that: strengthen the trace element that adds, its composition source, in principle with the native element composition in the natural animal and plant medicine of nature, also can decide according to practical situation with reference to adding concrete amount in conjunction with the amount of element of required absorption people's every day of one 70 kg body weight;

(1) ferrum element: need take in 15ml normal every day, available ferrous acetate, ferrous sulfate, and iron dextran, ferrous gluconate is chosen any one kind of them;

(2) zinc: the normal person need take in 14.6ml every day, the interpolation of choosing any one kind of them in available zinc gluconate, zinc acetate, the zinc oxide;

(3) manganese: need normal person every day 4.4ml, the interpolation of choosing any one kind of them of available manganese chloride, manganese acetate;

(4) copper: need normal person every day 1.33ml, the interpolation of choosing any one kind of them of optional copper acetate, amiodarone, copper oxide, copper sulfate;

(5) selenium: the normal person needs 0.068mg, optional selenium yeast, sodium selenite, selenic ester polysaccharide ratio, the interpolation of choosing any one kind of them every day.

8, according to claims 1,2,3,4,5,6,7, a kind of external liniment of reinforced micro-element is characterized in that: the medicine material place of production is pure, and quality is fresh superior, the free from extraneous odour free from admixture, and no pathological changes, nothing is gone mouldy, aromatic flavor.