CN107714825A - A kind of coating film of sterilizing and itch-relieving - Google Patents

A kind of coating film of sterilizing and itch-relieving Download PDF

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Publication number
CN107714825A
CN107714825A CN201711335438.5A CN201711335438A CN107714825A CN 107714825 A CN107714825 A CN 107714825A CN 201711335438 A CN201711335438 A CN 201711335438A CN 107714825 A CN107714825 A CN 107714825A
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grams
selenium
coating film
zinc
gram
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李明山
李传志
李保山
程龙
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Fuyang City Balance Medical Health Apparatus Co Ltd
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Fuyang City Balance Medical Health Apparatus Co Ltd
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

The invention discloses a kind of coating film of sterilizing and itch-relieving, it is mainly prepared by the achene of Siberian cocklebur, dandelion, datura flower, the Radix Astragali, willow root by certain consumption proportion, medicine of the present invention has clearing heat and detoxicating, inducing diuresis for removing edema, scattered wind is antipruritic, and the function of clearing damp desinsection is quick for treating pruitus, good effect, do not pollute clothing.

Description

A kind of coating film of sterilizing and itch-relieving
Technical field
The present invention relates to a kind of antipruritic medicine, especially a kind of antipruritic coating film.
Background technology
Pruitus is a kind of common skin disease, and pars affecta skin is coarse, and respective regions show lichen sample lesion, scratch rear skin It is rubescent, itched when itching very with also not understanding of scratching of corn ear, it is oral, external application is calm and drug desensitization neither proves effective, influence to fall asleep, outer painting Clothes is also easily made in medication dirty, and patient is to suffer untold misery.
The content of the invention
It is an object of the invention to provide a kind of sterilizing and itch-relieving coating film, to solve the pain of patient, releases itch, prevents Pollution to clothing.
The solution of the present invention is from the achene of Siberian cocklebur, dandelion, datura flower, the Radix Astragali, Liu Gen, selenium, zinc, nystatin, Yi Qu Prepared by health azoles, gelatin, aminoglycoside, water soluble vitamin, each efficacy of drugs is produced these drug regimens Synergy, so as to effectively reach the effect of sterilizing and itch-relieving.Wherein it is that temperature is poisonous because its nature and flavor is sweet from the achene of Siberian cocklebur, Entering lung, Liver Channel, there is scattered wind, relieve pain, clearing damp, the function of desinsection controls anemofrigid headache, nasosinusitis, dentalgia, wind-cold-dampness arthralgia, four pin contractions pain, Scabies leprosy, itch.It is because its nature and flavor bitter sweet from dandelion, trembles with fear, enter liver, stomach, there is clearing heat and detoxicating, the function of diuresis dissipating bind, Control acute mastitis, adenolymphitis, scrofula, boil poisonous soreness, acute conjunctivitis, cold, fever, acute tonsillitis, acute branch gas Guan Yan, gastritis, hepatitis, cholecystitis, urinary tract infections.It is because its nature and flavor is pungent from datura flower, temperature is poisonous, enters lung channel, and there have to be fixed Asthma, wind-dispelling, the function of narcotic analgesic, controls asthma , Jing Epilepsy, arthralgia pain due to rheumatism, tinea pedis, sore pain, and make surgical operation anesthetic. It is the tepor because its nature and flavor is sweet from the Radix Astragali, enters lung, the spleen channel, it is raw to defend solid table, inducing diuresis for removing edema, eliminating toxic, the work(of myogenic with beneficial Can, control spontaneous perspiration, night sweat, blood-arthralgia, edema, ulcer do not burst or burst and hold back long；The function of using and have tonifying middle-Jiao and Qi is processed, controls internal injury overstrain, spleen Empty diarrhea, prolapse of the anus, deficiency of vital energy blood take off, and collapse band and the disease of all laboured breathing deficiency of blood.It is because its is bitter in taste from willow root, trembles with fear, favourable water, It is treating stranguria, wind-dispelling, the function of dehumidifying, gonorrhoea is controlled, gonorrhoea, oedema, jaundice, rheumatalgia pain, yellow water wet sore, is had a toothache, scald.From Selenium, selenium are the essential trace elements of the human bodys, are played in vital movement and resist disease, prevent aging, enhancing immunologic function, so as to Have the function that to balance body.Selenium deficiency can cause cardiovascular and cerebrovascular diseases, hypertension metabolism disease, enterogastric diseases, hepatopathy, asthma, cancer More than the 40 kinds of disease such as disease it is occurred frequently.FDA (Food and Drug Adminstration) in 2003（FDA）Formal medical statement selenium is cancer suppressing agent.Selenium Cancer-resisting effect has been written into the junior three《Chemistry》Textbook.The World Health Organization suggests：Human body supplements the selenium of 200 micrograms daily Can be with the occurred frequently of prevention of various diseases.Nutritional significance：1. selenium has antitumaous effect.Human body selenium deficiency is susceptible to suffer from liver cancer, lung cancer, stomach cancer, food Pipe cancer, kidney, prostate cancer, carcinoma of urinary bladder, cervical carcinoma, leukaemia etc..2. selenium Wheat Protein.Selenium is best anti-aging thing Matter, if human body has lacked selenium and " will be no longer young ", it can cause to become old and weak before one's age；3. selenium can strengthen body immunity.Selenium deficiency Decline the immunocompetence of human body.4. selenium plays the role of antagonism harmful heavy metal.Selenium deficiency easily triggers in the heavy metals such as lead, arsenic, cadmium Toxication shape.5. selenium can adjust the absorption and utilization of vitamin A, vitamin C, vitamin E, vitamin K.Selenium deficiency can trigger closely Depending on, cataract, retinopathy, fundus oculi disease, the disease such as age-related macular degeneration.6. selenium has the function of the synthesis of regulatory protein matter. Selenium deficiency can trigger protein energy shortage property malnutritive, chromosome damage etc..7. selenium can strengthen reproductive function.Selenium deficiency can draw Launch fertilization failure, low sperm activity, deformity occurs, conception rate reduces, hysteritis incidence of disease rise etc. symptom.Selenium element is The required composition of peroxidase in refining, when Se content lowers in seminal fluid, the activity reduction of this enzyme, it is impossible to suppress Spermatoblast membrane lipid peroxidation reacts, and causes Sperm lesion, and dead essence increases, and vigor declines.8. selenium is the important of the function of muscle Composition, selenium deficiency can make skeletal muscle atrophy and in canescence stripes, myocardial damage, the change of cardiac muscle cell's compactness occur, lipid increases It is more, calcium deposition, cause disease.The resident in high pollution area is particularly lived in, lives in the resident in poor selenium area, more Require supplementation with selenium.Because the organ of long-term storage selenium is not present in selenium in human body, the selenium needed for body should obtain constantly from diet To the selenium of sufficient amount, the balance of selenium concentration has important protective effect to the physiological function of many organs, tissue and promotes to make With.When selenium deficiency, human immunological competence's decline is just easily lead to, threatens human health and more than 40 kinds of disease of life Sick all relevant with human body selenium deficiency, such as cancer, cardiovascular disease, hepatopathy, cataract, pancreatic disease, diabetes, genital system diseases Symptom.For normal, everyone daily total requiremants, the daily food of Chinese adult more than the microgram of selenium-supply 25 has health care work outside With；It is more than the outer microgram of selenium-supply 50 of the daily food of selenium deficiency adult or 75 micrograms.Due to selenium deficiency in the soil of China 72%, natural In food, the cereal crops Se content such as wheat, rice, corn as staple food crop is below 40 μ g/kg, and compatriots are daily Selenium intake less than world health organisation recommendations 50 μ g minimum intake, day selenium intake there was only 30-45 μ g, less than day The countries such as sheet, Canada, the U.S..And selenium-rich rice, 100 micrograms（Selenium-rich corn powder）, pluck, fish, seafood, mushroom, Egg, garlic, ginkgo etc. are all higher containing selenium element, and the crowd of selenium deficiency can suitably increase the food of this respect.From zinc, zinc It is one of the essential trace elements of the human body, in the important physiology courses such as growth in humans's development, reproduction heredity, immune, endocrine Play an important role.The effect of zinc：Promote growing for human body, the children and adolescents in growth and development stage are such as Fruit lacks, and can cause depauperation.When lacking serious, it will cause " nanism " and intelligence development bad.Zinc is brain cell growth Key, zinc-deficiency can influence the function of brain, reduce brain cell.Human normal appetite is maintained, zinc-deficiency can cause the sense of taste to decline, go out Existing apocleisis, partial eclipse even different food.Strengthen body immunity, Zn-ef ficiency is the nutrient of immune organ thymus development, only zinc amount Thymus development can be just effectively ensured in abundance, normal differentiation T lymphocytes, promote cellular immune function.Promote wound and wound Healing, it is exactly to be used for treating skin disease that zinc supplementation agent is applied to clinical earliest.Influence metabolism and the normal vision of vitamin A, zinc Clinically show as it is beneficial to eyes, exactly because zinc play the role of promote vitamin A absorption.The absorption of vitamin A is not from Open zinc.Vitamin A is usually stored in liver, when human body needs, vitamin A is transported in blood, this process is to lean on Zinc completes " to mobilize " work.The normal spermatogenesis of male are maintained, Zn-ef ficiency is largely present in male testical, participates in essence The process of whole generation, maturation and the capacitation of son.Once male's zinc-deficiency, it may result in sperm quantity reduction, vigor declines, seminal fluid Liquefy bad, ultimately result in male sterility.Zinc-deficiency, which also results in teenager, not to be had secondary sex characters to occur, is unable to normal reproductive hair Educate.Regulation influences the various enzymes and acceptor of physiological brain function, and zinc plays very in the Physiological effect of various mammal brains Important effect, it is indispensable in a variety of enzymes and function of receptors regulation, the 26S Proteasome Structure and Function of nervous system is also affected, with Generation, the development of the spirit aspect obstacle such as obsession have certain contact.The biology conjunction of other zinc and DNA and RNA, protein Into closely related, when zinc deficiency in human body, various harmful effects may be caused, may cause emotional lability, it is suspicious, depressed, Emotional stability declines and cognitive impairment.From nystatin, nystatin（Nystatin）For polyene antifungal medicine.Tool is wide Compose antifungic action, nystatin is high to the antibacterial activity of Mycotoruloides, Cryptococcus neoformans, aspergillus, mucor, sporidiole bacteria, Histoplasma capsulatum, Blastomyces dermatitidis and dermatophyte are generally sensitive to this product.Intestines and stomach do not absorb after oral, to conventional mouth Blood concentration is extremely low after dosing, to Systemic fungal infections without therapeutic action.Local topical is not also by skin and mucosal absorption.Mainly For oral medication alimentary canal candida albicans enteritis, topical application treatment oral cavity monilial infection, skin and mucosa monilial infection, the moon Road candidiasis, and for preventing the fungoid suprainfection caused by long-term use of broad-spectrum antibiotic, also dripped available for vagina Insect infection.It is invalid to systemic fungal infection.From Itraconazole, Itraconazole（Itraconazole）For triazole type of new generation High-efficiency broad spectrum antifungal, can binding to fungal Cytochrome P450 isodynamic enzyme, suppress its ergosterol synthesis.This product is to skin tinea Bacterium, Mycotoruloides, neogenesis cryptococcus, Pityrosporum, Eurotium, Histoplasma, Paracoccidioides brasiliensis, Shen Ke The infection such as sporothrix, Fonsecaea, Cladosporium, Blastomyces dermatitidis are effective.It is mainly used in caused by deep fungal System infections, such as blastomycosis, histoplasmosis, paracoccidioidomycosis, chromoblastomycosis, sporotrichosis, coccidioides immitis Disease etc..It can also be used for candidiasis and aspergillosis.From gelatin, gelatin（Gelatin）It is by animal skin, bone, sarolemma, flesh evil spirit Turn into white or faint yellow, translucent, micro-strip gloss thin slice or powder Deng the collagenous portion degraded in connective tissue；Therefore again It is called animal gelatin, fat glue.Industrial gelatine is to be colourless to pale yellow transparent or thin slice or the powder such as translucent.It is tasteless, it is odorless. Water swelling in cold water.It is dissolved in hot water.Glycerine and acetic acid are dissolved in, insoluble in ethanol and ether.Gelatin belongs to a kind of macromolecular Hydrophilic colloid, it is a kind of higher low-calorie health food of nutritive value, can be used for making additive of candy, frozen food addition Agent etc..In addition, gelatin is also widely used in medicine and chemical industry.From aminoglycoside, aminoglycosides antibiotics （aminoglycosides）All it is combined into by the glucoside member of amino glycan molecule and non-saccharide part, it is big mould including streptomysin, celebrating Element, kanamycins, SISO and artificial semi-synthetic TOB, amikacin, Netilmicin etc..Common feature, such as Good water solubility, property are stable；In addition, in antimicrobial spectrum, antibacterial mechanisms, Binding rate of serum protein, gastrointestinal absorption, through renal excretion, and Adverse reaction etc. also has general character.Aerobic gram negative bacilli has powerful antibacterial activity, such as EHEC, klebsiella Category, Enterobacter, Proteus, Shigella, Serratia, Salmonella etc..To alcaligenes, Moraxella, Chinese holly Rafter acid Pseudomonas, pseudomonas aeruginosa, Brucella, hemophilus and Mycobacterium etc. also have certain antibacterial activity.Amino Effect of the glycoside to gram-negative coccis such as neisseria gonorrhoeae, Neisseria meningitidis is poor；To each group of streptococcus (such as A Group of streptococcus, Streptococcus viridans, streptococcus pneumonia) effect it is weak, enterococcus spp to most resistances, mycobacterium tuberculosis pair Streptomysin is more sensitive.From water soluble vitamin, water soluble vitamin（water-soluble vitamins）Being can be in water One group of vitamin of dissolving, it is often the part of coenzyme or prothetic group.Mainly include vitamin B1, vitamin B2 and vitamin C Deng.One kind can be dissolved in the organic nutrition molecule of water.Including the B family vitamin to be played an important role in the catalysis of enzyme and Ascorbic acid（Vitamin C）Deng.Water soluble vitamin is often the part of coenzyme or prothetic group.Mainly include vitamin B1, tie up Raw plain B2 and vitamin C etc..One kind can be dissolved in the organic nutrition molecule of water.Played an important role including in the catalysis of enzyme B family vitamin and ascorbic acid（Vitamin C）Deng.
Cang'erzi San wind relieves pain in prescription, and clearing damp desinsection is monarch drug in a prescription；Dandelion, datura flower have clearing heat and detoxicating, dispelling wind-evil and transforming calculus Function be ministerial drug, three taste medicines play clearing heat and detoxicating jointly, the function of dispelling wind-evil and transforming calculus, can effect a permanent cure；Radix Astragali inducing diuresis for removing edema, eliminating toxic life Flesh is adjutant；Willow root promoting diuresis for stranguria, dispelling wind and eliminating dampness is makes medicine, and all medicines are to take stopgap measures with being left.
Medicine of the present invention employs membranization generation compounded technology, and after decoction sprays, voluntarily conjunctiva is covered in affected part on top layer, on Layer can reduce the loss of decoction, prevent the pollution to clothing, and lower floor can promote the infiltration of decoction and the absorption of skin, go during dressing Except conveniently, patient is willing to accept.
Embodiment
The dosage of drug component of the present invention is also that inventor show that the dosage of each component is such as by largely groping to summarize Under：
50 grams of the achene of Siberian cocklebur, 10 grams of dandelion, 3 grams of datura flower, 15 grams of the Radix Astragali, 18 grams of willow root, 1 gram of selenium, 1 gram of zinc, nystatin 0.25 gram, 0.2 gram of Itraconazole, 15 grams of gelatin, 2 grams of aminoglycoside, 2 grams of water soluble vitamin.
The preparation method of the present invention is as follows：
The achene of Siberian cocklebur, dandelion, datura flower, the Radix Astragali, willow root are put into decocting container, add 1 liter of water, is soaked 2 hours, intense fire boils Boiling, use instead when being cooked by slow fire to 200ml decoctions, filter out the dregs of a decoction, multiply heat and add selenium, zinc, nystatin, Itraconazole, gelatin, ammonia Base glycoside, water soluble vitamin, which are mixed evenly, produces antipruritic liquid.
The beneficial effect of medicine of the present invention is expanded on further with reference to test example.
Test example：
Patient 25 is tested, in use, first embathing in affected part totally with hot water, affected part exfoliating is smeared with light-coloured vinegar after drying, then Cutin is washed away with warm water, after drying, then antipruritic liquid is sprayed into affected part, twice a day, is used continuously 10 days, the people of result of the test 20 fullys recover from an illness More, 4 people take a turn for the better, and 1 people is invalid, total effective rate 96%.

Claims (2)

  1. A kind of 1. coating film of sterilizing and itch-relieving, it is characterised in that：It is made up of the raw material of following dosage：
    50 grams of the achene of Siberian cocklebur, 10 grams of dandelion, 3 grams of datura flower, 15 grams of the Radix Astragali, 18 grams of willow root, 1 gram of selenium, 1 gram of zinc, nystatin 0.25 gram, 0.2 gram of Itraconazole, 15 grams of gelatin, 2 grams of aminoglycoside, 2 grams of water soluble vitamin.
  2. A kind of 2. preparation method of sterilizing and itch-relieving coating film, it is characterised in that：The preparation method of coating film is as follows：
    The achene of Siberian cocklebur, dandelion, datura flower, the Radix Astragali, willow root are put into decocting container, add 1 liter of water, is soaked 2 hours, intense fire boils Boiling, use instead when being cooked by slow fire to 200ml decoctions, filter out the dregs of a decoction, multiply heat and add selenium, zinc, nystatin, Itraconazole, gelatin, ammonia Base glycoside, water soluble vitamin, which are mixed evenly, produces antipruritic liquid.
CN201711335438.5A 2017-12-14 2017-12-14 A kind of coating film of sterilizing and itch-relieving Withdrawn CN107714825A (en)

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CN101428135A (en) * 2008-09-25 2009-05-13 成进学 Micro-element reinforced externally used liniment
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CN1857513A (en) * 2006-03-13 2006-11-08 张世麟 Chinese medicine composition for strengthening immunity, beautifying and treating skin disease
CN101204419A (en) * 2007-12-13 2008-06-25 张益军 Tincture medicine for neurodermitis
CN101428135A (en) * 2008-09-25 2009-05-13 成进学 Micro-element reinforced externally used liniment
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