CN108261440A - A kind of soft capsule for treating sow puerperal endometritis and preparation method thereof - Google Patents
A kind of soft capsule for treating sow puerperal endometritis and preparation method thereof Download PDFInfo
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- CN108261440A CN108261440A CN201611262972.3A CN201611262972A CN108261440A CN 108261440 A CN108261440 A CN 108261440A CN 201611262972 A CN201611262972 A CN 201611262972A CN 108261440 A CN108261440 A CN 108261440A
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- volatile oil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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Abstract
The present invention provides a kind of soft capsules for treating sow puerperal endometritis and preparation method thereof.The soft capsule is made of capsule material and liquid, and it is 100 that capsule material, which includes weight ratio,:40‑50:3‑8:90 100 sizing material, plasticizer, stabilizer and water, liquid are made of chlorhexidine acetate and volatile oil two parts, and the ratio of the two is 4:1（w/w）, the pharmaceutic adjuvant of 2.5 25wt% chlorhexidine acetates and 75 97.5 wt% composition, volatile oil part Mosla Chinensis Maxim volatile oil containing 70wt% and 30wt% pharmaceutic adjuvants are contained in chlorhexidine acetate part.The present invention is prepared as soft capsule and is applied to field of veterinary, intrauterine administration using the synergistic effect of chlorhexidine acetate and Mosla Chinensis Maxim volatile oil, for treating sow puerperal endometritis, medicine melts that become the time limit short, rapid-action, curative effect is high, and reliable in quality is easy to use.
Description
Technical field
The present invention relates to for treating the veterinary drug of dam disease, and in particular to a kind of beast for treating Gilt Uterus intimitis
With novel form --- soft capsule and preparation method thereof.
Background technology
Gilt Uterus intimitis is one of principal disease in pig breeding dysfunction disease, mainly invades sow by pathogenic microorganism
Uterine mucosa mucus and purulent inflammation caused by Uterine mucosa surface layer or deep layer, this disease are mainly in postpartum, if illness sow
Less than timely and effectively treating, often switch to recessive or chronic infection, lactation amount is reduced, agalasisa or milk quality are poor, is reluctant
Piglet lactation is given, suckling pig is caused to have loose bowels, depauperation；Oestrous cycle is disorderly, Repeat breeding, and farrowing is few, produces stillborn foetus, sucking pig
Many diseases such as yellowish-white dysentery occur, if after developing into intractable hysteritis, can increase production sow mortality, sow is easy
Secondary infection other diseases.Statistics shows that in large scale of pig farm produces more than 50% is by uterus in sow reproductive disease
Caused by intimitis, sow superseded due to endometritis accounts for the 48%~50% of total mortality every year.
Chlorhexidine acetate uterus injectant have broad-spectrum antibacterial, bactericidal effect, be treat pig, bovine endometritis it is good
Medicine.The product is the oleagenous suspension of plastics syringe packaging, due to prescription and technological reason, is susceptible to following problem：1)
Main ingredient is simply suspended in oleaginous base, not thorough enough to matrix research, the dissolution rate for easily leading to main ingredient from oleaginous base is low,
The pharmacological action of main ingredient cannot be given full play to.2) it is layered, redispersibility is poor, caking is easily precipitated in low temperature.After placing layering for a long time
Can not use state be reached by mixing again；Low temperature is easily demulsified, and drug is precipitated, and caking phenomenon occurs.3) biocompatibility
Difference, behind infusion of medicine uterus, it is easy to settle out, slow releasing function is not achieved.4) plastics syringe is packed, long-term to store, living
Fill in that the part that is contacted with syringe body is yielding to lead to leakage medicine.In addition, the product is when in use also there are some inconvenients,
It is mainly manifested in：1) head that plastics syringe seals need to be cut off when using；2) oleagenous suspension needs shake well equal before use
It is even；3) after having noted medicine, air or warm water need to be re-injected, to ensure that conduit does not have medicament residue.
Invention content
The present invention provides a kind of compound chlorhexidine acetate soft capsules, and chlorhexidine acetate and Mosla Chinensis Maxim volatile oil are compounded,
Suitable soft capsule is made in the form of microemulsion solution, soft capsule elasticity is suitable, and content is stablized, and overcomes chlorhexidine acetate
The deficiency of uterus injectant, uterus innerlich anwenden melt and become that the time limit is short, and rapid-action, curative effect is high, and reliable in quality is easy to use.
Another object of the present invention is to disclose a kind of preparation method of chlorhexidine acetate soft capsule preparation.
To achieve the above object, it adopts the following technical scheme that：
It is a kind of to be made of capsule material and liquid for treating the soft capsule of sow puerperal endometritis, Chinese medicine liquid medicine by
Water-soluble portion and volatile oil two parts composition containing chlorhexidine acetate, water-soluble portion and the two-part ratio of volatile oil are 4:
1 (w/w), water-soluble portion include 2.5-25wt% chlorhexidine acetates, 66-92.5wt%PEG400 (polyethylene glycol 400), 2-
9wt% propylene glycol and 0-5wt% glycerine；Volatile oil part is by 70wt% Mosla Chinensis Maxim volatile oils, 20wt% water and 10wt% polyoxies
Ethylene bay ether 58 forms.
Water-soluble portion is preferably by 25wt% chlorhexidine acetates, 66wt%PEG400 (polyethylene glycol 400), 9wt% third
Glycol forms.
It is above-mentioned for treating the soft capsule of sow puerperal endometritis, capsule material include sizing material, plasticizer, stabilizer and
Water, weight ratio 100:40-50:3-8:90-100.
The sizing material can make gelatin and/or Arabic gum；The plasticizer is glycerine, in propylene glycol, sorbierite
One kind or 2-3 kind compositions；Stabilizer is PEG400.
Preferably, sizing material is gelatin, and plasticizer is glycerine；Capsule material is 100 by mass ratio：40：3：100 gelatin, glycerine,
PEG400 and water composition.
Provided by the present invention for treating the soft capsule of sow puerperal endometritis, Chinese medicine liquid preparation method step
For：(1) water-soluble portion：PEG400, propylene glycol, glycerine are uniformly mixed, 70 DEG C is heated to, then adds in chlorhexidine acetate,
Stirring is complete to dissolving, and is uniformly mixed, and filters up to water-soluble portion；
(2) volatile oil part：Mosla Chinensis Maxim volatile oil, water and polyoxyethylene laurel ether 58 are weighed, is uniformly mixed to volatilize
Oily part；
(3) prepared by liquid：Under the conditions of 30 DEG C of temperature, mixing speed 3000r/min, volatile oil part is added in water-soluble
In partial solution, the microemulsion of clear is obtained.Conventional preparation process can be used in soft capsule.Using full-automatic rotating steel
Mould press is suppressed, and for dosage unit containing chlorhexidine acetate between 0.1-1g, preferably 1g is fragrant containing stone in the capsule material of every soft capsule
Ru volatile oil 0.7g.
Chlorhexidine acetate in the present invention has killing effect, but to tuberculosis to gram-positive bacteria, negative bacterium and fungi
Bacillus, bacterial spore and certain fungies only have bacteriostasis.Mosla Chinensis Maxim volatile oil not only causes a disease to mammalian endometritis
Bacterium (such as micrococcus scarlatinae, staphylococcus, Escherichia coli, proteus, suppurative corynebacteria, septic diplococcus and
Gangrenosum acne clostridium etc.) there is broad-spectrum antibacterial action, what is more important Mosla Chinensis Maxim volatile oil also has apparent anti-inflammatory effect,
Induced by endotoxin also has directly removing toxic substances deactivation.The two compounding will greatly be enhanced into anti-endometritis effect.
Compared with prior art, the present invention has the following advantages：
Scheme provided by the invention for treating sow puerperal endometritis, can effectively treat Gilt Uterus inner membrance
Inflammation chooses polyethylene glycol as filling compared with existing preparation chlorhexidine acetate uterus injectant (oleagenous suspension), in liquid
Agent, solubility very little of the chlorhexidine acetate in polyethylene glycol but is dissolved in propylene glycol and glycerine, and addition propylene glycol or glycerine etc. can
To improve the disintegrative of soft capsule, thus glycerine and propylene glycol as stabilizer while again as cosolvent, make acetic acid chlorine oneself
Fixed solubility increases and becomes solution, meanwhile, also have chosen the effective Chinese medical extract Mosla chinensis to endometritis simply
Volatile oil compounds therewith, and by the two successful formulation into the microemulsion of clear, stability is high, and medicine melts that become the time limit short, rapid-action,
Curative effect is high (cure rate up to 91.66%), reliable in quality.Curative effect is better than chlorhexidine acetate uterus injectant, and effect is good, and use is more square
Just, a large amount of manpower and materials are saved.
Chlorhexidine acetate soft capsule is applied and field of veterinary for the first time, for treating sow puerperal endometritis.System
It is standby simple for process, at low cost, suitable for large-scale industrial production.
Specific embodiment
The present invention is explained further with reference to embodiment.
Embodiment 1：
A kind of preparation method for the soft capsule for being used to treat sow puerperal endometritis, its step are as follows：
(1) 3700g polyethylene glycol 400s (92.5wt%), 80g propylene glycol (2wt%) and 120g glycerine (3wt%) are taken, is stirred
It mixes uniformly mixed, is heated to 70 DEG C, then add in 100g chlorhexidine acetates (2.5wt%), stirring is complete to dissolving, and filters to obtain the final product
Water-soluble portion containing chlorhexidine acetate.700g Mosla Chinensis Maxim volatile oils (70wt%) are weighed with 200g water (20wt%), 100g to gather
Ethylene oxide bay ether 58 (10wt%) is uniformly mixed and obtains volatile oil part.In 30 DEG C of temperature, mixing speed 3000r/min conditions
Under, volatile oil part is added in the solution of water-soluble portion, obtains the microemulsion of clear.
(2) 50 parts of 100 parts of gelatin, 90 parts, 8 parts PEG400 of purified water and glycerine are taken.Glycerine, purifying are put into glue tank to changing
Water, PEG400, are heated with stirring to 50-60 DEG C；Then jelly powder is at the uniform velocity put under agitation, is warming up to 70 DEG C, is treated gelatin
It after dissolving, stirs evenly, then is evacuated to vacuum outgas, obtain glue, 55-60 DEG C of heat preservation, set aside for use.
(3) it is suppressed using full-automatic rotating steel mold pressing machine, adjusts every 5g containing liquid, chlorhexidine acetate flexible glue is made
Capsule.Every 0.1g containing chlorhexidine acetate is measured, 0.7g containing Mosla Chinensis Maxim volatile oil is measured and 36min is limited to when melting change.
Embodiment 2：
A kind of preparation method for the soft capsule for being used to treat sow puerperal endometritis, its step are as follows：
(1) 3100g polyethylene glycol 400s (77.5wt%), 200g propylene glycol (5wt%) and 200g glycerine (5wt%) are taken, is stirred
It mixes uniformly mixed, is heated to 70 DEG C, then add in 500g chlorhexidine acetates (12.5wt%), stirring is complete to dissolving, mistake
It filters up to the water-soluble portion containing chlorhexidine acetate.By weighing 700g Mosla Chinensis Maxim volatile oils (70wt%) and 200g water
(20wt%), 100g polyoxyethylene laurel ethers 58 (10wt%) are uniformly mixed and obtain volatile oil part.In 30 DEG C of temperature, stirring speed
It spends under the conditions of 3000r/min, volatile oil part is added in the solution of water-soluble portion, obtains the microemulsion of clear.
(2) take 50 parts of gelatin, 50 parts of Arabic gum, 90 parts, 5 parts PEG400 of purified water, 30 parts of glycerine, 10 parts of propylene glycol and
10 parts of sorbierite；To input glycerine, propylene glycol, sorbierite, purified water and PEG400 in glue tank is changed, it is heated with stirring to 50-60 DEG C；
Then gelatin and gummi arabicum pulveratum are at the uniform velocity put under agitation, are warming up to 70 DEG C, after gelatin and Arabic colloid dissolve,
It stirs evenly, then is evacuated to vacuum outgas, obtain glue, 55-60 DEG C of heat preservation, set aside for use.
(3) it is suppressed using full-automatic rotating steel mold pressing machine, adjusts every 5g containing liquid, chlorhexidine acetate flexible glue is made
Capsule.Every 0.5g containing chlorhexidine acetate is measured, 0.7g containing Mosla Chinensis Maxim volatile oil is measured and 28min is limited to when melting change.
Embodiment 3：
A kind of preparation method for the soft capsule for being used to treat sow puerperal endometritis, its step are as follows：
(1) 2640g polyethylene glycol 400s (66wt%) are taken, 360g propylene glycol (9wt%) is uniformly mixed, is heated to 70
DEG C, 1000g chlorhexidine acetates (25wt%) are then added in, stirring is complete to dissolving, and filters up to containing the water-soluble of chlorhexidine acetate
Property part.By weighing 700g Mosla Chinensis Maxim volatile oils (70wt%) and 200g water (20wt%), 100g polyoxyethylene laurel ethers 58
(10wt%) is uniformly mixed and obtains volatile oil part.Under the conditions of 30 DEG C of temperature, mixing speed 3000r/min, by volatile oil portion
Divide and be added in the solution of water-soluble portion, obtain the microemulsion of clear.
(2) 40 parts of 100 parts of gelatin, 100 parts, 3 parts PEG400 of water and glycerine are taken.Other operations are the same as preparation example 1.
(3) it is suppressed using full-automatic rotating steel mold pressing machine, adjusts every 5g containing inner liquid medicine, chlorhexidine acetate flexible glue is made
Capsule.Every 1g containing chlorhexidine acetate is measured, 0.7g containing Mosla Chinensis Maxim volatile oil is measured and 23min is limited to when melting change.
Clinical efficacy contrast test
Material to be tested
For trying animal
300 sows that different degrees of endometritis is suffered from by judgement, body weight control is in 60kg or so.By its with
Machine is divided into two groups, and every group each 150, one group is chlorhexidine acetate uterus injectant group, and another group soft for compound chlorhexidine acetate
Capsules group.
Test method：
Compound chlorhexidine acetate soft capsule group：It is treated using the soft capsule of the embodiment of the present invention 3, intrauterine is used
Medicine：Once a grain, every repeated drug taking on the 3rd 1 time, is used in conjunction 4 times.
Chlorhexidine acetate injectant group：It is treated using commercially available chlorhexidine acetate injectant, uterus innerlich anwenden：Once
One, every repeated drug taking on the 3rd 1 time is used in conjunction 4 times.
Clinical efficacy judges
After first administration, systemic conditions observation is carried out to sow, 30d is observed continuously, and pass through cure rate, effective percentage and nothing
Efficiency judges the therapeutic effect of test group.Cure rate refers to after treatment, and the state of mind, body temperature and the appetite of sow are all
Restore normal, vagina is without redness, interior no rheuminess object and fester discharge, to cure；Effective percentage, refer to healing after completely restore with
The sum of sow number being clearly better.It is clearly better and refers to the state of mind, body temperature and the appetite of sow and return to normal, there is certain point
Secretion flows out but relatively transparent limpid, no fester discharge；Inefficiency, the state of mind, body temperature and the appetite for referring to sow are not all restored just
Often, intrauterine still has the discharge of inflammatory fester.
Efficacy result
The therapeutic effect that following table is two groups compares
As can be seen from the table, compound chlorhexidine acetate soft capsule group sow cures number and significant figure is apparently higher than acetic acid chlorine
The sow that oneself determines uterus injectant control group cures number and significant figure.Therefore, illustrate, compound chlorhexidine acetate flexible glue of the invention
Capsule, good effect, curative effect are good.
Citing：There are 60 sows on the Nanchong pig farm of 6 Chuan December in 2015 province days, million livestock technology Co., Ltd, occurs not
Body temperature with degree increases, lassitude, and anorexia or useless exhausted exerts duty often, especially when sow just keeps down, intravaginal stream
Go out white slimy or stick at root of the tail portion with the contaminated bronzing mucus of stink or purulent secretion, secretion, smell as of rotten fish unpleasant.Root
Gilt Uterus intimitis is diagnosed as according to bed symptom and test method, to the soft capsule of 60 sow feeding embodiments 3, once
1, every repeated drug taking on the 3rd 1 time is used in conjunction 4 times.Cure rate is 91.66%, and effective percentage follow-up half a year, is not recurred up to 95%.
Claims (7)
1. it is a kind of for treating the soft capsule of sow puerperal endometritis, it is made of capsule material and liquid, it is characterised in that：Liquid
It is made of the water-soluble portion containing chlorhexidine acetate and volatile oil two parts, water-soluble portion and the two-part ratio of volatile oil are
4:1 (w/w) contains 2.5-25wt% chlorhexidine acetates, 66-92.5wt%PEG400,2-9wt% propylene glycol in water-soluble portion
With 0-5wt% glycerine, volatile oil part Mosla Chinensis Maxim volatile oil containing 70wt% and 30wt% pharmaceutic adjuvants.
2. a kind of soft capsule for being used to treat sow puerperal endometritis, it is characterised in that：Volatile oil part is by 70wt% stones
Herba Moslae volatile oil, 20wt% water and 10wt% polyoxyethylene laurel ethers 58 form.
3. the soft capsule according to claim 1 for being used to treat sow puerperal endometritis, it is characterised in that：Described
It is 100 that capsule material, which includes weight ratio,:40-50:3-8:Sizing material, plasticizer, stabilizer and the water of 90-100.
4. the soft capsule according to claim 3 for being used to treat sow puerperal endometritis, it is characterised in that：Described
Sizing material is gelatin and/or Arabic gum.
5. the soft capsule according to claim 3 for being used to treat sow puerperal endometritis, it is characterised in that：Described
Plasticizer is glycerine, propylene glycol, one kind in sorbierite or 2-3 kind compositions.
6. the soft capsule according to claim 3 for being used to treat sow puerperal endometritis, it is characterised in that：Described
Stabilizer is PEG400.
7. it is used to treat the soft capsule of sow puerperal endometritis according to right 1-6 any one of them, it is characterised in that：Capsule
Dosage unit 0.1-1g containing chlorhexidine acetate, 0.7g containing Mosla Chinensis Maxim volatile oil in material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611262972.3A CN108261440B (en) | 2016-12-30 | 2016-12-30 | Soft capsule for treating postpartum endometritis of sow and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611262972.3A CN108261440B (en) | 2016-12-30 | 2016-12-30 | Soft capsule for treating postpartum endometritis of sow and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
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| CN108261440A true CN108261440A (en) | 2018-07-10 |
| CN108261440B CN108261440B (en) | 2020-10-27 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201611262972.3A Active CN108261440B (en) | 2016-12-30 | 2016-12-30 | Soft capsule for treating postpartum endometritis of sow and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110075156A (en) * | 2019-05-20 | 2019-08-02 | 武汉国粹医药科技有限公司 | A kind of application of elscholtiza micro-capsule and preparation method thereof and elscholtiza micro-capsule |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1463699A (en) * | 2002-06-07 | 2003-12-31 | 北京立时达药业有限公司 | A composition for treating animal endometritis |
| CN103040931A (en) * | 2012-11-19 | 2013-04-17 | 王丽君 | Chinese medicinal preparation for treating endometritis of mammal |
-
2016
- 2016-12-30 CN CN201611262972.3A patent/CN108261440B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1463699A (en) * | 2002-06-07 | 2003-12-31 | 北京立时达药业有限公司 | A composition for treating animal endometritis |
| CN103040931A (en) * | 2012-11-19 | 2013-04-17 | 王丽君 | Chinese medicinal preparation for treating endometritis of mammal |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110075156A (en) * | 2019-05-20 | 2019-08-02 | 武汉国粹医药科技有限公司 | A kind of application of elscholtiza micro-capsule and preparation method thereof and elscholtiza micro-capsule |
| CN110075156B (en) * | 2019-05-20 | 2021-10-15 | 武汉国粹医药科技有限公司 | Elsholtzia ciliata microcapsule, preparation method thereof and application of elsholtzia ciliata microcapsule |
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| CN108261440B (en) | 2020-10-27 |
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