CN103126917B - Bionic gynecologic care solution and its preparation method - Google Patents
Bionic gynecologic care solution and its preparation method Download PDFInfo
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- CN103126917B CN103126917B CN201310062784.6A CN201310062784A CN103126917B CN 103126917 B CN103126917 B CN 103126917B CN 201310062784 A CN201310062784 A CN 201310062784A CN 103126917 B CN103126917 B CN 103126917B
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Abstract
The invention discloses a bionic gynecologic care solution and its preparation method. The gynecologic care solution comprises antibacterial peptides and an artificial vaginal secretion solution having a pH value of 3.3-4.4, and the content of the antibacterial peptides in the artificial vaginal secretion solution is 0.1-10.0g/L; and the artificial vaginal secretion solution comprises an artificial body fluid and a thickening agent, and the content of the thickening agent in the artificial body fluid is 0.5-5.0g/L. The bionic gynecologic care solution adopts a bionic design, the artificial body fluid is treated as a solvent, is added with the thickening agent to adjust the viscosity, and is added with an acid or an alkali to adjust the pH value in order to obtain the artificial vaginal secretion solution similar to a human vaginal secretion solution in component, viscosity and pH, and the antibacterial peptides are selected as a as bactericide. The bionic gynecologic care solution does not have an abuse that a chemical bactericide chronically erodes the vaginal viscosity, does not excessively change the vaginal microenvironment or destroy the vaginal physiological balance, and can be used for intractable vaginitis treatment and daily vagina healthcare and disease prevention.
Description
Technical field
The invention belongs to external sterilizing drug world, specifically, the present invention relates to a kind of bionic-type gynecological nursing liquid and preparation method thereof.
Background technology
According to statistics, more than 75% women suffered from vaginitis at least one time, and much outbreak repeatedly, is difficult to radical cure.Mainly cause colpitic pathogenic bacteria adularescent candidiasis, infusorian, gonococcus.
The frequent lavation vagina of solution with suitable antibacterial to colpitic primary treatment and preventive means at present, more than severe patient is wanted the every day of lavation once.But all vaginal douches are at present mainly with chemical bactericide and ultra-pure water or normal saline preparation.Though chemical bactericide is to vaginal mucosa without acute toxicity and acute lesion, long-time Reusability can produce chronic erosion and infringement to vaginal mucosa, affects the physiological functions such as vaginal mucosa secretion, accelerates vaginal mucosa aging.In addition, form diverse antibacterial aqueous solution or normal saline solution with vaginal secretion, lavation vagina also can destroy the microenvironment of vagina repeatedly repeatedly, accelerates the aging of vagina, and vaginal dryness is arrived ahead of time, affects life quality.
Summary of the invention
Based on this, the object of the invention is to overcome the defect of above-mentioned prior art, a kind of novel bionic-type gynecological nursing liquid that is used for the treatment of female vagina and vagina health care is provided.
A kind of bionic-type gynecological nursing liquid, described gynecological nursing liquid comprises the artificial vagina juice of antibacterial peptide and pH=3.3～4.4, the content of described antibacterial peptide in artificial vagina juice is 0.1～10.0g/L; Described artificial vagina juice comprises artificial body fluid and thickening agent, and the content of described thickening agent in described artificial body fluid is 0.5～5.0g/L; Described artificial body fluid is composed of the following components:
Surplus is water.
In one of them embodiment, described artificial body fluid is composed of the following components:
Surplus is water.
In an embodiment, the content of described antibacterial peptide in described artificial vagina juice is 0.2g/L therein.
In an embodiment, the content of described thickening agent in described artificial body fluid is 2.5g/L therein.
In some embodiment, described thickening agent is hyaluronic acid, sodium alginate, polyvinyl alcohol, Polyethylene Glycol or sodium carboxymethyl cellulose therein.
In an embodiment, described thickening agent is hyaluronic acid therein.
The present invention also provides the preparation method of above-mentioned bionic-type gynecological nursing liquid, comprises the following steps:
(1) by soluble in water other components except antibacterial peptide, thickening agent, after stirring and evenly mixing, then the specified volume that adds water, obtain artificial body fluid;
(2) in above-mentioned artificial body fluid, add thickening agent to stir, regulating pH is 3.3～4.4, obtains artificial vagina juice;
(3) in above-mentioned artificial vagina juice, add antibacterial peptide, stir, the processing of homogenizer homogenizing, obtains bionic-type gynecological nursing liquid.
Bionic-type gynecological nursing liquid of the present invention, adopt Bionic Design, using artificial body fluid as solvent, again toward wherein adding thickening agent to regulate its viscosity, with its pH value of acid-alkali accommodation, obtain artificial vagina juice, vaginal secretion composition, viscosity, the pH of itself and human body are all close, then select antibacterial peptide as antibacterial.Antibacterial peptide is a kind of native protein polypeptide, formed by aminoacid, prove the effectively vaginitis pathogenic bacterium such as Killing Candida Albicans, infusorian and gonococcus, but harmless to human normal cell, naturally can as chemical bactericide, there be chronic erosion and infringement to vaginal mucosa.And artificial vagina juice is close with human vagina's secreting mucus, the physiological equilibrium that can excessively not change vagina microenvironment and destroy vagina, can not accelerate the aging of vaginal mucosa.Bionic-type gynecological nursing liquid of the present invention can be usually used in lavation vagina, can be used for prevention and treatment intractable vaginitis, also can be used for daily health caring, the cleaning and disinfection of woman vagina.
The specific embodiment
Describe the present invention in detail below in conjunction with specific embodiment.
The antibacterial peptide adopting in the present invention can be directed to commercially available, can be also the antibacterial peptide of purifying by conventional method of purification, can also be by the synthetic antibacterial peptide obtaining of conventional synthetic method.
Following raw material all derives from commercially available, and wherein antibacterial peptide derives from Hai Na river Pharmaceutical.
Embodiment 1 bionic-type gynecological nursing liquid
The bionic-type gynecological nursing liquid of the present embodiment is composed of the following components:
Add water to 1L.
The preparation method of the bionic-type gynecological nursing liquid of the present embodiment is as follows:
(1) take each composition by formula, by other compositions except antibacterial peptide and medical hyaluronic acid, first use 800ml dissolved in purified water, and then add water to 1000ml; Obtain artificial body fluid;
(2) add medical hyaluronic acid 1.0g, stir; Regulating pH is 3.3～4.4, obtains artificial vagina juice;
(3) add antibacterial peptide 0.2g, stir, with the processing of homogenizer homogenizing, to obtain final product.
Embodiment 2 bionic-type gynecological nursing liquid
The bionic-type gynecological nursing liquid of the present embodiment is composed of the following components:
Add water to 1L.
The preparation method of the bionic-type gynecological nursing liquid of the present embodiment is as follows:
(1) take each composition by formula, by other compositions except antibacterial peptide and medical hyaluronic acid, first use 800ml dissolved in purified water, and then add water to 1000ml; Obtain artificial body fluid;
1, add medical hyaluronic acid 2.0g, stir; Regulating pH is 3.3～4.4, obtains artificial vagina juice;
2, add antibacterial peptide 0.2g, stir, with the processing of homogenizer homogenizing, to obtain final product.
Embodiment 3 bionic-type gynecological nursing liquid
The bionic-type gynecological nursing liquid of the present embodiment is composed of the following components:
Add water to 1L.
The preparation method of the bionic-type gynecological nursing liquid of the present embodiment is as follows:
(1) take each composition by formula, by other compositions except antibacterial peptide and PEG-4000, first use 800ml dissolved in purified water, and then add water to 1000ml; Obtain artificial body fluid;
(2) add PEG-4000 1.5g, stir; Regulating pH is 3.3～4.4, obtains artificial vagina juice;
(3) add antibacterial peptide 0.2g, stir, with the processing of homogenizer homogenizing, to obtain final product.
Embodiment 4 bionic-type gynecological nursing liquid
The bionic-type gynecological nursing liquid of the present embodiment is composed of the following components:
Add water to 1L.
The preparation method of the bionic-type gynecological nursing liquid of the present embodiment is as follows:
(1) take each composition by formula, by other compositions except antibacterial peptide and sodium alginate, first use 800ml dissolved in purified water, and then add water to 1000ml; Obtain artificial body fluid;
(2) add sodium alginate 1.6g, stir; Regulating pH is 3.3～4.4, obtains artificial vagina juice;
(3) add antibacterial peptide 0.2g, stir, with the processing of homogenizer homogenizing, to obtain final product.
By the vagina lavation for vaginitis patient by the bionic-type gynecological nursing liquid of embodiment 1-4, find, the bionic-type gynecological nursing liquid of embodiment 1-4 is the vaginitis pathogenic bacterium such as Killing Candida Albicans, infusorian and gonococcus effectively, vaginal mucosa is not corroded and damaged, the physiological equilibrium that can excessively not change vagina microenvironment and destroy vagina, can not accelerate the aging of vaginal mucosa yet.
The above embodiment has only expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but can not therefore be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (7)
1. a bionic-type gynecological nursing liquid, is characterized in that, described gynecological nursing liquid comprises the artificial vagina juice of antibacterial peptide and pH=3.3～4.4, and the content of described antibacterial peptide in artificial vagina juice is 0.1～10.0g/L; Described artificial vagina juice comprises artificial body fluid and thickening agent, and the content of described thickening agent in described artificial body fluid is 0.5～5.0g/L; Described artificial body fluid is composed of the following components:
2. bionic-type gynecological nursing liquid according to claim 1, is characterized in that, described artificial body fluid is composed of the following components:
3. bionic-type gynecological nursing liquid according to claim 1 and 2, is characterized in that, the content of described antibacterial peptide in described artificial vagina juice is 0.2g/L.
4. bionic-type gynecological nursing liquid according to claim 1 and 2, is characterized in that, the content of described thickening agent in described artificial body fluid is 2.5g/L.
5. bionic-type gynecological nursing liquid according to claim 1 and 2, is characterized in that, described thickening agent is hyaluronic acid, sodium alginate, polyvinyl alcohol, Polyethylene Glycol or sodium carboxymethyl cellulose.
6. bionic-type gynecological nursing liquid according to claim 5, is characterized in that, described thickening agent is hyaluronic acid.
7. a preparation method for the bionic-type gynecological nursing liquid as described in claim 1-6 any one, is characterized in that, comprises the following steps:
(1) by NaCl, KCl, CaCl
2, NaHCO
3, MgCl
26H
2o, MgSO
47H
2o, KH
2pO
4, Na
2pHO
412H
2o and glucose are soluble in water, after stirring and evenly mixing, then the specified volume that adds water, obtain artificial body fluid;
(2) in above-mentioned artificial body fluid, add thickening agent to stir, regulating pH is 3.3～4.4, obtains artificial vagina juice;
(3) in above-mentioned artificial vagina juice, add antibacterial peptide, stir, homogenizing processing, obtains bionic-type gynecological nursing liquid.
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105999224B (en) * | 2016-05-11 | 2017-06-16 | 广东科玮生物技术股份有限公司 | A kind of biomimetic type gynaecologic washing lotion and preparation method thereof |
| CN107184955A (en) * | 2017-06-05 | 2017-09-22 | 深圳肽护科技有限公司 | A kind of Ms's care composition containing polypeptide and preparation method thereof |
| CN110448570A (en) * | 2018-05-07 | 2019-11-15 | 易金阳 | A kind of microelement osmotic pressure feed with balanced nutrients component and Preparing Use |
| CN109395062B (en) * | 2018-12-29 | 2021-12-14 | 广州肽然生物科技有限公司 | Female pudendum sterilization care solution |
| KR102097265B1 (en) * | 2019-09-02 | 2020-04-06 | 코스맥스 주식회사 | A cosmetic composition comprising electrolytes for hydration and skin barrier |
| CN113995685A (en) * | 2021-11-09 | 2022-02-01 | 宋沂泓 | Vinegar-salt secondary polishing and protecting flushing fluid and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101181636A (en) * | 2006-11-14 | 2008-05-21 | 北京金迪克生物技术研究所 | Compound vaccine composition for preventing and controlling human viral infection, compound vaccine vaginal mist and uses thereof |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101181636A (en) * | 2006-11-14 | 2008-05-21 | 北京金迪克生物技术研究所 | Compound vaccine composition for preventing and controlling human viral infection, compound vaccine vaginal mist and uses thereof |
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Inventor after: Xu Guofeng Inventor before: Chen Songbin Inventor before: Xu Huihua |
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Effective date of registration: 20160427 Address after: 510627 Guangdong city of Guangzhou province Tianhe District Whampoa Road West, No. 601 and Suzhou court 3 Building Patentee after: Xu Guofeng Address before: 510730 Guangzhou Province, free trade zone, Guangdong Avenue, No. 301, room 39 Patentee before: Guangzhou Cooway Biotechnology Co.,Ltd. |
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Effective date of registration: 20200810 Address after: 530000 the third floor of building B2, Nanning Ecological Industrial Park, 110 Zhenxing Road, XiXiangTang District, Nanning City, Guangxi Zhuang Autonomous Region Patentee after: Guangxi Wan Hao Biological Technology Co.,Ltd. Address before: 510627 Guangdong city of Guangzhou province Tianhe District Whampoa Road West, No. 601 and Suzhou court 3 Building Patentee before: Xu Guofeng |
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