CN108210844A - 一种治疗慢性前列腺炎的胶囊剂药物及制备方法 - Google Patents
一种治疗慢性前列腺炎的胶囊剂药物及制备方法 Download PDFInfo
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Abstract
本发明属于中药制剂领域,目的是根据中医治疗慢性前列腺炎的认识机理而提供一种治疗慢性前列腺炎的胶囊剂药物,所述药物的各个组分及其质量份比如下:虎杖100~160g、丹参80~160g、赤芍60~160g、花蛇舌草150~650g、泽兰60~150g、桃仁80~160g、莪术30~120g、鳖甲100~260g、金银花100~250g、败酱草100~360g、淫羊藿30~100g、茯苓100~180g、泽泻60~100g、黄茋100~350g、大枣100~160g、王不留行80~160g、枸杞子50~160g、红花50~120g;本发明提供的药物是一个很好的中药组方。
Description
技术领域
本发明属于中药制剂领域,具体涉及一种治疗慢性前列腺炎的胶囊剂药物,特别是供慢性前列腺炎患者使用的胶囊剂药物及制备方法的领域。
背景技术
医者认为:慢性前列腺炎是一种常见的泌尿型生殖型疾病,主要包括慢性细菌性前列腺炎和非细菌性前列腺炎。发病率极高并且让人十分困惑。近50%的男性都会遭遇前列腺炎的影响。需要对症下药,减轻病痛。根据患者的病理、病因,选择去症治疗是最有效可行的方法。由于临床症状复杂多样,并对男性性功能和生育功能都有一定影响,严重地阻碍了患者的生活质量,使他们的精神与肉体受到极大的折磨。
慢性前列腺炎的病因十分复杂,尽管对其发病机制有了一定认识,但没有突破性进展。目前认为:慢性前列腺炎可能是由前列腺及其周围组织器官、肌肉和神经的原发性或继发性引起的疾病,甚至于在这些疾病已经治愈或彻底根除后,它所造成的损害与病理改变仍然在独立地持续起作用,其病因的中心可能是感染、炎症和异常的盆底神经肌肉活动的共同作用。
那么,就如何找到一种可有效治疗慢性前列腺炎的中药组合物,是本领域技术人员亟待要解决的问题。
发明内容
随着我国中医中药学的不断发展,在治疗慢性前列腺炎上,人们逐渐意识到了中医治疗慢性前列腺炎的优点,且在治疗过程中疗效好、见效快、毒副作用小等优势,针对现有西医治疗慢性前列腺炎的现状,本发明的目的是在于提供一种治疗慢性前列腺炎的胶囊剂药物,以解决慢性前列腺炎患者早日恢复健康的问题。该药物是以常见的中药为原料,通过选择合理的药物及质量份比,可有效治疗上述慢性前列腺炎。
为达到上述发明的目的,本发明所采用的技术方案为:提供一种治疗慢性前列腺炎的胶囊剂药物及制备方法,其特征在于,所述药物的各个组分及质量份比如下所示:
虎杖100~160g、丹参80~160g、赤芍60~160g、花蛇舌草150~650g、泽兰60~150g、桃仁80~160g、莪术30~120g、鳖甲100~260g、金银花100~250g、败酱草100~360g、淫羊藿30~100g、茯苓100~180g、泽泻60~100g、黄茋100~350g、大枣100~160g、王不留行80~160g、枸杞子50~160g、红花50~120g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
一种治疗慢性前列腺炎的胶囊剂药物及制备方法,其特征在于,所述药物的各个组分及质量份比如下所示:
虎杖115~140g、丹参90~140g、赤芍70~140g、花蛇舌草180~560g、泽兰70~130g、桃仁90~140g、莪术36~105g、鳖甲115~230g、金银花115~220g、败酱草115~320g、淫羊藿36~90g、茯苓115~160g、泽泻70~90g、黄茋115~310g、大枣115~140g、王不留行90~140g、枸杞子56~140g、红花56~105g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
一种治疗慢性前列腺炎的胶囊剂药物及制备方法,其特征在于,所述药物的各个组分及质量份比如下所示:
虎杖120g、丹参120g、赤芍120g、花蛇舌草500g、泽兰118g、桃仁120g、莪术95g、鳖甲200g、金银花200g、败酱草260g、淫羊藿80g、茯苓140g、泽泻80g、黄茋260g、大枣120g、王不留行120g、枸杞子120g、红花95g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
一种治疗慢性前列腺炎的胶囊剂药物及制备方法,其特征在于,所述方法包括如下步骤制备而成:
A、将上述原料中药拣去杂质和粉尘后,按照质量份比共粉碎成(30~50目)颗粒状包煎;
B、①将包好的原料中药放入冷开水中浸泡50min,然后再将浸泡好的药物放入砂锅内,加入原料中药重量8~10倍的冷开水进行第一次武火煎煮,待煎煮到18min时,转文火熬制120min,滤取药液;②药渣中再次加入原料中药重量7~9 倍的冷开水进行第二次武火煎煮,待煎煮到15min时,转文火熬制110min,滤取药液;③将二次药液混合浓缩成相对密度为1.08 的清膏,然后干燥、研末和消毒后备用;
C、①按照传统制备中药胶囊剂的方法,将B中研磨好的细末过筛后,加入适量的微粉硅胶、微晶纤维素和淀粉混合均匀,然后制备成胶囊剂(其胶囊锁合后总长度为23.3mm,药粉容量0.4~0.5g/粒),②继而抛光,消毒,分装密封即可。
一种治疗慢性前列腺炎的胶囊剂药物及制备方法,其特征在于,所述服用方法为:将制备好的胶囊剂药物以每日三次服用,早中晚各服一次,给药量2g(4粒)/次,温开水送服。30天为一个疗程,服药1~3个疗程,炎症消失,病获痊愈。
本发明组方中的各原料中药在中国药典、中国辞典以及中华本草中均有详细的记载。本发明选用其中最常见的中药为原料,充分发挥各组分的药理功效:
虎杖,性味:味微苦、性微寒,具有利湿退黄、清热解毒、散瘀止痛、止咳化痰之功效,用于治疗湿热黄疸、淋浊、带下、风湿痹痛、痈肿疮毒、水火烫伤、经闭、症瘕、趺打损伤、肺热咳嗽;
丹参,性味:味苦、性微寒,具有活血祛瘀、调经止痛、养血安神、凉血消痈之功效,用于治疗妇女月经不调、痛经、经闭、产后瘀滞腹痛、心腹疼痛、症瘕积聚、热痹肿痛、跌打损伤、热入营血、烦躁不安、心烦失眠、痈疮肿毒;
赤芍,性味:苦、微寒,具有清热凉血、活血祛瘀之功效,用于治疗温毒发斑、吐血衄血、肠风下血、目赤肿痛、痈肿疮疡、闭经、痛经、崩带淋浊、瘀滞胁痛、疝瘕积聚、跌扑损伤;
花蛇舌草,性味:味微苦、性寒,具有清热解毒、利湿通淋之功效,用于治疗肺热喘咳、咽喉肿痛、肠痈、疖肿疮疡、毒蛇咬伤、热淋涩痛、水肿、痢疾、肠炎、湿热黄疸、癌肿等症;
泽兰,性味:味苦、辛、性微温,具有活血化瘀、行水消肿、解毒消痈之功效,用于治疗妇女经闭、痛经、产后瘀滞腹痛、癥瘕浮肿、跌打损伤、痈肿疮毒;
桃仁,性味:苦甘、平,无毒,具有破血行瘀、润燥滑肠之功效,用于治疗经闭、癥瘕、热病蓄血、风痹、疟疾、跌打损伤、瘀血肿痛、血燥便秘等症;
莪术,性味:味辛、苦、性温,具有行气破血、消积止痛之功效,用于治疗血气心痛、饮食积滞、脘腹胀痛、血滞经闭、痛经、症瘕瘤痞块、跌打损伤;
鳖甲,性味:味咸、性微寒,具有滋阴潜阳、退热除蒸、软坚散结之功效,用于治疗阴虚发热、骨蒸劳热、阴虚阳亢、头晕目眩、虚风内动、经闭、癥瘕、久疟、疟母等症;
金银花,性味:甘、寒,具有清热解毒之功效,用于治疗温病发热、热毒血痢、痈肿疔疮、喉痹及多种感染性疾病;
败酱草,性味:苦、寒,具有清热解毒、活血散瘀排脓之功效,用于治疗肠痈、肺痈、急性菌痢、急性咽炎、急性阑尾炎;
淫羊藿,性味:味辛、甘、性温,具有补肾壮阳、祛风除湿、强筋键骨之功效,用于治疗阳痿遗精、虚冷不育、尿频失楚、肾虚喘咳、腰膝酸软、风湿痹痛、半身不遂、四肢不仁;
茯苓,性味:味甘、淡、性平,具有利水渗湿、健脾、宁心之功效,用于治疗水肿尿少、痰饮眩悸、脾虚食少、便溏泄泻、心神不安、惊悸失眠;
泽泻,性味:甘、寒,具有利小便、清湿热之功效,用于治疗小便不利、水肿胀满、泄泻尿少、痰饮眩晕、热淋涩痛、高血脂等症;
黄茋,性味:甘、微温,具有补气固表、利尿托毒、排脓、敛疮生肌之功效,用于治疗气虚乏力、食少便溏、中气下陷、久泻脱肛、便血崩漏、表虚自汗、气虚水肿、痈疽难溃、久溃不敛、血虚痿黄、内热消渴、慢性肾炎蛋白尿、糖尿病;
大枣,性味:甘、温,具有补脾胃、益气血、安心神、调营卫、和药性之功效,用于治疗脾胃虚弱、气血不足、食少便溏、倦怠乏力、心悸失眠、妇人脏躁、营卫不和等症;
王不留行,性味:苦、平,具有行血通经、催生下乳、消肿敛疮之功效,用于治疗妇女经闭、乳汁不通、难产、血淋、金疮出血、通经下乳、活血消肿、瘀血肿块、疮痈肿毒;
枸杞子,性味:味甘、性平,具有养肝、滋肾、润肺之功效,用于治疗肝肾亏虚、头晕目眩、目视一清、腰膝酸软、阳痿贵精、虚劳咳嗽、消渴引饮等症;
红花,性味:味辛、性温,具有活血能经、祛瘀止痛之功效,用于治疗经闭、痛经、产后瘀阻腹痛、胞痹心痛症瘕积聚、跌打损伤、关节疼痛、中风偏竣、斑疹等症。
本发明药物是基于中医治疗慢性前列腺炎的原则,从依据慢性前列腺炎的病理机制及药理作用认为:就慢性前列腺炎,本发明所提供的药物中的各原料中药药效共奏,对上述疾病有很好的治疗效果。
具体实施方式
本发明就是针对上述慢性前列腺炎的治疗而提出的一种中药配方,采用该配方制备的药物药效好,见效快,是一个很好的中药组方,特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述:
实施例1:
一种治疗慢性前列腺炎的胶囊剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
虎杖120g、丹参120g、赤芍120g、花蛇舌草500g、泽兰118g、桃仁120g、莪术95g、鳖甲200g、金银花200g、败酱草260g、淫羊藿80g、茯苓140g、泽泻80g、黄茋260g、大枣120g、王不留行120g、枸杞子120g、红花95g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
实施例2:
一种治疗慢性前列腺炎的胶囊剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
虎杖140g、丹参140g、赤芍140g、花蛇舌草560g、泽兰130g、桃仁140g、莪术105g、鳖甲230g、金银花220g、败酱草320g、淫羊藿90g、茯苓160g、泽泻90g、黄茋310g、大枣140g、王不留行140g、枸杞子140g、红花105g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
实施例3:
一种治疗慢性前列腺炎的胶囊剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
虎杖140g、丹参140g、赤芍140g、花蛇舌草560g、泽兰130g、桃仁140g、莪术105g、鳖甲230g、金银花220g、败酱草320g、淫羊藿90g、茯苓160g、泽泻90g、黄茋310g、大枣140g、王不留行140g、枸杞子140g、红花105g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
典型病例:
经临床诊断治疗慢性前列腺炎患者共1250例,年龄为55岁以上的642例,只有608例为55岁以下。1250例患者中痊愈的有1015例,有效的147例,无效的88例。总有效率达93%。
Claims (3)
1.一种治疗慢性前列腺炎的胶囊剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
虎杖100~160g、丹参80~160g、赤芍60~160g、花蛇舌草150~650g、泽兰60~150g、桃仁80~160g、莪术30~120g、鳖甲100~260g、金银花100~250g、败酱草100~360g、淫羊藿30~100g、茯苓100~180g、泽泻60~100g、黄茋100~350g、大枣100~160g、王不留行80~160g、枸杞子50~160g、红花50~120g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
2.根据权利要求1所述的治疗慢性前列腺炎的胶囊剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
虎杖115~140g、丹参90~140g、赤芍70~140g、花蛇舌草180~560g、泽兰70~130g、桃仁90~140g、莪术36~105g、鳖甲115~230g、金银花115~220g、败酱草115~320g、淫羊藿36~90g、茯苓115~160g、泽泻70~90g、黄茋115~310g、大枣115~140g、王不留行90~140g、枸杞子56~140g、红花56~105g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
3.根据权利要求1至2所述的治疗慢性前列腺炎的胶囊剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
虎杖120g、丹参120g、赤芍120g、花蛇舌草500g、泽兰118g、桃仁120g、莪术95g、鳖甲200g、金银花200g、败酱草260g、淫羊藿80g、茯苓140g、泽泻80g、黄茋260g、大枣120g、王不留行120g、枸杞子120g、红花95g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
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