CN108210419A - A kind of rush penetrative composition - Google Patents
A kind of rush penetrative composition Download PDFInfo
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- CN108210419A CN108210419A CN201810204406.XA CN201810204406A CN108210419A CN 108210419 A CN108210419 A CN 108210419A CN 201810204406 A CN201810204406 A CN 201810204406A CN 108210419 A CN108210419 A CN 108210419A
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- composition
- extract
- permeation enhancers
- moisturizer
- allergic agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention disclose a kind of rush penetrative composition, including permeation enhancers, moisturizer, anti-allergic agent ingredient, wherein, permeation enhancers be capsaicine, Rhizoma Sparganii extract, menthol, borneol, dimethyl sulfoxide (DMSO) and its homologue in one or more.The present invention is promoted penetrative composition to apply in cosmetics, is not stimulated mildly, effectively facilitates active material skin permeation deep layer, helps percutaneous absorption nutritional ingredient.
Description
Technical field
The present invention relates to cosmetic fields, and in particular to a kind of rush penetrative composition.
Background technology
Skin is human body and the barrier of external environment, and under normal circumstances, foreign substance is difficult to transdermal cuticula, nothing
In active component due effect occurs for method.Therefore, in order to which skin barrier is overcome to act on, active ingredient is promoted to enter skin depth
Layer so as to play Skin Cell the adjustment effect of various physiologicals, usually needs to add when skin care item and drug are prepared
Certain permeation enhancers is added to increase effective ingredient transdermal absorption factor.But general chemical enhancers, as azone, surface are lived
Property agent, organic acid etc., easily cause skin allergy, for a long time or large dosage of use can damage skin.In recent years, come
Derived from natural plants permeation enhancers are because of its action temperature and toxic side effect is small has been to be concerned by more and more people.
Invention content
The purpose of the present invention is to provide a kind of rush penetrative compositions, are alternatively arranged as additive for moisturizing infiltration class production
Product play Penetration enhancing effect, improve the utilization rate of active constituent.
In order to achieve the above object, the present invention provides following technical solution：
A kind of rush penetrative composition includes the component of following mass parts：
Permeation enhancers 3.5-10
Moisturizer 5-8
Anti-allergic agent 0.5-4.5
Wherein, permeation enhancers is in capsaicine, Rhizoma Sparganii extract, menthol, borneol, dimethyl sulfoxide (DMSO) and its homologues
It is one or more kinds of.
Further, the composition includes the ingredient of following mass parts：
Permeation enhancers 3.5-10
Moisturizer 5-8
Anti-allergic agent 0.5-4.5
Wherein, permeation enhancers is in capsaicine, Rhizoma Sparganii extract, menthol, borneol, dimethyl sulfoxide (DMSO) and its homologues
It is one or more kinds of.
Further, the composition includes the component of following mass parts：
Permeation enhancers 3.5-10
Moisturizer 5-8
Anti-allergic agent 0.5-4.5
Wherein, permeation enhancers is in capsaicine, Rhizoma Sparganii extract, menthol, borneol, dimethyl sulfoxide (DMSO) and its homologues
It is one or more kinds of.
In addition, the moisturizer includes saualane, glucan, glycerine, hyaluronic acid, one kind or one kind in ceramide
More than；
The anti-allergic agent includes cogongrass rhizome extractive, dipotassium glycyrrhizinate, brown alga extract, Xuelianhuangtong, chamomile and carries
Take the one or more in object, aloe vera extract.
Composition of the present invention can be used for cosmetics, can such as additive is used as to permeate class product for moisturizing.
Compared with prior art, the present invention has following advantageous effect：
(1) add permeation enhancers, capsaicine, Rhizoma Sparganii extract have improving micro_circulation effect, can Cucumber Extract, promote
Active material infiltrates through skin, and dimethyl sulfoxide (DMSO) and its homologue make active ingredient be more easy to the deep layer of skin permeation, improve effective
The absorptivity of ingredient；
(2) moisturizer is added, while moisturizing moisturizing, moreover it is possible to which collaboration promotes to absorb；
(3) anti-sensitizer provided is natural plant ingredient, not only with good antiallergic effect, good penetrability, moreover it is possible to
The absorption of other ingredients is driven, the camomile extract energy Shu Min provided and reparation skin can balance the colour of skin and replenishing water and preserving moisture.
(4) present invention is promoted penetrative composition to apply in cosmetics, is not stimulated mildly, effectively facilitate active material infiltration
Deep skin helps percutaneous absorption nutritional ingredient.
Specific embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
Promote the preparation of penetrative composition：
By 1.5 grams of capsaicines, 2.5 grams of Rhizoma Sparganii extracts, 2 grams of dimethyl sulfoxide (DMSO)s and its homologue, 6 grams of glucans, 2.5 grams
Brown alga extract and 85.5 grams of deionized waters are placed in mixer, are uniformly mixed, you can obtain the rush osmotic composition
Object.
Embodiment 2
Human body patch is tested
Organize 50 volunteers according to《Cosmetics health specification》The human skin patch Experimental Standardization of (2007 editions) records,
The rush penetrative composition obtained by the embodiment of the present invention 1 is tested, the results are shown in Table 1.
Table 1
The rush penetrative composition obtained of embodiment 1 is nonirritant to human skin as can be seen from Table 1.
Embodiment 3
Promote evaluation of permeating experiment
Test specimen：It is obtained above to promote penetrative composition, deionized water
Experimental subjects：Female small white mouse
Experimental method：Two kinds of samples are divided into two groups, choose 10 female small white mouses respectively, carry out separating label, at every
15g samples are smeared at small white mouse mammary gland position daily, are smeared in three times, continuous to smear 15 days, observe each small white mouse mammary gland increase
Situation the results are shown in Table 2.
Table 2
As known from Table 2, it was observed continuously by 15 days, the small white mouse mammary gland for smearing rush penetrative composition averagely increases
8.062%, the small white mouse mammary gland for smearing deionized water averagely increases 2.039%, it is seen that promoting penetrative composition, there is promotion to permeate
Effect.
Embodiment 4
The preparation of moisturizing emulsion：
According to mass percent, by 3% glycerine, 0.4% xanthans, the smooth stearate of 2% sorb, 3% sucrose coconut oil
Ester and 61.2% deionized water, which are mixed evenly, is heated to 85 DEG C up to water phase, by 9% caprylic/capric triglyceride, 4%
White oil and 2% stearyl alcohol are mixed evenly heating and are heated to 85 DEG C up to oil phase, and gained oil phase is continued under vacuum
Stirring, then adds in water phase, and continue to stir and emulsify into oil phase, after emulsification, continues insulated and stirred 15min, is cooled to 40
Lemon acid for adjusting pH is added in after DEG C to neutrality, adds 0.2% Phenoxyethanol, 15% above-mentioned rush penetrative composition and 0.2%
Essence is stirred to get moisturizing emulsion.
Comparative example 1
Difference lies in do not add above-mentioned rush penetrative composition, other prepare item with embodiment 4 in the formula of comparative example 1
Part is with method with embodiment 4.
Embodiment 5
Promote chemosmotic effect experiment
By lotion made from above-described embodiment 4 and comparative example 1, while using a commercially available moisturizing emulsion as control group, point
It is not tried out through the 100 of 20~35 personnel.The apparent number of moistening effect was recorded respectively on probation 0,7,14,21,28 day.Knot
Fruit is shown in Table 3.
Table 3
The moistening effect of embodiment 4 is apparently higher than other groups as known from Table 3；Show that promoting penetrative composition has preferable rush
The effect of oozing allows the skin to quickly absorb nutritional ingredient, reaches preferable moisturizing degree.
Above example is merely to illustrate embodiment of the present invention, and there is no the limits having to the present invention in any form
System；It is any to be engaged in professional and technical personnel, it all has the ability using the technology contents having revealed that, some is made to it and changes or repaiies
Decorations become the equivalent embodiment of equivalent variations.According to the technology of the present invention essence, simply modification, equivalent variations are carried out to the present invention
With modification, belong in the range of technical solution of the present invention.
Claims (10)
1. a kind of rush penetrative composition, it is characterised in that component and content are：
Permeation enhancers 3.5-10
Moisturizer 5-8
Anti-allergic agent 0.5-4.5
It is mass parts above；
Wherein, permeation enhancers are one kind in capsaicine, Rhizoma Sparganii extract, menthol, borneol, dimethyl sulfoxide (DMSO) and its homologue
Or more.
2. composition as described in claim 1, it is characterised in that component and content are：
Permeation enhancers 3.5-10
Moisturizer 5-8
Anti-allergic agent 0.5-4.5
It is mass parts above；
Wherein, permeation enhancers are one kind in capsaicine, Rhizoma Sparganii extract, menthol, borneol, dimethyl sulfoxide (DMSO) and its homologue
Or more.
3. composition as described in claim 1, it is characterised in that component and content are：
Permeation enhancers 3.5-10
Moisturizer 5-8
Anti-allergic agent 0.5-4.5
It is mass parts above；
Wherein, permeation enhancers are one kind in capsaicine, Rhizoma Sparganii extract, menthol, borneol, dimethyl sulfoxide (DMSO) and its homologue
Or more.
4. composition as described in claim 1, it is characterised in that：
The moisturizer includes one or more of in saualane, glucan, glycerine, hyaluronic acid, ceramide；
The anti-allergic agent include cogongrass rhizome extractive, dipotassium glycyrrhizinate, brown alga extract, Xuelianhuangtong, camomile extract,
It is one or more of in aloe vera extract.
5. composition as claimed in claim 2, it is characterised in that：
The moisturizer includes one or more of in saualane, glucan, glycerine, hyaluronic acid, ceramide；
The anti-allergic agent include cogongrass rhizome extractive, dipotassium glycyrrhizinate, brown alga extract, Xuelianhuangtong, camomile extract,
It is one or more of in aloe vera extract.
6. composition as claimed in claim 3, it is characterised in that：
The moisturizer includes one or more of in saualane, glucan, glycerine, hyaluronic acid, ceramide；
The anti-allergic agent include cogongrass rhizome extractive, dipotassium glycyrrhizinate, brown alga extract, Xuelianhuangtong, camomile extract,
It is one or more of in aloe vera extract.
7. composition as described in claim 1, it is characterised in that available for cosmetics.
8. composition as claimed in claim 2, it is characterised in that available for cosmetics.
9. composition as claimed in claim 3, it is characterised in that available for cosmetics.
10. such as claims 1 to 3 any one of them composition, it is characterised in that additive can be used as to permeate class for moisturizing
Product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810204406.XA CN108210419A (en) | 2018-03-13 | 2018-03-13 | A kind of rush penetrative composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810204406.XA CN108210419A (en) | 2018-03-13 | 2018-03-13 | A kind of rush penetrative composition |
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| Publication Number | Publication Date |
|---|---|
| CN108210419A true CN108210419A (en) | 2018-06-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810204406.XA Withdrawn CN108210419A (en) | 2018-03-13 | 2018-03-13 | A kind of rush penetrative composition |
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| CN (1) | CN108210419A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108888581A (en) * | 2018-08-01 | 2018-11-27 | 江苏朗沁科技有限公司 | A kind of transdermal absorbing composition and its application |
| CN110192985A (en) * | 2019-06-26 | 2019-09-03 | 广州市百爱神生物科技有限公司 | A kind of care agent and preparation method thereof for skin moisture-keeping reparation |
| CN111743852A (en) * | 2019-03-29 | 2020-10-09 | 傅柏舜 | Composition for making macromolecular medicine pass through skin |
| CN118161430A (en) * | 2024-02-22 | 2024-06-11 | 广州今盛美精细化工有限公司 | Skin care composition and preparation method and application thereof |
-
2018
- 2018-03-13 CN CN201810204406.XA patent/CN108210419A/en not_active Withdrawn
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108888581A (en) * | 2018-08-01 | 2018-11-27 | 江苏朗沁科技有限公司 | A kind of transdermal absorbing composition and its application |
| CN111743852A (en) * | 2019-03-29 | 2020-10-09 | 傅柏舜 | Composition for making macromolecular medicine pass through skin |
| CN111743852B (en) * | 2019-03-29 | 2022-10-28 | 傅柏舜 | Composition for making macromolecular medicine pass through skin |
| CN110192985A (en) * | 2019-06-26 | 2019-09-03 | 广州市百爱神生物科技有限公司 | A kind of care agent and preparation method thereof for skin moisture-keeping reparation |
| CN118161430A (en) * | 2024-02-22 | 2024-06-11 | 广州今盛美精细化工有限公司 | Skin care composition and preparation method and application thereof |
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Application publication date: 20180629 |